Unbiased Estimator for Deconvolving Human Blood into Antibody Composition
Motivation: We have a HIV antibodies, each with di↵erent neutralization profiles against v HIV-1 pseudo-viruses (measured in IC50). Given human blood, tested against the same viruses, we want to know the composition of antibodies, ✓. Caveat: Testing human blood against the panel of viruses gives measurements in ID50 not IC50. IC50’s do not add linearly. Solution: Transform the data. The Gibbs free energy,