The Relationship Between Knowledge of Stress Theory and Management Of

Total Page:16

File Type:pdf, Size:1020Kb

The Relationship Between Knowledge of Stress Theory and Management Of University of Massachusetts Amherst ScholarWorks@UMass Amherst Doctoral Dissertations 1896 - February 2014 1-1-1982 The relationship between knowledge of stress theory and management of stress as reflected in sources and symptoms of stress and in academic performance in associate degree nursing students. Marita Callahan University of Massachusetts Amherst Follow this and additional works at: https://scholarworks.umass.edu/dissertations_1 Recommended Citation Callahan, Marita, "The relationship between knowledge of stress theory and management of stress as reflected in sources and symptoms of stress and in academic performance in associate degree nursing students." (1982). Doctoral Dissertations 1896 - February 2014. 3793. https://scholarworks.umass.edu/dissertations_1/3793 This Open Access Dissertation is brought to you for free and open access by ScholarWorks@UMass Amherst. It has been accepted for inclusion in Doctoral Dissertations 1896 - February 2014 by an authorized administrator of ScholarWorks@UMass Amherst. For more information, please contact [email protected]. THE RELATIONSHIP BETWEEN KNOWLEDGE OF STRESS THEORY AND MANAGEMENT OF STRESS AS REFLECTED IN SOURCES AND SYMPTOMS OF STRESS AND IN ACADEMIC PERFORMANCE IN ASSOCIATE DEGREE NURSING STUDENTS A Dissertation Presented By SR. MARITA CALLAHAN, S.P. Submitted to the Graduate School of the University of Massachusetts in partial fulfillment of the requirements for the degree of DOCTOR OF EDUCATION May 1982 Education © Sr. Marita Callahan, S.P. All Rights Reserved 1982 11 THE RELATIONSHIP BETWEEN KNOWLEDGE OF STRESS THEORY AND MANAGEMENT OF STRESS AS REFLECTED IN SOURCES AND SYMPTOMS OF STRESS AND IN ACADEMIC PERFORMANCE IN ASSOCIATE DEGREE NURSING STUDENTS A Dissertation Presented By SR. MARITA CALLAHAN, S.P. Approved as to style and content by: Dr. Charlotte Rahaim, Member iii DEDICATION In loving memory of my parents JOHN J. AND MARY NALLY CALLAHAN and to the hopes and dreams of MARITA JEANNE CALLAHAN and her parents MICHAEL F. AND THERESE KELLY CALLAHAN ACKNOWLEDGEMENTS I wish to express my sincere gratitude to Dr. Grace J . Craig for the clarity and depth of her invaluable guidance and superb assistance directing this dissertation. Special thanks are due to Dr. Mary Kay Cressy for her keen interest, perceptive, prompt considerations and especially for remaining on my Committee after moving out of this area. Many thanks are due to Dr. Charlotte Rahaim for sharing her dynamic approach and perspective on the developing of this study and for her vision in developing and implementing this off-campus Community College graduate program. I especially want to thank Pauline Ashby for her very kind, thoughtful assistance. I am indebted to each nursing student who has enrolled in the Nursing Program at Holyoke Community College. In particular, very special thanks are due to the Class of 1982 for their crucial contributions to this study. Throughout the development of this study, continual thanks are overdue to Janet Vadnais Courtney for her generous, ongoing dialogue, insight and validations. I also wish to express appreciation to Dale Cadran for his encouragement, direction and invaluable help and to Dean Phillip Campbell for his most kind interest, assistance and consideration. v Many thanks are due to Sister Mary Catherine Laboure, S.P. and each Sister of Providence, especially Sister Mary Horgan, S.P. for her sensitivity and understanding, and Sister Marie Thaddeus, S.P. for her sustained help and continued interest. I also want to express my gratitude to Sister Mary Doloretta, S.P. and the Sisters at Bethlehem Convent for many kindnesses and for living through this study with me. Very special appreciation is due to Frank and Teresa Callahan; Jack, Mary Lee, Katie and Meghan Callahan; 1982 and Maura Marge, Bob, Marykate—Class of — , Michelle Ducharme for their sustained interest and encouragement and for monitoring the process of this dissertation. vi . ABSTRACT The Relationship Between Knowledge of Stress Theorv and Management of Stress As Reflected in Sources and Symptoms of Stress and in Academic Performance in Associate Degree Nursing Students (May 1982) Sister Marita Elizabeth Callahan, S.P., B.S. Boston College; MSN, The Catholic uni- versity of America, MS (R) , St. Louis University; Ed.D., University of Massachusetts/Amherst Directed by: Professor Grace J. Craig This study was designed to investigate the relation- ship between knowledge of stress theory and management of stress as reflected in reported sources and symptoms of stress and in academic performance of associate degree nursing students The sample of this study was 41 nursing students currently enrolled in a Nursing Program in a community college in New England. A pretest posttest training design was used. One group received a videotaped module about knowledge of stress, based on Selye's and Lazarus' theories augmented with counseling interviews. The other group did not. Management of stress was measured by 1) sources and measure symptoms of stress and 2) academic performance. The ments used in this study were the Stress Audit, the Life vi i Stress Questionnaire, a teacher made test on Knowledge of Stress and Quality Point Averages. Findings revealed there were significantly fewer symptoms of stress for the experimental group than for the control group (p <-. 05 ). Further students in the experimental group reported significantly less internal pressures whereas students in the control group reported significantly greater pressures. Significant correlations between knowledge of stress theory and management of stress as reflected in academic performance were absent. In conclusion, there was evidence to support the prediction that nursing students can be helped to cope more effectively with stress by this mode of instruction. viii TABLE OF CONTENTS ACKNOWLEDGEMENTS iv ABSTRACT vi LIST OF TABLES xii Chapter I. INTRODUCTION 1 4 The Concept of Stress • . 8 Problem Statement- - - - Sub-Problems 9 Hypothesis 9 10 Definition of Terms • Limitations of the Study 12 II. REVIEW OF THE LITERATURE- - 14 14 Overview of the Theory of Hans Selye - • Historical Development 14 Theory Development 17 Overview of the Theory of Richard S. Lazarus 21 Theory Development 22 Application of Stress Theory to Nursing Education 25 Stress and Clinical Practices in Nursing Students and Graduate Nurses 26 Responses of Nursing Students to the Clinical Area 26 Responses of Nursing Students to Role Change to Graduate Nurses 29 Responses of Patients and Nurses to the Stressful Environment 31 Reaponses of Intensive Care Nurses to the Stressful Environment 32 Stress and Educational Preparation Nursing Students and for 35 Graduate Nurses and Associate Degree Stress 35 for Nursing Students* Education 37 Stress Education for Nurses- • • • IX Issues in the Measurement of Psychological Stress 40 The Structured Questionnaire/ Checklist 40 The Unstructured Audit 4 4 The Interview 4 5 The Questionnaire/Interview • . 45 Conclusion 4 7 1 1 1 - METHODOLOGY 4 9 Design 50 Hypotheses Description of Sample 52 Instruments 53 The Stress Audit 5 3 The Life Stress Questionnaire 54 Knowledge of Stress 56 Training Module 57 59 Measurements of Academic Performance- - - The Comparative Guidance and Placement Program (C.G.P.) 50 Pilot Study 61 Data Analysis 67 Protection of Human Rights 67 IV. RESULTS 6 9 Comparability of Samples: Demographic Factors and Academic Ability 69 Stress Levels—Pretest 76 Training Module on Stress Theory and Management 82 Comparability of Samples Stress Levels— Posttest 83 Academic Levels — Posttest 90 • • V. DISCUSSION , SUMMARY AND RECOMMENDATIONS 97 Stress Knowledge and Stress Symptoms Results 98 Stress and Academic Performance Results -102 Interview Results 106 Limitations HI Implications for Nursing Education- • • 112 Recommendations 115 x REFERENCES 116 APPENDICES 125 Appendix A Stress Audit (SA) 126 Appendix B Life Stress Questionnaire (LSQ) . 128 Appendix C Knowledge of Stress Test (KS) . .131 Appendix D Stress Module Learning Guide . .135 Appendix E Permission for Participating in Study 139 xi LIST OF TABLES Table 1. Comparison of Stresses and Satis- factions on the Stress Audit (SA) as Reported in Rank Order by the Nursing Group and the Business Group of Students in the Pilot Study 6 3 2. Comparison of the Means of Numbers of Symptoms on the Pretest and Posttest of the Life Stress Questionnaire (LSQ) as Reported by the Nursing Group and the Business Group of Students in the Pilot Study 64 3. Comparison of Pretest and Posttest Percentage of Number and Symptoms on the Life Stress Questionnaire (LSQ) that Increased, Decreased or Remained the Same as Reported by the Nursing Group and the Business Group of Students in the Pilot Study 6 5 4. Age, Sex and Marital Status of Nursing Students in the Experimental, Control and Baseline Groups 7 0 5. Means, Standard Deviations and t-Values of the Comparative Guidance and Place- ment (CGP) Subtest Upon Admission to the Nursing Program for the Experimental and Control Groups 6. Means, Standard Deviations and t-Values of the Comparative Guidance and Placement (CGP) Subtests Upon Admission to the Nursing Program for the Combined Experi- mental and Control Groups (Class of 1982) and the Baseline Group (Class of 1981) • • 7. Means, Standard Deviations and t-values of the Cumulative Quality Point Averages (QPA) at the Beginning of the Second Semester, First Year for the Experimental and Control Groups xii 8 . Means, Standard Deviations and t-Values of the Cumulative Quality Point
Recommended publications
  • The Nature of Stress Nature The
    © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION 1 PART ONE © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones &The Bartlett Learning, Nature LLC © Jones of & Bartlett Stress Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION Believe that life is worth living and Used with permission. © Inspiration Unlimited. © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC yourNOT belief FOR SALE will OR DISTRIBUTIONhelp create the fact.NOT FOR SALE OR DISTRIBUTION —William James © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning LLC, an Ascend Learning Company. NOT FOR SALE OR DISTRIBUTION. © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC
    [Show full text]
  • Selye H. the General Adaptation Syndrome and the Diseases of Adaptation
    Number 13 March 28, 1977 Citation Classics Selye H. The general adaptation syndrome and the diseases of adaptation. Journal of Clinical Endocrinology 6:117-231, 1946. The general adaptation syndrome is defined of stress in its entirety and, although much has as the sum of all non-specific, systemic been learned since then, every word in the reactions of the body which ensue upon paper still applies today. long continued exposure to stress. The "I wrote The Stress of Life in the belief that paper calls attention to the possible connec- because the general public was becoming tion between the adaptation syndrome and keenly aware of the role played by stress in their various diseases. If this linkage can be own lives, they would like to understand just proven, the author contends, then it follows what stress is and what it does to us. At the end that some of the most common fatal of that volume I inserted a few philosophical diseases of man are due to a breakdown of musings on a code of behavior designed to the hormonal adaptation mechanism. [The meet and constructively deal with the stress of SCI® indicates that this paper was cited 167 life... times in the period 1961-1975.] "I went on to write another volume. Stress Without Distress,2 in which I expanded what I had called a 'philosophy of gratitude' into a Hans Selye, C.C., M.D., Ph.D., D. Sc. code of behavior named 'altruistic egoism' and Universite de Montreal based on the conviction that by earning our Institut de Medecine neighbor's love and becoming necessary to Case Postale 6128 him, we can satisfy our own selfish needs while Montreal 101, Canada helping others.
    [Show full text]
  • Faits Saillants De La Recherche En Gastroentérologie Par Les Canadiens Milestones of Research in Gastroenterology by Canadians
    Milestones of Research in Gastroenterology by Canadians Ivan T Beck. Queen’s University. Kingston. ON. Awardees of CAG Awardees of CAG Gastric Physiology Hormones Stem cells, Iron, Motility Hepatology Ivan T Beck Lecturers Richard McKenna lecturers Alexis St.Martin William Beamont Frederick G Banting and Charles H Best Charles Phillippe Leblond Aron M Rappaport 1904 - 1992 see poster 1794-1881 1785-1853 1891-1941 1899 -1978 1910 - Dr. Carl A Goresky (by Dr.J.J.Connon ) 1996 “Captions of History of CAG” Research subject Treating a gun Dr. Claude C Roy 1997 Extract insulin in 1921 from Dr Leblond obtained his MD at the Université de Paris (1934) Born in Bukowina ( a duchy of the Austrio-Hungarian whose gastric shot wound, Dr. Joseph J Connon 1998 DSc at Sorbonne(1945) and PhD at McGill( 1946) monarchy). MD 1929 Prague. Surgical training Berlin fistula allowed Dr. W. Beamont dog pancreas and Paris. During World War II, surgeon in Bucharest, Dr. Eldon A Shaffer 1999 for the study of created a gastric Banting, a practicing surgeon theorized Dr. Noel C Williams 2000 fistula. In 1946 he initiated the method of radioautography,which Rumania. Came to Canada and joined Dr. C.H Best as gastric secretory that ligating the pancreatic duct, the Dr. Grant W Thompson 2001 function. He carried out enabled him to trace the activity of movement of substances Assistant in the Department of Physiology in 1946. Ph.D. exocrine function will atrophy and in vivo. Using this method he established that cells are 1952. Professor, Physiology, University of Toronto 1962 Dr.
    [Show full text]
  • STRESS and the GENERAL ADAPTATION SYNDROME* by HANS SELYE, M.D., Ph.D., D.Sc., F.R.S.C
    BRITISH MEDICAL JOURNAL LONDON SATURDAY JUNE 17 1950 I STRESS AND THE GENERAL ADAPTATION SYNDROME* BY HANS SELYE, M.D., Ph.D., D.Sc., F.R.S.C. Professor and Director of the Institute of Experimental Medicine and Surgery, Universite de Montreal, Montreal, Canada With the concept of the general adaptation syndrome we factorily elucidated. In fact, we shall never truly " under- have attempted to integrate a number of seemingly quite stand" this phenomenon, since the complete comprehen- unrelated observations into a single unified biologic system. sion of life is beyond the limits of the human mind. But I would draw attention briefly to the work of Claude there are many degrees of " elucidation." It seems that the Bernard, who showed how important it is to maintain the fog has now been just sufficiently dispersed to perceive the constancy of the "milieu interieur" ; Cannon's concept of general adaptation syndrome through that measure of " homoeostasis "; Frank Hartmann's " general tissue hor- "twilight " which permits us to discern the grandeur of mone" theory of the corticoids; Dustin's observations on its outlines but fills us with the insatiable desire to see the " caryoclastic poisons," the " post-operative disease," more. the curative action of fever, foreign proteins, and of other We realize that many lines in our sketch will have to be " non-specific therapeutic agents "; the " nephrotoxic sera " hesitant, some even incorrect, if we try to put on paper of Masugi; and to the " Goldblatt clamp" for the now what we still see only vaguely. But a preliminary production of experimental renal hypertension.
    [Show full text]
  • Half a Century of Stress Research: a Tribute to Hans Selye by His Students and Associates*
    EXPERIENTIA Volume 41/No. 5 Pages 55%700 15 May 1985 Reviews Half a century of stress research: a tribute to Hans Selye by his students and associates* Hans Selye died in 1982 in Montreal, Canada, at the age of 75. A native of Austria and Hungary, he did a fellowship at Johns Hopkins University, then went to McGill University for more than a decade of research and subsequently he founded the Institute of Experimental Medicine and Surgery at the University of Montreal in 1945. He remained at the Institute until his forced retirement one year prior to his death. Towards the end of his career he established the International Institute of Stress where he was active virtually until the last few weeks of his life. By his own account, his ideas and early experiments substantially preceded the historical short report on 'A syndrome produced by diverse nocuous agents' published in the 4 July 1936 issue of'Nature'. Hence, it is appropriate to label his efforts as a half a century quest for the characterization and elucidation of biologic stress. On the first anniversary of Dr Selye's death his former students and coworkers gathered in Montreal to commemorate the scientific achievements that can be associated with Dr Selye's institute. The program of this two-day Symposium Hans Selye consisted of historical interludes and brief reviews on ongoing research by those who are still active in investigative work. Two special lectures were presented by Dr Julius Axelrod of the National Institutes of Health and Dr Judah Folkman of Harvard Medical School.
    [Show full text]
  • Physiology News
    PN Issue 107 / Summer 2017 Physiology News Open science movement The war to liberate knowledge Future Physiology 13 - 14 December 2017 Leeds, UK A two-day scientific and career development conference organised by early career physiologists. www.physoc.org/futurephysiology Physiology News Editor Roger Thomas We welcome feedback on our membership magazine, or letters and suggestions for (University of Cambridge) articles for publication, including book reviews, from our Members. Editorial Board Please email [email protected] Karen Doyle (NUI Galway) Physiology News is one of the benefits of membership, along with reduced registration rates Rachel McCormick for our high-profile events, free online access to our leading journals,The Journal of Physiology, (University of Liverpool) Experimental Physiology and Physiological Reports, and travel grants to attend scientific Graham Dockray meetings. Membership offers you access to the largest network of physiologists in Europe. (University of Liverpool) Keith Siew Join now to support your career in physiology: (University of Cambridge) Visit www.physoc.org/membership or call 0207 269 5721 Austin Elliott (University of Manchester) Mark Dallas (University of Reading) Membership Fees for 2017 FEES Fiona Hatch Fellow £120 (Cello Health Communications iScience, Medical writer) Member £90 Managing Editor Retired Member – Julia Turan YOUTUBE LOGO SPECS Affiliate £40 [email protected] PRINT on light backgrounds on dark backgrounds Associate £30 standard standard main red gradient bottom PMS 1795C PMS 1815C www.physoc.org C0 M96 Y90 K2 C13 M96 Y81 K54 Undergraduate – white black WHITE BLACK no gradients no gradients C100 M100 Y100 K100 @ThePhySoc C0 M0 Y0 K0 Opinions expressed in articles and letters submitted by, or commissioned from, Members, Affiliates or outside bodies /physoc are not necessarily those of The Physiological Society.
    [Show full text]
  • Introduction to Psychoneuroimmunology.Pdf
    INTRODUCTION TO PSYCHONEUROIMMUNOLOGY ThisPageIntentionallyLeftBlank. INTRODUCTION TO PSYCHONEUROIMMUNOLOGY Jorge H. Daruna Department of Psychiatry and Neurology Tulane University School of Medicine AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Elsevier Academic Press 200 Wheeler Road, 6th Floor, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, California 92101-4495, USA 84 Theobald’s Road, London WC1X 8RR, UK This book is printed on acid-free paper. Copyright ß 2004, Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone: (þ44) 1865 843830, fax: (þ44) 1865 853333, e-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting ‘‘Customer Support’’ and then ‘‘Obtaining Permissions.’’ Library of Congress Cataloging-in-Publication Data Application submitted. British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library. ISBN: 0-12-203456-2 For all information on all Academic Press publications visit our Web site at www.books.elsevier.com Printed in the United States of America 04 05 06 07 08 09 9 8 7 6 5 4 3 2 1 For Brandon and Caroline ThisPageIntentionallyLeftBlank. PREFACE This book presents an introduction to psychoneuroimmunology, which is the scientiWc discipline best poised to elucidate the complex processes that underlie health.
    [Show full text]
  • Chapter 5. Diverse Understandings of Stress
    distribute or DIVERSE post, UNDERSTANDINGS OF STRESS copy, CHAPTER 5 not Do Copyright ©2019 by SAGE Publications, Inc. This work may not be reproduced or distributed in any form or by any means without express written permission of the publisher. iStockphoto.com/ imtmphoto Chapter 5 Outline Measuring Up: Got Daily Hassles? What's Your Culture as a Critical Stressor Stress Score? Perceived Discrimination Ponder This Stress, Hormones, and Genes What Is Stress? Different Varieties of Stressors Measuring Stress Relationship Stress Stress over Time Work Stress Main Theories of Stress Environmental Stress Cannon’s Fight-or-Flight Theory Consequences of Stress Taylor et al.’s Tend-and-Befriend Post-Traumatic Stress Disorder Theory APPLICATION SHOWCASE: Stress Really Selye’s General Adaptation Can Kill: The Baskerville Effect, Culture, and Syndrome Stress Lazarus’s Cognitive Appraisal Model SUMMARY Factors Influencing Our Appraisals TEST YOURSELF KEY TERMS, CONCEPTS, AND PEOPLE The Role of Culture in Appraisal ESSENTIAL READINGS Stress and Psychopathology: The Diathesis- Stress Model distribute MEASURING UP or GOT DAILY HASSLES? WHAT'S YOUR STRESS SCORE? dentify which of the following 17. Increased workload at school 37 events you experienced in the past Isix months. post,18. Outstanding personal achievement 36 19. First semester in college 35 1. Death of a close family member 100 20. Change in living conditions 31 2. Death of a close friend 73 21. Serious argument with instructor 30 3. Divorce between parents 65 22. Lower grades than expected 29 4. Jail term 63 23. Change in sleeping habits 29 5. Major personal injury 63 24. Change in social habits 29 6.
    [Show full text]
  • Hans Selye and His Studies on the Role of Mast Cells in Calciphylaxis and Calcergy
    Inflammation Research (2019) 68:177–180 https://doi.org/10.1007/s00011-018-1199-7 Inflammation Research HISTORY OF INFLAMMATION Hans Selye and his studies on the role of mast cells in calciphylaxis and calcergy Domenico Ribatti1 Received: 7 November 2018 / Accepted: 12 November 2018 / Published online: 19 November 2018 © Springer Nature Switzerland AG 2018 Abstract Hans Selye was an endocrinologist, a pioneer of research on biological stress in human individuals and groups. His most important scientific contributions include in 1936 the evidence that the pituitary–adrenal–thymus axis was activated by vari- ous nocuous stimuli, which led to the involution of the thymus and of the lymphoid organs; in 1946, the theory of general adaptation syndrome (GAS), pointing out that this is a general reaction that leads to resistance of the organism to various insults. This review article is focused on the general interest of Selye on the important role played by mast cells in different pathological conditions and in particular in calciphylaxis and calcergy, summarized in a classic book, which is a lasting contribution on the subject. Keywords Calciphylaxis · Calcergy · General adaptation syndrome · History of medicine · Mast cells · Stress Biographic sketch until his death, on October, 16, 1982. Dr. Selye is survived by his wife, Louise (Fig. 2), and five children: Catherine, Hans Selye (Selye János in Hungarian), was born in Michel, Jean, Marie and Andre. Komarno, Slovakia (at that time Komárom, Hungary) on Dr. Selye wrote more than 1700 scholarly papers and 39 January 27, 1907. Selye attended school at a Benedictine books on the subject. At the time of his death on October monastery, and since his family had produced four genera- 16,1982, his work had been cited in more than 362,000 sci- tions of physicians, entered the German Medical School in entific papers, and in countless popular magazine stories, in Prague at the age of 17.
    [Show full text]
  • Adaptive Homeostasis 4 5 Q1 Kelvin J.A
    ARTICLE IN PRESS Molecular Aspects of Medicine ■■ (2016) ■■–■■ Contents lists available at ScienceDirect Molecular Aspects of Medicine journal homepage: www.elsevier.com/locate/mam 1 Q2 Review 2 3 Adaptive homeostasis 4 5 Q1 Kelvin J.A. Davies a,b,* 6 a Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, The University of Southern California, Los Angeles, CA 7 Q5 90089-0191, USA 8 b Division of Molecular and Computational Biology, Department of Biological Sciences, Dornsife College of Letters, Arts, & Sciences, The Uni- 9 versity of Southern California, Los Angeles, CA 90089-0191, USA 10 11 12 ARTICLE INFO ABSTRACT 13 1514 Article history: Homeostasis is a central pillar of modern Physiology. The term homeostasis was invented 1716 Received 15 April 2016 by Walter Bradford Cannon in an attempt to extend and codify the principle of ‘milieu 1918 Accepted 15 April 2016 intérieur,’ or a constant interior bodily environment, that had previously been postulated 20 Available online 21 by Claude Bernard. Clearly, ‘milieu intérieur’ and homeostasis have served us well for over 2322 a century. Nevertheless, research on signal transduction systems that regulate gene ex- 2524 Keywords: pression, or that cause biochemical alterations to existing enzymes, in response to external 26 Homeostasis 27 and internal stimuli, makes it clear that biological systems are continuously making short- 28 Adaptation 3029 Stress term adaptations both to set-points, and to the range of ‘normal’ capacity. These transient 3231 Hormesis adaptations typically occur in response to relatively mild changes in conditions, to pro- 3433 Nrf2 grams of exercise training, or to sub-toxic, non-damaging levels of chemical agents; thus, 3635 Aging the terms hormesis, heterostasis, and allostasis are not accurate descriptors.
    [Show full text]
  • The Legacy of Hans Selye and the Origins of Stress Research: a Retrospective 75 Years After His Landmark Brief “Letter” to the Editor# of Nature
    Stress, September 2012; 15(5): 472–478 q Informa Healthcare USA, Inc. ISSN 1025-3890 print/ISSN 1607-8888 online DOI: 10.3109/10253890.2012.710919 The legacy of Hans Selye and the origins of stress research: A retrospective 75 years after his landmark brief “Letter” to the Editor# of Nature SANDOR SZABO1,*, YVETTE TACHE2, & ARPAD SOMOGYI3,* 1VA Long Beach Healthcare System and Departments of Pathology and Pharmacology, University of California-Irvine, Long Beach, CA, USA, 2Digestive Diseases Division, Department of Medicine, CURE Digestive Diseases Research Center, Oppenheimer Family Center for Center for Neurobiology of Stress, University of California-Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA, and 3EU Select, Inc., Brussels, Belgium (Received 30 January 2012; revised 6 July 2012; accepted 7 July 2012) Abstract Hans Selye’s single author short letter to Nature (1936, 138(3479):32) inspired a huge and still growing wave of medical research. His experiments with rats led to recognition of the “general adaptation syndrome”, later renamed by Selye “stress response”: the triad of enlarged adrenal glands, lymph node and thymic atrophy, and gastric erosions/ulcers. Because of the major role of glucocorticoids (named by Selye), he performed extensive structure–activity studies in the 1930s–1940s, resulting in the first rational classification of steroid hormones, e.g. corticoids, testoids/androgens, and folliculoids/estrogens. During those years, he recognized the respective anti- and pro-inflammatory actions of gluco- and mineralocorticoids in animal models, several years before demonstration of anti-rheumatic actions of cortisone and adrenocorticotrophic hormones For personal use only.
    [Show full text]
  • General Adaptation Syndrome (GAS)
    Definition of stress and GAS GAS is a term describing body's short-and long-term reactions General adaptation and adaptations to stress in order to restore homeostasis, which, regardless on the nature of the stress, have quite syndrome (GAS) uniform pattern stress – a sum of biological reactions to stimul or events that we perceive as Definition of stress and GAS challenging or threatening (= stressors) that tends to disturb the homeostasis “positive” stress (eustress) – limited duration, helps to overcome daily Phases of stress reaction challenges and accomplish demanding tasks → stimulates performance and leads to reward afterwards ( lack of ability to react to stress due to Consequences of GAS diseases affecting the relevant pathways (e.g. Addison disease) is life-threatening “negative” stress (disstress) - should the compensating reactions be inadequate or inappropriate or stressor acts far too long, they may lead to disorders stressor – any factor disturbing body homeostasis type: physical, mental, emotional source: external or internal 1 2 GAS was introduced by Hans Selye Stages of stress & their purpose Austrian-born physician (1907-1982) who emigrated to Canada (1) alarm reaction (AR) in 1939 –fright → fight or flight (F&F or Cannon´s emergent reaction) – born in Hungary, studied in Prague – the body's resistance to physical damage drops for a short-time so that organism can – he searched for a new hormone (by injecting rats with ovary extracts, which produced enlargement of adrenal cortex, involution of immune rearrange
    [Show full text]