EUROPEAN SOCIETY OF NEWSLETTER

Summer 2020

Editor: Prof. Gordan Vujanić Associate editor: Prof. Metka Volavšek Layout: Dr Christos Poulios

Table of Contents MESSAGE FROM THE PRESIDENT OF THE ESP ...... 2 (By Prof. Holger Moch) ...... EDITOR’S MESSAGE ...... 3 (By Prof. Gordan Vujanić) ...... THE ESP MONTHLY WEBINAR: A VIRTUAL GATHERING NOT TO BE MISSED ...... 4 (By Prof. Aurelio Ariza, ESP Secretary) .... MEMORIAL TRIBUTE: PROFESSOR (1940-2020) ...... 6 (By Prof. Manuel Sobrinho Simões) ...... JUAN ROSAI: THE HERITAGE ...... 8 (By Professors Gianni Bussolati and Vincenzo Eusebi) ...... SOME RECENTLY PUBLISHED BOOKS . 9 (By Prof. Metka Volavšek) ...... GLASGOW 2020 ...... 15

Summer 2020

Message from the President of completely new virtual and interactive educa- tion environment for the ESP-IAP Congress the ESP 2020 within the next weeks. The exact format (By Prof. Holger Moch) of the virtual ESP-IAP Congress 2020 is cur- rently being confirmed, but we realise that

learning in the virtual environment is different Dear ESP Mem- from live meetings. We will shorten the con- bers, Dear Col- gress to 3 days and have reduced the regis- leagues tration fees. In an effort to provide an interac- tive and engaging meeting, we will retain the Over the last basic programme previously agreed, but we months, we have will modify it to reflect experiences gained spent time con- from using virtual delivery platforms in other necting to each recent virtual meetings and in our 2 COVID- other in a way very 19 webinars. We want to create opportunities uncommon to our to interact virtually with colleagues in network- conventional gathering ing for and with industry through dedicated using a smart technology to maintain some symposia. There will be interactive moder- semblance of normality. The current crisis is ated Q&A sessions and keynote lectures and obviously not yet over but we are learning we plan a dedicated Covid-19 pathology ses- how to cope with it efficiently. We are truly sion. We understand that this is a change thankful to our members for their tenacity and from the normal operations, but we hope that aspiration to support and engage with the vir- you will still participate in the virtual meeting tual activities provided or/and planned by the which should be both interesting and engag- ESP. ing.

I recently had to communicate to you that the I hope to have you with us for the virtual con- joint XXXIII Congress of the International ference in December. Please visit the ESP Academy of Pathology and 32nd Con- and Congress websites (www.esp-con- gress of the European Society of Pathol- gress.org; www.esp-pathology.org) for up- ogy scheduled for Glasgow will be deliv- dates and FAQs. ered as a virtual event (6th-8th December 2020). This was a result of the non-availability Other activities of the Scottish Event Campus. The current COVID-19 situation demonstrates that this The ESP/UEMS Pathology Progress Test decision will ensure the safety of ESP’s fac- was successfully carried out online between ulty and attendees. However, a huge amount 8th – 19th June. A total of 900 participants (66 of work was already done and the programme Countries) entered the test and all were in- for the congress was almost completed. I vited to leave their feedbacks at the end of the have to thank all people involved in working test. We are delighted to announce that on the programme and have to encourage the ESP/UEMS will organise the second edition Executive and Education Committees of ESP of this progress test in November this year so and the British Division of the IAP to set-up a

Summer 2020

please visit the ESP website regularly for the We firmly believe we are delivering what is re- exact date of the test. quired in this time but, as ever, we remain open to your suggestions so please continue Following our successful webinars on to share your thoughts, ideas and feedback COVID-19 in May and June, a new series of with us. ESP webinars will be organised by the ESP Working Groups between September 2020 For now, we continue to stand together while and March 2021, which will address an array we are far apart. of hot topics in particular pathology subspe- cialties. ESP members will be invited to at- All the best, tend and actively participate in these virtual activities at no cost. More information on this Holger Moch, MD will be available soon on the ESP website. President of the European Society of Pathol- ogy In addition, ESP has been invited by USCAP to organise a virtual educational session at the USCAP 2021 Virtual Meeting (13-18 March). ESP will, as ever, be preparing an in- teractive and engaging scientific programme Editor’s Message which will be delivered by renowned ESP (By Prof. Gordan Vujanić) Speakers. We are experi- In our current ESP newsletter, you will also encing some- read an obituary for Juan Rosai, MD, written thing that we by Gianni Bussolati and Vincenzo Eusebi. have never ex- Juan Rosai was an outstanding member of perienced be- the European Society of Pathology. He fore… and passed away in , , on July 7, 2020, hopefully will not after a long illness. Although he worked for have to face any many years in the US, Rosai had a major im- time soon, alt- pact on pathologists in Europe, as you can hough this may read in the obituary. sound a bit over-opti- mistic considering unpredictability of this pan- With all ESP Committees and ESP HQ in demic. We had to re-adjust the ways we live, Brussels, we are putting all our efforts into work, and communicate, and to discover new supporting our members through these chal- ways of doing many things in our private and lenging times and will activate and make use professional lives. Some proved to be rela- of the latest technology and platforms to de- tively easy to adapt to, like online meetings liver information, facilitate knowledge-sharing and seminars, but it will be interesting and and allow the continued development of inter- challenging to organise and ‘attend’ big national collaborations and partnership. events like our joint Congress in December. We all hope and believe it will be successful,

Summer 2020

although a very important point of these meet- and, possibly, a highly lethal second wave in ings – a personal contact with colleagues and the autumn. friends - will be impossible to replace with an- ything. Today, however, easy access to the Internet and peace amongst the major powers are a But, as always, life goes on, and we are doing far cry from the shaky telegraph and tele- our best to maintain our professional activities phone communications and suicidal Great within the ESP and wider. You will read about War humankind had to deal with in 1918. these in the President’s and the Secretary’s Now, a few mouse clicks are all required to be messages. transported to a virtual gathering on a screen where knowledge and opinions can be safely A really sad piece of news for all pathologists shared while keeping physically distant. Such worldwide is about the death of one of the gi- has been the case with the two webinars on ants of pathology – Juan Rosai, a truly re- Covid-19 recently held by the ESP for its markable person, pathologist and teacher. membership across Europe. The webinars, sponsored by AstraZeneca Spain and first And finally, you will find a good selection and proposed by the Spanish Society of Pathol- review of recently published books prepared ogy, took place on May 8th and June 25th. by our Associate Editor Prof. Metka Volavšek, but, noticeably, there is no list of forthcoming The broad-perspective first webinar (“Covid- meetings… 19: Unprecedented daily challenges in pathol- ogy departments across Europe”) discussed the various countries’ responses to the many The ESP Monthly Webinar: A organisational issues and biosafety concerns virtual gathering not to be posed by Covid-19, including reorganisation missed of departments (Prof Xavier Matias-Guiu), management of samples (Prof Mattia Bar- (By Prof. Aurelio Ariza, ESP Secretary) bareschi), handling of corpses (Prof Gustavo Baretton) and impact on molecular testing Many analogies (Prof Paul Hofman). Appropriately, the speak- are being drawn ers were representatives of the pathology na- these days be- tional societies of Spain, Italy, Germany and tween Covid-19 France, countries where the Covid-19 and the Great In- scourge has been felt with particular severity. fluenza pan- Profs Holger Moch, Marco Santucci and Xa- demic of 1918 vier Matias-Guiu moderated the event. (so-called “Span- ish Flu” because In contrast, the second webinar (“Methods for the uncensored SARS-CoV-2 detection in tissues and Covid- press of non-belligerent 19 pulmonary and cardiovascular Pathology“) Spain broke the terrible news to a world at focused more specifically on just two topics war). Common features of these two pandem- related to Covid-19. The subjects discussed ics include an overly dramatic cytokine storm

Summer 2020

were coronavirus detection techniques in pa- made the recorded material accessible to all thology samples (Prof Zsuzsanna Varga) and members through the ESP channel on the gross and microscopic findings shown by YouTube. Much appreciated assistance from the lung, heart and blood vessels (Profs Fio- a professional IT provider was also available. rella Calabrese and Cristina Basso). Profs Ales Ryska and Aurelio Ariza were the mod- Effective communication of scientific data and erators. their subsequent vivid discussion were deftly achieved in both webinars. Additionally, both After paying the current pandemic its due, experiences provided us all with great oppor- ESP webinars will deal with other issues of tunities to test and hone our virtual communi- current interest when, after the summer cation skills. For the most part things ran break, they resume in September with a smoothly on both occasions. Nevertheless, monthly periodicity. The experience gained there was still room for improvement, as ex- from the May and June events will certainly pected from the not uncommon lack of famili- help to improve upcoming webinar editions arity with platform operations and the great and ESP virtual activities as a whole, includ- variety of IT tools used by panelists and par- ing the entirely online European Congress of ticipants. Indeed, it is not a bad idea to have Pathology to be held in early December 2020. some hands-on technical help available In this regard, technical aspects are of para- nearby just in case something goes awry. mount importance. First of all, heavy work by the ESP HQ (Dr Raed Al-Dieri, Dr Christos Even more so than physical performances, Poulios and Ms. Sarah Byaruhanga) before, virtual presentations require careful attention during and after the webinars was essential to body language, now narrowly limited to a for a successful outcome on both occasions. detailed close-up of our facial expressions Prior actions included the coordination of and head and hand movements. Appearing moderators and speakers and the collection on screen too far or too near, too off-centred of questions sent beforehand by participants. or too skewed, too fidgety or too still, too dark During the events a major concern was the or too light may significantly detract from the establishment of stable Internet connections. quality of an otherwise excellent presentation. Fortunately, no significant connectivity issues Making sure we exert a proper control of our arose in spite of the fact that moderators and microphone is also crucial. Not to be ne- speakers hailed from a variety of countries glected either is the backdrop shown on with dissimilar IT features. screen, which will be scrutinized by viewers all through our time on camera. No doubt the Also, as the webinar developed, the ESP HQ quality of ESP webinars will progressively personnel coordinated the reception of ques- benefit from our gradual collective steeping in tions by participants through the platform the not-always-intuitive niceties of virtual Q&A section and facilitated those questions communication. to the moderators. During the overall discus- sion section, the moderators read the ques- A crucial part of each webinar is the overall tions to the audience and then the speakers discussion section, during which the speakers offered their replies and comments. Upon answer the questions sent by participants. completion of each of the two events, the HQ

Summer 2020

Sufficient time should be allocated by the or- filed them in a systematically well-organised ganisers to this most lively segment of the way. The same holds true for the large num- webinar, which is devoted to the active partic- ber of consultancy cases he got every week ipation of attendees and the fruitful interaction including clinical histories, slides and, when- amongst speakers and moderators. Conse- ever possible, follow-up data. Juan had one quently, it is advised that the number of of the most powerful and intelligent /opera- speakers be limited to two or three and their tional “memories” I have ever encountered. It presentations do not exceed twenty or thirty was the stuff of legend to witness him dictat- minutes each. ing to a recorder the final version of a paper or a chapter he had just finished – references In conclusion, stay tuned for the ESP monthly included! webinars coming back in September and, in the meantime, enjoy a healthy summer away from the crowd-loving, crown-wearing virus.

Memorial tribute: Professor Juan Rosai (1940-2020)

(By Prof. Manuel Sobrinho Simões) Fig, 1: San Miniato, Italy, 1984 – The meeting On July 7, 2020, Prof. Juan Rosai passed “of” the insular thyroid carcinoma away at the age of 79. I fondly remember the occasion we were with I met him almost forty years ago travelling be- Rudi Heimann in the Course of French tween the twin cities of Porto and Santiago de Division of IAP – member of the Faculty from Compostela. Besides being the best surgical 2007 to 2017 and Juan declaimed the full pathologist in the field of cancer diagnosis, I names of some 30 colleagues of his school in (we) think Juan Rosai was a first-class . He had emigrated from Italy to Ar- teacher and a unique human being. I had pre- gentina with his family when he was 8 and got viously heard about his characteristics. In his MD from at the age of 21. 1974, I got a handwritten card from Prof. Juan He started his in Hospital de Mar Rosai asking for a reprint of the paper we had del Plata under the supervision of D. Eduardo just published on the ultrastructure of the nu- Lescano and went on to Washington Univer- clei of papillary thyroid carcinomas (Letters sity in St. Louis recruited by his second pa- and reprints the Good Old Days…). Juan thology “maestro”, Dr was, then, starting his activities at Minnesota (Fig.1). University (1974) and I only realised later on that he obsessively followed the literature on numerous clinico-pathological entities and several subspecialties. He selected the jour- nals and reprints he was interested in and

Summer 2020

say that he liked to attend professional meet- ings in North America and loved to join more colourful initiatives in Latin America and me- ridional Europe. We embarked in several atypical meetings throughout South America and Latin European countries including two Pathology Congresses along the Pilgrim’s Way to Santiago de Compostela organised by Jeronimo Forteza (2004 and 2010) (Fig.3 and 4).

Fig. 2: Thyroid Cancer, WHO 2nd edition, Zurich, 1986 – Prof Hedinger acted as the “grand patron” and Juan Rosai as the rising star

Juan stayed in USA until 1999. After St. Louis and Minnesota, he was the chairman of pa- thology in Yale University (1985) and at the Memorial Sloan-Kettering Cancer Centre Fig 4: Arriving to Santiago de Compostela (II (1991) before moving to Instituto Nazionale Camiño de Santiago, Santiago, 2010) dei Tumori in Milan. All together Juan worked in USA for about 35 years and in Italy for Juan kept a friendly and very positive attitude about 20 years, including a sabbatical leave towards the ESP and attended several Euro- in Bologna and Firenze that produces several pean congresses (Fig.5). He was a mentor to seminal papers on thyroid pathology (Fig.2). countless fellows and trainees and actually enjoyed sitting down with residents discuss- ing cases whenever possible (Fig.6).

Fig 3: Award of Juan Rosai, “Porto City of Sci- ence”, Porto, 2010 Fig 5: Congress of the European Society of Juan travelled frequently, but never without a Pathology, Porto, 1989 – The Whatizzit Con- purpose. Oversimplifying the issue, one may text with our residents

Summer 2020

He loved history, soccer, opera and gastron- Juan Rosai: The heritage omy. Together with Maria Luisa and a couple of Italian colleagues you would travel to be (By Professors Gianni Bussolati and Vin- present in European and World Cup Finals. cenzo Eusebi) Juan was crazy about opera and besides the usual “places” (Alla Scala, Firenze, Paris- Confronted once with the critical question of Bastille,…) he even went to the surreal Ama- which factor was really pivotal in leading to zona Theatre in Manaus with our dearest excellence in diagnostic capacity, either the friend Marcello Franco. As for his interest in School, i.e. systematic education, or Memory, food I can never forgot how Juan and Bernard the bulk of sensible experience or Technology Caillou enjoyed a “Tête de Veau” in Brasserie and the practice of a methodological analysis, Lipp. Dr. Juan Rosai commented: “None of these: the critical factor is a knack, a gift of nature”. And he went on commenting: “in every Pa- thology lab, people recognize the gifted per- son who is able to solve difficult and unusual cases. He/she is not necessarily the oldest in the lab, nor the most experienced and the most prominent. Not even possibly the most intelligent or popular. But he or she can “see”, slides are not an inanimate conglomerate of cells and tissues: they speak and tell the hid- Fig 6: Discussing consultancy cases in den story of their origin and prospects”. Ipatimup, Porto, 2004 The process, in Dr. Rosai’s vision, was the re- Juan loved discussing history in general and sult of a dedicated, gifted and passionate pathology in particular. His knowledge was mind. Tissue structure was, in Dr. Rosai’s encyclopaedic as best illustrated by the su- eyes, revealing subtle details, from which he perb book “Guiding the Surgeon’s Hand” on was the only one able to get the correct diag- the history of nosis

Although Juan was compulsively concerned To fully delineate His character, His profes- with the relevance of cancer diagnosis for pa- sional activities, the quality of lectures and di- tients, he was always willing to help and agnoses, the relevance of His vast number of teach, and to build personal relations regard- scientific papers (well over 400), Editorial less of rank. commitments, the vast number of histological consultations (well over 60000 cases), of Prof. Juan Rosai was a giant amongst slide seminars (over 1400), and books, not pathologists. He is sorely missed. only of pathology, would need professional bi- ographers. Among the numerous books, he Manuel Sobrinho Simões wrote several editions of Rosai and Acker- man’s Surgical Pathology which all were and

Summer 2020

are useful to give the polar co-ordinates to Pathology in Bologna, Italy. correctly diagnose worldwide an infinite num- ber of lesions. He had very few frustrations. The greatest one was probably the fact that he had never Originally, he received an imprinting in diag- met Dr. J.G. Azzopardi from London after nostic Pathology in Buenos Aires and Rio de having read during a night flight the Az- la Plata (Argentina), under the wise and ded- zopardi’s book, “Problems in breast pathol- icated guide of Dr. Eduardo Lascano, whom ogy”. he always prized as his mentor. His profes- sional life had however a critical switch when They met in Bologna (Italy) in a restaurant he met Dr. Lauren V. Ackerman, who per- and discussed until very late of problems in suaded him to move to Saint Louis. His ap- pathology to such extent that a pathologist proach to histopathological diagnosis turned who sat at the table with them, was intellectu- clinically oriented and he soon became a bril- ally so hyper stimulated that he remembered liant, subtle and convincing interpreter of only a very limited portion of the discussion. Ackerman’s school, linking structural micro- He had the feeling since then that extraterres- scopical features to clinical evolution and re- trials might exist. sponse to treatment. Probably it was then when he conceived the book “Guiding the sur- Gianni Bussolati and Vincenzo Eusebi geon’s (and oncologist’s) hand”, for the sake On behalf of the Italian Society of Pathology of the patient. and Cytology (SIAPEC)

From St Louis he moved to the in Minneapolis, then to Yale Uni- Some recently published books versity in New Haven and finally landed in (By Prof. Metka Volavšek) New York, at the Memorial Hospital. This would have been a final destination for most people but not for Dr. J. Rosai, who finally moved to the Istituto Nazionale Tumori in Mi- lan. Several colleagues did wonder about the reason of this move. Probably he wanted to go back to his Italy, were his parents had orig- inated. A probable further attraction was la Scala, the opera house in Milan very much loved by him. No doubt he had a knack, but the natural gift was complemented by vision, organization, intellectual honesty, a mon- strous memory and a superior technology. Among the several interests in technology he WHO Classification of Soft Tissue and was the one who organised a transcontinental Bone tumours. consults session of pathology via the internet WHO Classification of Tumours, 5th Edition, in 1997, between an immunohistochemical Volume 3 society in New York and the Department of

Summer 2020

WHO Classification of Tumours Editorial Series: ROSE in Diagnostic Interventional Board (Eds.) Pulmonology 5th ed, 606 pages,  130 €, IARC (2020) JIng Feng, Wen Ning, Dianhua Jiang, Jingyu Chen, Bo Wu (Eds.) Soft Tissue and Bone Tumours is the third 252 pages, 170 €, Springer (2020) volume in the 5th edition of the WHO series This book demonstrates the recent advances on the classification of human tumours. This in rapid on-site evaluation (ROSE) for differ- series (also known as the WHO Blue Books) ential diagnosis of interstitial lung disease is regarded as the gold standard for the diag- (ILD). Interstitial lung disease is a group of dif- nosis of tumours and comprises a unique syn- fuse parenchymal lung disorders affecting the thesis of histopathological diagnosis with dig- interstitium, a part of the lung's anatomic ital and molecular pathology. These authori- structure, causing inflammation, scarring, or tative and concise reference books provide excess fluid. ILDs include interstitial pneumo- indispensable international standards for an- nia, idiopathic pulmonary fibrosis, nonspecific yone involved in the care of patients with can- interstitial pneumonitis, cryptogenic organiz- cer or in cancer research, underpinning indi- ing pneumonia and sarcoidosis, which are as- vidual patient treatment as well as research sociated with various degrees of morbidity into all aspects of cancer causation, preven- and mortality rates. tion, therapy, and education. ROSE has proven its value in diagnosis with routine transbronchial lung biopsy (TBLB) Atlas of Dermatopathology procedures, especially in difficult clinical Synopsis and Atlas of Lever’s Histopathology cases. The first part of the book discusses the of the Skin principals of performing ROSE procedures, David Elder reviews the basic concepts and summarizes 4th ed, 584 pages,  165€, Wolters Kluwer the distribution and morphology of tracheal/ (2020) bronchial/ pulmonary cells. The second part Offering a highly visual, systematic approach covers specific interstitial disorders, including to diagnosing skin diseases, Atlas of Dermat- a number of difficult and rare cases, and fea- opathology: Synopsis and Atlas of Lever’s tures iCT images and cytological illustrations. Histopathology of the Skin, 4th Edition, is an Providing readers with valuable insights, the ideal reference tool or teaching aid for der- book is an important resource for practitioners matopathologists, pathologists, dermatolo- involved in the care and treatment of patients gists, and trainees. This unique atlas uses a with ILD. pattern-based approach to differential diagno- sis, clearly organised according to what is Oncological Surgical Pathology seen on a microscopic slide. More than 1600 Cesar A. Moran, Neda Kalhor, Annikka high-quality images assist in the understand- Weissferdt (Eds.) ing of cutaneous reaction patterns and diag- 2206 pages, 2689 illustrations, 250 €, nosis. Springer (2020) This text provides the necessary tools and up- Rapid On-Site Evaluation (ROSE) in Diag- to-date information on the morphological ap- nostic Interventional Pulmonology proach and most current use of ancillary tech- Volume 2: Interstitial Lung Diseases

Summer 2020

niques in the diagnosis and treatment of ma- The book covers all relevant topics of uropa- lignant tumors. The work is divided by sub- thology (tumoral and non-tumoral), from the specialty areas so that the reader can easily normal histology of the genitourinary tract to obtain the information desired. Features of pathological findings of diseases in the male histopathological lesions are presented in genital and urinary tract. To make the content each area, as well as an up-to-date use of the more accessible, all content is arranged al- different immunohistochemical stains and phabetically and each entry is uniformly struc- molecular biology features, when applicable, tured, presenting the epidemiology, the clini- which are commonly used to determine treat- cal signs, the gross and histological features, ment modalities. All subspecialty sections are the immunohistochemical stainings, and the written by subspecialty pathologists with ex- molecular data for each disease. Histological perience in tumor pathology and who work in pictures clarify the microscopic findings and a cancer center. Each chapter is richly illus- help readers understand the differential diag- trated and properly referenced. Oncological nosis for genitourinary tract diseases. Surgical Pathology will be of use not only for pathologists (including pathology residents Pulmonary Pathology and fellows), but also for oncological sur- A Practical Guide geons, oncologists and interventional radiolo- Helmut Popper, Bruno Murer gists. Series: Essentials of Diagnostic Pathology 597 pages, 1693 illustrations, 260 €, Histopathology Reporting. Guidelines for Springer (2020) Surgical Cancer This book provides an up-to-date overview of David P. Boyle, Derek C. Allen (Eds.) diagnostics in lung and pleura pathology. It 4th ed, 507 pages, 125 illustrations, 140 €, helps surgical and clinical pathologist solve Springer (2020) problem cases in lung and pleura tumor pa- This book is an easily comprehensible and thology as well as in other fields of pulmo- practicable framework for standardised histo- nary/pleura pathology such as interstitial lung pathology reports in surgical cancer. The disease, rare tumors, metabolic diseases, in- pathological features of the common carcino- fectious pneumonias, pneumoconiosis, drug mas are detailed and non-carcinomatous ma- induced lung diseases, developmental and lignancies are also summarised. 8th edition pediatric pulmonary pathology. Focusing on TNM and WHO classifications of cancers are practical issues and providing numerous illus- incorporated, with comments on any associ- trated examples of typical and atypical cases, ated pathology, diagnostic clues and prog- it guides residents as well as experienced nostic criteria supplemented visually by line pathologists through the problems and pitfalls diagrams. in pulmonary and pleura pathology. Refer- ences have been kept to a minimum. Uropathology Maria R. Raspollini, Antonio Lopez-Beltran Normal and Abnormal Prepuce (Eds.) Mohamed A. Baky Fahmy Series: Encyclopedia of Pathology 312 pages, 326 illustrations, 160 €, Springer 510 pages, 348 illustrations, 320 €, Springer (2020) (2020)

Summer 2020

This illustrative book discusses the normal five clearly defined categories, each de- embryology, anatomy, functions, normal vari- scribed by a specific term and each with a ations and diseases affecting the prepuce. It specific risk of malignancy. The five catego- also explores other rare anomalies and dis- ries are insufficient/inadequate, benign, atyp- eases of the prepuce as well as previously un- ical, suspicious of malignancy and malignant. reported cases. In addition to the male pre- Each category has a risk of malignancy and puce, the book also discusses the female pre- is linked to management recommendations, puce (hood) in order to elucidate some lights which include several options because it is in normal and abnormal prepuce. A separate recognized that diagnostic infrastructure, section covers the frenulum and its anoma- such as the availability of core needle biopsy lies. and ultrasound guidance, vary between de- Rich in illustrations this book will help paedia- veloped and low- and middle-income coun- tricians and urologists better understand the tries. This text includes key diagnostic cyto- anomalies of the prepuce. logical criteria for each of the many lesions and tumors found in the breast. The cyto- Tumors and Tumor-Like Lesions of Bone pathology of specific lesions is illustrated with Eduardo Santini-Araujo, Ricardo K. Kalil, high quality photomicrographs with clear fig- Franco Bertoni, Yong-Koo Park (Eds.) ure descriptions. Chapters also discuss cur- 2nd ed, 1002 pages, 1244 illustrations, 320 rent and potential future ancillary tests, liquid €, Springer (2020) based cytology, nipple cytology and manage- This updated second edition of a successful ment. An additional chapter provides an over- book provides essential, internationally appli- view of an approach to the diagnosis of direct cable information in the area of bone and joint smears of breast fine needle aspiration biop- pathology with emphasis on practical diag- sies. nostic aspects, including many illustrations: roentgenograms, CT-scans, MRI, scintigra- Diagnosis of Musculoskeletal Tumors and phies, as well as pictures of gross surgical Tumor-like Conditions specimens and microphotographs, immuno- Clinical, Radiological and Histological Corre- histochemical reactions and genomics. Infor- lations - The Rizzoli Case Archive mation on histopathological and molecular di- Piero Picci, Marco Manfrini, Davide M. agnosis, and basic therapeutic guidelines are Donati, Marco Gambarotti, Alberto Righi, provided. Daniel Vanel, Angelo P. Dei Tos, (Eds.) 2nd ed, 362 pages, 272 illustrations, 145 €, The International Academy of Cytology Springer (2020) Yokohama System for Reporting Breast This book, now in a second revised edition, Fine Needle Aspiration Biopsy Cyto- casts light on the often-complex diagnosis of pathology musculoskeletal tumors and tumor-like condi- Andrew Field, Wendy Raymond, Fernando tions by drawing on the experience of the Riz- Schmitt (Eds.) zoli Orthopedic Institute during more than 100 185 pages, 119 illus, 80 €, Springer (2020) years of treatment and research in the field. This text describes a system of reporting The different entities are described from a breast fine needle aspiration biopsy that uses multidisciplinary perspective, highlighting

Summer 2020

clinical, radiological, and histological correla- and their features as outlined in the text sec- tions. Particular emphasis is placed on differ- tion along with tables that highlight the differ- ential diagnosis, which often needs to take ential diagnoses and salient ancillary fea- into account nontumoral conditions. The re- tures. cent identification of further significant biolog- ical and genetic features, and the impact of Esophageal Cancer these discoveries on the classification of Prevention, Diagnosis and Therapy round cell tumors, vascular lesions, and spin- Nabil F. Saba, Bassel El-Rayes (Eds.) dle/pleomorphic entities in bone, is also ex- 2nd ed, 336 pages, 43 illustrations, 155 €, tensively discussed. The Rizzoli case archive Springer (2020) dates back to September 1900 and contains The second edition of this very successful the original material relating to more than book documents the latest progress in the 29,000 bone lesions and 11,000 soft tissue le- prevention, diagnosis and treatment of sions. It is a fabulously rich resource, and this esophageal cancer and includes additional book will be invaluable for pathologists, radi- sections covering novel targeted therapeutic ologists, and clinicians at all levels of experi- approaches, immunotherapy and palliative ence. and nutritional support for patients. Further- more, the sections covering epidemiology, Kidney Cancer molecular biology, pathology, staging and ra- Recent Advances in Surgical and Molecular diologic and endoscopic assessments have Pathology been thoroughly updated and expanded. The Mukul K. Divatia, Ayhan Ozcan, Charles C. principles of surgical resection, radiation ther- Guo, Jae Y. Ro (Eds.) apy and systemic therapy are reviewed and 445 pages, 192 illustrations, 135 €, Springer attention is paid to the multidisciplinary ap- (2020) proaches to the management of early stage This book provides a comprehensive over- cervical, thoracic, distal and junctional tu- view of pathology of kidney tumors along with mors. Updated information is also provided radiological features and up to date treatment on the treatment of metastatic and recurrent strategies that enable the readers to avail this disease as well as approaches that may im- information in day to day pathology sign-out pact future care, such as chemoprevention. as well as interaction with clinical colleagues Esophageal Cancer: Prevention, Diagnosis of different disciplines. It also serves as a re- and Therapy will assist specialists from vari- ferral resource for the current medical or sur- ous disciplines, including surgery, radiation gical practice while preparing for examina- therapy, gastroenterology, medical oncology tions or maintenance of certification. Written and palliative , in delivering optimal, by experts in the field, chapters contain an up- up-to-date care to the benefit of patients. dated review of important pathologic parame- ters mandated for diagnosis and reporting Tumors of the Uterine Corpus and Troph- with emphasis on updated information re- oblastic Diseases garding new developments in this interesting Esther Oliva, David C. Wilbur, Neil J. Sebire, field. Numerous high-resolution color images Robert A. Soslow aptly illustrate the various pathologic entities Series: AFIP Atlas of tumor pathology, Series 4

Summer 2020

520 pages, 200 €, American registry of Pa- thology (2020)

Since the publication of the Third Series Fas- cicle of the Uterine Corpus nearly thirty years ago, molecular discoveries have deepened our understanding of epithelial, mesenchy- mal, and mixed müllerian tumors of the uterus, fueling a new and still evolving classi- fication of the different categories of uterine neoplasms. Enormous insights have been made to refine the classification of the differ- ent subtypes of endometrial carcinoma linked to important prognostic and therapeutic impli- cations. At the same time, molecular findings have allowed for the discovery of familial syn- dromes associated with uterine corpus neo- plasms, and identification of patients at in- creased risk for developing specific tumors, with the subsequent implementation of ge- netic counseling and appropriate treatment guidelines. Molecular underpinnings have also assisted in the development of new and potentially more predictive morphologic crite- ria for endometrial preneoplasia, namely the endometrial intraepithelial neoplasia (or EIN) system.

Summer 2020

Glasgow 2020

Summer 2020