Interdry® Case Studies the Challenges of Skin Fold Management

Total Page:16

File Type:pdf, Size:1020Kb

Interdry® Case Studies the Challenges of Skin Fold Management InterDry® Case Studies The challenges of skin fold management Intertriginous dermatitis (intertrigo) is a common International Consensus Panel for Intertrigo1 agreed inflammatory skin condition. Skin-to-skin or skin-to-device powders such as cornstarch may encourage fungal contact may cause friction and can hold moisture against growth and have no proven benefit. Linen, gauze and the skin’s surface. This puts patients at risk for skin paper towels placed between skin folds are usually complications such as maceration, erythema, erosion, ineffective. These textiles absorb moisture; however, itching/burning, odor and pain. they do not allow the moisture to evaporate, thereby promoting skin damage. As a result, resolution is often Current treatments attempt to manage the symptoms not achieved and symptoms persist leading to more but do not solve the underlying cause. The 2013 serious complications.2 FIGURE 13 FIGURE 23 Candidal intertrigo Week 3 resolution of beneath both breasts candidal intertrigo at initial visit. beneath both breasts. Manage the cause, not only the symptoms By addressing the causes of skin fold maladies, InterDry® moisture-wicking fabric with antimicrobial silver is the first effective solution for managing complications associated with skin folds. MOISTURE FRICTION FUNGAL & BACTERIAL The soft, knitted 100% The polyurethane coating ORGANISMS polyester fabric wicks and reduces friction in skin folds. Ionic silver provides effective translocates excess moisture, broad-spectrum antimicrobial keeping the skin dry. action within the fabric for up to 5 days. References 1. Sibbald RG, Kelly J, Kennedy-Evans KL, Labrecque C, Waters N. A practical approach to the prevention and management of intertrigo, or moisture-associated skin damage, due to perspiration: expert consensus on best practice. Wound Care Canada - Supplement. 2013;11(2)1-21 2. Black JM, Gray M, Bliss DZ, Kennedy Evans KL, Logan S, Baharestani M, Colwell JC, Goldberg M, Ratcliff CR. MASD part 2: incontinence-associated dermatitis and intertriginous dermatitis: a consensus. J Wound Ostomy Continence Nurs. 2011;38(4):359-70 3. Vorbeck E. Evaluation of a skin fold management textile with antimicrobial silver in a variety of clinical situations. Unpublished case studies. 2007 2 InterDry® improves clinical outcomes Kennedy-Evans and colleagues1 performed a clinical study to determine the efficacy of the moisture-wicking fabric with silver in place of standard treatments. Twenty-one (21) subjects with intertriginous dermatitis from two long-term care centers were enrolled in the study. Reduction in itching/burning: Fifteen (15) subjects had 2 itching/burning on Day 1. On Day 5, zero (0) subjects 1.8 had itching/burning. There was a statistically significant reduction in itching/burning (P = .0001) by Day 3 and 1.6 (P < .0001) by Day 5. 1.416 Mean Score Day 1 Number of Patients 1.214 Day 3 Reduction in maceration: Ten (10) subjects had 1 Day 1 12 Day 5 maceration on Day 1. One (1) subject had maceration on Day 3 0.810 Day 3 and Day 5 resulting from textile becoming soiled Day 5 0.6 with urine and not removed immediately. 8 0.46 Reduction in denudement: Seven (7) subjects had 0.24 0 denudement on Day 1. On Day 5, two (2) subjects had 2 Erythema Odor denudement that was improving. There was a significant 0 reduction on Day 3 (P = .125) and on Day 5 (P = .062). 2 Itching/ Maceration Denudement Satellite Burning Lesions 1.8 Reduction in satellite lesions: Five (5) subjects had 1.6 satellite lesions on Day 1. On Day 3 and Day 5, one (1) subject had satellite lesions that were improving. 1.4 2 Mean Score 1.2 1.8 Day 1 Day 3 Reduction in erythema: All of the subjects (21) entered 1 1.6 Day 5 the study with erythema. There was a statistically 0.8 1.4 significant reduction in erythema P( < .0001) by Day 3 0.6 Mean Score 1.2 Day 1 and Day 5. Day 3 0.4 1 Day 5 Reduction in odor 0.2 0.8 Separated odor: Twelve (12) subjects had odor on Day 1. 0 0.6 Erythema Odor There was a statistically significant reduction in separated 0.4 odor (P = .0020) by Day 3 and (P = .0034) by Day 5. Two 0.2 (2) subjects with odor on Day 5 had improved significantly 0 from Day 1. Note: One (1) subject had no odor on Day 1 Erythema Odor and Day 3 and minimal odor (scarcely noticeable) on Day 5 due to the textile being soiled with urine and left in place. Closed odor: Closed odor was not statistically analyzed. One (1) subject had closed odor on Day 1. On Day 3 and Day 5, zero (0) subjects had closed odor. References 1. Kennedy-Evans KL, Viggiano B, Henn T, Smith D. Multi-site feasibility study using a new textile with silver for management of skin conditions located in skin folds. Poster presented at: 20th Annual Symposium on Advanced Wound Care; April 28 - May 1, 2007; Tampa, FL and 39th WOCN® Society Annual Conference; June 9-13, 2007; Salt Lake City, UT 3 Introduction to skin fold management Author: Susan Gallagher, PhD, MSN, MA, RN, CBN, HCRM, CSPHP Sponsored by Coloplast Historical challenges antibiotic use; immunosuppression; example, McMahon and others Over the past few decades healthcare immobility; and diabetes, especially in reported that in a survey of 1116 providers have struggled to address the presence of excess moisture. hospitalized female patients 11.2% issues of skin fold management. had active or resolved inframammary Powders and creams have been the Most agree a gender or ethnic/racial lesions. Researchers found the mainstay of treatment. More creative component doesn’t exist; however, prevalence was higher among elderly processes have included taping skin age may be a factor. The very old individuals or those with mental folds apart or placing flannel or cotton and very young typically are affected illness. Mathur and others describe a fabric between skin folds to more often because of reduced higher rate of ITD among obese discourage skin-to-skin contact. immunity, immobilization, and adolescents. Although the numbers Resolution of skin injury may be moisture. Further, in the aging of critically ill patients who achieved; however, the process has population, age-related tissue loss is experience ITD is not clear, been time consuming and costly. associated with ITD. For instance, as anecdotally, providers understand Historically, a solution to skin fold the mandible shrinks in elderly this is a high-risk group for several management had been elusive. persons and the vertical dimensions reasons. For instance, in the intensive decrease around the mouth, care areas patients generally Special patient populations inflammation and ITD can occur experience an increased exposure to From a clinical perspective, excess under and within the accentuated moisture due to increased moisture often leads to intertriginous nasolabial folds. ITD manifests in a perspiration associated with illness/ dermatitis (ITD), especially in the number of areas over the aging body. diseases, fever or medications. There presence of deep cutaneous folds. Digital ITD is not uncommon among is more opportunity for skin-to-skin Obesity is thought to be a primary individuals who have contractures contact while in the lying position and factor in the development of ITD due to stroke or any other condition an increase in skin friction with because the presence of skin folds that impairs use of the hands and movement in bed or perhaps places the patient at greater risk for fingers. Any area of the body where restriction of movement because of prolonged skin-to-skin contact. ITD there is prolonged skin-to-skin hemodynamic instability or often occurs among adults, children contact is vulnerable. All risk factors reluctance to move a complex, or infants who are obese or who are aggravated by hot and humid critically ill individual. have a weight maldistribution. conditions. Thus a regional factor Inflammation may develop under or exists as well as a patient population Clinical and economic concerns within abdominal folds, in neck component. Some experts contend that creases, or in popliteal or antecubital prevention is a more appropriate fossae. However, a number of Unfortunately, the true prevalence of alternative to treatment and different types of individuals can ITD in unknown in a general sense, recommend a number of preventive develop this condition. For example, research suggests that the issue is strategies. For example, patients are in addition to obesity, risk factors for pervasive among certain populations, advised to control blood sugar, use ITD include: hyperhidrosis; systemic and affected individuals do not cotton undergarments, lose weight, infection; chronic steroid and always seek medical treatment. For avoid tight clothing and avoid 4 unnecessary antibiotic or steroid use. improve. However, recurrence of ITD might include dressings, antibiotics, Experts suggest keeping the area dry is common. Recurrences lead to laboratory studies, home health or and exposed to the air as much as direct and indirect costs. Indirect acute care expenses not covered by possible to prevent recurrences. costs include time from work, home the patient’s insurance carrier and and family; travel time to providers; more. Skin fold management has As indicated in the McMahon study, embarrassment from odor; threats to become an ongoing struggle for many individuals have resolution of productivity due to discomfort; many individuals from a humanistic, the ITD once their general conditions frustration and more. Direct costs clinical and economic perspective. References 1. Del Rosso JQ, Draelos ZD, Jorizzo JL, Joseph WS, Ribotsky BM, Rich P. Modern methods to treat superficial fungal disease.Cutis . 2007;79(2 suppl):6-29 2. Guitart J, Woodley DT. Intertrigo: a practical approach. Compr Ther. 1994;20(7):402-409 3. Scott TD. Intertrigo.
Recommended publications
  • Seborrheic Dermatitis: an Overview ROBERT A
    Seborrheic Dermatitis: An Overview ROBERT A. SCHWARTZ, M.D., M.P.H., CHRISTOPHER A. JANUSZ, M.D., and CAMILA K. JANNIGER, M.D. University of Medicine and Dentistry at New Jersey-New Jersey Medical School, Newark, New Jersey Seborrheic dermatitis affects the scalp, central face, and anterior chest. In adolescents and adults, it often presents as scalp scaling (dandruff). Seborrheic dermatitis also may cause mild to marked erythema of the nasolabial fold, often with scaling. Stress can cause flare-ups. The scales are greasy, not dry, as commonly thought. An uncommon generalized form in infants may be linked to immunodeficiencies. Topical therapy primarily consists of antifungal agents and low-potency steroids. New topical calcineurin inhibitors (immunomodulators) sometimes are administered. (Am Fam Physician 2006;74:125-30. Copyright © 2006 American Academy of Family Physicians.) eborrheic dermatitis can affect patients levels, fungal infections, nutritional deficits, from infancy to old age.1-3 The con- neurogenic factors) are associated with the dition most commonly occurs in condition. The possible hormonal link may infants within the first three months explain why the condition appears in infancy, S of life and in adults at 30 to 60 years of age. In disappears spontaneously, then reappears adolescents and adults, it usually presents as more prominently after puberty. A more scalp scaling (dandruff) or as mild to marked causal link seems to exist between seborrheic erythema of the nasolabial fold during times dermatitis and the proliferation of Malassezia of stress or sleep deprivation. The latter type species (e.g., Malassezia furfur, Malassezia tends to affect men more often than women ovalis) found in normal dimorphic human and often is precipitated by emotional stress.
    [Show full text]
  • Hyperhidrosis: Sweating out the Details
    Focus on CME at the Université de Montréal Hyperhidrosis: Sweating Out the Details Antranik Benohanian, MD, FRCPC; and Nowell Solish, MD, FRCPC Presented at the 250th meeting of the Montreal Dermatological Society, April 2003 yperhidrosis (HH) remains a relatively Table 1 Hunknown disorder to the general public Most commonly affected sites and health-care professionals. According to the literature, 0.5% to 1% of the population is Site Prevalence affected by HH. However, a recent survey held Facial 68.9% in the U.S. places that figure at 2.8%; thus, Axillary 50.8% revealing that the prevalence is underrated. Plantar 28.7% Among those affected, only 38% had discussed Palmar 24.8% the problem with a health professional.1 HH may be classified as primary or sec- ondary; either type can be localized or gen- Besides affecting quality of life, HH predis- eralized. Table 1 lists the most commonly poses its victims to a host of dermatologic dis- affected sites. orders (Table 2).3 The control of HH would also control the associated disease condition, as has Impact on quality of life been recently reported with the treatment of dyshidrotic hand dermatitis with intradermal HH is known to be a socially embarrassing and botulinum toxin.4 occupationally disabling disorder. Many patients suffer in silence. Figure 1 illustrates the How is HH treated? impact HH has on quality of life.2 Those with axillary HH often have to change Systemic approach clothing several times a day and throw out Minor sedatives, such as amitriptyline and clothing because of the damage caused to fabric hydroxyzine, produce an anticholinergic, as and leather.
    [Show full text]
  • Pompholyx Factsheet Pompholyx Eczema (Also Known As Dyshidrotic Eczema/Dermatitis) Is a Type of Eczema That Usually Affects the Hands and Feet
    12 Pompholyx factsheet Pompholyx eczema (also known as dyshidrotic eczema/dermatitis) is a type of eczema that usually affects the hands and feet. In most cases, pompholyx eczema involves the development of intensely itchy, watery blisters, mostly affecting the sides of the fingers, the palms of the hands and soles of the feet. Some people have pompholyx eczema on their hands and/or feet with other types of eczema elsewhere on the body. This condition can occur at any age but is usually seen in adults under 40, and is more common in women. The skin is initially very itchy with a burning sensation of heat and prickling in the palms and/or soles. Then comes a sudden crop of small blisters (vesicles), which turn into bigger weepy blisters, which can become infected, causing redness, pain, swelling and pustules. There is often subsequent peeling as the skin dries out, and then the skin can become red and dry with painful cracks (skin fissures). Pompholyx eczema can also affect the nail folds and skin around the nails, causing swelling (paronychia). What causes it? A reaction could be the result of contact with potential irritants such as soap, detergents, solvents, acids/alkalis, The exact causes of pompholyx eczema are not known, chemicals and soil, causing irritant contact dermatitis. Or although it is thought that factors such as stress, there could be an allergic reaction to a substance that is sensitivity to metal compounds (such as nickel, cobalt or not commonly regarded as an irritant, such as rubber or chromate), heat and sweating can aggravate this nickel, causing allergic contact dermatitis.
    [Show full text]
  • Blockage of Neddylation Modification Stimulates Tumor Sphere Formation
    Blockage of neddylation modification stimulates tumor PNAS PLUS sphere formation in vitro and stem cell differentiation and wound healing in vivo Xiaochen Zhoua,b,1, Mingjia Tanb,1, Mukesh K. Nyatib, Yongchao Zhaoc,d, Gongxian Wanga,2, and Yi Sunb,c,e,2 aDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; bDivision of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109; cInstitute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; dKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; and eCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, China Edited by Vishva M. Dixit, Genentech, San Francisco, CA, and approved March 10, 2016 (received for review November 13, 2015) MLN4924, also known as pevonedistat, is the first-in-class inhibitor acting alone or in combination with current chemotherapy of NEDD8-activating enzyme, which blocks the entire neddylation and/or radiation (6, 11). One of the seven clinical trials of MLN4924 modification of proteins. Previous preclinical studies and current (NCT00911066) was published recently, concluding a modest effect clinical trials have been exclusively focused on its anticancer property. of MLN4924 against acute myeloid leukemia (AML) (12). Unexpectedly, we show here, to our knowledge for the first time, To further elucidate the role of blocking neddylation in cancer that MLN4924, when applied at nanomolar concentrations, signif- treatment, we thought to study the effect of MLN4924 on cancer icantly stimulates in vitro tumor sphere formation and in vivo stem cells (CSCs) or tumor-initiating cells (TICs), a small group tumorigenesis and differentiation of human cancer cells and mouse of tumor cells with stem cell properties that have been claimed to embryonic stem cells.
    [Show full text]
  • Atopic Dermatitis 101 for Adults
    TRIGGER TRACKER Atopic Dermatitis 101 for Adults WHAT IS ATOPIC DERMATITIS? IS THERE A CURE? Atopic dermatitis (AD) is the most common type There is no cure for of eczema. It often appears as a red, itchy rash or atopic dermatitis yet, dry, scaly patches on the skin. AD usually begins but there are treatments in infancy or childhood but can develop at any available and more are on the way. point in a person’s lifetime. It commonly shows up on the face, inside of the elbows or behind the WHAT ARE MY TREATMENT OPTIONS? knees, but it can appear anywhere on the body. It is important to have a regular schedule with AD care that includes bathing with a gentle IS IT CONTAGIOUS ? cleanser and moisturizing to lock water into the You can’t catch atopic dermatitis or spread it to skin and repair the skin barrier. Moisturized skin others. helps control flares by combating dryness and keeping out irritants and allergens. WHAT CAUSED IT? Depending on severity of symptoms and age, AD While the exact cause is unknown, researchers do treatments include lifestyle changes, over-the- know that people develop atopic dermatitis counter (OTC) and natural remedies, prescription because of a combination of genes and a trigger. topical medications, which are applied to the People with AD tend to have an over-reactive immune system that when triggered by skin; biologics, given by injection; something outside or inside the body, responds immunosuppressants, usually taken by mouth in by producing inflammation. It is this inflammation the form of a pill; and phototherapy, a form of that causes red, itchy and painful skin symptoms.
    [Show full text]
  • Medicare 2019 Part C & D Star Ratings Cut Point Trends
    Trends in Part C & D Star Rating Measure Cut Points Updated – 12/19/2018 (Last Updated 12/19/2018) Page 1 Document Change Log Previous Revision Version Description of Change Date - Final release of the 2019 Star Ratings Cut Point Trend document 12/19/2018 (Last Updated 12/19/2018) Page i Table of Contents DOCUMENT CHANGE LOG .............................................................................................................................. I TABLE OF CONTENTS .................................................................................................................................... II INTRODUCTION ............................................................................................................................................... 1 PART C MEASURES ........................................................................................................................................ 2 Measure: C01 - Breast Cancer Screening ........................................................................................................................ 2 Measure: C02 - Colorectal Cancer Screening .................................................................................................................. 3 Measure: C03 - Annual Flu Vaccine .................................................................................................................................. 4 Measure: C04 - Improving or Maintaining Physical Health ...........................................................................................
    [Show full text]
  • Long-Lasting Muscle Thinning Induced by Infrared Irradiation Specialized with Wavelengths and Contact Cooling: a Preliminary Report
    Long-Lasting Muscle Thinning Induced by Infrared Irradiation Specialized With Wavelengths and Contact Cooling: A Preliminary Report Yohei Tanaka, MD, Kiyoshi Matsuo, MD, PhD, and Shunsuke Yuzuriha, MD, PhD Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan Correspondence: [email protected] Published May 28, 2010 Objective: Infrared (IR) irradiation specialized with wavelengths and contact cooling increases the amount of water in the dermis to protect the subcutaneous tissues against IR damage; thus, it is applied to smooth forehead wrinkles. However, this treatment consistently induces brow ptosis. Therefore, we investigated whether IR irradiation induces muscle thinning. Methods: Rat central back tissues were irradiated with the specialized IR device. Histological evaluation was performed on sagittal slices that included skin, panniculus carnosus, and deep muscles. Results: Significant reductions in panniculus carnosus thickness were observed between controls and irradiated tissues at postirradiation day 30 (P30), P60, P90, and P180; however, no reduction was observed in nonirradiated controls from days 0 to 180. No significant changes were observed in the trunk muscle over time. From day 0, dermal thickness was significantly reduced at P90 and P180; however, no difference was observed between P180 and nonirradiated controls at day 180. DNA degradation consistent with apoptosis was detected in the panniculus carnosus at P7 and P30. Conclusions: We found that IR irradiation induced long-lasting superficial muscle thinning, probably by a kind of apoptosis. The panniculus carnosus is equivalent to the superficial facial muscles of humans; thus, the changes observed here reflected those in the frontalis muscle that resulted in brow ptosis.
    [Show full text]
  • Thermo-Responsive Poly(N-Isopropylacrylamide)- Cellulose Nanocrystals Hybrid Hydrogels for Wound Dressing
    Article Thermo-Responsive Poly(N-Isopropylacrylamide)- Cellulose Nanocrystals Hybrid Hydrogels for Wound Dressing Katarzyna Zubik 1, Pratyawadee Singhsa 1,2, Yinan Wang 1, Hathaikarn Manuspiya 2 and Ravin Narain 1,* 1 Department of Chemical and Materials Engineering, Donadeo Innovation Centre in Engineering, 116 Street and 85 Avenue, Edmonton, AB T6G 2G6, Canada; [email protected] (K.Z.); [email protected] (P.S.); [email protected] (Y.W.) 2 The Petroleum and Petrochemical College, Center of Excellence on Petrochemical and Materials Technology, Chulalongkorn University, Soi Chulalongkorn 12, Pathumwan, Bangkok 10330, Thailand; [email protected] * Correspondence: [email protected]; Tel.: +1-780-492-1736 Academic Editor: Shiyong Liu Received: 29 January 2017; Accepted: 21 March 2017; Published: 24 March 2017 Abstract: Thermo-responsive hydrogels containing poly(N-isopropylacrylamide) (PNIPAAm), reinforced both with covalent and non-covalent interactions with cellulose nanocrystals (CNC), were synthesized via free-radical polymerization in the absence of any additional cross-linkers. The properties of PNIPAAm-CNC hybrid hydrogels were dependent on the amounts of incorporated CNC. The thermal stability of the hydrogels decreased with increasing CNC content. The rheological measurement indicated that the elastic and viscous moduli of hydrogels increased with the higher amounts of CNC addition, representing stronger mechanical properties of the hydrogels. Moreover, the hydrogel injection also supported the hypothesis that CNC reinforced the hydrogels; the increased CNC content exhibited higher structural integrity upon injection. The PNIPAAm- CNC hybrid hydrogels exhibited clear thermo-responsive behavior; the volume phase transition temperature (VPTT) was in the range of 36 to 39 °C, which is close to normal human body temperature.
    [Show full text]
  • Fundamentals of Dermatology Describing Rashes and Lesions
    Dermatology for the Non-Dermatologist May 30 – June 3, 2018 - 1 - Fundamentals of Dermatology Describing Rashes and Lesions History remains ESSENTIAL to establish diagnosis – duration, treatments, prior history of skin conditions, drug use, systemic illness, etc., etc. Historical characteristics of lesions and rashes are also key elements of the description. Painful vs. painless? Pruritic? Burning sensation? Key descriptive elements – 1- definition and morphology of the lesion, 2- location and the extent of the disease. DEFINITIONS: Atrophy: Thinning of the epidermis and/or dermis causing a shiny appearance or fine wrinkling and/or depression of the skin (common causes: steroids, sudden weight gain, “stretch marks”) Bulla: Circumscribed superficial collection of fluid below or within the epidermis > 5mm (if <5mm vesicle), may be formed by the coalescence of vesicles (blister) Burrow: A linear, “threadlike” elevation of the skin, typically a few millimeters long. (scabies) Comedo: A plugged sebaceous follicle, such as closed (whitehead) & open comedones (blackhead) in acne Crust: Dried residue of serum, blood or pus (scab) Cyst: A circumscribed, usually slightly compressible, round, walled lesion, below the epidermis, may be filled with fluid or semi-solid material (sebaceous cyst, cystic acne) Dermatitis: nonspecific term for inflammation of the skin (many possible causes); may be a specific condition, e.g. atopic dermatitis Eczema: a generic term for acute or chronic inflammatory conditions of the skin. Typically appears erythematous,
    [Show full text]
  • “The Red Face” and More Clinical Pearls
    “The Red Face” and More Clinical Pearls Courtney R. Schadt, MD, FAAD Assistant Professor Residency Program Director University of Louisville Associates in Dermatology I have no disclosures or conflicts of interest Part 1: The Red Face: Objectives • Distinguish and diagnose common eruptions of the face • Recognize those with potential implications for internal disease • Learn basic treatment options Which patient(s) has an increased risk of hypertension and hyperlipidemia? A B C Which patient(s) has an increased risk of hypertension and hyperlipidemia? A Seborrheic Dermatitis B C Psoriasis Seborrheic Dermatitis Goodheart HP. Goodheart's photoguide of common skin disorders, 2nd ed, Lippincott Williams & Wilkins, Philadelphia 2003. Copyright © 2003 Lippincott Williams & Wilkins. Seborrheic Dermatitis • Erythematous scaly eruption • Infants= “Cradle Cap” • Reappear in adolescence or later in life • Chronic, remissions and flares; worse with stress, cold weather • Occurs on areas of body with increased sebaceous glands • Unclear role of Malassezia; could be immune response; no evidence of overgrowth Seborrheic Dermatitis Severe Seb Derm: THINK: • HIV (can also be more diffuse on trunk) • Parkinson’s (seb derm improves with L-dopa therapy) • Other neurologic disorders • Neuroleptic agents • Unclear etiology 5MinuteClinicalConsult Clinical Exam • Erythema/fine scale • Scalp • Ears • Nasolabial folds • Beard/hair bearing areas Goodheart HP. Goodheart's photoguide of common skin disorders, 2nd ed, Lippincott • Ill-defined Williams & Wilkins, Philadelphia
    [Show full text]
  • High-Dose Chemotherapy Less Frequent Catheter Dressing Changes
    Bone Marrow Transplantation (2002) 29, 653–658 2002 Nature Publishing Group All rights reserved 0268–3369/02 $25.00 www.nature.com/bmt High-dose chemotherapy Less frequent catheter dressing changes decrease local cutaneous toxicity of high-dose chemotherapy in children, without increasing the rate of catheter-related infections: results of a randomised trial E Benhamou1, E Fessard2, C Com-Nougue´1,3, PS Beaussier2, G Nitenberg4, C Tancre`de5, S Dodeman2 and O Hartmann2 1Department of Biostatistics and Epidemiology, Institut Gustave Roussy, Villejuif, France; 2Department of Pediatrics, Institut Gustave Roussy, Villejuif, France; 3Pierre et Marie Curie University, Paris, France; 4Intensive Care Unit, Institut Gustave Roussy, Villejuif, France; and 5Department of Microbiology, Institut Gustave Roussy, Villejuif, France Summary: In our hospital, patients treated with high-dose chemo/radiotherapy (HDC) regimens followed by bone Cutaneous lesions caused by catheter dressing changes marrow transplantation (BMT) are fitted with a central can be serious and generate local pain in children venous catheter which is usually inserted a few days before undergoing high-dose chemotherapy followed by bone hospitalisation in the transplantation unit. Usually, central marrow transplantation. One hundred and thirteen venous catheter dressings are changed, empirically, every children entered a randomised trial to compare two 3 or 4 days,1,2 whatever the state of the dressing and mostly catheter dressing change frequencies (15 days vs 4 days). because less frequent changes are suspected of promoting Skin toxicity was classified according to the following local infections likely to give rise to bacteraemia in granul- scale: grade 0: healthy skin, to grade 4: severe skin tox- ocytopenic patients.
    [Show full text]
  • Table S1. Checklist for Documentation of Google Trends Research
    Table S1. Checklist for Documentation of Google Trends research. Modified from Nuti et al. Section/Topic Checklist item Search Variables Access Date 11 February 2021 Time Period From January 2004 to 31 December 2019. Query Category All query categories were used Region Worldwide Countries with Low Search Excluded Volume Search Input Non-adjusted „Abrasion”, „Blister”, „Cafe au lait spots”, „Cellulite”, „Comedo”, „Dandruff”, „Eczema”, „Erythema”, „Eschar”, „Freckle”, „Hair loss”, „Hair loss pattern”, „Hiperpigmentation”, „Hives”, „Itch”, „Liver spots”, „Melanocytic nevus”, „Melasma”, „Nevus”, „Nodule”, „Papilloma”, „Papule”, „Perspiration”, „Petechia”, „Pustule”, „Scar”, „Skin fissure”, „Skin rash”, „Skin tag”, „Skin ulcer”, „Stretch marks”, „Telangiectasia”, „Vesicle”, „Wart”, „Xeroderma” Adjusted Topics: "Scar" + „Abrasion” / „Blister” / „Cafe au lait spots” / „Cellulite” / „Comedo” / „Dandruff” / „Eczema” / „Erythema” / „Eschar” / „Freckle” / „Hair loss” / „Hair loss pattern” / „Hiperpigmentation” / „Hives” / „Itch” / „Liver spots” / „Melanocytic nevus” / „Melasma” / „Nevus” / „Nodule” / „Papilloma” / „Papule” / „Perspiration” / „Petechia” / „Pustule” / „Skin fissure” / „Skin rash” / „Skin tag” / „Skin ulcer” / „Stretch marks” / „Telangiectasia” / „Vesicle” / „Wart” / „Xeroderma” Rationale for Search Strategy For Search Input The searched topics are related to dermatologic complaints. Because Google Trends enables to compare only five inputs at once we compared relative search volume of all topics with topic „Scar” (adjusted data). Therefore,
    [Show full text]