Structure and Properties of Vitamins
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
University of Birmingham the Potential Impact of Essential
University of Birmingham The Potential Impact of Essential Nutrients Vitamins C and D upon Periodontal Disease Pathogenesis and Therapeutic Outcomes Brock, Gareth; Chapple, Iain DOI: 10.1007/s40496-016-0116-9 License: None: All rights reserved Document Version Peer reviewed version Citation for published version (Harvard): Brock, G & Chapple, I 2016, 'The Potential Impact of Essential Nutrients Vitamins C and D upon Periodontal Disease Pathogenesis and Therapeutic Outcomes', Current Oral Health Reports, vol. 3, no. 4, pp. 337-346. https://doi.org/10.1007/s40496-016-0116-9 Link to publication on Research at Birmingham portal General rights Unless a licence is specified above, all rights (including copyright and moral rights) in this document are retained by the authors and/or the copyright holders. The express permission of the copyright holder must be obtained for any use of this material other than for purposes permitted by law. •Users may freely distribute the URL that is used to identify this publication. •Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research. •User may use extracts from the document in line with the concept of ‘fair dealing’ under the Copyright, Designs and Patents Act 1988 (?) •Users may not further distribute the material nor use it for the purposes of commercial gain. Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive. -
Routine Administration of Vitamin K1 Prophylaxis to the Newborn
Routine Administration of Vitamin K1 Prophylaxis to the Newborn Practice Resource for Health Care Providers July 2016 Practice Resource Guide: ROUTINE ADMINISTRATION OF VITAMIN K1 PROPHYLAXIS TO THE NEWBORN The information attached is the summary of the position statement and the recommendations from the recent CPS evidence-based guideline for routine intramuscular administration of Vitamin K1 prophylaxis to the newborn*: www.cps.ca/documents/position/administration-vitamin-K-newborns Summary Vitamin K deficiency bleeding or VKDB (formerly known as hemorrhagic disease of the newborn or HDNB) is significant bleeding which results from the newborn’s inability to sufficiently activate vitamin K-dependent coagulation factors because of a relative endogenous and exogenous deficiency of vitamin K.1 There are three types of VKDB: 1. Early onset VKDB, which appears within the first 24 hours of life, is associated with maternal medications that interfere with vitamin K metabolism. These include some anticonvulsants, cephalosporins, tuberculostatics and anticoagulants. 2. Classic VKDB appears within the first week of life, but is rarely seen after the administration of vitamin K. 3. Late VKDB appears within three to eight weeks of age and is associated with inadequate intake of vitamin K (exclusive breastfeeding without vitamin K prophylaxis) or malabsorption. The incidence of late VKDB has increased in countries that implemented oral vitamin K rather than intramuscular administration. There are three methods of Vitamin K1 administration: intramuscular, oral and intravenous. The Canadian Paediatric Society (2016)2 and the American Academy of Pediatrics (2009)3 recommend the intramuscular route of vitamin K administration. The intramuscular route of Vitamin K1 has been the preferred method in North America due to its efficacy and high compliance rate. -
Dispensing of Vitamin Products by Retail Pharmacies in South Africa: Implications for Dietitians
South African Journal of Clinical Nutrition 2016; 29(4):133–138 http://dx.doi.org/10.1080/16070658.2016.1219468 SAJCN ISSN 1607-0658 EISSN 2221-1268 Open Access article distributed under the terms of the © 2016 The Author(s) Creative Commons License [CC BY-NC 3.0] http://creativecommons.org/licenses/by-nc/3.0 RESEARCH Dispensing of vitamin products by retail pharmacies in South Africa: Implications for dietitians Ilse Trutera* and Liana Steenkampb a Department of Pharmacy, Drug Utilisation Research Unit (DURU), Nelson Mandela Metropolitan University, Port Elizabeth, South Africa b HIV & AIDS Research Unit, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa *Corresponding author, email: [email protected] Objective: The objective of this study was to analyse the dispensing patterns of vitamins (Anatomical Therapeutic Chemical (ATC) group A11) over a one-year period in a group of community pharmacies in South Africa. Design and setting: A retrospective drug utilisation study was conducted on community pharmacy electronic dispensing records in South Africa recorded in 2013. Outcome measures: All products for ATC subgroup A11 were extracted and analysed. Results: A total of 164 233 vitamin products were dispensed to 84 805 patients (62.64% female patients). Males received on average 2.09 (SD = 2.63) vitamin products per year, compared to 1.84 (SD = 2.13) products for females. Ergocalciferol (A11CC01) was the most often dispensed (37.48% of all vitamin products), followed by plain Vitamin B-complex products (A11EA00) accounting for 32.77%. Ergocalciferol (vitamin D2) is only available on prescription (50 000 IU tablets or 50 000 IU/ml oily drops) in South Africa. -
Carotenoid Oxidation Products Are Stress Signals That Mediate Gene Responses to Singlet Oxygen in Plants
Carotenoid oxidation products are stress signals that mediate gene responses to singlet oxygen in plants Fanny Ramela,b,c, Simona Birtica,b,c, Christian Giniesd, Ludivine Soubigou-Taconnate, Christian Triantaphylidèsa,b,c, and Michel Havauxa,b,c,1 aCommissariat à l’Energie Atomique et aux Energies Alternatives, Direction des Sciences du Vivant, Institut de Biologie Environnementale et Biotechnologie, Laboratoire d’Ecophysiologie Moléculaire des Plantes, F-13108 Saint-Paul-lez-Durance, France; bCentre National de la Recherche Scientifique, Unité Mixte de Recherche Biologie Végétale et Microbiologie Environnementales, F-13108 Saint-Paul-lez-Durance, France; cUniversité Aix-Marseille, F-13108 Saint-Paul-lez- Durance, France; dInstitut National de la Recherche Agronomique, Unité Mixte de Recherche 408 SQPOV, Université d’Avignon et des Pays de Vaucluse, F-84000 Avignon, France; and eGénomiques Fonctionnelles d’Arabidopsis, Unité de Recherche en Génomique Végétale, Unité Mixte de Recherche Institut National de la Recherche Agronomique 1165, Equipe de Recherche Labellisée Centre National de la Recherche Scientifique 8196, Université d’Evry Val d’Essonne, 91057 Evry, France Edited by Krishna K. Niyogi, University of California, Berkeley, CA, and accepted by the Editorial Board February 23, 2012 (received for review September 29, 2011) 1 O2 (singlet oxygen) is a reactive O2 species produced from triplet toxicity (4, 10, 11) and, therefore, products resulting from their 1 excited chlorophylls in the chloroplasts, especially when plants are direct oxidation by O2 are potential candidates for this function. exposed to excess light energy. Similarly to other active O2 species, This possibility is explored in the present work. 1 O2 has a dual effect: It is toxic, causing oxidation of biomolecules, and it can act as a signal molecule that leads to cell death or to Results 1 1 acclimation. -
Vitamin K: Double Bonds Beyond Coagulation Insights Into Differences Between Vitamin K1 and K2 in Health and Disease
International Journal of Molecular Sciences Review Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease Maurice Halder 1,†, Ploingarm Petsophonsakul 2,†, Asim Cengiz Akbulut 2,†, Angelina Pavlic 2,† , Frode Bohan 3, Eric Anderson 3, Katarzyna Maresz 4, Rafael Kramann 1 and Leon Schurgers 1,2,* 1 Division of Nephrology, RWTH Aachen University, 52074 Aachen, Germany; [email protected] (M.H.); [email protected] (R.K.) 2 Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200MD Maastricht, The Netherlands; [email protected] (P.P.); [email protected] (A.C.A.); [email protected] (A.P.) 3 NattoPharma ASA, 0283 Oslo, Norway; [email protected] (F.B.); [email protected] (E.A.) 4 International Science & Health Foundation, 30-134 Krakow, Poland; [email protected] * Correspondence: [email protected]; Tel.: +31-43-3881680; Fax: +31-43-3884159 † These authors contributed equally to this work. Received: 24 January 2019; Accepted: 16 February 2019; Published: 19 February 2019 Abstract: Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K can be present in various isoforms, distinguishable by two main structures, namely, phylloquinone (K1) and menaquinones (K2). The difference in structure between K1 and K2 is seen in different absorption rates, tissue distribution, and bioavailability. Although differing in structure, both act as cofactor for the enzyme gamma-glutamylcarboxylase, encompassing both hepatic and extrahepatic activity. Only carboxylated proteins are active and promote a health profile like hemostasis. Furthermore, vitamin K2 in the form of MK-7 has been shown to be a bioactive compound in regulating osteoporosis, atherosclerosis, cancer and inflammatory diseases without risk of negative side effects or overdosing. -
Folic Acid, Pyridoxine, and Cyanocobalamin Combination
ORIGINAL INVESTIGATION Folic Acid, Pyridoxine, and Cyanocobalamin Combination Treatment and Age-Related Macular Degeneration in Women The Women’s Antioxidant and Folic Acid Cardiovascular Study William G. Christen, ScD; Robert J. Glynn, ScD; Emily Y. Chew, MD; Christine M. Albert, MD; JoAnn E. Manson, MD Background: Observational epidemiologic studies indi- and visually significant AMD, defined as confirmed in- cate a direct association between homocysteine concentra- cident AMD with visual acuity of 20/30 or worse attrib- tion in the blood and the risk of age-related macular degen- utable to this condition. eration (AMD), but randomized trial data to examine the effect of therapy to lower homocysteine levels in AMD are Results:Afteranaverageof7.3yearsoftreatmentandfollow- lacking. Our objective was to examine the incidence of AMD up, there were 55 cases of AMD in the combination treat- in a trial of combined folic acid, pyridoxine hydrochloride ment group and 82 in the placebo group (relative risk, 0.66; (vitamin B6), and cyanocobalamin (vitamin B12) therapy. 95% confidence interval, 0.47-0.93 [P=.02]). For visually significant AMD, there were 26 cases in the combination Methods: We conducted a randomized, double-blind, treatment group and 44 in the placebo group (relative risk, placebo-controlled trial including 5442 female health care 0.59; 95% confidence interval, 0.36-0.95 [P=.03]). professionals 40 years or older with preexisting cardio- vascular disease or 3 or more cardiovascular disease risk Conclusions: These randomized trial data from a large factors. A total of 5205 of these women did not have a cohort of women at high risk of cardiovascular disease diagnosis of AMD at baseline and were included in this indicate that daily supplementation with folic acid, pyri- analysis. -
Vitamins Minerals Nutrients
vitamins minerals nutrients Vitamin B12 (Cyanocobalamin) Snapshot Monograph Vitamin B12 Nutrient name(s): (Cyanocobalamin) Vitamin B12 Most Frequent Reported Uses: Cyanocobalamin • Homocysteine regulation Methylcobalamin • Neurological health, including Adenosylcobalamin (Cobamamide) diabetic neuropathy, cognitive Hydroxycobalamin (European) function, vascular dementia, stroke prevention • Anemias, including pernicious and megaloblastic • Sulfite sensitivity Cyanocobalamin Introduction: Vitamin B12 was isolated from liver extract in 1948 and reported to control pernicious anemia. Cobalamin is the generic name of vitamin B12 because it contains the heavy metal cobalt, which gives this water-soluble vitamin its red color. Vitamin B12 is an essential growth factor and plays a role in the metabolism of cells, especially those of the gastrointestinal tract, bone marrow, and nervous tissue. Several different cobalamin compounds exhibit vitamin B12 activity. The most stable form is cyanocobalamin, which contains a cyanide group that is well below toxic levels. To become active in the body, cyanocobalamin must be converted to either methylcobalamin or adenosylcobalamin. Adenosylcobalamin is the primary form of vitamin B12 in the liver. © Copyright 2013, Integrative Health Resources, LLC | www.metaboliccode.com A protein in gastric secretions called intrinsic factor binds to vitamin B12 and facilitates its absorption. Without intrinsic factor, only a small percentage of vitamin B12 is absorbed. Once absorbed, relatively large amounts of vitamin B12 can be stored in the liver. The body actually reabsorbs vitamin B12 in the intestines and returns much of it to the liver, allowing for very little to be excreted from the body. However, when there are problems in the intestines, such as the microflora being imbalanced resulting in gastrointestinal inflammation, then vitamin B12 deficiencies can occur. -
Synergistic Antitumor Activity of Vitamins C and K3 on Human Bladder Cancer Cell Lines
Journal of Cancer Therapy, 2013, 4, 7-19 http://dx.doi.org/10.4236/jct.2013.46A3002 Published Online February 2013 (http://www.scirp.org/journal/jct) Synergistic Antitumor Activity of Vitamins C and K3 on Human Bladder Cancer Cell Lines Karen McGuire1, James M. Jamison1*, Jacques Gilloteaux2, Jack L. Summers1 1The Apatone Development Center, St. Thomas Hospital, Summa Health System, Akron, USA; 2Department of Anatomical Sciences, St Georges’ University International School of Medicine, K B Taylor Scholar’s Programme, Newcastle upon Tyne, UK. Email: *[email protected] Received April 24th, 2013; revised May 26th, 2013; accepted June 3rd, 2013 Copyright © 2013 Karen McGuire et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Exponentially growing cultures of human bladder tumor cells (RT4 and T24) were treated with Vitamin C (VC) alone, Vitamin K3 (VK3) alone, or with a VC:VK3 combination continuously for 5 days or treated with vitamins for 1 h, washed with PBS and then incubated in culture medium for 5 days. Co-administration of the vitamins enhanced the antitumor activity 12- to 24-fold for the RT-4 cells and 6- to 41-fold for the T24 cells. Flow cytometry of RT4 cells ex- posed to the vitamins revealed a growth arrested population and a population undergoing cell death. Growth arrested cells were blocked near the G0/G1-S-phase interface, while cell death was due to autoschizis. Catalase treatment abro- gated both cell cycle arrest and cell death which implicated hydrogen peroxide (H2O2) in these processes. -
Ionones When Used As Fragrance Ingredients Q
Available online at www.sciencedirect.com Food and Chemical Toxicology 45 (2007) S130–S167 www.elsevier.com/locate/foodchemtox Review A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients q The RIFM Expert Panel D. Belsito a, D. Bickers b, M. Bruze c, P. Calow d, H. Greim e, J.M. Hanifin f, A.E. Rogers g, J.H. Saurat h, I.G. Sipes i, H. Tagami j a University of Missouri (Kansas City), c/o American Dermatology Associates, LLC, 6333 Long Avenue, Third Floor, Shawnee, KS 66216, USA b Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Avenue, New York, NY 10032, USA c Lund University, Malmo University Hospital, Department of Occupational and Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden d Institut for Miliovurdering, Environmental Assessment Institute, Linne´sgade 18, First Floor, Copenhagen 1361 K, Denmark e Technical University of Munich, Institute for Toxicology and Environmental Hygiene, Hohenbachernstrasse 15-17, Freising-Weihenstephan D-85354, Germany f Oregon Health Sciences University, Department of Dermatology L468, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA g Boston University School of Medicine, Department of Pathology and Laboratory Medicine, 715 Albany Street, L-804, Boston, MA 02118-2526, USA h Hospital Cantonal Universitaire, Clinique et Policlinique de Dermatologie, 24, Rue Micheli-du-Crest, Geneve 14 1211, Switzerland i Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA j 3-27-1 Kaigamori, Aoba-ku, Sendai 981-0942, Japan Abstract An evaluation and review of a structurally related group of fragrance materials. -
Guidelines on Food Fortification with Micronutrients
GUIDELINES ON FOOD FORTIFICATION FORTIFICATION FOOD ON GUIDELINES Interest in micronutrient malnutrition has increased greatly over the last few MICRONUTRIENTS WITH years. One of the main reasons is the realization that micronutrient malnutrition contributes substantially to the global burden of disease. Furthermore, although micronutrient malnutrition is more frequent and severe in the developing world and among disadvantaged populations, it also represents a public health problem in some industrialized countries. Measures to correct micronutrient deficiencies aim at ensuring consumption of a balanced diet that is adequate in every nutrient. Unfortunately, this is far from being achieved everywhere since it requires universal access to adequate food and appropriate dietary habits. Food fortification has the dual advantage of being able to deliver nutrients to large segments of the population without requiring radical changes in food consumption patterns. Drawing on several recent high quality publications and programme experience on the subject, information on food fortification has been critically analysed and then translated into scientifically sound guidelines for application in the field. The main purpose of these guidelines is to assist countries in the design and implementation of appropriate food fortification programmes. They are intended to be a resource for governments and agencies that are currently implementing or considering food fortification, and a source of information for scientists, technologists and the food industry. The guidelines are written from a nutrition and public health perspective, to provide practical guidance on how food fortification should be implemented, monitored and evaluated. They are primarily intended for nutrition-related public health programme managers, but should also be useful to all those working to control micronutrient malnutrition, including the food industry. -
Potato - Analysis of Nutrients by Veronica Öhrvik, Irene Mattisson, Sören Wretling and Christina Åstrand
Rapport 19 − 2010 Potato - analysis of nutrients by Veronica Öhrvik, Irene Mattisson, Sören Wretling and Christina Åstrand LIVSMEDELS VERKET NATIONAL FOOD ADMINISTRATION, Sweden Content Summary .................................................................................................................................... 2 Background ................................................................................................................................ 3 Materials and methods ............................................................................................................... 4 Sampling potatoes .................................................................................................................. 4 Varieties ............................................................................................................................. 4 Geographical distribution ................................................................................................... 5 Catering potato ................................................................................................................... 5 Sample handling ..................................................................................................................... 7 Quality assurance of analytical methods ................................................................................ 8 Analysed nutrients .................................................................................................................. 9 Calculation of nutritional -
Vitamin and Mineral Safety 3Rd Edition (2013) Council for Responsible Nutrition (CRN)
EXCERPTED FROM: Vitamin and Mineral Safety 3rd Edition (2013) Council for Responsible Nutrition (CRN) www.crnusa.org Vitamin B12 Introduction Vitamin B12 helps maintain the body’s nervous system and blood cells and supports the production of DNA. Vitamin B12 also helps prevents a type of anemia and has been termed the “anti-pernicious anemia dietary factor.” Vitamin B12 is also the only known physiologically important compound that contains cobalt, and therefore the various forms of vitamin B12 are known collectively as cobalamins. Vitamin B12 is a cofactor in two enzymes that are fundamental in facilitating growth in humans. In the methylcobalamin form, vitamin B12 is the direct cofactor for methionine synthetase, the enzyme that recycles homocysteine back to methionine. Here, vitamin B12 and folic acid have closely related roles in one-carbon metabolism. In the adenosylcobalamin form, vitamin B12 is the cofactor in methylmalonyl-coenzyme A mutase. Both reactions are involved in promoting the rapid growth and proliferation of bone marrow cells and ultimately red blood cells (Expert Group on Vitamins and Minerals [EVM] 2003). Vitamin B12 is essential for the function and maintenance of the central nervous system, and severe deficiency in persons with pernicious anemia produces the neurological disease of posterolateral spinal cord degeneration (Herbert and Das 1994). The direct cause of pernicious anemia, in fact, is vitamin B12 deficiency, but the underlying defect is the absence of an intrinsic factor produced by specific stomach cells and needed for intestinal absorption of vitamin B12. Without this intrinsic factor, absorption is greatly reduced or fails, and a severe and persistent deficiency develops that is not preventable by the usual dietary levels of vitamin B12.