Schneider's First-Rank Symptoms As Predictors of Remission in Antipsychotic-Naive First-Episode Psychosis
Braz J Psychiatry. 2020 Jan-Feb;42(1):22-26 doi:10.1590/1516-4446-2018-0237 Brazilian Psychiatric Association 00000000-0002-7316-1185 ORIGINAL ARTICLE Schneider’s first-rank symptoms as predictors of remission in antipsychotic-naive first-episode psychosis Fernando R. Malinowski,1,2*0000-0000-0000-0000 Brazilio de C. Tasso,3* Bruno B. Ortiz,1,2 Cinthia H. Higuchi,1 Cristiano Noto,1,20000-0000-0000-0000 Sintia I. Belangero,1 Rodrigo A. Bressan,1 Ary Gadelha,1,2 Quirino Cordeiro4 1Laborato´rio Interdisciplinar de Neurocieˆncias Clı´nicas (LiNC), Departamento de Psiquiatria, Universidade Federal de Sa˜o Paulo (UNIFESP), Sa˜o Paulo, SP, Brazil. 2Programa de Esquizofrenia (PROESQ), Departamento de Psiquiatria, UNIFESP, Sa˜o Paulo, SP, Brazil. 3Central Hospital, Centro de Atenc¸a˜o Integrada a` Sau´de Mental (CAISM), Complexo Hospitalar do Juquery, Franco da Rocha, SP, Brazil. 4Departamento de Psiquiatria, Irmandade da Santa Casa de Miserico´rdia de Sa˜o Paulo (ISCMSP), Sa˜o Paulo, SP, Brazil. *These authors have contributed equally to this manuscript. Objective: German psychiatrist Kurt Schneider proposed the concept of first-rank symptoms (FRS) of schizophrenia in 1959. However, their relevance for diagnosis and prediction of treatment response are still unclear. Most studies have investigated FRS in chronic or medicated patients. The present study sought to evaluate whether FRS predict remission, response, or improvement in functionality in antipsychotic-naive first-episode psychosis. Methods: Follow-up study of 100 patients at first episode of psychosis (FEP), with no previous treatment, assessed at baseline and after 2 months of treatment. The participants were evaluated with the standardized Positive and Negative Syndrome Scale (PANSS) and Global Assessment of Functioning (GAF) and for presence of FRS.
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