CURRICULUM VITAE Family Name : SIPROUDHIS First Name : LAURENT Date of Birth : 19/03/1960 Present Position : Physician in chief of the Gastroenteroloy Unit Name/Address of Hospital /Country : Gastroenterology unit Pontchaillou university hospital 35033 Rennes cedex 09 France Phone Number :0033299284311 Fax Number : 0033299284189 Doctor of Medicine. Graduation Date : 1989 University : Rennes Registration Number (CNOM): 35/03689 Is Number Still Valid ? yes FINESS: 350005179 RPPS: 10002643848 Post graduation : Other Medical or Professional Training : MD. Certification in Gastroenterology and Hepatology. PhD in Life Science and Development. Master in Medical management and communication. Hospital Titles and Activities : Hospital Site location: Pontchaillou university Hospital Rennes France Institutional implications : Clinical Research unit, Gastroenterology unit, Endoscopy unit, Intensive Care unit, Anorectal and Perineology unit, General Surgery Unit. Activities: endoscopy, anorectal surgery, anorectal physiology, ultrasound and defecography. University Site location: University of Medicine Rennes France Institutional implications: Second and third cycles Teachings. Scientific and redaction committees (Gastorenterol Clin Biol, Le Courrier de Colo Proctologie, La lettre d’Hépato Gastroenterologie, Colon&rectum Proktos.com). Research Site location: University of Medicine Rennes France Implications: Prospective evaluations and National coordination, several randomized controlled studies as main investigator, best recruitment centre in the three last multicenter randomized controlled studies. Past President of the Clinical Research Comittee of CHU Rennes institution between 2007 and 2012. Member of the National Research Group of Proctology since 2004. Publications 1: Bouguen G, Laharie D, Nancey S, Hebuterne X, Flourie B, Filippi J, Roblin X, Trang C, Bourreille A, Babouri A, Bretagne JF, Siproudhis L, Peyrin-Biroulet L. Efficacy and Safety of Adalimumab 80 mg Weekly in Luminal Crohn's Disease. Inflamm Bowel Dis. 2015 Mar 23. [Epub ahead of print] PubMed PMID: 25803504. 2: Dupin C, Siproudhis L, Henno S, Minjolle S, Arvieux C, Tattevin P. Use of human papillomavirus genotyping and biomarkers for targeted screening of anal dysplasia in human immunodeficiency virus-infected patients. Dig Liver Dis. 2015 Jan 29. pii: S1590-8658(15)00173-5. doi: 10.1016/j.dld.2015.01.150. [Epub ahead of print] PubMed PMID: 25682992. 3: Gautier M, Godeberge P, Ganansia R, Bozio G, Godart B, Bigard MA, Barthet M, Siproudhis L; For the Groupe de Recherche en Proctologie SNFCP France. Easy clip to treat anal fistula tracts: a word of caution. Int J Colorectal Dis. 2015 Feb 13. [Epub ahead of print] PubMed PMID: 25675886. 4: Peyronnet B, Bendavid C, Manunta A, Damphousse M, Cheensse C, Brochard C, Castel-Lacanal E, Siproudhis L, Bensalah K, Gamé X. [The role of urinary markers in the assessment and follow-up of lower urinary tract disorders: A literature review]. Prog Urol. 2015 Mar;25(4):188-99. doi: 10.1016/j.purol.2014.11.004. Epub 2014 Nov 18. French. PubMed PMID: 25482921. 5: Vinson-Bonnet B, Higuero T, Faucheron JL, Senejoux A, Pigot F, Siproudhis L. Ambulatory haemorrhoidal surgery: systematic literature review and qualitative analysis. Int J Colorectal Dis. 2015 Apr;30(4):437-45. doi: 10.1007/s00384-014-2073-x. Epub 2014 Nov 28. PubMed PMID: 25427629. 6: Garros A, Siproudhis L, Tchoundjeu B, Rohou T, Brochard C, Wallenhorst T, Bretagne JF, Bouguen G. Magnetic resonance imaging and clinical assessments for perianal Crohn's disease: gain and limits. Dig Liver Dis. 2014 Dec;46(12):1072-6. doi: 10.1016/j.dld.2014.08.003. Epub 2014 Sep 2. PubMed PMID: 25192603. 7: Brochard C, Siproudhis L, Wallenhorst T, Cuen D, d'Halluin PN, Garros A, Bretagne JF, Bouguen G. Anorectal stricture in 102 patients with Crohn's disease: natural history in the era of biologics. Aliment Pharmacol Ther. 2014 Oct;40(7):796-803. doi: 10.1111/apt.12894. Epub 2014 Aug 11. PubMed PMID: 25109493. 8: Aguilar C, Lenoir C, Lambert N, Bègue B, Brousse N, Canioni D, Berrebi D, Roy M, Gérart S, Chapel H, Schwerd T, Siproudhis L, Schäppi M, Al-Ahmari A, Mori M, Yamaide A, Galicier L, Neven B, Routes J, Uhlig HH, Koletzko S, Patel S, Kanegane H, Picard C, Fischer A, Bensussan NC, Ruemmele F, Hugot JP, Latour S. Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers. J Allergy Clin Immunol. 2014 Nov;134(5):1131-41.e9. doi: 10.1016/j.jaci.2014.04.031. Epub 2014 Jun 15. PubMed PMID: 24942515. 9: Legros L, Ropert A, Brochard C, Bouguen G, Pagenault M, Siproudhis L, Bretagne JF. Long-term results of pneumatic dilatation for relapsing symptoms of achalasia after Heller myotomy. Neurogastroenterol Motil. 2014 Sep;26(9):1248-55. doi: 10.1111/nmo.12380. Epub 2014 Jun 11. PubMed PMID: 24916630. 10: Vitton V, Soudan D, Siproudhis L, Abramowitz L, Bouvier M, Faucheron JL, Leroi AM, Meurette G, Pigot F, Damon H; French National Society of Coloproctology. Treatments of faecal incontinence: recommendations from the French national society of coloproctology. Colorectal Dis. 2014 Mar;16(3):159-66. doi: 10.1111/codi.12410. PubMed PMID: 24521273. 11: Siproudhis L, Jones D, Shing RN, Walker D, Scholefield JH; Libertas Study Consortium. Libertas: rationale and study design of a multicentre, Phase II, double-blind, randomised, placebo-controlled investigation to evaluate the efficacy, safety and tolerability of locally applied NRL001 in patients with faecal incontinence. Colorectal Dis. 2014 Mar;16 Suppl 1:59-66. doi: 10.1111/codi.12546. PubMed PMID: 24499497. 12: Damon H, Siproudhis L, Faucheron JL, Piche T, Abramowitz L, Eléouet M, Etienney I, Godeberge P, Valancogne G, Denis A, Mion F, Schott AM; Oralia Trial Group. Perineal retraining improves conservative treatment for faecal incontinence: a multicentre randomized study. Dig Liver Dis. 2014 Mar;46(3):237-42. doi: 10.1016/j.dld.2013.11.002. Epub 2014 Jan 17. PubMed PMID: 24444704. 13: Bouguen G, Ropert A, Lainé F, Pequin P, Morcet J, Bretagne JF, Siproudhis L. Effects of transcutaneous tibial nerve stimulation on anorectal physiology in fecal incontinence: a double-blind placebo-controlled cross-over evaluation. Neurogastroenterol Motil. 2014 Feb;26(2):247-54. doi: 10.1111/nmo.12256. Epub 2013 Nov 7. PubMed PMID: 24304363. 14: Beaugerie L, Carrat F, Colombel JF, Bouvier AM, Sokol H, Babouri A, Carbonnel F, Laharie D, Faucheron JL, Simon T, de Gramont A, Peyrin-Biroulet L; CESAME Study Group. Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer. Gut. 2014 Sep;63(9):1416-23. doi: 10.1136/gutjnl-2013-305763. Epub 2013 Oct 25. PubMed PMID: 24162591. 15: Cunin D, Siproudhis L, Desfourneaux V, Berkelmans I, Meunier B, Bretagne JF, Bouguen G. No surgery for full-thickness rectal prolapse: what happens with continence? World J Surg. 2013 Jun;37(6):1297-302. doi: 10.1007/s00268-013-1967-z. PubMed PMID: 23440486. 16: Desgrippes R, Beauchamp C, Henno S, Bouguen G, Siproudhis L, Bretagne JF. Prevalence and predictive factors of the need for surgery for advanced colorectal adenoma. Colorectal Dis. 2013 Jun;15(6):683-8. doi: 10.1111/codi.12122. PubMed PMID: 23398651. 17: Bouguen G, Siproudhis L, Gizard E, Wallenhorst T, Billioud V, Bretagne JF, Bigard MA, Peyrin-Biroulet L. Long-term outcome of perianal fistulizing Crohn's disease treated with infliximab. Clin Gastroenterol Hepatol. 2013 Aug;11(8):975-81.e1-4. doi: 10.1016/j.cgh.2012.12.042. Epub 2013 Jan 30. PubMed PMID: 23376316. 18: Leroi AM, Siproudhis L, Etienney I, Damon H, Zerbib F, Amarenco G, Vitton V, Faucheron JL, Thomas C, Mion F, Roumeguère P, Gourcerol G, Bouvier M, Lallouche K, Menard JF, Queralto M. Transcutaneous electrical tibial nerve stimulation in the treatment of fecal incontinence: a randomized trial (CONSORT 1a). Am J Gastroenterol. 2012 Dec;107(12):1888-96. doi: 10.1038/ajg.2012.330. Epub 2012 Oct 2. PubMed PMID: 23032981. 19: Cunin D, Siproudhis L, Desfourneaux V, Bouteloup PY, Meunier B, Ropert A, Berkelmans I, Bretagne JF, Boudjema K, Bouguen G. Incontinence in full-thickness rectal prolapse: low level of improvement after laparoscopic rectopexy. Colorectal Dis. 2013 Apr;15(4):470-6. doi: 10.1111/codi.12027. PubMed PMID: 22966956. 20: Sokol H, Beaugerie L, Maynadié M, Laharie D, Dupas JL, Flourié B, Lerebours E, Peyrin-Biroulet L, Allez M, Simon T, Carrat F, Brousse N; CESAME Study Group. Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2012 Nov;18(11):2063-71. doi: 10.1002/ibd.22889. Epub 2012 Jan 23. PubMed PMID: 22271569. 21: Peyrin-Biroulet L, Khosrotehrani K, Carrat F, Bouvier AM, Chevaux JB, Simon T, Carbonnel F, Colombel JF, Dupas JL, Godeberge P, Hugot JP, Lémann M, Nahon S, Sabaté JM, Tucat G, Beaugerie L; Cesame Study Group. Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology. 2011 Nov;141(5):1621-28.e1-5. doi: 10.1053/j.gastro.2011.06.050. Epub 2011 Jun 25. PubMed PMID: 21708105. 22: Favreau C, Siproudhis L, Eleouet M, Bouguen G, Bretagne JF. Underlying functional bowel disorder may explain patient dissatisfaction after haemorrhoidal surgery. Colorectal Dis. 2012 Mar;14(3):356-61. doi: 10.1111/j.1463-1318.2011.02612.x. PubMed PMID: 21689305. 23: Abramowitz L, Jacquard AC, Jaroud F, Haesebaert J, Siproudhis L, Pradat P, Aynaud O, Leocmach Y, Soubeyrand B, Dachez R, Riethmuller D, Mougin C, Pretet JL, Denis F. Human papillomavirus genotype distribution in anal cancer in France: the EDiTH V study. Int J Cancer. 2011 Jul 15;129(2):433-9. doi: 10.1002/ijc.25671. Epub 2010 Nov 9. PubMed PMID: 20839262. 24: Eléouet M, Siproudhis L, Guillou N, Le Couedic J, Bouguen G, Bretagne JF. Chronic posterior tibial nerve transcutaneous electrical nerve stimulation (TENS) to treat fecal incontinence (FI). Int J Colorectal Dis. 2010 Sep;25(9):1127-32. doi: 10.1007/s00384-010-0960-3. Epub 2010 Jun 5. PubMed PMID: 20549220. 25: Bouguen G, Siproudhis L, Bretagne JF, Bigard MA, Peyrin-Biroulet L. Nonfistulizing perianal Crohn's disease: clinical features, epidemiology, and treatment. Inflamm Bowel Dis. 2010 Aug;16(8):1431-42. doi: 10.1002/ibd.21261. Review. PubMed PMID: 20310013. 26: Gallas S, Michot F, Faucheron JL, Meurette G, Lehur PA, Barth X, Damon H, Mion F, Rullier E, Zerbib F, Sielezneff I, Ouaïssi M, Orsoni P, Desfourneaux V, Siproudhis L, Mathonnet M, Menard JF, Leroi AM; Club NEMO. Predictive factors for successful sacral nerve stimulation in the treatment of faecal incontinence: results of trial stimulation in 200 patients. Colorectal Dis. 2011 Jun;13(6):689-96. doi: 10.1111/j.1463- 1318.2010.02260.x. Epub 2010 Mar 10. PubMed PMID: 20236144. 27: Bouguen G, Roblin X, Bourreille A, Feier L, Filippi J, Nancey S, Bretagne JF, Flourié B, Hébuterne X, Bigard MA, Siproudhis L, Peyrin- Biroulet L. Infliximab for refractory ulcerative proctitis. Aliment Pharmacol Ther. 2010 Jun;31(11):1178-85. doi: 10.1111/j.1365- 2036.2010.04293.x. Epub 2010 Mar 8. PubMed PMID: 20222911. 28: Grimaud JC, Munoz-Bongrand N, Siproudhis L, Abramowitz L, Sénéjoux A, Vitton V, Gambiez L, Flourié B, Hébuterne X, Louis E, Coffin B, De Parades V, Savoye G, Soulé JC, Bouhnik Y, Colombel JF, Contou JF, François Y, Mary JY, Lémann M; Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif. Fibrin glue is effective healing perianal fistulas in patients with Crohn's disease. Gastroenterology. 2010 Jun;138(7):2275-81, 2281.e1. doi: 10.1053/j.gastro.2010.02.013. Epub 2010 Feb 20. PubMed PMID: 20178792. 29: Beaugerie L, Brousse N, Bouvier AM, Colombel JF, Lémann M, Cosnes J, Hébuterne X, Cortot A, Bouhnik Y, Gendre JP, Simon T, Maynadié M, Hermine O, Faivre J, Carrat F; CESAME Study Group. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet. 2009 Nov 7;374(9701):1617-25. doi: 10.1016/S0140- 6736(09)61302-7. PubMed PMID: 19837455. 30: Siproudhis L, Eléouet M, Desfourneaux V, Abittan S, Bretagne JF. [Diagnosis of dyschezia]. Gastroenterol Clin Biol. 2009 Oct;33(10-11 Suppl):F68-74. doi: 10.1016/j.gcb.2009.07.025. Epub 2009 Sep 15. French. PubMed PMID: 19758775. 31: Bigard MA, Siproudhis L. [Anorectal disease: past, present, future]. Gastroenterol Clin Biol. 2009 Aug-Sep;33(8-9):713-23. doi: 10.1016/j.gcb.2009.07.013. Epub 2009 Aug 13. French. PubMed PMID: 19682811. 32: Bouguen G, Trouilloud I, Siproudhis L, Oussalah A, Bigard MA, Bretagne JF, Peyrin-Biroulet L. Long-term outcome of non-fistulizing (ulcers, stricture) perianal Crohn's disease in patients treated with infliximab. Aliment Pharmacol Ther. 2009 Oct;30(7):749-56. doi: 10.1111/j.1365- 2036.2009.04089.x. Epub 2009 Jul 6. PubMed PMID: 19583709. 33: Leroi AM, Damon H, Faucheron JL, Lehur PA, Siproudhis L, Slim K, Barbieux JP, Barth X, Borie F, Bresler L, Desfourneaux V, Goudet P, Huten N, Lebreton G, Mathieu P, Meurette G, Mathonnet M, Mion F, Orsoni P, Parc Y, Portier G, Rullier E, Sielezneff I, Zerbib F, Michot F; Club NEMO. Sacral nerve stimulation in faecal incontinence: position statement based on a collective experience. Colorectal Dis. 2009 Jul;11(6):572-83. doi: 10.1111/j.1463-1318.2009.01914.x. Epub 2009 Apr 15. PubMed PMID: 19508514. 34: Bouguen G, Eléouet M, Favreau C, Siproudhis L. [Anal fissure]. Rev Prat. 2008 Oct 31;58(16):1769-73. French. PubMed PMID: 19143148. 35: Siproudhis L, Eléouet M, Rousselle A, El Alaoui M, Ropert A, Bretagne JF. Overt rectal prolapse and fecal incontinence. Dis Colon Rectum. 2008 Sep;51(9):1356-60. doi: 10.1007/s10350-008-9353-x. Epub 2008 Jun 11. PubMed PMID: 18546040. 36: Sabate JM, Veyrac M, Mion F, Siproudhis L, Ducrotte P, Zerbib F, Grimaud JC, Dapoigny M, Dyard F, Coffin B. Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2008 Aug 15;28(4):484-90. doi: 10.1111/j.1365-2036.2008.03759.x. Epub 2008 Jun 9. PubMed PMID: 18544074; PubMed Central PMCID: PMC2696685. 37: Damon H, Schott AM, Barth X, Faucheron JL, Abramowitz L, Siproudhis L, Fayard MO, Colin C, Valancogne G, Bonniaud V, Mion F; French ORALIA Group. Clinical characteristics and quality of life in a cohort of 621 patients with faecal incontinence. Int J Colorectal Dis. 2008 Sep;23(9):845-51. doi: 10.1007/s00384-008-0489-x. Epub 2008 May 28. PubMed PMID: 18506453. 38: Dabadie A, Troadec F, Heresbach D, Siproudhis L, Pagenault M, Bretagne JF. Transition of patients with inflammatory bowel disease from pediatric to adult care. Gastroenterol Clin Biol. 2008 May;32(5 Pt 1):451-9. doi: 10.1016/j.gcb.2008.01.044. Epub 2008 May 8. PubMed PMID: 18472377. 39: Siproudhis L, Eléouet M, Abittan S. [Treatment of recurrent anal fissures: what should be done?]. Gastroenterol Clin Biol. 2008 May;32(5 Pt 2):S215-20. doi: 10.1016/j.gcb.2008.04.013. Epub 2008 May 7. French. PubMed PMID: 18467054. 40: Meurette G, Siproudhis L, Regenet N, Frampas E, Proux M, Lehur PA. Poor symptomatic relief and quality of life in patients treated for "solitary rectal ulcer syndrome without external rectal prolapse". Int J Colorectal Dis. 2008 May;23(5):521-6. doi: 10.1007/s00384-008-0445-9. Epub 2008 Feb 15. PubMed PMID: 18274765. 41: Siproudhis L. [Questions to Professor Laurent Siproudhis]. Gastroenterol Clin Biol. 2007 Nov;31(11):999-1001. French. PubMed PMID: 18166894. 42: Bouguen G, Manfredi S, Blayau M, Dugast C, Buecher B, Bonneau D, Siproudhis L, David V, Bretagne JF. Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics. Dis Colon Rectum. 2007 Oct;50(10):1612-7. PubMed PMID: 17674103. 43: Pequin P, Manfredi S, Quentin V, Heresbach D, Boyer J, Siproudhis L, Bretagne JF. Patients with sporadic duodenal adenoma are a high- risk group for advanced colorectal neoplasia: results of a case-control study. Aliment Pharmacol Ther. 2007 Jul 15;26(2):277-82. PubMed PMID: 17593073. 44: de Lajarte-Thirouard AS, Decaux O, Siproudhis L, Turlin B. [A unusual perianal ulcer]. Ann Pathol. 2007 Feb;27(1):57-8. French. PubMed PMID: 17568364. 45: Siproudhis L, Morcet J, Lainé F. Elastomer implants in faecal incontinence: a blind, randomized placebo-controlled study. Aliment Pharmacol Ther. 2007 May 1;25(9):1125-32. PubMed PMID: 17439514. 46: Pigot F, Siproudhis L, Bigard MA, Staumont G. Ano-rectal complaints in general practitioner visits: consumer point of view. Gastroenterol Clin Biol. 2006 Dec;30(12):1371-4. PubMed PMID: 17211335. 47: Le Tallec de Certaines H, Veillard D, Dugast J, Estèbe JP, Kerdraon J, Toulouse P, Siproudhis L, Brissot R. [Comparison between the terminal motor pudendal nerve terminal motor latency, the localization of the perineal neuralgia and the result of infiltrations. Analysis of 53 patients]. Ann Readapt Med Phys. 2007 Mar;50(2):65-9. Epub 2006 Aug 30. French. PubMed PMID: 17000020. 48: Daniel F, de Parades V, Siproudhis L, Atienza P. [Botulinum toxin and chronic anal fissure]. Gastroenterol Clin Biol. 2006 May;30(5):687-95. Review. French. PubMed PMID: 16801892. 49: Daniel F, Siproudhis L, Tohme C, Sayegh R. Solitary rectal ulcer: another view of the management algorithm. Gastrointest Endosc. 2006 Apr;63(4):738-9; author reply 739-40. PubMed PMID: 16564903. 50: Pigot F, Siproudhis L, Allaert FA. Risk factors associated with hemorrhoidal symptoms in specialized consultation. Gastroenterol Clin Biol. 2005 Dec;29(12):1270-4. PubMed PMID: 16518286. 51: Siproudhis L. [Eulogy of baroque proctology]. Gastroenterol Clin Biol. 2006 Jan;30(1):158-9. French. PubMed PMID: 16514405. 52: Siproudhis L, Vilotte J. [Who suffers from fecal incontinence?]. Gastroenterol Clin Biol. 2006 Jan;30(1):7-8. French. PubMed PMID: 16514375. 53: Siproudhis L, Pigot F, Godeberge P, Damon H, Soudan D, Bigard MA. Defecation disorders: a French population survey. Dis Colon Rectum. 2006 Feb;49(2):219-27. PubMed PMID: 16362804. 54: Siproudhis L, El Abkari M, El Alaoui M, Juguet F, Bretagne JF. Low rectal volumes in patients suffering from fecal incontinence: what does it mean? Aliment Pharmacol Ther. 2005 Nov 15;22(10):989-96. PubMed PMID: 16268974. 55: Morio O, Meurette G, Desfourneaux V, D'Halluin PN, Bretagne JF, Siproudhis L. Anorectal physiology in solitary ulcer syndrome: a case- matched series. Dis Colon Rectum. 2005 Oct;48(10):1917-22. PubMed PMID: 16132482. 56: Lechaux D, Trebuchet G, Siproudhis L, Campion JP. Laparoscopic rectopexy for full-thickness rectal prolapse: a single-institution retrospective study evaluating surgical outcome. Surg Endosc. 2005 Apr;19(4):514-8. Epub 2005 Mar 11. PubMed PMID: 15759180. 57: Ducrotte P, Dapoigny M, Bonaz B, Siproudhis L. Symptomatic efficacy of beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled trial. Aliment Pharmacol Ther. 2005 Feb 15;21(4):435-44. PubMed PMID: 15709995. 58: Siproudhis L, Dinasquet M, Sébille V, Reymann JM, Bellissant E. Differential effects of two types of antidepressants, amitriptyline and fluoxetine, on anorectal motility and visceral perception. Aliment Pharmacol Ther. 2004 Sep 15;20(6):689-95. PubMed PMID: 15352918. 59: Slim K, Siproudhis L. [Anal fissure. Which first line treatment?]. Ann Chir. 2004 Jun;129(5):290-2. Review. French. PubMed PMID: 15220104. 60: Schott AM, Damon H, Mion F, Siproudhis L. A randomized controlled trial of biofeedback that does not have the power to conclude. Gastroenterology. 2004 May;126(5):1496-7; author reply 1497. PubMed PMID: 15131826. 61: Heresbach D, Gicquel-Douabin V, Birebent B, D'halluin PN, Heresbach-Le Berre N, Dreano S, Siproudhis L, Dabadie A, Gosselin M, Mosser J, Semana G, Bretagne JF, Yaouanq J. NOD2/CARD15 gene polymorphisms in Crohn's disease: a genotype- phenotype analysis. Eur J Gastroenterol Hepatol. 2004 Jan;16(1):55-62. PubMed PMID: 15095853. 62: Siproudhis L, Sébille V, Pigot F, Hémery P, Juguet F, Bellissant E. Lack of effficacy of botulinum toxin in chronic anal fissure. Aliment Pharmacol Ther. 2003 Sep 1;18(5):515-24. PubMed PMID: 12950424. 63: Siproudhis L. [A "helping hand": an ordinary clinical story]. Gastroenterol Clin Biol. 2003 May;27(5 Suppl):B140-2. French. PubMed PMID: 12843948. 64: Siproudhis L, Delvaux M, Chaussade S, Charles F, Guyot P, Weber J, Fioramonti J, Ottignon Y, Zerbib F, Dyard F. [Patient-doctor relationship in the irritable bowel syndrome. Results of a French prospective study on the influence of the functional origin of the complaints]. Gastroenterol Clin Biol. 2002 Dec;26(12):1125-33. French. PubMed PMID: 12520201. 65: Siproudhis L, Corbinais S, Bicheler V. [Comment on case report: A difficult mourning period]. Gastroenterol Clin Biol. 2001 Nov;25(11):989- 91. French. PubMed PMID: 11845050. 66: Jugde F, Alizadeh M, Boissier C, Chantry D, Siproudhis L, Corbinais S, Quelvennec E, Dyard F, Campion JP, Gosselin M, Bretagne JF, Sémana G, Heresbach D. Quantitation of chemokines (MDC, TARC) expression in mucosa from Crohn's disease and ulcerative colitis. Eur Cytokine Netw. 2001 Jul-Sep;12(3):468-77. PubMed PMID: 11566628. 67: Siproudhis L. [Recent advances in treatment of anal diseases (except Crohn's disease)]. Gastroenterol Clin Biol. 2001 Apr;25(4 Suppl):B101-9. Review. French. PubMed PMID: 11449150. 68: Coat N, Le Berre-Heresbach N, Poinsignon Y, Rioux-Leclercq N, Turlin B, Siproudhis L, Caulet-Maugendre S, Bretagne JF, Gosselin M, Heresbach D. [Crohn's disease complicated by multiple and recurrent aseptic splenic abscesses]. Gastroenterol Clin Biol. 2001 Apr;25(4):425- 8. French. PubMed PMID: 11449131. 69: Siproudhis L. [Circular anopexia: a new approach to surgical treatment of hemorrhoid disease]. Gastroenterol Clin Biol. 2000 Nov;24(11):1137-8. French. PubMed PMID: 11221692. 70: Siproudhis L, Bellissant E, Pagenault M, Mendler MH, Allain H, Bretagne JF, Gosselin M. Fecal incontinence with normal anal canal pressures: where is the pitfall? Am J Gastroenterol. 1999 Jun;94(6):1556-63. PubMed PMID: 10364025. 71: Siproudhis L, Bellissant E, Juguet F, Allain H, Bretagne JF, Gosselin M. Perception of and adaptation to rectal isobaric distension in patients with faecal incontinence. Gut. 1999 May;44(5):687-92. PubMed PMID: 10205206; PubMed Central PMCID: PMC1727504. 72: Siproudhis L, Mahmoud H, Briand N, Juguet F, Bretagne JF, Allain H, Gosselin M. [Causal assessment of drug-induced acute colitis. A prospective study of 58 consecutive cases]. Gastroenterol Clin Biol. 1998 Oct;22(10):778-84. French. PubMed PMID: 9854202. 73: Siproudhis L, Bellissant E, Juguet F, Mendler MH, Allain H, Bretagne JF, Gosselin M. Rectal adaptation to distension in patients with overt rectal prolapse. Br J Surg. 1998 Nov;85(11):1527-32. PubMed PMID: 9823917. 74: Siproudhis L, Bellissant E, Juguet F, Allain H, Bretagne JF, Gosselin M. Octreotide acts on anorectal physiology: a dynamic study in healthy subjects. Clin Pharmacol Ther. 1998 Oct;64(4):424-32. PubMed PMID: 9797799. 75: Siproudhis L. [Therapeutic approaches to rectal prolapse]. Gastroenterol Clin Biol. 1998 Jun;22(5 Suppl):B134-41. Review. French. PubMed PMID: 9762321. 76: Siproudhis L. [Which techniques are useful for diagnosis of colonic cancer and for therapeutic choice?]. Gastroenterol Clin Biol. 1998 Mar;22(3 Suppl):S226-35. French. PubMed PMID: 9762259. 77: Siproudhis L, Bellissant E, Juguet F, Allain H, Bretagne JF, Gosselin M. Effects of cholinergic agents on anorectal physiology. Aliment Pharmacol Ther. 1998 Aug;12(8):747-54. PubMed PMID: 9726388. 78: Siproudhis L, Mortaji A, Mary JY, Juguet F, Bretagne JF, Gosselin M. Anal lesions: any significant prognosis in Crohn's disease? Eur J Gastroenterol Hepatol. 1997 Mar;9(3):239-43. PubMed PMID: 9096423. 79: Siproudhis L, Dautrème S, Ropert A, Briand H, Renet C, Beusnel C, Juguet F, Rabot AF, Bretagne JF, Gosselin M. Anismus and biofeedback: who benefits? Eur J Gastroenterol Hepatol. 1995 Jun;7(6):547-52. PubMed PMID: 7552638. 80: Siproudhis L, Beuchard J, Bretagne JF, Gosselin M. [Drug-induced enterocolitis (non-steroidal anti-inflammatory agents excluded)]. Gastroenterol Clin Biol. 1995;19(5 Pt 2):B71-8. French. PubMed PMID: 8522106. 81: Vilotte J, Merrouche M, Sobhani I, Siproudhis L, Benhamou G, Mignon M. [Female dyschesia, functional associations and pelvic disorders]. Presse Med. 1994 May 21;23(19):886-90. French. PubMed PMID: 7937617. 82: Heresbach D, Boutroux D, Bretagne JF, Raoul JL, Siproudhis L, Lebert P, Nicol M, Gosselin M. [Is the identification of acute biliary and alcoholic pancreatitis by early pancreatic enzyme assay possible?]. Gastroenterol Clin Biol. 1994;18(2):135-40. French. PubMed PMID: 7516903. 83: Heresbach D, Raoul JL, Genetet N, Noret P, Siproudhis L, Ramée MP, Bretagne JF, Gosselin M. Immunological study in primary intestinal lymphangiectasia. Digestion. 1994;55(1):59-64. PubMed PMID: 7509299. 84: Siproudhis L, Dautrème S, Ropert A, Bretagne JF, Heresbach D, Raoul JL, Gosselin M. Dyschezia and rectocele--a marriage of convenience? Physiologic evaluation of the rectocele in a group of 52 women complaining of difficulty in evacuation. Dis Colon Rectum. 1993 Nov;36(11):1030-6. PubMed PMID: 8223055. 85: Siproudhis L, Ropert A, Gosselin A, Bretagne JF, Heresbach D, Raoul JL, Gosselin M. Constipation after rectopexy for rectal prolapse. Where is the obstruction? Dig Dis Sci. 1993 Oct;38(10):1801-8. PubMed PMID: 8404400. 86: Heresbach D, Bretagne JF, Raoul JL, Moisan A, Siproudhis L, Devillers A, Gosselin M. Indium scanning in assessment of acute Crohn's disease. A prospective study of sensitivity and correlation with severity of mucosal damage. Dig Dis Sci. 1993 Sep;38(9):1601-7. PubMed PMID: 8359070. 87: Robert JY, Bretagne JF, Raoul JL, Siproudhis L, Heresbach D, Gosselin M. Recurrent cholangitis caused by the migration of pancreatic calculi associated with pancreas divisum. Gastrointest Endosc. 1993 May-Jun;39(3):452-4. PubMed PMID: 8514086. 88: Siproudhis L, Ropert A, Vilotte J, Bretagne JF, Heresbach D, Raoul JL, Gosselin M. How accurate is clinical examination in diagnosing and quantifying pelvirectal disorders? A prospective study in a group of 50 patients complaining of defecatory difficulties. Dis Colon Rectum. 1993 May;36(5):430-8. PubMed PMID: 8482161. 89: Raoul JL, Duvauferrier R, Bretagne JF, Bourguet P, Heresbach D, Siproudhis L, Gosselin M. Usefulness of hepatic artery injection of iodized oil and 131I-labeled iodized oil before the therapeutic decision in hepatocellular carcinoma. Scand J Gastroenterol. 1993 Mar;28(3):217-23. PubMed PMID: 7680489. 90: Siproudhis L, Le Gall R, Ropert A, Reignier A, Heresbach D, Raoul JL, Renet C, Bretagne JF, Gosselin M. [Does manometric megarectum have a symptomatic role in patients complaining of dyschezia?]. Gastroenterol Clin Biol. 1993;17(3):162-7. French. PubMed PMID: 8330689. 91: Bretagne JF, Guyader D, Darnault P, Raoul JL, Siproudhis L, De Malézieu N, Gosselin M. Relationship between gastric mucosal changes and hemodynamic patterns in alcoholic cirrhosis. A prospective study. Gastroenterol Clin Biol. 1993;17(10):636-42. PubMed PMID: 8288075. 92: Robert JY, Bretagne JF, Darnault P, Raoul JL, Siproudhis L, Heresbach D, Gosselin M. [Endoscopic treatment and extracorporeal lithotripsy in chronic calcifying pancreatitis. Preliminary results in 16 patients]. Gastroenterol Clin Biol. 1993;17(11):797-803. Review. French. PubMed PMID: 8143944. 93: Heresbach D, Robert I, Le Berre N, Raoul JL, Siproudhis L, Bretagne JF, Ramée MP, Gosselin M. [Cystic tumors and endocrine tumor of the pancreas. An unusual association]. Gastroenterol Clin Biol. 1993;17(12):968-71. French. PubMed PMID: 8125232. 94: Heresbach D, Raoul JL, Bretagne JF, Minet J, Donnio PY, Ramée MP, Siproudhis L, Gosselin M. Helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy. Gut. 1992 Dec;33(12):1608-11. PubMed PMID: 1487160; PubMed Central PMCID: PMC1379569. 95: Siproudhis L, Renet C, Bretagne JF, Raoul JL, Heresbach D, Gosselin M. Bleeding anal varix: adverse effects of local treatment with histoacryl. Am J Gastroenterol. 1992 Dec;87(12):1886-7. PubMed PMID: 1449166. 96: Raoul JL, Bretagne JF, Siproudhis L, Heresbach D, Campion JP, Gosselin M. Cystic duct clip migration into the common bile duct: a complication of laparoscopic cholecystectomy treated by endoscopic biliary sphincterotomy. Gastrointest Endosc. 1992 Sep-Oct;38(5):608-11. PubMed PMID: 1397923. 97: Raoul JL, Bretagne JF, Ropert A, Siproudhis L, Heresbach D, Gosselin M. Zollinger-Ellison syndrome, antisecretory treatment, and body weight. Dig Dis Sci. 1992 Aug;37(8):1308-9. PubMed PMID: 1354155. 98: Siproudhis L, Ropert A, Lucas J, Raoul JL, Heresbach D, Bretagne JF, Gosselin M. Defecatory disorders, anorectal and pelvic floor dysfunction: a polygamy? Radiologic and manometric studies in 41 patients. Int J Colorectal Dis. 1992 Jun;7(2):102-7. PubMed PMID: 1613294. 99: Heresbach D, Bretagne JF, Raoul JL, Siproudhis L, Campion JP, Launois B, Gosselin M. [Results of portacaval shunt after failure of sclerotherapy in patients with cirrhosis]. Ann Chir. 1992;46(5):411-6. French. PubMed PMID: 1416751. 100: Heresbach D, Raoul JL, Robert I, Zachar D, Siproudhis L, Le Berre N, Ramée MP, Bretagne JF, Gosselin M. [Villous tumors of the Wirsung's duct and pancreatic intraductal adenocarcinoma: interrelation or accidental association?]. Gastroenterol Clin Biol. 1992;16(12):999- 1005. Review. French. PubMed PMID: 1362960. 101: Raoul JL, Siproudhis L, Ropert A, Bretagne JF, Gosselin M. Gastric ulcer and cholestasis following injection therapy of bleeding duodenal ulcers. Endoscopy. 1991 Nov;23(6):351-2. PubMed PMID: 1778146. 102: Robert JY, Raoul JL, Bretagne JF, Denjean P, Heresbach D, Siproudhis L, Gosselin M. Unusual presentation of a case of brain abscess after endoscopic injection sclerotherapy of esophageal varices. Endoscopy. 1991 Jul;23(4):237-8. PubMed PMID: 1915144. 103: Siproudhis L, Beaugrand M, Malledant Y, Brissot P, Guguen-Guillouzo C, Guillouzo A. Use of adult human hepatocytes in primary culture for the study of clometacin-induced immunoallergic hepatitis. Toxicol In Vitro. 1991;5(5-6):529-34. PubMed PMID: 20732071. 104: Siproudhis L, Vilotte J, Bonfils S, Mignon M. [Idiopathic ulcerative proctitis. Clinical presentation and endoscopic outcome]. Gastroenterol Clin Biol. 1991;15(4):315-21. Review. French. PubMed PMID: 2060743. 105: Heresbach D, Ropert A, Raoul JL, Siproudhis L, Ramée MP, Bretagne JF, Gosselin M. [Gastroduodenal duplication and chronic hepatitis: fortuitous association?]. Gastroenterol Clin Biol. 1991;15(10):766-70. French. PubMed PMID: 1816017. 106: Raoul JL, Emery P, Bretagne JF, Chaperon J, Bansard JY, Siproudhis L, Gosselin M. [Digestive hemorrhage following gastroduodenal ulcers caused by non-steroidal anti-inflammatory agents]. Gastroenterol Clin Biol. 1991;15(12):950-5. French. PubMed PMID: 1783251. 107: Heresbach D, Bretagne JF, Raoul JL, Chaperon J, Piette C, Siproudhis L, Gastard J, Gosselin M. [Prognosis and prognostic factors of hemorrhage by rupture of varices in cirrhotic patients in the era of endoscopic sclerotherapy]. Gastroenterol Clin Biol. 1991;15(11):838-44. Review. French. PubMed PMID: 1769474. 108: Siproudhis L, Lescouarc'h J, Bretagne JF, Bourguet P, Raoul JL, Etienne PL, Herry JY, Gosselin M. [Contribution of 131I MIBG scintigraphy in the diagnosis of carcinoid tumors of the digestive tract. Experience of 14 cases]. Gastroenterol Clin Biol. 1991;15(11):789-93. French. PubMed PMID: 1769467. 109: Bretagne JF, Raoul JL, Siproudhis L, Cado JP, Gosselin M. [Successful treatment of fulminant Crohn's colitis with azathioprine]. Gastroenterol Clin Biol. 1991;15(8-9):654-5. French. PubMed PMID: 1752377. 110: Mallédant Y, Siproudhis L, Tanguy M, Clerc C, Chesné C, Saint-Marc C, Guillouzo A. Effects of halothane on human and rat hepatocyte cultures. Anesthesiology. 1990 Mar;72(3):526-34. PubMed PMID: 2310035. 111: Vilotte J, Siproudhis L, Leblanc S, Santa-Coloma M, Saleh T, Benhamou G, Chevalier T, Bonfils S, Mignon M. [Does retraining by biofeedback have a role in the treatment of solitary ulcer syndrome of the rectum?]. Gastroenterol Clin Biol. 1990;14(4):405-6. French. PubMed PMID: 2351250. 112: Siproudhis L, Bretagne JF, Raoul JL, Cottereau J, Gosselin M. [Gastric and duodenal metastases of esophageal cancer]. Gastroenterol Clin Biol. 1990;14(11):888-9. French. PubMed PMID: 2276572. 113: Bretagne JF, Raoul JL, Siproudhis L, Gosselin M. [Diagnosis of lesions in upper digestive hemorrhage related to portal hypertension]. Gastroenterol Clin Biol. 1990;14(1 ( Pt 2)):12B-20B. Review. French. PubMed PMID: 2179015. 114: Siproudhis L, Bretagne JF, Nicol L, Lebodic MF, Bourguet P, Kernec J, Lancien G, Herry JY, Gastard J. [Iodine-131 metaiodobenzylguanidine and carcinoid tumors]. Gastroenterol Clin Biol. 1987 Aug-Sep;11(8-9):612-4. French. PubMed PMID: 3653624. 115: Thomas R, Siproudhis L, Laurent JF, Bouget J, Bousser J, Camus C, Michelet C. Massive hemoptysis from iatrogenic balloon catheter rupture of pulmonary artery: successful early management by balloon tamponade. Crit Care Med. 1987 Mar;15(3):272-3. PubMed PMID: 2949940.