Substance: Fenbutrazate Based on the Current

Health Canada Santé Canada

STATUS DECISION OF CONTROLLED AND NON-CONTROLLED SUBSTANCE(S)

Based on the current information available to the Office of Controlled Substances, it appears that the above substance is:

Controlled ☐ Not Controlled X

under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following reason(s):

 The substance is related to phenmetrazine but is not captured under item 6 of Schedule IV to the CDSA.

Prepared by: ______Date: ______Vincent Marleau

Verified by: ______Date: ______Mark Kozlowski

Approved by: ______Date: ______DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES

This status was requested by: Dominique Franco, OCS

2 Drug Status Report

Drug: Fenbutrazate

Drug Name Status: Fenbutrazate is the common name.

Chemical Name: 2-(3-Methyl-2-phenylmorpholino)ethyl 2-phenylbutanoate

Other Names: Phenbutrazate; 2-Phenylbutyric Acid 2-(3-Methyl-2-phenylmorpholino)ethyl Ester; Fenbutrazatum; Nethanol; Phenbutrazatum; α-Ethylbenzeneacetic Acid 2-(3-Methyl-2- phenyl-4-morpholinyl)ethyl Ester.

Chemical structure:

Fenbutrazate Phenmetrazine

Molecular Formula: C23H29NO3 CAS-RN: 4378-36-3

Pharmacological class / Application: Phenmetrazine derivative

International status: US: Fenbutrazate is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website.

United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic Substances under International Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances under International Control.

Canadian Status: Fenbutrazate is not listed in the Schedules to the CDSA. The substance is related to phenmetrazine, which is currently listed as item 6 of Schedule IV to the CDSA under the heading “Phenmetrazine (3–methyl–2–phenylmorpholine) and any salt thereof”. However, given that fenbutrazate is not a salt of phenmetrazine, it is not captured under item 6 of Schedule IV to the CDSA.

Recommendation: Fenbutrazate is not included in the schedules to the CDSA and is not a controlled substance.

Date: July 17th, 2013.