Generated by SRI International Pathway Tools Version 25.0, Authors M

Bacillus subtilis subtilis 168 Chromosome

by Ingrid Keseler1, Ron Caspi1, Markus Krummenacker1, Pallavi Subhraveti1, Anamika Kothari1, Carol A Fulcher1, Amanda Mackie2 --- 1SRI International, 2Macquarie University Legend: Protein gene Transcription Start Adjacent genes drawn in the same color are within the same operon.

Copyright SRI International 2009-2021. All Rights Reserved. RNA gene Terminator Uncolored genes are not yet assigned to an operon. This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors M. Krummenacker and P.D. Karp. Pseudo-genes are crossed out with a big, diagonal X.

σA σA σA σA yaaAσA σA σA σE σA σE σA σF σW σA σK σA σG dnaA dnaN recF remB gyrB gyrA rrnO-16S rrnO-23S : ribosomal RNA-23S yaaC guaB dacA pdxS pdxT serS dck dgk yaaH yaaI tadA scr dnaX yaaK recR bofA rrnA-16S rrnA-23S : ribosomal RNA-23S xpaC yaaN yaaO tmk darA yaaR holB ricT yabA yabB yazA yabC abrB metS : methionyl-tRNA synthetase yabD yabE rnmV ksgA yabG veg ispE purR

2,000 4,000 6,000 8,000 10,000 12,000 14,000 16,000 18,000 20,000 22,000 24,000 26,000 28,000 30,000 32,000 34,000 36,000 38,000 40,000 42,000 44,000 46,000 48,000 50,000 52,000 54,000 σGF σB σH σA σG σA σA σA σA yazB σA σB purR yabJ spoVG gcaD prs ctc pth fin mfd : transcription-repair coupling factor spoVT yabM : putative exporter yabN rqcP yabP yabQ divIC yabR spoIIE yabS prkT tilS hprT ftsH coaX hslO yacD cysK pabB pabA pabC sul folB folK dusB lysS rrnJ-16S rrnJ-23S : ribosomal RNA-23S rrnW-16S rrnW-23S : ribosomal RNA-23S ctsR mcsA mcsB clpC radA disA yacL

56,000 58,000 60,000 62,000 64,000 66,000 68,000 70,000 72,000 74,000 76,000 78,000 80,000 82,000 84,000 86,000 88,000 90,000 92,000 94,000 96,000 98,000 100,000 102,000 104,000 106,000 108,000 σA σA secE σA σA rplGB rpmC rpsNA rpmD ybzG infA σG σG σE yacL ispD ispF gltX cysE cysS mrnC rlmB raeA sigH nusG rplK rplA rplJ rplL ybxB rpoB rpoC rpsL rpsG fusA : elongation factor G tufA ybaC rpsJ rplC rplD rplW rplB rpsS rplV rpsC rplP rpsQ rplNA rplX rplE rpsH rplF rplR rpsE rplO secY adk mapA rpsM rpsK rpoA rplQ ybxA ybaE ybaF truA rplM rpsI ybaJ ybaK cwlD salA gerD kbaA pdaB rrnI-16S rrnI-23S : ribosomal RNA-23S

110,000 112,000 114,000 116,000 118,000 120,000 122,000 124,000 126,000 128,000 130,000 132,000 134,000 136,000 138,000 140,000 142,000 144,000 146,000 148,000 150,000 152,000 154,000 156,000 158,000 160,000 162,000 164,000 σA σA σW σA σA σA rrnI-23S rrnH-16S rrnH-23S : ribosomal RNA-23S rrnG-16S rrnG-23S : ribosomal RNA-23S ybaR : putative permease ybaS ybbA feuC feuB feuA btr namZ nagZ : b-N-acetyl-glucosaminidase amiE murP ybbH murQ ybbJ ybbK sigW rsiW cdaA cdaR glmM glmS alkA adaA adaB ndhF ybcC ybcF ybcH ybcI ybzH ybcL ybcM skfB skfC skfE skfF

166,000 168,000 170,000 172,000 174,000 176,000 178,000 180,000 182,000 184,000 186,000 188,000 190,000 192,000 194,000 196,000 198,000 200,000 202,000 204,000 206,000 208,000 210,000 212,000 214,000 216,000 218,000 σAX σD σG σA σA σW σA σA σY σA σA skfG skfH ybdG ybdJ ybdK ybzI prkD ybdN ybdO ybxG csgA ybxI cypC ybyB aimA : H+/serine transporter glpQ glpT ybeF ybfA ybfB ybfE ybfF ybfG ybfH ybfI purT mpr ybfJ cesB pssA ybfM psd ybfN ybfO ybfP ybfQ gltP gamP gamA gamR ybgB ilvE ybgF ybgG glnT glsA glnJ glnL ycbC ycbD gudP gudD ycbG

220,000 222,000 224,000 226,000 228,000 230,000 232,000 234,000 236,000 238,000 240,000 242,000 244,000 246,000 248,000 250,000 252,000 254,000 256,000 258,000 260,000 262,000 264,000 266,000 268,000 270,000 272,000 σA σA ycbG σA rtpA σE σA tatAD σA σA σA σW σA σA σA garD ycbJ tboW ycbK ycbL ycbM ycbN ycbO ycbP cwlJ ycbR phoD tatCD pcp ycbU lmrB lmrA ansZ lip yczC yccF natK natR natA natB yccK ycdA ycdB ycdC cwlK rapJ ycdF ycdG znuA znuC znuB yceB yceC yceD yceE yceF yceG yceH niaP yceJ yceK opuAA opuAB opuAC amhX ycgA ycgB amyE

274,000 276,000 278,000 280,000 282,000 284,000 286,000 288,000 290,000 292,000 294,000 296,000 298,000 300,000 302,000 304,000 306,000 308,000 310,000 312,000 314,000 316,000 318,000 320,000 322,000 324,000 326,000 328,000 σA σA σE σB σA σA σA yczLσA σG σD σA amyE ldh lctP : L-lactate permease mdr ycgE ycgF ycgG ycgH ycgI nadE tmrB aroK ycgJ ycgK cah ycgL putB putC putP putR ycgQ ycgR ycgS ycgT nasF nasE nasD nasC nasB nasA folEB yciB zagA yckA yckB yckC yckD bglC nin nucA tlpC hxlB hxlA hxlR srfAA : surfactin synthetase

330,000 332,000 334,000 336,000 338,000 340,000 342,000 344,000 346,000 348,000 350,000 352,000 354,000 356,000 358,000 360,000 362,000 364,000 366,000 368,000 370,000 372,000 374,000 376,000 378,000 380,000 382,000 sfp bsdD σA σG σG σA σA srfAA : surfactin synthetase srfAB : surfactin synthetase srfAC : surfactin synthetase srfAD ycxA ycxB ycxC ycxD yczE tcyC tcyB tcyA yclA ubiX ubiD yclD yclE dtpT yclG : putative uronase gerKA gerKC gerKB yclH yclI yclJ yclK rapC thrD fpiB fpiC fpiD fpiA ycnB ycnC

384,000 386,000 388,000 390,000 392,000 394,000 396,000 398,000 400,000 402,000 404,000 406,000 408,000 410,000 412,000 414,000 416,000 418,000 420,000 422,000 424,000 426,000 428,000 430,000 432,000 434,000 436,000 σA σA σG yczO σK σB σM σA swaO σB ycnC ycnD ycnE yczG gabR gabT gabD glcU gdh ycnI ycnJ ycnK ycnL mtlA mtlF mtlD ycsA sipU yczH ycsD ycsE pxpA ycsG ycsI pxpB pxpC pxpR lipC yczI yczJ pbpC ycsN mtlR ydaB ydaC ydaD ydaE ydaF ydaG bsrC amj ydzA lrpC topB : DNA topoisomerase III ydaJ ydaK ydaL ydaM ydaN kimA : K+ importer mutT ydaP ydzK mntH

438,000 440,000 442,000 444,000 446,000 448,000 450,000 452,000 454,000 456,000 458,000 460,000 462,000 464,000 466,000 468,000 470,000 472,000 474,000 476,000 478,000 480,000 482,000 484,000 486,000 488,000 490,000 492,000 σBI ydaS σB σB σW σE σE σA σB conD rapI ydaT ydbA gsiB ydbB ydbC ydbD dctB dctS dctR dctP ydbI ydbJ ydbK ydbL ydbM ydbO ydbP ddl murF cshA ydbS ydbT ydcA acpS ssdC alrA ndoA rsbRA rsbS rsbT rsbU rsbV rsbW sigB rsbX ydcF ydcG pamR ydcI ydcK int immA immR xis ydzL devI helP conQ nicK ydcS ydcT yddA conB conC conE yddF conG : ICEBs1 conjugation machinery cwlT yddI yddJ yddK

494,000 496,000 498,000 500,000 502,000 504,000 506,000 508,000 510,000 512,000 514,000 516,000 518,000 520,000 522,000 524,000 526,000 528,000 530,000 532,000 534,000 536,000 538,000 540,000 542,000 544,000 546,000 ydzM ydzN cspC ydzE ydzO ydzPydzQ σA σA σA σB ydzH σG σG rapI yddM yddN lrpA lrpB yddQ yddR yddS yddT ydeA cdnL ydeC ydeD ydeE ydeF ydeG ydeH ydeI ydeJ ydeK ydeL ydeM ydeN ydzF ydeO ydeP ydeQ ydeR ydeS aseR ydfA ydfB ydfC ydfD ydfE ydfF ydfG ydfH ydfI ydfJ nap ydfK ydfL mneP ydfN ydfO ydfP ydfQ ydfR ydfS cotP

548,000 550,000 552,000 554,000 556,000 558,000 560,000 562,000 564,000 566,000 568,000 570,000 572,000 574,000 576,000 578,000 580,000 582,000 584,000 586,000 588,000 590,000 592,000 594,000 596,000 598,000 600,000 602,000 σE σK σE σA σA σB σA tatAY ydiK groESσA ydzT ydzT ydzT ydzV ydgB ydgC ydgD ydgE vmlR ydgF bstG ydgG ydgH : putative membrane component ydgI ydgJ ydgK ydhB ydhC ydhD ydhE ydhF phoB fra ydhH ydhI ydhJ copL pbuE A gmuB gmuA gmuC gmuD gmuR gmuE gmuF gmuG rrnE-16S rrnE-23S : ribosomal RNA-23S thiL tsaE tsaB rimI tsaD ydiF moaC rex tatCY ydiL groEL ydiM ydzU ydiO ydiP

604,000 606,000 608,000 610,000 612,000 614,000 616,000 618,000 620,000 622,000 624,000 626,000 628,000 630,000 632,000 634,000 636,000 638,000 640,000 642,000 644,000 646,000 648,000 650,000 652,000 654,000 656,000 σA ydzW ydzW ydzW σA σW σA ydzJ ydjO σW σK σA σA yebD σA ydiP ydiR ydiS ydjA ydjB ydjC gutR gutB gutP ydjE pspA ydjG ydjH ydjI ydjJ iolT bdhA ydjM ydjN ydjP yeaA cotA gabP ydzX mneS yeaC yeaD yebA : conserved hypothetical protein guaA : GMP synthetase pbuG yebC yebE purE purK purB purC purS purQ purL purF purM purN purH purD yezC

658,000 660,000 662,000 664,000 666,000 668,000 670,000 672,000 674,000 676,000 678,000 680,000 682,000 684,000 686,000 688,000 690,000 692,000 694,000 696,000 698,000 700,000 702,000 704,000 706,000 708,000 710,000 σB yezF σA yezA σA σA cotJAσE cotJB yecA yerA yerB yerC yerD pcrB pcrA : ATP-dependent DNA helicase ligA : DNA ligase (NAD-dependent) yerH yerI sapB opuE gatC gatA gatB yerO swrC dgkB rlmCD yefB yefC dnmA : DNA methyltransferase yeeB yeeC yeeD yezG yeeF yeeG rapH yeeI yeeK yezE yesE yesF cotJC yesJ yesK yesL yesM yesN yesO yesP yesQ yesR yesS

712,000 714,000 716,000 718,000 720,000 722,000 724,000 726,000 728,000 730,000 732,000 734,000 736,000 738,000 740,000 742,000 744,000 746,000 748,000 750,000 752,000 754,000 756,000 758,000 760,000 762,000 764,000 766,000 σA yetI yetI yezD σK σD σA yesS rhgT yesU yesV yesW yesX : polysaccharide lyase yesY rhgZ : beta-galacturonidase yetA : putative enzyme lplA lplB lplC lplD yetF hmoA yetH yetJ yetK yetL yetM yetN yetO : bifunctional P-450/NADPH-P450 reductase 1 ltaSA spsN spsO spsP spsQ spsR yfnC yfnB yfnA yfmT yfmS yfmR yfmQ yfmP yfmO yfmM yfmL yfmK yfmJ yfmI yfmG

768,000 770,000 772,000 774,000 776,000 778,000 780,000 782,000 784,000 786,000 788,000 790,000 792,000 794,000 796,000 798,000 800,000 802,000 804,000 806,000 808,000 810,000 812,000 814,000 816,000 818,000 820,000 σA σA σA σA σB yfkS σA σB σG yfmG yfmF yfmE yfmD yfmC yfmB yflT pel : pectate lyase yflS citS citT yflP citM yflN nosA yflL yflK yflH mapB nagP ltaSB yflB yflA yfkT yfkR yfkQ treP treA treR hypO yfkN yfkM yfkL yfkJ yfkI yfkH yfkF chaA yfkD yfkC yfkA pdaA yfjR yfjQ yfjP yfjO yfzA

822,000 824,000 826,000 828,000 830,000 832,000 834,000 836,000 838,000 840,000 842,000 844,000 846,000 848,000 850,000 852,000 854,000 856,000 858,000 860,000 862,000 864,000 866,000 868,000 870,000 872,000 874,000 σL σA yfhD σG σB dusC yfjM yfjL acoA acoB acoC acoL acoR yfjF yfjE yfjD yfjC yfjB yfjA malA malR malP yfiB yfiC catD catE yfiF yfiG yfiH yfiI lnrJ lnrK lnrL lnrM lnrN padR estB yfiQ yfiR yfiS bstA yfiU yfiV mprF yfiY yfiZ yfhA yfhB yfhC yfhF recX yfhH yfhI yfhJ yfhK yfhL yfhM

876,000 878,000 880,000 882,000 884,000 886,000 888,000 890,000 892,000 894,000 896,000 898,000 900,000 902,000 904,000 906,000 908,000 910,000 912,000 914,000 916,000 918,000 920,000 922,000 924,000 926,000 928,000 930,000 σX σA σB σK σE σA σA σH ygzA σA σA ygzD σE σE yhcD σA csbB yfhO yfhP mutY fabL sspE ygaB ygaC ygaD ygaE gsaB ygaF perR ygzB ygxA rrnD-16S rrnD-23S : ribosomal RNA-23S spo0M ygzC ygaJ thiC ygaK katA ssuB ssuA ssuC ssuD ygaN ygaO yhzB queG yhbB cspR yhbD yhbE yhbF prkA yhbH yhbI yhbJ yhcA yhcB yhcC yhcE yhcF yhcG yhcH yhcI yhcJ

932,000 934,000 936,000 938,000 940,000 942,000 944,000 946,000 948,000 950,000 952,000 954,000 956,000 958,000 960,000 962,000 964,000 σA 966,000 968,000 970,000 972,000 974,000 976,000 978,000 980,000 982,000 984,000 σFG σEK σI σA σA σF σG σG yhzG σA σA σA σD σE σA σH σA σA σB σM σB yhcJ dgcK tcyP yhcM yhcN yhcO yhcQ yhcR srtA yhcT yhcU yhcV yhcW yhcX yhxA glpP glpF glpK glpD pgcA yhcY yhcZ yhdA yhdB yhdC lytF nsrR ygxB spoVR phoA lytE citR citA yhdF bcaP yhdH yhdI yhdJ yhdK yhdL sigM yhdN plsC yhdP cueR pheC yhdT fluC yhdV yhdW yhdY

986,000 988,000 990,000 992,000 994,000 996,000 998,000 1,000,000 1,002,000 1,004,000 1,006,000 1,008,000 1,010,000 1,012,000 1,014,000 1,016,000 1,018,000 1,020,000 1,022,000 1,024,000 1,026,000 1,028,000 1,030,000 1,032,000 1,034,000 1,036,000 1,038,000 1,040,000 σB σG σE σA σE σA yhzD yhaL σK σK σA σA σA srtN yheN dat nhaC nhaX bmrC bmrD yheG yheD yheC yheB yheA yhaZ yhaX hemZ khtU khtT khtS yhaR yhaQ yhaP yhaO sbcE yhaM prsA yhaJ yhaI scoC yhaH trpP serC hinT ecsA ecsB ecsC sndC yhfA yhgB hmoB pbpF hemE hemH hemY yhgD yhgE : putative methyl-accepting protein fabHB yhfC

1,042,000 1,044,000 1,046,000 1,048,000 1,050,000 1,052,000 1,054,000 1,056,000 1,058,000 1,060,000 1,062,000 1,064,000 1,066,000 1,068,000 1,070,000 1,072,000 1,074,000 1,076,000 1,078,000 1,080,000 1,082,000 1,084,000 1,086,000 1,088,000 1,090,000 1,092,000 1,094,000 σA σK σA σF σA σD σF σE σA yhjC σE σA gerPF gerPD yhfE yhfF gltT yhfI lplJ yhfK lcfB yhfM yhfN aprE yhfO yhfP yhfQ phoE yhfS yhfT bioY hemAT yhfW yhxC comK yhxD yhjA yhjB yhjD yhjE sipV yhjG yhjH glcP ntdC ntdB ntdA ntdR yhjN yhjO yhjP yhjQ yhjR addB addA sbcD sbcC : DNA ATP-dependent repair enzyme hlpB gerPE gerPC

1,096,000 1,098,000 1,100,000 1,102,000 1,104,000 1,106,000 1,108,000 1,110,000 1,112,000 1,114,000 1,116,000 1,118,000 1,120,000 1,122,000 1,124,000 1,126,000 1,128,000 1,130,000 1,132,000 1,134,000 1,136,000 1,138,000 1,140,000 1,142,000 1,144,000 1,146,000 1,148,000 σEK gerPC σK σE σG σK σG yizC σA yisJ yisK yisL wprA : cell wall-associated protease yisN asnO bstH yisP yisQ yisR iolQ iolX bstC yisU yisV yisX yisY yisZ yitA yitB yitC yitD yitE yitF yitG yitH yitI yitJ yitK yitL yitM yitO yitP yizB yitQ yitR nprB yitS yitT ipi yitU yitV yitW yitY yitZ argC argJ argB argD carA carB argF

1,150,000 1,152,000σ 1,154,000 1,156,000 1,158,000 1,160,000 1,162,000 1,164,000 1,166,000 1,168,000 1,170,000 1,172,000 1,174,000 1,176,000 1,178,000 1,180,000 1,182,000 1,184,000 1,186,000 1,188,000 1,190,000 1,192,000 1,194,000 1,196,000 1,198,000 σ 1,200,000 1,202,000 1,204,000 A yjzK K yjzD σA appA appA tboWA σX σE σA σD thiS σI σE σK σK σE σK σK σA yjaU yjaV med yjzB fabHA fabF yjaZ appD appF appB appC yjbA trpS oppA oppB oppC oppD oppF yjbB yjbC spxA yjbE mecA coiA pepF : oligoendopeptidase F spxH yjbI cwlQ yjbK yjbL sasB nadF yjbO prpE cpaA : gated K+/H+ antiporter tenA tenI thiO thiG thiF thiD fabI cotO cotZ cotY cotX cotW cotV yjcA yjcB yjcD yjzE yjcF yjcG yjcH metI

1,206,000 1,208,000 1,210,000 1,212,000 1,214,000 1,216,000 1,218,000 1,220,000 1,222,000 1,224,000 1,226,000 1,228,000 1,230,000 1,232,000 1,234,000 1,236,000 1,238,000 1,240,000 1,242,000 1,244,000 1,246,000 1,248,000 1,250,000 1,252,000 1,254,000 1,256,000 1,258,000 yjzG σD σE yjzH σK σE σD σB yjzI σA σA metI metC yjcK yjcL yjcM yjcN yjcO yjcP yjcQ yjcR yjcS yjdA yjdB manR : transcription activator manP manA yjdF yjdG yjdH yjdI yjdJ ctaB1 cotT pdaC yjfA yjfC yjgA yjgB yjgC yjgD yjhA yjhB yjiA yjiB yjiC yjjA yjkA yjkB yjlA yjlB yjlC ndh uxaC exuM yjmC yjmD uxuA uxuB exuT exuR uxaB uxaA yjnA

1,260,000 1,262,000 1,264,000 1,266,000 1,268,000 1,270,000 1,272,000 1,274,000 1,276,000 1,278,000 1,280,000 1,282,000 1,284,000 1,286,000 1,288,000 1,290,000 1,292,000 1,294,000 1,296,000 1,298,000 1,300,000 1,302,000 1,304,000 1,306,000 1,308,000 1,310,000 1,312,000 σW σA xkdC ykzK ykzM xkzB xkdX σA σA σA σA bstD yjoB rapA yjpA xlyB yjqA pghB yjqC xkdA xre xkdB xkdD xpf xtmA xtmB xkdE xkdF xkdG ykzL xkdH xkdI xkdJ xkdK xkdM xkdN xkdO : phage PBSX; putative tape measure protein xkdP xkdQ xkdR xkdS xkdT xkdU xkzA xkdV xkdW xepA xhlA xhlB xlyA spoIISA pit ykaA steT mhqA ykcB ykcC htrA proG dppA dppB dppC dppD dppE ykfA ykfB ykfC

1,314,000 1,316,000 1,318,000 1,320,000 1,322,000 1,324,000 1,326,000 1,328,000 1,330,000 1,332,000 1,334,000 1,336,000 1,338,000 1,340,000 1,342,000 1,344,000 1,346,000 1,348,000 1,350,000 1,352,000 1,354,000 1,356,000 σ 1,358,000 1,360,000 1,362,000 1,364,000 1,366,000 1,368,000 σB σA ykzH σA σA σB σA mswB I σA σG ykzPykzE mtnK ykfD pgl ykgA ykhA hmp ykjA bstF ykkB gdnC gdnD purU proB proA ohrA ohrR ohrB guaD metE isp rsbRB thiX thiW thiV thiU ykoG ykoH ykoI ykoJ mgtE tnrA ykoM ykoN ykoP ykoQ ykoS ykoT ligD ligV dgcW : diguanylate cyclase ykoX ykoY sigI rsgI ykrK htpX ktrD ykrP kinE ogt mtnA

1,370,000 1,372,000 1,374,000 1,376,000 1,378,000 1,380,000 1,382,000 1,384,000 1,386,000 1,388,000 1,390,000 1,392,000 1,394,000 1,396,000 1,398,000 1,400,000 1,402,000 1,404,000 1,406,000 1,408,000 1,410,000 1,412,000 1,414,000 1,416,000 1,418,000 1,420,000 1,422,000 σA σA σA σA σA σA σA σD σA σE σK ykzQ ykvS σE σA σA splAσG σD σH σD σK fadHσA mtnK mtnU mtnE mtnW mtnX mtnB mtnD ykvA eag kinD mhqR motB motA clpE ykvI queC queD queE queF ykvN ykvO ykvP ykvQ ykzR ykvR ykvT ykvU stoA pfeT papB ykvZ glcT ptsG ptsH ptsI splB ykwB mcpC ohaC ykwD pbpH kinA patA cheV kre ykuC ldt ykuE

1,424,000 1,426,000 1,428,000 1,430,000 1,432,000 1,434,000 1,436,000 1,438,000 1,440,000 1,442,000 1,444,000 1,446,000 1,448,000 1,450,000 1,452,000 1,454,000 1,456,000 1,458,000 1,460,000 1,462,000 1,464,000 1,466,000 1,468,000 1,470,000 1,472,000 1,474,000 1,476,000 1,478,000 σA σWX abbA σI σE σW σI σA σA σA fadH fadG ykzU ykuH ykuI ykuJ ykuK darB ccpC ykuN ykuO ykuP dapH dapI ykuS ykuT ahpA ahpT rok yknT mobA moeB moeA mobB moaE moaD yknU yknV yknW yknX yknY yknZ fruR fruK fruA sipT ykoA ykpA panE ampS : aminopeptidase mreBH abh kinC ykqA ktrC adeC : adenine deaminase rnjA ykrA defB ykzV ykyA pdhA pdhB pdhC pdhD

1,480,000 1,482,000 1,484,000 1,486,000 1,488,000 1,490,000 1,492,000 1,494,000 1,496,000 1,498,000 1,500,000 1,502,000 1,504,000 1,506,000 1,508,000 1,510,000 1,512,000 1,514,000 1,516,000 1,518,000 1,520,000 1,522,000 1,524,000 1,526,000 1,528,000 1,530,000 1,532,000 σA ykzI σA ylaF σG σE σF σK σE ylzH σE σA σA σE pdhD slp srrA speA yktA yktB suhB ykzC yktD nprE ylaA ylaB ylaC ylaD ylaE bipA ylaH ylaJ ylaK ylaL glsB ylaN ftsW pycA : pyruvate carboxylase ctaA ctaB ctaC ctaD ctaE ctaF ctaG ylbA ylbB ylbC ylbD ylbE ricF ylbG ylbH coaD spoVV ylbK ylbL tmcAL ylbN gerR ylbP ylbQ bshC mraZ rsmH ftsL pbpB : penicillin-binding protein 2B spoVD murE

1,534,000 1,536,000 1,538,000 1,540,000 1,542,000 1,544,000 1,546,000 1,548,000 1,550,000 1,552,000 1,554,000 1,556,000 1,558,000 1,560,000 1,562,000 1,564,000 1,566,000 1,568,000 1,570,000 1,572,000 1,574,000 1,576,000 1,578,000 1,580,000 1,582,000 1,584,000 1,586,000 σA σH σA σA σA σA σE mraY murD spoVE murG murB divIB ylxW ylxX sbp ftsA ftsZ bpr : bacillopeptidase F spoIIGA sigE sigG ylmA thiQ ylmC ylmD ylmE sepF ylmG ylmH divIVA ileS : isoleucyl-tRNA synthetase ylyA lspA rluD pyrR pyrP : uracil permease pyrB pyrC : dihydroorotase pyrAA pyrAB pyrK pyrD pyrF pyrE cysH cysP sat cysC sumT sirB sirC rqcH yloB yloC remA gmk

1,588,000 1,590,000 1,592,000 1,594,000 1,596,000 1,598,000 1,600,000 1,602,000 1,604,000 1,606,000 1,608,000 1,610,000 1,612,000 1,614,000 1,616,000 1,618,000 1,620,000 1,622,000 1,624,000 1,626,000 1,628,000 1,630,000 1,632,000 1,634,000 1,636,000 1,638,000 1,640,000 1,642,000 rpoZ σErpmB σA σA σD σA σA σD σA coaBC priA defA fmt rsmB rlmN prpC prkC cpgA rpe thiN yloU yloV sdaAB sdaAA recG fapR plsX fabD fabG rnc smc : chromosome condensation and segregation SMC ATPase ftsY sivC ylxM ffh rpsP ylqC ylqD rimM trmD rplS rbgA rnhB ylqG ylqH sucC sucD dprA topA : DNA topoisomerase I trmFO codV clpQ clpY codY flgB flgC fliE fliF fliG fliH fliI

1,644,000 1,646,000 1,648,000 1,650,000 1,652,000 1,654,000 1,656,000 1,658,000 1,660,000 1,662,000 1,664,000 1,666,000 1,668,000 1,670,000 1,672,000 1,674,000 1,676,000 1,678,000 1,680,000 1,682,000 1,684,000 1,686,000 1,688,000 1,690,000 1,692,000 1,694,000 1,696,000 swrD surG σK σA fliJ ylxF fliK flgD flgE fliL fliM fliY cheY fliZ fliP fliQ fliR flhB flhA flhF flhG cheB cheA cheW cheC cheD sigD swrB rpsB tsf pyrH frr uppS cdsA dxr rasP proS : prolyl-tRNA synthetase polC : DNA polymerase III (alpha subunit), subunit of DNA polymerase III ylxS nusA ylxR rplGA infB : initiation factor IF-2 ylxP rbfA truB ribC rpsO pnpA swsB mlpA ymxH spoVFA spoVFB asd dapG dapA rnjB tepA

1,698,000 1,700,000 1,702,000 1,704,000 1,706,000 1,708,000 1,710,000 1,712,000 1,714,000 1,716,000 1,718,000 1,720,000 1,722,000 1,724,000 1,726,000 1,728,000 1,730,000 1,732,000 1,734,000 1,736,000 1,738,000 1,740,000 1,742,000 1,744,000 1,746,000 1,748,000 1,750,000 σWX σE σA ymfK σA σH σK surX spoIIIE ymfC ymfD ymfF ymfH efpI ymfJ rodZ pgsA cinA recA pbpX rny : endoribonuclease Y pdeB tdh kbl ymcB ricA cotE mutS mutL ymzD ymcC pksA pksB pksC pksD pksE acpK pksF pksG pksH pksI pksJ : polyketide synthase of type I involved in nonribosomal synthesis of bacillaene

1,752,000 1,754,000 1,756,000 1,758,000 1,760,000 1,762,000 1,764,000 1,766,000 1,768,000 1,770,000 1,772,000 1,774,000 1,776,000 1,778,000 1,780,000 1,782,000 1,784,000 1,786,000 1,788,000 1,790,000 1,792,000 1,794,000 1,796,000 1,798,000 1,800,000 1,802,000 1,804,000 1,806,000

pksJ pksL : polyketide synthase of type I (bacillaene synthesis) pksM : trans AT polyketide synthase of type I involved in bacillaene synthesis pksN : trans AT polyketide synthase of type I involved in bacillaene synthesis pksR : trans AT polyketide synthase involved in nonribosomal synthesis of bacillaene pksS ymzB ymaE

1,808,000 1,810,000 1,812,000 1,814,000 1,816,000 1,818,000 1,820,000 1,822,000 1,824,000 1,826,000 1,828,000 1,830,000 1,832,000 1,834,000 1,836,000 1,838,000 1,840,000 1,842,000 1,844,000 1,846,000 1,848,000 1,850,000 1,852,000 1,854,000 1,856,000 1,858,000 1,860,000 σE σA ymzE σK σA σK σK σA ynzI σA σA σE BSU_17689 σK σE σG σK yndM aprX pghC ymaD ebrB ebrA ymaG ymaF miaA hfq ymzC nrdI nrdE nrdF ymaB cwlC spoVK ynbA ynbB glnR glnA ynxB ynzF ynzG ynaB ynaC ynaD ynaE ynaF ynaG ynaI xynP xynB xylR xylA : xylose isomerase xylB : xylulose kinase yncB yncC alrB yncE yncF cotU thyA yncM ynzK yndA yndB yndD yndE yndF yndG yndH yndJ yndK surA pghL

1,862,000 1,864,000 1,866,000 1,868,000 1,870,000 1,872,000 1,874,000 1,876,000 1,878,000 1,880,000 1,882,000 1,884,000 1,886,000 1,888,000 1,890,000 1,892,000 1,894,000 1,896,000 1,898,000 1,900,000 1,902,000 1,904,000 1,906,000 1,908,000 1,910,000 1,912,000 1,914,000 1,916,000 σFG σW yzzP σA σK σG σA ynfCc σA yngHB σE σK yndM fosB lexA yneA yneB tkt : transketolase sirA ccdA yneI yneJ yneK cotM citB yneN tlp yneP yneQ yneR plsY yneT parE parC ynfC alsT eglS ynfE xynC xynD yngA yngB yngC nrnB yngE yngF yngG yngHA yngI yngJ ynzE yngK yngL ppsE : nonribosomal plipastatin synthetase E ppsD : nonribosomal plipastatin synthetase D involved in synthesis of plipastatin

1,918,000 1,920,000 1,922,000 1,924,000 1,926,000 1,928,000 1,930,000 1,932,000 1,934,000 1,936,000 1,938,000 1,940,000 1,942,000 1,944,000 1,946,000 1,948,000 1,950,000 1,952,000 1,954,000 1,956,000 1,958,000 1,960,000 1,962,000 1,964,000 1,966,000 1,968,000 1,970,000 σBH yoeD σA σA σA σB ppsD ppsC : non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin ppsB : nonribosomal plipastatin synthetase B involved in synthesis of plipastatin ppsA : non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin dacC galM yoeA iseA yoeC ggt ftsR yogA gltB gltA gltC proJ proH rtp yoxD yoxC yoxB yoaA yoaB yoaC yoaD yoaE

1,972,000 1,974,000 1,976,000 1,978,000 1,980,000 1,982,000 1,984,000 1,986,000 1,988,000 1,990,000 1,992,000 1,994,000 1,996,000 1,998,000 2,000,000 2,002,000 2,004,000 2,006,000 2,008,000 2,010,000 2,012,000 2,014,000 2,016,000 2,018,000 2,020,000 2,022,000 2,024,000 σW σW σG σD σK σG σE yozU σA yozW yozX yozZ yoyA σW yoaE yoaF yoaG yozQ yoaH yoaI exlX yoaK pelB yoaM yozS oxdD yoaO yoaP yoaQ yozT yozF yoaR yoaS yozG yoaT yoaU cyeA yoaW yoaZ penP yobA yobB pps : putative PEP-dependent enzyme xynA yozV yobD yozH yozI yobE yobF yozJ yozY rapK yobH yozK yozL yozM yobI asrE yobJ rttM rttL yobM yobN yobO csaA yobQ

2,026,000 2,028,000 2,030,000 2,032,000 2,034,000 2,036,000 2,038,000 2,040,000 2,042,000 2,044,000 2,046,000 2,048,000 2,050,000 2,052,000 2,054,000 2,056,000 2,058,000 2,060,000 2,062,000 2,064,000 2,066,000 2,068,000 2,070,000 2,072,000 2,074,000 2,076,000 2,078,000 2,080,000 σK σA σA σA σB yoyB σW yozC σA σA σA σK σA σK yobR yobS yobT yobU yobV yobW czrA yocA ctaM yocB yocC yocD des desK desR yocH rtbI : ATP-dependent helicase rtbJ yocK yocL yocM yozN yocN yozO dhaS sqhC sodF yocR yocS odhB odhA : 2-oxoglutarate dehydrogenase (E1 subunit) yojO yojN sodC cwlS yojK cdaS norM rsbRC bshB2 yojF yoyC yojE gerT yojB yojA yodA yodB yodC yodD yodE yodF ctpA yodH yodI ldcB

2,082,000 2,084,000 2,086,000 2,088,000 2,090,000 2,092,000 2,094,000 2,096,000 2,098,000 2,100,000 2,102,000 2,104,000 2,106,000 2,108,000 2,110,000 2,112,000 2,114,000 2,116,000 2,118,000 2,120,000 2,122,000 2,124,000 2,126,000 2,128,000 2,130,000 2,132,000 2,134,000 ldcB yozD yoyF yozE yoyG σK σK yodU sprB σB yotJ yotH yotC σG yojW yosQ srdEi yosK yosJ yosB yorZ yorY yorX yorV yorQ yorP yorO yorN deoD yodL yodM yodN yokU kamA yodP yodQ yodR yodS yodT cgeE cgeD cgeC cgeA cgeB phy : phytase yotM yotL yotI yotG yotB yosX yosW yosV yosU yosT yosS yosR nrdFB nrdFBsrdFi nrdFB nrdEB nrdEB nrdEB nrdIB yosL yosH yosG yosE yosD yosC yorW mtbP yorS yorR yorM yorL : DNA polymerase with 3'-5' exonuclease activity; phage SPbeta yorK yorJ yorI yorH yorG yorF yorE yorD yorC yorB yorA

2,136,000 2,138,000 2,140,000 2,142,000 2,144,000 2,146,000 2,148,000 2,150,000 2,152,000 2,154,000 2,156,000 2,158,000 2,160,000 2,162,000 2,164,000 2,166,000 2,168,000 2,170,000 2,172,000 2,174,000 2,176,000 2,178,000 2,180,000 2,182,000 2,184,000 2,186,000 2,188,000 yoqX yoqT yoqN yoqK yoqI yoqF yoqE yopZ yopV yopU yopT yopS yopO yopM yopF yoyH yoyI yopB yonU spbT yonP yonK yomT yomP pghZ yoqY yoqW ligB yoqU yoqS yoqR yoqP yoqO yoqM yoqL yoqJ yoqH yoqG yoqD yoqC yoqB yoqA yopY yopX yopW yopR yopQ yopP yopN aimX aimR yopJ yopI yopH yopE yopD yopC yopA yonX yonV yoyJ yonS yonR yonO yonN yonJ yonI yonH yonG yonF yonE yonD yonC yonB yonA yomZ yomY yomX yomW yomV yomU youA yomS yomR yomQ yomO

2,190,000 2,192,000 2,194,000 2,196,000 2,198,000 2,200,000 2,202,000 2,204,000 2,206,000 2,208,000 2,210,000 2,212,000 2,214,000 2,216,000 2,218,000 2,220,000 2,222,000 2,224,000 2,226,000 2,228,000 2,230,000 2,232,000 2,234,000 2,236,000 2,238,000 2,240,000 2,242,000 2,244,000 youB asrG yoyK ypmT yomN yomM yozP yomL yomK yomJ cwlP : lytic transglycosylase; SPbeta phage protein yomH yomG yomF yomE yomD blyA bhlB bdbB sunS bdbA sunT sunI uvrX yolD yolC yolB yolA yokL yokK yokJ yokI yokH yokG yokF yokE yokD yokC yokB sprA msrB msrA ypoP dinF ypmS ypmR scuA ypmP ilvA yplP yplQ ypkP dfrA thyB ypjQ ypjP

2,246,000 2,248,000 2,250,000 2,252,000 2,254,000 2,256,000 2,258,000 2,260,000 2,262,000 2,264,000 2,266,000 2,268,000 2,270,000 2,272,000 2,274,000 2,276,000 2,278,000 2,280,000 2,282,000 2,284,000 2,286,000 2,288,000 2,290,000 2,292,000 2,294,000 2,296,000 2,298,000 σEK σD σG ypeQ σG σG ypzF σA σA yptA ypzG σK σG ypiP brxA ilvD ypgR ypgQ bsaA metA ugtP ypzA ypeP ypdP ypdQ exoR ypbS dynA : dynamin GTPase bpsB bpsA pbuX xpt G ypwA kdgT kdgA kdgK kdgR kduI kduD ypvA ypsC rnpB gpsB ypsA mrfB mrfA : ATP-dependent helicase ptsA ypqA yppG yppE yppD yppC recU ponA ypoC nth dnaD asnS aspB tseB dinG panD panC panB

2,300,000 2,302,000 2,304,000 2,306,000 2,308,000 2,310,000 2,312,000 2,314,000 2,316,000 2,318,000 2,320,000 2,322,000 2,324,000 2,326,000 2,328,000 2,330,000 2,332,000 2,334,000 2,336,000 2,338,000 2,340,000 2,342,000 2,344,000 2,346,000 2,348,000 2,350,000 2,352,000 2,354,000 σE σA σE σA σA mtrB σA σH σA σE yphE ypzH σF ypfB σG σA panB birA cca bshA bshB1 mgsA dapB ypjD ypjC ypjB ypjA qcrC qcrB qcrA ypiF ypiB ypiA aroE tyrA hisC trpA trpB trpF trpC trpD trpE aroH aroB aroF cheR ndk hepT menH hepS folEA hbs spoIVA yphF gpsA engA seaA yphA fni ypfD cmk dgrA ypeB sleB prsW bdr gudB mecB ypbG ypbF ypbE ypbD recQ ypbB

2,356,000 2,358,000 2,360,000 2,362,000 2,364,000 2,366,000 2,368,000 2,370,000 2,372,000 2,374,000 2,376,000 2,378,000 2,380,000 2,382,000 2,384,000 2,386,000 2,388,000 2,390,000 2,392,000 2,394,000 2,396,000 2,398,000 2,400,000 2,402,000 2,404,000 2,406,000 2,408,000 σA σA σX σA σE ypuC σB σA spoVAEB σG spoIIAA σFG σA σA σE brfA σA yqkE ypbB fer fmnP fswB serA aroC rsiX sigX resE resD resC resB resA rluB spmB spmA dacB ypuI scpB scpA ypuF ypzK ribH ribA ribE ribD ypuD sipS ypzC ppiB ypuA lysA spoVAF spoVAEA spoVAD spoVAC spoVAB spoVAA sigF spoIIAB dacF pupG drm ripX fur spoIIM mleA mleN ansB ansA ansR yqxK nudF yqkF yqkD yqkC yqkB yqkA yqjZ

2,410,000 2,412,000 2,414,000 2,416,000 2,418,000 2,420,000 2,422,000 2,424,000 2,426,000 2,428,000 2,430,000 2,432,000 2,434,000 2,436,000 2,438,000 2,440,000 2,442,000 2,444,000 2,446,000 2,448,000 2,450,000 2,452,000 2,454,000 2,456,000 2,458,000 2,460,000 2,462,000 σWX yqzH yqjU σA σB σA σL σE σA yqjY yqjX polYB yqjV yqjT coaA dsdA yqjQ yqjP pswI proI yqjN : putative N-deacylase yqjM yqjL rnz zwf gndA polYA mifM yqjG yqjF yqjE yqjD yqjC yqjB yqjA artR artQ artP brxB bmrU bmr bmrR bkdB bkdAB bkdAA lpdV buk bcd ptb bkdR : transcriptional regulator mmgF prpD mmgD mmgC mmgB mmgA yqiK yqiI yqiH yqiG spo0A

2,464,000 2,466,000 2,468,000 2,470,000 2,472,000 2,474,000 2,476,000 2,478,000 2,480,000 2,482,000 2,484,000 2,486,000 2,488,000 2,490,000 2,492,000 2,494,000 2,496,000 2,498,000 2,500,000 2,502,000 2,504,000 2,506,000 2,508,000 2,510,000 2,512,000 2,514,000 2,516,000 2,518,000 σBF σA σH σA σFG spoIIIAD σE swgA σA σA σF σA σB σB σB yqgW yqgQ spo0A spoIVB recN ahrC yqxC dxs ispA xseB xseA folD nusB yqhY accC accB spoIIIAH spoIIIAG spoIIIAF spoIIIAE spoIIIAB spoIIIAA yqhV efp papA yqhS yqhR yqhQ yqhP yqhO mntR lipM yqhL gcvPB gcvPA gcvT yqhH yqhG sinR tasA sipW tapA yqzG comGG comGF comGE comGD comGC comGB comGA corA yqhB rsbRD mgsR yqgY yqgX yqgV yqgU yqgT ltaSC glcK glpG

2,520,000 2,522,000 2,524,000 2,526,000 2,528,000 2,530,000 2,532,000 2,534,000 2,536,000 2,538,000 2,540,000 2,542,000 2,544,000 2,546,000 2,548,000 2,550,000 2,552,000 2,554,000 2,556,000 2,558,000 2,560,000 2,562,000 2,564,000 2,566,000 2,568,000 2,570,000 2,572,000 σB glpG yqgO σA σE σG σK antEσA tboG σAB σE σW rpsU yqgN yqgM yqgL sweD sweC pstBB pstBA pstA pstC pstS pbpA yqgE sodA yqgC yqgB yqgA yqfZ ispG yqfX yqfW zur yqfU yqfT nfo cshB yqfQ ispH yqfO trmK cccA sigA dnaG : DNA primase yqxD yqfL ccpN glyS glyQ recO era cdd dgkA yqfG pgpH : c-di-AMP phosphodiesterase phoH yqfD yqfC yqfB floA yqeZ yqeY yqeW mtaB rsmE prmA dnaJ dnaK

2,574,000 2,576,000 2,578,000 2,580,000 2,582,000 2,584,000 2,586,000 2,588,000 2,590,000 2,592,000 2,594,000 2,596,000 2,598,000 2,600,000 2,602,000 2,604,000 2,606,000 2,608,000 2,610,000 2,612,000 2,614,000 2,616,000 2,618,000 2,620,000 2,622,000 2,624,000 2,626,000 σEK σA σE σFG σA sdaσA σK σE spoIVCB σE σA yqcE yqbN σtxpAA yqzN yqbG grpE hrcA hemN lepA yqxA spoIIP gpr rpsT holA comEC comEB comEA comER yqeM yqeL yqeK nadD yqeI aroD yqeH yqeG sdaM yqeF cwlH yqeD yqeC yqeB nucB spoIVCA arsC arsB yqcK arsR yqcI rapE rttG rttF yqxJ yqxI cwlA yqxH yqxG yqcD yqcC yqcB yqcA yqbT yqbS yqbR yqbQ yqbP yqbO : putative tape measure protein; skin element ratA yqbM yqbK yqbJ yqbI yqbH

2,628,000 2,630,000 2,632,000 2,634,000 2,636,000 2,638,000 2,640,000 2,642,000 2,644,000 2,646,000 2,648,000 2,650,000 2,652,000 2,654,000 2,656,000 2,658,000 2,660,000 2,662,000 2,664,000 2,666,000 2,668,000 2,670,000 2,672,000 2,674,000 2,676,000 2,678,000 2,680,000 2,682,000 yqbG yqaO yqzO yqaL yqaI yqaF yqaD yrkS yrkI yrkD σK yrkB σA yrzO σA σA yrdDyrdD yqbF yqbE yqbD yqbC yqbB yqbA yqaT yqaS yqaR yqaQ yqaP yqaN yqaM yqaK yqaJ yqaH yqaG sknR yqaC yqaB psiE yrkQ yrkP yrkO yrkN yrkL yrkK yrkJ yrkH yrkF yrkE yrkC bltR blt bltD yrkA yrdR yrdQ yrdP czcD yrdN gltR yrdK brnQ azlD azlC azlB yrdF cypA yrdC yrdB bstE aadK yrpB

2,684,000 2,686,000 2,688,000 2,690,000 2,692,000 2,694,000 2,696,000 2,698,000 2,700,000 2,702,000 2,704,000 2,706,000 2,708,000 2,710,000 2,712,000 2,714,000 2,716,000 2,718,000 2,720,000 2,722,000 2,724,000 2,726,000 2,728,000 2,730,000 2,732,000 2,734,000 2,736,000 σG yraE σM σL σV σWX yrzI yrhC σA σEF yrpB murI yrpD zinT sigZ yrpG yraO yraN yraM csn yraL yraK yraJ yraI yraH yraG yraF adhB yraD adhR adhA yraA sacC : levanase levG levF levE levD levR aapA yrhP yrhO sigV rsiV oatA yrhK cypB : cytochrome P450 CYP102A3 fatR yrhH yrhG yrhF yrhE : putative formate dehydrogenase yrhD mccB mccA mtnN yrrT yrrS pbpI greA

2,738,000 2,740,000 2,742,000 2,744,000 2,746,000 2,748,000 2,750,000 2,752,000 2,754,000 2,756,000 2,758,000 2,760,000 2,762,000 2,764,000 2,766,000 2,768,000 2,770,000 2,772,000 2,774,000 2,776,000 2,778,000 2,780,000 2,782,000 2,784,000 2,786,000 2,788,000 2,790,000 2,792,000 tboA yrzR σG σA ssrSB tboH yrzK σB σB σE σB σE udk trhP1 trhP2 trmR mltG yrzB yrrK yrzL alaS : alanyl-tRNA synthetase yrrI glnQ glnH glnM glnP yrrD recD2 yrrB trmU yrvO cymR rarA tcdA aspS hisS yrvJ dtd relA apt recJ yrvD yrvC secDF comN spoVB yrbG yrzE yrbF tgt queA ruvB ruvA bofC csbX yrbE yrzF yrzH yrbD yrbC coxA safA nadA

2,794,000 2,796,000 2,798,000 2,800,000 2,802,000 2,804,000 2,806,000 2,808,000 2,810,000 2,812,000 2,814,000 2,816,000 2,818,000 2,820,000 2,822,000 2,824,000 2,826,000 2,828,000 2,830,000 2,832,000 2,834,000 2,836,000 2,838,000 2,840,000 2,842,000 2,844,000 2,846,000 σA σE σA σA σA σE σM σA σA yszA σE σA σA σF σA σA σK σB nadC nadB : L-aspartate oxidase nifS nadR pheA thrR obg spo0B rpmA prp rplU spoIVFB spoIVFA minD minC mreD mreC mreB radC maf spoIIB comC folC valS : valyl-tRNA synthetase ysxE spoVID hemL hemB hemD hemC hemX hemA ysxD ysxC lonA lonB clpX tig ddcA leuD leuC leuB leuA ilvC ilvH ilvB ysnD ysnE ysnF ysnB ysnA rph

2,848,000 2,850,000 2,852,000 2,854,000 2,856,000 2,858,000 2,860,000 2,862,000 2,864,000 2,866,000 2,868,000 2,870,000 2,872,000 2,874,000 2,876,000 2,878,000 2,880,000 2,882,000 2,884,000 2,886,000 2,888,000 2,890,000 2,892,000 2,894,000 2,896,000 2,898,000 2,900,000 σG σE σK σA lysCB σA σA σB σA σA σG σA σA σW rpmI σA σD rph gerM racE ysmB ysmA sdhB sdhA sdhC yslB lysC uvrC trxA xsa etfA etfB fadB fadR lcfA yshE mutSB : homologous recombination factor polX yshB zapA rnhC pheT pheS ysgA ysfB glcD glcF ysfE cstA abfA araQ araP araN araM araL araD araB : L-ribulokinase araA abnA ysdC ysdB ysdA rplT infC yscB pftB pftA lytT

2,902,000 2,904,000 2,906,000 2,908,000 2,910,000 2,912,000 2,914,000 2,916,000 2,918,000 2,920,000 2,922,000 2,924,000 2,926,000 2,928,000 2,930,000 2,932,000 2,934,000 2,936,000 2,938,000 2,940,000 2,942,000 2,944,000 2,946,000 2,948,000 2,950,000 2,952,000 2,954,000 2,956,000 σE σA σA σE σA σB σA σE σE σA σB lytS serB thrS : threonyl-tRNA synthetase tboT ytxC ytxB dnaI dnaB nrdR speD gapB ytcD ytbD ytbE coaE ytaF mutM polA : DNA polymerase I phoR phoP mdh icd citZ ytwI ytvI ytzA pyk : pyruvate kinase pfkA accA accD ytsJ dnaE ytrH ytrI nrnA ytpI ytoI ytnM sndA ribR cmoJ cmoI cmoO tcyN tcyM tcyL tcyK tcyJ snaA ascR ytkL ytkK

2,958,000 2,960,000 2,962,000 2,964,000 2,966,000 2,968,000 2,970,000 2,972,000 2,974,000 2,976,000 2,978,000 2,980,000 2,982,000 2,984,000 2,986,000 2,988,000 2,990,000 2,992,000 2,994,000 2,996,000 2,998,000 3,000,000 3,002,000 3,004,000 3,006,000 3,008,000 3,010,000 σA σH ytkK σA σF σW σG σA σA σB σA σA σA σB σA ytlP ytzD argH argG moaB ackA ytxK tpx gerW ytfI sppI sppA ppnKB ytcJ ytcI thiI iscS braB ezrA hisJ refZ ytsP dgcP : diguanylate cyclase rpsD sr7 tyrS tboY acsA : acetyl-CoA synthetase acuA acuB acuC motS motP ccpA aroA brxC ytxH ytxG murC sftA : DNA translocase ytpR ytpQ ytpP ytoQ ytoP ytzB malS ytnP trmB ytzH ytmP amyX : pullulanase ytlR ytlQ

3,012,000 3,014,000 3,016,000 3,018,000 3,020,000 3,022,000 3,024,000 3,026,000 3,028,000 3,030,000 3,032,000 3,034,000 3,036,000 3,038,000 3,040,000 3,042,000 3,044,000 3,046,000 3,048,000 3,050,000 3,052,000 3,054,000 3,056,000 3,058,000 3,060,000 3,062,000 3,064,000 σW ytzE σE σA σA tboL σA σA ytlP ytkP ytjP pbuO ythQ ythP ytzG murJ : lipid II flippase ytfP opuD yteU yteT yteS yteR yteP ytdP ytcQ ytcP ytbQ bioI bioB bioD bioF bioK bioW ytaP melR melE melD melC melA ytwF leuS : leucyl-tRNA synthetase ytvB ytvA yttB yttA bceB bceA bceS bceR ytrF ytrE ytrD ytrC ytrB ytrA ytzC ytqA

3,066,000 3,068,000 3,070,000 3,072,000 3,074,000 3,076,000 3,078,000 3,080,000 3,082,000 3,084,000 3,086,000 3,088,000 3,090,000 3,092,000 3,094,000 3,096,000 3,098,000 3,100,000 3,102,000 3,104,000 3,106,000 3,108,000 3,110,000 3,112,000 3,114,000 3,116,000 3,118,000 3,120,000 σF σB σA σK σA σB ytzI ytjA σA σA σG σK σK σK σE ytqA ytqB ytpB ytpA ytoA alaP : alanine permease asnB metK pckA ytmB ytmA ytlA ytlC ytlD rppH ytkC dps ctaK luxS ytiB ythA ythB mntD mntC mntB mntA menC menE menB menH menD menF yteA ytdA ytcA ytcB ytcC ytxO cotS cotSA cotI ytaB glgP : glycogen phosphorylase glgA glgD glgC glgB rrnB-23S

3,122,000 3,124,000 3,126,000 3,128,000 3,130,000 3,132,000 3,134,000 3,136,000 3,138,000 3,140,000 3,142,000 3,144,000 3,146,000 3,148,000 3,150,000 3,152,000 3,154,000 3,156,000 3,158,000 3,160,000 3,162,000 3,164,000 3,166,000 3,168,000 3,170,000 3,172,000 3,174,000 σA σA σW swdA σA σD σD σD σK σG σA rrnB-23S rrnB-16S thiT yuaI floT yuaF bstB yuaD gbsB gbsA gbsR bslA ktrA ktrB yubF lytG yubD cdoA uppP yubA iolU rhaA rhaM rhaB : rhamnulokinase rhaR rhaEW tlpB mcpA tlpA mcpB tgl yuzH yugU yugT yugS yugP yuzI mstX kbfO yugN yugM pgi yugK yugJ yuzA yugI alaT yugG yugF yugE patB

3,176,000 3,178,000 3,180,000 3,182,000 3,184,000 3,186,000 3,188,000 3,190,000 3,192,000 3,194,000 3,196,000 3,198,000 3,200,000 3,202,000 3,204,000 3,206,000 3,208,000 3,210,000 3,212,000 3,214,000 3,216,000 3,218,000 3,220,000 3,222,000 3,224,000 3,226,000 3,228,000 3,230,000 σA σA yufS σA comX σA σA σE σA yueG σA ybdZ kinB kapB kapD yuxJ pbpD yuxK yufK malK malR nupN nupO nupP nupQ maeN mrpA mrpB mrpC mrpD mrpE mrpF mrpG yuxO comA comP comQ yuzC pdeH pncB pncA yueI yueH yueF yuzE yuzF yueE yueD yueC yueB yukB : ESX secretion system FtsK/SpoIIIE family ATPase yukC yukD yukE adeR ald yukJ dhbF

3,232,000 3,234,000 3,236,000 3,238,000 3,240,000 3,242,000 3,244,000 3,246,000 3,248,000 3,250,000 3,252,000 3,254,000 3,256,000 3,258,000 3,260,000 3,262,000 3,264,000 3,266,000 3,268,000 3,270,000 3,272,000 3,274,000 3,276,000 3,278,000 3,280,000 3,282,000 3,284,000 σA σI σF yuzB σE σA dhbF dhbB dhbE dhbC dhbA besA yuiH bioYB yuiF pepA yuiD yuiC yuiB yumB yumC guaC paiB paiA yutM dapF yutK yutJ yuzD yutI yuxL thrB thrC hom yutH yutG yutF yutE yutD yutC lipA lytH fisB yunC yunD yunE yunF yunG pucH : allantoinase pucR pucJ pucK pucL pucM pucE pucD pucC pucB

3,286,000 3,288,000 3,290,000 3,292,000 3,294,000 3,296,000 3,298,000 3,300,000 3,302,000 3,304,000 3,306,000 3,308,000 3,310,000 3,312,000 3,314,000 3,316,000 3,318,000 3,320,000 3,322,000 3,324,000 3,326,000 3,328,000 3,330,000 3,332,000 3,334,000 3,336,000 3,338,000 σA σGF σA σA σA σK yuzL yusY yusY σA σA spxO σH σA pucB pucA pucG pucF bsn yurJ frlR frlD frlM frlN frlO frlB yurQ yurR yurS glxB yuzN sufB sufU sufS sufD sufC bsrI yurZ metQ metP metN yusD yusE yusF yusG gcvH yusI fadE fadA fadN fadM yuzM yusN mdtR mdtP yusQ yusR yusS yusT yusU yusV yusW yusZ mrgA htrB cssR cssS yuxN fumC gerAA gerAB gerAC

3,340,000 3,342,000 3,344,000 3,346,000 3,348,000 3,350,000 3,352,000 3,354,000 3,356,000 3,358,000 3,360,000 3,362,000 3,364,000 3,366,000 3,368,000 3,370,000 3,372,000 3,374,000 3,376,000 3,378,000 3,380,000 3,382,000 3,384,000 3,386,000 3,388,000 3,390,000 3,392,000 3,394,000 σO σO σA σA σB σO σG σB σA σE σG liaR liaS liaF liaG liaH liaI yvqJ yvqK yvrA yvrB yvrC yvrD yvrE yvrG yvrH rsoA sigO yvrJ oxdC rsiO yvrN yvrO yvrP fhuC fhuG fhuB fhuD lysP : lysine permease yvsG ltaSP yvgK yvgL yvgM yvgN yvgO nhaK : Na+/H+ antiporter cysI cysJ helD : DNA 3'-5' helicase IV yvgT bdbC bdbD cadA copA : Cu+ exporting P-type ATPase csoR iolW azoR2 yvaC yvaD yvaE

3,396,000 3,398,000 3,400,000 3,402,000 3,404,000 3,406,000 3,408,000 3,410,000 3,412,000 3,414,000 3,416,000 3,418,000 3,420,000 3,422,000 3,424,000 3,426,000 3,428,000 3,430,000 3,432,000 3,434,000 3,436,000 3,438,000 3,440,000 3,442,000 3,444,000 3,446,000 3,448,000 σA σB σA yvzC σA σA σA σA σA tboX yvaF yvaG ssrA smpB rnr : ribonuclease R yvaK yvaM rghRA rghRB catR yvaQ opuBD opuBC opuBB opuBA yvaV sdpA sdpB sdpC sdpI sdpR opuCD opuCC opuCB opuCA opcR yvbG yvbH yvbI yvbJ yvbK eno : enolase pgm tpiA pgk gapA cggR araE araR yvbT yvbU cyeB yvbW yvbX lutC lutB lutA yvfU yvfT yvfS yvfR rsbQ rsbP ganB ganA

3,450,000 3,452,000 3,454,000 3,456,000 3,458,000 3,460,000 3,462,000 3,464,000 3,466,000 3,468,000 3,470,000 3,472,000 3,474,000 3,476,000 3,478,000 3,480,000 3,482,000 3,484,000 3,486,000 3,488,000 3,490,000 3,492,000 3,494,000 3,496,000 3,498,000 3,500,000 3,502,000 σB σA σA σW σA σG σG σA ganA ganQ ganP ganS ganR lutR lutP : L-lactate permease sigL epsO epsN epsM epsL epsK epsJ epsI epsH epsG epsF epsE epsD epsC epsB epsA slrR pnbA padC yveG racX pbpE sacB levB yveA yvdT yvdS yvdR yvdQ cotQ cotR clpP mdxM mdxL mdxK : maltose phosphorylase mdxJ mdxG mdxF mdxE mdxD mdxR

3,504,000 3,506,000 3,508,000 3,510,000 3,512,000 3,514,000 3,516,000 3,518,000 3,520,000 3,522,000 3,524,000 3,526,000 3,528,000 3,530,000 3,532,000 3,534,000 3,536,000 3,538,000 3,540,000 3,542,000 3,544,000 3,546,000 3,548,000 3,550,000 3,552,000 3,554,000 3,556,000 3,558,000 yvzJ σA σA σA yvlC σW yvdD yvdC yvdB yvdA yvcT psdB psdA psdS psdR yvcN crh whiA glmR yvcJ yvcI trxB cwlO yvcD bmrA yvzA yvcB yvcA hisI hisF hisA hisH hisB hisD hisG hisZ yvpB pelC yvoF ppaX yvoD lgt hprK nagA nagB nagR yvnB : putative exported hydrolase yvnA cypX yvmC pchR yvmA yvlD yvlB yvlA yvkN yvzB uvrA : excinuclease ABC (subunit A) uvrB

3,560,000 3,562,000 3,564,000 3,566,000 3,568,000 3,570,000 3,572,000 3,574,000 3,576,000 3,578,000 3,580,000 3,582,000 3,584,000 3,586,000 3,588,000 3,590,000 3,592,000 3,594,000 3,596,000 3,598,000 3,600,000 3,602,000 3,604,000 3,606,000 3,608,000 3,610,000 3,612,000 σB σG σB σA σX σA σA swrAA σE σA σH σD σD csrA σA σD σA σA tuaA σA σD σA σB uvrB yvkC : putative phosphotransferase yvkB yvkA minJ swrA ctpB ftsX ftsE cccB yvjA prfB secA : translocase binding subunit (ATPase) hpf smiA fliT fliS fliD yvyC hag fliW yviE flgL flgK flgN flgM yvyF comFC comFB comFA yviA degU degS yvyE tagV tagO tuaH tuaG tuaF tuaE tuaD tuaC tuaB lytC lytB lytA tagU mnaA gtaB ggaB

3,614,000 3,616,000 3,618,000 3,620,000 3,622,000 3,624,000 3,626,000 3,628,000 3,630,000 3,632,000 3,634,000 3,636,000 3,638,000 3,640,000 3,642,000 3,644,000 3,646,000 3,648,000 3,650,000 3,652,000 3,654,000 3,656,000 3,658,000 3,660,000 3,662,000 3,664,000 3,666,000 3,668,000 σK σK yvzI σA yvzE σA σA σD σA σG σB capE σA σA σK σK BSU_36079 σW ywqOywqN ggaB ggaA tagH tagG tagF tagE tagD tagA tagB tagC lytD yvyI gerBA gerBB gerBC ywtG tagT ywtE pgdS capA capC capB rbsR rbsK rbsD rbsA rbsC rbsB ywsB ywsA ywrO alsD alsS alsR ywrK ywrJ cotB cotH cotG ywrF ywrE ywrD chrS chrB chrA

3,670,000 3,672,000 3,674,000 3,676,000 3,678,000 3,680,000 3,682,000 3,684,000 3,686,000 3,688,000 3,690,000 3,692,000 3,694,000 3,696,000 3,698,000 3,700,000 3,702,000 3,704,000σ 3,706,000 3,708,000 3,710,000 3,712,000 3,714,000 3,716,000 3,718,000 3,720,000 3,722,000 σX IσMX σA σE σA σA σA σWX σF σA σH σA csbD σA σB ywqN ywqM ywqL rtbO rtbN ywqI ywqH ywqG ugd ptpZ ptkA tkmA ywqB ywqA phoC glcR ssbB ywpG ywpF ywpE ywpD mscL fabZ rapD flhP flhO mbl ywoH ywoG ywoF pucI : allantoin permease ywoD ywoC ywoB amtB glnK bcrC ywnJ spoIIQ ywnH ywnG ywnF clsA mta ywnC ywnB ywnA ureC ureB ureA ywmF rapB moaA fdhD ywmD ywmC spoIID

3,724,000 3,726,000 3,728,000 3,730,000 3,732,000 3,734,000 3,736,000 3,738,000 3,740,000 3,742,000 3,744,000 3,746,000 3,748,000 3,750,000 3,752,000 3,754,000 3,756,000 3,758,000 3,760,000 3,762,000 3,764,000 3,766,000 3,768,000 3,770,000 3,772,000 3,774,000 3,776,000 σA σE ywzB atpE σA σF σH σA rpmE σH σA σA σA σB σA σA murAA spoIIT ywmA atpC atpD atpG atpA atpH atpF atpB atpI upp glyA ywlG ywlF ywlE ywlD tsaC ywlB spoIIR ywlA ywkF prmC prfA ywkD racA ywkB maeA tdk rho glpX murAB tal fbaA spo0F ywjG pyrG : CTP synthetase rpoE acdA fadF clsB ywjD ywjC ywjB ywjA ywiE narI narJ narH narG arfM ywiC fnr

3,778,000 3,780,000 3,782,000 3,784,000 3,786,000 3,788,000 3,790,000 3,792,000 3,794,000 3,796,000 3,798,000 3,800,000 3,802,000 3,804,000 3,806,000 3,808,000 3,810,000 3,812,000 3,814,000 3,816,000 3,818,000 3,820,000 3,822,000 3,824,000 3,826,000 3,828,000 3,830,000 3,832,000 σFG σFG σA sboXσA albB σA σA σA σA σL σL spsF narK argS ywiB albA albC albD albE albF albG ywhL ywhK rapF ywhH speB speE pbpG ywhD ywhC ywhA thrZ : threonyl-tRNA synthetase mmr ywgB ywgA ywfO rsfA ywfM lipL cysL pta hemQ bacG bacF bacE bacD bacC bacB bacA ywfA rocC rocB rocA rocG sivA spsL spsK spsJ spsI spsG

3,834,000 3,836,000 3,838,000 3,840,000 3,842,000 3,844,000 3,846,000 3,848,000 3,850,000 3,852,000 3,854,000 3,856,000 3,858,000 3,860,000 3,862,000 3,864,000 3,866,000 3,868,000 3,870,000 3,872,000 3,874,000 3,876,000 3,878,000 3,880,000 3,882,000 3,884,000 3,886,000 σK σE σA σA σAD slrA σA ywbE σD spsF spsE spsD spsC spsB spsA gerQ ywdK ywdJ ywdI ywdH ung ywdF ywdE ywdD ywzG pdxK ywdA sacA sacP ywcJ sacT ywcI vpr : extracellular serine protease ywcH nfrA rodA ywcE qoxD qoxC qoxB qoxA ywzA galT galK : galactokinase gtcA ywcC ywcB ywcA ywbO efeB efeO efeU thiE thiM ywbI cidA ywbG ywbF ywbD glxA ywbB ywbA epr

3,888,000 3,890,000 3,892,000 3,894,000 3,896,000 3,898,000 3,900,000 3,902,000 3,904,000 3,906,000 3,908,000 3,910,000 3,912,000 3,914,000 3,916,000 3,918,000 3,920,000 3,922,000 3,924,000 3,926,000 3,928,000 3,930,000 3,932,000 3,934,000 3,936,000 3,938,000 3,940,000 σBF σA σB σW σX σD dltC σA σA yxzF σG yxlE yxlD σY σB σA σW σB σD σA sacX sacY gspA ywaF ywaE tyrZ ywaD sasA menA dltA dltB dltD dltE ilvK licH licA licC licB licR aag katX yxlH yxlG yxlF yxlC sigY yxlA yxkO cydD cydC cydB cydA cimH yxkI yxkH msmX yxkF aldY yxkD yxkC galE yxkA yxjO yxjN yxjM yxjL pepT

3,942,000 3,944,000 3,946,000 3,948,000 3,950,000 3,952,000 3,954,000 3,956,000 3,958,000 3,960,000 3,962,000 3,964,000 3,966,000 3,968,000 3,970,000 3,972,000 3,974,000 3,976,000 3,978,000 3,980,000 3,982,000 3,984,000 3,986,000 3,988,000 3,990,000 3,992,000 3,994,000 3,996,000 σE σA yxiT σB yxzI σA σA σA yxjJ yxjI yxjH yxjG yxjF scoB scoA hbuT tlrB nupG yxiS katE : catalase 2 citH bglS licT yxiP yxiO deaD yxiM yxiK yxiJ yxiI yxzG yxiH yxiG yxzC yxiF wapI wapA : cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor yxxF yxiE bglH bglP yxxE rtbE rtbD yxiC yxiB abnB hutP hutH hutU : urocanase hutI hutG hutM pdp nupC

3,998,000 4,000,000 4,002,000 4,004,000 4,006,000 4,008,000 4,010,000 4,012,000 4,014,000 4,016,000 4,018,000 4,020,000 4,022,000 4,024,000 4,026,000 4,028,000 4,030,000 4,032,000 4,034,000 4,036,000 4,038,000 4,040,000 4,042,000 4,044,000 4,046,000 4,048,000 4,050,000 σA yxeJ σK σG σA σA σB σA σA deoC deoR yxxB yxeR yxeQ sndB yxeO yxeN yxeM snaB yxeK yxeI yxeH yxeG yxeF yxeE yxeD yxeC yxeB yxeA yxdM yxdL yxdK yxdJ iolJ iolI iolH iolG iolF iolE iolD iolC iolB mmsA iolR iolS yxcE yxcD csbC htpG yxcA yxbG yxbF aldX yxbD yxbC srlX yxbB yxbA yxnB asnH yxaM yxaL yxaJ yxaI yxaH

4,052,000 4,054,000 4,056,000 4,058,000 4,060,000 4,062,000 4,064,000 4,066,000 4,068,000 4,070,000 4,072,000 4,074,000 4,076,000 4,078,000 4,080,000 4,082,000 4,084,000 4,086,000 4,088,000 4,090,000 4,092,000 4,094,000 4,096,000 4,098,000 4,100,000 4,102,000 4,104,000 4,106,000 σA σA σA yyzE σA σA yyzF σA σL σA σA σB yycC qdoI qdoR yxnA yxaD yxaK yxaC yxaB glxK gntR gntK : D-gluconate kinase gntP gntZ ahpC ahpF bglA yydK epeB epeA epeP epeE fbp : fructose-1,6-bisphosphatase yydD yydC yydB yydA yycS yycR yycQ yycP yycO yycN rapG argI : arginase rocE rocD rocR htrC walJ walI walH walK walR purA yycE dnaC yycB

4,108,000 4,110,000 4,112,000 4,114,000 4,116,000 4,118,000 4,120,000 4,122,000 4,124,000 4,126,000 4,128,000 4,130,000 4,132,000 4,134,000 4,136,000 4,138,000 4,140,000 4,142,000 4,144,000 4,146,000 4,148,000 4,150,000 4,152,000 4,154,000 4,156,000 4,158,000 4,160,000 σA σK yyzI yyzJ yyzL σA σE σF σA σA yycA rplI gdpP yybS cotF hypR ppaC yybP yybO yybN yybM yybL yybK yybJ yybI yybH yybG yybF yybE yybD yybC yybB yybA yyaT yyaS satA yyaQ yyaP tetB yyaN yyaM yyaL yyaK yyaJ maa yyaH ccpB exoA rpsR ssbA rpsF engD yyaE yyaD yyaC parB parA yyaB noc rsmG trmF trmE jag spoIIIJ rnpA

4,162,000 4,164,000 4,166,000 4,168,000 4,170,000 4,172,000 4,174,000 4,176,000 4,178,000 4,180,000 4,182,000 4,184,000 4,186,000 4,188,000 4,190,000 4,192,000 4,194,000 4,196,000 4,198,000 4,200,000 4,202,000 4,204,000 4,206,000 4,208,000 4,210,000 4,212,000 4,214,000