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Magnetic Resonance Imaging Signs of High Laubner et al. BMC Veterinary Research (2015) 11:181 DOI 10.1186/s12917-015-0479-5 RESEARCH ARTICLE Open Access Magnetic resonance imaging signs of high intraventricular pressure - comparison of findings in dogs with clinically relevant internal hydrocephalus and asymptomatic dogs with ventriculomegaly Steffi Laubner1, Nele Ondreka1, Klaus Failing2, Martin Kramer1 and Martin J. Schmidt1* Abstract Background: Magnetic resonance imaging (MRI) findings of canine brains with enlarged ventricles in asymptomatic dogs were compared to those in dogs with clinically relevant internal hydrocephalus, in order to determine the imaging findings indicative of a relevant increase in intraventricular pressure. Discrimination between clinically relevant hydrocephalus and ventriculomegaly based on MRI findings has not been established yet and is anything but trivial because of the wide variation in ventricular size in different dog breeds and individuals. The MRI scans of the brains of 67 dogs of various breeds, skull conformation and weight were reviewed retrospectively. Based on clinical and imaging findings, the dogs were divided into three groups: a normal group (n = 20), a group with clinically silent ventriculomegaly (n = 25) and a group with severe clinically relevant internal hydrocephalus (n = 22). In addition to the ventricle/brain-index, a number of potential subjective signs of increased intraventricular pressure were recorded and compared between the groups. Results: The ventricle/brain-index was significantly higher in dogs with relevant hydrocephalus (p < 0.001) and a threshold value of 0.6 was specified as a discriminator between internal hydrocephalus and ventriculomegaly. Other MR imaging findings associated with clinically relevant hydrocephalus were an elevation of the corpus callosum (p <0.01), dorsoventral flattening of the interthalamic adhesion (p < 0.0001), periventricular edema (p < 0.0001), dilation of the olfactory recesses (p < 0.0001), thinning of the cortical sulci (p < 0.0001) and/or the subarachnoid space (p < 0.0027) and disruption of the internal capsule adjacent to the caudate nucleus (p < 0.0001). Conclusion: A combination of the abovementioned criteria may support a diagnosis of hydrocephalus that requires treatment. Keywords: Hydrocephalus, Ventriculomegaly, Dog, Intraventricular pressure, Brain malformation * Correspondence: [email protected] 1Department of Veterinary Clinical Sciences, Small Animal Clinic, Justus-Liebig-University, Frankfurter Straße 108, Giessen 35392, Germany Full list of author information is available at the end of the article © 2015 Laubner et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Laubner et al. BMC Veterinary Research (2015) 11:181 Page 2 of 11 Background following criteria. The majority of dogs have very narrow One of the ongoing challenges in veterinary neuroradiol- and slit-like horns of the lateral ventricles. In the finding ogy is to differentiate clinically relevant hydrocephalus of large ventricles/ventriculomegaly, the interpreter sub- from ventricular enlargement in dogs. In fact, large ven- jectively noted a greater proportion of the intracranial vol- tricles are a common incidental finding in brachyceph- ume occupied by the lateral ventricles. The closely spaced alic dog breeds [1–4] and have been referred to as walls of the temporal horns and/or the olfactory recesses “ventriculomegaly” to differentiate this finding from rele- were separated by cerebrospinal fluid (CSF) in these brains vant internal hydrocephalus. These dogs are considered and the lacking of a septum pellucidum created a large to be asymptomatic and are not thought to have associ- connection between the first and second ventricle [17]. ated increased intraventricular pressure (IVP) [5–7]. Dogs in Groups 1 and 2 were examined for diseases not However, there is no threshold level of ventricular vol- primarily related to the brain, as e.g. intraorbital inflam- ume that discriminates the two conditions [8–11]. As- mation, facial nerve paralysis, middle ear disease, etc., or sessment of ventricular size alone is therefore not seizures. None of these dogs showed signs of parenchymal helpful to evaluate whether neurological signs are a po- changes of the brain. Group 3 included 22 dogs with in- tential consequence of brain damage due to an existing ternal hydrocephalus and clinical signs of forebrain disease high IVP and ventricular dilation. This is of particular that subsided after implantation of a ventriculoperitoneal importance because inflammatory/infectious brain dis- shunt. ease, which might be present in addition to ventricular Approval from the ethics committee of the Justus- enlargement and may lack other specific imaging find- Liebig-University was not sought as retrospective studies ings, can remain undetected. Hence, secondary ventricu- of images stored in the archive are not subject to ethical lomegaly is thought to sometimes be misdiagnosed as review. relevant internal hydrocephalus and interpreted to be the cause of clinical signs in dogs affected by inflamma- Imaging technique tory/infectious disorders. Imaging was performed using a 1.0 Tesla MRI scan- Magnetic resonance imaging (MRI) is the method of ner (Phillips Intera Gyroscan, Phillips Healthcare, choice for the assessment of hydrocephalus in humans Hamburg, Germany). Images included sagittal, trans- [12, 13] and animals [14] and has been used as the pri- verse and dorsal T2-weighted (Turbo Spin Echo, TR: mary means of diagnosis for internal hydrocephalus in 1900, TE: 108, slice thickness 3 mm) and transverse our institution. Detailed morphological abnormalities in- fluid-attenuated inversion recovery (FLAIR) sequences dicative of increased IVP beyond ventricular dilation may with three-dimensional Fast Field Echo (FFE) T1- be identified by means of MRI [15, 16]. The aim of this weighted pre- and post-contrast medium administra- study was to determine the morphological and morpho- tion (TR: 588, TE: 15, slice thickness 1 mm). metric findings indicating a high IVP by documenting their presence in MRI studies of dogs with symptomatic Image analysis internal hydrocephalus in contrast to dogs with asymp- Imaging features indicating a high IVP were reviewed re- tomatic ventriculomegaly and normal dogs. ferring to human studies. Furthermore, gross and histo- pathological examinations of the brain of dogs with Methods naturally occurring as well as experimentally induced Animals hydrocephalus yielded characteristic findings assigned to The archive of MRI scans at the Justus Liebig University increased IVP identifiable on MRI scans [18–20]. One (JLU), Germany, was retrospectively searched for MR PhD student and a board certified neurologist reviewed image reports including the diagnoses “within normal the MRI studies for the presence of findings associated limits”, “internal hydrocephalus“and “ventriculomegaly” with internal hydrocephalus for the study groups and or “enlarged ventricles”. MRI reports for each series controls. The experiments were performed using anon- were reviewed by board-certified radiologists. MR im- ymized and randomized image data sets. The observers aging had to include sagittal, transverse and dorsal scans were blinded to the breed and diagnosis of the individual of the entire brain. The sex, age and body weight of the dogs. All of the following measurements/interpretations dogs at the time of scanning were recorded. were made by the two observers independently to deter- Subjects were divided into the following groups. Group mine interobserver variability. 1 included 20 dogs, whose brain and ventricles had been determined to be “within normal limits”.Group2in- Morphological criteria cluded 25 dogs, in which a distension of the lateral cere- bral ventricles had been noted as an incidental finding. 1. Expansion of the third ventricle represented by The presence of ventriculomegaly was based on the flattening of the interthalamic adhesion and a Laubner et al. BMC Veterinary Research (2015) 11:181 Page 3 of 11 diminished suprasellar cistern [3, 21]. A deformation 5. Narrowing of cerebral sulci and obliteration of the of the interthalamic adhesion was assumed when it subarachnoid space around the dorsal convexity of was not distinctly circular on midsagittal plane the cerebral hemispheres [13, 20]. The absence of a images (Fig. 1e). Narrowing of the suprasellar cistern hyperintense subarachnoid space and/or the was diagnosed in transversal images based on the presence of narrowed cortical sulci were recorded lateral bulging contours of the hypothalamus on transverse T2-weighted images at the level of the diminishing the CSF of the adjacent cistern interthalamic adhesion (Fig. 3c). (Fig. 1b/c ). 6. Dilation of the olfactory recess(es) [15, 20, 27]. 2. Disruption of the internal capsule adjacent to the Transverse and dorsal T2-weighted images were caudate nucleus [18]. evaluated for the presence of a hyperintense signal 3. We assessed T2-weighted dorsal images for the (CSF) within the olfactory bulb continuous with the presence of unilateral or bilateral disruption frontal horns of
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