Washington University Record, September 30, 1993

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WASHINGTON UNIVERSITY IN ST LOUIS iecord Vol. 18 No. 6 Sept. 30,1993 Pioneering work is good news/bad news for allergy sufferers Those who dread the sneezin' and wheezin' season — or simply the idea of allergies in general — face a new concern brought to light by a Washington University immunobiologist. Anu Dixit, Ph.D., a National Institutes of Health fellow at Washington University, has identified the allergenic proteins of a little- known but major allergen that, unlike most allergens we're familiar with, is a potential health threat year-round. The allergen, Epicoccum nigrum (EN), is a fungus, not pollen from a flowering plant, and it can be found everywhere — from clothes, to drapes and air-conditioning ducts indoors, to leaves, plants, rocks and soil outdoors. Allergists have known for years that a limited range of fungi (interchange- ably referred to as molds) have allergenic properties. Dixit's study is the first to show that allergenicity to EN is a concern in two climatologically distinct areas of the country — St. Louis and Corpus Christi, Texas. Using a variety of biochemical tools, she also is the first scientist to distinguish allergenicity between the microscopic EN spores (the minute, asexual reproductive bodies) and its mycelia (the threadlike veg- etative bodies), both of which easily become Students compete in the tricycle race during last year's Homecoming celebration. The event will be featured again this year, along with many other activities. Homecoming week is set for Oct. 4-9. airborne. Her work points out the inad- equacy of commercial extracts, which are prepared primarily with fungal mycelia only, in treating allergic patients. Extracts are biochemical potions that contain the aller- Homecoming'93 genic proteins found in a substance. They are used in both skin testing to determine Week recognizes achievement, Teri Clemens named grand marshal allergenicity and in immunotherapy as a People who participate in Homecoming Federko's Bar and Grill, 375 N. Big Bend 1989 and 1992. She also was named the shot to desensitize patients. 1993 can help local flood victims by Blvd., with free food and drinks (the Wash- American Volleyball Coaches Association's "The data suggest that EN is a significant tossing paper airplanes into the air. ington Redskins and the Miami Dolphins 1991 NCAA Division III Coach of the Year. allergen in urban communities," says Dixit. During a new Homecoming event called will play); the ever-popular parade, with Several weeks ago, Clemens notched her "Allergenic proteins occur in both spore and Paper Airplane Toss, participants will buy Teri Clemens, head volleyball coach, as 300th career victory. mycelia, which indicates that both have to be chances to throw their paper airplanes grand marshal; floatbuilding; a tailgate Continuing last year's tradition, students included in the reagents (testing substances) across The Swamp in the South 40. Among party; a pizza-eating contest; a pingpong will elect a Homecoming court. On Sept. for skin testing and immunotherapy for EN other considerations, those who throw their ball drop; Wacky Olympics, complete with 30, elections will be held from 11 a.m. to 1 and probably most allergenic molds." light creations the farthest will win cash a tricycle race and a waiter relay competi- p.m. in Mallinckrodt Center and from 5 to 7 The mold story and other prizes. The toss will be held from tion, among other activities; a dance (for p.m. in Wohl Center. The elections are for a Mold spores in the air typically outnumber 4 to 7 p.m. on Tuesday, Oct. 5. The cost is the Washington community only); a faculty king and queen, to be elected from the pollen by 1,000 to one or more, she adds. 50 cents to sling one plane and $1 to throw appreciation reception; and Homecoming senior class. The court will consist of a There are thousands of different species of three. The Homecoming Steering Commit- Night at The Rat events. (For a complete male and female member from each of the molds. One hundred or so have been associ- tee will provide the paper to make the schedule, seepage 4.) freshman, sophomore and junior classes. ated with allergies, but of these only three airplanes. Event proceeds will benefit local The Homecoming theme is "Only If You The eight court members will be announced have been totally characterized. flood relief efforts. Campus radio station Want It!" The 1993 Homecoming Steering during the Wacky Olympics, which will be "We hope the work we've done with EN KWUR will provide music during the Committee chose the theme "Only If You held from 4 to 5 p.m. Oct. 8 on the law will be a model system for understanding activity. Want It!" for many reasons, said Gobel, a field. The court will ride in the parade and how to characterize mold allergens and "The committee is proud to add the senior majoring in political science and will be recognized and presented prizes eventually to devise more efficient extracts paper airplane toss to the long list of flood psychology. "To us, this saying captures the during halftime at the football game. for immunotherapy," Dixit says. relief efforts occurring at Washington idea of striving to be the best. Hopefully, Continued on page 4 Continued on page 6 University," said Krishna Gobel, publicity people will think about the theme and co-chair for the committee. The committee realize that one can accomplish almost any also wanted to encourage campus-wide goal if one tries." Campus Police assign additional officers support for flood victims, added Lynne Recognizing achievement was on the Tapper, the committee's special events committee members' minds when they to patrol Hilltop following armed robbery chair. selected Clemens as grand marshal, Gobel Homecoming 1993, slated for Oct. 4-9, said. Under Clemens leadership, the volley- Shortly after 8 p.m. Saturday, Julian B. campus is not immune from crime. The also will feature sumo wrestling and The ball team won the National Collegiate Fleischman, Ph.D., associate professor county police and our Campus Police are Hurricane, a money machine game. Athletic Association's (NCAA) Division III of molecular microbiology at the Washing- working diligently to apprehend the person Among the highlights will be the Home- national championship in 1989, making ton University School of Medicine, was responsible for this incident. Patrols on the coming football game, which will be held Clemens the first female coach whose team attacked by an assailant during a robbery campus have been increased. I urge every- at 7 p.m. Oct. 9 in Francis Field when the captured the crown. The Bears also won the on the Hilltop Campus near the northeast one in the University community to be Bears battle Rhodes College of Memphis. championship in 1991 and 1992. For her corner of the Mallinckrodt Center. vigilant and careful," Danforth noted. Other scheduled events include large-screen successes, Asics/Volleyball Monthly named Fleischman was rushed to a hospital for The assailant is described as a black viewings of Monday Night Football at Clemens National Coach of the Year in treatment of multiple stab wounds and is male, 6'1" to 6'2" tall, between 20 and 25 currently reported to be in stable condition years, black hair, short-cropped facial hair, following surgery Saturday night. mustache, dark complexion, thin-to- Washington University Police have medium build, 180 to 190 pounds, wearing In This Issue... assigned additional officers to patrol the a black baseball cap with white writing, Hilltop Campus. Two officers will patrol blue-and-white plaid shirt, dark pants and Detecting heart attacks: School of Medicine researchers develop a the center of campus — either on foot or black boots. Anyone with information new blood test that makes heart attack diagnosis easier Page 2 by motor scooter — each evening. regarding the suspect should contact In a statement released today, Chancel- Detective Robert Marbs of the Campus Opening new doors: David D. Chaplin, M.D., Ph.D., hopes to lor William H. Danforth said "I am Police at 935-5555. control diseases by identifying the genes that cause them Page 3 shocked and saddened by the stabbing. My Identification of the attending hospital heart goes out to Professor Fleischman. and additional details regarding the attack Literary launch: International Writers Center begins reading series, "The safety and well-being of students, are being withheld at this time, pending an which features up-and-coming writers Page 6 faculty, staff and visitors to the campus is investigation by St. Louis County Police, of highest priority. Unfortunately, the which has jurisdiction in the case. 2 Washington University Record Medical Update New blood test makes heart attack diagnosis easier Every year, millions of Americans seek medical attention for symptoms that could point to a heart attack. Their symptoms can stem from a host of problems, from cardiovascular disease to indi- gestion. The physician's challenge is to find the cause — as quickly and accurately as possible. The methods physicians now use to distinguish heart attacks from other medical problems are generally quite reliable, but there are still situations in which diagnosis can be tricky. A new blood test developed at the School of Medicine may help doctors make more accurate decisions, especially in these hard-to-diagnose patients. Among those most likely to benefit are patients who seek treatment late, the investigators say. The test measures blood levels of troponin I (eye), a protein that regulates heart muscle cell contraction. It is known that abnormal levels of troponin I in the blood are a sensitive signal that heart damage has occurred. In this new study of 215 patients, the investigators concluded that elevated levels of troponin I, in contrast to other proteins now used for diagnosis, are only present if heart damage has occurred. Their findings appear in the July issue of Circula- tion. Only about two in 10 people suspected of having a heart attack are actually having one. For more than a decade, physicians have relied on a protein called muscle brain creatine kinase (MB CK), to diagnose heart Allan Jaffe, M.D. examines patient Jimmie Pamplin, who is under treatment for a heart problem. Jaffe is looking for better attacks. Like troponin I, MB CK leaks from diagnostic tests for heart attacks. dying heart cells into the bloodstream; rising blood levels are a signal of a heart evated MB CK for reasons other than heart Using troponin I for late diagnosis could the early 1970s, when Burton Sobel, M.D, attack. But that signal is not completely attack. Of the subjects, 37 had skeletal benefit a substantial number of patients, professor of medicine and director of the foolproof, says Allan S. Jaffe, M.D., profes- muscle injury, 10 had chronic muscle dis- Jaffe says. "The reality is that only a small cardiology division, and Robert Roberts, sor of medicine and senior author of the ease, nine were marathon runners, and 159 percentage of people come in very early M.D, now head of cardiology at Baylor study. had chronic renal disease. This group was after the onset of a heart attack. It's unfortu- University, recognized MB CK as a reliable "MB CK has been a good test, and it's chosen to represent the "tough" potential nate, but it's the truth." Echocardiography marker. Since then, research here has made still very valuable, but it is not perfect," heart attack cases in which MB CK eleva- does not always find heart damage; tropo- the test more clinically practical. Jaffe and Jaffe says. tions are hard to interpret, Jaffe explained. nin I would be more sensitive, faster, his colleagues, including junior associate One limitation is that MB CK can be The goal was to find out whether troponin I, cheaper and more accurate, he adds. Jesse E. Adams, III, M.D, also are evaluat- elevated by damage to skeletal muscle — in like MB CK can be elevated in the absence Patients fare better if they are diagnosed ing other blood markers to help physicians the absence of heart damage, Jaffe explains. of heart damage. and treated within a few hours of the start diagnose heart attacks and monitor certain Because of that, people with chronic muscle The researchers measured troponin I using of an attack, but late diagnosis is still im- heart attack treatments. disease, chronic renal failure or muscle an antibody-based test developed by Jack portant, Jaffe said. During these later — Juli Leistner damage from extremely strenuous exercise Ladenson, Ph.D., a professor of medicine and stages, patients can benefit from many can have elevated MB CK levels, even pathology. They also looked for heart damage treatment options, and they are still at risk when their hearts are healthy. Other problem using echocardiography, an ultrasound exam for additional complications. "Most mortal- cases are car accident victims and some of the heart. Echocardiography is the test ity occurs in the early, acute stage. But there surgery patients. cardiologists typically use when there is is nonetheless substantial mortality that "It is possible to fail to detect cardiac confusion over the cause of elevated MB CK occurs over the course of the first week. injury because someone has had an automo- Although many of the subjects had Heart attacks can extend, or heart failure Record bile accident or has renal failure. Some- elevated levels of MB CK troponin I was can develop," he explains. Diagnosing or times that happens because physicians don't elevated in only the six people who were excluding a heart attack helps physicians Executive Director, know what to make of an elevated level of found to have heart damage, Jaffe said. decide on the best course of treatment. University Communications: Judith Jasper MB CK Is it really due to a heart attack, or Troponin I "should be of value in determin- "What we have done thus far is to show Executive Editor: Susan Killenberg is it simply due to the renal failure? These ing whether elevations of MB CK are in- that troponin I is more specific for heart Editor: Deborah Parker, 935-5235, Box 1070 patients will be very substantially served by dicative of myocardial injury or are a conse- attack in the most overt cases — the pa- Editor, Medical news: Diane Duke, the use of levels of troponin I," Jaffe explains. quence of skeletal muscle damage," the tients that we expect to have elevated MB 362-9662, Medical School Box 8065 In their study, Jaffe and his colleagues investigators concluded in their paper. CK. We are now moving toward looking at Assistant Editor: Carolyn Sanford, looked at 215 people known to have el- Troponin I is not likely to replace MB patients where perhaps subtler abnormali- 935-5293, Box 1070 CK Jaffe says, but may be used with it to ties might be present," Jaffe says. The Contributing writers: Caroline Decker, Jim make a more confident diagnosis. It will Dryden, Gerry Everding, Tony Fitzpatrick, investigators are now looking at troponin I's Nancy Galofre, Jim Keeley, Rozanne Kennedy, Street access limited be especially helpful in patients who seek diagnostic value in trauma and post-opera- Juli Leistner, Dave Moessner, Joni treatment late, he adds. Because MB CK tive patients, who often have minor eleva- Westerhouse and Mike Wolf during construction elevations disappear roughly 24-36 hours tions in MB CK that make the diagnosis of Photographers: Joe Angeles, Tom Heine, after a heart attack starts, patients who come Because of the medical school expan- cardiac injury difficult, he says. David Kilper and Herb Weitman to the hospital after one or two days often sion, there will be a few access and This study is the latest of a long line of Production: Galen Harrison have normal levels. Troponin I, however, parking inconveniences for employees. Washington University contributions to this Record (USPS 600-430;ISSN 1043-0520), stays in the blood for a week or more, he Over the next two years, Scott Avenue area of research. The practice of using MB Volume 18, Number 6/Sept 30,1993. Pub- explained. CK for heart attack diagnosis began here in lished for the faculty, staff and friends of between Euclid and Taylor avenues will Washington University. Produced weekly be closed to through traffic. Pedestrian during the school year, except school holidays, crosswalks will be provided on Scott and monthly during June, July and August by Avenue and near the pedestrian bridge Volunteers needed for diabetes studies the Office of Public Affairs, Washington from Olin Hall to the East Building. University, Campus Box 1070, One Brookings Drive, St. Louis, Mo. 63130. Second-class Handicap parking at the Occupational Researchers at the School of Medicine using diet, those taking pills, and those on postage paid at St Louis, Mo. Therapy Building will be accessible are seeking volunteers for several insulin." Address changes and corrections: from Euclid Avenue. studies involving new treatments for Dietary counseling, free tests and Postmaster and non-employees: Send On Oct. 11, a large part of the parking diabetes. medical exams will be included for volun- address changes to Record, Washington lots just east of the McDonnell Sciences New treatments are being tested in adults teers who qualify for this study. University, Campus Box 1070, One Brookings Building will be closed. Employees must with non-insulin dependent diabetes who In another study, researchers are look- Drive, St. Louis, Mo. 63130. enter the remaining parking spaces from have difficulty controlling blood sugar ing at the genetic defect that causes Type II Hilltop Campus employees: Send to Office McKinley Avenue, and carpool space levels with diet or oral medication, accord- diabetes. Large families with two or more of Human Resources, Washington University, will be moved to the parking lots that are Campus Box 1184, One Brookings Drive, ing to Janet McGill, M.D, an assistant diabetic members are needed for this large St. Louis, Mo. 63130. south of McKinley. Handicap spaces just professor of medicine. project, which is being funded by the 1 Medical Campus Employees: Send to Payroll south of Olin Hall wil be moved adja- "The recent Diabetes Control and Com- National Institutes of Health. Men and Office, Washington University, Campus Box cent to the handicap spaces that now are plications Trial (DCCT) pointed out that women over 30 with Type II diabetes are 8017,660 S. Euclid, St Louis, Mo. 63110. facing McKinley, and handicap spaces in near-normal blood glucose control is the key eligible for the study. the northwest corner of the lot across to preventing the complications of diabetes For more information or to volunteer from the East Building will be moved to such as eye, kidney, and nerve problems," for these studies, call the Washington spaces next to the Library Annex Build- says McGill. "Achieving tight glucose University Diabetes and Hypertension ing. control is important for all patients—those Study Group at 362-8681. WASt^INGIX^-L^IVERSrrY-IN-ST-bDUIS Sept. 30,1993 3

Chaplin searches for disease-causing genes Disease-causing bacteria, viruses and parasites Chaplin's lab is studying the inherited variability of the in an artificial environment outside the human body or ob- exist everywhere in the environment, posing a way the immune system responds by working to identify all serving the action of synthetic IL-1 injected into experimen- constant threat to our health. From the 24- the genes within the MHC. Previous studies have demon- tal animals. These studies have identified many of the po- hour flu to allergies, meningitis and the AIDS strated that the MHC genes control whether an individual is tential activities of IL-1, but they have not defined its natu- virus, the potential for trouble abounds. likely to contract one of more than 200 different diseases. ral function in the body. Most of us can thank our immune system's sophisticated Some of these diseases, such as insulin-dependent diabetes, "If we can better understand how IL-1 works in the body and efficient design for keeping us healthy and helping to rheumatoid arthritis and lupus, appear to be caused by an to regulate inflammation, we'll be able to more thoughtfully heal us when we're ill. The system's intricate network is underlying abnormality of the immune system. Other dis- modify its function," Chaplin says. "First, we need to know wired to recognize and attack foreign invaders while holding eases linked to the MHC, such as narcolepsy and an iron where IL-1 is made and under what conditions it is nor- its line of fire against the body's own cells. metabolism disorder called hemochromatosis, are not re- mally produced in the body." Unfortunately, this complex system sometimes fails. And lated to obvious immune system defects. Investigators studying IL-1 in a test tube and in experi- it isn't always easy to fix. "The underlying mechanisms for most of these diseases mental animals have found that the multifaceted molecules Scientists like David D. Chaplin, M.D., Ph.D, are working aren't well understood," Chaplin says. "We think that many play a role in a variety of activities, many of which promote in the laboratory to understand the genes that control the way of these illnesses are caused by genes located in the MHC inflammatory reactions. IL-1 acts to induce fever, to stimu- the immune system works, or in some cases, why it falters. that have not been discovered yet. Ultimately, knowledge of late the migration of blood cells out of the blood stream and "At the very least, we hope that our work g into tissues, and to activate them to kill and will ultimately help physicians identify | digest microbes. people who are at risk for certain diseases ™ Unlike other signaling molecules that are that result from a defect in the immune sys- released from living cells, IL-1 is released tem, such as insulin-dependent diabetes or from cells that produce it only when they die, rheumatoid arthritis," Chaplin says. "If we Chaplin and his colleagues recently discov- can define all of the genes that control the ered. immune system, it may be possible to de- Perhaps, Chaplin suggests, IL-1 exists to velop therapies to control these types of dis- provide a signal that an activated immune eases, or down the road, to modify the genes cell has been injured and to recruit other to eliminate the problems altogether." immune cells to the injury site. "Cell death Chaplin, an associate professor of medi- may be a more common feature of immune cine, genetics and molecular microbiology at responses than we've realized. Cell death the School of Medicine, learned early the may be entirely normal — and even required important role medical research plays in im- — for the immune system to work," he says. proving people's lives. He had early exposure To learn more about the role of IL-1 in to research through his father, Hugh Chaplin the body, Chaplin and colleagues at the Jr., M.D., who spent 35 years as a researcher, Monsanto Co. are using biotechnology to teacher and administrator at Washington Uni- create a strain of mice that will be unable to versity School of Medicine. produce IL-1. A former director of the Irene Walter By observing how the mice develop, Johnson Institute of Rehabilitation and later researchers can determine how the lack of director of the Barnes Hospital Blood Bank, IL-1 affects the ability of the immune system the elder Chaplin pioneered the development to function. of modern blood-banking methods. He also "If it turns out IL-1 signals cell death, the spent years studying anemias that result from molecule may be important in the normal individuals making antibodies against their maintenance of immune cells that are con- own blood cells. His work enabled many stantly turning over," Chaplin suggests. "We people to undergo blood transfusions with view this as a subject with a lot of unknowns, fewer complications and live more normal but what we learn about IL-1 deficiency may lives. Hugh Chaplin now is professor emeri- give us insights into its role in human dis- tus of pathology and medicine. eases." "I'm sure my father's work influenced my Chaplin's accomplishments in the labora- decision to go to medical school," Chaplin tory are admired by his School of Medicine says. "I always knew that he received great colleagues and by researchers around the satisfaction from his work." country. At the age of 32, Chaplin was se- As a child, Chaplin had occasional oppor- lected to be a prestigious Howard Hughes tunities to work in his father's laboratory and Medical Institute associate investigator. The recalls helping to make reagents that were organization, with assets just shy of $7 bil- used in the blood bank to test the compatibil- lion, carefully selects scientists it believes ity of blood between donors and recipients. will make substantial advancements in basic Chaplin, 41, earned his bachelor's degree biomedical research to pave the way for new in biochemistry from Harvard University in treatments and cures. 1973. He then returned to St. Louis and in "David Chaplin probably knows more 1980 received an M.D. and Ph.D. from the Sanjeev Mariathasan, left, research technician, and David Chaplin, M.D., Ph.D., about the function of IL-1 than anyone in the Medical Scientist Training Program in the review photomicrographs in Chaplin's lab. world," says Robert D. Schreiber, a professor School of Medicine. of pathology and microbiology at the School Since Chaplin entered medical school, scientists have of Medicine. "He's a real authority in this area." made great strides in the field of immunology, with the pace Chaplin is highly regarded for his willingness to collabo- of progress particularly rapid in the past decade. That's par- "Ultimately, knowledge of rate with other scientists and to share information devel- tially because physicians are faced with finding cures for oped in his own laboratory. new immunological challenges, such as the AIDS virus. "He's very good at initiating collaborations with other Equally important have been the recent advances in biotech- all of the genes will lead to scientists, and very generous about letting other labs use nology that now enable researchers to work more efficiently. tools we have developed here," says Michelle Nett "We know a lot more now than we did 10 years ago, or an understanding of the Fiordalisi, a graduate student working in Chaplin's lab. even five years ago," Chaplin says. "But each answer we "I think that's because he has a big picture of science," get opens the door to more questions. To answer the new causes of these diseases." she says. "He's not in science to make a big name for him- questions, we have to bring together individuals with addi- self, but to make a contribution to science." tional skills, to create the new technology. Adapting new Chaplin says collaborations with other researchers are methods to answer scientific problems -— that's what re- important in his field. "We collaborate with people in pedi- search is really all about." all of the genes will lead to an understanding of the causes atrics, pharmacology, pathology and genetics. Those kinds One of immunology's groundbreaking findings was of these diseases." of interactions provide special skills that are critical for me made in the 1940s when researchers studying tissue trans- By the early 1990s, scientists had discovered 60 genes to be able to do my work, and they often are major spring- plantation discovered that a cluster of genes on chromosome located in the MHC region. Collaborative efforts between boards for new progress." six controlled whether or not a graft would be accepted or Chaplin and Yale University colleagues recently have led to Those who work most closely with Chaplin in the labo- rejected. These genes direct the production of molecules that the identification of another 30 genes in the region. Chaplin ratory say he encourages everyone — from technicians to recognize the difference between a part of the body (self) expects an additional 20 to 80 genes will be found. But he postdoctoral students — to think independently. and a foreign threat (non-self). predicts that it will take decades for researchers to deter- "If I have a new idea, I can tell Dr. Chaplin, and he will Together, the genes are referred to as the major histocom- mine the function of all the MHC genes. take me seriously," says Sanjeev Mariathasan, a technician. patibility complex, or MHC for short. Tissue grafts between Chaplin also is working to understand the role a signal- "He feels strongly that the work I do, is not 'my' work, but individuals with identical MHC molecules work, while grafts ing molecule called interleukin-1 (IL-1) plays in helping the 'our' work. For him, collaborating and putting together between people with differing MHC molecules are vigorously immune system do its work. This molecule can stimulate a ideas is more important than the individual recognition." rejected — unless patients receive strong drugs that suppress variety of immune and inflammatory responses. Outside of the laboratory, Chaplin keeps busy in the the immune system's ability to recognize "foreign" tissue. IL-1 has been detected in high levels in the joint fluid of clinic and plays a critical role in screening and recruiting While these findings generated considerable interest individuals with rheumatoid arthritis, bursitis and tendonitis, graduate students to come to Washington University to earn among transplantation biologists, it would be another 20 and is thought to be one of the causes of the swelling and their doctoral degrees in the Division of Biology and Bio- years before researchers would learn that the MHC genes inflammation common to these conditions. Eventually, medical Sciences. Chaplin heads the admissions committee control how the body responds to all types of immune sys- pharmaceutical companies hope to make anti-inflammatory for the graduate studies program, which receives about 650 tem challenges, not just tissue grafts. drugs that will block the production or action of IL-1. For applicants each year for only 70 slots. For example, immunologists know that people with cer- these drugs to be successful, Chaplin believes that much "David Chaplin's commitment in time and energy to the tain MHC types are more likely to sneeze and develop wa- more needs to be learned about the IL-1 molecule. graduate program is extraordinary," says Milton Schlesinger, tery eyes when exposed to ragweed pollen than individuals Most of what researchers know about IL-1 comes from Ph.D., a professor of molecular microbiology at the School with other MHC types. either measuring the production and action of the molecule of Medicine. — Caroline Decker Calendar Sept. 30-Oct. 9

Laboratory of Aerodynamics, Helsinki U. of 9 a.m. Neural sciences seminar. "The Potas- 4 p.m. Molecular microbiology seminar. Technology," Seppo Laine, prof, of aeronau- sium Channel Family Tree Continues to "Regulation of Expression and Functional tical engineering, Helsinki U. of Technology. Grow," David McCobb, research assoc, Dept. Characterization of the Epstein-Barr Virus Room 100 Cupples II. of Anatomy and Neurobiology. Erlanger Aud., Lytic Switch Gene Product Zta," Sam Speck, 4 p.m. Biology and biomedical sciences McDonnell Medical Sciences Bldg. assoc. prof, Dept. of Biology. Room 775 seminar. "Protein Folding on the Missis- McDonnell Medical Sciences Bldg. (Re- sippi," George D. Rose, prof, Dept. of Bio- Monday, Oct. 4 freshments at 3:45 p.m.) chemistry and Molecular Biophysics. 3 p.m. English colloquium. Mary Robison, Erlanger Aud., McDonnell Medical Sciences candidate for a position in fiction. Hurst Wednesday, Oct. 6 Exhibitions Bldg. Lounge, Room 201 Duncker Hall. 7:30 a.m. Obstetrics and Gynecology Grand Rounds. "The Management of 4 p.m. Assembly Series lecture. "The 4 p.m. Biology seminar. "Predicting Gene "Everything Nice: Sugars and Spices in Dispersal From Transgenic Crops: A Chal- Cervical Cancer: An Integrated Approach," Medical History." Through Oct. 1. Glaser United States and the European Community: Leo B. Twiggs, prof, U. of Minnesota. Cooperation and Competition," Theo lenge for Applied Pollination Ecology," Gallery, School of Medicine Library. Hours: William Morris, Dept. of Biology, Duke U, Clopton Aud., 4950 Children's Place. 9 a.m.-9 p.m. weekdays; 1-5 p.m. weekends. Sommer, editor-in-chief, DIE ZEIT, Ham- burg, Germany. Graham Chapel. Durham, N.C. Room 322 Rebstock Hall. 11 a.m. Assembly Series Fall Honors "The Crossing of Borders and the Cre- lecture. "Culture and Crisis in Latin 4 p.m. Central Institute for the Deaf re- 4 p.m. Immunology seminar. "CD28 Medi- ation of Worlds: The Art of Howard ated Costimulation of T Cells: A New Ap- America," Carlos Fuentes, Robert F Jones." Through Oct. 31. Gallery of Art, search seminar. "Intercommunication Kennedy Professor of Latin American Between Cochlear Fluids," Alec N. Salt, asst. proach to Tumor Immunotherapy," James P. upper and lower galleries, Steinberg Hall. Allison, director, Cancer Research Labora- Studies, Harvard U. Graham Chapel. Hours: 10 a.m.-5 p.m. weekdays; 1-5 p.m. prof, Dept. of Oto laryngology. Second Floor Aud., Clinics and Research Bldg. tory, U. of California, Berkeley. Third Floor 3:30 p.m. Joint Center for East Asian weekends. Aud., Children's Hospital Bldg. Studies lecture. "Preschool in Japan," "Shadow Dancing." Oct. 4-10. Rich 4 p.m. Chemistry seminar. "Organometallic Joseph Tobin, prof, of education, U. of Chemistry and Homogeneous Catalysis of 8 p.m. English reading. Mary Robison, O'Donnell, director of the WU electronic candidate for a position in fiction. Hurst Hawaii. Women's Bldg. Lounge. music studio, created the exhibit. Gallery of Rh and Rh-Co Mixed Metal Clusters," Iwao Ojima, Dept. of Chemistry, State U. of New Lounge, Room 201 Duncker Hall. 4 p.m. Biochemistry and molecular bio- Art, lower gallery, Steinberg Hall. Hours: 10 physics seminar. "Inactivation of Cobal- a.m.-5 p.m. weekdays; 1-5 p.m. weekends. York-Stony Brook. Room 311 McMillen 8 p.m. Monday night architecture lecture Lab. (Coffee: 3:40 p.m.) series. "A Survey: The Harris Armstrong amin-dependent Methionine Synthase by Memorial Lecture," Charles Gwathmey, Nitrous Oxide: Death by Laughing," Rowena 4 p.m. History lecture. "Contested Culture: G. Matthews, Dept. of Biological Chemistry, Gentry Ideals and Plebeian Challenge in the architect, Gwathmey, Siegel & Associates, New York. Co-sponsored by Student Union. U. of Michigan, Ann Arbor, Mich. Cori Colonial Virginia Courtroom," David T Aud., 4565 McKinley Ave. Konig, prof, of history. Cohen Lounge, Steinberg Hall Aud. (Reception following in Room 113 Busch Hall. Room 120 Givens Hall.) 4 p.m. Physics colloquium. "Quantum Liquids Films," Eckard Krotscheck, prof, of 4 p.m. Pathology seminar. "Control of Tuesday, Oct. 5 physics, Texas A&M U, College Station, Mammalian Cell Cycle: Cyclins, Kinases, 12:10 p.m. Physical Therapy Brown Bag Texas. Room 204 Crow Hall. (Coffee: 3:30 Tumor Suppressors and Growth Factors," p.m., Room 245 Compton Lab.) Mark E. Ewen, asst. prof, of medicine, Seminar. "Deficits Due to Lesions of Cer- Harvard U, Boston, Mass. Room 7738 ebellar Thalamus," Amy Bastian, doctoral Thursday, Oct. 7 Clinical Sciences Research Bldg. candidate in the Interdisciplinary Program in Films Movement Science. Room 110, Classroom 2:30 p.m. Mechanical engineering 4:30 p.m. Math colloquium. "Bounded C, Boulevard Bldg. colloquium. "Flutter of Grouped Turbine Thursday, Sept. 30 Point Evaluations on Spaces of Analytical Blades," D.S. Whitehead, Ph.D., consultant, Functions," John Conway, prof, U. of Ten- 4 p.m. Anthropology colloquium. "Longitu- 7 and 9 p.m. Filmboard Classic Series. dinal Study of Simian Immuno-def iciency retired from Cambridge U, United King- "Little Caesar." Room 100 Brown Hall. nessee, Knoxville. Room 199 Cupples I. dom. Room 100 Cupples II Hall. Cost: $3. For 24-hour Filmboard hotline, (Tea: 4 p.m., Room 200.) Virus (SIV) in a Wild Monkey Population in call 935-5983. Ethiopia," Jane Phillips-Conroy, assoc. prof., 4 p.m. Earth and planetary sciences Friday, Oct. 1 Dept. of Anatomy and Neurobiology. Room colloquium. "Geochemical and Geophysical 149 McMillan Hall. (Coffee: 3:30 p.m.) Constraints on Depth of Melting Beneath Friday, Oct. 1 9:15 a.m. Pediatric Grand Rounds. 7 and 9:30 p.m. Filmboard Feature Series. "Gaucher Disease: From Erlenmeyer Flasks "A Few Good Men." (Also Oct. 2, same to Designer Genes," Gregory A. Grabowski, times, and Oct. 3 at 7 p.m.) Room 100 prof, of pediatrics and molecular genetics, Brown Hall. Cost: $3. microbiology and biochemistry, U. of Cincin- Homecoming 1993 schedule of events nati College of Medicine and director, Divi- Midnight. Filmboard Midnight Series. Thursday, Homecoming Court Elections, 11 a.m.-l p.m., Mallinckrodt Center; "Sex, Lies and Videotape." (Also Oct. 2, sion of Human Genetics, Cincinnati same time, and Oct. 3 at 9:30 p.m.) Room Children's Hospital Medical Center. Clopton Sept. 30 Homecoming Court Elections, 5-7 p.m., Wohl Center; Rat Night #1 100 Brown Hall. Cost: $3. Aud., 4950 Children's Place. (giveaways), 10 p.m. 11 a.m. Molecular cell biology and bio- Monday, Pizza Tang (Spirit Week competition), 11 a.m.-l p.m., Bowles Plaza; Tuesday, Oct. 5 chemistry thesis defense. "Cloning, Three- Oct. 4 Monday Night Football (Miami Dolphins vs. Washington Redskins), 8 7 p.m. Japanese Film Series. "High and dimensional Structure and Function of p.m., Federko's Bar and Grill, 375 N. Big Bend Blvd. Low," with English subtitles. Room 219 Inositol Polyphosphate 1-Phosphatase," John South Ridgley Hall. D. York, graduate student. Room 8841 Tuesday, Paper Airplane Toss, 4-7 p.m., Swamp; Study Break, 10 p.m., outside of McDonnell Medical Sciences Bldg. Oct. 5 Olin Library. Wednesday, Oct. 6 Noon. Cell biology and physiology semi- Wednesday, Pingpong Drop, 12:30 p.m., Bowles Plaza; Women's tennis vs. St. Louis 7 and 9 p.m. Filmboard Classic Series. nar. "The Rat Liver Canalicular Bile Acid Oct. 6 U, 3:30 p.m., Tao Tennis Center; Women's soccer vs. Maryville U, 7 Chaplin Shorts: "The Floorwalker," "One Transport Protein Is an Ecto-ATPase," Jef- p.m., Francis Field. A.M.," "The Pawnshop" and "The Rink." frey Sippel, asst. prof., Dept. of Pediatrics. (Also Oct. 7, same times.) All films are Room 423 McDonnell Medical Sciences Thursday, Faculty Appreciation Reception, 11 a.m.-l p.m., Lambert Lounge, accompanied by music. Room 100 Brown Bldg. Oct. 7 Mallinckrodt Center; Special Activities (Spirit Week competition), 1-5 p.m., Bowles Plaza; Happy Hour, 4 p.m., Bowles Plaza; Rat Night #2 Hall. Cost: $3. 1 p.m. Solid-state engineering and applied physics seminar. "In-situ Monitoring for (more giveaways), 10 p.m. Friday, Oct. 8 High-precision Polishing of Single-mode Friday, Tie-Dye Fun, 11:30 a.m.-l p.m., Bowles Plaza; Women's Quadrangular 7 and 9:30 p.m. Filmboard Feature Series. Optical Fibers," M. H. Cordaro, electrical Oct. 8 Volleyball Tournament, 3 p.m., Field House; Wacky Olympics, 4-5 "Chaplin." (Also Oct. 9, same times.) Room engineering graduate student. Room 305 p.m., law field; Floatbuilding, 5 p.m., Brookings Hall parking lot, corner 100 Brown Hall. Cost: $3. Bryan Hall. of Millbrook and Skinker boulevards; Men's Soccer vs. MacMurray Midnight. Filmboard Midnight Series. "A 1 p.m. Molecular microbiology and micro- College, 7:30 p.m., Francis Field. Night at the Opera." (Also Oct. 9, same bial pathogenesis thesis defense. "Cellular Saturday, Women's Quadrangular Volleyball Tournament, 9 a.m., Field House; time.) Room 100 Brown Hall. Cost: $3. Mediators of Bordetella pertussis Tracheal Cytotoxin Damage to the Respiratory Epithe- Oct. 9 Women's Soccer vs. Cortland State, 1 p.m., Francis Field; Homecoming lium," Linda Nixon Heiss, graduate student. Parade, 1-3 p.m., beginning at Brookings Hall parking lot, corner of Room 775 McDonnell Medical Sciences Bldg. Millbrook and Skinker boulevards; Tailgate Party, 4-7 p.m., by the Ath- letic Complex; Homecoming Football Game vs. Rhodes College, 7 4 p.m. Anatomy and neurobiology seminar. "A Brief History of Humanity," Glenn p.m., Francis Field; Homecoming Dance, 9 p.m.-l a.m., Bowles Plaza Conroy, Edison Professor of Neurobiology (rain location: Holmes Lounge, Ridgley Hall). and head, Dept. of Anatomy and Neurobiol- ogy. Room 928 McDonnell Medical Sciences Bldg. Homecoming court to be elected -fwmpagei 4 p.m. Biochemistry and molecular biophysics seminar. "Tandem Binding in New The parade will begin at 1 p.m. Oct. 9 in Bend; east on Delmar; south on Skinker; Lectures Cocrystals of trp Repressor With DNA," the Brookings Hall parking lot at the corner and west to the lot. Thursday, Sept. 30 Jannette L. Carey, Dept. of Chemistry, of Millbrook and Skinker boulevards. The Besides Gobel, Kovarik and Tapper, the Princeton U, Princeton, N.J. Room 2918 event will include Six Flags cartoon charac- members of the 1993 committee and their Noon. Genetics seminar. "Technology South Bldg. Development for Automated Multiplex DNA ters, Grand Marshal Teri Clemens riding on responsibilities are: Phil Thompson, chair; Sequencing," Robert Weiss, U. of Utah. Cori 6 and 8:30 p.m. WU Association Travel a horse and carriage, floats, marchers and Danny Kupersmit, publicity; Mark O'Hara, Aud., 4565 McKinley Ave. Lecture Series. "A New England Sampler." two Mercedes-Benz convertibles carrying floatbuilding; Brett Adler, treasurer; Jeremy A photographic and audio travelogue pre- the Homecoming court. For the first time, Spitzberg, Spirit Week; Kelvin Green, grand Noon. Pediatrics research seminar. "Human sented by Woody and Merrillan Thomas, Complement Deficiency," Charles Johnson, the Washington University Pep Band will marshal; Brent Hamlet, tailgate; Jennifer Rochester, N.Y Graham Chapel. Cost: $4.50 perform in the parade, playing music aboard asst. prof, Dept. of Pediatrics. Third Floor at the door. Season passes: $26, single enroll- Burns, dance; and Natasha Dunham, Home- Aud., St. Louis Children's Hospital. ment; $43, double enrollment. For more info, a double-decker bus. "The parade should be coming court. Kim Martino, coordinator of 1:10 p.m. Social work lecture. "Some and to register, call 935-5212. especially fun for everyone," said Julie student activities, is the committee adviser. Perspectives of GWB School of Social Kovarik, the Homecoming committee's University sponsors, in addition to the Work's History," Ralph Morrow, University Saturday, Oct. 2 floatbuilding co-chair. committee, are Office of Student Activities, historian. Brown Hall Lounge. 8 a.m.-5 p.m. Molecular genetics retreat From the Brookings Hall parking lot, the Student Union and Congress of the South 2:30 p.m. Mechanical engineering semi- Cori Aud., McDonnell Medical Sciences parade proceeds as follows: south on Forty. nar. "Computational Fluid Dynamics at the Bldg. For more info., call 362-3364. Skinker; west on Forsyth; north on Big For information, call Gobel at 367-4485. Washington University Record / Sept. 30, 1993 5

Mid-ocean Ridges," Donald W. Forsyth, and 9, same time, and Oct. 3 at 7 p.m.) tus of surgery, and James Hepner, prof, and Cost: $495 for physicians; $395 for allied prof., Dept. of Geological Sciences, Brown Drama Studio, Room 208 Mallinckrodt director, Program in Health Administration. health professionals. Held in Amsterdam, U., Providence, R.I. Room 162 McDonnell Center. Cost: $7 for the general public; $5 (Continues Oct. 2, 8 a.m.-12:30 p.m.) Cost: Holland, Brussels and Belgium. Space is Hall. for senior citizens and WU faculty, staff $350 for physicians; $150 for WU full-time limited. For more info, and to register, call 4 p.m. Chemistry seminar. "Reactions of and students. For ticket info., call and clinical staff. Wohl Aud., 4960 362-6891. [Ir(COD)(PMe3)*]+ With Aromatic and 935-6543. Children's Place. For info., call 362-6893. 9-10:30 a.m. University College short Heteroaromatic Hydrocarbons: C-H Bond course. "Shakespeare's Domestic Dramas," Activation Versus Ring-opening Reactions," Friday, Oct. 8 Saturday, Oct. 2 Nancy Pope, lecturer in English literature. Joseph S. Merola, prof, of chemistry, Vir- 8 p.m. "OVATIONS!" special event. 3 p.m. University College course. "Strate- (Continues on Wednesdays through Nov. 3.) ginia Polytechnic Institute and State U. Sankai Juku performs "Shijima: The Dark- gies for Academic Success," Mary Seager, Cost: $90. For more info., call 935-6788. Room 311 McMillen Lab. ness Calms Down in Space." (Also Oct. 9, prof, of reading, St. Louis Community same time, and Oct. 10 at 2 p.m.) Edison College. Help strengthen study skills for a 5:30-7 p.m. University College career Friday, Oct. 8 Theatre. Cost: $30 for the general public; successful return to college. Room 30 seminar. "Learning for Career Success: $25 for senior citizens and WU faculty, January Hall. Cost: $35 (lunch included). Economics and Business," Ellen Krout 9:15 a.m. Pediatric Grand Rounds. Levine, coordinator of career programs. "Demography and Health: Implications of staff and students. For ticket info., call For more info, and to register, call 935- 935-6543. 6788. Room 30 January Hall. For more info, and Change," Leon Eisenberg, Presley Professor to register, call 935-6788. of Social Medicine and prof, of psychiatry 6:30 p.m. Baha'i Student Association emeritus, Harvard Medical School. Clopton international potluck dinner and slide Aud., 4950 Children's Place. program. "A Travelogue of Iran," pre- Calendar guidelines sented by Marika Csapo-Sweet, asst. prof, Noon. Cell biology and physiology semi- Events sponsored by the University — its nar. "The Retinoblastoma Protein Has Dept. of Telecommunications, U. of Mis- souri-St. Louis. Stix International House. departments, schools, centers, organizations Distinct Domains for Repression and Bind- and its recognized student organizations — ing to the Transcription Factor E2F," Steve (Slide show at 8 p.m.) For more info., call 935-6815. are published in the Calendar. All events are Weintraub, instructor and asst. clinical prof., free and open to the public, unless otherwise Dept. of Pulmonary Medicine. Room 423 noted. McDonnell Medical Sciences Bldg. Sunday, Oct. 3 2-4 p.m. Undergraduate Admission Calendar submissions should state time, Miscellany lecture. "St. Louis Group Meeting." Group date, place, sponsor, title of event, name of information session for prospective fresh- speakers) and affiliation, and admission Friday, Oct. 1 men, led by Angie Yarbrough, senior asst. cost. Quality promotional photographs with European Studies Program conference. director for undergraduate admission. descriptions are welcome. Send items to "Europe After Maastricht: American and Steinberg Hall Aud. For info., call 935-5190. Judy Ruhland at Box 1070 (or via fax: 935- European Perspectives." (Continues 4259). Submission forms are available by through Sunday, Oct. 3.) Various speakers Wednesday, Oct. 6 calling 935-4926. explore American and European perspec- Continuing medical education. "Allergy The deadline for all entries is noon Tuesday tives on the European Community. Abroad — Amsterdam and Brussels," one week prior to publication. Late entries Women's Bldg. Lounge and The Holiday chaired by Phillip E. Korenblat, prof, will not be printed. The Record is printed Inn Clayton Plaza. To register, call 935- emeritus, Dept. of Renal Diseases; Martin every Thursday during the school year, Performances 4360 weekdays between 9 a.m.-l p.m L. Kapsenberg, U. of Amsterdam, Holland; except holidays, and monthly during the and Romain A. Pauwels, prof, of medicine, summer. If you are uncertain about a dead- Friday, Oct. 1 8 a.m.-5 p.m. Continuing medical educa- U. of Gent, Belgium. (Through Oct. 14 tion. "Physician Executive Leadership," line, holiday schedule, or any other informa- 8 p.m. Performing Arts Department with optional extension to Paris, France.) tion, please call 935-4926. production. "Mad Forest." (Also Oct. 2, chaired by Walter F. Ballinger, prof emeri- 6W Club announces University's 1993 Sports Hall of Fame inductees Washington University, in conjunc- teams that had a combined record of 64-26- known for his baseball coaching prowess. In • W. Alfred Hays (Law, 1928)—A tion with its athletic support 3, still holds single-season records for in- 11 seasons as head coach, Utz led the Bears Washington alumnus, generous benefactor organization, the "W" Club, has nings pitched (102.7) and record (8-0). to a 162-66 mark, ranking him first in wins and life trustee, Hayes was a standout foot- announced its second induction class for the • WUbur "Weeb" Ewbank (Football and winning percentage. (Will be inducted ball and track athlete. A successful entrepre- University's Sports Hall of Fame. Coach, 1947-48) — Beginning his colle- posthumously.) neur, philanthropist and noted civic and Induction ceremonies will be held during giate and professional head-coaching career The distinguished service recipients are: community leader, he was characterized "as a luncheon at noon Saturday, Oct. 9, in at Washington, he guided the Bears to a 14- • A. Gwendolyn Drew — Named the one of the University's most loyal and dedi- Ridgley Hall's Holmes Lounge. Washing- 4 record, 9-1 in 1948. He is enshrined in first female full professor on the Hilltop cated supporters." (Will be inducted posthu- ton's football Bears battle Rhodes College at seven halls of fames, including the Profes- Campus in 1950, Drew established Wash- mously.) the 7 p.m. Homecoming game. The induct- sional Football Hall of Fame. Ewbank is the ington's graduate program in physical edu- The selection committee that chose the ees will be recognized at half-time. For lun- only professional football coach to win cation. An annual award was created in her 1993 class is composed of former Washing- cheon or game ticket information, contact world championships in both the NFL and honor recognizing students with superior ton student-athletes representing five differ- the Department of Athletics at 935-5185. AFL — his 1958 and 1959 Baltimore Colts academic standing who have contributed ent eras and current athletic department Washington's Hall of Fame features two won NFL crowns while the 1969 New York positively to varsity athletics. coaches and administrators. categories — one for former student- Jets won the AFL and Super Bowl III titles. athletes, coaches and athletic department • Harvey "Jabo" Jablonsky (Business, administrators, and a second "distinguished 1930) —A 1978 inductee into College service" category for individuals who have Football's Hall of Fame, Jablonsky is sup- significantly advanced the development of posedly the only man to play six years in Washington intercollegiate athletics. college and serve as captain at two schools The 1993 inductees are: — Washington and Army. A guard and line- • Carol Hanks Aucamp (Liberal Arts, backer, he earned Missouri Valley first-team 1965) — Hanks was the first woman to and All-America honors with Washington Football Women's Volleyball (1927-29), and later earned All-America compete on a Washington University men's Last WeCk: Juniata 3 (4,15,15,16), honors at Army (1931-33). (Will be in- Last Week: Rochester 14, Washington 6 varsity team. She compiled career records of Washington 1 (15, 12,13, 14); Wash- ducted posthumously.) 19-5 in singles tennis and 17-3 in doubles, This Week: at Trinity, 7 p.m. Saturday, ington 3 (15, 15,15), Case Western 0 • Stan London (Liberal Arts/Medicine, while playing second and third singles, and Oct. 2, San Antonio, Texas (8,6, 13); Washington 3 (15,15,15), 1949) — Starring in both basketball and number-one doubles. Hanks competed in Current Record: 2-2 Chicago 0 (10, 8,8); Washington 3(15, baseball, London finished his collegiate ath- Wimbledon four times (1961, 1963, 1964, 15,15), Brandeis 0 (3, 3,2); Washing- 1967) and reached the semifinals of the U.S. letic career while enrolled in the School of The Bears' high-scoring offense was ton 3 (15,15,15), Emory 0 (3,1,1); Medicine. He batted a school-record, 465 grounded by Rochester's aggressive, Open in 1964. She earned a world ranking Washington 3 (15, 15,15), New York U. during the 1948 baseball season and earned blitzing defense. Washington, averaging of number nine in 1964. 0 (5,7,7); Washington 3 (15,15,15), • Wray D. Brown (Business, 1922) — honorable mention All-America honors in 425.7 yards per game in total offense, Carnegie-Mellon 0 (1,2,0); Washington basketball. He has served as team physician was held to 191 total yards, including - The sensation of the 1922 intercollegiate 3 (15,15,15), Rochester 0(7,10,1) tennis tournament where he finished as na- for the Baseball Cardinals. 28 yards in rushing. The Bears, re- tional runner-up, Brown captured seven • Carl Snavely (Football Coach, 1953- ceived a pair of field goals from junior This Week: No Activity amateur titles in a 10-year period and 58) — Enshrined in College Football's Hall place-kicker Adam Elegant, Miami Current Record: 21-1 claimed four Missouri Valley Conference of Fame, the "Grey Fox" ranks 24th all-time Beach, Fla. Junior linebacker Matt titles — three in doubles and one in singles. in collegiate football victories with 180. In Gomric, Belleville, 111., led the defense Washington University's NCAA record- In 1925 he was ranked 10th nationally. (Will his 32 seasons as a head coach, he never with 26 tackles, including a school- setting consecutive win streak is over. be inducted posthumously.) experienced a losing season while posting a record 22 solo hits. The top-ranked Bears fell to Juniata • Gb/nn Clark (Liberal Arts, 1934) — record of 180-96-16. Besides coaching at College in Huntingdon, Pa., which A two-sport standout, Clark garnered all- Washington, where he was 33-19, he guided halted the Bears' streak at 59 matches. conference and AP honorable mention All- gridiron programs at Bucknell, North Caro- Men's Soccer Washington also had a 34-match road America kudos in football, and all-confer- lina and Cornell. (Will be inducted posthu- Last Week: Washington 6, Principia 1; streak arid a string of 77 consecutive ence honors in track and field. On the foot- mously.) Washington 2, DePauw 2 (OT) wins versus Division III opponents stopped. ball field, he starred as a tackle on Jimmy • Willis "Bill" H. Summers (Tennis This Week: vs. Webster, 7:30 p.m. Conzelman's famed teams. Clark was the Coach/Athletic Administrator, 1919-62) The Bears rebounded with a new Tuesday, Sept. 28, Francis Field; at' streak, defeating all seven foes in the founding president of St. Louis' Meramec — Summers' 43-year tenure at Washington Rochester, 7:30 p.m. (EDT) Friday, Community College campus in 1964. is the longest of any coach or administrator. UAA Round Robin Tournament in Oct. 1, Rochester, N.Y.; at Brandeis Pittsburgh. • Edward "Bud" Cristal (Engineering, Founder of Washington's intramural pro- University, 1 p.m. (EDT) Sunday, Oct. 1957) — Cristal was the first Washington gram, Summers also coached tennis, swim- 3, Waltham, Mass. basketball player to surpass the 1,000-point ming, fencing, track, golf and wrestling. Women's Soccer plateau, scoring 1,062 points, which ranks During the 1940s and 1950s, he compiled a Current Record: 4-2-1 seventh all-time. He captained the 1955-56 121-30 record as men's tennis coach. From Five of Washington's six goals against Last Week: Wittenberg 3, Washington 0 squad, which posted the second-best win- 1947-49, the Bears won a school-record 31 Principia College were scored by This Week: at Lindenwood College, 7 ning percentage in school history at 17-5 consecutive matches. (Will be inducted freshmen, with first-year players Justin p.m. Monday, Sept. 27, St. Charles, and nearly earned a bid to the NIT tourna- posthumously.) Reed, Kansas City, Mo., and Scott Mo.; at Rochester, 5 p.m. Friday, Oct. ment. • Irv Utz (Baseball/Football Coach, Engroff, Mequon, Wis., tallying two 1, Rochester, N.Y.; at Brandeis, 3 p.m. • Tom Eckelman (Architecture, 1964) 1947-63) — After earning All-America goals apiece. Against DePauw, fresh- Sunday, Oct. 3, Waltham, Mass. — One of Washington's all-time baseball football honors as a quarterback at Michi- man Evan Bowers, Cincinnati, Ohio, Current Record: 2-5-0 greats, Eckelman starred as a record-setting gan, he began an illustrious coaching career, tallied the Bears' first goal before pitcher. He ranks second all-time in pitching which included a 16-year stint with the junior Kevin Neebes, Cleveland, Ohio, Washington, beset with injuries and victories (24), fourth in ERA (2.10), second Bears. Serving as the Bears' head football knotted the game at 2-2. limited depth, has mustered just two in innings pitched (273.7), and fifth in coach for four years (1949-52) and an assis- goals in seven matches this season. strikeouts (179). Eckelman, who played on tant for 12 (1947^8, '53-63), he is best 6 Washington University Record Carlos Fuentes to give Fall Honors address Carlos Fuentes, one of the world's lead- but also a short story writer, essayist, critic, ing literary figures, will address the playwright, journalist and editor. His stories University's Fall Honors Assembly at 11 are collected in Blindman s Song, Burnt a.m. Wednesday, Oct. 6, in Graham Chapel. Water and Constancia and Other Stories for His lecture, "Culture and Crisis in Latin Virgins. In 1992 he wrote and presented the America," is part of the Assembly Series five-hour, five-part, British Broadcasting and is free and open to the public. Corp. television series "The Buried Mirror," Fuentes, Robert F. Kennedy Professor of about the continuity of Hispanic culture. Latin American Studies at Harvard Univer- Educated in law, Fuentes held Mexican I shy, is a noted diplomatic posts during the 1950s, as well Mexican writer as two decades later when he served as and diplomat. The Mexican ambassador to France in the mid- Campaign, pub- 1970s. He is a member of Mexico's Na- lished in 1991, is tional Commission on Human Rights. the most recent in In 1992, Fuentes received the Legion of a long line of Honor, France's highest distinction. His novels that began many other honors include the National I in 1958 with Prize in Literature, Mexico's highest prize Where the Air Is for literature, and Spain's Miguel de I Clear. Others Cervantes Prize for Literature. ' include The Hydra The lecture is co-sponsored by the As- Carlos Fuentes Head, The Death sembly Series, Association of Latin Ameri- ofArtemio Cruz, Terra Nostra, Christopher can Students, International Writers Center, Unborn and The Old Gringo, which became Latin American Studies, Political Society, a 1989 movie starring Jane Fonda and Department of Romance Languages and Gregory Peck. Literatures and Student Union. Fuentes is not only a prolific novelist, For more information, call 935-4620. The Flying Karamazov Brothers will perform "Juggle and Hyde" at 8 p.m. Oct. 13 and 14 in Edison Theatre. Allergy sufferers -fmmpage / Dixit presented a paper on EN this spring "Anu is going to have some of the very Flying Karamazov Brothers juggle at the American Academy of Allergy and best available extracts that will serve as the Immunology Annual Meeting in Chicago, baseline.material for commercial extracts," where she also presented preliminary data Wedner says. "The extracts are urgently with humor, burritos and cleavers on the incidence of cross-reactivity she has needed. Of all people who receive injections found in EN and other allergens. Following The Flying Karamazov Brothers to control their allergies, at least 30 percent right index finger during a perfor- the clues from previous studies that showed want you to know they don't fly, never get better." mance. Not to be deterred by such high degrees of patient sensitivity to EN, are not brothers, are not Russian trifling details, the four Karamazovs Dixit and her colleagues Walter Lewis, Crude extracts and don't just juggle. performed as a seven-handed juggling Ph.D., professor of biology, and H. James Ineffectiveness of commercial extracts and They will, however, be performing group to the amazement of audiences Wedner, M.D., associate professor of medi- relative ignorance of mold spore allergens "Juggle and Hyde," their hilarious and nationwide. They are happy to report are major contributors to this failure rate in transcendental brand of all-around cine, performed aerobiological surveys of that his finger has since rejoined the Corpus Christi and St. Louis. They found treating mold allergies. Of the roughly 40 comic entertainment at 8 p.m. Oct. 13 company, making them once again eight- million Americans that the National Institute and 14 in Edison Theatre. EN to be abundant in the air of both cities. handed. In fact, it was the third most common mold of Allergy and Infectious Diseases says suf- New York Magazine wrote that the What started out as a 10-minute fer from allergies, 19 million are known to Flying Karamazov Brothers "are as spore in St. Louis. street show has expanded into a two- Through skin testing with her own ex- be allergic to plant pollens. The other 20 or nimble of wit as they are deft of hand, hour show that has played in theatres in so million are allergic to anything from dust and your mouth will open wide in tracts that combine both mycelia and spores, Scotland, Australia, Hong Kong, Ber- Dixit determined that 49 of 126 predisposed mites, dander and animals (most notably laughter no less than in awe." muda and Israel, as well as in the cats) to certain foods (suchias dairy prod- In a perennially popular segment patients from St. Louis and Corpus Christi United States. were sensitive to EN. Using a technique ucts), beverages (juices and beer, for in- called "The Gamble," the Karamazovs The OBIE Award-winning called immunoblotting, she tested 17 pa- stance) and fungi. It is unknown how many invite audience members to hand over Karamazovs have created and per- Americans are allergic to molds. Only three objects heavier than an ounce, lighter tients' blood samples and found 44 proteins formed in their own adaptations of that bound the antibody immunoglobulin E genera (common groups) —Alternaria, than 10 pounds and no bigger than a Dumas' "Les Trois Musketeers" (re- Cladosporium and Aspergillus — have been bread box. If the champ, Ivan, keeps (IgE), which tells an allergist whether a per- named The Three Moscowteers), son is allergic to a certain substance. Of identified as allergens, and their proteins the three items flying for the count of 10 Stravinsky's "The Soldier's Tale," and (the cause of allergenicity) purified. then he gets a standing ovation, if he these 44 proteins, six came only from the Shakespeare's "The Comedy of Errors." spores, four only from mycelium and 34 The major drawback to working effec- doesn't he gets a pie in the face. Real Their PBS special "The Flying tively with fungi is their size. They exist in fans come maliciously prepared. Ex- were common to both spores and mycelium. Karamazov Brothers: Stars of New micrometer dimensions, which is half again amples include a foot-long soggy Commercial extracts are very poor in Vaudeville" recently won an Emmy for discerning patient sensitivity between spores what a millimeter (0.039 inches) is. A typical burrito, an orange balloon filled with outstanding entertainment program- single-celled mold spore is about 15 mi- lime jello, and a meat cleaver. and mycelium. Most are based upon mold ming. The Flying Karamazov Brothers mycelial mats grown in large laboratory vats, crometers. Many Alternaria can get up to 25 "Any competent juggler can defy also co-starred in the hit movie "The micrometers, and pollen spores average 25 gravity. Only the Karamazovs can make and thus contain predominately mycelial Jewel of the Nile" as a band of Sufi proteins. Thus, immunotherapy for mold to 30 micrometers. The EN spores Dixit light of it," wrote the Seattle Times. warriors. works with are about 15 micrometers, some The only caveat for "The Gamble" is sensitivity is a hit-and-miss proposition that Tickets are $20 for the general public; has left both doctor and patient puzzled and even smaller. that "the champ will not juggle any live $ 15 for senior citizens and Washington An aerobiological survey involves trap- animals or anything that might stop the too often frustrated. But Dixit has shown that University faculty and staff; and $10 for ping mold samples in the air with an instru- champ from being a live animal." extracts can be made that include both mold students. For more information, call 935- ment called a Burkard sampler, which con- Nevertheless Ivan, the only right- spores and mycelia, covering the whole range 6543. Tickets also are available through sists basically of a piece of tape around a handed Karamazov, severely broke his of allergenic proteins. The Food and Drug Metrotix at 534-1 111. Administration and other bodies now can drum and works like fly paper. Dixit grows consider coming up with standards — cur- the fungal spores on agar plates in liquid cul- rently nonexistent — for commercial extracts. ture. She isolates the spores after seven to 10 Reading series features up-and-coming writers days. She isolates mycelia by growing cul- Era of enlightenment tures in flasks in darkness and gently agitating The International Writers Center at All readings will be followed by book- Her findings are good news/bad news for the flasks. She then identifies the allergy- Washington University will launch signings. allergy sufferers. While she has identified a causing proteins in both the spores and myce- an annual reading series spotlighting Gerald Early, Ph.D., director of the major allergen and is making inroads into lia. She prepares her extracts by fast-freezing up-and-coming writers. The first event, African and Afro-American Studies developing an effective extract for immuno- the molds in liquid nitrogen, pulverizing them which is free and open to the public, Program and professor of English, will therapy, her work opens a Pandora's Box of in a mortar and pestle and then extracting the will feature poet Yusef Komunyakaa introduce Komunyakaa. The author of possible allergens that may be aggravating proteins in a buffer solution. reading from his works at 8 p.m. Mon- eight books of poetry, Komunyakaa's the more than 40 million Americans who In contrast, if she were to develop an day, Oct. 11, in Edison Theatre. latest is Neon Vernacular: New and suffer from allergies. By her own estimate, it extract for oak pollen, a common allergen, "In a way we've made a literary full Selected Poems. The Library Journal has may take 20 years to develop the immuno- all she would need to do is find a flowering circle," said Lorin Cuoco, associate called Komunyakaa a "master at inter- therapy to desensitize patients to the un- oak tree, collect the pollen and suspend it in I director of the weaving memory and history." known numbers of fungi that cause allergies. water to find the allergenic proteins. center and His poems are rich with the details of Dixit's collaborators are well known in "Anu is paramount in the country in iden- series orga- his experiences as an African American, the immunobiology field. Lewis is a world- tifying spores, determining their frequencies nizer. "With Vietnam veteran and jazz lover. renowned expert in aerobiology (the moni- and their allergenic proteins," says Lewis. the local thrust "Komunyakaa defines a culture with toring of aeroparticulates and other organ- "This area of immunology has been ne- of our monthly striking imagery that is often misunder- isms in the atmosphere and their impact on glected in large part because it is extremely literary calen- stood by mainstream readers," wrote humans and the environment), and Wedner difficult. She's becoming a master at it." dar, the inter- Lenard Moore in the Library Journal. is equally well known as an allergist and Dixit says her work underscores three national con- The author's Magic City was selected immunologist. Both scientists consider components that are necessary for proper ferences with by the Village Voice Literary Supple- Dixit's work vital to the understanding and tests for mold allergens. First, define a re- well-known ment as one of the top 25 books of 1992. treatment of mold spore allergies. gion aerobiologically. "Before doctors skin writers and "Komunyakaa draws on his skepticism "Dixit's work will revolutionize this test their patients, they should know what's Yusef Komunyakaa now the annual to produce his dangerous, sensual, nu- whole area of allergies," says Lewis. "There in the air and then apply that information to series spotlighting up-and-coming anced narratives," wrote the Village are so many unanswered questions about the individual clinical diagnosis," she says. writers, we are covering the main areas Voice. mold spores. She could take us out of the Second, consider that both spores and myce- of the literary scene," she said. The series is underwritten in part by 'Dark Ages' into an era of enlightenment." lia are potential allergens. Third, be sure the The International Writers Center the Arts & Education Council of Greater Wedner, who also is a practicing immu- extract is representative of all allergens Reading Series will feature three St. Louis, the Missouri Arts Council, the nologist, notes that Dixit's pioneering work found in a particular mold. additional writers in 1993-94: Ben Okri National Endowment for the Arts and the should increase the knowledge about mold "We hope our work with EN can be the on Nov. 22, Marilyn Chin on Feb. 28 Regional Arts Commission. For more spore allergenicity and enhance the effec- basis for developing more effective extracts," and Jessica Hagedorn on April 11. information, call 935-5576. tiveness of extract preparations. Dixit says. — Tony Fitzpatrick Sept. 30, 1993 7 Introducing new faculty members For The Record The Record is running a series profiling new faculty on the Hilltop and Medical campuses. For The Record contains news about a wide Fascist Movements in Latin America" at the and Representation that was published by variety of faculty, student and staff scholarly 29th meeting of the International Confer- the Cambridge University Press. The book Kathleen Clark, J.D., assistant pro- and professional activities. ence of the Historians of the Labour Move- contains the proceedings of a conference fessor of law, comes to Washington ment held in Linz, Austria.... held at Washington University and is part of University from the U.S. Senate Judi- Of note Murray L. Wax, Ph.D, professor a monograph series published by the ciary Committee in Washington, D.C., Alison Goate, D.Phil., associate professor emeritus of anthropology, will deliver the Cambridge University Press. Barnett serves where she served as counsel. Her of genetics in psychiatry and associate initial address in a lecture series devoted to as editor of the series, which is titled "Inter- research interest is legal ethics. Clark professor in genetics, received a $135,000 "The Concept of Culture and Contempo- national Symposia in Economic Theory and received a bachelor's degree in physics three-year grant from the Alzheimer's rary Issues" at Memphis State University's Econometrics." ... and philosophy in 1984 from Yale Disease and Related Disorders Association Marcus W Orr Center for the Humanities. Suzanne Craft, Ph.D, assistant profes- College, where she graduated cum Inc. for a project titled "Use of Gene Target- His talk, titled "Cultured, High Cultured, sor of psychology, Michael R. DeBaun, laude. She also studied Soviet politics ing to Develop an Animal Model of Multicultured," will be presented Oct. 8. M.D, Ph.D, fellow in hematology/oncology, and Russian language, literature and Alzheimer's Disease." ... Tracy A. Glauser, M.D, former assistant linguistics at the Pushkin Russian During the American Association of On assignment professor of neurology, Benjamin Lee, Language Institute in Moscow in Neurological Surgeons' annual meeting M.D., associate professor of neuroradiology, 1984. She received a law degree from Kathleen E Brickey, J.D, James Can- held in Boston, Sidney Gold ring, M.D, and Jeff Schatz, a graduate student in Yale University in 1990. Professor of Criminal Jurisprudence, has professor emeritus of neurological surgery, been appointed a member of the Associa- psychology, wrote an article titled "Neuro- Russell W. Coff, Ph.D., assistant received The Cushing Medal, the association of American Law Schools' planning psychological Effects of Stroke in Children With Sickle Cell Anemia." The article will professor of organizational behavior, tion's distinguished service award. He is a committee for the Workshop on Criminal comes to Washington from the Uni- past president of the association. In addition, Law, which will be held Oct. 28-30 in be published in the November issue of the Journal of Pediatrics.... versity of California, Los Angeles, he received the Distinguished Service Washington, DC. ... where he received a doctorate in Award from The Society of Neurological Lynn Stockman Imergoot, assistant Stephen R. Crespin, M.D, assistant professor of clinical medicine, was chief management in 1993. His research Surgeons at its annual meeting held in San athletic director, has been named a member focuses on how organizations cope Diego,Calif.... of the Missouri Women in Sports Sciences editor of the School of Medicine's mono- with the fact that their primary assets, Maxine I. Lipeles, J.D., professor (part Leadership Task Force, which aims to graph titled Diabetes and Dyslipidemia: which are people, are unmeasured. time) of environmental regulation and increase opportunities and participation Diagnosis and Treatment. The monograph, Coff received a bachelor's degree in policy, was listed as one of the best environ- rates for women in sports leadership posi- presented by the Office of Continuing economics and psychology in 1983 mental attorneys in The Best Lawyers in tions. ... Medical Education, was part of a nation- from the University of Michigan in America, a book published by Woodward/ Raj Nakra, M.D, professor of psychia- wide program to increase physicians' Ann Arbor, where he graduated with White Inc. of Aiken, S.C. The publication try, was program director of a two-day awareness of lipid problems in diabetic patients. ... high honors and high distinction. lists the best attorneys in 20 categories and seminar titled "Alzheimer's Disease: Ad- includes about 1 percent of the 750,000 vances in Diagnosis and Treatment '93," A 1983 article written by Burton M. Steve Erlebacher, assistant professor lawyers in the United States. Wheeler, Ph.D., professor of English and of of operations and manufacturing man- which was held at the Adam's Mark Hotel in St. Louis. Kathleen Mann Koepke, religious studies, was reprinted in the agement, comes to the University from Speaking of Norton critical edition of Oliver Twist. General Motors Corp.'s research labo- Ph.D., research assistant professor of neurology (psychology), served as program Wheeler's article is titled "The Text and ratories in Warren, Mich., where he Garland E. Allen, Ph.D., professor of Plan of Oliver TwisC was a research consultant. His research biology, was co-organizer of a session titled co-director. The symposium focused on the interests involve designing, planning "Genetics and Agriculture: A Deepening medical, neuropsychiatric and social Etc. and controlling manufacturing, distri- History" at the meeting of the International aspects of the disease. The Washington bution and service systems that are Society for the History, Philosophy and University Department of Psychiatry, John Stewart, associate professor of music, subject to variability. He received a Social Studies of Biology held at Brandeis Alzheimer's Disease Research Center and is judging the Metropolitan Opera District's bachelor's degree in mathematics and University in Waltham, Mass.... Office of Continuing Medical Education auditions being held in Los Angeles. economics from the University of George E. Andersson, assistant dean for were among the seminar sponsors. Illinois in Urbana-Champaign, where finance, and Kenneth A. Robin, director, Guidelines for submitting copy: he graduated summa cum laude in financial information systems, both at the To press Send your full name, complete title, depart- 1988. He received a master's degree in School of Medicine, delivered a case William A. Barnett, Ph.D., professor of ment, phone number, and highest-earned industrial and operations engineering presentation describing the development of economics, Melvin Hinich, Ph.D., a profes- from the University of Michigan in the Washington University Administrative degree, along with a typed description of sor in government at the University of Texas your noteworthy activity to For The Record, Ann Arbor in 1990 and will receive a Information System at the Association of at Austin, and Norman Schofield, D.Litt., c/o Carolyn Sanford, Campus Box 1070. doctorate in industrial and operations American Medical Colleges Group on D.Econ. Sci., Ph.D, Taussig Professor of engineering from the same institution Business Affairs'joint Midwest/Western Items must not exceed 75 words. For infor- Political Economy, edited a book titled mation, call Carolyn Sanford at 935-5293. in December. summer session. The meeting was held in Political Economy: Institution, Competition SantaFe,N.M.... Maurine Linder, Ph.D., assistant Dewey Holten, Ph.D., professor of professor of cell biology and physiol- chemistry, presented a talk titled "Ultrafast ogy, comes to the School of Medicine Electronic and Vibrational Dynamics of Interim co-directors appointed to lead from the University of Texas South- Photoexcited Heme Analogs in the Con- western Medical Center, where she densed and Gas Phases" during the Interna- Business, Law and Economics Center was an instructor of pharmacology. tional Conference on Bioinorganic Chemis- Her research focuses on G proteins, a try held at the University of California, San The John M. Olin School of Business has studied government regulation, com- family of proteins that cells use to Diego. He also presented a talk titled has appointed two Washington mittee decision making and presidential coordinate their internal activities in "Ultrafast Studies of the Photosynthetic University professors as interim co- leadership. response to extracellular signals. She Reaction Center" at the Gordon Research directors of the school's Business, Law and Miller will chair a committee that is received a bachelor's degree in medi- Conference on Organic Photochemistry Economics Center. seeking a new director for the center. cal technology from Michigan State held at Salve Regina University in Rhode Robert B. Thompson, J.D, George Thompson will serve on the search com- University in 1976 and a doctorate Island.... Alexander Madill Professor of Law, and mittee, as will business professors Nicholas from the University of Texas in 1987. Saul Rosenzweig, Ph.D, professor Gary J. Miller, Ph.D., Taylor Professor of Dopuch, Ph.D, James Little, Ph.D, Rachel Schwartz, assistant professor emeritus of psychology and of psychiatry, Political Economy in the Olin School, will Chakravarthi Narasimhan, Ph.D., and eco- of accounting, comes to the University will deliver the keynote address during a co-direct the center until a permanent nomics professor Douglass C. North, Ph.D. from Northwestern University, where panel at the American Psychoanalytic director is found. Don L. Coursey, Ph.D., The Business, Law and Economics she is a doctoral candidate in the J.L. Association's 1994 annual meeting to be center director since 1991, recently re- Center, founded in July 1991, focuses on Kellogg Graduate School of Manage- held in Philadelphia. He will speak on signed to join the University of Chicago how law, economics and politics converge ment. Her research focuses on audit "Freud and Jung in America," the topic of faculty. Jennifer Chilton will continue as to affect the firm. It has served as an um- quality and auditors' liability, and his recent book titled Freud, Jung and Hall the center's assistant director. brella for a range of scholarly activities, accounting and auditing standards the King-maker: The Historic Expedition to Thompson specializes in corporate law, including seminars, research conferences, setting. Schwartz received a bachelor's America (1909).... including securities and business take- working papers and the development of degree in economics and accounting Umashanker Sampath, Ph.D., post- overs. Miller, an organizational theorist, new courses. from Haifa University in Israel in doctoral research associate in chemistry, 1983, an MBA in operations research delivered a poster presentation during the from Tel-Aviv University in Israel in Frontiers in Bioprocessing III conference 1988, and will complete a doctorate in held in Boulder, Colo. His poster was titled accounting from Northwestern in "Chemical Synthesis of Building Blocks for Campus Authors December. Synthetic Ribozymes: Preparation and Characterization of Phosphoramidite 2." He The following is a recent release available at the Campus Bookstore in Mallinckrodt Center on the Hilltop Campus Elizabeth P. Tsunoda, Ph.D., assis- researched the project with James K. or at the Washington University Medical Bookstore in the Olin Residence Hall. For more information, call 935- tant professor of history, comes to Bashkin, Ph.D., assistant professor of 5500 (Hilltop Campus) or 362-3240 (School of Medicine). Washington from Columbia Univer- chemistry.... sity in New York, where she was an At the ACM SIGGRAPH '93/Multime- The volatile country of Lebanon is the subject of a new book by Engin D. Akarli, Ph.D., adjunct assistant professor of history. dia '93 conference held in Anaheim, Calif, associate professor of history. Although Lebanon has been known since the early 19th Her research interests include 20th John L. Schnase, Ph.D, director of the century as one of the most turbulent areas of the world, it nevertheless experienced an century Japanese history, with an Advanced Technology Group in the School interlude of internal peace between its civil war of 1860 and the beginning of the French emphasis on that country's political of Medicine's Library ahd Biomedical Mandate in 1920. In The Long Peace: Ottoman Lebanon, 1861-1920, Akarli examines economy. She received a bachelor's Communications Center, spoke on "Medical the sociopolitical changes resulting from the negotiations and shifting alliances charac- degree in English in 1962 from the Libraries — Projects and Perspectives" teristic of these crucial years. Using previously unexamined Turkish, Arabic and French University of Illinois in Urbana- during a panel titled "Digital Libraries of documents in Ottoman archives, he challenges the prevailing view that attributes mod- Champaign and a master's degree in the Future." With nearly 40,000 people in ernization in government to Western initiative while blaming stagnation on reactionary history from Columbia University in attendance, SIGGRAPH is the country's local forces. Instead, he argues, indigenous Lebanese experience in self-rule as well as 1984. She received a doctorate in largest computer graphics conference.... reconciliation among different religious groups after 1860 laid the foundation for secular democracy. European intervention in Lebanese politics, however, hampered efforts to history from Columbia University in Richard Walter, Ph.D., professor and December 1992. chair of history, presented a paper on develop a correspondingly secular notion of Lebanese nationality. (University of Califor- nia Press, Berkeley, Los Angeles and London). "Labor, Bourgeois-Nationalist, Populist and portunities news

business-related courses, or two years graduate; typing 35 wpm with accuracy; hours per week. Hours will vary with Hilltop Campus business office experience equivalent to an two or more years full- or part-time office workload. Requirements: Associate's The following is a list of positions avail- accounts payable clerk at Washington Uni- experience; computer skills; prefer experi- degree from two-year paralegal or legal able on the Hilltop Campus. Information versity, plus three semester hours of ac- ence with WordPerfect and ALPHAFOUR, assistant program; knowledge of con- regarding these and other positions may counting; high clerical and mathematical Lotus 1-2-3 helpful; excellent oral and tract law, agency law, insurance, patents be obtained in the Office of Human Re- aptitude; good communication skills; expe- written communication skills; and excel- and licensing agreements. Will provide sources, Room 126 North Brookings Hall, rience in the use of mainframe or personal lent customer-service skills. Clerical tests technical review for contracts and or by calling 935-5990. computer accounting applications. Clerical and three letters of recommendation re- agreements between the University and tests and three letters of recommendation quired. third parties, suggesting modifications Assistant Accountant required. to the contracts and agreements as appropriate. 940030. Engineering Accounting. Require- ments: 18 hours of college business courses, Support Center Supervisor Medical Campus 940069. Accounting Services. Require- Medical Research Technician including six hours of accounting course The following is a partial list of positions ments: Associate's degree in related field, 940220-R. Rheumatology. Full time, work; ability to use/willing to be trained to available at the School of Medicine. Em- including two years of basic scientific and may require some overtime. Require- use mainframe computer, including finan- ployees who are interested in submitting cial on-line system (FIS, SIS, ELIG, FO- manual skills as is offered in many technical ments: Bachelor's degree in biology, a transfer request should contact the Hu- institutes and junior colleges, or an equiva- chemistry, molecular biology or related CUS); ability to use personal computer, man Resources Department of the medi- including spreadsheet software (Word- lent degree of on-the-job training; proven field; experience with tissue culture cal school at 362-4920 to request an ap- supervisor ability; demonstrated customer- and/or DNA analysis. Good math skills Perfect); confidence in verbal ability; ability plication. External candidates may call service skills; excellent interpersonal and essential. to deal effectively with University person- 362-7195 for information regarding ap- communication skills; working knowledge nel; typing 45 wpm with accuracy. Clerical plication procedures or may submit a of personal computers; excellent attendance tests and three letters of recommendation resume to the Human Resources office Medical Research Technician required. record; experience with Bell & Howell ABR200 microfilmers, Pitney Bowes 6100 located at 4480 Clayton Ave., Campus 940223-R. Hematology. Requirements: Box 8002, St. Louis, Mo. 63110. Please mail machines, and IBM 3812 laser printers Bachelor's degree with one year experi- Data Processing Assistant I note that the medical school does not is a definite plus. Resume and three letters ence in a molecular biology lab; theo- 940032. University Registrar's Office. of recommendation required. disclose salary information for vacan- retical and practical knowledge of cell Requirements: Some college, bachelor's cies, and the office strongly discourages biology; work with isotopes and poten- degree preferred; experience with comput- inquiries to departments other than Hu- tially toxic solvents, bacteria strains and ers, data processing and an interest in work- Receptionist/Data Entry Clerk man Resources. tissue cell cultures. ing with automated systems; typing with 940072. General Services. Requirements: accuracy. Clerical tests and three letters of High school graduate, some college pre- Medical Research Technologist Financial Aid Assistant recommendation required. ferred; ability to deal cordially with the public, typing 40 wpm with accuracy. Cleri- 940091-R. Neurology. Requirements: 940224-R. Student Affairs. Require- Bachelor's degree with experience in a ments: High school graduate or equiva- Departmental Secretary cal tests and three letters of recommendation required. medical research lab; initiative and judg- lent, some college preferred with ac- 940044. Major Gifts and Capital Projects. ment to make mature decisions; maintain counting and computer-related courses; Requirements: Specialized secretarial and cell cultures and lab; know basic toxicity two years office experience; typing 40 business training; three years of general Secretary/Receptionist protocols. wpm and experience on WordPerfect. office experience; ability to work well in the 940074. University College. Requirements: office environment and relate easily with Two years of college, associate's degree Animal Caretaker Lab Tech Research others; willingness to learn the role of the preferred; typing 50 wpm with accuracy; 940099-R. Comparative Medicine. Tyson 940225-R. Pharmacology. Require- Development Office and the mission of ability to handle multiple tasks and establish Research Center. Schedule: Full time, ments: One year college, bachelor's Washington University; a spirit of teamwork priorities under pressure; ability to meet including some weekends, holidays and degree preferred; should be" familiar and a willingness to assist others as needed; public in a pleasant and professional man- overtime. Requirements: High school with the use of basic laboratory instru- typing 50 wpm with accuracy. Clerical tests ner; stamina (requires some deliveries of graduate or equivalent; must be able to mentation and the ability to interact and three letters of recommendation re- correspondence and packages across cam- work with and handle animals; must have effectively with individuals inside and quired. pus). Clerical tests and three letters of recommendation required. valid driver's license and ability to drive outside the University. truck or van; should have manual skills Receptionist and dexterity and be able to lift up to 50 Secretary I 940064. Alumni and Development Pro- Reference Librarian, Part-time lbs. 940230-R. Transportation. Schedule: grams. Requirements: High school gradu- 940076. Business. Requirements: ALA- Part time, 20 hours per week, usually 9 ate, one to two years secretarial/receptionist accredited MLS. Employee will be respon- Clerk Typist I a.m.-l p.m., but hours may switch as experience or training; typing 40 wpm with sible for all operations in the library during 940118-R. Human Studies. Schedule: Part needed. Requirements: High school accuracy; good command of English lan- the weekend, will implement and interpret time, 20 hours per week, four to five hours graduate or equivalent; good communi- guage; alert, well-spoken, well-groomed, policy. Hours: noon-6 p.m. Saturdays, 1-6 per day. Requirements: High school gradu- cation and customer-service skills; must pleasant, often will be first contact and p.m. Sundays, 3:15-7:15 p.m. two week- ate or equivalent; excellent spelling, punc- have WordPerfect and spreadsheet make first impression on alumni, parents, days. Resume and three letters of recom- tuation and grammar skills, as well as two experience; some knowledge of ac- students, donors and friends of the Univer- mendation required. years related work experience; typing 45 counting procedures; typing 60 wpm. sity and should do so calmly, politely and wpm and experience on word processor. efficiently. Clerical tests and three letters of Departmental Secretary recommendation required. Clinical Lab Tech 940077. Alumni and Development. Require- Systems Operator ments: Associate's degree preferred; typing 940237-R. Obstetrics and Gynecology. Departmental Secretary 50 wpm with accuracy; specialized secre- 940180-R. Surgery. Requirements: High Requirements: Three years of college school graduate or equivalent, associate's with an interest in working in a diag- 940065. Alumni and Development Pro- tarial and business training, three years degree preferred; general knowledge of nostic clinical lab, prefer college gradu- grams. Requirements: Associate's degree, general office experience; good command computer system and network architecture, ate with knowledge of microscope and bachelor's degree preferred; strong back- of English; alert, well-spoken; can deal with as well as knowledge and experience with understanding of human genetics; ground in PC; excellent verbal and written multiple priorities with minimal supervi- PC hardware and operating systems (DOS knowledge of human cytogenetics a skills; pleasant, professional manner with sion; mature, well-groomed, pleasant. Cleri- and Windows). plus. co-workers, volunteers, vendors; able to cal tests and three letters of recommendation handle multiple tasks in an organized, required. accurate and timely manner; able to work Professional Rater II Systems Manager extra hours if necessary; typing 50 wpm Staff Development Officer 940182-R. Psychiatry. Requirements: 940247-R. Internal Medicine. Require- with accuracy. Clerical tests and three letters Master's degree; writing, editing and data 940079. Olin Library. Requirements: ments: High school graduate or equiva- of recommendation required. Master's degree in library science or related analysis skills. Will be involved in multi- lent; bachelor's degree highly preferred. research projects dealing with drug and field preferred; academic background in Individuals with technical certification Circulation Services Assistant personnel administration, adult education, alcohol use and HIV risk behavior. combined with two to three years experience in VAX systems manage- 940067. Olin Library. Requirements: Two psychology or counseling preferred; demon- ment or advanced operational control. years of college-level study or equivalent strated skill in training adults to acquire new Secretary II work experience; library work experience skills; use prior knowledge of training and 940185-R. Ophthalmology. Schedule: Part desirable; ability to communicate effectively maximize transfer; understanding of the role time, 20 hours per week, flexible hours, Clerk I orally and in writing and to deal with the of the research library in higher education; Monday-Friday. Requirements: High 940256-R. Illustration. Schedule: Part public in a consistently pleasant and busi- expertise in library operations preferred; school graduate or equivalent; experience time, 8-11:30 a.m. Monday-Friday. nesslike manner; computer skills, especially sensitivity and responsiveness to staff needs; with Lotus 1-2-3 and Microsoft Word; Requirements: High school graduate or in data entry, desirable; bibliographic skills excellent oral and written communication ability to interact with patients and staff; equivalent; must be people-oriented. and familiarity with foreign languages skills. Application deadline is Nov. 1. Re- typing 50 wpm. Position requires individual to stand desirable; typing 35 wpm with accuracy; sume and three letters of recommendation nearly all the time. Essential that candi- ability to work and resolve patron problems required. Medical Transcriptionist date be on the job at 8 a.m. sharp. under pressure; physical stamina; ability 940199-R. Internal Medicine. Require- and willingness to work flexible hours, Administrative Secretary Clerk I including some evening and weekend hours ments: High school graduate or equivalent 940080. General Services. Requirements: with some experience preferred; knowl- on a regular basis and some split days as 940257-R. Illustration. Schedule: Part Some college preferred; typing 50 wpm required. Clerical tests and three letters of edge of medical terminology; typing 60 time, 1:30-5 p.m. Monday-Friday. with accuracy; excellent secretarial skills. recommendation required. wpm with accuracy; experience with Requirements: High school graduate or Clerical tests and three letters of recommen- WordPerfect 5.1. equivalent; must be people-oriented. dation required. Position requires individual to stand Accounts Payable Processing Clerk Contract Administrator Assistant nearly all the time. Essential that candi- 940068. Accounting Services. Require- date be on the job at 1:30 p.m. sharp. Administration and Recruiting Assistant 940219-R. Assistant Dean, Planning. ments: Six semester hours of accounting 940081. Consortium for Graduate Study in Schedule: Part time, Monday-Friday, 20 and at least six semester hours of additional Management. Requirements: High school