DIPI-MRC Joint Health Research Call Workshop 2016 UK Researchers’ biographies

Dr Rukhsana Ahmed Liverpool School of Tropical Medicine Job Title: Medical Epidemiologist

Email: [email protected]

Dr Ahmed is an epidemiologist who enjoys doing field research. The past three years she has spent in Indonesia managing the clinical trial STOPMiP. During this time she has helped to set up a field site office in collaboration with the Eijkman Institute for Molecular Biology, Jakarta and trained staff to run GCP compliant trial. Prior to this she managed malaria epidemiology projects covering rural areas in Papua province and south west Sumba district and maternal health project in Cianjur, west Java. She has completed a study on malaria rapid diagnostics in Indonesia and is set to finish another study on using LAMP Pan Malaria kits in detecting malaria in pregnant women.

Rukhsana understands the working culture in Asian countries and has added ten years of collaboration experience with stakeholders in Indonesia. She has negotiated with District Health Officers, communicated with village Office and rural communities and held meetings with Ministry of Health Officials. Besides Indonesia, she has carried out operational research in India. With her Asian experience she has developed an ability to foster the challenges of doing research in resource limited areas.

Indonesia is an excellent setting for tropical infectious disease research. Diseases such as dengue, tuberculosis, malaria, soil helminths are endemic in the country. In addition, viruses like Zika, chikungunya and others are emerging in parts of the country. The ethnic and cultural diversity, the large population and spread of islands makes it an exceptional setting for immuno-epidemiology and host genetic studies. On this background and the supportive experience of Indonesian colleagues, she seeks to strengthen existing collaborations while tapping to build new partnerships.

She grew up in the Maldives, obtained her medical degree in Pakistan and completed postgraduate studies in Sydney, Australia. She worked in the United Arab Emirates before she came to the Liverpool School of Tropical Medicine, UK (LSTM) to do her

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Masters in Tropical Paediatrics and continued to complete her doctoral studies in tropical infectious disease at LSTM. During this period Rukhsana had an opportunity to visit Indonesia and immediately took a liking to the country to further her interest in malaria epidemiology studies. Since then she has continued her work in malaria epidemiology, malaria diagnostic and maternal health.

Rukhsana enjoys experiencing different cultural history and has travelled widely in Asia, Europe, Middle East, Africa and covered parts of America. She is global in her education, work and travels and can express herself in English, Hindi, Urdu and Bahasa Indonesia.

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Dr Janet Cox-Singh University of St Andrews Job Title: Senior Lecturer, Infection

Email: [email protected]

The recurrent theme in my research is to harness new technologies to help understand host pathogen dynamics with the aim to tilt the balance towards host survival.

My career began in 1983 with my doctoral research conducted at the Liverpool School of Tropical Medicine. At that time parasite derived variant antigens expressed on the surface of Plasmodium falciparum infected red blood cells were heavily implicated as parasite virulence factors. On completing my PhD I had developed a rodent model for sequestration in malaria, an associated in vitro binding assay for cytoadherence and an in vivo assay to locate new sites of infected cell sequestration in parasite populations expressing variant antigens.

My early postdoctoral career focussed on gaining skills including monoclonal antibody production, cDNA library construction, reverse transcriptase PCR and using these techniques I demonstrated differential stage-specific expression of an important glycoprotein on the surface of Brugia pahangi.

In 1992 I accepted a lectureship at the University Sains Malaysia and had the opportunity to adapt simple blood-spot sampling to molecular epidemiology. I used nested PCR for Plasmodium speciation and to follow the emergence of molecular markers of antimalarial drug resistance in remote malaria prone communities in Malaysia. The methods were also applied to molecular epidemiology studies on Brugia malayi and to investigate Plasmodium species infecting wild and semi-captive Orang utan.

In 1999 I moved to University Malaysia Sarawak (UNIMAS), Malaysian Borneo. The brief there was to establish laboratory-based research in the Faculty of Medicine and Health Sciences. I continued my molecular epidemiology studies and was inspired by the opportunity to study malaria parasites in Borneo, a place of relatively recent geographic isolation and rich in biodiversity.

Undoubtedly my role in the discovery of a large focus of Plasmodium knowlesi, a malaria parasite of old world macaques, in the human population was a career highlight. This find prompted a re-examination of host parasite relationships and of course offered the exciting opportunity to characterise a new type of malaria in the human population. With further support from The Wellcome Trust we found that the entry of P. knowlesi into the human population was not restricted to one location but was widespread across Malaysian Borneo and Peninsular Malaysia. In fact human

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cases of P. knowlesi malaria are now reported across Southeast Asia where the vectors, natural hosts and humans co-exist.

Our team soon discovered that P. knowlesi was not benign but caused severe and fatal malaria that was associated with high parasitaemia. Pathobiology is the focus of my most recent work on P. knowlesi. I continue to apply new technologies to my research questions. Using bioinformatics and allelic typing my group identified invasion gene alleles in P. knowlesi that cluster with markers of disease severity. We are currently transfecting these alleles onto the background of an experimental P. knowlesi line for allele-specific functional studies. In addition we have developed a method to produce high quality P. knowlesi genome sequences from our patient bio-bank that was compiled with MRC funding. Using task-specific computational biology we identified a genome-wide dimorphism in P. knowlesi isolated from human infections.

While in Malaysia I led a team of young scientists and together we embraced new and innovative technologies and applied them to the discovery of P. knowlesi in the human population. This work has generated many opportunities to improve our understanding of severe malaria.

Currently I am interested in exploiting similarity between severe falciparum and severe knowlesi malaria. The prospect that most excites me is to use comparative pathobiology and genomics to inform the development of a much-needed pre-clinical in vivo model for severe malaria.

I am currently based in the Infection Group, School of Medicine, University of St Andrews. The group has adopted new sequencing technologies and bioinformatics to take our research forward. For my work alone genome sequence data from P. knowlesi clinical isolates has made an unprecedented contribution to my understanding of P. knowlesi. For example, I now know that there is a genome-wide dimorphism involving over half of the P. knowlesi genes and, importantly, that one of the dimorphic forms has genetic association with some of the markers of disease severity. Traditional genetic approaches would have taken many years to make this observation if at all possible. Pathogen genomics to support studies on infectious disease is the way forward. I can envisage a fruitful collaboration between the Infection Group, University of St Andrews and Indonesian researchers wishing to develop methodologies to use simple sampling and complex pathogen genomics to answer important research questions on infectious diseases.

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Dr Andrew Davidson University of Bristol Job Title: Senior Lecturer

Email: [email protected]

Dr Andrew Davidson is a Senior Lecturer in Virology in the School of Cellular and Molecular Medicine at the University of Bristol, UK. He has a long standing interest in the study of virus replication and pathogens is with a focus on flaviviruses, specifically dengue virus, and coronaviruses.

He has authored over 30 publications on dengue virus studies. Dr Davidson was appointed as Lecturer in the Department of Microbiology at Monash University, Melbourne in 1992. At this time he commenced studies on dengue virus that continued when he moved to the UK to take up the post of Senior Lecturer in 2002.

He developed one of the first reverse genetic systems for dengue virus which has been widely used both in academia and industry to understand the function of dengue virus proteins and the host response to virus infection as well as for vaccine and antiviral studies. Dr Davidson also developed a reverse genetic system for SARS-coronavirus. More recently, Dr Davidson has been using high-throughput transcriptomic and proteomic approaches to investigate virus-host cell interactions with a focus on flaviviruses and coronaviruses (specifically MERS-coronavirus).

In 2015, Dr Davidson was invited to attend the UK-Filipino Infectious Diseases Workshop held in Manila. Significantly, this led to the development of a collaboration with Dr Raul Destura in the Philippines and Dr McLauchlan at the University of Glasgow which resulted in a successful bid to the MRC –Newton Fund UK-Philippines call which is funded from 2016-2018 and aims to develop prognostic biomarkers for dengue disease severity in the Philippines. Dr Davidson’s team will use an integrated transcriptomics-proteomics approach to analyse clinical samples from the Philippines for the presence of prognostic biomarkers of dengue disease severity.

Dr Davidson also has on-going research collaborations with researchers at Mahidol University, Thailand, the Novartis Institute of Tropical Diseases Research in Singapore and the Institute of Microbiology and Epidemiology, Academy of Military Sciences in Beijing, China. The latter collaboration is currently supported by a Royal Society International Exchange award and Dr Davidson has recently been awarded an Academy of Medical Sciences Newton Advanced Fellowship to further his on-going collaboration with Dr Qin in Beijing to apply high-throughput proteomics to dengue vaccine development. Currently there are three PhD students working in his laboratory funded by government scholarships from Thailand and Saudi Arabia. He is therefore well qualified to represent the broad range of virology and microbiology research interests of the University of Bristol in Indonesia.

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Professor Nick Gay University of Cambridge Job Title: Professor of Molecular and Cellular Biochemistry

Email: [email protected]

For Professor Gay’s Ph.D., he worked with John Walker (who won the 1997 Nobel Prize in Chemistry) on the F1F0-ATPase, at the Medical Research Council LMB in Cambridge (UK). He then spent a postdoctoral period at the University of California at San Francisco (USA), with Tom Kornberg.

Since his return to the UK in 1987, his research group at the University of Cambridge has worked on Toll signalling, initially as a developmental system in Drosophila melanogaster and more recently as a key regulator of innate immunity. They are particularly interested in the molecular mechanisms of TLR signal transduction in severe inflammatory disease driven by sterile and infectious agonists (see1 for a recent review).

Of particular relevance for collaborations with Indonesia are their studies of Gram –ve septicshock, severe sepsis and viral haemorrhagic fever. These are similar acute syndromes that are currently incurable. They have in common a rapid onset of hypotension caused by the disintegration of the vascular endothelium leading to intra- vascular coagulation and multi organ failure2. Inflammatory signalling caused by bacterial, viral or sterile mediators causes or is a major contributor to this failure of vascular integrity. In the case of Ebola shed surface glycoproteins (sGP) that activate TLR4 appear to be central to excessive and dysregulated inflammatory host reactions3.

Likewise, virus non-structural protein 1 (NS1) of Dengue is a pathogen-associated molecular pattern (PAMP). Highly purified NS1 directly activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) via Toll-like receptor 4 (TLR4), leading to the induction and release of pro-inflammatory cytokines and chemokines4. Little is known, however, about the molecular mechanisms involved in protein ligand activation of TLR4.

They propose to define the basis for these critical TLR4 mediated processes, specifically the molecular basis for TLR4 agonism by Ebola sGP and Dengue NS1 and the signalling processes that lead to loss of endothelial integrity, for example by destabilizing tight junctions.

Ebola is a member of the Filoviridae family of negative sense unsegmented RNA viruses. Infection is followed by a largely asymptomatic incubation period of about 20 days during which the virus replicates in macrophages and dendritic cells5.

In this initial phase the virus is able to suppress or subvert innate immune responses mediated by pro-inflammatory cytokines and type 1 interferons6. Subsequently there is

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a very high level of viral replication in hepatocytes and splenocytes and this is accompanied by massive release of cytokines, chemokines and vasoactive substances.

This cytokine storm is central to the pathogenesis of Ebola and leads to a sepsis like syndrome characterized by loss endothelial integrity, intra-vascular coagulation and multi organ failure.

Similarly Dengue infection causes a spectrum of diseases ranging from undifferentiated fever and classical dengue fever to severe and potentially fatal dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Severe disease is characterized by the rapid onset of capillary leak accompanied by thrombocytopenia and altered hemostasis. They will therefore study the molecular basis of TLR4 agonism by Ebola GP and the Dengue NS1 protein using a range of biophysical and structural approaches and will express shed GP1,2 in HEK293 cells using the phCMVGP-HS plasmid. This has a mutation in the TACE processing site that enhances secretion of GP1,2 and allows it to accumulate to around 2mg/ml in supernatants.

They will further purify GP1,2 by gel filtration and ion exchange FPLC and define it’s ligomeric state by analytical ultracentrifugation. A similar approach will be used for NS1. They will then elucidate the mechanism and structural basis by which the ligands recognize and activate TLR4 using surface plasmon resonance (BIACORE) , single molecule and super-resolution microscopy and mass spectrometry. They will also determine the molecular basis of agonism.

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Dr Alain Kohl MRC-University of Glasgow Centre for Virus Research Job Title: MRC Programme Leader

Email: [email protected]

Dr Kohl’s main interest is arbovirus replication, virus-host interactions and innate immune responses to virus infection. The focus of his group’s research is in particular on how arboviruses and mosquitoes interact with emphasis on the antiviral role of small RNA pathways.

This work involves genetic modification of viruses as well cellular and genetic techniques in mosquito cells and mosquitoes. However the lab has expanded into other subject areas, including viral inhibition by Wolbachia endosymbionts and arbovirus interactions with vertebrate cells.

They study arboviruses of all major arbovirus families including Zika, dengue, chikungunya and Rift Valley fever viruses; as models we also frequently use less pathogenic viruses such as Semliki Forest and Bunyamwera viruses. In recent years, mainly through the work of his former PhD student Siwi P. M. Wijyanti who is based in Java/Indonesia, Dr Kohl’s interests have also expanded into mosquito ecology and arbovirus transmission risk analysis.

His group is funded by MRC and BBSRC though grants, core funding and studentships.

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Dr Kevin Maringer University of Surrey Job Title: Lecturer in Microbiology

Email: [email protected]

The research in my new lab at the University of Surrey uses systems-based approaches and novel genomic technologies to understand the molecular interactions between arthropod-borne viruses (arboviruses) and their mosquito vectors. Our work focusses on the mosquito-borne flaviviruses dengue virus and Zika virus, which we compare to other diverse mosquito-borne flavivirus and alphavirus pathogens to elicit a global view of virus-specific and broadly-applicable concepts in arbovirus-vector interactions that underpin the transmission, emergence and spread of vector-borne diseases.

Major Research Programmes include:

• Molecular virus-immune interactions in mosquitoes (sensing and immune antagonism) • Molecular drivers of arbovirus emergence • Development of transmission-incompetent mosquitoes using CRISPR • Novel ‘omics’ tools to study non-model organisms

My professional interest in attending this workshop is to establish new collaborations to together study disease-relevant environmental and clinical viral isolates to elucidate the mechanistic principles behind arbovirus emergence under changing environmental and social conditions in real-world settings. I anticipate that these new collaborations may lead to novel methods of tracking and predicting outbreaks, and vector-based interventions to prevent future epidemics. My most recent projects in particular are focussed on proteomic, transcriptomic and molecular comparisons of diverse Zika virus isolates from across the globe to elucidate molecular determinants driving the rapid emergence of this pathogen. I am keen to build on this ongoing work by tracking molecular mechanisms of emergence in other viruses, and fine-tuning our investigations on dengue virus and Zika virus to understand how environmental and biodiversity changes affect (1) arbovirus-vector interactions, (2) shifts in the vector preference of arboviruses, (3) animal disease reservoirs, and (4) arbovirus evolution, and the consequent emergence of vector-borne diseases. My lab has the expertise and capacity to elucidate fundamental mechanisms of disease in mosquito and animal tissue culture at BSL3 containment (required in the UK for almost all emerging arboviral diseases), and is in the process of establishing facilities to study tropical mosquito species in vivo.

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Biography:

I was recently appointed as a Lecturer in Microbiology at the University of Surrey. My background is in molecular virus-host interactions across diverse virus families

(flaviviruses, alphaviruses, herpesviruses and vesiculoviruses), and I have participated in interdisciplinary multi-centre research in industry and academia. During my PhD at

Imperial College London, funded by an MRC studentship, I characterised protein-protein interactions contributing to herpes simplex virus assembly in the lab of Prof. Gill Elliott. I then secured a Wellcome Trust fellowship to study dengue virus-immune interactions in the labs of Dr. Andrew Davidson

(University of Bristol, UK) and Dr. Ana Fernandez-Sesma (Icahn School of Medicine at Mount Sinai, USA). During my fellowship, I participated in an interdisciplinary collaboration with Prof. Judith Frydman (Stanford University, USA), Dr. Jason Gestwicki and Prof. Raul Andino (both University of California, San Francisco, USA) in which I found that heat shock protein inhibitors are broadly acting antivirals that inhibit diverse flaviviruses, and the aberrant production of cytokines linked to severe dengue disease. In an upcoming publication with Dr. Andrew Davidson and Dr. David Matthews (both University of Bristol), we used a new ‘proteomics informed by transcriptomics’ technique to study the proteome of the important vector mosquito Aedes aegypti. In particular, we probed the genome of this non-model organisms for hotspots of poor annotation, and performed the first ever characterisation of an organism’s ‘mobilome’ (the repertoire of proteins expressed by transposable elements). Over the course of my fellowship I also developed my independent research programme focussed on molecular arbovirus- mosquito interactions underpinning arbovirus emergence (outlined in detail above).

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Dr Peter Monk The University of Sheffield Job Title: Director of International Affairs

Email: [email protected]

I am the Director of International Affairs for the Faculty of Medicine, Dentistry and Health and part of my role is to build new collaborative links across all of our research areas I have strong links with the University Faculties of Science and Engineering here in Sheffield, which share several research institutes with my Faculty.

As an active researcher with more than 80 published papers to date and an h-index of 36, I am also personally interested in opportunities in infectious diseases, working within two multidisciplinary research institutes in Sheffield (Florey and SHAMROK) aimed at the development of new diagnostics and treatments for infectious diseases. Relevant pathogens include viruses (hepatitis C, human papilloma viruses), bacteria (Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Salmonella typhimurium, Burkholderia spp).

In collaboration with a team of materials scientists and engineers, I have developed a novel anti-adhesive therapy for chronic bacterial infection of skin wounds using peptides packaged in a proprietary nanoparticle formulation. This works in combination with conventional antibiotics and is effective even against clinical isolates of methicillin- resistant Staphylococcus aureus (MRSA). The group is also developing high-throughput screening methods for wound-infection therapeutics, promoters of wound-healing and for the analysis of the skin-mediated immune response to infection.

In addition, my research laboratory works on novel anti-inflammatory molecules that will have clinical relevance in diseases ranging from rheumatoid arthritis, obesity and cancer (partly in collaboration with Universiti Putra Malaysia). I have links with pharmaceutical companies and a strong track record of working with industry in translational research.

Institutional Interest in the Workshop

The University of Sheffield has strong interdisciplinary research into infectious diseases, through initiatives such as the Florey Institute for Host Pathogen Interactions (http://www.floreyinstitute.com/) and the Sheffield Antimicrobial Resistance Network (SHAMROK, http://www.shamrok.org/), which focus on biological, physical and physico- chemical approaches to bacteriology, with the aims of preventing infections and delivering effective anti-microbial drugs and vaccines. The Medical School and the Bateson Centre (http://www.sheffield.ac.uk/bateson) collaborate on innovative animal models, including zebrafish models of mycobacteria and Staphylococcus aureus infection, and the interaction between pathogens such as respiratory syncytial virus or HIV with streptococci. Medical School researchers also work on the host immune responses to infection, and molecular

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pathology of organisms such as Burkholderia pseudomallei (melioidosis), an under- recognised disease in Indonesia. Control of the inflammation initiated by flaviviruses (e.g. dengue and Zika) and rhinoviruses is also a current research topic in the Medical School.

Substantial funding from EPSRC, BBSRC and MRC provide powerful techniques for the study of infections at the molecular level, including super-resolution, electron and atomic force microscopy (within the University’s Imagine Institute, http://www.imagine- imaginglife.com/), led by life and physical scientists.

The University’s School of Health and Related Research (ScHARR) works with the MRC Gambia Unit, trialling a novel intervention for malarial transmission hotspots and the subsequent systematic treatment of cases in the vicinity. ScHARR also provides modelling of infectious diseases, in particular paediatric tuberculosis and TB interactions with HIV-1, and health economic modelling of disease treatments. The Department of Infection, Immunity and Cardiovascular Diseases is also involved in an influenza vaccine trail in Gambia. HIV, HTLV and Epstein-Barr virus infections in Africa are also studied, developing techniques that could be applied in Indonesia.

All of the University's research into infectious diseases is directly linked to the Academic Directorate for Communicable Diseases within Sheffield Teaching Hospitals NHS Foundation, Trust with clinician scientists working in both spheres having access to large patient cohorts and the latest technical advances.

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Dr Puja Myles University of Nottingham Job Title: Associate Professor, Health Protection and Epidemiology

Email: [email protected]

Dr Puja Myles is Associate Professor of Health Protection and Epidemiology and is based in the Health Protection and Influenza Research Group (HPIRG) within the University of Nottingham’s School of Medicine. The Group, chaired by Professor Jonathan Nguyen Van- Tam (a global influenza expert with a strong public health policy background), is a WHO Collaborating Centre for Pandemic Influenza Research.

Dr Myles is a Public Health Specialist and Epidemiologist and her areas of expertise include public health, epidemiological methods, respiratory epidemiology, particularly, influenza and pneumonia; infectious disease surveillance, evaluation of public health interventions and global health. Dr Puja Myles will represent the University of Nottingham’s interest at the UK-Indonesia Joint Health Research Call workshop in Jakarta.

The HPIRG has research interests spanning a broad range of communicable diseases areas, but specialises in respiratory virus infections, of which influenza is the key strategic focus. The group researches all aspects of influenza but particularly influenza transmission, pandemic preparedness, vaccines and anti-viral drugs. Dr Myles’ work has included the testing of a set of community assessment triage tools in both the UK and Nigeria that could prioritise patients for treatment based on severity and that could be used with minimal training in the field.

Another project evaluated the impact of a community development intervention on childhood immunisation uptake among slum-dwelling migrant populations in India. Further on-going collaborative research in Nigeria involves an implementation evaluation of the WHO integrated Management of Childhood Illnesses (IMCI) guidelines for the early diagnosis and treatment of pneumonia and malaria in under-5s. She has experience of establishing and analysing large surveillance datasets and one of her current projects includes real-time analysis of routine surveillance and patient care databases to inform planning in the event of another pandemic.

Dr Myles has led an international pandemic influenza research consortium of 83 global research partners (The Post-pandemic review of anti-influenza drug effectiveness or the PRIDE research consortium) and has experience of data harmonisation with global pandemic influenza surveillance datasets as well as research in low and middle income countries including factors influencing clinical decision making and the trade-offs between diagnostic accuracy, costs and population coverage to inform diagnostic strategies for childhood pneumonia and malaria in resource constrained settings.

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More information about her and the HPIRG group can be found here: http://www.nottingham.ac.uk/research/groups/healthprotection/index.aspx.

The group would especially welcome research collaborations in the area of respiratory infections, particularly, influenza-like illness, malaria and ICT/e-health solutions for infectious disease surveillance.

Dr Myles will also be representing the multidisciplinary Emerging Infections Research Group led by Professor Jonathan Ball (Molecular Virologist) which seeks to promote, improve, and defend the health and well-being of all species by enhancing cooperation and collaboration between human and animal clinicians, and other scientific health and environmental professionals through the integration of human and veterinary medicine and biological and environmental sciences.

There are numerous examples where human health is related to the health of animals and the environment. Emerging infections are an increasing threat and many are zoonotic; animals share human susceptibility to infections from other animals as well as threats from climate change. Nottingham has world-leading expertise in cognate and synergistic areas alluded to above. It has excellent veterinary and human medical staff and facilities.

Major capabilities exist in the disciplines of bacteriology, virology and parasitology. Nottingham is also blessed with outstanding expertise in evolution and ecology, ecosystem sciences and other environmental sciences, public health and health economics, disease modelling and social sciences. This group would welcome collaboration with groups interested in research at the pathogen – host interface and how global factors such as trade and climate change influence this process.

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Dr Saseendran Pallikadavath The University of Portsmouth Job Title: Executive Director

Email: [email protected]

Dr Saseendran Pallikadavath, Reader in Demography and Global Health, University of Portsmouth & Executive Director, Portsmouth-Brawijaya Centre for Global Health, Population and Policy, Malang, Indonesia.

Dr Pallikadavath is an anthropologist-demographer. He obtained his PhD in demography from the Australian National University (ANU), Canberra. He is interested in substantive and methodological issues in maternal and child health, adolescent health, health inequalities, sexual and reproductive health, health systems, low fertility and international female migration in low and middle income countries. His current methodological interest is in Implementation Research in health.

He is the principal investigator of a research grant worth £1 million funded by the UK Medical Research Council (MRC) under the MRC Global Programme in Maternal and Child Health. This study examines the impact of demand side financing (DSF) instruments on maternal and child health (MNCH) in India and Bangladesh. He is also the principal investigator of another Newton Fund in partnership with the University of Brawijaya, Indonesia. This project examines the impact of international female migration from Indonesia on the left-behind population. He is a co-investigator of the Portsmouth Birth Cohort study which examines early life, and its impact on subsequent health and well- being. He recently concluded an ESRC Seminar Series on low fertility with the University of St Andrews and the University of Oxford. He is a recipient of prestigious research grants from British Academy, British Council, ESRC, MRC, DFID, Nuffield Foundation, and UK local Governments.

Dr Pallikadavath is the chief editor of a special Journal of Biosocial Sciences (JBS) volume on “Causes and implications of low fertility in developing countries”. He has published his research in high impact journals such and Health Policy and Planning, Social Science and Medicine, AIDS, AIDS Care, Fertility and Sterility, International Family Planning Perspectives, Journal of Population Research, Journal of Biosocial Sciences, Health Promotion International etc.

He is currently a Senior Fellow of the ESRC peer review college. He served on the bilateral panel of the National Institute of Health (NIH), USA. He also severed as a senior research advisor for the National Institute of Health Research (NIHR) funded Research Design Services (RSD) for over 5 years.

He supervised several PhDs on global health and is currently developing a Masters Programme on Global Health Research Methods to be delivered at Portsmouth and

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Indonesia. His technical skills include analysis of large scale data sets, inequality analysis, modelling,

and implementation research. His collaborative research span over Africa, South Asia, South America and South East Asia.

Dr Pallikadavath is the founding executive director of the Portsmouth-Brawijaya Centre for Global Health, Population and Policy through his Newton Institutional Link Award.

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Dr Ranjan Ramasamy Anglia Ruskin University Job Title: Reader in Biomedical Sciences

Email: [email protected]

Dr Ramasamy has been working on vectors and vector-borne diseases in endemic area countries (Kenya, Sri Lanka), Brunei, USA and Australia and continue to do so from the UK.

On-going research includes: 1. Salinity adaptation in the arboviral vectors Aedes aegypti and Aedes albopictus and the impact of salinity adaptation on disease transmission: With collaborators in the University of Jaffna in Sri Lanka, I have shown that these two arboviral vectors, that were previously considered to develop only in fresh water collections surrounding human dwellings, are also able to develop in brackish water (up to 1.7% salt) in coastal areas of Asian countries. Our observations have been independently confirmed subsequently in the coast of Florida, USA and Brazil. Adaptation to brackish water has a significant effect on the prevalence of arboviral diseases such as dengue, chikungunya and Zika because WHO and national vector control guidelines have only focussed on fresh water larval habitats. I have also proposed the relevance of these observations to rising sea levels consequent to global climate change.

2. The role of α-galactosyl epitopes in protective immunity against malaria: Data from my own work and those of others now suggest that natural antibodies to α-galactosyl epitopes provide a degree of protection against infection.

3. Application of ribosomal RNA-based FISH diagnostic tests for infectious diseases: In collaboration with colleagues in the United States, I am investigating the use of FISH diagnostics for malaria, human and bovine tuberculosis, human leishmaniasis and differentiating sibling species of malaria vectors. The advantages are that these do not require specialised equipment and are suitable for use in small-endemic area diagnostic laboratories.

My relevant previous appointment have included Professor Biochemistry in the University of Jaffna, Sri Lanka, NWO Visiting Professor at the Universities of Nijmegen and Groningen in the Netherlands, and Professor of Immunology in the Universiti Brunei Darussalam, Brunei Darussalam. I have previously participated in two Malaysia- Indonesia-Brunei medical research workshops that were held in Brunei and Malaysia. Dr Ramasamy is interested in collaborating with Indonesian researchers in examining the value of FISH-based diagnostics in the field, particularly for Plasmodium knowlesi. Collaboration in areas pertaining to my other research interests are also possible. Attending the workshop will be very helpful in this regard, if there is a corresponding interest among Indonesian scientists.

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Dr Colin Sutherland London School of Hygiene & Tropical Medicine Job Title: Head, Dept of Immunology & Infection

Email: [email protected]

Dr Sutherland joined the London School of Hygiene & Tropical Medicine in January 1998 as a Research Fellow to work with Prof Geoffrey Targett on the adhesion of Plasmodium falciparum gametocytes. Colin coordinated a series of Wellcome Trust-funded clinical trials which measured the effect of antimalarial combination therapy on transmission of P. falciparum in Farafenni, The Gambia from 2000 to 2002.

This led further work focussed on parasite drug resistance in several African countries within the Gates Malaria Partnership from 2000 - 2008. Since 2004 Colin has contributed to the work of the Public Health England Malaria Reference Laboratory in LSHTM, and is an honorary Clinical Scientist at the Department of Clinical Parasitology, Hospital for Tropical Disease, London, where he has contributed to the development of new molecular diagnostics for malaria and in studies of the genetics/genomics of all Plasmodium species that infect humans.

The Sutherland research group in the Department of Immunology & Infection at LSHTM comprises 3 PhD students, 3 Post-docs and 1 Technician, and has current research projects on:

1) the genetics, genomics & epidemiology of ovale malaria 2) potential of gametocyte stages of P. falciparum as targets of chemotherapy and vaccine-elicited immunity 3) genetic polymorphisms in P. falciparum associated with resistance to ACT drugs in vivo 4) in vitro drug susceptibility of P. falciparum and P. knowlesi 5) molecular genetics of drug resistance in P. falciparum in North Sumatera, Indonesia 6) molecular genetics, genomics and epidemiology of Plasmodium knowlesi among human hosts in Indonesia

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Dr Andrew Tuplin University of Leeds Job Title: HEFCE funded Lecturer and Principle Investigator

Email: [email protected]

Dr Tuplin has >15 years’ experience using reverse genetics to study positive-strand RNA viruses, focusing on the function and structure of RNA replication elements and dynamic RNA-RNA/RNA-protein interactions in controlling virus genome replication and translation.

During his PhD (University of Edinburgh) he used bioinformatic and biochemical methods to define and map essential RNA elements in the genome of hepatitis C virus (HCV). He then took up a post-doctoral position at CEH-Oxford (formally the Institute for Invertebrate Virology in Oxford), investigating the molecular biology and transmission of tick-born encephalitis virus and related mosquito vectored flaviviruses.

Subsequently, Dr Tuplin began a second post-doctoral position at the University of Warwick before promotion to senior research fellow. Using a combination of RNA SHAPE mapping, biochemical assays, reverse genetics and mass spectroscopy, he demonstrated that dynamic pseudoknot structures in the HCV genome form alternative long range RNA-RNA and RNA-protein interactions - acting as a riboswitch to control virus translation and genome replication. He demonstrated the potential of this riboswitch as a novel therapeutic target, leading to two patent applications and translational proof of concept funding from Warwick Ventures Ltd.

In 2013 Dr Tuplin was appointed to the position of Lecturer and Principal Investigator at the University of Leeds, one of the leading Virology Groups in the UK. Primarily focused on mosquito vectored dengue and chikungunya viruses (both major public health priorities for Indonesia), research in his group is investigating how RNA elements within viral genomes interact with host/viral proteins and other RNA elements, to control virus translation and genome replication.

Furthermore, they have funding to investigate the potential of such essential RNA elements/interactions as novel therapeutic targets to inhibit chikungunya and dengue virus replication. They have expertise in a wide range of cutting edge molecular, structural and cell biology techniques. As a member of the Astbury Centre for Structural and Molecular Biology Dr Tuplin works within a multidisciplinary grouping with expertise across physics, biological sciences and chemistry – providing a dynamic environment in which to conduct world-leading molecular virology research.

Emphasizing this, within the Astbury Centre he has a joint PhD student with Dr Zhuravleva and Prof Harris; using NMR and X-ray crystallography (in collaboration with Dr Cockburn) to investigate the conformational dynamics of interactions between the dengue virus genome and its polymerase.

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They have funding for a further PhD student to conduct similar collaborative research on Zika virus. Research in his group is funded through a Royal Society project grant (Inhibition of chikungunya virus replication using compounds that target and disrupt essential viral RNA structures) and an MRC New Investigator Research Grant (Mechanistic analysis of RNA-replication elements involved in early stages of chikungunya virus replication). MRC- and BBSRC- training partnerships support three PhD studentships in the group, working on collaborative projects (with Prof's Harris and Stonehouse) investigating the molecular biology of flavivirus and chikungunya virus replication.

Dr Tuplin’s track record in flavivirus (dengue, yellow fever and tick-borne-encephalitis viruses), chikungunya and HCV research is highly synergistic with two of workshop's main focuses; namely 'Dengue, dengue-like illness and other vector-borne diseases' and ' Hepatitis'. He is particularly interested in the opportunity presented by this call to combine his research, on fundamental aspects of RNA virus replication and rational drug design, with the epidemiological and clinical sample screening expertise of Indonesian institutions - such as the Eijkman Institute for Molecular Biology in Jakarta. Collaborative research with the dengue and/or emerging virus units of the Eijkman or similar Indonesian institutions would provide valuable opportunities for analyzing RNA element/host cell interactions and their potential as novel therapeutic targets, across panels genetically divergent clinical isolates.

Furthermore, as a representative of the word leading Virology Group at the University of Leeds, Dr Tuplin would envisage fostering collaborations, between Indonesian researchers and other research groups within the Astbury Centre for Structural and Molecular Biology, investigating how access to our state of the art equipment - such as 950-MHz NMR and cryo-EM facilities – would be advantageous to Indonesian researchers.

Vaccine scaffold technologies being developed by Prof's Stonehouse and Rowlands are directly applicable to dengue and chikungunya and Prof Harris has active projects targeting key replication proteins of HCV, chikungunya and Ebola virus as antiviral targets. In addition, Dr McKimmie, a newly recruited University Academic Fellow, whose research focuses on defining fundamental processes and functions of innate immunity, chemokines and leukocyte migration in initiating early stages of arboviral infections (specifically chikungunya and dengue virus) would also be a highly relevant collaboration partner.

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Dr Zisis Kozlakidis University College London Job Title: INNOVATION FELLOW – ICONIC Project Manager

Email: [email protected]

Dr Zisis Kozlakidis is a virologist, with a PhD in microbiology from Imperial College London followed by working experience in the design of viral diagnostics, the running of academic facilities within hospitals and the adoption of innovation in routine healthcare.

His expertise in viral co-infections, diagnostics and characterisation of novel RNA viral species was acknowledged by being elected fellow of the Linnean Society, Royal Academy, in 2015. His joint projects with the INDOHUN Network of Public Health Schools in Indonesia have resulted in the UCL Knowledge Exchange Champion 2016 Award. A central aim of his Indonesian work is the investigation of infectious diseases while increasing local capacity in infectious diseases research.

Zisis has significant expertise in the archival preservation of viral species and biobanking. He established the Infectious Diseases Biobank and currently serves as the President of the International Society of Biological and Environmental repositories (ISBER); as chairman of the Science and Innovation section of the ESBB (European Society of Biobanking) and he is the representative of the UK to the EU on Biomolecular Infrastucture on Infectious Diseases and on relations with China. His involvement in biobanking, clinical data linkage to banked material, ethics and public engagement were been central in being awarded the Associateship of King’s College London.

His contribution to the financial and operational aspects of integrating services facilities within academic and healthcare environments and the overall adoption of innovation on the NHS has led to his award of an Executive MBA for the Cass Business School, City University London. He has provided operating feasibility advice on such facilities in a number of different countries including Germany, the US, Vietnam and China. Zisis current work at UCL /UCLH involves the development and integration of next generation sequencing practices in routine healthcare. The routine linkage of this data to clinical records is expected to inform infection control practices and their associated financial impact(s). The viral genomic analyses provide evidence for the transmission and development of resistance within viral species, through the emergence of viral recombinants and the associated implications to public health.

This work is relevant to developed as well as developing countries, during routine surveillance as well as infectious diseases outbreaks and has led to numerous collaborations globally.

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DIPI-MRC Joint Health Research Call Workshop 2016

Indonesia Researchers’ biographies

Professor Irawan Yusuf Hasanuddin University, Makassar Job title: Professor in Physiology, Faculty of Medicine

Email: [email protected]

Prof. Irawan Yusuf, MD, PhD (Hiroshima University Japan) is a senior scientist at Dept. of Physiology. He was also a Senior Scientist at Eijkman Institute for Molecular Biology in Jakarta (1995-2002).

Prof. Yusuf has served in a number of boards or /commitees at national level. Among them were as Deputy Head for National Ethic Committee on Health Research in 2003- 2011, as member for National Bioethic Committee in 2005-2013, as Chairman for Indonesia Medical Institution Association 2007-2009, as member of National Resaerch Council 2008-2011, as Chairman of Indonesia Medical Colloqium 2009-2012 and as Coordinator of Health Professional Education Quality 2010-2014.

Prof. Yusuf was then appointed as Vice Dean for Academic and Research at the Faculty of Medicine in 2002-2006, which subsequently being elected as Dean for Fac. of Medicine for two terms between 2006-2014. He was the Head of Steering Committee of Novartis- Eijkman Hasanuddin Clinical Research Initiative (NECHRI) 2008-2014, an initiative which later on become the seed for the establishmen of Hasanuddin University Medical Reserach Center (HUMRC) at Hasanuddin University since 2014.

He has been a member of Medical Commission of The Indonesian Academy of Sciences (AIPI) since 2008. Prof Irawan Yusuf revived his passion back on research, among them is collaboration with Japanese scientists on the investigation of genetic and social behavior (individualism vs. Collectivism). He was a Visiting Professor at Kyoto University in 2015.

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Professor CA Nidom Airlangga University, Surabaya Job title: Chairman - Avian Influenza Research Center (AIRC)

Email: [email protected]

Prof. Nidom is a molecular biologist, virologist, vaccinologist, and also the Chairman of Avian Influenza Research Centre (AIRC) Universitas Airlangga. He specializes on Avian Influenza (H5N1) and has been active in Avian Influenza research since 2003 until now. In line with this, he also conducted various studies on HIV / AIDS, Ebola, Zika viruses, malaria, TB and emerging and re-emerging infectious diseases in Indonesia.

Prof. Nidom is an active member of various local and international organization, consortium, and scientific panel on Avian Influenza Control and Pandemic Influenza Preparedness, The National Committee for Emerging and Reemerging Infectious Diseases - Ministry of Health Indonesia (PINERE), biorisk and biosafety, and molecular biology network.

Various research collaboration has also been done; including Tokyo University (Japan), Hokkaido University (Japan), University of Laussane (Swiss), University of Geneva (Swiss), University of Wisconsin, PT. Biofarma (Indonesia) and various government institutions in Indonesia. The Collaborative researches currently being done are “Evaluation of the pandemic potential of H5N1 highly pathogenic avian influenza viruses circulating in Indonesia” funded by the e-ASIA Joint Research Program (e-ASIA JRP) FY: 2016 – 2019, “Innovative adjuvanted influenza vaccines: a Swiss-Indonesia collaboration towards better pandemic influenza preparedness’ funded by Swiss National Science Foundation. (FNSNF) FY 2016-2019, and :”Neurovirulence Test of Bulk nOPV2 in Animal BSL-3 AIRC Universitas Airlangga” funded by PT. Bio Farma (Persero) Bandung FY 2016- 2017.

Many national and international scientific publications have resulted from the research, among others, as many as 25 international publications journal regarding Avian Influenza, Ebola and many national publications, including research of malaria. In addition, he is also active as a speaker at various scientific forums both nationally and internationally.

Now, he and researchers from AIRC – Universitas Airlangga have been performing a research proposal in Maluku island with title ““Mapping on Strategic Diseases in The archipelago at Eastern Regions of Indonesia As One Preventive Barrier Effort for Spreading of Communicable Diseases, Neglected Tropical Diseases (NTDs) and Unknown Diseases into the Pacific Territory. A Model Study of Human - Animal –Environment- Interface”

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Professor Adi Utarini Gadjah Mada University, Yogyakarta Job title: Vice Dean - Faculty of Medicine

Email: [email protected]

Prof Adi is currently the Vice Dean for Research, community service and collaboration at the Faculty of Medicine, Universitas Gadjah Mada and also the Project Leader for Eliminate Dengue Project-Yogyakarta (EDP-Yogya). She obtained her Master‘s degree from the Institute of Child Health, London UK and continued her PhD in the Department of Public Health and Epidemiology, Umea University Sweden.

In relation to research and collaboration, her role is to identify possibilities to broaden engagement and networking with other institutions across the globe in order to find the link and match with researchers within the Faculty of Medicine, as well as to continuously improve laboratory facilities and research management system to create a better atmosphere for the researchers to perform their activities. She will represent the Faculty of Medicine’s interest at the UK-Indonesia Joint Health Research Call workshop in Jakarta.

Research activities in the faculty are supported by nine research centres, laboratories and departments, and for the last five years, the amount of research funding managed by the Faculty was nearly tenfold, predominantly, from international funding. The two largest research centers are the Centre for Health Policy and Management and the Centre for Tropical Medicine, of which she also plays an active role.

At the department level, the largest research is conducted by the Paediatric Research Office (PRO). In the workshop, current research networking with UK and highlights of the main research in the area of infectious diseases such as in vaccine development, vector control intervention and few other areas of interests. Internationally recognized capacity building activities are also present in the Faculty, such as being the WHO-TDR Regional Training Centre for the following: Tuberculosis, Good Clinical Practice, Good Clinical Laboratory Practice, Good Health Research Practice.

In addition to the managerial position, she is also an active researcher in the Department of Health Policy and Management. Her areas of expertise include quality management with particular interest in infectious disease management, public-private partnership in the implementation of DOTS strategy, and evaluation of health programmes. Her current research project is applying Wolbachia Aedes aegypti intervention to reduce dengue cases in Yogyakarta, funded by Tahija Foundation, Indonesia. This initiative is part of the Eliminate Dengue Project-Global (EDP-Global), led by Monash University, Australia. EDP- Global is currently implemented in Australia, Vietnam, Indonesia, Brazil and Colombia. More information about EDP can be found at: www.eliminatedengue.or.id (EDP-Yogya) and www.eliminatedengue.com (EDP-Global).

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Professor Yati Soenarto Gadjah Mada University, Yogyakarta Job title: Professor of Pediatrics, Consultant of Pediatric Gastroenterology

Email: [email protected]

Professor Yati Soenarto has been called the mother of modern pediatrics in Indonesia. Since graduating in Medicine from Universitas Gadjah Mada (UGM) Indonesia in 1970, she has pursued a quest to improve the health of the nation’s children and build pediatric capacity in the country’s medical workforce. Her post-graduate training has spanned Indonesia, The Royal Children Hospital Melbourne, Vrije Universiteit Amsterdam, University of Toronto, Harvard Medical School Boston, and she has been Professor of Pediatrics at UGM in Yogyakarta since 2007.

Significant improvements in Indonesian public and pediatric health have been made through Yati Soenarto’s establishment of the Paediatric Research Office (PRO) and chairing the Centre for Clinical Epidemiology and Biostatistics at UGM, and through the generations of Indonesian pediatricians she has taught and mentored for over four decades.

Yati Soenarto’s longstanding relationship with the University of Melbourne began over 40 years ago, collaborating on rotavirus and diarrhea disease management research with Professor Ruth Bishop and Professor Graeme Barnes. Her collaboration now extends across a range of child health research activities involving the Centre for International Child Health and the Royal Children’s Hospital. An important element has been the development of a strong bond based on mutual respect across the institutions. A regular exchange of promising students and young doctors and researchers has occurred including a significant number of PhD and Master students at the Melbourne.

Her work with Professors Bishop and Barnes led to the identification of rotavirus as the chief cause of severe diarrhea throughout the developing world. She has since gone on to introduce a program of oral rehydration for diarrheal disease in Indonesia that is being used as a model in developing countries worldwide, and is chief investigator in a multi- partner clinical, academic and corporate collaboration aimed at manufacturing rotavirus vaccine in Indonesia, collaborated with Bio Farma, a state own company, producing high quality vaccines and antisera since 1980. Eleven vaccines that produce by Bio Farma are WHO pre qualified vaccines were exported in more than 130 countries around the world. Indonesia also has commitment to established vaccine research in Indonesia by organizing the Vaccine Research Forum Annually since 2011 and involved in 13 working groups or consortiums for vaccine and biosimilar development.

With numerous numbers of publications in peer-reviewed journals to her name she has made important contributions in the areas of epidemiology, and in translational research

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into common childhood diseases. She has conducted investigations home fluid solution, local food-based feeding, and zinc therapy for diarrhea led the development of policy on

Diarrheal Disease Control and Integrated Management of Childhood Illness (IMCI) for being introduced in the Curriculum of Indonesian Medical School, and is leading the previous Dengue working with Professor Scott Halstead, and Tuberculosis studies in

Yogyakarta in the early 1980th with her team. She and the UGM team has been working with Dr. Jon E Rohde, a Pediatric consultant, as a representative of the Rockefeller Foundation at UGM, for 7 years of period time, since 1970.

Yati Soenarto has been actively involved in the field of Bioethics and Humanities since 1996, started from Harvard Medical School as a Freeman fellow under the supervision of Professors Mary Jo Good and Byron Good who remain collaborators of the UGM team. Under the Principle Investigator of Professor Soenarto Sastrowijoto on the study of End of Life. As a co-author, a joint study between Harvard and UGM Medical Schools on “End of Life” has been published. Further proposal is being discussed as a follow up action of the earlier study.

Yati Soenarto has made valuable contributions to the work of a wide range of boards, committees and organisations the world over but most particularly throughout Indonesia and Asia and her expertise is sought frequently for presentations at conferences and symposia.

Recognition of Yati Soenarto’s leadership in pediatrics includes the Bakrie Award, the Outstanding Asian Pediatrician Award and the R Sutedjo Award. She got Doctor Honoris Causa of Medical Science on November 2015 by Melbourne Uni for her contributions to the development of paediatrics in Indonesia and the advancement of public pediatric health will benefit generations of children, their families, communities and nations. She also just received (in 2016) : Faculty award. Faculty of Medicine, Universitas Gadjah Mada.

In this very exciting program developed by DIPI-MRC UK Joint Health Research Workshop, she hopes she will be able to meet and to introduce her research team of UGM to distinguished guests from UK, to enable them getting to know each other briefly, which hope to be continued further after that coming workshop.

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Dr Bachti Alisjahbana Padjajaran University, Bandung Job title: Researcher, Faculty of Medicine

Email: [email protected]

Bachti Alisjahbana completed his medical study in the Faculty of Medicine, Universitas Indonesia, Jakarta (1989) and conducted his field duty in the Central Highlands of Papua (1990-1993). Following his residency in Internal Medicine, Medical Faculty, Universitas Padjadjaran (UNPAD), in 1999, he became a staff member of the Department, with a focus on infectious diseases. He has started contributing to research project in the KNAW, SPIN 1 program while achieving his PhD degree which was accomplished in the University Medical Center Nijmegen (2000-2007).

Subsequently, he continues leading many investigators and projects related to TB, HIV and general infectious disease in UNPAD until now. Currently he also holds a position as the chairperson of the TB-HIV research centre, Faculty of Medicine, Universitas Padjadjaran. In the National TB Program, he has a role as the chairperson of the Operational Research Group that promotes implementation of research for improvement of TB Program.

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Professor Din Syafrudin Eijkman Institute Job title: Senior Research Fellow at The Eijkman Institute for Molecular Biology, Jakarta, Indonesia & Professor and Chairman of Parasitology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Email: [email protected]

Syafruddin was trained in medicine and graduated in 1985 at Hasanuddin University, Makassar, Indonesia, and doctoral degree in parasite cell biology in 1992 at Toyama Medical and Pharmaceutical University, Toyama, Japan. He is currently a senior research fellow at the Eijkman Institute for Molecular Biology, Jakarta, and Professor and Chairman of Parasitology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

His interests include several aspects such as: elucidation the role of extrachromosomal DNAs in the assembly of the mitochondrial energy transducing membrane of the malarial parasite, molecular mechanisms underlying Plasmodium resistance to antimalarial drug, molecular taxonomy of the malarial parasite, antimalarial drug discovery and molecular studies on the malaria vector resistance to insecticides. Until recently, he has published more than 70 international peer-reviewed papers and has been awarded several national and international competitive research grants.

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Dr Heni Rachmawati Bandung Institute of Technology, Bandung Job title: Chair – Division of Nanopharmacy

Email: [email protected]

Heni Rachmawati currently chairs the Nanopharmacy division at Bandung Institute of Technology (ITB), National Research Center for Nanoscience and Nanotechnology. She was a formally trained pharmacists with a graduate degree from ITB, a PhD from Groningen University, Netherlands and subsequent post-doctoral degrees from Freie Universitaet Berlin, Germany and National University of Singapore, Singapore.

Her current research interests is on drug delivery system and nanotechnology-based formulation. She holds an Indonesian patent on improved pharmacological effect and pharmacokinetic profile of curcumin through nano processing and production.

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Dr Neni Nuraeny PT Biofarma Job title: Project Integration Manager, Research and Development Division

Email: [email protected]

Neni Nurainy, Ph.D joined Bio Farma in 1998 as Research and Development staff. She is currently a Project Integration Manager of Research and Development Division at PT Bio Farma. She graduated from Bandung Institute of Technology‘s Pharmacy Department in 1996. She continued post graduate study and obtained her Ph.D on Biomedical Science at Faculty of Medicine University of Indonesia in 2005. Her research experience was in Molecular diversity of Hepatitis B Virus (HBV) and its relationship with population background in Indonesia. Her experience in vaccinology was in development of upstream and downstream processing of Haemophilus influenza type b conjugated vaccine and the Hib vaccine now in market as pentavalent vaccine (DTP/HB/Hib) in Indonesia and global market. Her interest in vaccine development let to her becoming a Post Doctoral Research Fellow at Department of Microbiology and Immunology, The University of Melbourne in 2009 and research on DNA vaccine technology and delivery system of vaccine using TLR-2 agonist. Her activities now are developing of therapeutic Hepatitis B vaccine, new TB vaccine, adjuvant and delivery system of antigen and development of therapeutic protein.

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Dr Sitti Wahyuni Hasanuddin University, Makassar Job title: Senior Lecturer - Hasanuddin University Medical Research Center

Email: [email protected]

Sitti Wahyuni graduated from Medical Faculty Hasanuddin University and in 1996 began her carrier as a lecturer in the same university. Following year until 2000 she conducted several epidemiology studies in the field of parasitology and from 2001-2006 she did her PhD at the Department of Parasitology, Leiden University, the Netherlands to study the relationship between helminth infection and allergy. In 2006 she got virology diploma from Pasteur Institute, Hongkong and two years later she spent two months in Gothenburg School of Public Health, Sweden to got her tropical epidemiology diplomas.

Alongside regular curricular teaching, Sitti Wahyuni has placed much emphasis into tropical disease research. From 2007-2014 she investigated epidemiology aspect tuberculosis and dengue infection when she worked as researcher in Novartis-Eijkman- Hasanuddin Clinical Research Initiative (NEHCRI), later became Novartis-Hasanuddin Clinical Research (NHCR), a research collaboration that affiliate to Hasanuddin University which concentrates in tuberculosis and dengue infections. In this collaboration her group reported drug resistant TB in Makassar (first systematic study in Indonesia on drug resistant TB) and the molecular epidemiology of tuberculosis and dengue in Makassar. Beside interested to epidemiology of the disease, Dr. Wahyuni is also studying the immunological response against infectious agent, especially how it affect clinical manifestation when it co-morbid with other disease.

Currently Dr. Wahyuni is coordinating (read: field-coordinator) the university project called ‘The 1000 early days of life: From campus escorts Indonesian generation” In this project each medical student monitor and assist pregnant women, baby born and family (poor family) until the child reached age two years old (approximately 1,000 days from the time of conception). The form of activity is monitoring the development of pregnant women and infants, along with assistance in dealing with health issues related to mother and baby, as well as problem found in the family that could potentially interfere with the growth and development of the pregnant mother and her baby. The project goal is 1) to improve the health status of pregnant women and infants, especially those from poor families and 2) to Increase empathy, knowledge and skills of medical students in dealing with health issues in the community through individual and community approaches. In term of research, the project is opening the opportunity to study many aspect of disease related to mother-child and family transmissions, genetically and environmentally. One example of research that leads by Wahyuni, and now on the track, is a cohort study on pregnant woman to study the influence of mother-microbiome on the immune responses of baby/children.

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Dr Budiman Bela University of Indonesia, Jakarta Job title: Research Coordinator - Institute for Human Virology & Cancer Biology (IHVCB)

Email: [email protected]

Budiman currently coordinates research activities as the Institute for Human Virology & Cancer Biology at University of Indonesia, Jakarta. His research interests is on HIV. For his research on the development of diagnostic system and vaccine of HIV-1, Budiman received a Ministry of Research, Technology and Higher Education grant from 2013- 2016.

Budiman holds a doctorate in biomedical science from University of Indonesia. Aside from academic career, he has also been involved in the Indonesian Ministry of Health’s HIV-AIDS Expert Panel. He is also a member of the ministry’s Anti Microbial Resistance working group, Stem Cell Therapy Guidelines working group and Avian Influenza Diagnostic Network Guidelines working group.

Budiman was also involved in the design and construction for international certification of IHVCB’s BSL2 and BSL3 laboratories.

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Professor Kevin Baird Eijkman – Oxford Clinical Research Institute Job title: Director

Email: [email protected]

Professor Baird earned a B.Sc. in Microbiology and a M.Sc. in Biochemistry from University of Maryland in 1980 and 1983, and a Ph.D. in Medical Zoology from Tulane University School of Public Health and Tropical Medicine in 1994.

He began working on malaria at the Division of Experimental Therapeutics at Walter Reed Army Institute of Research in 1981. Joined the US Navy Medical Service Corps in 1984 and over 22 years served four tours of duty at US Naval Medical Research Unit #2 in Jakarta, Indonesia, along with assignments to Philippines, Ghana, Peru and Washington, DC.

Since 2007 Prof. Baird has directed the Eijkman-Oxford Clinical Research Unit in Jakarta on behalf of Oxford University, where he is Professor of Malariology, Nuffield Department of Medicine. An internationally acknowledge expert on Plasmodium vivax malaria, he serves on several committees, working groups, and review groups at the World Health Organization’s Global Malaria Program.

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Professor George Matthew Mochtar Riady Institute of Nanotechnology, Tangerang Job title: Executive Director

Email: [email protected]

Dr. George Mathew earned his degrees from the Christian Medical College Vellore (undergraduate and post graduate Medical training), undertook post Doctoral Fellowship training in upper GI and Laparoscopic Surgery at the Royal Adelaide Hospital in South Australia.

He continued his postdoctoral research at The University of Adelaide, South Australia; during which time he was awarded the Davis & Geck Prize for the best research paper. His focus of research was on the study of the behavior of malignant cells in the Laparoscopic environment and the role of peritoneal immunity for which he was awarded the Doctorate in Surgery

He was appointed as Professor of Surgery at Christian Medical School in 1997 and then held the position of Head and Professor GI Surgery at Christian Medical College.

He held the position of Vice Dean of the Medical College from 1997 to 2001 and As Dean of the Medical College in charge of all Medical, Allied Health and Research Courses. He was honored with the Best Medical Administrator Award by MGR University for his services to Medical Education and Health Care Delivery. He was also honored with the Mother of Teresa award for Excellence and the Eminent Medical Educationist Award.

He chaired the undergraduate curriculum reform committee of the Medical Council of India.

The main areas of his research interest are Molecular markers in early diagnosis of Gastrointestinal malignancies, marker for metastatic potential in malignant tumors, role of peritoneal immunity, use of virtual reality in medical training and the application of Robotics in Surgery.

Dr. George Mathew joined UPH Medical Science group in October 2011 as the Executive Director of MRIN (Mochtar Riady Institute of Nanotechnology) and the Medical Science Group. His current research involves the study of Hepatitis Virus and its role in the development of Liver cancer, molecular mechanisms in the development of colorectal cancer and chemo prevention of colorectal cancer.

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Professor David H. Muljono Eijkman Institute Job title: Head of Hepatitis Research Laboratory

Email: [email protected]

Professor Muljono is a clinician and academia who also works in the arena of basic biomedical research. He is the Head of the Hepatitis Research Laboratory at the Eijkman Institute for Molecular Biology in Jakarta, and has been carrying out basic and translational researches in viral hepatitis. He is also actively involved in international and national activities targeted to public health in the prevention and control of viral hepatitis and emerging diseases.

Professor Muljono graduated as a medical doctor in 1983 and had his specialist training in Internal Medicine, both completed at Airlangga University, Surabaya, Indonesia, and is now a Fellow title holder of Internal Medicine (equal to FRCP). He was also trained in Hepatology at the University of Sydney in 1989, where he also started his career as a research in hepatitis. In 1998 he secured his PhD in Molecular Medicine at the Jichi Medical School, Tochigi-Tokyo, Japan, and was awarded the Ronpaku Gold Medal by the Japanese Society for the Promotion of Science (JSPS) in 2000 to recognize his discovery of Transfusion-Transmitted Virus (TTV), an non-A-to-G hepatitis virus, and its epidemiology in Indonesia; this achievement was credited by the National Library of Japan.

In addition to his research activities, he also dedicated himself to academic supervision of post graduates (Master and PhD) students in Indonesia and other countries (Italy, the Netherlands, and Denmark). In 2011, he was awarded the title Academy Professor in Life Science by the Royal Netherlands Academy of Arts and Sciences (KNAW) and the Indonesian Academy of Sciences (AIPI), and . On 30 November 2011, and was inaugurated as the Academy Professor Indonesia and subsequently assigned as an endowed a Professor at Hasanuddin University, Makassar, Indonesia. He was also awarded the title Honorary Professor from Sydney Medical School in September 2011. He has been authoring numerous articles on viral hepatitis in scientific, clinical and public health aspects, and also serving as reviewer and editor of several outstanding international journals.

In recognition to his devotion to public health, Professor Muljono received the Ksatria Bakti Husada Kartika award (Distinction Award given by the Indonesian Ministry of Health, Indonesia, 12 November 2011), and Satyalancana Karya Satya XXX (Distinction Award given by the President of Indonesia, in recognition for the devotion to the Community, 17 August 2012). Since 2014, he was assigned as a member of the Strategic and Technical Advisory Committee in Hepatitis (STAC-Hep) to the Director General of the World Health Organization (WHO). He is currently the Chairman of the National Expert Committee for Hepatitis in Indonesia, and serves as the Deputy for Translational Research at the Eijkman Institute for Molecular Biology.

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Dr. Isra Wahid, MD. University of Hasanuddin, Makassar Job Title: Senior Lecturer, Principal Investigator on mosquito and mosquito-borne diseases

Email: [email protected]

Dr. Wahid’s research focused on mosquito dynamic related to the risk of mosquito-borne diseases transmission. His prominent work was a vector control approach base on mosquito dynamic that succeed to reduce dengue incidence in Makassar city from an average 1000 cases/year to be an average 150 cases/year, lower than most other city in Indonesia, and has been maintained for almost 10 years. His innovative mosquito trap design which do not involve human volunteer as attractant but the position of mosquito habitat and village instead, far exceed the performance of WHO standard human landing catch (HLC) method without giving any risk to human to get infective bites in malaria study area.

He was born in Makassar, Indonesia in 1968 and graduated from Medical Faculty of the University of Hasanuddin (UNHAS) of Makassar-Indonesia in 1994. He enjoyed work in the deep of Sulawesi rain forest for three years (1995-1998) as a medical doctor in a PUSKESMAS (Community Health Center) of Aralle, an isolated district with no electricity and vehicles but horses. After completed his duty in Aralle in 1998, he returned to University Hasanuddin as a young lecture at Dept. Parasitology, Faculty of Medicine. A year after, He joined Prof. Motoyoshi Mogi in Saga Medical School, Japan for his PhD, and completed in 2003 in Medical Entomology, then returned to University of Hasanuddin to teach medical parasitology, mostly on mosquito and mosquito-borne diseases from 2003 to date. Joined NEHCRI in 2007, a research collaboration between Novartis Institute for Tropical Diseases – Eijkman Institutes for Molecular Biology and the University of Hasanuddin and that later transformed to HUMRC, the Medical Research Center of Hasanuddin University in 2014 and act as unit head for dengue and other mosquito-borne diseases. While doing his educational and research activities, he took short courses on Virology from the Hongkong Pasteur Institute (2008) and on Advance Mosquito Taxonomy from National Environmental Agency of Singapore and Walter Reed Biosystematic Unit, USA (2011), bio-molecular, statistics and bio-informatics in Novartis Institute for Tropical Diseases, Singapore (2010, 2012), and intestinal parasitology in Tor Vergata University (Rome, 2013). Actively involved in various researches on mosquito and mosquito-borne diseases in Indonesia since then, and received several national and international research grants from Indonesian Ministry of Research and Technology, Bill and Melinda Gates Foundation, UNICEF-Malaria Transmission Consortium (MTC), Notre Dame University and USAID. His research networking include the Sub directorates of Malaria, Arboviruses, and Vector and Reservoirs of Ministry of Health, and the Indonesian Military Health Institute in Jakarta, as well as local institutes in eastern Indonesian region. His research collaboration also include international research institutes from many countries: CDC Atlanta, CDC Colorado, Notre Dame University, Texas University (US); Kitasato University, Okayama University, Nagasaki University (Japan); Novartis Institute for Tropical Diseases (Singapore); and Roma Tre University (Italy); and Chiang Mai University (Thailand).

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He published several scientific papers in national and international peer-reviewed journals on mosquito morphology, behavior and ecology, and mosquito-borne diseases such as malaria and dengue, and now acting as a consultant for the Military Health Institute for Tropical Diseases and as a member of expert panel for vectors, malaria and arboviruses of the Indonesian Ministry of Health.

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Dr Yusuf Alamudi, S.Si, M Kes Universitas Airlangga, Surabayaijkman – Oxford Clinical Research Institute Job title: Researcher

Email: [email protected]

Dr Yusuf Alamudi is a researcher in Avian Influenza Research Center-Universitas Airlangga. He has been conducting research about avian influenza virus since 2006, ranging from detection methods, molecular mechanism of the virus, to its immunogenity for vaccine production.

During his tenure as a researcher, he is also actively enganged in various meetings, seminars, symposia, and conference. Some of the highlight is his participation in International Symposium of Option for the Control of Influenza VI in Toronto, Canada (2007); Bangkok International Conference on Avian Influenza, Bangkok (2008); Asian- African Research Forum on Emerging and Re-Emerging Infection, Hokkaido University- Japan (2008).

Dr. Alamudi was born in Surabaya, East Java in 1980. He received his bachelor degree in biology from Universitas Airlangga, Surabaya in 2003. He then pursued master degree in tropical medicine and received his doctoral degree in medical science in Universitas Airlangga.

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