New Aspects of Clinical Application of Endoscopic Arytenoid Abduction Lateropexy

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New Aspects of Clinical Application of Endoscopic Arytenoid Abduction Lateropexy NEW ASPECTS OF CLINICAL APPLICATION OF ENDOSCOPIC ARYTENOID ABDUCTION LATEROPEXY PhD Thesis Ádám Bach M.D. Department of Oto-Rhino-Laryngology, Head and Neck Surgery University of Szeged University of Szeged, Clinical Medical Sciences Doctoral School PhD Program: Clinical and Experimental Research for Reconstructive and Organ-sparing Surgery Program director: Prof. Lajos Kemény M.D. Supervisor: Prof. László Rovó M.D. Szeged 2018 i PUBLICATIONS RELATED TO THE PhD THESIS I. Bach Á, Sztanó B, Kiss JG, Volk GF, Müller A, Pototschnig C, Rovó L. The role of laryngeal electromyography in the diagnosis of vocal cord movement disorders. [A laryngealis electromyographia szerepe a hangszalag- mozgászavarok diagnosztikájában és az alkalmazott kezelés kiválasztásában] Orv Hetil. 2018;159:303–311. Impact factor: 0,349 II. Bach Á, Sztanó B, Matievics V, Bere Z, Volk GF, Müller A, Förster G, Castellanos PF, Rovó L. Isolated Recovery of Adductor Muscle Function Following Bilateral Recurrent Laryngeal Nerve Injuries. Accepted for publication in The Laryngoscope on 05 November, 2018, DOI: 10.1002/lary.27718 Impact factor: 2,442 III. Rovó L, Bach Á, Sztanó B, Matievics V, Szegesdi I, Castellanos PF. Rotational thyrotracheopexy after cricoidectomy for low-grade laryngeal chrondrosarcoma. Laryngoscope. 2017;127:1109-1115. Impact factor: 2,442 ii CITABLE ABSTRACTS I. Rovó L, Bach Á, Matievics V, Szegesdi I, Castellanos PF, Sztanó B. Reconstruction of the subglottic region in cases of benign and malignant lesions. 4th Congress of European ORL-HNS, October 7-11, 2017, Barcelona, Spain II. Bach Á, Sztanó B, Matievics V, Szegesdi I, Castellanos PF. Adductor reinnervation after recurrent laryngeal nerve injuries – Its clinical importance in bilateral vocal cord paresis. 11th Congress of the European Laryngological Society, 3rd Joint Meeting of ELS- ABEA & ALA, 2nd Meeting of Società Italiana di Laringologia, June 8-11, 2016, Genoa, Italy III. Bach Á, Sztanó B, Nagy A, Matievics V, Szegesdi I, Rovó L. 90° Rotated thyreo-tracheopexy after total and subtotal cricoidectomy - a new surgical method. 3rd Congress of European ORL-HNS, June 7-11, 2015, Prague, Czech Republic IV. Bach Á, Sztanó B, Szakács L, Rovó L. Function preserving solution of a chondrosarcoma of the cricoid cartilage. (PP80) 10th Congress of the European Laryngological Society, April 9-12, 2014, Antalya, Turkey V. Bach Á, Sztanó B, Matievics V, Szakács L, Rovó L. Life quality before and after a reversible glottis enlarging procedure. (PP82) 10th Congress of the European Laryngological Society, April 9-12, 2014, Antalya, Turkey iii VI. Sztanó B, Szakács L, Madani S, Bach Á, Bere Z, Rovó L. Endoscopic arytenoid abduction lateropexy for the treatment of bilateral vocal cord immobility – pediatric application 2nd Congress of CE-ORL-HNS, April 27-30, 2013, Nice, France iv PUBLICATIONS NOT DIRECTLY REALTED TO THE PhD THESIS: I. Matievics V, Sztanó B, Bach Á, Rovó L. Phoniatric outcomes of endoscopic arytenoid abduction lateropexy in patients with transient bilateral vocal cord paralysis. [Endoszkópos arytenoid abdukciós lateropexia foniátriai eredményei átmeneti kétoldali gégebénulás esetén] Orv Hetil. 2018;159:1188-1192. II. Matievics V, Bach Á, Sztanó B, Rovó L. Az endoszkópos arytenoid abdukciós lateropexia foniátriai eredményei nehézlégzéssel járó féloldali gégebénulás esetén. Otorhinolaringologia Hungarica. 2018;64:74-77. III. Matievics V, Bach Á, Sztanó B, Bere Z, Tóbiás Z, Castellanos PF, Müller A, Rovó L. Functional outcomes of endoscopic arytenoid abduction lateropexy for unilateral vocal cord paralysis with dyspnea. Eur Arch Otorhinolaryngol. 2017;274:3703-3710. IV. Madani S, Bach Á, Matievics V, Erdélyi E, Sztanó B, Szegesdi I, Castellanos PF, Rovó L. A new solution for neonatal bilateral vocal cord paralysis: Endoscopic arytenoid abduction lateropexy. Laryngoscope. 2017;127:1608-1614. V. Szakács L, Sztanó B, Matievics V, Bere Z, Bach Á, Castellanos PF, Rovó L. A comparison between transoral glottis-widening techniques for bilateral vocal fold immobility. Laryngoscope. 2015;125:2522-2529. v ABBREVIATIONS BVFI Bilateral Vocal Fold Immobility BVFP Bilateral Vocal Fold Paralysis CRD Complex Repetitive Discharge EAAL Endoscopic Arytenoid Abduction Lateropexy EMG Electromyography ETGI Endolaryngeal Thread Guide Instrument F0 Fundamental frequency HNR Harmonics to Noise Ratio LEMG Laryngeal Electromyography MUAP Motor Unit Action Potential PCA Posterior Cricoarytenoid Muscle PIF Peak Inspiratory Flow PSA Pathological Spontaneous Activity QOL Quality of Life SWAL-QOL Swallowing Quality of Life TA Thyroarytenoid Muscle UDP Ultra Dream Pulse vi CONTENT 1. INTRODUCTION .................................................................................................................. 1 2. ENDOSCOPIC ARYTENOID ABDUCTION LATEROPEXY – BACKGROUND AND SURGICAL TECHNIQUE ........................................................................................................ 3 3. AIMS OF THE THESIS ........................................................................................................ 6 4. INTRODUCTION OF LARYNGEAL ELECTROMYOGRAPHY INTO CLINICAL PRACTICE ................................................................................................................................. 7 4.1. Introduction ..................................................................................................................... 7 4.2. Method ............................................................................................................................. 8 4.2.1. Indications, contraindications ................................................................................... 8 4.2.2. Equipment ................................................................................................................. 9 4.2.3. EMG monitoring ..................................................................................................... 10 4.2.4. Interpretation of LEMG .......................................................................................... 14 5. ISOLATED RECOVERY OF ADDUCTOR MUSCLE FUNCTION FOLLOWING BILATERAL RECURRENT LARYNGEAL NERVE INJURIES ......................................... 17 5.1. Introduction ................................................................................................................... 17 5.2. Materials and methods ................................................................................................... 18 5.2.1. Patients .................................................................................................................... 18 5.2.2. Voice assessment .................................................................................................... 20 5.2.3. Respiratory assessment ........................................................................................... 22 5.2.4. Assessment of vocal fold movement ...................................................................... 22 5.3. Results ........................................................................................................................... 24 5.3.1. Endoscopic results .................................................................................................. 24 5.3.2. Laryngeal electromyography results ....................................................................... 25 5.3.3. Respiratory results .................................................................................................. 26 5.3.4. Voice results ............................................................................................................ 28 6. ENDOSCOPIC ARYTENOID ABDUCTION LATEROPEXY FOR THE COMPLEX RECONSTRUCTION OF THE AIRWAY AFTER TOTAL CRICOIDECTOMY................ 30 6.1. Introduction ................................................................................................................... 30 6.2. Materials and methods ................................................................................................... 31 6.2.1. Patients .................................................................................................................... 31 6.2.2. Surgical technique ................................................................................................... 32 6.2.3. Functional evaluation and follow-up care ............................................................... 37 6.3. Results ........................................................................................................................... 39 vii 7. DISCUSSION ...................................................................................................................... 40 7.1. Introduction of laryngeal electromyography into clinical practice ............................... 40 7.2. Selective recovery of adductor muscle function following recurrent laryngeal nerve injuries .................................................................................................................................. 42 7.3. Endoscopic arytenoid abduction lateropexy for the complex reconstruction of the airway after total cricoidectomy ........................................................................................... 46 8. CONCLUSIONS AND NEW RESULTS ............................................................................ 47 8.1. Introduction of laryngeal electromyography into clinical practice ............................... 47 8.2. Isolated recovery of adductor muscle function following bilateral recurrent laryngeal nerve
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