Identifying Otolaryngology Systematic Review Research Gaps: Comparing Global Burden of Disease 2010 Results with Cochrane Database of Systematic Review Content

Supplementary Online Content

Pederson H, Okland T, Boyers LN, et al. Identifying Otolaryngology Systematic Review Research Gaps: Comparing Global Burden of Disease 2010 Results With Cochrane Database of Systematic Review Content. JAMA Otolaryngol Head Neck Surg. Published online October 30, 2014. doi:10.1001/jamaoto.2014.2700.

eTable 1. GBD 2010 Otolaryngologic Conditions, Their ICD-10 Code Definitions, and Terms Searched on The Cochrane Library eTable 2. Conditions That Comprise Other Hearing Loss Category With Their ICD-10 Code Definitions and Terms Entered into the Search Query eTable 3. Conditions That Comprise Cancer of Other Part of Pharynx and Oropharynx Category With Their ICD-10 Code Definitions and Terms Entered into the Search Query eTable 4. Reviews and Protocols Included for 10 GBD Otolaryngologic Conditions With Their Associated Cochrane Group and Publication Year eTable 5. Excluded Titles Generated From Search of 10 Otolaryngologic Conditions Studied by GBD 2010 in Cochrane Database of Systematic Reviews

This supplementary material has been provided by the authors to give readers additional information about their work.

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 1. GBD 2010 otolaryngologic conditions, their ICD-10 code definitions, and terms searched on The Cochrane Library. Otolaryngologic condition ICD-10 codes Terms entered into search query populating otolaryngologic category in GBD 2010a Esophageal cancer C15-C15.9, D00.1 “malignant neoplasm of oesophagus” “malignant neoplasm of esophagus” “cancer of oesophagus” “cancer of esophagus” “esophageal cancer” “overlapping lesion of oesophagus” “overlapping lesion of esophagus” Otitis media H65-H68, H70 “otitis media” “glue ear” “chronic tubotympanic disease” “chronic atticoantral disease” “Eustachian salpingitis” “obstruction of Eustachian tube” “compression of Eustachian tube” “stenosis of Eustachian tube” “stricture of Eustachian tube” “mastoiditis” “abscess of mastoid” “empyema of mastoid” “caries of mastoid” “fistula of mastoid” “petrositis” Mouth cancer C00-C08 “malignant neoplasm of lip” “cancer of lip” “commissure of lip” “overlapping lesion of lip” “malignant neoplasm of base of tongue” “cancer of base of tongue” “malignant neoplasm of tongue” “cancer of tongue” “malignant neoplasm of lingual tonsil” “cancer of lingual tonsil” “overlapping lesion of tongue” “malignant neoplasm of gum” “cancer of gum” “malignant neoplasm of floor of mouth” “cancer of floor of mouth” “malignant neoplasm of palate” “cancer of palate” “malignant neoplasm of uvula” “cancer of uvula” “overlapping lesion of palate” “malignant neoplasm of mouth”

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 1. GBD 2010 otolaryngologic conditions, their ICD-10 code definitions, and terms searched on The Cochrane Library (continued). “mouth cancer” “overlapping lesion of mouth” “malignant neoplasm of cheek mucosa” “cancer of cheek mucosa” “malignant neoplasm of buccal mucosa” “cancer of buccal mucosa” “malignant neoplasm of buccal sulcus” “cancer of buccal sulcus” “malignant neoplasm of labial sulcus” “cancer of labial sulcus” “malignant neoplasm of retromolar area” “cancer of retromolar area” “malignant neoplasm of oral cavity” “cancer of oral cavity” “malignant neoplasm of parotid gland” “cancer of parotid gland” “malignant neoplasm of submandibular gland” “cancer of submandibular gland” “malignant neoplasm of sublingual gland” “cancer of sublingual gland” “overlapping lesion of major salivary gland” “malignant neoplasm of salivary gland” “cancer of salivary gland” Larynx cancer C32, D02.0, “malignant neoplasm of larynx” D38.0 “cancer of larynx” “malignant neoplasm of glottis” “cancer of glottis” “malignant neoplasm of vocal cord” “cancer of vocal cord” “malignant neoplasm of supraglottis” “cancer of supraglottis” “malignant neoplasm of laryngeal aspect of aryepiglottic fold” “cancer of laryngeal aspect of aryepiglottic fold” “malignant neoplasm of epiglottis” “cancer of epiglottis” “malignant neoplasm of ventricular bands” “cancer of ventricular bands” “malignant neoplasm of subglottis” “cancer of subglottis”

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 1. GBD 2010 otolaryngologic conditions, their ICD-10 code definitions, and terms searched on The Cochrane Library (continued). “malignant neoplasm of laryngeal cartilage” “cancer of laryngeal cartilage” “overlapping lesion of larynx” “carcinoma in situ larynx” “carcinoma in situ epiglottis” “carcinoma in situ laryngeal aspect of aryepiglottic fold” Nasopharynx cancer C11 “malignant neoplasm of nasopharynx” “cancer of nasopharynx” “overlapping lesion of nasopharynx” “malignant neoplasm adenoid” “cancer adenoid” “malignant neoplasm of pharyngeal tonsil” “cancer of pharyngeal tonsil” “malignant neoplasm of fossa of rosenmuller” “cancer of fossa of rosenmuller” “malignant neoplasm of posterior margin of nasal choana” “cancer of posterior margin of nasal choana” “malignant neoplasm of posterior margin of nasal septum” “cancer of posterior margin of nasal septum” Upper respiratory infections J00-J06 “acute nasopharyngitis” “common cold” “acute coryza” “infective nasopharyngitis” “acute rhinitis” “infective rhinitis” “acute sinusitis” “acute abscess of sinus” “acute empyema of sinus” “acute infection of sinus” “acute inflammation of sinus” “acute suppuration of sinus” “acute pansinusitis” “acute pharyngitis” “acute sore throat” “streptococcal pharyngitis” “streptococcal sore throat” “acute tonsillitis” “streptococcal tonsillitis” “acute laryngitis” “acute tracheitis” “acute laryngotracheitis” “acute obstructive laryngitis” eTable 1. GBD 2010 otolaryngologic conditions, their ICD-10 code definitions, and terms searched on The Cochrane Library (continued).

Downloaded From: https://jamanetwork.com/ on 10/02/2021 “croup” “epiglottitis” “acute upper respiratory infection” “acute laryngopharyngitis” “acute upper respiratory disease” Thyroid cancer C73, D44.0 “malignant neoplasm of thyroid gland” “cancer of thyroid gland” “thyroid cancer” “neoplasm thyroid” Cleft lip and cleft palate Q35-Q37 “cleft palate” “fissure of palate” “palatoschisis” “cleft uvula” “cleft lip” “cheiloschisis” “congenital fissure of lip” “harelip” “labium leporinum” a Specific ICD-10 codes used by GBD 2010 are published in: Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Supplementary appendix to: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012; 380: 2095– 2128.

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 2. Conditions that comprise other hearing loss category with their ICD-10 code definitions and terms entered into the search query. Conditions comprising GBD ICD-10 codes that define Terms entered into search other hearing loss category other hearing loss categorya query Conductive and sensorineural H90 “congenital deafness” hearing loss Conductive hearing loss, H90.0 “bilateral conductive hearing bilateral loss” Conductive hearing loss, H90.1 “unilateral conductive hearing unilateral with unrestricted loss” hearing on contralateral side Conductive hearing loss, H90.2 “conductive hearing loss” unspecified Sensorineural hearing loss, H90.3 “bilateral sensorineural bilateral hearing loss” Sensorineural hearing loss, H90.4 “unilateral sensorineural unilateral with unrestricted hearing loss” hearing on contralateral side Sensorineural hearing loss, H90.5 “sensorineural hearing loss” unspecified “congenital deafness” “central hearing loss” “neural hearing loss” “perceptive hearing loss” “sensory hearing loss” “sensorineural deafness” Mixed conductive and H90.6 “bilateral mixed conductive sensorineural hearing loss, and sensorineural hearing bilateral loss” Mixed conductive and H90.7 “unilateral mixed conductive sensorineural hearing loss, and sensorineural hearing unilateral with unrestricted loss” hearing on contralateral side Mixed conductive and H90.8 “mixed conductive and sensorineural hearing loss, sensorineural hearing loss” unspecified Other hearing loss H91 “other hearing loss” Ototoxic hearing loss H91.0 “ototoxic hearing loss” Presbycusis H91.1 “presbycusis” “presbyacusia” Sudden idiopathic hearing loss H91.2 “sudden idiopathic hearing loss” “sudden hearing loss” Deaf mutism, not elsewhere H91.3 “deaf mutism” classified Other specified hearing loss H91.8 “other specified hearing loss” Hearing loss, unspecified H91.9 “unspecified hearing loss” “high frequency deafness” “low frequency deafness” a Specific ICD-10 and ICD-9 codes used by GBD 2010 for the other hearing loss category are published in: Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Supplementary appendix to: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012;380:2095–2128.

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 3. Conditions that comprise cancer of other part of pharynx and oropharynx category with their ICD-10 code definitions and terms entered into the search query. Conditions comprising GBD ICD-10 codes that define Terms entered into search cancer of other part of cancer of other part of query pharynx and oropharynx pharynx and oropharynx category categorya Malignant neoplasm of tonsil C09 “malignant neoplasm of tonsil” “cancer of tonsil” Malignant neoplasm of C09.0 “malignant neoplasm of tonsillar fossa tonsillar fossa” “cancer of tonsillar fossa” Malignant neoplasm of C09.1 “malignant neoplasm of tonsillar pillar tonsillar pillar” “cancer of tonsillar pillar” Overlapping lesion of tonsil C09.8 “overlapping lesion of tonsil” Malignant neoplasm of tonsil, C09.9 “malignant neoplasm of faucial unspecified tonsil” “cancer of faucil tonsil” “malignant neoplasm of palatine tonsil” “cancer of palatine tonsil” Malignant neoplasm of C10 “malignant neoplasm of oropharynx oropharynx” “cancer of oropharynx” Malignant neoplasm of C10.0 “malignant neoplasm of vallecula vallecula” “cancer of vallecula” Malignant neoplasm of C10.1 “malignant neoplasm of anterior surface of epiglottis anterior surface of epiglottis” “cancer of anterior surface of epiglottis” “malignant neoplasm of free border of epiglottis” “cancer of free border of epiglottis” “malignant neoplasm of glossoepiglottic fold” “cancer of glossoepiglottic fold” Malignant neoplasm of lateral C10.2 “malignant neoplasm of lateral wall of oropharynx wall of oropharynx” “cancer of lateral wall of oropharynx” Malignant neoplasm of C10.3 “malignant neoplasm of posterior wall of oropharynx posterior wall of oropharynx” “cancer of posterior wall of oropharynx” Malignant neoplasm of C10.4 “malignant neoplasm of branchial cleft branchial cleft” “cancer of branchial cleft” Overlapping lesion of C10.8 “overlapping lesion of oropharynx oropharynx”

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 3. Conditions that comprise cancer of other part of pharynx and oropharynx category with their ICD-10 code definitions and terms entered into the search query (continued). Conditions comprising GBD ICD-10 codes that define Terms entered into search cancer of other part of cancer of other part of query pharynx and oropharynx pharynx and oropharynx category categorya Malignant neoplasm of C10.9 “malignant neoplasm of oropharynx, unspecified oropharynx” “cancer of oropharynx” Malignant neoplasm of piriform C12 “malignant neoplasm of sinus piriform sinus” “cancer of piriform sinus” “malignant neoplasm of piriform fossa” “cancer of piriform fossa” Malignant neoplasm of C13 “malignant neoplasm of hypopharynx hypopharynx” “cancer of hypopharynx” Malignant neoplasm of C13.0 “malignant neoplasm of postcricoid region postcricoid region” “cancer of postcricoid region” Malignant neoplasm of C13.1 “malignant neoplasm of aryepiglottic fold, aryepiglottic fold hypopharyngeal aspect hypophayngeal aspect” “cancer of aryepiglottic fold hypopharyngeal aspect” “malignant neoplasm of aryepiglottic fold marginal zone” “cancer of aryepiglottic fold marginal zone” Malignant neoplasm of C13.2 “malignant neoplasm of posterior wall of hypopharynx posterior wall of hypopharynx” “cancer of posterior wall of hypopharynx” Overlapping lesion of C13.8 “overlapping lesion of hypopharynx hypopharynx” Malignant neoplasm of C13.9 “malignant neoplasm of hypopharynx, unspecified hypopharyngeal wall” “cancer of hypopharyngeal wall” a Specific ICD-10 and ICD-9 codes used by GBD 2010 for the other hearing loss category are published in: Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Supplementary appendix to: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012;380:2095–2128.

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 4. Reviews and protocols included for 10 GBD otolaryngologic conditions with their associated Cochrane Group and publication year. Otolaryngologic Title of review or Review (R) Publication Cochrane group condition protocol or protocol year (P) Other hearing Steroids for idiopathic R 2013 Ear, Nose and loss sudden sensorineural Throat Disorders hearing loss Group Vasodilators and R 2009 Ear, Nose and vasoactive substances for Throat Disorders idiopathic sudden Group sensorineural hearing loss Antivirals for idiopathic R 2012 Ear, Nose and sudden sensorineural Throat Disorders hearing loss Group Hyperbaric oxygen for R 2012 Ear, Nose and idiopathic sudden Throat Disorders sensorineural hearing loss Group and tinnitus Antioxidants for idiopathic P 2012 Ear, Nose and sudden sensorineural Throat Disorders hearing loss Group Acupuncture for sudden P 2012 Ear, Nose and idiopathic sensorineural Throat Disorders hearing loss Group Intratympanic P 2009 Ear, Nose and glucocorticoids for sudden Throat Disorders sensorineural hearing loss Group Intratympanic gentamicin R 2011 Ear, Nose and for Meniere's disease or Throat Disorders syndrome Group Esophageal Chemoradiotherapy P 2013 Upper cancer versus Gastrointestinal chemoradiotherapy plus and Pancreatic surgery for esophageal Diseases Group cancer Postoperative P 2012 Upper chemotherapy or Gastrointestinal radiotherapy for and Pancreatic esophageal cancer Diseases Group Screening for R 2012 Upper oesophageal cancer Gastrointestinal and Pancreatic Diseases Group Treatment for Barrett's R 2010 Upper oesophagus Gastrointestinal and Pancreatic Diseases Group

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 4. Reviews and protocols included for 10 GBD otolaryngologic conditions with their associated Cochrane Group and publication year (continued). Otolaryngologic Title of review or Review (R) Publication Cochrane group condition protocol or protocol year (P) Perioperative R 2013 Upper chemo(radio)therapy Gastrointestinal versus primary surgery for and Pancreatic resectable Diseases Group adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus Surgery versus radical R 2012 Upper endotherapies for early Gastrointestinal cancer and high-grade and Pancreatic dysplasia in Barrett's Diseases Group oesophagus Preoperative radiotherapy R 2005 Upper for esophageal carcinoma Gastrointestinal and Pancreatic Diseases Group Omentoplasty for R 2012 Upper esophagogastrostomy Gastrointestinal after esophagectomy and Pancreatic Diseases Group Preoperative R 2006 Upper chemotherapy for Gastrointestinal resectable thoracic and Pancreatic esophageal cancer Diseases Group Chinese herbal medicines R 2009 Upper for esophageal cancer Gastrointestinal and Pancreatic Diseases Group Preoperative radiotherapy P 2000 Upper chemotherapy and Gastrointestinal surgery versus surgery and Pancreatic alone for esophageal Diseases Group cancer Otitis media Adenoidectomy for otitis R 2010 Ear, Nose and media in children Throat Disorders Group Antibiotics for the R 2006 Acute prevention of acute and Respiratory chronic suppurative otitis Infections Group media in children Grommets (ventilation R 2008 Ear, Nose and tubes) for recurrent acute Throat Disorders otitis media in children Group

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 4. Reviews and protocols included for 10 GBD otolaryngologic conditions with their associated Cochrane Group and publication year (continued). Otolaryngologic Title of review or Review (R) Publication Cochrane group condition protocol or protocol year (P) Topical analgesia for R 2006 Acute acute otitis media Respiratory Infections Group Antibiotics for otitis media R 2012 Ear, Nose and with effusion in children Throat Disorders Group Pneumococcal conjugate R 2014 Acute vaccines for preventing Respiratory otitis media Infections Group Interventions for acute R 2010 Ear, Nose and otitis externa Throat Disorders Group Autoinflation for hearing R 2013 Ear, Nose and loss associated with otitis Throat Disorders media with effusion Group Antihistamines and/or R 2011 Ear, Nose and decongestants for otitis Throat Disorders media with effusion Group (OME) in children Short-course antibiotics R 2010 Acute for acute otitis media Respiratory Infections Group Once or twice daily versus R 2013 Acute three times daily Respiratory amoxicillin with or without Infections Group clavulanate for the treatment of acute otitis media Interventions for the R 2013 Ear, Nose and prevention of Throat Disorders postoperative ear Group discharge after insertion of ventilation tubes (grommets) in children Oral or topical nasal R 2011 Ear, Nose and steroids for hearing loss Throat Disorders associated with effusion in Group children Antibiotics for acute otitis R 2013 Acute media in children Respiratory Infections Group Grommets (ventilation R 2010 Ear, Nose and tubes) for hearing loss Throat Disorders associated with otitis Group media with effusion in children

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 4. Reviews and protocols included for 10 GBD otolaryngologic conditions with their associated Cochrane Group and publication year (continued). Otolaryngologic Title of review or Review (R) Publication Cochrane group condition protocol or protocol year (P) Identification of children in R 2007 Ear, Nose and the first four years of life Throat Disorders for early treatment for Group otitis media with effusion Zinc supplements for R 2012 Acute preventing otitis media Respiratory Infections Group Xylitol for preventing R 2011 Acute acute otitis media in Respiratory children up to 12 years of Infections Group age Topical antibiotics without R 2005 Ear, Nose and steroids for chronically Throat Disorders discharging ears with Group underlying eardrum perforations Systemic antibiotics R 2006 Ear, Nose and versus topical treatments Throat Disorders for chronically discharging Group ears with underlying eardrum perforations Antibiotic prophylaxis in R 2004 Ear, Nose and clean and clean- Throat Disorders contaminated ear surgery Group Influenza vaccines for P 2012 Acute preventing acute otitis Respiratory media in infants and Infections Group children Surgery for chronically P 2008 Ear, Nose and discharging ears with Throat Disorders underlying eardrum Group perforations Mouth cancer Interventions for the P 2013 Oral Health treatment of oral and Group oropharyngeal cancers: targeted therapy and immunotherapy Clinical assessment to R 2013 Oral Health screen for the detection of Group oral cavity cancer and potentially malignant disorders in apparently healthy adults

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eTable 4. Reviews and protocols included for 10 GBD otolaryngologic conditions with their associated Cochrane Group and publication year (continued). Otolaryngologic Title of review or protocol Review Publication Cochrane condition (R) or year group protocol (P) Diagnostic tests for oral cancer P 2012 Oral Health and potentially malignant Group disorders in patients presenting with clinically evident lesions Interventions for the treatment R 2011 Oral Health of oral cavity and oropharyngeal Group cancer: chemotherapy Interventions for the treatment R 2011 Oral Health of oral and oropharyngeal Group cancers: surgical treatment Interventions for the treatment R 2010 Oral Health of oral cavity and oropharyngeal Group cancer: radiotherapy Screening programmes for the R 2013 Oral Health early detection and prevention Group of oral cancer Interventions for treating oral R 2006 Oral Health leukoplakia Group Cancer of other De-escalation treatment R 2014 Ear, Nose part of pharynx protocols for human and Throat and oropharynx papillomavirus-associated Disorders oropharyngeal squamous cell Group carcinoma Minimally invasive surgery P 2014 Ear, Nose versus and Throat radiotherapy/chemoradiotherapy Disorders for early-stage oropharyngeal Group carcinoma Sentinel lymph node biopsy for P 2012 Ear, Nose the diagnosis of lymph node and Throat involvement in Disorders oral/oropharyngeal squamous Group cell carcinoma Larynx cancer Radiotherapy versus open R 2002 Ear, Nose surgery versus endolaryngeal and Throat surgery (with or without laser) Disorders for early laryngeal squamous Group cell cancer Nasopharynx Chemotherapy as an adjunct to R 2006 Ear, Nose cancer radiotherapy in locally advanced and Throat nasopharyngeal carcinoma Disorders Group Screening for nasopharyngeal P 2010 Ear, Nose carcinoma and Throat Disorders Group

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 4. Reviews and protocols included for 10 GBD otolaryngologic conditions with their associated Cochrane Group and publication year (continued). Otolaryngologic Title of review or protocol Review Publication Cochrane condition (R) or year group protocol (P) Induction chemotherapy P 2013 Ear, Nose followed by concurrent and Throat chemoradiotherapy versus Disorders concurrent chemoradiotherapy Group with or without adjuvant chemotherapy for locally advanced nasopharyngeal carcinoma Upper Remediating buildings damaged R 2011 Acute respiratory by dampness and mould for Respiratory infections preventing or reducing Infections respiratory tract symptoms, Group infections and asthma Inhaled steroids for episodic R 2000 Airways viral wheeze of childhood Group Vaccines for the common cold R 2013 Acute Respiratory Infections Group Vitamin C for preventing and R 2013 Acute treating the common cold Respiratory Infections Group Zinc for the common cold R 2013 Acute Respiratory Infections Group Acetaminophen (paracetamol) R 2013 Acute for the common cold in adults Respiratory Infections Group Heated, humidified air for the R 2013 Acute common cold Respiratory Infections Group Garlic for the common cold R 2012 Acute Respiratory Infections Group Intranasal ipratropium bromide R 2013 Acute for the common cold Respiratory Infections Group

eTable 4. Reviews and protocols included for 10 GBD otolaryngologic conditions with their associated Cochrane Group and publication year (continued).

Downloaded From: https://jamanetwork.com/ on 10/02/2021 Otolaryngologic Title of review or protocol Review Publication Cochrane condition (R) or year group protocol (P) Non-steroidal anti-inflammatory R 2013 Acute drugs for the common cold Respiratory Infections Group Antibiotics for the common cold R 2013 Acute and acute purulent rhinitis Respiratory Infections Group Oral antihistamine- R 2012 Acute decongestant-analgesic Respiratory combinations for the common Infections cold Group Echinacea for preventing and R 2014 Acute treating the common cold Respiratory Infections Group Chinese medicinal herbs for the R 2007 Acute common cold Respiratory Infections Group Corticosteroids for the common R 2012 Acute cold Respiratory Infections Group Saline nasal irrigation for acute R 2010 Acute upper respiratory infections Respiratory Infections Group Antihistamines for the common P 2011 Acute cold Respiratory Infections Group Pelargonium sidoides extract for R 2013 Acute treating acute respiratory tract Respiratory infections Infections Group Nasal decongestants for the P 2012 Acute common cold Respiratory Infections Group Probiotics for preventing acute R 2011 Acute upper respiratory tract infections Respiratory Infections Group

Downloaded From: https://jamanetwork.com/ on 10/02/2021 protocol (P) Advising patients to increase R 2011 Acute fluid intake for treating acute Respiratory respiratory infections Infections Group Decongestants, antihistamines R 2012 Acute and nasal irrigation for acute Respiratory sinusitis in children Infections Group Antibiotics for acute maxillary R 2014 Acute sinusitis in adults Respiratory Infections Group Systemic corticosteroids for R 2014 Acute acute sinusitis Respiratory Infections Group Intranasal steroids for acute R 2013 Acute sinusitis Respiratory Infections Group Antibiotics for clinically R 2012 Acute diagnosed acute rhinosinusitis Respiratory in adults Infections Group Antibiotics for sore throat R 2013 Acute Respiratory Infections Group Short-term late-generation R 2012 Acute antibiotics versus longer term Respiratory penicillin for acute streptococcal Infections pharyngitis in children Group Tonsillectomy for periodic fever, R 2010 Ear, Nose aphthous stomatitis, pharyngitis and Throat and cervical adenitis syndrome Disorders (PFAPA) Group Different antibiotic treatments R 2013 Acute for group A streptococcal Respiratory pharyngitis Infections Group Chinese medicinal herbs for R 2012 Acute sore throat Respiratory Infections Group

Downloaded From: https://jamanetwork.com/ on 10/02/2021 Tonsillectomy or adeno- R 2009 Ear, Nose tonsillectomy versus non- and Throat surgical treatment for Disorders chronic/recurrent acute tonsillitis Group Rapid antigen detection test for P 2013 Acute group A streptococcus in Respiratory children with pharyngitis Infections Group Lidocaine for preventing R 2009 Anaesthesia postoperative sore throat Group Corticosteroids as standalone or R 2012 Acute add-on treatment for sore throat Respiratory Infections Group Delayed antibiotics for R 2013 Acute respiratory infections Respiratory Infections Group Capsaicin for non-allergic P 2013 Ear, Nose rhinitis and Throat Disorders Group Intranasal corticosteroids for P 2013 Ear, Nose non-allergic rhinitis and Throat Disorders Group Antibiotics for acute laryngitis in R 2013 Acute adults Respiratory Infections Group Oral rinses, mouthwashes and R 2013 Ear, Nose sprays for improving recovery and Throat following tonsillectomy Disorders Group Heliox for croup in children R 2013 Acute Respiratory Infections Group Nebulized epinephrine for croup R 2013 Acute in children Respiratory Infections Group Glucocorticoids for croup R 2011 Acute Respiratory Infections Group eTable 4. Reviews and protocols included for 10 GBD otolaryngologic conditions with their associated Cochrane Group and publication year (continued). Otolaryngologic Title of review or protocol Review Publication Cochrane condition (R) or year group protocol (P) Acetylcysteine and R 2013 Acute carbocysteine for acute upper Respiratory © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/02/2021 and lower respiratory tract Infections infections in paediatric patients Group without chronic broncho- pulmonary disease Antibiotics for preventing R 2014 Acute suppurative complications from Respiratory undifferentiated acute Infections respiratory infections in children Group under five years of age Over-the-counter (OTC) R 2012 Acute medications for acute cough in Respiratory children and adults in Infections ambulatory settings Group Thyroid cancer Recombinant human thyrotropin R 2010 Metabolic and (rhTSH) aided radioiodine Endocrine treatment for residual or Disorders metastatic differentiated thryoid Group cancer Amifostine for salivary glands in R 2009 Metabolic and high-dose radioactive iodine Endocrine treated differentiated thyroid Disorders cancer Group Radioiodine therapy for R 2009 Metabolic and differentiated thyroid carcinoma Endocrine with thyroglobulin positive and Disorders radioactive iodine negative Group metastases R 2010 Metabolic and Endocrine Angiogenesis-inhibitors for Disorders metastatic thyroid cancer Group P 2012 Metabolic and Calcitonin testing for detection Endocrine of medullary thyroid cancer in Disorders patients with thyroid nodules Group Low- versus high-dose of P 2010 Metabolic and radioiodine for thyroid remnant Endocrine ablation in differentiated thyroid Disorders carcinoma Group Cleft lip and cleft Infraorbital nerve block for P 2014 Pain, palate postoperative pain following Palliative and cleft lip repair in children Supporative Care Group

Downloaded From: https://jamanetwork.com/ on 10/02/2021 or cleft lip and palate Secondary bone grafting for R 2011 Oral Health alveolar cleft in children with Group cleft lip or cleft lip and cleft palate Interventions for the R 2008 Oral Health management of submucous Group cleft palate Electropalatography for R 2009 Developmental, articulation disorders Psychosocial associated with cleft palate and Learning Problems Group Pre-surgical orthopaedics P 2010 Oral Health (PSO) for infants with Group complete cleft lip and palate Maxillary distraction P 2013 Oral Health osteogenesis versus Group orthognathic surgery for cleft lip and palate patients

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eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews. Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Other hearing loss N/A N/A Esophageal cancer Combined chemotherapy and R radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus Chemotherapy for metastatic R carcinoma of the esophagus and gastro-esophageal junction Medical treatments in the short R term management of reflux oesophagitis Otitis media Interventions for chronic R suppurative otitis media Adenoidectomy for recurrent R or chronic nasal symptoms in children Decongestants and R antihistamines for acute otitis media in children Delayed antibiotics for R respiratory infections Antibiotics for preventing R complications in children with measles Neuraminidase inhibitors for R preventing and treating influenza in children (published trials only) Interventions for ear discharge R associated with grommets (ventilation tubes) Interventions to improve R antibiotic prescribing practices in ambulatory care Immunostimulating agents for P the prevention of acute otitis media Antibiotics for sore throat R Pneumococcal vaccine for R asthma Antenatal breastfeeding R education for increasing breastfeeding duration Vaccines for preventing R influenza in healthy children

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Interventions for atrophic R rhinitis Corticosteroids for the R common cold Pneumococcal vaccination R during pregnancy for preventing infant infection Antibiotics for preventing R suppurative complications from undifferentiated acute respiratory infections in children under five years of age Mouth cancer Interventions for the R prevention and treatment of herpes simplex virus in patients being treated for cancer Surgical interventions for high- R grade vulval intraepithelial neoplasia Topical interventions for R genital lichen sclerosus Pre-operative biliary drainage R for obstructive jaundice Antiepileptic drugs for R preventing seizures in people with brain tumors Interventions for the R management of dry mouth: topical therapies Interventions for smokeless R tobacco use cessation Interventions for smokeless R tobacco cessation in the dental setting Electro-coagulation for liver R metastases Interventions for treating oral R mucositis for patients with cancer receiving treatment Short versus long duration R infusions of paclitaxel for any advanced adenocarcinoma High-dose chemotherapy for R children and young adults with stage IV rhabdomyosarcoma

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Oral morphine for cancer pain R Interventions for preventing R oral candidiasis for patients with cancer receiving treatment Dental extractions prior to R radiotherapy to the jaws for reducing post-radiotherapy dental complications Targeting therapy for R advanced renal cell carcinoma DNA-repair pathway inhibitors R for the treatment of ovarian cancer Chinese medicinal herbs to R treat side-effects of chemotherapy in breast cancer patients Opioids for the management R of breakthrough pain in cancer patients Amifostine for salivary glands R in high-dose radioactive iodine treated differentiated thyroid cancer Chinese medicinal herbs for R chemotherapy side effects in colorectal cancer patients Megestrol acetate for R treatment of anorexia- cachexia syndrome Antiemetic medication for R prevention and treatment of chemotherpy induced nausea and vomiting in childhood Radiotherapy versus open R surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer Comparative efficacy of R epidural, subarachnoid, and intracerebroventricular opioids in patients with pain due to cancer Methadone for cancer pain R

Downloaded From: https://jamanetwork.com/ on 10/02/2021 eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Interventions for the R management of dry mouth: non-pharmacological interventions Non-steroidal anti- R inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia Interventions for replacing R missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants Interventions for treating oral R candidiasis for patients with cancer receiving treatment Transdermal fentanyl for R cancer pain Surveillance of gastric R intestinal metaplasia for the prevention of gastric cancer Central venous access sites R for the prevention of venous thrombosis, stenosis and infection Pre-operative biliary drainage R for obstructive jaundice Tumor necrosis factor-alpha R antibody for maintenance of remission in Crohn's disease Interventions for replacing R missing teeth: dental implants in zygomatic bone for the rehabilitation of the severely deficient edentulous maxilla Cancer of other part of Hyperfractionated or R pharynx or oropharynx accelerated radiotherapy for head and neck cancer Larynx cancer Hyperfractionated or R accelerated radiotherapy for head and neck cancer Nasopharynx cancer N/A N/A

Downloaded From: https://jamanetwork.com/ on 10/02/2021 Upper respiratory infections Maternal dietary antigen R avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child Clinical symptoms and signs R for the diagnosis of Mycoplasma pneumoniae in children and adolescents with community-acquired pneumonia Pharmacological interventions R for hypertension in children Atypical antipsychotics for R aggression and psychosis in Alzheimer's disease Chinese herbal medicine R Huangqi type formulations for nephrotic syndrome Biologics for rheumatoid R arthritis: an overview of Cochrane reviews Abatacept for rheumatoid R arthritis Corticosteroids for pneumonia R Combined corticosteroid and R long-acting beta2-agonist in one inhaler versus long-acting beta2-agonists for chronic obstructive pulmonary disease Chinese medicinal herbs for R mumps Golimumab for rheumatoid R arthritis Cannabinoid type 1 receptor R antagonists for smoking cessation High-flow nasal cannula R therapy for infants with bronchiolitis Rituximab for relapsing- R remitting multiple sclerosis Vaccines for prophylaxis of R viral infections in patients with hematological malignancies Bronchoscopy-guided R antimicrobial therapy for cystic fibrosis eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Rituximab for relapsing- R

Downloaded From: https://jamanetwork.com/ on 10/02/2021 remitting multiple sclerosis Oral 5-aminosalicylic acid for R maintenance of remission in ulcerative colitis Teriflunomide for multiple R sclerosis Certolizumab pegol (CDP870) R for rheumatoid arthritis in adults Antivirals for the common cold R Nasal decongestants for the R common cold Antihistamines for the R common cold Delayed antibiotics for R respiratory infections Superficial heat or cold for low R back pain Local cooling for relieving pain R from perineal trauma sustained during childbirth Thermotherapy for treatment R of osteoarthritis Ginseng for preventing and P treating the common cold Remediating building R damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma Selenium supplementation for R Hashimoto's thyroiditis Treatments for breast R engorgement during lactation Cryotherapy following total R knee replacement Methotrexate for maintenance R of remission in Crohn's disease Calcium channel blockers for R primary Raynaud's phenomenon Dissection versus diathermy R for tonsillectomy

Downloaded From: https://jamanetwork.com/ on 10/02/2021 Rehabilitation following carpal R tunnel release Cryotherapy for hepatocellular R carcinoma Tamsulosin for benign R prostatic hyperplasia Radiofrequency (thermal) R ablation versus no intervention or other interventions for hepatocellular carcinoma Glucocorticoids for acute viral R bronciolitis in infants and young children Epinephrine for bronchiolitis R Combined chiropractic R interventions for low-back pain Interventions for the R management of temperomandibular joint osteoarthritis Combined and alternating R paracetamol and ibuprofen therapy for febrile children Etanercept for the treatment of R rheumatoid arthritis Interventions for clinical and R subclincial hypothyroidism pre- pregnancy and during pregnancy Conservative treatments for R whiplash Non-invasive physical R treatments for chronic/recurrent headache High-flow nasal cannula R therapy for respiratory support in children Cot-nursing versus incubator R care for preterm infants Ketanserin for Raynaud's R phenomenon in progressive systemic sclerosis

eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Interventions to improve R antibiotic therapy prescribing practices in ambulatory care Clinical symptoms and signs R for the diagnosis of Mycoplamsa pneumoniae in

Downloaded From: https://jamanetwork.com/ on 10/02/2021 children and adolescents with community-acquired pneumonia Functional endoscopic sinus R surgery for chronic rhinosinusitis Functional endoscopic balloon R dilation of sinus ostia for chronic rhinosinusitis Topical and systemic R antifungal therapy for the symptomatic treatment of chronic rhinosinusitis Neuraminidase inhibitors for R preventing and treating influenza in healthy adults and children Laquinimod for multiple R sclerosis Deliberate hypotension with R propofol under anaesthesia for functional endoscopic sinus surgery (FESS) Percutaneous endoscopic R gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances Topical steroids for nasal R polyps Nasal saline irrigations for the R symptoms of chronic rhinosinusitis Topical steroid for chronic R rhinosinusitis without polyps Systemic antibiotics for R chronic rhinosinusitis without nasal polyps in adults Noninvasive positive-pressure R ventilation as a weaning strategy for intubated adults with respiratory failure eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Interventions for replacing R missing teeth: augmentation procedures of the maxillary sinus Pneumococcal vaccination R during pregnancy for preventing infant infection

Downloaded From: https://jamanetwork.com/ on 10/02/2021 Coenzyme Q10 for R Parkinson's disease Fluticasone versus R beclomethasone or budesonide for chronic asthma in adults and children Interventions for atrophic R rhinitis Helminth therapy (worms) for R allergic rhinitis Antihistamines used in R addition to topical nasal steroids for intermittent and persistent allergic rhinitis in children Capsaicin for allergic rhinitis in R adults Sublingual immunotherapy for R allergic rhinitis Inferior turbinate surgery for R nasal obstruction in allergic rhinitis after failed medical treatment Topical nasal steroids for R intermittent and persistent allergic rhinitis in children House dust mite avoidance R measures for perennial allergic rhinitis Allergen injection R immunotherapy for seasonal allergic rhinitis Intranasal corticosteroids for R asthma control in people with coexisting asthma and rhinitis Sublingual immunotherapy for R treating allergic conjuctivitis Soy formula for prevention of R allergy and food intolerance in infants

eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Gamma aminobutyric acid R (GABA) receptor agonists for acute stroke Anti-histamines for prolonged R non-specific cough in children Sertindole for schizophrenia R Drug therapy for obstructive R sleep apnoea in adults

Downloaded From: https://jamanetwork.com/ on 10/02/2021 Sildenafil citrate for erectile R dysfunction in patients with multiple sclerosis Formulas containing R hydrolysed protein for prevention of allergy and food intolerance in infants Topical nasal corticosteroids P versus oral antihistamines for allergic rhinitis Chinese herbal medicine for P allergic rhinitis Nasal saline for allergic rhinitis P Allergen injection P immunotherapy for perennial allergic rhinitis Intranasal phototherapy for P allergic rhinitis Acupuncture for allergic rhinitis P Local nasal immunotherapy for P allergic rhinitis Alpha-blocker as medical R expulsive therapy for ureteral stones Maternal dietary antigen R avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child Tartrazine exclusion for R allergic asthma Metrifonate for Alzheimer's R disease Oral H1 antihistamines as R monotherapy for eczema Risperidone versus typical R antipsychotic medication for schizophrenia

eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Adenoidectomy for recurrent R or chronic nasal symptoms in children Antibiotics for preventing P recurrent sore throat Steroids for symptom control R in infectious mononucleosis Antistreptococcal interventions R for guttate and chronic plaque psoriasis

Downloaded From: https://jamanetwork.com/ on 10/02/2021 Supraglottic airway devices R versus tracheal intubation for airway management during general anaesthesia in obese patients Nedocromil sodium versus R cromoglycate for preventing exercise-induced bronchoconstriction Botulinum toxin type A therapy R for cervical dystonia Fluticasone versus placebo for R chronic asthma in adults and children Neuraminidase inhibitors for R preventing and treating influenza in children (published trials only) Immunostimulants for R preventing respiratory tract infection in children Vaccines for preventing R typhoid fever Antibiotics for preventing R complications in children with measles Interventions for guttate R psoriasis Nebulised adrenergic agonists R for acute croup Humidified air inhalation for R treating croup Nebulized racemic R epinephrine for extubation of newborn infants Vitamin A for treating measles R in children

eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Xylitol for preventing acute R otitis media in children up to 12 years of age Pneumococcal conjugate R vaccines for preventing otitis media Antibiotics for acute bronchitis R Antibiotics for acute asthma R Vaccines for preventing R influenza in healthy children Honey for acute cough in R

Downloaded From: https://jamanetwork.com/ on 10/02/2021 children Antibiotics for exacerbations of R chronic obstructive pulmonary disease Corticosteroids for pneumonia R Treatment for Fisher R syndrome, Bickerstaff's brainstem encephalitis and related disorders Chinese medicinal herbs for R measles Thyroid cancer Chinese herbal medicines for R benign thyroid nodules in adults Peginterferon plus ribavirin R versus interferon plus ribavirin for chronic hepatitis C Cleft lip and cleft palate Safety of topical R corticosteroids in pregnancy Effects and safety of R periconceptional folate supplementation for preventing birth defects Antenatal interventions for R reducing weight in obese women for improving pregnancy outcome Surgical interventions for the R early management of Bell's palsy Once or twice daily versus R three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media

eTable 5. Excluded titles generated from search of 10 otolaryngologic conditions studied by GBD 2010 in Cochrane Database of Systematic Reviews (continued). Search otolaryngologic Title of review or protocol Review (R) or protocol (P) condition Antiviral therapy for P symptomatic congenital cytomegalovirus infection in neonates and infants up to 3 months of age

Downloaded From: https://jamanetwork.com/ on 10/02/2021