Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000244235Cyc: Leptospira interrogans UI 09600 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari a dicarboxylate an amino an amino acid cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate ammonium a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid acid

RS211230 RS209125 RS212405 RS217630 RS221825 RS212970 RS217465

cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA ammonium an amino an amino a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA acid acid a dicarboxylate

Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Fatty Acid and Lipid Degradation tRNA processing Macromolecule Modification an sn-glycero-3- (R)-4'- sn-glycero-3- 1498 a [protein]- D-glycero-D- Aminoacyl-tRNA Charging fatty acid β-oxidation I + a uracil a [protein]-L- cob(II)yrinate a,c- a purine a cis- sn-glycerol sn-glycerol γ-L-glutamyl-(S)- sn-glycerol NAD NADPH sn-glycerol sn-glycerol π [2Fe-2S] iron-sulfur cluster biosynthesis superpathway of adenosylcobalamin salvage from cobinamide II flavin biosynthesis I (bacteria and plants) 4-aminobenzoate a palmitoyl-[acp] phospho-N-(acyl) phosphopantothenoyl- phospho-N- gly glycerophosphoserine a protein in 16S rRNA N -phospho- roseoflavin manno-heptose methionine diamide biosynthesis I adenosylcobalamin NAD de novo biosynthesis thiamine salvage II a polycistronic ribonucleoside adenosylcobinamide vaccenoyl-[acp] 3-phosphate 3-phosphate 2-aminobutanoate 3-phosphate 3-phosphate 3-phosphate dITP ATP biosynthesis ethanolamine L-cysteine (arachidonoyl) glycerophosphodiester NAD(P)(+) ATP-dependent Clp 16S rRNA (uracil(1498)- L-histidine 5'-phosphate 7-phosphate peptide- (early cobalt insertion) salvage from cobalamin I (from aspartate) tRNA charging tRNA precursor a (3Z)-alk-3- 5'-triphosphate bifunctional glycerol-3- bifunctional glycerol-3- glycerophosphodiester phosphopantothenoylcysteine bifunctional glutamate- bifunctional glycerol-3- bifunctional glycerol-3- bifunctional glycerol-3- phosphohistidine D-glycero- gln bifunctional ethanolamineglycerophosphoryl diester phosphodiesterase: transhydrogenase (Re/ N(3))-methyltransferase: non-canonical purine bifunctional methionine cob(II)inamide 4-amino-2-methyl-5- glutaminyl-tRNA biosynthesis via transamidation enoyl-CoA phosphate dehydrogenase/ phosphate dehydrogenase/ phosphodiesterase: decarboxylase: -cysteine ligase phosphate dehydrogenase/ phosphate dehydrogenase/ phosphate dehydrogenase/ protease proteolytic phosphatase: beta-D- uroporphyrinogen-III L-cysteine desulfurase chorismate adenosylcobinamide phosphodiesterase: LEP1GSC102_RS222700 Si-specific) subunit alpha: LEP1GSC102_RS221375 NTP pyrophosphatase, riboflavin (S)-S-oxide GTP cob(I)alamin asp pyrimidinemethanol glycerol-3-phosphate glycerol-3-phosphate LEP1GSC102_RS222700 LEP1GSC102_RS213420 GshA/glutathione glycerol-3-phosphate glycerol-3-phosphate glycerol-3-phosphate subunit: clpP LEP1GSC102_RS216880 manno- uroporphyrinogen-III aminodeoxychorismate kinase/adenosylcobinamide- LEP1GSC102_RS224120 glycerophosphoryl diester LEP1GSC102_RS217400 16S rRNA (uracil(1498)- RdgB/HAM1 family: rdgB kinase/FAD reductase: cob(I)yrinic acid bifunctional arg acyltransferase: acyltransferase: glycerophosphoryl diester phosphopantothenoylcysteine synthetase GshB: acyltransferase: acyltransferase: acyltransferase: ATP-dependent Clp phosphohistidine heptose-7- C-methyltransferase: cysteine desulfurase: L-aspartate oxidase: synthase, arginine--tRNA ligase: glu phosphate phosphodiesterase: NAD(P) transhydrogenase: N(3))-methyltransferase: nucleoside triphosphate synthetase: msrA a,c-diamide bifunctional 3,4- hydroxymethylpyrimidine long-chain fatty LEP1GSC102_RS216760 LEP1GSC102_RS216760 phosphodiesterase: decarboxylase: glycerophosphodiester LEP1GSC102_RS210935 LEP1GSC102_RS216760 LEP1GSC102_RS216760 LEP1GSC102_RS216760 protease proteolytic subunit: phosphatase phosphate cobA LEP1GSC102_RS222330 LEP1GSC102_RS219620 component I: pabB LEP1GSC102_RS224960 an L-arginyl- a tRNA precursor a tRNA precursor with a 2,3,4-saturated guanylyltransferase: LEP1GSC102_RS224120 LEP1GSC102_RS224145 LEP1GSC102_RS210745 pyrophosphohydrolase: ribF adenosyltransferase: dihydroxy-2-butanone- cob(II)alamin kinase/ 4-amino-4- coenzyme A acid--CoA ligase: a (2E)-2- [+1- 2cis isozymes]-vaccenoyl- [+ 21-palmitoyl- isozymes] LEP1GSC102_RS224120 LEP1GSC102_RS213415 phosphodiesterase: ophthalmate 1-C16:0-α,ω[+- 2 isozymes] [+ 2 isozymes] 1-oleoyl-sn[+ 2 isozymes] LEP1GSC102_RS225575 an N 3 - SixA: sixA roseoflavin adenine D-glycero-βkinase:-D- rfaE1 peptide- precorrin-1 2-iminosuccinate [tRNA Arg ] with a 5' extension a 5' extension and fatty acid LEP1GSC102_RS212635 1-(18- LEP1GSC102_RS223235 cobO phosphomethylpyrimidine deoxychorismate enoyl-CoA a purine adenosyl- sn-glycerol an N- LEP1GSC102_RS222700 sn-glycerol LEP1GSC102_RS224140 1498 a [protein]- dinucleotide methionine an S-sulfanyl-[L- 4-phosphate synthase/ Arg LEP1GSC102_RS212405 acyl-carrier protein sn-glycerol- acyl-carrier protein sn-glycerol 4'-phosphopantetheine sn-glycerol ser dicarboxyl-2- hydroxyoleoyl) -glycerol 3- a peptide methyluracil manno-heptose cob(I)yrinic acid a tRNA and a long 3' trailer a short 3' extension ribonucleoside cobinamide 3-phosphate acylethanolamine anandamide 3-phosphate + L-histidine dIMP (S)-S-oxide uroporphyrinogen-III cysteine desulfurase] ATP:cob(I)alamin GTP cyclohydrolase II: quinolinate synthase: kinase: thiD [+ 3 isozymes] 3-phosphate 3-phosphate 3-phosphate lysophosphatidate NADP NADH -sn-glycrol phosphate in 16S rRNA 1,7-bisphosphate a,c-diamide acyl-CoA dehydrogenase: a 2,3,4- 5'-diphosphate phosphate reductase: C-methyltransferase: adenosyltransferase: LEP1GSC102_RS218350 LEP1GSC102_RS208905 gln an L-glutamyl- ribonuclease 3-phosphate adenosyltransferase: HMP-P LEP1GSC102_RS223025 saturated (3R)-3- msrA cobA LEP1GSC102_RS207985 Gln P protein 2,5-diamino-6-(5-phospho-D- cobO [tRNA ] [+ 10 isozymes] a 2,3,4- hydroxyacyl-CoA a protein-L- [corrinoid ribosylamino)pyrimidin-4(3H)-one quinolinate bifunctional 5-(2-hydroxyethyl) 4-aminobenzoate imidazole glycerol ribonuclease D: ribonuclease D: component: a 2,3,4-saturated methionine- precorrin-2 an S-sulfanyl-[cysteine cob(II)alamin- Asp-tRNA(Asn) saturated (3S)-3- adenosyltranferase]- bifunctional hydroxymethylpyrimidine -4-methylthiazole cys phosphate synthase cyclase: LEP1GSC102_RS220595 LEP1GSC102_RS223115 rnpA fatty acyl CoA (S)-S-oxide desulfurase]-[disordered- [corrinoid nicotinate- cysteine--tRNA ligase: /Glu-tRNA(Gln) hydroxyacyl-CoA bifunctional precorrin- cob(II)inamide diaminohydroxyphosphoribosylaminopyrimidine kinase/ LEP1GSC102_RS221550 ribonuclease D: ribonuclease D: form scaffold adenosyltranferase] nucleotide hydroxyethylthiazole kinase: LEP1GSC102_RS225225 an L-cysteinyl- amidotransferase Amino Acid Degradation 2 dehydrogenase/ deaminase/5-amino-6-(5-phosphoribosylamino) phosphomethylpyrimidine gatA LEP1GSC102_RS223115 LEP1GSC102_RS220595 a tRNA precursor with protein] complex pyridoxal 5'-phosphate biosynthesis I diphosphorylase LEP1GSC102_RS220485 Cys subunit GatA: gatA undecaprenyl- 1-stearoyl- sn-glycero-3- adenine 1518 / 3-octaprenyl-4- a [DNA]-3'- a 5'-phospho- an [RNA]-3'- a [protein]-α- a [protein]- [tRNA ] [+ 7 isozymes] a short 3' extension sn-glycerol + sn-glycerol τ sirohydrochlorin uracil reductase: LEP1GSC102_RS218340 kinase: thiD Cys a 5-phosphooxy- oleate glycerophosphoglycerol NAD acetyl-CoA (carboxylating) 4-methyl-5-(2- a tRNA diphospho-N- a myristoyl-[acp] a stearoyl-[acp] sn-glycerol phosphoethanolamine adenine 1519 in 16S rRNA hydroxybenzoate hydroxyl [DNA] ribonucleoside- L-glutamate N -phospho- phosphoenol ferrochelatase: [corrinoid L-leucine degradation I ATP cob(II)inamide 3-phosphate 3-phosphate XTP dGDP GMP IMP 5-amino-6-(5-phospho- D-erythrose cob(I)alamin- : nadC phosphooxyethyl) ammonium L-glutamyl- a 2,3,4-saturated a 2,3,4-saturated acetylmuramoyl- UDP-N-acetyl- bifunctional glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- long-chain fatty glycerophosphodiester 16S rRNA (adenine(1518)- glycerophosphoryl diester UbiD family decarboxylase: DNA acetyl-CoA carboxylase bifunctional glycerol-3- 2',3'- protein-glutamate O- L-histidine pyruvate LEP1GSC102_RS224430 adenosyltranferase]- HMP-PP Gln phosphohistidine non-canonical purine pyruvate D-ribosylamino)uracil 4-phosphate [corrinoid thiazole [tRNA ] ribonuclease D: fatty acyl CoA 3-oxoacyl-CoA L-alanyl-γ-D- α-D-glucosamine ATP:cob(I)alamin phosphate dehydrogenase/ phosphate acyltransferase: acid--CoA ligase: phosphodiesterase: N(6)/adenine(1519)-N(6))- phosphodiesterase: LEP1GSC102_RS209045 ligase biotin carboxyl: phosphate dehydrogenase/ cyclophosphate methyltransferase CheR: a [cysteine desulfurase]- cob(I)inamide RNA 2',3'-cyclic phosphatase: NTP pyrophosphatase, kinase: pyk 5'-nucleotidase 5'-nucleotidase bifunctional adenosyltranferase] NaMN superpathway of heme a tRNA precursor LEP1GSC102_RS223115 leu glutamyl-L-lysyl- undecaprenyldiphospho- adenosyltransferase: glycerol-3-phosphate LEP1GSC102_RS215930 LEP1GSC102_RS209125 LEP1GSC102_RS222700 dimethyltransferase RsmA: LEP1GSC102_RS224120 3-polyprenyl-4- (NAD(+)) LEP1GSC102_RS214740 glycerol-3-phosphate LEP1GSC102_RS225150 sirohydrochlorin S-sulfanyl-[disordered- cob(I)yrinic acid Asp-tRNA(Asn) muramoylpentapeptide beta-N- LEP1GSC102_RS207985 phosphodiesterase: LEP1GSC102_RS216880 RdgB/HAM1 family: rdgB pyruvate SurE: surE SurE: surE diaminohydroxyphosphoribosylaminopyrimidine cob(I)yrinic acid thiamine phosphate b biosynthesis from with a 5' extension branched-chain amino D-alanyl-D-alanine acyltransferase: [+ 3 isozymes] glycerophosphoryl diester 6 LEP1GSC102_RS2238401518 glycerophosphodiester hydroxybenzoate LigA: ligA LEP1GSC102_RS214735 acyltransferase: protein-glutamate O- form scaffold a,c-diamide D-ribulose 5-phosphate nicotinate-nicotinamide /Glu-tRNA(Gln) ribonuclease D: ditrans,octacis- [+ 41-stearoyl-2- isozymes] N -dimethyladenine an [RNA]-3'-LEP1GSC102_RS217645 phosphohistidine kinase: pyk synthase: gln acetylglucosaminyltransferase: cob(I)yrinic acid a,c-diamide 6 1519 methyltransferase CheR: nucleoside triphosphate deaminase/5-amino-6-(5-phosphoribosylamino) 4-phospho- a,c-diamide nucleotide uroporphyrinogen-III LEP1GSC102_RS220595 acid transaminase: acetyl-CoA C- undecaprenyldiphospho- LEP1GSC102_RS216760 stearoyl-sn phosphodiesterase: /N -dimethyladenine phosphodiesterase: decarboxylase: acetyl-CoA carboxylase LEP1GSC102_RS216760 protein] complex adenosyltransferase: LEP1GSC102_RS221380 amidotransferase LEP1GSC102_RS210675 adenosyltransferase: cobO acyl-carrier protein diphosphate AMP oleoyl-CoA NMN AMP [DNA] ribunucleoside- LEP1GSC102_RS210640 phosphatase pyrophosphohydrolase: dGTP pyruvate bifunctional 3,4- uracil reductase: LEP1GSC102_RS218340 D-erythronate adenosyltransferase: adenylyltransferase: uroporphyrinogen-III 4-methyl-2-LEP1GSC102_RS217170 acyltransferase: N-acetyl-(N-acetyl-β-D- [+ 2 isozymes] -glycerol 3- LEP1GSC102_RS224120 in 16S rRNA LEP1GSC102_RS222700 LEP1GSC102_RS208335 carboxyltransferase subunit: [+ 2 isozymes] a [protein]-L- guanosine inosine cysteine desulfurase: cobO an L-glutaminyl- subunit GatA: gatA ribonuclease: triphosphate adenosylcobinamide 1-myristoyl- 1-palmitoyl- 2'-phosphate SixA: sixA LEP1GSC102_RS223235 cobO LEP1GSC102_RS210020 UDP sn-glycerol sn-glycerol LEP1GSC102_RS207910 5 a [protein]- dihydroxy-2-butanone- 5-amino-6-(5-phospho- nadD uroporphyrinogen Gln oxopentanoate acetyl-CoA glucosaminyl)muramoyl- acyl-carrier protein sn-glycerol phosphate ethanolamine glycerol 2-octaprenylphenol sn-glycerol glutamate-O cobalt- LEP1GSC102_RS222330 ATP:cob(I)alamin 4-phosphoerythronate thiamine [tRNA ] rnpA 3-phosphate 3-phosphate XMP 4-phosphate synthase/ D-ribitylamino)uracil ATP:cob(I)alamin decarboxylase: Gln L-alanyl-γ-D-glutamyl-L- malonyl-CoA -methyl-ester L-histidine sirohydrochlorin an S-sulfanyl-[cysteine adenosyltransferase: dehydrogenase: nicotinate adenine a tRNA an L-glutaminyl- Pentose Phosphate Pathways 3-phosphate 3-phosphate GTP cyclohydrolase II: adenosyltransferase: phosphate LEP1GSC102_RS212090 lysyl-D-alanyl-D-alanine LEP1GSC102_RS207985 LEP1GSC102_RS218250 dinucleotide [tRNA Gln ] desulfurase]-S- LEP1GSC102_RS218350 LEP1GSC102_RS207985 thiamine- coproporphyrinogen III sulfanyl-[disordered- (3R)-3-hydroxy-2-oxo- NAD+ pentose phosphate pathway adenosylcob(III) monophosphate queuosine biosynthesis form scaffold adenosylcobinamide 1-deoxy-L-glycero- 4 phosphooxybutanoate synthetase, NAD(+) (non-oxidative branch) isovaleryl-CoA an (S-diacyl-sn- a (2R)-2-hydroxy an [amino group carrier a [protein]- a cis,cis- ARP alamin-[corrinoid kinase: thiL an L-1- sn-glycerol an acyl-[acyl- sn-glycerol an L-cysteinyl- sn-glycerol a supercoiled cobalt-factor III protein] complex tetrulose 4-phosphate glutamine synthase: glyceryl)-L-cysteinyl- even numbered a stearoyl-[acp] linoleate GSSH sulfite adenosylcobinamide protein]-C-terminal-γ- met N-phospho- phosphoenol delta21,39-3- roseoflavin adenosylcobinamide 3-phosphoserine/ adenosyltranferase] glu D-ribulose isovaleryl-CoA phosphatidylethanolamine 3-phosphate carrier protein] 3-phosphate ATP H O [tRNA Cys ] 3-phosphate 2'-deoxyadenosine duplex DNA ITP dADP dependent: nadE thiamine preQ an uncharged tRNA [apolipoprotein] straight chain 2,3,4- long-chain fatty rhodanese domain- 2 bifunctional (L-glutamyl)-L-glutamate ATP-dependent L-histidine pyruvate hydroxyC58:2- bifunctional amidohydrolase: phosphohydroxythreonine cob(I)yrinic acid 0 5-phosphate apolipoprotein N- bifunctional glycerol-3- glycerol-3-phosphate acetylglutamate kinase: aminoacyl-tRNA hydrolase: bifunctional glycerol-3- bifunctional glutamate N- diphosphate L-asparagine biosynthesis III (tRNA-dependent) dehydrogenase: long-chain fatty ATPase: adenosine deaminase: phosphohistidine non-canonical purine pyruvate riboflavin LEP1GSC102_RS212640 6,7-dimethyl-8- transaminase: D-glyceraldehyde a,c-diamide nadE protoporphyrinogen IX an L-glutamyl- NADPH-dependent 7- acyltransferase: saturated fatty acid phosphate dehydrogenase/ acid--CoA ligase: acyltransferase: containing protein: adenosylcobinamide LEP1GSC102_RS214595 LEP1GSC102_RS221875 phosphate dehydrogenase/ acetyltransferase/amino- DNA helicase RecQ: [acp] 3-ketoacyl- pyruvate LEP1GSC102_RS223795 acid--CoA ligase: LEP1GSC102_RS222195 LEP1GSC102_RS222750 phosphatase: NTP pyrophosphatase, kinase: pyk kinase/FAD ribityllumazine synthase: LEP1GSC102_RS224020 3-phosphate [tRNA Glu ] cyano-7-deazaguanine LEP1GSC102_RS218240 glycerol-3-phosphate LEP1GSC102_RS209125 LEP1GSC102_RS218880 LEP1GSC102_RS215475 kinase/adenosylcobinamide- glycerol-3-phosphate LEP1GSC102_RS213660 ACP a [cysteine (R)-1-amino-2-propanol adenosyltransferase: + ribulose- ribose 5- acetylglutamate peptidyl-tRNA hydrolase: acid acetyltransferase ArgJ: LEP1GSC102_RS216880 NAD glu 3-methylcrotonyl- LEP1GSC102_RS209125 [+ 4 isozymes] adenosine RdgB/HAM1 family: rdgB pyruvate synthetase: adenosylcobyrate O-2-phosphate LEP1GSC102_RS222010 4-phosphooxy- 1-deoxy-D- cobO protoporphyrinogen a tRNA asp reductase QueF: apolipoprotein N- acyltransferase: [+ 3 isozymes] [+ 2 isozymes] thiosulfate sulfurtransferase: phosphate LEP1GSC102_RS208280 acyltransferase: LEP1GSC102_RS223075 ATP-dependent reductase: desulfurase]-(S- phosphate 3- phosphate CoA a (R)-2-hydroxy even a 1-acyl-sn + an [amino groupkinase: carrier argB phosphohistidine cobalt-precorrin-3 oxidase: hemG LEP1GSC102_RS210825 Alcohol Degradation [+ 3 isozymes] LEP1GSC102_RS215975 H phosphate ADP guanylyltransferase: deaminase: add N-acetyl-L- DNA helicase RecQ: nucleoside triphosphate kinase: pyk a cis,cis-fabG ribF sulfanyl) -[disordered- L-threonine xylulose-5- epimerase: isomerase acyltransferase: numbered straight LEP1GSC102_RS216760 acyl-carrier protein -glycerol 3- protein]-C-terminal- a tRNA Cys cys LEP1GSC102_RS216760 phosphatase 2 adenosylcobalamin preQ methylcrotonoyl-CoA AMP diphosphate linoleoyl-CoA LEP1GSC102_RS212635 pyrophosphohydrolase: dATP pyruvate roseoflavin 1 diphosphate AMP thiosulfate glutathione 2'-deoxyinosine methionine LEP1GSC102_RS208895 delta21,39-3- form scaffold adenosylcobinamide- 6,7-dimethyl-8-(1-D-ribityl)lumazine 4-hydroxythreonine-4- phosphate tetrahydrofolate biosynthesis lipoate salvage II rpe B: rpiB carboxylase subunit beta: LEP1GSC102_RS223180an N-acyl-(S-diacyl- chain 2,3,4-saturated [+ 2 1-stearoyl-isozymes] phosphate γ-(5-phospho-L- 1-arachidinoyl-[+ 2 isozymes] SixA: sixA adenosylcobinamide-GDP protoporphyrin IX glycerol and glycerophosphodiester degradation a 2-acyl-1-lyso- adenosyl-cobinamide a single a [protein]- LEP1GSC102_RS223235 oxo-C58:2-[acp] 5'-phosphate protein] complex phosphate synthase: phosphate dehydrogenase: synthase: tRNA guanosine(34) LEP1GSC102_RS221820 sn-glyceryl)-L- fatty acyl CoA acyl-carrier protein sn-glycerol glutamyl)-L-glutamate sn-glycerol salvage from cobinamide I (7,8-dihydropterin- phosphatidylethanolamine phosphate stranded DNA L-histidine IMP LEP1GSC102_RS212625 riboflavin synthase: LEP1GSC102_RS210135 dxs a [lipoyl-carrier gln transglycosylase Tgt: D-xylulose D-ribose 5- cysteinyl-[lipoprotein] 3-phosphate 3-phosphate 6-yl)methyl 4-aminobenzoate 6 ferrochelatase: ile 3-methylglutaconyl- cobalt-precorrin-4 LEP1GSC102_RS218345 3-amino-1- 1-deoxy-D- protein]-N - isoleucine--tRNA ligase: an L-aspartyl- LEP1GSC102_RS215340 5-phosphate phosphate a glycerophosphodiester hemH Asn cob(II)inamide diphosphate lipoyl-L-lysine [tRNA ] a 7-aminomethyl-7- CoA adenosyl-cobinamide hydroxyacetone xylulose 5- LEP1GSC102_RS218950 an L-isoleucyl- imidazole glycerol glycerol a [cysteine desulfurase]- cob(I)yrinic acid 7,8- 34 riboflavin 1-phosphate 10 Ile deazaguanosine transketolase: phosphate phosphate N -formyl-tetrahydrofolate biosynthesis protoheme [tRNA ] phosphate synthase cyclase: Asp-tRNA(Asn) glycerophosphodiester a mature peptidoglycan core α,ω-9Z- a dolichyl β- 1-arachidinoyl- a [protein]- DNA with adenine:7,8- a cis,cis- a protein-L- [scaffold protein- a,c-diamide dihydropteroate Ile 6-(hydroxymethyl) γ α (R)-lipoate a tRNA /Glu-tRNA(Gln) in tRNA LEP1GSC102_RS213780 (meso-diaminopimelate a sulfurated hydrogen cyanide M-antigen D-mannosyl a [protein] Ser/Thr 2-methylbutanoate cob(II)yrinate gly -L-glutamyl- sn-glycerol -Kdo CTP (S)-NADPHX dihydro-8- methionine- (2Fe-2S)] complex bifunctional 5,6-dimethylbenzimidazole bifunctional adenosyltransferase: LEP1GSC102_RS221550 glycerol kinase: phosphodiesterase: oligosaccharide- octadecenedioate -7,8-dihydropterin ATP repressor LexA L-glutamine GTP GTP H O delta19,37- pyridoxine 5'- bifunctional amidotransferase S-adenosylmethionine:tRNA [+ 2 isozymes] [sulfur carrier] (variant) monomer D-alanine 2 cobalt- riboflavin kinase/ gatA LEP1GSC102_RS222355 LEP1GSC102_RS222700 containing) lytic transglycosylase rhodanese domain- lipid A (E. coli long-chain fatty phosphate dolichyl-phosphate- 2-amino-4-hydroxy-6- acetate- a,c-diamide 3-phosphate 3-deoxy-manno- bifunctional ADP-dependent chemoreceptor glutamine oxoguanine mismatchA/G-specific 3-hydroxy- (R)-S-oxide adenosylcobinamide cobO phosphate synthase: a tetrahydrofolate folylpolyglutamate synthase/ lipoate--protein ligase: heme b biosynthesis I (aerobic) subunit GatA: gatA ribosyltransferase-isomerase: HMG-CoA undecaprenyl bifunctional glutamate- 1-acyl-sn-glycerol-3- ribosome peptide- precorrin-5A nicotinate-nucleotide-- FAD synthetase: ribF [+ 7 isozymes] domain-containing protein: containing protein: K-12 core type) acid--CoA ligase: mannose--protein hydroxymethyldihydropteridine -CoA cob(I)yrinic acid octulosonate NAD(P)H-hydrate LexA repressor: deamidase CheD: adenylate/guanylate adenine C56:2-[acp]3-ketoacyl- kinase/adenosylcobinamide- ATP:cob(I)alamin LEP1GSC102_RS219635 dihydrofolate synthase: LEP1GSC102_RS219240 a 4-phosphooxy- LEP1GSC102_RS211420 D-sedoheptulose D-glyceraldehyde glycerol glycerophosphoryl diester diphosphate O-antigen ligase domain- -cysteine ligase phosphate acyltransferase: small subunit- methionine dimethylbenzimidazole hydroxymethylglutaryl- LEP1GSC102_RS211865 LEP1GSC102_RS215475 (no GlcNAc) LEP1GSC102_RS212405 mannosyltransferase: diphosphokinase: folK ligase: acs a,c-diamide cytidylyltransferase: kdsB dehydratase/NAD(P) LEP1GSC102_RS219370 LEP1GSC102_RS212530 cyclase domain- glycosylase: ACP a [co-chaperone]- phosphate adenosyltransferase: LEP1GSC102_RS208855 L-aspartyl- 34 7-phosphate 3-phosphate kinase: phosphodiesterase: a mature peptidoglycan GshA/glutathione LEP1GSC102_RS215930 (R)-S-oxide phosphoribosyltransferase: FMN uroporphyrinogen-III ammonium an epoxyqueuosine CoA lyase: containing protein: [+ 3 isozymes] (7,8-dihydropterin- adenosyltransferase: 3-deoxy-manno- H-hydrate epimerase: chemoreceptor glutamine containing protein: dependent reductase: guanylyltransferase: LEP1GSC102_RS207985 (lipoyl)adenylate [tRNA Asn ] glpK LEP1GSC102_RS224120 with (L-alanyl-γ-D- a mature peptidoglycan thiosulfate sulfurtransferase: a 3-O-(α-D- LEP1GSC102_RS225695 2-methylbutanoyl- synthetase GshB: a 1-arachidonoyl-[+ 4 isozymes] mutY reductase: [scaffold protein- cobT [corrinoid pyridoxine 7,8-dihydrofolate uroporphyrinogen leu in tRNA LEP1GSC102_RS209960 LEP1GSC102_RS211200 ω-carboxy- a dolichyl 6-yl)methyl AMP diphosphate cobO octulosonate LEP1GSC102_RS218100 cleaved GTPase A: rsgA a cis,cis- LEP1GSC102_RS212635 bifunctional methionine synthase: leucine--tRNA ligase: transaldolase: glutamyl-meso-2,6- strand (non- LEP1GSC102_RS215975 mannosyl)-(Ser/ CoA adenosyl-cob(III) LEP1GSC102_RS210935 2-acyl-sn-glycerol deamidase CheD: LEP1GSC102_RS214455 an apurinic site fabG msrB cobalt- (2Fe-2S)] complex adenosyltranferase]- 5'-phosphate monoglutamate decarboxylase: O-antigen ligase: AMP diphosphate (9Z)-octadec- phosphate diphosphate triphosphate cytidylyltransferase: kdsB repressor LexA [+ 4 isozymes] adenine delta19,37-3- a [protein]-L- riboflavin kinase/ LEP1GSC102_RS212460 lipoate--protein ligase: LEP1GSC102_RS208595 an L-leucyl- Asp-tRNA(Asn) epoxyqueuosine fsa sn-glycerol diaminopimeloyl-D- reducing terminus) thiocyanate an unsulfurated Thr)-[protein] yrinate a,c-diamide norophthalmate 3-phosphate NADPH LEP1GSC102_RS207925 [+ 13 isozymes] within DNA precorrin-5B SSQ1 chaperone: adenosylcobinamide- α cob(II)inamide LEP1GSC102_RS212090 acetoacetate di-trans,octa-cis 9-enoyl-CoA a [protein]-α- + -ribazole 5'-phosphate pyridoxine/ Leu reductase: queG [sulfur carrier] LEP1GSC102_RS210850 CMP-Kdo cyclic-GMP phosphate GDP H oxo-C56:2-[acp] methionine cobalt-precorrin-5B (C(1) GDP FAD synthetase: ribF LEP1GSC102_RS219240 coproporphyrinogen III [tRNA ] /Glu-tRNA(Gln) 3-phosphate alanine) tetrapeptide -undecaprenyl E. coli M LEP1GSC102_RS208560 pyridoxamine Leu LPS L-glutamate a [glycine- a tRNA amidotransferase a queuosine 34 D-erythrose )-methyltransferase: a [chaperone-ATP]- 5'-phosphate F6P diphosphate FAD dihydrofolate reductase: cleavage complex subunit GatA: gatA in tRNA 4-phosphate glycine cleavage LEP1GSC102_RS212685 [co-chaperone]- adenosylcobinamide- [corrinoid oxidase: pdxH a 7,8-dihydrofolate GDP ribazoletransferase: LEP1GSC102_RS222220 H protein] N 6 - transketolase: cobalt- [scaffold protein- adenosyltranferase]- an odd numbered a 2-methyl an [amino group carrier protein]- 6 dihydrofolate reductase: lipoyl-L-lysine a [glycine-cleavage complex dehydro(indole- 1-cis-vaccenoyl-sn- a ribonucleoside a [protein]-N -D- D-glycero-β-D- 5-hydroxybenzimidazole a cis,cis- a cis,cis- LEP1GSC102_RS224485 PLP dihydrofolate reductase: an L-asparaginyl- LEP1GSC102_RS213780 6 16-hydroxypalmitate decanoate γ glutathione (S)-NADHX precorrin-6A (2Fe-2S)] complex 5-methoxybenzimidazolyl cob(I)inamide H protein] N -lipoyl-L-lysine DHAP straight chain branched 2,3,4- C-terminal- -(L-glutamate 5- 3-yl)acetonitrile 3'-dephospho- a tRNA precursor acyl-carrier protein fructosyl-L-lysine delta17,35-3- delta13,25-3- LEP1GSC102_RS220920 glycine cleavage LEP1GSC102_RS222220 protoporphyrinogen IX [tRNA Asn ] [+ 2 isozymes] glycine ATP glycerol-3-phosphate diphosphate manno-heptose ATP ATP dIDP ribotide phosphate adenosylcobamide biosynthesis cob(I)yrinic acid val long-chain fatty 2,3,4-saturated saturated fatty acid long-chain fatty semialdehyde-2-yl)-L-glutamate glutathione S-transferase: CoA 1-acyl-sn-glycerol-3- ribonucleoside- bifunctional ADP-dependent hydroxyC54:2- hydroxyC44:2- serine system protein H: gcvH valine--tRNA ligase: lipoprotein posttranslational modification dehydrogenase long-chain fatty N-acetyl-gamma-glutamyl- ribonuclease D: 1-phosphate alpha-ribazole SSQ1 chaperone ATPase: adenosylcobalamin from adenosylcobinamide-GDP a,c-diamide a 7,8-dihydrofolate a 5-methyltetrahydrofolate dihydrofolate reductase: D-glyceraldehyde acid--CoA ligase: fatty acid long-chain fatty acid--CoA ligase: LEP1GSC102_RS213820 dephospho-CoA kinase: phosphate acyltransferase: diphosphate reductase, NAD(P)H-hydrate fructosamine-3-kinase: D-glycero-beta-D- adenylate/guanylate [acp] 3-ketoacyl- [acp] 3-ketoacyl- hydroxymethyltransferase:glycine glyA cleavage protoporphyrinogen LEP1GSC102_RS216695 glycine cleavage (aminomethyl- Detoxification acid--CoA ligase: phosphate reductase: LEP1GSC102_RS223115 ACP S-malonyltransferase: nucleoside- phosphatase: LEP1GSC102_RS208560 5'-phosphate adenosyltransferase: LEP1GSC102_RS220920 a [lipoyl-carrier an L-valyl- 3-phosphate LEP1GSC102_RS209125 acid--CoA ligase: LEP1GSC102_RS209125 glutathione S-transferase: LEP1GSC102_RS213170 LEP1GSC102_RS215930 adenosylcobalamin- dehydratase/NAD(P) LEP1GSC102_RS216845 manno-heptose cyclase domain- ACP ACP 5-methoxybenzimidazole 6 oxidase: hemG Val a [prolipoprotein]- system protein LEP1GSC102_RS209125 ribonuclease D: LEP1GSC102_RS222860 diphosphate kinase: cobC cobalt- system protein T: gcvT protein]-N - [tRNA ] transferring): gcvP LEP1GSC102_RS209125 LEP1GSC102_RS211235 6 alpha-ribazole nicotinate-nucleotide-- cobO H: gcvH [+ 3 isozymes] [+ 3 isozymes] an [amino group carrier protein]- LEP1GSC102_RS208985 [+ 4 isozymes] dependent: H-hydrate epimerase: a [protein]-N -(3- 1-phosphate containing protein: LEP1GSC102_RS222830 (2S,3R,4S,5R)-2-(5- reductase: reductase: precorrin-6B a [chaperone- a tetrahydrofolate a tRNA Val L-cysteine reactive oxygen species degradation an odd numbered [+ 3 isozymes]a 2-methyl (glutathion-S-yl)(1H- ADP coenzyme A H + LEP1GSC102_RS220595 1-cis-vaccenoyl- an [2Fe-2S] phosphatase: lipoyl-L-lysine protoporphyrin IX Amine and Polyamine Biosynthesis [+ 2 isozymes] [+ 3 isozymes] γ a nucleoside 5'- LEP1GSC102_RS208230 LEP1GSC102_RS218100 O-phospho-D- adenylyltransferase: LEP1GSC102_RS214455 a cis,cis-fabG a cis,cis-fabG ADP]-[disordered- dimethylbenzimidazole ATP:cob(I)alamin [+ 4 isozymes] 16-hydroxypalmitoyl- straight chain branched C-terminal- -(5-phospho- a tRNA 2-palmitoleoyl-sn- a malonyl-[acp] a 2'- hydroxy-1,3-benzodiazol- cluster protein cobC AMP diphosphate diphosphate AMP AMP diphosphate diphosphate AMP decanoyl-CoA indol-3-yl)acetonitrile monophosphate fructosyl)-L-lysine rfaE2 dITP delta17,35-3- delta13,25-3- form scaffold phosphoribosyltransferase: adenosyltransferase: CoA 2,3,4-saturated 2,3,4-saturated L-glutamyl)-L-glutamate glycerol-3-phosphate deoxyribonucleoside NADH ADP-D-glycero-β- [+ 14 isozymes] 1-yl)-5-(hydroxymethyl) cobT LEP1GSC102_RS207985 phosphopantothenate biosynthesis I ferrochelatase: spermidine biosynthesis III NADH repair superoxide cyclic-AMP oxolane-3,4-diol oxo-C54:2-[acp] oxo-C44:2-[acp] protein] complex adenosylcobalamin 5-methoxybenzimidazole a [prolipoprotein]- a [glycine-cleavage a [glycine-cleavage fatty acyl CoA fatty acyl-CoA 5'-diphosphate D-manno-heptose hemH 6 non-chaperonin molecular 6 complex H protein] N - cobalt-precorrin-7 ribotide phosphate adenosylcobinamide 3-methyl-2- adeninyl adenosylcobamide S-1,2-diacyl-sn- complex H protein] N chaperone ATPase: bifunctional a (6S)-5-formyltetrahydrofolate ala NADH aminomethyldihydrolipoyl- adenosylcobinamide- oxobutanoate biosynthesis from protoheme alanine--tRNA ligase: arg SAM glyceryl-L-cysteine -dihydrolipoyl-L-lysine 1-stearoyl- 1-myristoyl- a [lipoyl-carrier a cis,cis- a cis,cis- bifunctional cobalt-precorrin- LEP1GSC102_RS208560 bifunctional methylenetetrahydrofolate L-lysine 18-hydroxystearate octanoate adenosylcobinamide- α 1-chloro-2,4- glutathione a uracil in DNA 1-(18-hydroxyoleoyl)- 1-palmitoyl-sn- a nucleoside a [protein]-L- GDP ribazoletransferase: 3-methyl-2-oxobutanoate adenosylcobinamide-GDP LEP1GSC102_RS212880 hydrogen a nucleoside triphosphate a ribonucleic acid a palmitoyl-[acp] sn-glycerol -ribazole a [protein] Ser/Thr (R)-NADPHX sn-glycerol β cyclic-AMP protein]-N 6 -[(R) delta15,33- delta11,23-3- 7 (C(5))-methyltransferase/ an [Fe-S cluster a [disordered- adenosylcobinamide methylenetetrahydrofolate dehydrogenase/ 5-formyltetrahydrofolate an L-alanyl- lipoprotein signal peptidase: GDP dinitrobenzene sn-glycrol 3-phosphate glycerol 3-phosphate triphosphate -isoaspartate IDP LEP1GSC102_RS224485 hydroxymethyltransferase: methenyltetrahydrofolate cyclo-ligase: [tRNA Ala ] arginine decarboxylase, S-adenosylmethionine peroxide DNA-directed RNA long-chain fatty 3-phosphate1-acyl-sn-glycerol-3- long-chain fatty adenosylcobinamide- glutathione S-transferase: uracil-DNA glycosylase: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- serine/threonine bifunctional ADP-dependent 3-phosphate 1-acyl-sn-glycerol-3- protein-L-isoaspartate cAMP/cGMP-dependent -dihydrolipoyl]- 3-hydroxy hydroxyC42:2- cobalt-precorrin-6B (C(15) biosynthesis form [Fe-S] cluster α α kinase/adenosylcobinamide- reductase [NAD(P)H]: metF Ala LEP1GSC102_RS219000 nucleoside triphosphate Co -[ -(5- panB cyclohydrolase: LEP1GSC102_RS218690 adenine a tRNA biosynthetic: decarboxylase proenzyme: polymerase: rpoC rpoB acid--CoA ligase: phosphate acyltransferase: acid--CoA ligase: GDP ribazoletransferase: LEP1GSC102_RS213820 LEP1GSC102_RS213250 phosphate acyltransferase: phosphate acyltransferase: protein kinase: NAD(P)H-hydrate phosphate acyltransferase: O-methyltransferase: 3',5'-cyclic-AMP/GMP nucleoside- L-lysine dihydrolipoyl C52:2-[acp]3-ketoacyl- [acp] 3-ketoacyl- a reduced )-methyltransferase: chaperone]-ATP scaffold protein] β phosphate pyrophosphohydrolase: methoxybenzimidazolyl)]-Co - LEP1GSC102_RS225235 nicotinate-nucleotide-- LEP1GSC102_RS211825 LEP1GSC102_RS211825 an (S-diacyl-sn- catalase: LEP1GSC102_RS209125 LEP1GSC102_RS215930 LEP1GSC102_RS209125 LEP1GSC102_RS224485 glutathione S-transferase: uracil-DNA glycosylase: LEP1GSC102_RS215930 LEP1GSC102_RS215930 LEP1GSC102_RS215415 dehydratase/NAD(P) LEP1GSC102_RS215930 LEP1GSC102_RS218270 phosphodiesterase: diphosphate kinase: dehydrogenase: ACP ACP H O c-type LEP1GSC102_RS212675 guanylyltransferase: 2-dehydropantoate a lipoprotein (R)-NADHX DNA-directed RNA LEP1GSC102_RS223235 2 adenosylcobamide 5'-phosphate a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate dimethylbenzimidazole LEP1GSC102_RS225205 [+ 3 isozymes] [+ 3 isozymes] LEP1GSC102_RS208985 LEP1GSC102_RS208450 [+ 3 isozymes] H-hydrate epimerase: a protein L-β- LEP1GSC102_RS225455 LEP1GSC102_RS222830 lpdA reductase: reductase: cytochrome cytochrome folate transformations I LEP1GSC102_RS212635 agmatine dAdoMet glyceryl)-L-cysteinyl- signal peptide glycine cleavage polymerase subunit alpha: [+ 4 isozymes]1-stearoyl- 2,4-dinitrophenyl- 1-[18-hydroxyoeoyl]-2-[+ 4 isozymes] 1-palmitoyl-2-[+ 4 isozymes] 1,2-dimyristoyl-[+ 4 isozymes] a nucleoside 5'- an oxidized bifunctional ADP-dependent GMP adenosylcobalamin an apyrimidinic a [protein] (L-serine/L- LEP1GSC102_RS218100 isoaspartate a [lipoyl-carrier a cis,cis-fabG a cis,cis-fabG c oxidase cobalt-precorrin-8 alpha-ribazole 2-dehydropantoate phosphoribosyltransferase: [apolipoprotein] system protein LEP1GSC102_RS210275 18-hydroxystearoyl- 2-palmitoyl- uracil [18-hydroxy-lioleoyl]-sn palmitoleoyl-sn- sn-glycerol monophosphate [+ 2 isozymes] O c-type bifunctional H O hydroxyl radical AMP diphosphate diphosphate AMP octanoyl-CoA S-glutathione site in DNA α AMP 6 2 adenosyl-cobinamide NAD(P)H-hydrate 2 acyl-carrier protein threonine) phosphate -methyl ester ITP protein]-N - delta15,33-3- delta11,23-3- phosphatase: cobC 2-reductase: cobT apolipoprotein N- H: gcvH O a ribonucleic acid CoA sn-glycerol -glycerol 3-phosphate glycerol 3-phosphate (S)-NADPHX 3-phosphate cytochromea reduced a tetrahydrofolate phosphate methylenetetrahydrofolate adenine ribotide asn polyamine dehydratase/NAD(P) 2 lipoyl-L-lysine oxo-C52:2-[acp] oxo-C42:2-[acp] Coα-[α-(5-methoxybenzimidazolyl) LEP1GSC102_RS222500 menaquinol-9 biosynthesis asparagine--tRNA ligase: acyltransferase: glycine 3-phosphate H O c-type dehydrogenase/ phosphate aminopropyltransferase 2: H-hydrate epimerase: 2 ]-Coβ-adenosylcobamide bifunctional 2-dehydropantoate LEP1GSC102_RS225240 an L-asparaginyl- LEP1GSC102_RS223180 cleavage system RS0207180 cytochrome siroheme biosynthesis methenyltetrahydrofolate LEP1GSC102_RS211815 a peptide (S)-NADHX LEP1GSC102_RS218100 an oxidized adenosylcobinamide 2-reductase: adenosylcobinamide- [tRNA Asn ] apolipoprotein N- protein T: gcvT cobyrinate glycine cyclohydrolase: demethylmenaquinol-9 a 3-methyl- 1-cis-vaccenoyl- 1-palmitoyl- 34 a cis,cis- (3R,5S)-3- O c-type kinase/adenosylcobinamide- LEP1GSC102_RS211290 tRNA Asn acyltransferase: cob(II)alamin- (2E)- an N-modified glutathione methylmercury D-sedoheptulose glutathione 4-hydroxy- a 1-acyl-sn-glycerol a cytidine a nucleoside a 3-oxohexacosanoyl- 2 LEP1GSC102_RS225235 GDP ribazoletransferase: 2-methyladeninyl 1 branched 2,3,4- MEP 5'-deoxyadenosine cytochrome cleavage uroporphyrinogen-III demethylmenaquinone S-methyl-5'- N -(3-aminopropyl) LEP1GSC102_RS218240 ATP [CblC-CblD methylmalonyl- hexadecenoate aminoacyl-[tRNA] hypoxanthine PRPP 7-phosphate 2-nonenal 3-phosphate adenine PRPP sn-glycerol- sn-glycerol in tRNA diphosphate delta13,31- hydroxy-1- predicted cobyrinate a,c- phosphate β LEP1GSC102_RS224485 adenosylcobamide biosynthesis long-chain fatty saturated fatty acid glutathione S-transferase: phosphoheptose isomerase: glutathione S-transferase: [acp] system -alanine 10 α α methyltransferase: thioadenosine agmatine CoA mutase 3-phosphate 3-phosphate 1-deoxy-D-xylulose- S-methyl-5'- 3-hydroxy pyrroline-5- ABC diamide synthase: guanylyltransferase: (R)-pantoate uroporphyrinogen-III C- an N -formyltetrahydrofolate Co -[ -(adenin- an N-acyl-(S-diacyl- complex] long-chain fatty aminoacyl-tRNA hydrolase: 1-acyl-sn-glycerol-3- adenine 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- tRNA (cytidine(34)-2'- nucleoside- 3-ketoacyl- sulfate sulfate protein β from adenosylcobinamide-GDP LEP1GSC102_RS211480 cob(I)yrinic acid acid--CoA ligase: hypoxanthine LEP1GSC102_RS213820 LEP1GSC102_RS219850 LEP1GSC102_RS213820 5-phosphate thioadenosine C50:2-[acp]3-ketoacyl- carboxylatepyrroline-5- transporter LEP1GSC102_RS212645 LEP1GSC102_RS212635 methyltransferase: cobA 9-yl)]-Co - sn-glyceryl)-L- L-methionine degradation acid--CoA ligase: LEP1GSC102_RS221875 phosphate acyltransferase: phosphoribosyltransferase: phosphate acyltransferase: phosphate acyltransferase: O)-methyltransferase: diphosphate kinase: ACP H: gcvH menaquinol-9 NADH a,c-diamide LEP1GSC102_RS212405 phosphoribosyltransferase: hpt glutathione S-transferase: phosphoheptose glutathione S-transferase: reductoisomerase: phosphorylase: ACP carboxylate of sulfate precorrin-1 adenosylcobamide 2-methyladenine cysteinyl-[lipoprotein] I (to L-homocysteine) LEP1GSC102_RS209125 peptidyl-tRNA hydrolase: LEP1GSC102_RS215930 LEP1GSC102_RS212735 LEP1GSC102_RS215930 LEP1GSC102_RS215930 LEP1GSC102_RS208815 LEP1GSC102_RS222830 reductase: cob(II)yrinate an N 10 - adenosylcobinamide- pantoate--beta- heme b biosynthesis adenosyltransferase: [+ 3 isozymes] LEP1GSC102_RS208985 isomerase: gmhA LEP1GSC102_RS208985 a 2'-O- LEP1GSC102_RS221010 mtnP reductase: reductase: glycine 5'-phosphate nicotinate-nucleotide-- asp [+ 3 isozymes]a 3-methyl- LEP1GSC102_RS208280 IMP (glutathion-S- a 1-acyl-2-[+ 4 isozymes] 1,2-dicis-[+ 4 isozymes] 1-palmitoyl-[+ 4 isozymes] a nucleoside 1-deoxy-D- a (3R)-3-fabG a,c-diamide formyltetrahydrofolate GDP alanine ligase: II (anaerobic) aspartate--tRNA ligase: a [cobalamin cobO adenosylcobalamin- an N-modified an uncharged methylmercury- D-glycero-D-manno- AMP methylcytidine 34 a cis,cis-fabG proC sulfate RS214780 sulfate cleavage uroporphyrinogen-III C- alpha-ribazole dimethylbenzimidazole spermidine met a [cyanocobalamin (2E)- branched yl)-4-hydroxy- arachidonoyl-sn- vaccenoyl- 2-myristoyl triphosphate xylulose 5- 5-deoxy-α-ribose hydroxyhexacosanoyl- LEP1GSC102_RS221510 LEP1GSC102_RS224930 an L-aspartyl- trafficking triphosphate [methylmalonyl- AMP diphosphate diphosphate AMP amino acid tRNA S-glutatione heptose 7-phosphate in tRNA adenine delta13,31-3- Hyp system methyltransferase: cobA uroporphyrinogen-III heme a biosynthesis phosphatase: phosphoribosyltransferase: S-adenosylmethionine reductase CblC] hexadecenoyl-CoA 2,3,4-saturated 2-nonenal glycerol 3-phosphate phosphatidate phosphatidate phosphate 1-phosphate [acp] asp 6 37 protein CblD] CoA mutase] protein bifunctional a (6S)-5- cobC cobT [tRNA ] N -L-threonylcarbamoyladenosine oxo-C50:2-[acp] methionine synthase: uroporphyrinogen α α asp synthase: fatty acyl-CoA methylenetetrahydrofolate formyltetrahydrofolate Co -[ -(adenin- tRNA -modified tRNA biosynthesis Co 2+ Co 2+ T: gcvT (R)-pantothenate precorrin-2 decarboxylase: protoheme 2-methyladenine LEP1GSC102_RS213775 CorA LEP1GSC102_RS212460 dehydrogenase/ 5-methoxy-6-methylbenzimidazolyl 7-yl)]-Coβ- 2+ 2+ LEP1GSC102_RS212090 protoheme IX ribotide phosphate SAM Mg Mg methenyltetrahydrofolate 5-formyltetrahydrofolate adenosylcobamide biosynthesis bifunctional precorrin- adenosylcobamide a long-chain 6 ω-saturated a 1-alkyl-sn 1-palmitoyl- a cis,cis- pantothenate kinase: coproporphyrinogen III farnesyltransferase: thr cob(II)alamin- an apo-["base- (15Z)- a (6S)-5- maltohexaose a [histone]-N - quinoxaline-2- GDP-α-D- 1-myristoyl-sn- ADP-D-ribose acetyl-CoA an organic a phosphate a 3-oxotetracosanoyl- a cis-delta21-3- cyclohydrolase: cyclo-ligase: from adenosylcobinamide-GDP 2 dehydrogenase/ 2,3,4-saturated glu aryl-carrier protein C55 dolichol -glycerol 3- sn-glycerol 3',5'-ADP delta11,29- LEP1GSC102_RS210010 cyoE adenosylcobinamide- threonylcarbamoyl- ATP [CblC-CblD off/His-on" tetracosenoate formyltetrahydrofolate acetyl-L-lysine carboxyl adenylate mannose glycerol 3-phosphate hydroperoxide monoester [acp] oxo-C40:1-[acp] bifunctional LEP1GSC102_RS225235 LEP1GSC102_RS218690 5-methoxy-6- sirohydrochlorin Inorganic Nutrient long-chain fatty fatty acid alpha-glucosidase: histone deacetylase: phosphate ADP-ribose phosphate 3-phosphate acetyl-CoA thioredoxin-dependent 3-hydroxy bifunctional oxygen-independent GDP ribazoletransferase: complex] B12-enzyme] long-chain fatty bifunctional acyl carrier dolichyl-phosphate 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- alkaline phosphatase: 3'(2'),5'-bisphosphate 3-ketoacyl- 3-ketoacyl- Mg 2+ MgtE Mg 2+ methylenetetrahydrofolate methylbenzimidazole (R)-4'- ferrochelatase: ferroheme o tyr AMP synthase: Metabolism cob(I)yrinic acid acid--CoA ligase: LEP1GSC102_RS219445 LEP1GSC102_RS209710 pyrophosphatase: acetyltransferase: thiol peroxidase: C48:2-[acp] methylenetetrahydrofolate nicotinate-nucleotide-- coproporphyrinogen LEP1GSC102_RS224485 tyrosine--tRNA ligase: acid--CoA ligase: folylpolyglutamate synthase/ protein: acpP mannose synthase: phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: LEP1GSC102_RS213990 nucleotidase CysQ: ACP 3-ketoacyl- ACP dehydrogenase/ phosphopantothenate LEP1GSC102_RS224430 glutathione biosynthesis α α LEP1GSC102_RS211365 a,c-diamide LEP1GSC102_RS212405 alpha-glucosidase: histone deacetylase: LEP1GSC102_RS221615 LEP1GSC102_RS216095 LEP1GSC102_RS215250 dehydrogenase/ a 5,10- dimethylbenzimidazole III oxidase: hemN heme A synthase: Co -[ -(2- LEP1GSC102_RS223650 LEP1GSC102_RS209125 dihydrofolate synthase: a quinoxaline-2- β-D-mannosyl-LEP1GSC102_RS214645 LEP1GSC102_RS215930 LEP1GSC102_RS214745 LEP1GSC102_RS215930 alkaline phosphatase: LEP1GSC102_RS209105 reductase: ACP reductase: methenyltetrahydrofolate an L-tyrosyl- threonylcarbamoyl- SAH selenate reduction adenosyltransferase: [+ 3 isozymes] LEP1GSC102_RS215985 LEP1GSC102_RS216060 [+ 3 isozymes] [+ 3 isozymes] methenyltetrahydrofolate methenyltetrahydrofolate methyladenin-9-yl)]-Co Tyr Secondary Metabolite Biosynthesis AMP carboxyl-[aryl- ω [+ 4 isozymes] D-ribofuranose fabG reductase: fabG serine phosphoribosyltransferase: sirohydrochlorin protoporphyrinogen IX LEP1GSC102_RS216205 [tRNA ] AMP synthase: [+ 3 isozymes] LEP1GSC102_RS208855 (C55 -saturated 1-myristoyl-2- AMP a 2-acyl-1-alkyl-[+ 4 isozymes] 1-palmitoyl-2-[+ 4 isozymes] LEP1GSC102_RS218805 a (3R)-3- a cis-delta21-3- cyclohydrolase: β-adenosylcobamide Tyr a [cobalamin cobO a holo-["base- a long-chain a (6S)-5- D-glucopyranose maltopentaose GDP a cis,cis-fabG predicted hydroxymethyltransferase: glyA cyclohydrolase: 5-methoxy-6-cobT cys glu a tRNA a [cyanocobalamin (15Z)- acetate a [histone]-L-lysine carrier protein] dolichyl palmitoleoyl-sn- 5-phosphate sn-glycerol cis-vaccenoyl acetoacetyl-CoA an alcohol an alcohol AMP hydroxytetracosanoyl- hydroxyC40:1- LEP1GSC102_RS225235 LEP1GSC102_RS225235 5'-phosphate (L-threonylcarbamoyl)LEP1GSC102_RS217270 adenosylhomocysteinase: selenate trafficking triphosphate off/His-on" AMP diphosphate AMP diphosphate 2,3,4-saturated formyltetrahydrofolate delta11,29-3- ATP-driven methylbenzimidazole bifunctional precorrin- ferroheme i benzimidazolyl adenosylcobamide preQ biosynthesis reductase CblC] tetracosenoyl-CoA phosphate) glycerol 3-phosphate 3-phosphate phosphatidate [acp] [acp] K + K + 5-methylbenzimidazolyl bifunctional glutamate- alpha-ribazole 0 myo-inositol biosynthesis adenylate LEP1GSC102_RS212450 sulfate adenylyltransferase: protein CblD] B12-enzyme] fatty acyl CoA oxo-C48:2-[acp] transporter ribotide phosphate 2 dehydrogenase/ biosynthesis from adenosylcobamide biosynthesis heme A synthase: -cysteine ligase phosphatase: LEP1GSC102_RS224420 of K+ 5-hydroxybenzimidazolyl adenosylcobinamide- sirohydrochlorin GshA/glutathione adenosylcobinamide-GDP D-glucopyranose a 5,10- adenosylcobamide biosynthesis GDP ribazoletransferase: from adenosylcobinamide-GDP LEP1GSC102_RS216205 cobC L-homocysteine sulfate adenylyltransferase a 5-methyltetrahydrofolate ferrochelatase: protoporphyrin IX synthetase GshB: Coα-[α-(2- benzimidazole tryptophan- GTP 6-phosphate di-trans,octa-cis a (1->4)- a 3,5,7,9,11,13,15- 1-palmitoyl- 1-oleoyl-sn a [protein]- (1S,2R)-1- a cis,cis- lipoate biosynthesis Trp 6 subunit CysD: 1-myristoyl-sn- maltoheptaose maltotriose a 1-acyl-sn-glycerol L(or D)-O- a cis-delta19-3- K(+)- methylenetetrahydrofolate from adenosylcobinamide-GDP LEP1GSC102_RS224485 5-methylbenzimidazole NaMN LEP1GSC102_RS224430 methyladenin-7-yl)]-Co a tRNA GTP an N -L- a palmitoleoyl-[acp] 18-hydroxyoleate pristanate UDP-α-D-glucose -undecaprenyl α-D-glucan hepta-oxo- 2,2-dichloroacetate sn-glycerol -glycerol 3- DNA with lesion oxaloacetate C-(indol-3- delta19,31-3- α α hydroxyferroheme i LEP1GSC102_RS210935 nicotinate-nucleotide-- -tRNA 3-phosphate L-histidine ser + + and incorporation Co -[ -(5-methoxy-6- nicotinate-nucleotide-- ferrochelatase: β threonylcarbamoyladenine 37 LEP1GSC102_RS224415 glycerol 3-phosphate long-chain fatty long-chain fatty phosphate alpha-glucosidase: alpha-glucosidase: alpha-glucosidase: glutathione S-transferase: 3-phosphate phosphate excinuclease ABC citrate synthase: yl)glycerol phosphoserine oxo-C38:1-[acp] K transporting K 5-hydroxybenzimidazole NaMN glutamate- -adenosylcobamide dimethylbenzimidazole ligase: trpS an L-tryptophanyl- cyclohydrolase adenosine 5'- 1-acyl-sn-glycerol-3- undecaprenyl- 1-acyl-sn-glycerol-3- hexadecanoyl-[PKS-acp] 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- histidine kinase: hydroxyC50:2- 3-ketoacyl- methylenetetrahydrofolate III (Bacillus) methylbenzimidazolyl)]- dimethylbenzimidazole siroheme hemH 7,8- Ins(3)P in tRNA acid--CoA ligase: acid--CoA ligase: LEP1GSC102_RS219445 LEP1GSC102_RS219445 LEP1GSC102_RS219445 aldo/keto reductase: LEP1GSC102_RS213820 subunit UvrC: LEP1GSC102_RS210175 3-phosphate tryptophan phosphoserine ATPase nicotinate-nucleotide-- β -cysteine phosphoribosyltransferase: [tRNA Trp ] I FolE: folE phosphoselenate phosphate acyltransferase: phosphate glucose phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: LEP1GSC102_RS222990 [acp] 3-ketoacyl- ACP reductase [NAD(P)H]: metF Co -adenosylcobamide phosphoribosyltransferase: dihydroneopterin LEP1GSC102_RS209125 LEP1GSC102_RS209125 alpha-glucosidase: alpha-glucosidase: alpha-glucosidase: LEP1GSC102_RS222730 LEP1GSC102_RS211180 synthase phosphatase an octanoyl-[acp] dimethylbenzimidazole ligase: gshA cobT trp LEP1GSC102_RS215930 phosphotransferase: LEP1GSC102_RS215930 glutathione S-transferase: LEP1GSC102_RS215930 LEP1GSC102_RS215930 citrate synthase: [+ 13 isozymes] ACP reductase: thioredoxin 5'-phosphate cobT protoheme γ-L-glutamyl- benzimidazole 3'-triphosphate inositol monophosphatase: L-phenylalanine degradation I (aerobic) LEP1GSC102_RS215985 LEP1GSC102_RS215985 LEP1GSC102_RS215985 [+ 2 isozymes] a [protein]- subunit SerB: serB di-trans,poly-cis-undecaprenyl phosphoribosyltransferase: alpha-ribazole 5-methylbenzimidazole assimilatory sulfate reduction III [+ 4 isozymes] [+ 3 isozymes] [+ 3 isozymes] LEP1GSC102_RS221535 [+ 4 isozymes] 9-hydroxy-3,5,7,11,13,15- LEP1GSC102_RS208985 [+ 4 isozymes] [+ 2 isozymes] LEP1GSC102_RS208725 reductase: fabG chloride RS216020 chloride pathway lipoyl(octanoyl) L-cysteine ribotide phosphate 6-carboxytetrahydropterin LEP1GSC102_RS224695 1-myristoyl-2- α-D-glucopyranosyl- a (1->4)- a 1-acyl-2-palmitoyl-sn a 1-palmitoyl-2- [+ 4 isozymes] DNA without N-phospho- beta: trpB a cis-delta19-3- phosphate biosynthesis cobT ribotide phosphate ferroheme a 18-hydroxyoleoyl- UMP D-glucopyranose maltohexaose D-glucopyranose α D-glucopyranose maltose hexaoxohexadecanoyl- glyoxylate dioleoyl citrate D-glyceraldehyde serine a cis,cis-fabG a [glycine-cleavagetransferase: lipB 5-hydroxybenzimidazole phosphatase: synthase: N-end rule pathway I (prokaryotic) (6R)-4a-hydroxy- acyl-carrier protein palmitoleoyl-sn- AMP diphosphate AMP diphosphate pristanoyl-CoA diphosphoundecaprenol -D-glucan acyl-sn-glycerol lesion hydroxyC38:1- bifunctional glutamate- adenosylcobinamide- [+ 2 isozymes] selenite CoA -glycerol 3-phosphate [PKS-acp] phosphatidate L-histidine 3-phosphate trp delta19,31-3- (2E,6E)-farnesyl 4-amino-2-methyl-5- an oxidized complex H protein] ribotide phosphate cobC adenosylcobinamide- LEP1GSC102_RS214785 tetrahydrobiopterin 4a-hydroxytetrahydrobiopterin sulfate glycerol 3-phosphate 3-phosphate [acp] IPP Coα-[α-(5-methoxy-6- -cysteine ligase GDP ribazoletransferase: leucyl/phenylalanyl-tRNA- oxo-C50:2-[acp] diphosphate diphosphomethylpyrimidine thioredoxin N 6 -octanoyl-L-lysine GDP ribazoletransferase: myo-inositol dehydratase: sulfate adenylyltransferase: chloride RS224460 chloride ditrans,polycis- adenosylcobinamide- methyl-benzimidazolyl)]- folate polyglutamylation GshA/glutathione LEP1GSC102_RS224485 thr 6-carboxytetrahydropterin -protein transferase: biosynthesis LEP1GSC102_RS224485 Coα-[α-(benzimidazolyl) threonine--tRNA ligase: LEP1GSC102_RS211910 LEP1GSC102_RS224420 undecaprenyl-diphosphate GDP ribazoletransferase: Coβ-adenosylcobamide Coα-[α-(5-methylbenzimidazolyl) synthetase GshB: synthase QueD: queD LEP1GSC102_RS217640 a [protein] β an N-terminal a Chi-site containing 34 5-(methylsulfanyl) a cis,cis- LEP1GSC102_RS210935 ]-Co -adenosylcobamide LEP1GSC102_RS218660 an L-threonyl- N-terminal L- sulfate adenylyltransferase 7,8-dihydrofolate + a guanine D-arabinofuranose a [release factor]- synthase [(2E,6E)-farnesyl- AIR LEP1GSC102_RS224485 ]-Coβ-adenosylcobamide 6-carboxy-5,6,7,8- 1-palmitoyl-sn- 7-hydroxylaurate phytenate NADPH H maltopentaose queuine a RNA-DNA hybrid 1-aminocyclopropane- MEP CTP an aldehyde a cis-delta17-3- thioredoxin- Coα-[α-(5- a tetrahydrofolate 5'-phosphate [tRNA Thr ] arginyl-[protein] a palmitoleoyl-[acp] monoglutamate double stranded RecA in tRNA 5-phosphate thr ile L-glutamine -2,3-dioxopentyl delta17,29-3- iron(III) iron(III) diphosphate specific]: phosphomethylpyrimidine a [lipoyl-carrier protein] 5'-phosphate tetrahydropterin leucyl-L-arginine selenodiglutathione subunit CysD: glycerol 3-phosphate alpha-glucosidase: 4'-phosphopantetheine ATP 1-carboxylate oxo-C36:1-[acp] RS212595 synthase: disulfide hydroxybenzimidazolyl)]-Coβ- glutathione alpha-ribazole a tRNA Thr (6R)-L-erythro-5,6,7,8- L-erythro-7,8- LEP1GSC102_RS224415 1-acyl-sn-glycerol-3- long-chain fatty long-chain fatty dihydrofolate reductase: DNA with a blunt end exodeoxyribonuclease V: tRNA guanosine(34) ribonuclease HI: 2-C-methyl-D- 2-dehydro-3- NAD(P)-dependent peptide chain 1-phosphate hydroxyC48:2- 3-ketoacyl-dicitrate dicitrate di-trans,octa-cisLEP1GSC102_RS221000 N 6 -octanoyl-L-lysine 7-carboxy-7- LEP1GSC102_RS219445 1-aminocyclopropane-1- branched-chain amino reductase: adenosylcobamide 5'-phosphate alpha-ribazole phosphatase: tetrahydrobiopterin dihydrobiopterin phosphate acyltransferase: acid--CoA ligase: acid--CoA ligase: LEP1GSC102_RS220920 LEP1GSC102_RS213650 phosphopantetheine transglycosylase Tgt: LEP1GSC102_RS225670 erythritol 4-phosphate deoxyphosphooctonate threonine dehydrogenase: alcohol dehydrogenase: release factor acireductone [acp] 3-ketoacyl- -undecaprenyl LEP1GSC102_RS213615 S-adenosyl-L-methionine cycle I bifunctional serine deazaguanine synthase: leucyl/phenylalanyl-tRNA- APS carboxylate deaminase: acid transaminase: ACP trxB lipoyl phosphatase: cobC cobC Aromatic Compound LEP1GSC102_RS215930 LEP1GSC102_RS209125 LEP1GSC102_RS212405 dihydrofolate reductase: alpha-glucosidase: recD adenylyltransferase: LEP1GSC102_RS215340 ribonuclease HII: cytidylyltransferase: aldolase: LEP1GSC102_RS221955 LEP1GSC102_RS221190 N(5)-glutamine synthase: mtnC ACP diphosphate HMP-P alpha-ribazole folylpolyglutamate synthase/ hydroxymethyltransferase: glyA thiamine diphosphate LEP1GSC102_RS209385 -protein transferase: a double stranded DNA LEP1GSC102_RS225315 LEP1GSC102_RS217170 reductase: synthase: lipA Biosynthesis phosphoadenylyl- [+ 3 isozymes] [+ 3 isozymes] LEP1GSC102_RS222220 LEP1GSC102_RS215985 LEP1GSC102_RS222835 34 LEP1GSC102_RS208020 methyltransferase: phosphatase: cobC Coα-[α-(5-methylbenzimidazolyl) biosynthesis I (E. coli) Coα-[α-(benzimidazolyl) LEP1GSC102_RS217640 a [protein] [+ 41-palmitoyl-2- isozymes] with a RecA protein 3'-dephospho- a queuosine LEP1GSC102_RS208110 4-(cytidine 5'-LEP1GSC102_RS214360 (S)-3-methyl-2- 1,2-dihydroxy-5- reductase: a cis-delta17-3-fabG iron(III) iron(III) undecaprenyl- dihydrofolate synthase: 10 7-carboxy-7- an N-terminal + 5,6,7,8- guanine an alcohol RS212585 bifunctional a [lipoyl-carrier SAM ]-Coβ-adenosylcobamide an N - β N-terminal L- glutathioselenol sulfate reductase: 7-hydroxylauroyl- NADP D-glucopyranose maltotetraose loaded 3' overhang CoA in tRNA a nucleoside 5'- DNA 2-oxobutanoate KDO-8P aminoacetone prmC (methylsulfanyl) a cis,cis-fabG dicitrate dicitrate diphosphate phosphatase: α α LEP1GSC102_RS208855 a 5,10- ]-Co -adenosylcobamide chorismate biosynthesis I L-lysyl-[protein] acyl-carrier protein palmitoleoyl-sn- tetrahydrofolate diphospho)-2-C- oxopentanoate a [release factor]-N 5 hydroxyC36:1- hydroxymethylpyrimidine a reduced protein]-N 6 -[(R)- Co -[ -(5-hydroxybenzimidazolyl) formyltetrahydrofolate ser deazaguanine leucyl-L-lysine L-glutamine degradation I LEP1GSC102_RS224410 AMP diphosphate diphosphate AMP phytenoyl-CoA monophosphate pent-1-en-3-one delta17,29-3- β methylenetetrahydrofolate HMP-PP serine--tRNA ligase: glycerol 3-phosphate CoA methyl-D-erythritol [acp] LEP1GSC102_RS221525 kinase/ thioredoxin dihydrolipoyl]-L-lysine ]-Co -adenosylcobamide bifunctional 7-cyano-7- -methyl-L-glutamine oxo-C48:2-[acp] thiamine phosphate LEP1GSC102_RS217095 D-erythrose sulfite di-trans,octa-cis- phosphomethylpyrimidine S-adenosylmethionine a tetrahydrofolate bifunctional folylpolyglutamate synthase/ an L-seryl- deazaguanine iron(III) iron(III) synthase: ser RS211550 undecaprenyl phosphate kinase: thiD synthase: folylpolyglutamate synthase/ [tRNA ] synthase: queC 4-phosphate gln dihydrofolate synthase: LEP1GSC102_RS221380 ser 3-deoxy-D-arabino- assimilatory sulfite dicitrate dicitrate thiamine diphosphate a tRNA a carboxy- 6-phospho 2251 38- a cis,cis- LEP1GSC102_RS213775 NAD phosphorylation dihydrofolate synthase: LEP1GSC102_RS208855 thiamine heptulosonate 7- imidazole glycerol hydrogen selenide 1-cis-vaccenoyl-sn- α phosphoenol an [HPr]- GDP-α-D- a dolichyl guanosine a uridine an L-aspartyl- long chain a cis-delta15-3- biosynthesis II (Bacillus) preQ reductase (NADPH): a palmitoleoyl-[acp] -linolenate pyruvate 2-oxobutanoate glutathione monochlorobimane cys adenylated-[ThiS glutathione RX D-glucono- F6P L-dopa ferroheme o delta15,27-3- HMP-PP glutathione-glutaredoxin and transhydrogenation LEP1GSC102_RS208855 0 Glycolysis phosphate synthase cyclase: pyruvate L-histidine ATP a ribonucleic acid mannose phosphate in 23S rRNA 40 in tRNA Asn lipoate biosynthesis met SAH an N 10 - phosphate phosphate synthase: glycolysis I (from glucose 6-phosphate) LEP1GSC102_RS224435 glycerol-3-phosphate phosphoenolpyruvate- [tRNA ] polyphosphate oxo-C34:1-[acp] redox reactions a 5,10- LEP1GSC102_RS221550 1-acyl-sn-glycerol-3- long-chain fatty acetolactate synthase: glutathione S-transferase: sulfur-carrier protein] glutathione S-transferase: dolichyl-phosphate 1,5-lactone 23S rRNA tRNA pseudouridine(38- diphosphate--fructose- Asp-tRNA(Asn) hydroxyC46:2- 3-ketoacyl- and incorporation I formyltetrahydrofolate thiamine- 3-deoxy- LEP1GSC102_RS213490 cysteine desulfurase: -protein 4,5-DOPA heme A synthase: a metal a metal NAD + methylenetetrahydrofolate HMP-PP gatA hydrogen sulfide phosphate acyltransferase: acid--CoA ligase: LEP1GSC102_RS214035 ilvB LEP1GSC102_RS213820 polynucleotide LEP1GSC102_RS213820 mannose synthase: 6-phosphogluconolactonase: (guanosine(2251)-2'-O)- 40) synthase TruA: 6-phosphate 1- /Glu-tRNA(Gln) polyphosphate [acp] 3-ketoacyl- ACP RS219760 lipoate biosynthesis menaquinol-7 biosynthesis monophosphate thiamine phosphate D-arabino- D-glucopyranose 6-phosphate LEP1GSC102_RS222330 phosphotransferase: ptsP dioxygenase extradiol: LEP1GSC102_RS216205 cation cation lipoate salvage I glutathione NAD+ kinase: LEP1GSC102_RS215930 LEP1GSC102_RS212405 acetolactate synthase, glutathione S-transferase: an [HPr protein]- adenylyltransferase PcnB: glutathione S-transferase: LEP1GSC102_RS214645 pgl methyltransferase RlmB: LEP1GSC102_RS214760 phosphotransferase: amidotransferase kinase 1: ppk1 ACP reductase: and incorporation II kinase: thiL synthase: pro heptulosonate [+ 7 isozymes] a thiocarboxy- a dolichyl β- LEP1GSC102_RS222405 an octanoyl-[acp] LEP1GSC102_RS212270 all-trans- [+ 4 isozymes] [+ 3 isozymes] large subunit, LEP1GSC102_RS208985 AMP ala N π -phospho- pyruvate LEP1GSC102_RS215735 LEP1GSC102_RS208985 2-O- LEP1GSC102_RS225220 [+ 2 isozymes] LEP1GSC102_RS212470 subunit GatA: gatA reductase: fabG methionine synthase: 1,4-dihydroxy- LEP1GSC102_RS221380 proline--tRNA ligase: glu 1-cis-vaccenoyl- (glutathion- [ThiS-Protein] a ribonucleic acid a glutathione- GDP D-mannosyl D-gluconate a pseudouridine 38- β-D-fructose 1,6- ferroheme a long chain a cis-delta15-3- thiamine 7-phosphate biosynthetic type: ilvB 2251 4,5-seco-dopa an L-asparaginyl- a cis,cis- (R)-lipoate octanoate lipoyl(octanoyl) + heptaprenyl glucose-6-phosphate L-histidine HX methylguanosine fabG a metal a metal LEP1GSC102_RS212460 NADP thiamine LEP1GSC102_RS221020 an L-prolyl- acyl-carrier protein 2-palmitoleoyl-sn- α 6-phosphate bisphosphate Asn polyphosphate hydroxyC34:1- S-ribosyl-L- 2-naphthoate diphosphate NAD phosphorylation and dephosphorylation diphosphate 3-dehydroquinate synthase: isomerase: AMP diphosphate -linolenoyl-CoA S-yl)-bimane S-conjugate phosphate 40 in tRNA [tRNA ] delta15,27-3- RS216125 lipoate--protein ligase: lipoate--protein ligase: transferase: lipB a reduced L-homocysteine phosphate [tRNA Pro ] glycerol-3-phosphate (S)-2-aceto-2-hydroxybutanoate in 23S rRNA [acp] cation cation a [lipoyl-carrier protein] homocysteine urea cycle oxo-C46:2-[acp] glutaredoxin NAD(P) transhydrogenase: a tRNA Pro LEP1GSC102_RS212370 LEP1GSC102_RS213265 LEP1GSC102_RS219240 LEP1GSC102_RS219240 N 6 -octanoyl-L-lysine demethylmenaquinol-7 thiamine- a [lipoyl-carrier protein] LEP1GSC102_RS224145 + (lipoyl)adenylate NAD 6 monophosphate menaquinol-6 biosynthesis 3-dehydroquinate N -octanoyl-L-lysine lipoyl glutaredoxin: LEP1GSC102_RS224140 demethylmenaquinone acyl carrier F6P Carbohydrate Degradation β a metal a metal geranylgeranyl kinase: thiL arg 1-stearoyl- 1-palmitoyl- (5Z,8Z,11Z,14Z,17Z) a guanine 527 a protein -L- RS209465 synthase: lipA LEP1GSC102_RS210940 methyltransferase: protein a 2,3,4-saturated a 2,3,4-saturated 2- a cis- coenzyme A a peptide with a porphobilinogen glutathione fenclorim rhodopin DHAP a peptide with a γ-carotene an L-glutamyl- NMN a cis,cis-delta5,17-3- a cis-delta13-3- cation cation lipoate--protein ligase: lipoyl type I 3-dehydroquinate an oleoyl-[acp] sn-glycerol sn-glycerol -icosapentaenoate pimeloyl-CoA ala with incorrect arabinopyranose Gln a [lipoyl-carrier a protein with diphosphate biosynthesis NADPH activation thiamine demethylmenaquinol-6 fatty acyl-[acp] lysophosphatidate vaccenoyl-[acp] penultimate glycine in 16S rRNA leader sequence [tRNA ] hydroxyC36:2[acp] oxo-C32:1-[acp] LEP1GSC102_RS219240 synthase: lipA menaquinol-8 biosynthesis LEP1GSC102_RS211480 alkaline phosphatase: NAD(P) transhydrogenase: phenylalanine--tRNA dehydratase: D-mannose degradation ammonium 1-acyl-sn-glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- long-chain fatty carboxypeptidase: glutathione S-transferase: disulfide bonds glycerol-3-phosphate signal 6 diphosphate demethylmenaquinone fructose-1,6-bisphosphatase: 6-phosphofructokinase: 8-amino-7- ribosomal RNA small subunit arabinose kinase: Asp-tRNA(Asn) 3-ketoacyl- 3-ketoacyl- a [lipoyl-carrier a [lipoyl-carrier protein]-N -[(R)- reduced L- (2E,6E)-farnesyl LEP1GSC102_RS213990 LEP1GSC102_RS224145 NAD+ kinase: an apo acyl- ligase subunit alpha: LEP1GSC102_RS217365 acid--CoA ligase: uroporphyrinogen synthase: LEP1GSC102_RS213820 carotenoid 1,2-hydratase: carotenoid 1,2-hydratase: 5'-nucleotidase cysteine residues menaquinol-7 LEP1GSC102_RS212270 methyltransferase: LEP1GSC102_RS223695 LEP1GSC102_RS212470 argininosuccinate phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: LEP1GSC102_RS222780 oxononanoate synthase: methyltransferase G: protein disulfide-isomerase: dehydrogenase (NAD(P)(+) LEP1GSC102_RS210195 peptidase I: lepB /Glu-tRNA(Gln) ACP ACP protein]-N 6 - protein]-N 6 -[(R)- dihydrolipoyl]-L-lysine diphosphate LEP1GSC102_RS224140 carrier protein LEP1GSC102_RS222900 D-mannopyranose carbamoyl-phosphate LEP1GSC102_RS212405 LEP1GSC102_RS212065 LEP1GSC102_RS224390 LEP1GSC102_RS224390 SurE: surE a metal a metal geranylgeranyl demethylmenaquinol-8 [+ 2 isozymes] holo-ACP LEP1GSC102_RS211480 lyase: argH LEP1GSC102_RS215930 LEP1GSC102_RS215930 LEP1GSC102_RS215930 [+ 3 isozymes] LEP1GSC102_RS211080 glutathione S-transferase: LEP1GSC102_RS217150 LEP1GSC102_RS217725 ): LEP1GSC102_RS213435 [+ 2 isozymes] amidotransferase reductase: reductase: RS223735 lipoyl-L-lysine dihydrolipoyl]-L-lysine 3-dehydroshikimate 6-phosphate synthase small chain: a peptide with a 8-amino-7- an N 7 - β cation cation pyrophosphate synthase: demethylmenaquinone synthase: menaquinol-6 phenylalanine--tRNA mannose-6- [+ 4 isozymes] [+ 4 isozymes] [+ 4 isozymes] [+ 3 isozymes] an amino acid coenzyme A LEP1GSC102_RS208985 1,1'-dihydroxy-1,1',2,2'- a protein sn-glycerol β-L-arabinose a leader sequence a peptide 1'-hydroxy- subunit GatA: gatA 1-( -D fabG fabG phe LEP1GSC102_RS218655 a 2,3,4-saturated 1-stearoyl-2- 1-palmitoyl-2- (5Z,8Z,11Z,14Z,17Z) preuroporphyrinogen 4-(glutathion- 527 a cis,cis- a cis-delta13-3- LEP1GSC102_RS220055 methyltransferase: acpS ligase subunit beta: shikimate β-D-fructose 1,6-bisphosphate phosphate isomerase: C-terminal glycine oxononanoate methylguanine tetrahydrolycopene with correct 3-phosphate 1-phosphate γ-carotene an L-glutaminyl- ribofuranosyl) a holo acyl- DHAP acyl-carrier protein 1,2-diacyl-sn- acyl-carrier protein oleoyl-sn-glycerol acyl-carrier protein cis-vaccenoyl -icosapentaenoyl-CoA S-yl)-fenclorim Gln delta5,17-3- hydroxyC32:1- LEP1GSC102_RS211480 + L-arginino- carbamoyl-phosphate in 16S rRNA [tRNA ] nicotinamide GGPP NADP LEP1GSC102_RS209395 an L-phenylalanyl- dehydrogenase: LEP1GSC102_RS208780 L-ornithine glycerol 3-phosphate 3-phosphate phosphatidate disulfide bonds oxo-C36:2-[acp] [acp] menaquinol-8 carrier protein succinate synthase large subunit: H + RS209080 H + [tRNA Phe ] aroE fructose-bisphosphate F6P a tRNA Phe aldolase: LEP1GSC102_RS210445 shikimate triose-phosphate isomerase: an N 6 -L- 1-stearoyl- 1-palmitoyl- a reduced α 6-methoxy-2-all- a 3- LEP1GSC102_RS219700 carbamoyl a sulfurated an acyl-[acyl- a [ThiI sulfur-carrier a [protein]- - phylloquinol a double glutathione (3Z)-hex- an apo [peptidyl- a cis-delta11-3- LEP1GSC102_RS225000 threonylcarbamoyladenine 37 sn-glycerol sn-glycerol a myristoyl-[acp] a pimeloyl-[acp] ala ferredoxin [iron- NADP + H + cys precorrin-8x trans-octaprenyl- an acyl phosphate Ins(2)P coenzyme A a protein acryloyl-CoA oxodocosanoyl- phosphate carrier protein] L-glutamate stranded DNA 3-en-1-ol biotin ATP NAD(P) shikimate kinase: ornithine [sulfur carrier] protein]-L-cysteine gamma-glutamyl glutathione S-transferase: 1,4-benzoquinone carrier protein] oxo-C30:1-[acp] + + Metabolic Regulator in tRNA tRNA (N(6)-L- 3-phosphate1-acyl-sn-glycerol-3- 3-phosphate 1-acyl-sn-glycerol-3- 8-amino-7- sulfur] cluster ferredoxin--NADP(+) exo: inositol monophosphatase: holo-ACP crotonyl-CoA [acp] 3-ketoacyl- 3-ketoacyl- H H LEP1GSC102_RS212520 argininosuccinate synthase: carbamoyltransferase: cysteine desulfurase: carboxylase: LEP1GSC102_RS213820 precorrin-8X methylmutase: demethylmenaquinone biotin--[acetyl-CoA- HslU--HslV peptidase transhydrogenase Fatty Acid and Lipid Biosynthesis Biosynthesis threonylcarbamoyladenosine(37) phosphate acyltransferase: phosphate acyltransferase: oxononanoate synthase: reductase: LEP1GSC102_RS213655 acylphosphatase: LEP1GSC102_RS224695 synthase: carboxylase/ ACP ACP Carbohydrate Biosynthesis LEP1GSC102_RS222840 LEP1GSC102_RS220785 a [ThiI sulfur- LEP1GSC102_RS222330 LEP1GSC102_RS222410 LEP1GSC102_RS212680 methyltransferase: carboxylase] ligase: ATPase subunit: met shikimate 3- D-glyceraldehyde 3-phosphate -C(2))- methylthiotransferase LEP1GSC102_RS214745 LEP1GSC102_RS215930 LEP1GSC102_RS211080 an oxidizedLEP1GSC102_RS217045 a [protein] LEP1GSC102_RS213650 glutathione S-transferase: LEP1GSC102_RS222720 acpS reductase: reductase: reductase: methionine--tRNA ligase: L-citrulline carrier protein]-S- ala vitamin K LEP1GSC102_RS211480 [+ 2 isozymes] LEP1GSC102_RS210015 LEP1GSC102_RS208295 ppGpp biosynthesis 6 8-amino-7- recD LEP1GSC102_RS208985 3-methyl-6-methoxy- a holo [peptidyl- ccrA palmitate biosynthesis II (bacteria and plants) an L-methionyl- phosphate MtaB: LEP1GSC102_RS223930a 2-methylsulfanyl-N -L- [+ 4a isozymes]1-stearoyl 2- [+ 4 1-palmitoyl-isozymes] acyl-carrier protein NADPH ferredoxin [iron- 4-carboxy- biotinyl-5'- 3',5'-ADP a (3R)-3-fabG a cis-delta11-3-fabG F0F1 ATP O-antigen building blocks biosynthesis (E. coli) LEP1GSC102_RS213365 sulfanyl-L-cysteine 2,3-epoxide 3-(glutathion-S hydrogenobyrinate a carboxylate myo-inositol (R)-methylmalonyl- + + stearate biosynthesis phosphatidylserine and glyceraldehyde- an unsulfurated 37 oxononanoate a 5'-phosphooligonucleotide 2-octaprenyl-1,4- carrier protein] H H GDP-L-fucose biosynthesis PRPP biosynthesis [elongator 3-phosphoshikimate 1- met 5'-deoxyadenosine threonylcarbamoyladenine acyl-carrier protein acyl-sn-glycerol acyl-carrier protein 2-myristoyl sulfur] cluster L-glutamate -yl)-hexan-1-ol adenylate a peptide CoA hydroxydocosanoyl- hydroxyC30:1- synthase II (bacteria and plants) phosphatidylethanolamine Met [sulfur carrier] benzoquinone pppGpp UDP-α-D- α-D- D-glucopyranose I (from GDP-D-mannose) elongator tRNA ] 3-phosphate Nucleoside and Nucleotide Degradation thiosulfate disproportionation in tRNA 3-phosphate phosphatidate [acp] [acp] Met carboxyvinyltransferase: an acetoacetyl-[acp] biosynthesis I bifunctional (p)ppGpp galactose glucopyranose D-ribose 5- tRNA dehydrogenase: gap IV (rhodanese) 6-phosphate α aroA a palmitoyl-[acp] a CDP-diacylglycerol synthetase/guanosine- 1-phosphate glucose-6-phosphate GDP- -D-mannose phosphate 5-enolpyruvoyl- adenosine nucleotides glucose-1-phosphate GDP-mannose ribose-phosphate 1-myristoyl- 1-cis-vaccenoyl- 1402 a cis,cis-delta9,21- a (9Z)-3- 3-ketoacyl-ACP CDP-diacylglycerol--serine peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis 3',5'-bis(diphosphate) 3'- isomerase: shikimate 3- degradation II thiosulfate a cis- an L-phenylalanyl- an N-terminal a ferrocytochrome a protein with (S)-2-aceto-2- a monocarboxylic (6E)-8- a cytidine Peptide RS218935 Peptide guanosine 3'-diphosphate UDP-Galf thymidylyltransferase: 4,6-dehydratase: pyrophosphokinase: 13-DPG O-acetyl-L-serine hydrogen selenide a myristoyl-[acp] sn-glycerol sn-glycerol- stearoyl-CoA glutathione isobutanoate D-threo-isocitrate 2-hydroxyisobutyramide a phenyl acetate Ins(1)P butanoyl-CoA crotonyl-CoA 3-hydroxyC40:2- oxooctacos- reductase: fabG O-phosphatidyltransferase: pyrophosphohydrolase: LEP1GSC102_RS213265 phosphate inosine 5'- rhodanese domain- vaccenoyl-[acp] [tRNA Phe ] L-lysyl-[protein] b a disulfide bond hydroxybutanoate acid amide oxogeraniol in 16S rRNA 5 arylesterase: a 3-oxooctadecanoyl- UDP-N-acetyl- 5'-triphosphate 3'- LEP1GSC102_RS221815 F6P gmd LEP1GSC102_RS221885 lysine- phosphate O-acetylhomoserine 3-phosphate1-acyl-sn-glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- leucyl/phenylalanyl-tRNA- acetate--CoA isocitrate lyase/ acyl-CoA dehydrogenase: NAD(P)-dependent 16S rRNA crotonyl-CoA [acp] 3-ketoacyl- 9-enoyl-[acp]3-ketoacyl- pssA α LEP1GSC102_RS215500 GDP-4-dehydro- PRPP a tRNA Lys chorismate synthase: containing protein: acyl-CoA desaturase: glutaredoxin: ketol-acid reductoisomerase: amidase: LEP1GSC102_RS214050 amidase: inositol monophosphatase: a (3R)-3- a 3-sn-phosphatidyl- -D-glucosamine diphosphatase: glucose-1-phosphate α -tRNA AMP degradation aminocarboxypropyltransferase/ phosphate acyltransferase: phosphate acyltransferase: -protein transferase: ligase: acs phosphoenolpyruvate LEP1GSC102_RS216110 alcohol dehydrogenase: (cytidine(1402)-2'-O) carboxylase/ ACP ACP [acp] glutamine--fructose- -D-rhamnose phosphoglycerate LEP1GSC102_RS215475 LEP1GSC102_RS212285 LEP1GSC102_RS210940 LEP1GSC102_RS224325 LEP1GSC102_RS218985 LEP1GSC102_RS218985 LEP1GSC102_RS224695 hydroxybutanoyl-[acp] L-serine UDP-N-acetylglucosamine LEP1GSC102_RS215500 thymidylyltransferase: ligase: lysS LEP1GSC102_RS216520 cysteine synthase: LEP1GSC102_RS215930 LEP1GSC102_RS215930 LEP1GSC102_RS217640 a protein with mutase family protein: arylesterase: [+ 10 isozymes] LEP1GSC102_RS221190 -methyltransferase: reductase: reductase: reductase: 3-ketoacyl- 6-phosphate GDP-L-fucose synthase: an L-lysyl- kinase: pgk 5'-nucleotidase thiosulfate sulfurtransferase: a ferricytochrome [+ 2 isozymes] fluoride RS216735 fluoride 1-carboxyvinyltransferase: Phe L-phenylalanyl- oleoyl-CoA reduced L- GSSG isobutanoyl-CoA AMP diphosphate LEP1GSC102_RS219255 LEP1GSC102_RS223875 rsmI ccrA phosphatidylserine α rfbA [tRNA Lys ] IMP LEP1GSC102_RS210735 [+ 1,2-dimyristoyl-4 isozymes] [+ 4 isozymes]1,2-dicis- a tRNA b (R)-2,3-dihydroxy- 2-hydroxy-2- (6E)-8- a 2'-O- a cis,cis-fabG a cis-delta9-3-fabG ACP dTDP- -D-glucose aminotransferase: LEP1GSC102_RS219840 chorismate SurE: surE LEP1GSC102_RS215975 L-lysyl-[protein] 5 cysteine residues a monocarboxylate myo-inositol crotonyl-CoA (2S)- decarboxylase: psd murA IMP thiocyanate 3-methylpentanoate succinate glyoxylate methylpropanoate acetate a phenol oxogeranial methylcytidine 1402 reductase: glmS GDP-4-dehydro-6- lys sulfite acetate L-selenocysteine acyl-carrier protein sn-glycerol acyl-carrier protein vaccenoyl- ethylmalonyl-CoA delta9,21-3- hydroxyC28:1- UDP-N-acetyl-α- GTP ppGpp dTDP- adenosine dehydrogenase: in 16S rRNA fabG an L-1- D-glucosamine deoxy-β-L-galactose 3-phospho-D-glycerate 3-phosphate phosphatidate oxo-C40:2-[acp] [acp] a (3R)-3- D-glucosamine- glucose 4,6- guaB a (2E)-but-2-enoyl-[acp] phosphatidylethanolamine 6-phosphate GDP-L-fucose synthase: hydroxyoctadecanoyl- enolpyruvate dehydratase: adenosine deaminase: XMP rfbB phosphoglucosamine LEP1GSC102_RS219840 2,3-bisphosphoglycerate- 2,3-bisphosphoglycerate- LEP1GSC102_RS222750 a [2-oxoglutarate- 1-palmitoyl- trans,octacis- a peptide with a 2'- an insertion sequence 2,5-dichloro-trans (3Z)-hex- a cytidine 1402 4-methylphenyl-Co a cis,cis-delta9,27- phosphoenol [acp] UDP-N- O-acetyl-L- PRPP a 5-L-glutamyl- demethylmenaquinol-4 a folate rhodopin ethylphosphate uroporphyrinogen-III β mutase: glmM his independent independent adenosine phosphate acquisition dehydrogenase a sulfurated methanethiol a palmitoyl-[acp] sn-glycerol decaprenyl phosphate an N-terminal an amino acid deoxyribonucleoside [DNA] element IS30 -dienelactone 3-en-1-ol in 16S rRNA -adenosylcobamide 3-hydroxyC46:2- pyruvate acetylenolpyruvoylglucosamine dTDP-glucose β SAM 6 homoserine [peptide] GDP pyrophosphokinase: GDP- -L-fucose histidine--tRNA ligase: phosphoglycerate mutase: phosphoglycerate mutase: 5'-nucleotidase E2 protein] N - [sulfur carrier] 3-phosphate decaprenyl-phosphate Xaa-L-proline 5'-triphosphate dihydrofolate reductase: ribosomal RNA 5'-phosphate [acp] pyruvate reductase: bifunctional (p)ppGpp 4,6-dehydratase: α-D-glucosamine deaminase: add O-acetylhomoserine 1-acyl-sn-glycerol-3- leucyl aminopeptidase: gamma- DNA polymerase I: transposase: demethylmenaquinone acid phosphatase: CHAT domain- uroporphyrinogen-III 3-ketoacyl- LEP1GSC102_RS215500 LEP1GSC102_RS217410 an L-histidyl- LEP1GSC102_RS222095 LEP1GSC102_RS222095 SurE: surE octanoyl-L-lysinelipoyl phosphoribosyltransferase: dienelactone hydrolase: LEP1GSC102_RS222220 carotenoid 1,2-hydratase: small subunit alpha-ribazole kinase: pyk long-chain fatty LEP1GSC102_RS213410 synthetase/guanosine- LEP1GSC102_RS216215 1-phosphate a phosphate aminocarboxypropyltransferase/ phosphate acyltransferase: LEP1GSC102_RS215255 glutamyltransferase: ggt LEP1GSC102_RS222540 LEP1GSC102_RS215485 methyltransferase: LEP1GSC102_RS217405 containing protein: C-methyltransferase: ACP nucleoside- [tRNA His ] synthase: a peptide with an α-(5-L- LEP1GSC102_RS224060 LEP1GSC102_RS224390 methyltransferase phosphatase: acid activation ala UDP-N-acetyl- 3',5'-bis(diphosphate) 3'- inosine monoester a [2-oxoglutarate cysteine synthase: LEP1GSC102_RS215930 trans,octacis- LEP1GSC102_RS224205 a proteinogenic [+ 6 isozymes] [+ 12 isozymes] LEP1GSC102_RS211480 dihydrofolate reductase: LEP1GSC102_RS221105 cobA reductase: pyruvate a butanoyl-[acp] a (2E)-octadec- dTDP-4-dehydro- glucosamine-1-phosphate a tRNA His lipA [+ 2 isozymes] cobC α diphosphate kinase: 2-phospho-D-glycerate acid phosphatase: β an N-terminal a peptide glutamyl)- LEP1GSC102_RS220920 4 H: mraW kinase: pyk 2-enoyl-[acp] a long-chain -D-muramate pyrophosphohydrolase: 6-deoxy-α-D- acetyltransferase: xanthosine an unsulfurated dehydrogenase LEP1GSC102_RS210735 [+ 4 isozymes] decaprenylphospho- -D- amino acid [DNA] an insertion sequence IS30 2,5-dichloromaleylacetate menaquinol-4 all-trans-lycopene (3Z)-hex-3- precorrin-2 an N - 4-methylphenyl-Co a cis,cis-fabG lipid IV biosynthesis LEP1GSC102_RS222830 LEP1GSC102_RS217405 5'-deoxyadenosine met 6 dipalmitoyl L-proline amino acid ethanol 1402 β-ketohexanoyl- A LEP1GSC102_RS215500 [sulfur carrier] E2 protein] N acetate met acyl-carrier protein ribofuranose 5-phosphate with integrated transposon a 7,8-dihydrofolate en-1-yl acetate methylcytidine β-adenosylcobamide delta9,27-3- pyruvate fatty acid long-chain fatty glucopyranose LEP1GSC102_RS221890 UDP-α-D-galactose phosphate phosphatidate [acp] synthase: UDP-N-acetylmuramate- a (3R)-3- GDP dTDP-4- N-acetyl-α-D- enolase: -lipoyl-L-lysine in 16S rRNA oxo-C46:2-[acp] LEP1GSC102_RS219310 acid--CoA ligase: -alanine ligase: UDP-N-acetyl- biosynthesis hydroxytetradecanoyl- α dehydrorhamnose glucosamine LEP1GSC102_RS225565 LEP1GSC102_RS212405 LEP1GSC102_RS222895 -D-glucosamine [acp] 3,5-epimerase: rfbC 1-phosphate UDP-α-D-glucose gly a [pyruvate a 1-acyl-sn all-trans- 3-[(4'- phenyl-Coβ- a cis,cis-delta7,25- a 3-oxohexanoyl-[acp] a stearoyl-[acp] [+ 3 isozymes] glu UDP-N- UDP-3-O-[(3R)-3- glycine--tRNA ligase: hypoxanthine an acyl-[acyl- (5Z,8Z,11Z,14Z,17Z) (S)-4-amino-5- an unsulfurated adenosyl-cob(III) maltose a long-chain dTDP-4-dehydrorhamnose UDP-N-acetylglucosamine UDP-glucose xanthine dehydrogenase a sulfurated -glycerol 3- DL-allothreonine a tRNA glu octaprenyl 4-hydroxybenzoate cys chlorobactene 4-guanidinobutyramide palmitoyl-CoA DMKH2-13 cholesterol methylsulfanyl) adenosylcobamide 3-hydroxyC44:2- (S)-malate acetylmuramate- hydroxymyristoyl]-N- LEP1GSC102_RS219160 SAM dGTP carrier protein] -icosapentaenoyl-CoA oxopentanoate [sulfur carrier] yrinate a,c-diamide fatty acyl-CoA 3,5-epimerase: diphosphorylase: a glycyl-[tRNA Gly ] phosphoenolpyruvate taurine degradation IV E2 protein] N 6 - [sulfur carrier] phosphate acyl-CoA thioesterase: diphosphate alpha-glucosidase: butyl]malate 5'-phosphate [acp] class II glutamate acetyl-α-D-glucosamine 4-epimerase 1-acyl-sn-glycerol-3- serine glutamyl-tRNA reductase: 4-hydroxybenzoate cysteine desulfurase: acyl-CoA dehydrogenase: demethylmenaquinone 3-ketoacyl- 3-ketoacyl-ACP -L-alanine LEP1GSC102_RS224725 LEP1GSC102_RS221890 octanoyl-L-lysinelipoyl deoxyguanosinetriphosphate LEP1GSC102_RS222175 carotenoid 1,2-hydratase: amidase: cobyric acid synthase: LEP1GSC102_RS219445 cholesterol oxidase: 3-isopropylmalate alpha-ribazole fumarate acyl-CoA hydrolysis racemase: UDP-3-O-acyl-N- GalE: galE a tRNA Gly phosphate acyltransferase: hydroxymethyltransferase: glyA LEP1GSC102_RS212060 octaprenyltransferase: LEP1GSC102_RS222330 LEP1GSC102_RS216110 methyltransferase: ACP reductase: fabG ligase: murC UDP-N-acetyl- synthase: triphosphohydrolase: [+ 4 isozymes] LEP1GSC102_RS224390 LEP1GSC102_RS218985 LEP1GSC102_RS212630 alpha-glucosidase: LEP1GSC102_RS222640 dehydrogenase: phosphatase: hydratase: acetylglucosamine dTDP-4-dehydro- [+ 2 isozymes] taurine a [pyruvate LEP1GSC102_RS214745 an L-glutamyl- ubiA a sulfurated [+ 10 isozymes] LEP1GSC102_RS211480 reductase: murI α-D-glucosamine α pyruvate kinase: pyk lipA LEP1GSC102_RS209265 gly acetaldehyde (5Z,8Z,11Z,14Z,17Z) 3-octaprenyl-4- ala LEP1GSC102_RS215985 leuB cobC a (3R)-3- a 2,3,4-saturated β-L-rhamnose UDP- -D-galactose [+ 4 isozymes] coenzyme A [tRNA Glu ] (2E)- cholest-4- fabG fumC stearate UDP-N-acetyl- deacetylase: pyruvate kinase: pyk urate taurine dioxygenase: an unsulfurated 5'-deoxyadenosine met dehydrogenase 2'-deoxyguanosine triphosphate a 1,2-diacyl- -icosapentaenoate [sulfur carrier] 1-hydroxychlorobactene 4-guanidinobutanoate adenosylcobyrate menaquinol-13 7-(methylsulfanyl) phenyl-Coβ- a cis,cis- xanthine 6 hydroxybenzoate D-glucopyranose hydroxyhexanoyl-[acp] fatty acyl CoA D-glt α-D-muramoyl- LEP1GSC102_RS209140 dTDP-4- LEP1GSC102_RS215465 [sulfur carrier] E2 protein] N acyl-carrier protein sn-glycerol hexadecenoyl-CoA en-3-one -2-oxoheptanoate adenosylcobamide delta7,25-3- fumarate long-chain fatty acyl-CoA thioesterase: UDP-3-O-(3- dehydrorhamnose LEP1GSC102_RS218555 L-alanine 2-aminoacetaldehyde -lipoyl-L-lysine 3-phosphate oxo-C44:2-[acp] acid--CoA ligase: hydroxymyristoyl) reductase: rfbD met pyruvate [+ 4 isozymes] methionine--tRNA ligase: LEP1GSC102_RS209125 a 2,3,4-saturated UDP-N- -α-D-glucosamine dTDP-β-L- LEP1GSC102_RS213365 undecaprenyl-diphospho-N 3-benzyl-3,6-dihydroxy- α UDP-N-acetyl- an N-terminal- 3-[(6'- [+ 3 isozymes] fatty acid acetylmuramoyl- UDP-3-O-(3- rhamnose an L-methionyl- pyrimidine deoxyribonucleotides (3E,5Z)-tetradeca- 3-oxo-(9Z)- -D- 2-chloro-trans (7Z)- a ribonucleoside a cis,cis-delta5,23- Met urate γ α indolylmethylisothiocyanate glutathione a ferrocytochrome 1-hydroxyneurosporene a cytosine in DNA α DMK-12 a (2E)-hex-2-enoyl-[acp] hydroxymyristoyl) [initiator tRNA ] -acetylmuramoyl-L-alanyl- - UDP-N-acetyl- -D-glucosamine 6-(hydroxymethyl) glutathione palmitoyl-CoA 3,5-dienoyl-CoA hexadecenoyl-CoA glucopyranose UTP a type IV prepilin -dienelactone hexadecenoyl-CoA -D-glucosamine L-methionyl-L- methylsulfanyl) 3-hydroxyC42:2- L-alanine-- Met Respiration dephosphorylation b 5'-monophosphate stearoyl-CoA initiator tRNA D-glutamyl-L-lysyl- D-alanine glutathione S-transferase: -diketopiperazine 5 acyl-CoA thioesterase: acetyl-CoA C- UDP-N- seryl-[protein] hexyl]malate D-glutamate glucosamine N- nucleoside triphosphate undecaprenyldiphospho- glutathione S-transferase: acyl-CoA desaturase: 1-phosphate UTP--glucose-1-phosphate prepilin peptidase: acyl-CoA dehydrogenase: demethylmenaquinone type I methionyl [acp] 3-ketoacyl- LEP1GSC102_RS213820 LEP1GSC102_RS222175 acyltransferase: carotenoid 1,2-hydratase: dienelactone hydrolase: DNA methylase: acetylglucosamine 3-isopropylmalate 5'-nucleotidase ligase: murD acyltransferase: pyrophosphohydrolase: muramoylpentapeptide beta-N- LEP1GSC102_RS213820 LEP1GSC102_RS212285 uridylyltransferase: LEP1GSC102_RS218845 LEP1GSC102_RS216110 methyltransferase: aminopeptidase: ACP 2-oxoglutarate decarboxylation to succinyl-CoA [+ 4 isozymes] LEP1GSC102_RS210020 LEP1GSC102_RS224390 LEP1GSC102_RS224060 LEP1GSC102_RS219975 2-epimerase dehydrogenase: SurE: surE LEP1GSC102_RS213010 Amino Acid Biosynthesis LEP1GSC102_RS223235 acetylglucosaminyltransferase: glutathione S-transferase: glutathione S-transferase: a ferricytochrome LEP1GSC102_RS211620 a cleaved type [+ 10 isozymes] LEP1GSC102_RS211480 map reductase: LEP1GSC102_RS208985 palmitoleoyl-CoA coenzyme A (3E,5Z)- (7Z)- acetyl-CoA a peptide (hydrolyzing): neuC an N-terminal leuB fatty acid elongation -- saturated meso- UDP-N-acetyl- UDP-3-O-(3- a [2-oxoglutarate dCTP dCMP ditrans,octacis-undecaprenyldiphospho-LEP1GSC102_RS210675 indol-3-ylmethylisothiocyanate- 3-benzyl-3,6 -bis(glutathione)LEP1GSC102_RS208985 b tetradecadienoate tetradecenoyl-CoA UDP-α-D-glucose IV prepilin all-trans (2E,7Z)- a 5-methylcytosine N-acetyl-α-D- met 9-(methylsulfanyl) a cis,cis-fabG α 5 2-chloromaleylacetate UDP menaquinol-12 L-seryl-[protein] a ribonucleoside a hexanoyl-[acp] diaminopimelate -D-muramoyl-L- hydroxymyristoyl) L-histidine biosynthesis dehydrogenase UDP N-acetyl-(N-acetylglucosaminyl)muramoyl- glutathione - 6-(hydroxymethyl) neurosporene hexadecenoyl-CoA in DNA mannosamine -2-oxononanoate delta5,23-3- alanyl-D-glutamate L-arginine biosynthesis II (acetyl cycle) L-tryptophan biosynthesis L-methionine salvage cycle III L-homoserine biosynthesis L-alanine biosynthesis I 6 γ -diketopiperazine glucosamine N- E2 protein] N 2-oxoglutarate dUTP diphosphatase: Carboxylate Degradation L-alanyl- -D-glutamyl-L-lysyl-D-alanine oxo-C42:2-[acp] β-ketooctanoyl- an acetoacetyl-[acp] acyltransferase: -lipoyl-L-lysine UDP-N-acetylmuramoyl-L- PRPP 3-methyl-2- dehydrogenase subunit E1: LEP1GSC102_RS218220 [acp] synthase: LEP1GSC102_RS217040 N-acetylglutamyl- chorismate asp 2-oxoglutarate LEP1GSC102_RS218620 nucleoside triphosphate pyruvate decarboxylation to acetyl CoA a nascent peptidoglycan 4-(cytidine 5'-diphospho) 3 3-[(5'- ADP-D-glycero-β- a cis,cis-delta7,19- alanyl-D-glutamate--2, 6- UDP-2-N,3-O-bis[(3R)- phosphate met oxobutanoatebranched-chain amino adenosylcobinamide- phenyl ribotide an N -methyladenine 6-trans-3-oxo- 3-oxo- 5-chloro-trans LEP1GSC102_RS219310 D-ala ATP N-acetyl-gamma-glutamyl- 2-oxoglutaramate dehydrogenase subunit E1: pyrophosphohydrolase: (meso-DAP containing) 2,3,6-trichlorohydroquinone glutathione -2-C-methyl-D-erythritol a carboxypeptidase 1-hydroxyneurosporene palmitoleoyl-CoA trans-dienelactone thiosulfate DMKH2-11 acrylamide methylsulfanyl) D-manno-heptose 3-hydroxyC38:2- diaminopimelate ligase: 3-hydroxytetradecanoyl]- aspartate kinase: acid transaminase: GDP phosphate in DNA tridecenoyl-CoA palmitoyl-CoA -dienelactone phosphoribosyltransferase: phosphate reductase: anthranilate S-adenosylmethionine LEP1GSC102_RS218620 LEP1GSC102_RS223235 a [pyruvate dehydrogenase lytic transglycosylase glutathione S-transferase: adenosylcobinamide- 4-diphosphocytidyl-2C- DNA-3-methyladenine acetyl-CoA C- Taq substrate acetyl-CoA C- pentyl]malate ADP- [acp] a 3-oxooctanoyl-[acp] LEP1GSC102_RS210660 α-D-glucosamine acetylglutamate kinase: LEP1GSC102_RS208665 LEP1GSC102_RS217170 carboxypeptidase M32: acyl-CoA dehydrogenase: demethylmenaquinone 3-ketoacyl- D-alanine--D-alanine ligase: LEP1GSC102_RS218755 LEP1GSC102_RS211235 synthase: trpE synthase: [+ 3 isozymes] dUTP dUMP E2 protein] N 6 -lipoyl-L-lysinepyruvate domain-containing protein: LEP1GSC102_RS213820 GDP ribazoletransferase: methyl-D-erythritol kinase: glycosylase I: acyltransferase: acyltransferase: carotenoid 1,2-hydratase: dienelactone hydrolase: dienelactone hydrolase: thiosulfate sulfurtransferase: amidase: 3-isopropylmalate glyceromanno- LEP1GSC102_RS214610 UDP-2,3-diacylglucosamine LEP1GSC102_RS214595 L-aspartyl- a [2-oxoglutarate a [2-oxoglutarate dehydrogenase LEP1GSC102_RS217020 LEP1GSC102_RS216110 methyltransferase: dehydrogenase: ACP a 3-oxoacyl-[acp] UDP-N-acetyl- LEP1GSC102_RS213775 val LEP1GSC102_RS211865 glutathione S-transferase: LEP1GSC102_RS224485 LEP1GSC102_RS221900 LEP1GSC102_RS213080 LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS224390 LEP1GSC102_RS224060 LEP1GSC102_RS224060 LEP1GSC102_RS215975 LEP1GSC102_RS218985 heptose 6- diphosphatase: ATP acetylglutamate anthranilate PRPP 4-phosphate dehydrogenase dehydrogenase a mature peptidoglycan a proteinogenic [+ 10 isozymes] LEP1GSC102_RS211480 reductase: 3-ketoacyl-ACP α D-alanine--D-alanine ligase: (acetyl- a nascent peptidoglycan phenyl-Coβ- 2-phospho-4-(cytidine 5'- an apurinic site 4-trans- a peptide leuB epimerase: rfaD -D-muramoyl- phosphoribosyltransferase 6 6 dihydrolipoyl γ LEP1GSC102_RS208985 3-methyladenine acetyl-CoA myristoyl-CoA acetyl-CoA 1,1'-dihydroxy- (2E,9Z)- β fabG LEP1GSC102_RS211720 kinase: argB 2-oxoglutarate valine--pyruvate E2 protein] N E2 protein] N -S- 5-hydroxy-CTP 5-hydroxy-CMP transferring) pyruvate with (L-alanyl- -D-glutamyl- 2,6-dichloro-3-(glutathion- within DNA undecenoyl-CoA amino acid 2-maleylacetate 8-(methylsulfanyl) ADP-L-glycero- - a cis,cis- reductase: fabG 3-ketoacyl- L-alanyl-γ-D- LEP1GSC102_RS210720 regulatory subunit: 4-(methylsulfanyl)-2-oxobutanoate SAM aspartate- dehydrogenase: (meso-DAP containing) GMP adenosylcobamide diphospho)-2-C-methyl-D-erythritol 5-chloromaleylacetate sulfite menaquinol-11 acrylate β transaminase: -dihydrolipoyl- succinyldihydrolipoyl- E1 component meso-2,6-diaminopimeloyl- S-yl)-hydroquinone neurosporene hexadecenoyl-CoA -2-oxooctanoate D-manno-heptose delta7,19-3- -ketoacyl-ACP synthase: ACP glutamyl-meso-2,6- lipid X LEP1GSC102_RS218200 N-acetyl-L- anthranilate semialdehyde lpdA with GlcNAc terminus 5'-phosphate a (3R)-3- LEP1GSC102_RS219310 reductase: D-alanyl-D-alanine N-acetyl-L- glutamate 5- dehydrogenase: LEP1GSC102_RS216485 L-lysine L-lysine subunit D-alanine) tetrapeptide oxo-C38:2-[acp] diaminopimelate glu phosphoribosyltransferase: trpD S-adenosylmethionine [+ 2 isozymes] hydroxyoctanoyl-[acp] fabG lipid-A-disaccharide 1-(5-phospho- bifunctional glutamate N- glutamate semialdehyde asd alpha: pdhA β-D-ribosyl)-ATP decarboxylase proenzyme: ala synthase: acetyltransferase/amino- 2503 a (3R)-3- UDP-N-acetylmuramoyl- N-(5-phosphoribosyl) LEP1GSC102_RS211825 UTP and CTP dephosphorylation I adenine 3-[(3aS,4S,5R,7aS)-5-hydroxy- 4-methylphenyl an N-formyl-L- 7-carboxy-4-methyl-3,5- 6-cis, 3-oxo- a 5' triphospho- 2-chloro-cis- a [protein]-L- a uridine 13 3-[(3'- a peptide with a 2,3,4-saturated phosphoribosyl-ATP L-aspartate 4- 2-oxoglutarate adenosylcobinamide- a sphingomyelin octanoyl-CoA acetyl-CoA an adenine in DNA DMKH2-10 acetamide a 3-oxopimeloyl- hydroxyacyl-[acyl- tripeptide--D-alanyl- LEP1GSC102_RS218125 acid acetyltransferase ArgJ: -anthranilate in 23S rRNA 7a-methyl-1-oxo-octahydro-1H- ribotide methionylaminoacyl- dioxoheptanoyl-CoA tridecenoyl-CoA [mRNA] dienelactone proline (ω = 180) in tRNA methylsulfanyl) an N-terminal fatty acyl-[acp] pyrophosphatase: N-acetylornithine 1,2-dihydroxy-5- semialdehyde alanine dehydrogenase subunit E1: a [pyruvate dehydrogenase a [pyruvate dehydrogenase GDP [acp] methyl ester carrier protein] lipid A disaccharide LEP1GSC102_RS223075 6 23S rRNA inden-4-yl]-3-oxopropanoyl-CoA phosphate tRNA acetyl-CoA C- acetyl-CoA C- sphingomyelin acetyl-CoA C- propyl]malate L-methionine D- alanine ligase: aminotransferase: phosphoribosylanthranilate dAdoMet UTP E2 protein] N - E2 protein] N 6 -S- acetyl-CoA C- adenosylcobinamide- peptide deformylase: N-6 adenine-specific peptidylprolyl isomerase: tRNA pseudouridine(13) demethylmenaquinone type I methionyl 3-ketoacyl- (E. coli) hisE (methylsulfanyl)pent-1-en-3-one homoserine dehydrogenase: racemase: alr LEP1GSC102_RS218620 (adenine(2503)-C(2) acyltransferase: acyltransferase: phosphodiesterase: sph acyltransferase: RNA pyrophosphohydrolase: dienelactone hydrolase: amidase: 3-isopropylmalate a (2E)-oct-2-enoyl-[acp] LEP1GSC102_RS219440 gln LEP1GSC102_RS211135 isomerase: dihydrolipoyl-L-lysine acetyldihydrolipoyl-L-lysine acyltransferase: GDP ribazoletransferase: LEP1GSC102_RS207880 DNA methylase: LEP1GSC102_RS214170 synthase TruD: methyltransferase: aminopeptidase: ACP 1-(5-phospho-β- putrescine LEP1GSC102_RS222595 dihydrolipoyllysine-residue )-methyltransferase LEP1GSC102_RS210020 LEP1GSC102_RS210020 [+ 3 isozymes] LEP1GSC102_RS210020 LEP1GSC102_RS222710 LEP1GSC102_RS224060 LEP1GSC102_RS218985 dehydrogenase: tetraacyldisaccharide bifunctional glutamate N- LEP1GSC102_RS211115 CTP 3-[(3aS,4S,5RLEP1GSC102_RS210020,7aS)-5-hydroxy- LEP1GSC102_RS224485 a L-methionylaminoacyl- LEP1GSC102_RS221295 [+ 5 isozymes] LEP1GSC102_RS212975 LEP1GSC102_RS211480 map reductase: D-ribosyl)-AMP acireductone spermidine synthase: D-ala succinyltransferase: RlmN: rlmN 4-methylphenyl-Co formate 5-carboxy-2-methyl- 4-cis- 3-oxodecanoyl- leuB UDP-N-acetyl- 4'-kinase: lpxK carbamoyl-phosphate acetyltransferase/amino- 1-(2-carboxyphenylamino) synthetase: acetyl-CoA 7a-methyl-1-oxo-octahydro- tRNA acetyl-CoA acetyl-CoA phosphocholine a ceramide a 5'-phospho- an N 6 -methyladenine a [protein]-L- a pseudouridine 13 a peptide met fabG N-acetyl-L- synthase: mtnC LEP1GSC102_RS221845 LEP1GSC102_RS218610 2503 GMP β-adenosylcobamide 3-oxopentanoyl-CoA undecenoyl-CoA CoA 2-chloromaleylacetate menaquinol-10 acetate 6-(methylsulfanyl) a (3R)-3- α-D-muramoyl- phosphoribosyl-AMP acid acetyltransferase ArgJ: -1-deoxy-D-ribulose L-homoserine pyrG a 2-methyladenine ω lipid IV synthase small chain: ornithine spermidine UMP 5'-deoxyadenosine met 1H-indene-4-carboxyl-CoA 5'-phosphate [mRNA] in DNA proline ( = 0) in tRNA -2-oxohexanoate hydroxypimeloyl- a trans-2- L-alanyl-γ-D- A cyclohydrolase: LEP1GSC102_RS223075 5-phosphate lipoate in 23S rRNA a 2,3,4-saturated LEP1GSC102_RS218655 2-hydroxy-5-(methylsulfanyl)- acetate [acp] methyl ester enoyl-[acyl- glutamyl-meso-2,6- di-trans,octa-cis LEP1GSC102_RS220315 indole-3-glycerol S-methyl-5'-thioadenosine CTP 5'-nucleotidase acetyltransferase: fatty acyl-[acp] carbamoyl-phosphate L-lysine biosynthesis VI 3-oxopent-1-enyl 1-phosphate acetyl-CoA conversion an octanoyl-[acp] carrier protein] diaminopimeloyl- -undecaprenyl 1-(5-phospho-β-D-ribosyl)- phosphate synthase TrpC: S-methyl-5'- SurE: surE pdhA 5-[(5-phosphoribosylamino) synthase large subunit: thioadenosine to acetyl-CoA decaprenyl-diphospho-N- UDP-N-acetyl- an N-terminal- an N-terminal- D-alanyl-D-alanine phosphate LEP1GSC102_RS209985 S-adenosyl-L-methionine cycle II uridine an N 10 - an L-methionyl- 2-amino-6-[1-hydroxyethyl]- 3-(4-hydroxyphenyl)- 9-carboxy-6-methyl-3,7- 3-oxo-(11Z)- 2-methylacetoacetyl- 3-oxo-(5Z)- (R)-methylmalonyl- a supercoiled (2R,3S)-3- a 3-oxoglutaryl- β-ketodecanoyl- methylideneamino]imidazole- LEP1GSC102_RS210445 acireductone phosphorylase: mtnP acetate acetylmuramoyl-pentapeptide α-D-glucosamine 4-nitrocatecholsulfate 5-aminolevulinate D-threo-isocitrate wound RNA L-methionyl-L- L-methionyl- asp (1S,2R)-1-C-(indol-3- synthase: mtnC formyltetrahydrofolate [initiator tRNA Met ] 7-methyl-7,8-dihydropterin 3-oxo-propanoyl-CoA dioxononanoyl-CoA octadecenoyl-CoA CoA tetradecenoyl-CoA CoA duplex DNA isopropylmalate [acp] methyl ester [acp] synthase: 4-carboxamide carbamoyl CMP acetate- undecaprenyldiphospho- methionyl-tRNA 2-amino-4-hydroxy-6- acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- methylmalonyl-CoA mutase: isocitrate dehydrogenase helicase: alanyl-[protein]type I methionyl glycyl-[protein]type I methionyl 3-isopropylmalate 3-ketoacyl- L-ornithine aspartate kinase: yl)glycerol 3-phosphate sulfatase: porphobilinogen synthase: RNA helicase: LEP1GSC102_RS219310 1-(5-phosphoribosyl) phosphate met -CoA muramoylpentapeptide beta-N- formyltransferase: hydroxymethyldihydropteridine acyltransferase: acyltransferase: acyltransferase: acyltransferase: acyltransferase: LEP1GSC102_RS211670 (NADP(+)): LEP1GSC102_RS211030 aminopeptidase: aminopeptidase: dehydrogenase: ACP LEP1GSC102_RS208665 5-(methylsulfanyl)-2,3- S-adenosylmethionine 5'-nucleotidase LEP1GSC102_RS210450 LEP1GSC102_RS212070 LEP1GSC102_RS209390 undecaprenyldiphospho- -5-((5- tryptophan synthase: 5-MTR-1-P ligase: acs acetylglucosaminyltransferase: LEP1GSC102_RS208075 diphosphokinase: folK LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS210020 [+ 2 isozymes] LEP1GSC102_RS223215 [+ 2 isozymes] map map leuB reductase: a 3-oxodecanoyl-[acp] L-aspartyl- dioxopentyl 1-phosphate S-methyl-5-thioribose- synthase: SurE: surE an N-formyl- 7-carboxy-4-methyl- (3Z)-dodec- N-acetylmuramoyl-L- phosphoribosylamino) LEP1GSC102_RS221030 trpB acetyl-CoA LEP1GSC102_RS210675 [1-(2-amino-7-methyl-4-oxo- acetyl-CoA 4-hydroxybenzoyl-CoA acetyl-CoA palmitoleoyl-CoA acetyl-CoA acetyl-CoA propanoyl-CoA acetyl-CoA a single an N-terminal L- an N-terminal 4-methyl-2- fabG 4-phosphate methylthioribulose 1-phosphate LEP1GSC102_RS213775 decaprenyl-pyrophosphoryl- L-methionyl- a tetrahydrofolate 5-oxoheptanoyl-CoA 3-enoyl-CoA succinyl-CoA 4-nitrocatechol porphobilinogen 2-oxoglutarate an unwound RNA met met a (3R)-3- γ tryptophan cytidine met 7,8-dihydro-3H-pteridin- alanyl-[protein] glycyl-[protein] alanyl- -D-glutamyl-meso methylideneamino) 1-phosphate isomerase: mtnA methionine synthase: UDP (N-acetylglucosamine)-N- [initiator tRNA ] stranded DNA oxopentanoate hydroxyglutaryl- 3-ketoacyl-ACP synthase 6-yl)]ethyl diphosphate -2,6-diaminopimeloyl- imidazole-4- ornithine aspartate- dehydratase: mtnB LEP1GSC102_RS212460 acetylmuramyl-(pentapeptide) [acp] methyl ester reductase: fabG biotin-carboxyl carrier protein assembly D-alanyl-D-alanine carboxamide carbamoyltransferase: semialdehyde subunit beta: trpB undecaprenyldiphospho- isomerase: hisA LEP1GSC102_RS220785 dehydrogenase: ser a (3R)-3- a [biotin carboxyl- indole 5-(methylsulfanyl)- UDP-N-acetyl-α-D-muramoyl- 2-bromo-3-(4- 3-oxo-(7Z)- 3-oxopentanoyl- β-D-fructofuranose (5Z)- an N-terminal- (2R,3S)-3- hydroxydecanoyl-[acp] muramoylpentapeptide beta-N- phosphoribulosylformimino- asd ribulose 1-phosphate L-homocysteine SAM D-alanyl-D-alanine acetoacetate glutathione 2-oxoglutarate 2-oxoadipate isovalerate uroporphyrinogen-I cis-vaccenoyl-CoA citrate ethanol phytol a 3-oxoicosanoyl- carrier protein]-L-lysine acetylglucosaminyltransferase: superpathway of L-serine L-alanyl-γ-D-glutamyl-L-lysine nitrophenyl)propanoate tetradecenoyl-CoA CoA 1-phosphate dodecenoyl-CoA L-methionyl-L- isopropylmalate AICAR-phosphate L-aspartate 4- glutathione S-transferase: 2-oxoglutarate 2-oxoglutarate acetyl-CoA C- acetyl-CoA C- fructose-bisphosphate [acp] biotin--[acetyl-CoA- LEP1GSC102_RS210675 tryptophan and glycine biosynthesis I UDP-N-acetylmuramoyl- acetoacetate--CoA ligase: acetate--CoA uroporphyrinogen acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: NAD(P)-dependent valyl-[protein]type I methionyl NAD(P)-dependent 3-isopropylmalate 3-ketoacyl- semialdehyde LEP1GSC102_RS213820 dehydrogenase subunit E1: dehydrogenase subunit E1: acyltransferase: acyltransferase: aldolase: aconitate hydratase: carboxylase] ligase: lipid II (meso synthase tripeptide--D-alanyl- LEP1GSC102_RS218420 ligase: acs decarboxylase: LEP1GSC102_RS216110 LEP1GSC102_RS216110 alcohol dehydrogenase: aminopeptidase: alcohol dehydrogenase: dehydratase: ACP imidazole glycerol 4-hydroxy- 3-phospho-D-glycerate L-cysteine biosynthesis I D- alanine ligase: glutathione S-transferase: LEP1GSC102_RS218620 LEP1GSC102_RS218620 LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS219700 LEP1GSC102_RS211875 LEP1GSC102_RS210015 diaminopimelate L-citrulline subunit beta: trpB (5Z)- LEP1GSC102_RS212090 [+ 10 isozymes] [+ 10 isozymes] LEP1GSC102_RS221190 map LEP1GSC102_RS221190 leuD leuC reductase: phosphate synthase tetrahydrodipicolinate phosphoglycerate LEP1GSC102_RS219440 AMP diphosphate acetoacetyl-CoA LEP1GSC102_RS208985 NADH CO succinyl-CoA glutaryl-CoA NADH CO acetyl-CoA propanoyl-CoA acetyl-CoA isovaleryl-CoA AMP diphosphate an N-terminal containing) α 2 2 D-glyceraldehyde DHAP (2E,11Z)- (2E,5Z)- met (2S)-2- fabG a (2E)-dec-2-enoyl-[acp] a [biotin carboxyl-carrier L-valine biosynthesis dehydrogenase: adenosylhomocysteinase: UDP-N-acetyl- -D-muramoyl-L-alanyl- 2-(glutathion-S-yl)-3-(4- dodecenoyl-CoA coproporphyrinogen I D-threo-isocitrate acetaldehyde phytenal a (3R)-3- 6 cyclase subunit: synthase: bromide L-valyl-[protein] protein]-N -biotinyl-L-lysine argininosuccinate synthase: LEP1GSC102_RS212450 γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine nitrophenyl)propanoate octadecenoyl-CoA dodecenoyl-CoA isopropylmalate hydroxyicosanoyl- LEP1GSC102_RS221550 LEP1GSC102_RS220945 trp LEP1GSC102_RS225385 ser LEP1GSC102_RS222840 (2S,4S)-4- 3-phosphooxypyruvate SAH [acp] imidazole pyruvate serine O- L-arginino- hydroxy-2,3,4,5- acetolactate synthase: glycerol 3-phosphoserine acetyltransferase: cysE a [biotin carboxyl- succinate tetrahydrodipicolinate LEP1GSC102_RS214035 ilvB 2-phospho-4-(cytidine 5'- 2,3,5,6- 5-amino-4- 5-cis, 7-trans-3-oxo- 4-trans-3-oxo- (5E)-3-oxo- RNase III mRNA (7Z)- a (9Z)-3- phosphate aminotransferase: O-acetyl-L-serine a sulfurated glutathione PRPP acetyl-CoA 4-hydroxybutanoate a 3-oxoacyl-CoA cis-dienelactone (E)-2-hexenol butan-1-ol AsbD acyl- precorrin-3B a decanoyl-[acp] carrier-protein dimer]- argininosuccinate 4-hydroxy- L-leucine biosynthesis acetolactate SAM dethiobiotin diphospho)-2-C-methyl-D-erythritol tetrachlorohydroquinone imidazolecarboxyamide tetradecadienoyl-CoA undecenoyl-CoA dodec-5- processing tetradecenoyl-CoA L-saccharopine coenzyme A oxohexadec- 6 synthase LEP1GSC102_RS224020 [sulfur carrier] 2-C-methyl-D-erythritol 2,4- carrier protein N -biotinyl-L-lysine tetrahydrodipicolinate biotin glutathione S-transferase: adenine 4-hydroxybutyrate acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- enoyl-CoA substrate acyl-CoA dehydrogenase: saccharopine NAD(P)-dependent NAD(P)-dependent holo-ACP precorrin-3B C(17)- 9-enoyl-[acp] subunit lyase: argH synthase, large O-acetylhomoserine cyclodiphosphate synthase: acetyl-CoA C- ribonuclease dienelactone hydrolase: 3-ketoacyl- β-ketododecanoyl- acetyl-CoA carboxylase reductase: 3-methyl-2- synthase LEP1GSC102_RS213820 phosphoribosyltransferase: CoA-transferase: acyltransferase: acyltransferase: acyltransferase: LEP1GSC102_RS216110 dehydrogenase: alcohol dehydrogenase: alcohol dehydrogenase: synthase: methyltransferase: biotin carboxylase: HisH: hisH subunit, biosynthetic O-phospho-L-serine aminocarboxypropyltransferase/ LEP1GSC102_RS222440 acyltransferase: 3: rnc LEP1GSC102_RS224060 ACP [acp] synthase: biotin carboxylase subunit: LEP1GSC102_RS220950 oxobutanoate type: ilvB BioB: bioB glutathione S-transferase: LEP1GSC102_RS212735 LEP1GSC102_RS211600 LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS210020 RNase III [+ 10 isozymes] LEP1GSC102_RS213975 LEP1GSC102_RS221190 LEP1GSC102_RS221190 acpS cobJ reductase: LEP1GSC102_RS213705 arg 2-isopropylmalate synthase: cysteine synthase: 2-C-methyl-D-erythritol- 4-hydroxybutanoyl- (3Z,5E)-dodeca- 2-trans- LEP1GSC102_RS219310 LEP1GSC102_RS214740 D-erythro- (S)-2,3,4,5- (S)-2-acetolactate an unsulfurated CMP LEP1GSC102_RS208985 AICAR acetate acetyl-CoA acetyl-CoA acetyl-CoA an acyl-CoA acetyl-CoA (3E)-dec-3- an mRNA fragment processing (2E,7Z)- a holo-[AsbD acyl- fabG [+ 2 isozymes] LEP1GSC102_RS221975 phosphoserine LEP1GSC102_RS210735 met 5'-deoxyadenosine biotin 2,4-cyclodiphosphate 2,3,5-trichloro-6-(glutathion- CoA 3,5-dienoyl-CoA nonenoyl-CoA allysine glu 2-maleylacetate (E)-2-hexenal butan-1-al 3',5'-ADP precorrin-4 a (3R,9Z)-3- [+ 2 isozymes] AICAR imidazole-glycerol- tetrahydrodipicolinate [sulfur carrier] enoyl-CoA product mRNA tetradecenoyl-CoA carrier protein] a 3-oxododecanoyl-[acp] (2S)-2- [+ 2 isozymes] phosphatase SerB: serB cysteine synthase A: cysK S-yl)-hydroquinone hydroxyhexadec- a [carboxyl-carrier phosphate LL-diaminopimelate ketol-acid reductoisomerase: 9-enoyl-[acp] protein dimer]-N 6 - imidazoleglycerol- aminotransferase: isopropylmalate LEP1GSC102_RS224325 cys 3-ketoacyl-ACP carboxybiotinyl-L-lysine 3-isopropylmalate ser phosphate dehydratase: L-proline biosynthesis I LEP1GSC102_RS210235 (2R)-2,3-dihydroxy- L-threonine 34 a peptidoglycan 2''-O-acetyl- γ a (7Z)-3- reductase: fabG LEP1GSC102_RS217710 dehydratase: a single a 5-carboxymethylaminomethyluridine 3-oxo-(7Z)- CMP-Kdo lipid IV 3-oxooctanoyl- 3-oxo- dihomo - (5Z)- 3,22-dioxochol- (6E)-8- an apo-[aryl- biosynthesis 3-methylbutanoate A H O MeOH butan-1-ol 3-ethylmalate L,L- leuD leuC serine stranded DNA in tRNA Leu dimer (generic) hexadecenoyl-CoA CoA myristoyl-CoA ADP-ribose linolenoyl-CoA 2 tetradecenoyl-CoA 4-en-24-oyl-CoA hydroxygeranial coenzyme A oxohexacos- 2,3-dihydroxy- L-methionine biosynthesis III ATP cob(II)alamin lytic transglycosylase 3-deoxy-D-manno- O-acetyl-ADP- carrier protein] a (3R)-3- imidazole acetol- diaminopimelate hydroxymethyltransferase: glyA exodeoxyribonuclease VII: tRNA (cytidine(34)-2'- acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- acyl-CoA thioesterase: acyl-CoA dehydrogenase: acetyl-CoA C- NAD(P)-dependent NAD(P)-dependent holo-ACP 3-isopropylmalate 7-enoyl-[acp]3-ketoacyl- glu isovalerate domain-containing protein: octulosonic acid transferase: ribose deacetylase: catalase: hydroxydodecanoyl-[acp] phosphate L-homoserine 2-isopropylmaleate LEP1GSC102_RS208245 cob(I)yrinic acid a,c-diamide O)-methyltransferase: acyltransferase: acyltransferase: acyltransferase: LEP1GSC102_RS222175 LEP1GSC102_RS223025 acyltransferase: alcohol dehydrogenase: alcohol dehydrogenase: synthase: dehydrogenase: ACP glutamate 5- diaminopimelate epimerase: dehydratase: ilvD LEP1GSC102_RS208240 LEP1GSC102_RS211865 LEP1GSC102_RS210020 LEP1GSC102_RS219485 LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS222960 LEP1GSC102_RS225205 histidinol-phosphate gly L-homoserine adenosyltransferase: cobO LEP1GSC102_RS208815 α-Kdo-(2->6) [+ 4 isozymes] [+ 10 isozymes] LEP1GSC102_RS210020 LEP1GSC102_RS221190 LEP1GSC102_RS221190 acpS leuB reductase: kinase: proB homoserine LEP1GSC102_RS217535 3-isopropylmalate a single-stranded a ribonucleoside GlcNAc-1,6-anhydro- (5Z)- CMP di-homo-γ- transaminase: γ homoserine O- triphosphate adenosylcobalamin a 5-carboxymethylaminomethyl- a lipid II acetyl-CoA -lipid IV acetyl-CoA hexanoyl-CoA acetyl-CoA lauroyl-CoA acetate ADP-D-ribose (2E,5Z)- 3-oxo-4-pregnene- (6E)-8- a holo-[aryl- fabG -L-glutamyl kinase: thrB dehydratase: 3-methyl-2-oxobutanoate oligodeoxyribonucleotide 5'-monophosphate MurNAc-pentapeptide tetradecenoyl-CoA A linolenate 3',5'-ADP a (3R,7Z)-3- 34 Leu formaldehyde butan-1-al carrier protein] 2-oxovalerate LEP1GSC102_RS218460 5-phosphate O-phospho- meso- leuD leuC acetyltransferase: 2'-O-methyluridine in tRNA tetradecenoyl-CoA 20-carboxyl-CoA oxogeranial hydroxyhexacos- L-histidinol L-homoserine diaminopimelate branched-chain amino LEP1GSC102_RS210730 7-enoyl-[acp] a (2E)-dodec-2-enoyl-[acp] glutamate-5-semialdehyde (2R,3S)-3- acid transaminase: hydrogen sulfide O-acetyl-L- phosphate dehydrogenase: threonine diaminopimelate isopropylmalate homoserine synthase: LEP1GSC102_RS217170 LEP1GSC102_RS209920 decarboxylase: 3-isopropylmalate O-acetylhomoserine a [glycine-cleavage 3-oxo-2-(cis-2'-pentenyl)- 3-oxo-(9Z)- 3-oxododecanoyl- S-(2-hydroxyacyl) 3''-O-acetyl- an apo-[LYS2 L- a (5Z)-3- thrC an L-phenylalanyl- an N-terminal a proteinogenic palmitoyl-CoA H O oleoyl-CoA reduced riboflavin decanoyl-CoA ethanol [EntF L-seryl- precorrin-2 LEP1GSC102_RS214355 dehydrogenase: SAM complex H protein] a sulfurated [sulfur carrier] glutathione glutathione hypoglycin A ADP-ribose 2 2-aminoadipyl- coenzyme A coenzyme A oxotetracos- L-glutamate-5- val aminocarboxypropyltransferase/ cyclopentane-1-(3-oxohexanoyl)-CoA [tRNA Phe ] arginyl-[protein] amino acid octadecenoyl-CoA CoA glutathione carrier protein] leuB N 6 -octanoyl-L-lysine acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- hydroxyacylglutathione O-acetyl-ADP- acyl-CoA thioesterase: carrier-protein] 5-enoyl-[acp] semialdehyde thr cysteine synthase: lipoyl leucyl/phenylalanyl-tRNA- gamma- gamma- acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: holo-ACP holo-ACP precorrin-2 C(20)- 3-ketoacyl- histidinol lys acyltransferase: acyltransferase: acyltransferase: hydrolase: ribose deacetylase: LEP1GSC102_RS218555 flavin reductase: catalase: a dodecanoyl-[acp] (2S)-2-isopropyl- LEP1GSC102_RS210735 synthase: lipA -protein transferase: glutamyltransferase: ggt glutamyltransferase: ggt LEP1GSC102_RS216110 LEP1GSC102_RS216110 synthase: synthase: methyltransferase: ACP a [glycine-cleavage LEP1GSC102_RS210020 α γ LEP1GSC102_RS210020 LEP1GSC102_RS210020 LEP1GSC102_RS210975 LEP1GSC102_RS222960 LEP1GSC102_RS225735 LEP1GSC102_RS225205 3-oxosuccinate an unsulfurated LEP1GSC102_RS217640 an -( -L-glutamyl) [+ 4 isozymes] [+ 10 isozymes] [+ 10 isozymes] a holo-[LYS2 L- acpS a acpSholo-[EntF cobI reductase: histidinol 5'-deoxyadenosine met complex H protein] 3-oxo-2-(cis-2'-pentenyl)- L-phenylalanyl-L- L-cysteinylglycine (7Z)- L-cysteinylglycine hypoglycin B a 2-hydroxy L-homocysteine acetyl-CoA Phe -L-amino acid acetyl-CoA acetyl-CoA decanoyl-CoA glutathione acetate ADP-D-ribose palmitate (2E,9Z)- (2E)-dec-2- fabG dehydrogenase: glycine biosynthesis II [sulfur carrier] 6 cyclopentane-1-butanoyl-CoA a tRNA hexadecenoyl-CoA carboxylate 2-aminoadipyl- 3',5'-ADP 3',5'-ADP L-seryl-carrier a (3R,5Z)-3- β N -lipoyl-L-lysine arginyl-[protein] riboflavin acetaldehyde precorrin-3A -ketomeristoyl- hisD (S)-1-pyrroline- octadecenoyl-CoA enoyl-CoA carrier-protein] protein] hydroxytetracos- [acp] synthase: 5-carboxylate a [glycine-cleavage methionine synthase: methionine synthase: L-alanine biosynthesis III 4-methyl-2- 5-enoyl-[acp] LEP1GSC102_RS219310 histidinal pyrroline-5- gly complex H protein] LEP1GSC102_RS212460 LEP1GSC102_RS212460 laurate 6 oxopentanoate carboxylate N -lipoyl-L-lysineglycine histidinol branched-chain amino α-Kdo-(2-> RNase R degradation (+)-7-epi- a long-chain 20 (indol-3-yl) an N-terminal-L-methionyl- an (11Z)-3- reductase: cys dehydrogenase met an L-arginyl- an N-terminal L- 3-oxo-2-(cis-2'-pentenyl)- a [protein]- (4S)-4-hydroxy-2- H O H O a 5,6-dihydrouracil [EntB aryl- long-chain fatty α a [protein]-L-lysine asp fumarate butanoyl-CoA acetyl-CoA 2 2 myristoyl-CoA an aryl sulfate precorrin-4 a 3-oxotetradecanoyl-[acp] dehydrogenase: acid transaminase: Arg a dodecanoyl-[acp] 4)- -Kdo-(2- substrate RNA jasmonoyl-CoA fatty acyl-CoA acetamide L-threonyl-[protein] coenzyme A oxooctadec- proC (aminomethyl- [tRNA ] glutamyl-[protein] cyclopentane-1-(3-oxooctanoyl)-CoA L-glutamine oxoheptanedioate in tRNA carrier protein] acid--CoA ligase: hisD cysteine desulfurase: LEP1GSC102_RS217170 acetyl-CoA C- >6)-lipid IV ribonuclease R: transglutaminase: acetyl-CoA C- 2,4-dihydroxyhept-2-ene- acyl-CoA thioesterase: acyl-CoA thioesterase: type I methionyl 11-enoyl-[acp] transferring): gcvP A L-aspartate oxidase: tRNA dihydrouridine(20/ acyl-CoA dehydrogenase: holo-ACP precorrin-4 C(11)- 3-ketoacyl- LEP1GSC102_RS209125 LEP1GSC102_RS222330 arginyl-tRNA-protein transferase: acyltransferase: lauroyl acyltransferase: LEP1GSC102_RS217345 acyltransferase: 1,7-dioic acid aldolase: LEP1GSC102_RS222175 LEP1GSC102_RS218555 amidase: sulfatase: aminopeptidase: 3-ketoacyl-ACP LEP1GSC102_RS220060 LEP1GSC102_RS219620 20a) synthase DusA: LEP1GSC102_RS216110 synthase: methyltransferase: ACP [+ 3 isozymes] pro [+ 2 isozymes] an N-terminal LEP1GSC102_RS2000000229490 LEP1GSC102_RS210020 LEP1GSC102_RS209380α-Kdo-(2->4)- a nucleoside 5'- a protein with an LEP1GSC102_RS210020 LEP1GSC102_RS224680 [+ 4 isozymes] [+ 4 isozymes] LEP1GSC102_RS218985 LEP1GSC102_RS210450 map his ala CO leu a diribonucleotide 6 γ LEP1GSC102_RS222275 [+ 10 isozymes] acpS cobM reductase: reductase: fabG 2 Arg 3-oxo-2-(cis-2'-pentenyl)- N -( -glutamyl)- succinate 2-iminosuccinate 3-oxohexanoyl- succinate (+)-7-epi- a long-chain L-arginiyl-L- a tRNA acetyl-CoA acyl-carrier protein α-Kdo-(2->6)- monophosphate pyruvate an N-terminal L- a holo-[EntB aryl- lauroyl-CoA cyclopentane-1-hexanoyl-CoA L-lysine crosslink CoA semialdehyde jasmonate fatty acid 20 2E)-tetradec- met 3',5'-ADP a (3R,11Z)-3-fabG a (3R)-3- glutamyl-[protein] (lauroyl)-lipid IV a uracil in tRNA (indol-3-yl)acetate a phenol threonyl-[protein] carrier protein] precorrin-5 A 2-enoyl-CoA hydroxyoctadec- hydroxytetradecanoyl-[acp] 11-enoyl-[acp]

Nucleoside and Nucleotide Biosynthesis 5,10-methylene- 3-methyl-2- (6Z,9Z,12Z,15Z,18Z,21Z)-3- a 1-(1-alkenyl) 2,3-bis-O- (R)-S- 3-oxo-(5Z)- UDP-N-acetyl- an L-arginyl- an N-terminal L- a proteinogenic stearoyl-CoA H O a uridine in tRNA α a single a ribonucleoside propionamide D-mannitol DMKH NaMN phosphatidylglycerol -sn-glycero-3- leukotriene-C4 (geranylgeranyl)-sn- CTP H O diphosphate 2 -D-glucosamine 2 a protein [tRNA Arg ] tetrahydromethanopterin oxobutanoate oxotetracosahexaenoyl-CoA amino acid 2 lactoylglutathione dodecenoyl-CoA stranded DNA triphosphate aspartyl-[protein] 3-methyl-2-oxobutanoate acetyl-CoA C- phosphocholine glycerol 1-phosphate hydroxyacylglutathione acetyl-CoA C- acyl-CoA thioesterase: UDP-N-acetylglucosamine a (2E)-tetradec-2-enoyl-[acp] biosynthesis II (non-plastidic) arginyl-tRNA-protein transferase: lysoplasmalogenase: gamma- CDP-archaeol synthase: inorganic pyrophosphatase: tRNA dihydrouridine DNA NAD(P)-dependent demethylmenaquinone UMP biosynthesis II guanine and guanosine salvage hydroxymethyltransferase: acyltransferase: hydrolase: acyltransferase: LEP1GSC102_RS218555 2-epimerase (non- amidase: 5'-nucleotidase superpathway of guanosine inosine-5'-phosphate biosynthesis I superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis III 5-aminoimidazole inosine-5'-phosphate biosynthesis II pyrimidine deoxyribonucleotide phosphorylation LEP1GSC102_RS2000000229490 LEP1GSC102_RS211655 glutamyltransferase: ggt LEP1GSC102_RS221005 LEP1GSC102_RS209375 synthase DusB: primase: alcohol dehydrogenase: methyltransferase: endopeptidase DHAP adenosine nucleotides an N-terminal panB LEP1GSC102_RS210020 sn-glycero-3- an α-(γ-L-glutamyl) unsaturated LEP1GSC102_RS210975 LEP1GSC102_RS210020 [+ 4 isozymes] hydrolyzing): dnaG LEP1GSC102_RS218985 LEP1GSC102_RS221190 SurE: surE nucleotides de novo biosynthesis I ribonucleotide biosynthesis II + LEP1GSC102_RS217210 LEP1GSC102_RS211480 La: lon glycerol-3-phosphate dTMP dCMP L-arginiyl-L- a tRNA Arg (4Z,7Z,10Z,13Z,16Z,19Z) a fatty aldehyde leukotriene-D4 phosphate H (3Z)-dec-3- LEP1GSC102_RS224780 ssDNA/pppN(pN) aldehydo- gln hydrogencarbonate AIR de novo biosynthesis I UDP CTP THMPT 2-dehydropantoate acetyl-CoA phosphocholine -L-amino acid CDP-archaeol (R)-lactate glutathione acetyl-CoA stearate a 5,6-dihydrouridine UDP-N-acetyl-α- β-D- dehydrogenase (NAD(P)(+) AIR thymidylate cytidylate kinase: aspartyl-[protein] -docosahexaenoyl-CoA enoyl-CoA hybrid propanoate D-mannose MQH 5-(carboxyamino)imidazole ribonucleoside- PRPP guanosine in tRNA D-mannosamine n -1 2 ribosylnicotinate a peptide ): LEP1GSC102_RS213435 5-(carboxyamino)imidazole kinase: tmk LEP1GSC102_RS218740 carbamoyl-phosphate IMP ribonucleotide synthase: asp IMP diphosphate reductase, amidophosphoribosyltransferase: a myristoyl-[acp] sn-glycerol CDP ribonucleotide synthase: dTDP dCDP synthase small chain: LEP1GSC102_RS219430 adenylosuccinate adenosylcobalamin- LEP1GSC102_RS223120 3-phosphate β LEP1GSC102_RS219430 β-ketopalmityl- LEP1GSC102_RS218655 IMP N5-CAIR synthetase: dependent: ribonucleoside- 5-phospho- - nucleoside- nucleoside- glycerol-3-phosphate CAIR an N-terminal 13-sophorosyloxydocosanoate 3-oxo-2-(cis-2'-pentenyl)- an (R)-2- a single- a sophorosyloxyfatty lysine within D-firefly (S)-4-amino-5- (3Z)-hex- CDP-α-D-glucose [acp] synthase: carbamoyl-phosphate dehydrogenase: LEP1GSC102_RS218195 LEP1GSC102_RS208230 diphosphate reductase, D-ribosylamine guanine diphosphate kinase: diphosphate kinase: an L-arginyl- O-ureido-L- (R)-lipoate [DNA] H O D-galactopyranose GDP-β-L-fucose oxaloacetate pyridoxamine 3-sulfino-L- asp 2 VibB coenzyme A acyltransferase: guaB adenylo-succinate dUDP phosphoribosylamine- LEP1GSC102_RS222830 LEP1GSC102_RS222830 Arg 6',6''-diacetate cyclopentane-1-(3-oxobutanoyl)-CoA halocarboxylate stranded RNA acid O(6'')-acetate gcv protein H luciferyl-CoA oxopentanoate 3-en-1-ol CDP- 5'-phosphate LEP1GSC102_RS219310 synthase large subunit: 5-(carboxyamino)imidazole adenosylcobalamin- phosphoribosylaminoimidazolesuccinocarboxamide [tRNA ] acetylesterase: acetyl-CoA C- polyribonucleotide homoserine exodeoxyribonuclease acyl-CoA thioesterase: LEP1GSC102_RS218880 -glycine ligase: alanyl-[protein] HAD family hydrolase: acetylesterase: argininosuccinate synthase: lipoate--protein ligase: glutamate-1-semialdehyde NAD(P)-dependent phosphoenolpyruvate glucose 4,6- pyridoxine/ LEP1GSC102_RS210445 ribonucleotide mutase: purE nucleoside- dependent: synthase: LEP1GSC102_RS215020 hypoxanthine dTTP dCTP arginyl-tRNA-protein transferase: LEP1GSC102_RS225230 acyltransferase: nucleotidyltransferase: pnp III: xth LEP1GSC102_RS222175 galactose oxidase: GDP-L-fucose synthase: holo-ACP [+ 2 isozymes] XMP adenylosuccinate lyase: LEP1GSC102_RS216700 β β LEP1GSC102_RS214620 LEP1GSC102_RS225230 LEP1GSC102_RS222840 LEP1GSC102_RS219240 2,1-aminomutase: alcohol dehydrogenase: carboxykinase dehydratase: pyridoxamine a 3-oxohexadecanoyl-[acp] diphosphate kinase: LEP1GSC102_RS208230 phosphoribosyltransferase: hpt an N-terminal L- LEP1GSC102_RS2000000229490 13-[O(2')- -D-glucopyranosyl- -D- LEP1GSC102_RS210020 an (S)-2- a nucleoside a single- a sophorosyloxyfatty a [glycine-cleavage a 2'- [+ 4 isozymes] LEP1GSC102_RS210240 LEP1GSC102_RS219840 synthase: acpS a 1-acyl-sn carbamoyl CAIR LEP1GSC102_RS215520 SAICAR acetate glucopyranosyloxy]docosanoate a halide anion acetate canavaninosuccinate complex H protein] deoxyribonucleoside [DNA] LEP1GSC102_RS212075 LEP1GSC102_RS221190 a holo-[VibB aryl- (ATP): pckA rfbG 5'-phosphate asp LEP1GSC102_RS222830 dCDP arginiyl-3-sulfino- a tRNA Arg hydroxycarboxylate diphosphate stranded RNA acid GDP-4-dehydro- 3',5'-ADP -glycerol 3- phosphate glutamine-hydrolyzing GAR acetyl-CoA (+)-7-epi-jasmonoyl-CoA 6 D-firefly luciferin D-galacto- carrier protein] phosphoenol CDP-4-dehydro-6- oxidase: pdxH 3-ketoacyl-ACP L-alanyl-[protein] O(6'')-acetate N -lipoyl-L-lysine 5'-monophosphate 5-aminolevulinate α-D-rhamnose (Z)-3-hexanal phosphate GMP synthase: phosphoribosylaminoimidazolesuccinocarboxamide dUTP nucleoside- GMP hexodialdose pyruvate deoxy-α-D-glucose PLP reductase: fabG 1-acyl-sn-glycerol-3- aspartate AMP phosphoribosylglycinamide adenylosuccinate lyase: LEP1GSC102_RS210830 synthase: LEP1GSC102_RS215020 diphosphate kinase: phosphate acyltransferase: carbamoyltransferase: dUTP diphosphatase: formyltransferase 2: LEP1GSC102_RS215520 UTP and CTP de a (3R)-3- pyrB LEP1GSC102_RS218220 LEP1GSC102_RS222830 LEP1GSC102_RS216765 LEP1GSC102_RS214745 SAICAR adenylate kinase: AICAR novo biosynthesis hydroxyhexadecanoyl-[acp] GMP nucleoside triphosphate dCTP an N-terminal 3-aci- (6Z,9Z,12Z,15Z,18Z)-3- an (S)-2- a sophorosyloxyfatty a [lipoyl-carrier a peptide with 3-[(7'-methylsulfanyl) α-D- [+ 4 isozymes] an L-arginyl- a dolichol CTP an acyl-CoA H O sec histidinol N-carbamoyl- LEP1GSC102_RS210305 FGAR UMP a [protein]-L-glutamine serotonin (R)-lipoate tryptamine secologanate 2 a tRNA ser 5,6-dihydrouracil DHAP canavaninosuccinate a 1,2-diacyl- pyrophosphohydrolase: Arg 3-sulfo-L- nitropropanoate oxotetracosapentaenoyl-CoA halocarboxylate acid 6',6''-diacetate protein]-L-lysine an N-terminal heptyl]malate galactopyranose L-aspartate adenylosuccinate lyase: bifunctional [tRNA ] sn-glycerol LEP1GSC102_RS223235 UMP kinase: alanyl-[protein] nitronate monooxygenase: acetyl-CoA C- HAD family hydrolase: transglutaminase: acetylesterase: lipoate--protein ligase: strictosidine synthase: dolichol kinase: acyl-CoA thioesterase: L-alanine argininosuccinate 3-isopropylmalate histidinol guanylate kinase: LEP1GSC102_RS215520 phosphoribosylformylglycinamidine phosphoribosylaminoimidazolecarboxamide arginyl-tRNA-protein transferase: aminopeptidase N: serine--tRNA ligase: pyrimidine reductase: methylglyoxal synthase: galactokinase: 3-phosphate ADP LEP1GSC102_RS220990 guanine and guanosine salvage II LEP1GSC102_RS214700 acyltransferase: LEP1GSC102_RS214620 LEP1GSC102_RS220060 LEP1GSC102_RS225230 LEP1GSC102_RS219240 LEP1GSC102_RS224440 LEP1GSC102_RS225305 LEP1GSC102_RS222175 lyase: argH dehydrogenase: dehydrogenase: LEP1GSC102_RS2000000228645 dUMP synthase: LEP1GSC102_RS215030 formyltransferase/inosine monophosphate LEP1GSC102_RS2000000229490 [unspecified 6 α LEP1GSC102_RS214485 LEP1GSC102_RS217095 LEP1GSC102_RS209450 LEP1GSC102_RS209740 galK AICAR cytidylate kinase: an N-terminal L- LEP1GSC102_RS210020 an (S)-2- a [protein] N -[(5-hydroxy-1H a sophorosyloxyfatty a [lipoyl-carrier protein]- (3 S,21S)- a dolichyl [+ 4 isozymes] leuB hisD CMP phosphorylation LEP1GSC102_RS215025 cyclohydrolase: LEP1GSC102_RS209225 degradation nitrite 3-oxopropanoate a halide anion acetate 6 CDP an L-seryl- fumarate L-canavanine a (2E)-hexadec-2-enoyl-[acp] FAD-dependent LEP1GSC102_RS218740 arginiyl-3-sulfo- a tRNA Arg (4Z,7Z,10Z,13Z,16Z)- hydroxycarboxylate -indol-3-yl)ethyl]-L-glutamine acid O(6'')-acetate N -lipoyl-L-lysine strictosidinate phosphate a peptide ala α ribonucleoside- acetyl-CoA a carboxylate [tRNA sec ] uracil 10-(methylsulfanyl) -D-galactose phosphoribosylformylglycinamidine UDP products] docosapentaenoyl-CoA methylglyoxal (S)-dihydroorotate GDP bifunctional diphosphate reductase, thymidylate synthase: CMP FAICAR guanosine L-alanyl-[protein] -2-oxodecanoate 1-phosphate his a CDP- synthase subunit PurL: phosphoribosylaminoimidazolecarboxamide adenosylcobalamin- LEP1GSC102_RS219705 cytidylate kinase: nucleoside- diacylglycerol LEP1GSC102_RS218940 bifunctional quinone-dependent formyltransferase/inosine monophosphate dependent: dTMP LEP1GSC102_RS218740 diphosphate kinase: CDP-diacylglycerol-- nucleoside- cyclohydrolase: LEP1GSC102_RS209225 CDP phosphoribosylaminoimidazolecarboxamide LEP1GSC102_RS222830 α dihydroorotate ribonucleoside- LEP1GSC102_RS208230 FGAM an (S)-2- D-sedoheptulose -D- 5,6- dCTP N-acetyl-D- α-ribazole a palmitoyl-[acp] glycerol-3-phosphate 3- diphosphate kinase: thymidylate kinase: tmk formyltransferase/inosine monophosphate guanine an L-arginyl- a peptidoglycan aci-nitroethane succinyl-CoA acetoacetate glutathione glycyl-glycine hydrogencarbonate H + FMNH NADP + FMNH NAD + lauroyl-CoA H O pyrazinamide (S)-2- dehydrogenase: diphosphate reductase, FAICAR nucleoside- Arg a protein 2 2 1-phosphate 2 glucopyranose CTP dihydrothymine mannosamine glu phosphatidyltransferase: sphingomyelin metabolism cyclohydrolase: LEP1GSC102_RS209225 UTP [tRNA ] halocarboxylate deoxycytidine aminobutanoate 5'-phosphate LEP1GSC102_RS216860 LEP1GSC102_RS222830 adenosylcobalamin- dADP diphosphate kinase: phosphoribosylformylglycinamidine lysozyme: nitronate monooxygenase: HAD family hydrolase: 3-oxoacid CoA-transferase: gamma- carbonic anhydrase: flavin reductase: flavin reductase: fructose-bisphosphate acyl-CoA thioesterase: 1-phosphate pgsA dTDP arginyl-tRNA-protein transferase: glucose-1-phosphate pyrimidine reductase: triphosphate deaminase: N-acetylneuraminate glutamate- alpha-ribazole PRPP dependent: bifunctional LEP1GSC102_RS222830 cyclo-ligase: LEP1GSC102_RS216015 CTP synthetase: pyrG hypoxanthine LEP1GSC102_RS215750 LEP1GSC102_RS214700 LEP1GSC102_RS214620 LEP1GSC102_RS219285 glutamyltransferase: ggt LEP1GSC102_RS220210 LEP1GSC102_RS225735 LEP1GSC102_RS225735 aldolase: LEP1GSC102_RS218555 amidase: 1-(3-sn- an N-acyl- orotate IMP LEP1GSC102_RS2000000229490 a N-acetylmuramoyl- [unspecified γ cytidylyltransferase: LEP1GSC102_RS209450 LEP1GSC102_RS218985 LEP1GSC102_RS217490 synthase: neuB -cysteine phosphatase: LEP1GSC102_RS208230 phosphoribosylaminoimidazolecarboxamide nucleoside- nucleoside- phosphoribosyltransferase: hpt N-acetyl-D- a (2R)-2- -L-glutamyl- + + LEP1GSC102_RS219700 [+ 4 isozymes] phosphatidyl) sphingosylphosphorylcholine CTP an N-terminal Arg pentapeptide- degradation nitrite acetaldehyde a halide anion acetoacetyl-CoA succinate L-cysteinylglycine H O CO H NADPH FMN H NADH FMN rfbF ligase: gshA cobC GTP formyltransferase/inosine monophosphate diphosphate kinase: diphosphate kinase: AIR CTP a tRNA glucosamine hydroxy fatty acid glycylglycine 2 2 thymine dUTP N-acetyl-β- γ-L-glutamyl-(S)- -sn-glycerol orotate arginyl-[protein] diphosphoundecaprenol products] D-erythrose DHAP laurate CDP-α-D-glucose pyrazine-2- palmitate cyclohydrolase: LEP1GSC102_RS209225 LEP1GSC102_RS222830 LEP1GSC102_RS222830 neuraminate 2-aminobutanoate α-ribazole 3-phosphate sphingomyelin phosphoribosyltransferase: GMP carboxylate dGDP adenine and long-chain fatty phosphodiesterase: pyrE dTTP adenosine salvage VI IMP dATP acid--CoA ligase: sph β β nucleoside- a mature peptidoglycan a 1-O-(alk-1-enyl)-sn-glycero- 13-[O(2')- -D-glucopyranosyl- -D- an (R)-2- a [protein] N-terminal- cis-vaccenyl a DNA containing an N-terminal-L-methionyl- CTP UTP LEP1GSC102_RS209125 sphingosylphosphorylcholine orotidine 5'- (n) + oleoyl-CoA H O an L-1- [+ 3 isozymes] glucopyranosyloxy]docosanoate succinyl-CoA a 3-oxo acid FMN NAD(P)H H tryptamine secologanin an acetyl ester 2 an apurinic/ carbonic acid glu ala prephenate diphosphate kinase: adenosine (meso-DAP containing) 3-phosphoethanolamine halocarboxylate formyl-L-methionine acetate L-cysteinyl-[protein] deoxycytidine nucleoside triphosphate [+ 3 isozymes] phosphatidyl- phosphate lytic transglycosylase O(6'')-acetate acyl-CoA thioesterase: apyrimidinic site type I methionyl LEP1GSC102_RS222830 lysoplasmalogenase: acetylesterase: HAD family hydrolase: 3-oxoacid CoA-transferase: peptide deformylase: flavin reductase: strictosidine synthase: acetylesterase: acetylesterase: endonuclease carbonic anhydrase: triphosphate deaminase: pyrophosphohydrolase: glutamate- prephenate sn-glycerol a sphingosine adenosine kinase: domain-containing protein: LEP1GSC102_RS218555 aminopeptidase: palmitoyl-CoA orotidine-5'- LEP1GSC102_RS211655 LEP1GSC102_RS225230 LEP1GSC102_RS214620 LEP1GSC102_RS219285 LEP1GSC102_RS207880 LEP1GSC102_RS225735 LEP1GSC102_RS224440 LEP1GSC102_RS225230 LEP1GSC102_RS225230 III: nth LEP1GSC102_RS220210 LEP1GSC102_RS217490 LEP1GSC102_RS223235 -cysteine dehydratase: ceramide LEP1GSC102_RS219180 LEP1GSC102_RS211865 sn-glycero-3- a (2R)-2- a 2,3,4-saturated an N-terminal L- 3-α(S)- cis-vaccenyl [+ 4 isozymes] map phosphate dGTP GlcNAc-1,6-anhMurNAc- a mature peptidoglycan a fatty aldehyde acetate sophorosyloxydocosanoate a halide anion succinate formate NAD(P) + FMNH acetate acetate an alcohol a 5'-phospho- a 3'-terminal CO H O ligase: gshA pheA (n) phosphoethanolamine hydroxy fatty acid 3-oxoacyl-CoA methionyl-[protein] 2 strictosidine alcohol 2 2 an N-terminal L- UTP UMP γ-L-glutamyl- decarboxylase: AMP γ oleate [DNA] unsaturated sugar met 3-phenyl-2- L-Ala- -D-Glu-DAP-D-Ala (meso-DAP containing) cysteinyl-[protein] pyrF D-alanine oxopropanoate UMP

hydrogencarbonate (RS)-malate a lipopolysaccharide a fatty acid a nucleotide a sugar 6- phosphate D-glucose phosphate phosphate

predicted ABC RS216780 RS209325 efflux transporter of RS208660 RS218380 RS208555 RS208875 RS214085 RS211770 a lipopolysaccharide

hydrogencarbonate (RS)-malate D-glucose a fatty acid a nucleotide a sugar phosphate phosphate a lipopolysaccharide This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.