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Generated by SRI International Pathway Tools Version 25.0, Authors S Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000244235Cyc: Leptospira interrogans UI 09600 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari a dicarboxylate an amino an amino acid cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate ammonium a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid acid RS211230 RS209125 RS212405 RS217630 RS221825 RS212970 RS217465 cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA ammonium an amino an amino a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA acid acid a dicarboxylate Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Fatty Acid and Lipid Degradation tRNA processing Macromolecule Modification an sn-glycero-3- (R)-4'- sn-glycero-3- 1498 a [protein]- D-glycero-D- Aminoacyl-tRNA Charging fatty acid β-oxidation I + a uracil a [protein]-L- cob(II)yrinate a,c- a purine a cis- sn-glycerol sn-glycerol γ-L-glutamyl-(S)- sn-glycerol NAD NADPH sn-glycerol sn-glycerol π [2Fe-2S] iron-sulfur cluster biosynthesis superpathway of adenosylcobalamin salvage from cobinamide II flavin biosynthesis I (bacteria and plants) 4-aminobenzoate a palmitoyl-[acp] phospho-N-(acyl) phosphopantothenoyl- phospho-N- gly glycerophosphoserine a protein in 16S rRNA N -phospho- roseoflavin manno-heptose methionine diamide biosynthesis I adenosylcobalamin NAD de novo biosynthesis thiamine salvage II a polycistronic ribonucleoside adenosylcobinamide vaccenoyl-[acp] 3-phosphate 3-phosphate 2-aminobutanoate 3-phosphate 3-phosphate 3-phosphate dITP ATP biosynthesis ethanolamine L-cysteine (arachidonoyl) glycerophosphodiester NAD(P)(+) ATP-dependent Clp 16S rRNA (uracil(1498)- L-histidine 5'-phosphate 7-phosphate peptide- (early cobalt insertion) salvage from cobalamin I (from aspartate) tRNA charging tRNA precursor a (3Z)-alk-3- 5'-triphosphate bifunctional glycerol-3- bifunctional glycerol-3- glycerophosphodiester phosphopantothenoylcysteine bifunctional glutamate- bifunctional glycerol-3- bifunctional glycerol-3- bifunctional glycerol-3- phosphohistidine D-glycero- gln bifunctional ethanolamineglycerophosphoryl diester phosphodiesterase: transhydrogenase (Re/ N(3))-methyltransferase: non-canonical purine bifunctional methionine cob(II)inamide 4-amino-2-methyl-5- glutaminyl-tRNA biosynthesis via transamidation enoyl-CoA phosphate dehydrogenase/ phosphate dehydrogenase/ phosphodiesterase: decarboxylase: -cysteine ligase phosphate dehydrogenase/ phosphate dehydrogenase/ phosphate dehydrogenase/ protease proteolytic phosphatase: beta-D- uroporphyrinogen-III L-cysteine desulfurase chorismate adenosylcobinamide phosphodiesterase: LEP1GSC102_RS222700 Si-specific) subunit alpha: LEP1GSC102_RS221375 NTP pyrophosphatase, riboflavin (S)-S-oxide GTP cob(I)alamin asp pyrimidinemethanol glycerol-3-phosphate glycerol-3-phosphate LEP1GSC102_RS222700 LEP1GSC102_RS213420 GshA/glutathione glycerol-3-phosphate glycerol-3-phosphate glycerol-3-phosphate subunit: clpP LEP1GSC102_RS216880 manno- uroporphyrinogen-III aminodeoxychorismate kinase/adenosylcobinamide- LEP1GSC102_RS224120 glycerophosphoryl diester LEP1GSC102_RS217400 16S rRNA (uracil(1498)- RdgB/HAM1 family: rdgB kinase/FAD reductase: cob(I)yrinic acid bifunctional arg acyltransferase: acyltransferase: glycerophosphoryl diester phosphopantothenoylcysteine synthetase GshB: acyltransferase: acyltransferase: acyltransferase: ATP-dependent Clp phosphohistidine heptose-7- C-methyltransferase: cysteine desulfurase: L-aspartate oxidase: synthase, arginine--tRNA ligase: glu phosphate phosphodiesterase: NAD(P) transhydrogenase: N(3))-methyltransferase: nucleoside triphosphate synthetase: msrA a,c-diamide bifunctional 3,4- hydroxymethylpyrimidine long-chain fatty LEP1GSC102_RS216760 LEP1GSC102_RS216760 phosphodiesterase: decarboxylase: glycerophosphodiester LEP1GSC102_RS210935 LEP1GSC102_RS216760 LEP1GSC102_RS216760 LEP1GSC102_RS216760 protease proteolytic subunit: phosphatase phosphate cobA LEP1GSC102_RS222330 LEP1GSC102_RS219620 component I: pabB LEP1GSC102_RS224960 an L-arginyl- a tRNA precursor a tRNA precursor with a 2,3,4-saturated guanylyltransferase: LEP1GSC102_RS224120 LEP1GSC102_RS224145 LEP1GSC102_RS210745 pyrophosphohydrolase: ribF adenosyltransferase: dihydroxy-2-butanone- cob(II)alamin kinase/ 4-amino-4- coenzyme A acid--CoA ligase: a (2E)-2- [+1- 2cis isozymes]-vaccenoyl- [+ 21-palmitoyl- isozymes] LEP1GSC102_RS224120 LEP1GSC102_RS213415 phosphodiesterase: ophthalmate 1-C16:0-α,ω[+- 2 isozymes] [+ 2 isozymes] 1-oleoyl-sn[+ 2 isozymes] LEP1GSC102_RS225575 an N 3 - SixA: sixA roseoflavin adenine D-glycero-βkinase:-D- rfaE1 peptide- precorrin-1 2-iminosuccinate [tRNA Arg ] with a 5' extension a 5' extension and fatty acid LEP1GSC102_RS212635 1-(18- LEP1GSC102_RS223235 cobO phosphomethylpyrimidine deoxychorismate enoyl-CoA a purine adenosyl- sn-glycerol an N- LEP1GSC102_RS222700 sn-glycerol LEP1GSC102_RS224140 1498 a [protein]- dinucleotide methionine an S-sulfanyl-[L- 4-phosphate synthase/ Arg LEP1GSC102_RS212405 acyl-carrier protein sn-glycerol- acyl-carrier protein sn-glycerol 4'-phosphopantetheine sn-glycerol ser dicarboxyl-2- hydroxyoleoyl) -glycerol 3- a peptide methyluracil manno-heptose cob(I)yrinic acid a tRNA and a long 3' trailer a short 3' extension ribonucleoside cobinamide 3-phosphate acylethanolamine anandamide 3-phosphate + L-histidine dIMP (S)-S-oxide uroporphyrinogen-III cysteine desulfurase] ATP:cob(I)alamin GTP cyclohydrolase II: quinolinate synthase: kinase: thiD [+ 3 isozymes] 3-phosphate 3-phosphate 3-phosphate lysophosphatidate NADP NADH -sn-glycrol phosphate in 16S rRNA 1,7-bisphosphate a,c-diamide acyl-CoA dehydrogenase: a 2,3,4- 5'-diphosphate phosphate reductase: C-methyltransferase: adenosyltransferase: LEP1GSC102_RS218350 LEP1GSC102_RS208905 gln an L-glutamyl- ribonuclease 3-phosphate adenosyltransferase: HMP-P LEP1GSC102_RS223025 saturated (3R)-3- msrA cobA LEP1GSC102_RS207985 Gln P protein 2,5-diamino-6-(5-phospho-D- cobO [tRNA ] [+ 10 isozymes] a 2,3,4- hydroxyacyl-CoA a protein-L- [corrinoid ribosylamino)pyrimidin-4(3H)-one quinolinate bifunctional 5-(2-hydroxyethyl) 4-aminobenzoate imidazole glycerol ribonuclease D: ribonuclease D: component: a 2,3,4-saturated methionine- precorrin-2 an S-sulfanyl-[cysteine cob(II)alamin- Asp-tRNA(Asn) saturated (3S)-3- adenosyltranferase]- bifunctional hydroxymethylpyrimidine -4-methylthiazole cys phosphate synthase cyclase: LEP1GSC102_RS220595 LEP1GSC102_RS223115 rnpA fatty acyl CoA (S)-S-oxide desulfurase]-[disordered- [corrinoid nicotinate- cysteine--tRNA ligase: /Glu-tRNA(Gln) hydroxyacyl-CoA bifunctional precorrin- cob(II)inamide diaminohydroxyphosphoribosylaminopyrimidine kinase/ LEP1GSC102_RS221550 ribonuclease D: ribonuclease D: form scaffold adenosyltranferase] nucleotide hydroxyethylthiazole kinase: LEP1GSC102_RS225225 an L-cysteinyl- amidotransferase Amino Acid Degradation 2 dehydrogenase/ deaminase/5-amino-6-(5-phosphoribosylamino) phosphomethylpyrimidine gatA LEP1GSC102_RS223115 LEP1GSC102_RS220595 a tRNA precursor with protein] complex pyridoxal 5'-phosphate biosynthesis I diphosphorylase LEP1GSC102_RS220485 Cys subunit GatA: gatA undecaprenyl- 1-stearoyl- sn-glycero-3- adenine 1518 / 3-octaprenyl-4- a [DNA]-3'- a 5'-phospho- an [RNA]-3'- a [protein]-α- a [protein]- [tRNA ] [+ 7 isozymes] a short 3' extension sn-glycerol + sn-glycerol τ sirohydrochlorin uracil reductase: LEP1GSC102_RS218340 kinase: thiD Cys a 5-phosphooxy- oleate glycerophosphoglycerol NAD acetyl-CoA (carboxylating) 4-methyl-5-(2- a tRNA diphospho-N- a myristoyl-[acp] a stearoyl-[acp] sn-glycerol phosphoethanolamine adenine 1519 in 16S rRNA hydroxybenzoate hydroxyl [DNA] ribonucleoside- L-glutamate N -phospho- phosphoenol ferrochelatase: [corrinoid L-leucine degradation I ATP cob(II)inamide 3-phosphate 3-phosphate XTP dGDP GMP IMP 5-amino-6-(5-phospho- D-erythrose cob(I)alamin- : nadC phosphooxyethyl) ammonium L-glutamyl- a 2,3,4-saturated a 2,3,4-saturated acetylmuramoyl- UDP-N-acetyl- bifunctional glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- long-chain fatty glycerophosphodiester 16S rRNA (adenine(1518)- glycerophosphoryl diester UbiD family decarboxylase: DNA acetyl-CoA carboxylase bifunctional glycerol-3- 2',3'- protein-glutamate O- L-histidine pyruvate LEP1GSC102_RS224430 adenosyltranferase]- HMP-PP Gln phosphohistidine non-canonical purine pyruvate D-ribosylamino)uracil 4-phosphate [corrinoid thiazole [tRNA ] ribonuclease D: fatty acyl CoA 3-oxoacyl-CoA L-alanyl-γ-D- α-D-glucosamine ATP:cob(I)alamin phosphate dehydrogenase/ phosphate acyltransferase: acid--CoA ligase: phosphodiesterase: N(6)/adenine(1519)-N(6))- phosphodiesterase: LEP1GSC102_RS209045 ligase biotin carboxyl: phosphate dehydrogenase/ cyclophosphate methyltransferase CheR: a [cysteine desulfurase]- cob(I)inamide RNA 2',3'-cyclic phosphatase: NTP pyrophosphatase, kinase: pyk 5'-nucleotidase 5'-nucleotidase bifunctional adenosyltranferase] NaMN
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