C: Compulsory Subject, E: Elective Subject

Forth Semester (Spring 2016) Code Subject Credit C/E Description Practices on inorganic chemistry, analytical chemistry, solid state chemistry, and geochemistry are conducted by lecturers. Schedule of this lecture (each of lectures and topics) is roughly as follows. Change will be announced on the billboard in Department of Chemistry. 1. Evaluation of solid state physical property Practice in Inorganic and Analytical 8. Complex chemistry of lanthanoid 2. Principle of solid state device 0530049 Chemistry 1 E 9. Catalytic reaction using transition metal complex 3. Evaluation and development of functional oxide film 10. Basis and recent topics of electrochemistry 4. Electronic state and physical property of functional oxide film 11. Material science opened by organic radical 5. Analysis method based on antigen-antibody reaction 12. Supramolecule chemistry using nucleic acid 6. Invention and principle of DNA sequencing method 13. Catalytic reaction featuring enzyme as its motif 7. Basis and application of chemical probe In the first half of this lecture, the following topics are discussed: reactive species other than anions and cations (which have already been addressed), namely, radical cations and radical anions, free radicals and radical chain reactions, carbenes and carbene complexes, and the structures and reactions of organometallic complexes. In the second half of this lecture, pericyclic reactions based on Woodward—Hoffmann rules are explained. Frontier orbital theory and the Dewar—Zimmerman transition state aromaticity method, used to estimate whether a pericyclic reaction is symmetry forbidden or symmetry allowed, are introduced. The course contents learned in Organic Chemistry I—III are prerequisite.

The schedule of this lecture is as follows:

First half 1. Neutral molecules: Molecular orbitals, one-electron oxidation, and one-electron reduction Special Topics in Organic Chemistry II 0530066 2 E 2. Radical cations and radical anions: Structure and reactivity 3. Free radicals: Structure, stability, generation method, and radical chain reactions and their applications in syntheses 4. Carbenes: Structures and metal complexes 5. Organometallic reactive species.

Second half 1. Pericyclic reactions 2. Electrocyclic reactions 3. Cycloaddition reactions 4. Sigmatropic reactions 5. Cheletropic reactions. First half: In this lecture, recent topics of organic reaction chemistry, organic synthesis chemistry, and organometallic chemistry are explained roughly. Schedule of this lecture is as follows. 1. Recent topics of organic reaction chemistry 2. Recent topics of organic synthesis chemistry 3. Recent topics of organometallic chemistry Second half: Principle and practice of isolation process to reach a target molecule from an extract of biological material which is an ultimate mixture of Special Topics in Organic Chemistry I 0530050 2 E organic compounds, are to be understood conceptually. Next, the principles of following spectroscopic analysis methods will be introduced for understanding of how to obtain chemical structure of organic compounds, and selection of adequate method(s) to obtain a certain structural information 1. What is resonance?, kinds of electromagnetic waves and levels to be excited 2. Ultraviolet and visible absorption, fluorescence, optical rotation and circular dichroism 3. Infrared absorption, Fourier transformation, and accumulation 4. Hydrogen and carbon nuclear magnetic resonances 5. Mass spectrometry Biomolecules, which are components of a living system, have unique functions such as molecular recognition and catalytic reactions. These functions are expressed by the biomolecules or a huge molecular complex. Understanding biomolecules deeply assists invention of a functional synthetic molecule and development of analysis methods for clarifying molecular mechanisms. In this lecture, chemistry related with living phenomena is discussed from the viewpoints of structure, function, mutual recognition of biomolecules, and bio-inspired artificial molecules. General description of this lecture Biomolecular Chemistry ・Structure and function of nucleic acids and proteins ・ 0530071 2 E Roles of bio-related metal ions ・Signaling molecules and analytical methods ・Artificial biopolymers: design and functionalization ・Specific reactions and applications of proteins ・Molecular evolution and its application ・Reception of external information and signal transduction through cell membranes ・Chemical signal transduction among cells ・Interactions and thermodynamics among biomolecules and among biomolecules and small molecules In this lecture, in order to deepen understanding of lectures in the second and third semesters, lecturers in organic chemistry give practices on organic reaction chemistry, organic synthesis chemistry, physical organic chemistry, and structural determination of organic compounds. Contents of this lecture are as follows, and general questions will be also given. 1. Organometallic chemistry (structure of organometallic complex and its application to synthetic reaction), physical organic chemistry (molecular orbital Practice in Organic Chemistry 0530052 1 E method, cyclic reaction, isotope effect) 2. Structural determination of organic compounds (analysis of NMR, IR, MS, and UV/vis spectra) 3. Organic synthesis chemistry (synthesis and reaction of alkene, alkyne, and carbonyl compounds) 4. Organic reaction chemistry (reactivity, reaction mechanism, and chemical kinetics of aliphatic compounds and aromatic compounds) 5. Bioorganic chemistry (synthesis and reaction of amino acid, nucleic acid, and so on) Special Topics in Inorganic and Recent progress and its basic theory of inorganic chemistry, analytical chemistry, solid state chemistry, and geochemistry are introduced by 11 lecturers in 0530048 Analytical Chemistry 2 E omnibus form, and every lecture treats different theme. Special Topics in Physical Chemistry II 0530065 2 E Lectures will be given on the research subjects in frontier research areas in physical chemistry by a total of 11 professors in an omnibus form.

Practice in Physical Chemistry By solving standard exercise problems, students deepen their understanding of a variety of subjects in structural chemistry, molecular spectroscopy, chemical 0530047 1 E reaction dynamics, solid state chemistry, and surface chemistry.

Special Laboratory Work in Chemistry Laboratory work for graduation thesis are conducted in one of the laboratories of physical chemistry, organic chemistry, and inorganic and analytical 0530014 7.5 C chemistry.