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Arvola Joona Opinnayte.Pdf (3.130Mb)
Hydrolysoituvien tanniinien rakenteen vaikutus niiden makromolekyyliaffiniteettiin Joona Arvola Pro gradu -tutkielma Luonnonyhdistekemian tutkimusryhmä Kemian laitos Turun yliopisto Joulukuu 2019 Turun yliopiston laatujärjestelmän mukaisesti tämän julkaisun alkuperäisyys on tarkastettu Turnitin OriginalityCheck -järjestelmällä. _________________________________________________________________________ TURUN YLIOPISTO Kemian laitos ARVOLA, JOONA: Hydrolysoituvien tanniinien rakenteen vaikutus niiden makromolekyyliaffiniteettiin Pro gradu -tutkielma, 80 s., liitteet 10 s. Kemia Joulukuu 2019 Hydrolysoituvat tanniinit ovat rakeenteiltaan hyvin monipuolinen joukko luonnonyhdisteitä, joilla on havaittu olevan kyky sitoutua makromolekyyleihin. Eniten on tutkittu niiden kykyä sitoutua proteiineihin, mutta myös mm. polysakkaridien kanssa on tehty tutkimuksia. Kun hydrolysoituvat tanniinit sitoutuvat makromolekyyleihin, muodostavat ne liukoisia ja liukenemattomia tanniini–makromolekyyli -komplekseja, joita voidaan tutkia monilla erilaisilla menetelmillä. Eniten on tutkittu tanniini–proteiini -komplekseja, jotka ovat muodostuneet heikkojen vuorovaikutusten johdosta. Heikkoja vuorovaikutuksia ovat hydrofobiset voimat ja vetysidokset, jotka muodostuvat hydrolysoituvien tanniinien fenolisten ryhmien ja proteiinien hydrofobisten ja hydrofiilisten kohtien välille. Hydrolysoituvien tanniinien proteiiniaffiniteettiin vaikuttavat eniten fenolisten ryhmien lukumäärä niiden rakenteessa, mutta erilaiset fenoliset ryhmät vaikuttavat kuitenkin eri tavoin yhdisteiden -
Chemical Composition, Antioxidant Activity, and Sensory Characterization of Commercial Pomegranate Juices
antioxidants Article Chemical Composition, Antioxidant Activity, and Sensory Characterization of Commercial Pomegranate Juices Sonia Esposto, Gianluca Veneziani, Agnese Taticchi, Stefania Urbani, Roberto Selvaggini, Beatrice Sordini * , Luigi Daidone, Giacomo Gironi and Maurizio Servili Department of Agricultural, Food and Environmental Sciences, University of Perugia, Via San Costanzo s.n.c., 06126 Perugia, Italy; [email protected] (S.E.); [email protected] (G.V.); [email protected] (A.T.); [email protected] (S.U.); [email protected] (R.S.); [email protected] (L.D.); [email protected] (G.G.); [email protected] (M.S.) * Correspondence: [email protected]; Tel.: +39-075-5857951; Fax: +39-075-5857916 Abstract: We undertook a qualitative and quantitative assessment of the bioactive compounds, volatile substances, sensory profile, and antioxidant activity of eight different commercial pomegranate juices (PJs) differing by cultivation area, processing (from concentrate (CPJ) or not (NCPJ)), and mi- crobial stabilization. Punicalins were the main ellagitannins, whereas the predominant anthocyanin was cyanidin 3,5-diglucoside, followed by cyanidin 3-glucoside. Total phenols, tannins, hydrolyzable tannins, and anthocyanins in the investigated juices ranged from 1379.9 to 3748.8 mg gallic acid equivalent (GAE)/L, 394.8 to 895.2 mg GAE/L, 150.8 to 2374.2 mg ellagic acid/L, and 0 to 281 mg • cyanidin 3-glucoside/L, respectively. Antioxidant activity, determined by DPPH , FRAP, and ABTS, was positively correlated with the total phenolic compounds and hydrolyzable tannins. Alcohols, Citation: Esposto, S.; Veneziani, G.; acids, and furans were the volatile groups that best described the differences between juices. -
Punicalin Alleviates OGD/R-Triggered Cell Injury Via TGF-Β-Mediated Oxidative Stress and Cell Cycle in Neuroblastoma Cells SH-SY5Y
Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2021, Article ID 6671282, 11 pages https://doi.org/10.1155/2021/6671282 Research Article Punicalin Alleviates OGD/R-Triggered Cell Injury via TGF-β-Mediated Oxidative Stress and Cell Cycle in Neuroblastoma Cells SH-SY5Y Tiansong Yang,1 Qingyong Wang,2 Yuanyuan Qu,2 Yan Liu,1 Chuwen Feng,1 Yulin Wang,2 Weibo Sun,3 Zhongren Sun ,2 and Yulan Zhu4 1First affiliated hospital, Heilongjiang University of Chinese Medicine, Harbin, China 2Heilongjiang University of Chinese Medicine, Harbin, China 3Harbin Medical University, Harbin, China 4Department of Neurology, %e Second Affiliated Hospital of Harbin Medical University, Harbin, China Correspondence should be addressed to Zhongren Sun; [email protected] Received 21 October 2020; Revised 21 October 2020; Accepted 7 January 2021; Published 12 February 2021 Academic Editor: Muhammad Farrukh Nisar Copyright © 2021 Tiansong Yang et al. /is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. /e research aimed to identify the active component from Punica granatum L. to alleviate ischemia/reperfusion injury and clarify the underlying mechanism of the active component alleviating ischemia/reperfusion injury. Materials and Methods. /e SH-SY5Y cell model of oxygen-glucose deprivation/reoxygenation (OGD/R) was established to simulate the ischemia/ reperfusion injury. According to the strategy of bioassay-guided isolation, the active component of punicalin from Punica granatum L. was identified. Flow cytometry and Western blotting were employed to evaluate the effects of OGD/R and/or punicalin on cell cycle arrest. -
Punica Granatum L
Research Article Studies on antioxidant activity of red, white, and black pomegranate (Punica granatum L.) peel extract using DPPH radical scavenging method Uswatun Chasanah[1]* 1 Department of Pharmacy, Faculty of Health Science, University of Muhammadiyah Malangg, Malang, East Java, Indonesia * Corresponding Author’s Email: [email protected] ARTICLE INFO ABSTRACT Article History Pomegranate (Punica granatum L.) has high antioxidant activity. In Received September 1, 2020 Indonesia, there are red pomegranate, white pomegranate, and black Revised January 7, 2021 pomegranate. The purpose of this study was to determine the antioxidant Accepted January 14, 2021 activity of red pomegranate peel extract, white pomegranate peel extract, Published February 1, 2021 and black pomegranate peel extract. The extracts prepared by ultrasonic maceration in 96% ethanol, then evaporated until thick extract was Keywords obtained and its antioxidant activity was determined using the DPPH Antioxidant radical scavenging method. This study showed that all pomegranate peel Black pomegranate extract varieties have potent antioxidant activity and the black Red pomegranate pomegranate peel extract has the highest antioxidant power. White pomegranate Peel extract DPPH Doi 10.22219/farmasains.v5i2.13472 1. INTRODUCTION Pomegranate (Punica granatum L.) belongs to the Puricaceae family, a plant originating from the Middle East (Rana, Narzary & Ranade, 2010). All parts of the pomegranate, such as fruit (fruit juice, fruit seeds, peel fruit), leaves, flowers, roots, and bark, have therapeutic effects such as neuroprotective, antioxidant, repair vascular damage, and anti-inflammatory. The clinical application of this plant used in cancers, atherosclerosis, hyperlipidemia, carotid artery stenosis, myocardial perfusion, periodontal disease, bacterial infections, ultraviolet radiation, erectile dysfunction, male infertility, neonatal hypoxic-ischemic brain injury, Alzheimer's disease, and obesity (Jurenka, 2008; Mackler, Heber & Cooper, 2013). -
A Review on Antihyperglycemic and Antihepatoprotective Activity of Eco-Friendly Punica Granatum Peel Waste
Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 656172, 10 pages http://dx.doi.org/10.1155/2013/656172 Review Article A Review on Antihyperglycemic and Antihepatoprotective Activity of Eco-Friendly Punica granatum Peel Waste Sushil Kumar Middha,1 Talambedu Usha,2 and Veena Pande1 1 Department of Biotechnology, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand 263136, India 2 Department of Biotechnology & Biochemistry, Maharani Lakshmi Ammanni College for Women, Bangalore 560012, India Correspondence should be addressed to Veena Pande; veena [email protected] Received 28 December 2012; Revised 25 March 2013; Accepted 25 April 2013 Academic Editor: Edwin L. Cooper Copyright © 2013 Sushil Kumar Middha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Over the past decade, pomegranate (Punica granatum) is entitled as a wonder fruit because of its voluminous pharmacological properties. In 1830, P. g ranatum fruit was first recognized in United States Pharmacopeia; the Philadelphia edition introduced the rind of the fruit, the New York edition the bark of the root and further 1890 edition the stem bark was introduced. There are significant efforts and progress made in establishing thepharmacological mechanisms of peel (pericarp or rind) and the individual constituents responsible for them. This review provides an insight on the phytochemical components that contribute too antihyperglycemic, hepatoprotective, antihyperlipidemic effect, and numerous other effects of wonderful, economic, and eco- friendly pomegranate peel extract (PP). 1. Introduction containing sacs packed with a fleshy, juicy, red or whitish pulp. -
Evaluation of Punicalagin Niosomes for Skin Aging
Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 24 March 2021 Evaluation of Punicalagin Niosomes for Skin Aging Ebtesam A. Mohamada, Aya A. Alyb, Aya A. Khalafb, Mona I. Ahmedb, Reham M. Kamelb, Sherouk M. Abdelnabyb, Yasmine H. Abdelzaherb, Marize G. Sedrak b, Shaker A. Mousac a Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt; b Biotechnology / Biomolecular Chemistry Program, Faculty of Science, Cairo University, Cairo, Egypt; c The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA *Corresponding Author: Shaker A. Mousa, PhD, MBA, FACC, FACB Professor of Pharmacology and Chairman of The Pharmaceutical Research Institute Albany College of Pharmacy and Health Sciences Rensselaer, NY 12144, USA Email: [email protected] Tel: +1-518-694-7397 & Fax: +1-518-694-7567 Abstract Skin aging is one of the most common problems facing humanity. It occurs because of altering the balance between free radicals and antioxidants and increasing the amount of the reactive oxygen species (ROS) in skin cells, which leads to oxidative stress especially when exposed to UV radiation. Antioxidants can neutralize the harmful effects of ROS, and secondary plant metabolites can help protect against UV radiation. In this study, punicalagin was extracted from pomegranate and concentrations of total polyphenolics and flavonoids were determined and antioxidant activities measured. Punicalagin was loaded onto niosomes and its morphology and release were studied. An in vitro study was performed on human fibroblast cell line HFB4 cells with aging induced by H2O2 and UV radiation. Cell cycle arrest was studied and different genes (MMP3, Col1A1, Timp3, and TERT) involved in the skin aging process were selected to measure punicalagin's effect. -
Pomegranate: Nutraceutical with Promising Benefits on Human Health
Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 8 September 2020 Review Pomegranate: nutraceutical with promising benefits on human health Anna Caruso 1, +, Alexia Barbarossa 2,+, Antonio Tassone 1 , Jessica Ceramella 1, Alessia Carocci 2,*, Alessia Catalano 2,* Giovanna Basile 1, Alessia Fazio 1, Domenico Iacopetta 1, Carlo Franchini 2 and Maria Stefania Sinicropi 1 1 Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Arcavacata di Rende (Italy); anna.caruso@unical .it (Ann.C.), [email protected] (A.T.), [email protected] (J.C.), [email protected] (G.B.), [email protected] (A.F.), [email protected] (D.I.), [email protected] (M.S.S.) 2 Department of Pharmacy‐Drug Sciences, University of Bari “Aldo Moro”, 70126, Bari (Italy); [email protected] (A.B.), [email protected] (Al.C.), [email protected] (A.C.), [email protected] (C.F.) + These authors equally contributed to this work. * Correspondence: [email protected] Abstract: The pomegranate, an ancient plant native to Central Asia, cultivated in different geographical areas including the Mediterranean basin and California, consists of flowers, roots, fruits and leaves. Presently, it is utilized not only for the exterior appearance of its fruit but above all, for the nutritional and health characteristics of the various parts composing this last one (carpellary membranes, arils, seeds and bark). The fruit, the pomegranate, is rich in numerous chemical compounds (flavonoids, ellagitannins, proanthocyanidins, mineral salts, vitamins, lipids, organic acids) of high biological and nutraceutical value that make it the object of study for many research groups, particularly in the pharmaceutical sector. -
278-281 Research Article Computational Studies on The
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2014, 6(9):278-281 ISSN : 0975-7384 Research Article CODEN(USA) : JCPRC5 Computational studies on the antiobesity effect of polyphenols from pomegranate leaf Sudeep H. V.* and Shyam Prasad K. Department of Biomedicinal Research, Vidya Herbs Pvt. Ltd, #101, Jigani II phase, Bangalore, Karnataka, India _____________________________________________________________________________________________ ABSTRACT Different polyphenols present in Pomegranate leaves were docked into validated drug targets of obesity which include enzymes pancreatic lipase and fat mass and obesity associated protein (FTO). The in silico calculations predicted that lowest energy docked poses of phenolic compounds can interact with catalysis-dependent residues, thus making them possible catalytic inhibitors and of course physiologically active. Compounds that possess a number of hydrogen-bond-accepting and/or -donating groups like phenolics and quinones show extensive interactions with the targets. Based on the ligand-protein interaction we can conclude that phenolic principles like Punicalagin, corilagin, punicalin and apigenin thus offer profound promise as anti-obesity drugs. This study has immediate applications in development of non-toxic drugs/nutraceuticals that may safeguard human populations against severe complications associated with obesity. Key words: Docking, Obesity, Pomegranate, Polyphenols _____________________________________________________________________________________________ INTRODUCTION Weight gain and obesity are major risk factors for the health complications ranging from insulin resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty liver disease[1]. Physiologically, obesity is a disarray of energy balance and primarily considered as a disorder of lipid metabolism[2]. The condition is associated with a growing number of enzymes involved in lipid metabolic pathways. -
Punicalagin Content and Antifungal Activity of Different
horticulturae Article Punicalagin Content and Antifungal Activity of Different Pomegranate (Punica ganatum L.) Genotypes Domenico Rongai 1,*, Patrizio Pulcini 1, Giovanni Di Lernia 1, Paolo Nota 1, Pjerin Preka 2 and Filomena Milano 1 1 CREA-DC Research Centre for Plant Protection and Certification, via C.G Bertero, 22, 00156 Rome, Italy 2 CREA-OFA Research Centre for Olive, Citrus and Tree fruit, Via di Fioranello, 52, 00134 Rome, Italy * Correspondence: [email protected] Received: 16 May 2019; Accepted: 1 July 2019; Published: 16 July 2019 Abstract: This study investigated the antifungal activity of a number of pomegranate genotypes. Since the main compound of pomegranate extract is punicalagin, an important substance involved in antifungal and antimicrobial activity, we analyzed the contents of punicalagin (α and β) in 21 different pomegranate genotypes. Ellagic acid content, total phenolic content, acidity and pH were also determined. This work allowed us to determine which genotypes of pomegranate can be used to obtain extracts with the highest content of punicalagin, with the goal of developing a green alternative to synthetic pesticides. To improve the extraction system from pomegranate peel fruits, several different solvents were tested. All the pomegranate genotypes tested showed antifungal activity; some genotypes were able to almost completely inhibit the fungus, while others had very low inhibitory activity. Research results also showed that the use of water as a solvent for extraction is very effective, especially when it is combined with ethanol. This is very important for the practical use of the extracts since water is economical and environmentally friendly. The research showed that among the genotypes there is also great variability regarding the chemical parameters. -
Journal of Drug Delivery and Therapeutics Punica Granatum L
Kumari et al Journal of Drug Delivery & Therapeutics. 2021; 11(3):113-121 Available online on 15.05.2021 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-21, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use(CC By-NC), provided the original work is properly cited Open Access Full Text Article Review Article Punica granatum L. (Dadim), Therapeutic Importance of World’s Most Ancient Fruit Plant Kumari Isha, Kaurav Hemlata, Chaudhary Gitika* Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd. Zirakpur, 140603, Punjab, India Article Info: Abstract ___________________________________________ ______________________________________________________________________________________________________ Article History: The custom of using plants for the therapeutic and dietary practices is as old as origin of Received 23 March 2021; humanity on the earth. One of the most ancient fruit plant is Punica granatum L., Review Completed 20 April 2021 pomegranate belongs to Lythraceae family. The plant has a very rich ethnic history of its Accepted 26 April 2021; utilization around the world. The plant was used to symbolize prosperity, life, happiness, Available online 15 May 2021 fertility etc. Apart from the ethnic beliefs associated with the plant, it is a well-considered ______________________________________________________________ plant based remedy used in treatment of many diseases in traditional system like Ayurveda Cite this article as: and folk system of medicine. In Ayurveda it is esteemed as a Rasayana. It is used in many Ayurvedic polyherbal formulations which are used against many diseases. The plant Kumari I, Kaurav H, Chaudhary G, Punica granatum L. (Dadim), Therapeutic Importance of World’s Most consists of numerous phytochemical constituents in it such as polysaccharides, minerals, Ancient Fruit Plant, Journal of Drug Delivery and polyphenols, tannins, saponins, quinones, alkaloids, glycosides, coumarins, terpenoids, Therapeutics. -
Production and Extraction by Solid-State Fermentation. a Review
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Universidade do Minho: RepositoriUM Biotechnology Advances 29 (2011) 365–373 Contents lists available at ScienceDirect Biotechnology Advances journal homepage: www.elsevier.com/locate/biotechadv Research review paper Bioactive phenolic compounds: Production and extraction by solid-state fermentation. A review Silvia Martins a, Solange I. Mussatto a,⁎, Guillermo Martínez-Avila b, Julio Montañez-Saenz c, Cristóbal N. Aguilar b, Jose A. Teixeira a a Institute for Biotechnology and Bioengineering (IBB), Centre of Biological Engineering, University of Minho, Campus Gualtar, 4710–057, Braga, Portugal b Food Research Department, School of Chemistry, Autonomous University of Coahuila, Blvd. Venustiano Carranza S/N Col. República Oriente, 25280, Saltillo, Coahuila, Mexico c Department of Chemical Engineering, School of Chemistry, Autonomous University of Coahuila, Blvd. Venustiano Carranza S/N Col. República Oriente, 25280, Saltillo, Coahuila, Mexico article info abstract Article history: Interest in the development of bioprocesses for the production or extraction of bioactive compounds from Received 27 July 2010 natural sources has increased in recent years due to the potential applications of these compounds in food, Received in revised form 20 January 2011 chemical, and pharmaceutical industries. In this context, solid-state fermentation (SSF) has received great Accepted 21 January 2011 attention because this bioprocess has potential to successfully convert inexpensive agro-industrial residues, Available online 1 February 2011 as well as plants, in a great variety of valuable compounds, including bioactive phenolic compounds. The aim Keywords: of this review, after presenting general aspects about bioactive compounds and SSF systems, is to focus on the Solid-state fermentation production and extraction of bioactive phenolic compounds from natural sources by SSF. -
Le Bioraffinage De Myrrhis Odorata, Tussilago Farfara Et Calamintha Grandiflora Pour La Production D'aromes Et D'antioxydants
En vue de l'obtention du DOCTORAT DE L'UNIVERSITÉ DE TOULOUSE Délivré par : Institut National Polytechnique de Toulouse (INP Toulouse) Discipline ou spécialité : Sciences des Agroressources Présentée et soutenue par : Mme DIANA DOBRAVALSKYTE le lundi 25 novembre 2013 Titre : LE BIORAFFINAGE DE MYRRHIS ODORATA, TUSSILAGO FARFARA ET CALAMINTHA GRANDIFLORA POUR LA PRODUCTION D'AROMES ET D'ANTIOXYDANTS. Ecole doctorale : Sciences de la Matière (SM) Unité de recherche : Laboratoire de Chimie Agro-Industrielle (L.C.A.) Directeur(s) de Thèse : M. THIERRY TALOU M. RIMANTAS VENSKUTONIS Rapporteurs : Mme CHANTAL MENUT, UNIVERSITE MONTPELLIER 2 Mme JOLANTA LIESIENE, UNIVERSITE DE TECHNOLOGIE DE KAUNAS Membre(s) du jury : 1 M. ZIGMUNTAS BERESNEVICIUS, UNIVERSITE DE TECHNOLOGIE DE KAUNAS, Président 2 M. ALGIRDAS ZEMAITAITIS, UNIVERSITE DE TECHNOLOGIE DE KAUNAS, Membre 2 Mme GRAZINA JUODEIKIENÉ, UNIVERSITE DE TECHNOLOGIE DE KAUNAS, Membre 2 Mme ISABELLE FOURASTE, UNIVERSITE TOULOUSE 3, Membre 2 Mme RUTA GALABURDA, LATVIA UNIVERSITY OF AGRICULTURE JELGAVA, Membre 2 M. RIMANTAS VENSKUTONIS, UNIVERSITE DE TECHNOLOGIE DE KAUNAS, Membre REMERCIEMENTS Tout d’abord j’adresse mes remerciements aux différents organismes qui ont mis les moyens financiers pour l’aboutissement de cette thèse: aux gouvernements de la Lituanie et la France, ainsi que Campus France avec la bourse d'Excellence Égide Eiffel. Je remercie les Professeurs Dr. Jolanta LIESIENĖ et Dr. Chantal MENUT pour m'avoir fait l'honneur d'être les rapporteurs de ma thèse. Je remercie également les professeurs Dr. Algirdas ŽEMAITAITIS, Dr. Gražina JUODEIKIENĖ, Dr. Zigmuntas Jonas BERESNEVIČIUS, Dr. Isabelle FOURASTÉ, Dr. Audrius Sigitas MARUŠKA et Dr. Ruta GALOBURDA d’avoir participés en tant qu’examinateurs.