Example Write up #1: a Patient with Diarrhea
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Peptic Ulcer Disease
Peptic Ulcer Disease orking with you as a partner in health care, your gastroenterologist Wat GI Associates will determine the best diagnostic and treatment measures for your unique needs. Albert F. Chiemprabha, M.D. Pierce D. Dotherow, M.D. Reed B. Hogan, M.D. James H. Johnston, III, M.D. Ronald P. Kotfila, M.D. Billy W. Long, M.D. Paul B. Milner, M.D. Michelle A. Petro, M.D. Vonda Reeves-Darby, M.D. Matt Runnels, M.D. James Q. Sones, II, M.D. April Ulmer, M.D., Pediatric GI James A. Underwood, Jr., M.D. Chad Wigington, D.O. Mark E. Wilson, M.D. Cindy Haden Wright, M.D. Keith Brown, M.D., Pathologist Samuel Hensley, M.D., Pathologist Jackson Madison Vicksburg 1421 N. State Street, Ste 203 104 Highland Way 1815 Mission 66 Jackson, MS 39202 Madison, MS 39110 Vicksburg, MS 39180 Telephone 601/355-1234 • Fax 601/352-4882 • 800/880-1231 www.msgastrodocs.com ©2010 GI Associates & Endoscopy Center. All rights reserved. A discovery that Table of contents brought relief to millions of ulcer What Is Peptic Ulcer Disease............... 2 patients...... Three Major Types Of Peptic Ulcer Disease .. 6 The bacterium now implicated as a cause of some ulcers How Are Ulcers Treated................... 9 was not noticed in the stomach until 1981. Before that, it was thought that bacteria couldn’t survive in the stomach because Questions & Answers About Peptic Ulcers .. 11 of the presence of acid. Australian pathologists, Drs. Warren and Marshall found differently when they noticed bacteria Ulcers Can Be Stubborn................... 13 while microscopically inspecting biopsies from stomach tissue. -
Antibiotic-Associated Diarrhea: Candidate Organisms Other Than Clostridium Difficile
The Korean Journal of Internal Medicine : 23:9-15, 2008 Antibiotic-Associated Diarrhea: Candidate Organisms other than Clostridium Difficile Hyun Joo Song, M.D.1, Ki-Nam Shim, M.D.1, Sung-Ae Jung, M.D.1, Hee Jung Choi, M.D.1, Mi Ae Lee, M.D.2, Kum Hei Ryu, M.D.1, Seong-Eun Kim, M.D.1 and Kwon Yoo, M.D.1 Department of Internal Medicine1 and Laboratory Medicine2, Ewha Medical Research Institute, College of Medicine, Ewha Womans University, Seoul, Korea Background/Aims : The direct toxic effects of antibiotics on the intestine can alter digestive functions and cause pathogenic bacterial overgrowth leading to antibiotic-associated diarrhea (AAD). Clostridium difficile (C. difficile) is widely known to be responsible for 10~20% of AAD cases. However, Klebsiella oxytoca, Clostridium perfringens, Staphylococcus aureus, and Candida species might also contribute to AAD. Methods : We prospectively analyzed the organisms in stool and colon tissue cultures with a C. difficile toxin A assay in patients with AAD between May and December 2005. In addition, we performed the C. difficile toxin A assays using an enzyme-linked fluorescent assay technique. Patients were enrolled who had diarrhea with more than three stools per day for at least 2 days after the initiation of antibiotic treatment for up to 6~8 weeks after antibiotic discontinuation. Results : Among 38 patients (mean age 59±18 years, M:F=18:20), the organism isolation rates were 28.9% (11/38) for stool culture, 18.4% (7/38) for colon tissue cultures and 13.2% (5/38) for the C. -
Does Your Patient Have Bile Acid Malabsorption?
NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #198 NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #198 Carol Rees Parrish, MS, RDN, Series Editor Does Your Patient Have Bile Acid Malabsorption? John K. DiBaise Bile acid malabsorption is a common but underrecognized cause of chronic watery diarrhea, resulting in an incorrect diagnosis in many patients and interfering and delaying proper treatment. In this review, the synthesis, enterohepatic circulation, and function of bile acids are briefly reviewed followed by a discussion of bile acid malabsorption. Diagnostic and treatment options are also provided. INTRODUCTION n 1967, diarrhea caused by bile acids was We will first describe bile acid synthesis and first recognized and described as cholerhetic enterohepatic circulation, followed by a discussion (‘promoting bile secretion by the liver’) of disorders causing bile acid malabsorption I 1 enteropathy. Despite more than 50 years since (BAM) including their diagnosis and treatment. the initial report, bile acid diarrhea remains an underrecognized and underappreciated cause of Bile Acid Synthesis chronic diarrhea. One report found that only 6% Bile acids are produced in the liver as end products of of British gastroenterologists investigate for bile cholesterol metabolism. Bile acid synthesis occurs acid malabsorption (BAM) as part of the first-line by two pathways: the classical (neutral) pathway testing in patients with chronic diarrhea, while 61% via microsomal cholesterol 7α-hydroxylase consider the diagnosis only in selected patients (CYP7A1), or the alternative (acidic) pathway via or not at all.2 As a consequence, many patients mitochondrial sterol 27-hydroxylase (CYP27A1). are diagnosed with other causes of diarrhea or The classical pathway, which is responsible for are considered to have irritable bowel syndrome 90-95% of bile acid synthesis in humans, begins (IBS) or functional diarrhea by exclusion, thereby with 7α-hydroxylation of cholesterol catalyzed interfering with and delaying proper treatment. -
Hepatitis A, B, and C: Learn the Differences
Hepatitis A, B, and C: Learn the Differences Hepatitis A Hepatitis B Hepatitis C caused by the hepatitis A virus (HAV) caused by the hepatitis B virus (HBV) caused by the hepatitis C virus (HCV) HAV is found in the feces (poop) of people with hepa- HBV is found in blood and certain body fluids. The virus is spread HCV is found in blood and certain body fluids. The titis A and is usually spread by close personal contact when blood or body fluid from an infected person enters the body virus is spread when blood or body fluid from an HCV- (including sex or living in the same household). It of a person who is not immune. HBV is spread through having infected person enters another person’s body. HCV can also be spread by eating food or drinking water unprotected sex with an infected person, sharing needles or is spread through sharing needles or “works” when contaminated with HAV. “works” when shooting drugs, exposure to needlesticks or sharps shooting drugs, through exposure to needlesticks on the job, or from an infected mother to her baby during birth. or sharps on the job, or sometimes from an infected How is it spread? Exposure to infected blood in ANY situation can be a risk for mother to her baby during birth. It is possible to trans- transmission. mit HCV during sex, but it is not common. • People who wish to be protected from HAV infection • All infants, children, and teens ages 0 through 18 years There is no vaccine to prevent HCV. -
Bowel Function Anatomy
BOWEL FUNCTION ANATOMY Most of America gives little thought to bowel control. However, bowel control is actually a complex process involving the coordination of many different muscles and nerves. The bowel is considered to be a part of the digestive or gastrointestinal system. It is designed to help the body absorb nutrients and fluids from the foods we eat and drink. After taking out everything the body needs, the bowel then expels the leftover waste. The beginning of the bowel is the small intestine, sometimes referred to as the small bowel. This is where the useful nutrients are absorbed from what you eat. The small bowel delivers the waste to the colon, or large bowel. The colon is a 5-6 foot long muscular tube that delivers stool to the rectum. As the stool moves through the colon, the fluids are removed and absorbed into the body. The consistency of the stool is dependent upon many things, including how long the stool sits in the colon, how much of the water has been absorbed from the waste, and the amount of fiber and fluids in your diet. Stool consistency can vary from hard lumps to mushy to very loose, watery stool. The best and easiest consistency of stool is soft, like toothpaste; this consistency may be attained by adding fiber to your diet. Fiber helps move waste through the colon because it is indigestible by the human body. In other words, fiber adds ‘bulk’ to the stool. It is important to eat a diet high in fiber, however, most Americans lack fiber in their diet. -
Active Peptic Ulcer Disease in Patients with Hepatitis C Virus-Related Cirrhosis: the Role of Helicobacter Pylori Infection and Portal Hypertensive Gastropathy
dore.qxd 7/19/2004 11:24 AM Page 521 View metadata, citation and similar papers at core.ac.uk ORIGINAL ARTICLE brought to you by CORE provided by Crossref Active peptic ulcer disease in patients with hepatitis C virus-related cirrhosis: The role of Helicobacter pylori infection and portal hypertensive gastropathy Maria Pina Dore MD PhD, Daniela Mura MD, Stefania Deledda MD, Emmanouil Maragkoudakis MD, Antonella Pironti MD, Giuseppe Realdi MD MP Dore, D Mura, S Deledda, E Maragkoudakis, Ulcère gastroduodénal évolutif chez les A Pironti, G Realdi. Active peptic ulcer disease in patients patients atteints de cirrhose liée au HCV : Le with hepatitis C virus-related cirrhosis: The role of Helicobacter pylori infection and portal hypertensive rôle de l’infection à Helicobacter pylori et de la gastropathy. Can J Gastroenterol 2004;18(8):521-524. gastropathie liée à l’hypertension portale BACKGROUND & AIM: The relationship between Helicobacter HISTORIQUE ET BUT : Le lien entre l’infection à Helicobacter pylori pylori infection and peptic ulcer disease in cirrhosis remains contro- et l’ulcère gastroduodénal dans la cirrhose reste controversé. Le but de la versial. The purpose of the present study was to investigate the role of présente étude est de vérifier le rôle de l’infection à H. pylori et de la gas- H pylori infection and portal hypertension gastropathy in the preva- tropathie liée à l’hypertension portale dans la prévalence de l’ulcère gas- lence of active peptic ulcer among dyspeptic patients with compen- troduodénal évolutif chez les patients dyspeptiques souffrant d’une sated hepatitis C virus (HCV)-related cirrhosis. -
Challenges in the Management of Acute Peptic Ulcer Bleeding
Review Challenges in the management of acute peptic ulcer bleeding James Y W Lau, Alan Barkun, Dai-ming Fan, Ernst J Kuipers, Yun-sheng Yang, Francis K L Chan Acute upper gastrointestinal bleeding is a common medical emergency worldwide, a major cause of which are bleeding Lancet 2013; 381: 2033–43 peptic ulcers. Endoscopic treatment and acid suppression with proton-pump inhibitors are cornerstones in the Institute of Digestive Diseases, management of the disease, and both treatments have been shown to reduce mortality. The role of emergency surgery The Chinese University of Hong continues to diminish. In specialised centres, radiological intervention is increasingly used in patients with severe and Kong, Hong Kong, China (Prof J Y W Lau MD, recurrent bleeding who do not respond to endoscopic treatment. Despite these advances, mortality from the disorder Prof F K L Chan MD); Division of has remained at around 10%. The disease often occurs in elderly patients with frequent comorbidities who use Gastroenterology, McGill antiplatelet agents, non-steroidal anti-infl ammatory drugs, and anticoagulants. The management of such patients, University and the McGill especially those at high cardiothrombotic risk who are on anticoagulants, is a challenge for clinicians. We summarise University Health Centre, Quebec, Canada the published scientifi c literature about the management of patients with bleeding peptic ulcers, identify directions for (Prof A Barkun MD); Institute of future clinical research, and suggest how mortality can be reduced. Digestive Diseases, Xijing Hospital, Fourth Military Introduction by how participants were sampled, their inclusion Medical University, Xian, China (Prof D Fan MD); Department of Acute upper gastrointestinal bleeding is characterised by criteria, and defi nitions of case ascertainment. -
An Overview: Current Clinical Guidelines for the Evaluation, Diagnosis, Treatment, and Management of Dyspepsia$
Osteopathic Family Physician (2013) 5, 79–85 An overview: Current clinical guidelines for the evaluation, diagnosis, treatment, and management of dyspepsia$ Peter Zajac, DO, FACOFP, Abigail Holbrook, OMS IV, Maria E. Super, OMS IV, Manuel Vogt, OMS IV From University of Pikeville-Kentucky College of Osteopathic Medicine (UP-KYCOM), Pikeville, KY. KEYWORDS: Dyspeptic symptoms are very common in the general population. Expert consensus has proposed to Dyspepsia; define dyspepsia as pain or discomfort centered in the upper abdomen. The more common causes of Functional dyspepsia dyspepsia include peptic ulcer disease, gastritis, and gastroesophageal reflux disease.4 At some point in (FD); life most individuals will experience some sort of transient epigastric pain. This paper will provide an Gastritis; overview of the current guidelines for the evaluation, diagnosis, treatment, and management of Gastroesophageal dyspepsia in a clinical setting. reflux disease (GERD); r 2013 Elsevier Ltd All rights reserved. Nonulcer dyspepsia (NUD); Osteopathic manipulative medicine (OMM); Peptic ulcer disease (PUD); Somatic dysfunction Dyspeptic symptoms are very common in the general common causes of dyspepsia include peptic ulcer disease population, affecting an estimated 20% of persons in the (PUD), gastritis, and gastroesophageal reflux disease United States.1 While a good number of these individuals (GERD).4 However, it is not unusual for a complete may never seek medical care, a significant proportion will investigation to fail to reveal significant organic findings, eventually proceed to see their family physician. Several and the patient is then considered to have “functional reports exist on the prevalence and impact of dyspepsia in the dyspepsia.”5,6 The term “functional” is usually applied to general population.2,3 However, the results of these studies disorders or syndromes where the body’s normal activities in are strongly influenced by criteria used to define dyspepsia. -
Viral Gastroenteritis Backgrounder
Viral Gastroenteritis Backgrounder Viral Gastroenteritis What is Viral Gastroenteritis? Viral gastroenteritis is a stomach illness (including diarrhea and vomiting) in people that is caused by a virus. It is commonly found throughout North America and Europe, and though it can occur year-round, this illness is most often reported in winter. These viruses can also be easily spread in situations of communal living. Viruses are very different from bacteria and parasites. Viruses are much smaller, are not affected by treatment with antibiotics. What are the symptoms of viral gastroenteritis illness? The symptoms of gastroenteritis illness usually include nausea, vomiting, diarrhea, and some stomach cramping. Sometimes people also have a low-grade fever, chills, headache, muscle aches, and a general sense of tiredness. The illness often begins suddenly, and the infected person may feel very sick. The illness is usually brief, with symptoms usually lasting only about 1 or 2 days. In general, children experience more vomiting than adults. Most people with this type of illness have both vomiting and diarrhea. How serious is viral gastroenteritis? Though this type of illness is usually not serious, some people may feel very sick and vomit or have watery diarrhea many times a day. Most people get better within 1 or 2 days, and have no long-term health effects related to their illness; however, if the ill person is unable to drink enough liquids to replace the liquids they lost because of vomiting and diarrhea, they can become dehydrated and may need special medical attention. This problem with dehydration is usually only seen among the very young, the elderly, and persons with weakened immune systems. -
Hepatitis a Reporting Guideline
Hepatitis A Signs and • Abrupt onset of fever, headache, malaise, anorexia, vomiting, diarrhea, abdominal pain Symptoms • Jaundice • Rare fatalities, particularly risk if chronic liver disease including chronic hepatitis B or C • Younger children and very rare adults may have asymptomatic infection Incubation 15–50 days, with an average of 30 days Case Clinical: acute illness, discrete onset of a consistent symptoms (fever, headache, nausea, diarrhea, classification anorexia, vomiting, abdominal pain) and either jaundice (bilirubin ≥ 3.0) or elevated ALT (≥ 200) Confirmed: Clinical & either IgM or PCR positive OR clinical with epi link to a confirmed case Differential Hepatitis B or C (do tests), chemical hepatitis (e.g., alcohol, some medications, natural products), diagnosis autoimmune hepatitis, biliary disease (gallstones), malignancy, metabolic (e.g., Wilson’s) Treatment Supportive Duration Illness may be prolonged or relapse for months with continued virus excretion; communicable before onset until asymptomatic although longer excretion in children and if relapses Exposures Contaminated food or water, particularly during travel; contact with a case (household, sexual) Laboratory • Serologic testing is available commercially; CDC genotypes for outbreak Testing • Spin serum, separate, freeze, send to PHL. CDE will complete special CDC manifest. See: https://www.cdc.gov/laboratory/specimen-submission/pdf/form-50-34.pdf. Public • Identify potential sources of exposure: close contact with acute hepatitis A case, restaurant or Health -
GASTROINTESTINAL COMPLAINT Nausea, Vomiting, Or Diarrhea (For Abdominal Pain – Refer to SO-501) I
DESCHUTES COUNTY ADULT JAIL SO-559 L. Shane Nelson, Sheriff Standing Order Facility Provider: October 17, 2018 STANDING ORDER GASTROINTESTINAL COMPLAINT Nausea, Vomiting, or Diarrhea (for Abdominal Pain – refer to SO-501) I. ASSESSMENT a. History i. Onset and duration ii. Frequency of vomiting, nausea, or diarrhea iii. Blood in stool or black stools? Blood in emesis or coffee-ground appearance? If yes, refer to SO-510 iv. Medications taken – do they help? v. Do they have abdominal pain? If yes, refer to SO-501 Abdominal Pain. vi. Do they have other symptoms – dysuria, urinary frequency, urinary urgency, urinary incontinence, vaginal/penile discharge, hematuria, fever, chills, flank pain, abdominal/pelvic pain in females or testicular pain in males, vaginal or penile lesions/sores? (if yes to any of the above – refer to Dysuria SO-522) vii. LMP in female inmates – if unknown, obtain HCG viii. History of substance abuse? Are they withdrawing? Refer to appropriate SO based on substance history and withdrawal concerns. ix. History of IBS or other known medical causes of chronic diarrhea, nausea, or vomiting? Have prescriptions been used for this in the past? x. History of abdominal surgeries? xi. Recent exposure to others with same symptoms? b. Exam i. Obtain Vital signs, including temperature ii. If complaints of dizziness or lightheadedness with standing, obtain orthostatic VS. iii. Is there jaundice present? iv. Are there signs of dehydration – tachycardia, tachypnea, lethargy, changes in mental status, dry mucous membranes, pale skin color, decreased skin turgor? v. Are you concerned for an Acute Gastroenteritis? Supersedes: March 20, 2018 Review Date: October 2020 Total Pages: 3 1 SO-559 October 17, 2018 Symptoms Exam Viruses cause 75-90% of acute gastroenteritis here in the US. -
Acute Diarrhea in Adults WENDY BARR, MD, MPH, MSCE, and ANDREW SMITH, MD Lawrence Family Medicine Residency, Lawrence, Massachusetts
Acute Diarrhea in Adults WENDY BARR, MD, MPH, MSCE, and ANDREW SMITH, MD Lawrence Family Medicine Residency, Lawrence, Massachusetts Acute diarrhea in adults is a common problem encountered by family physicians. The most common etiology is viral gastroenteritis, a self-limited disease. Increases in travel, comorbidities, and foodborne illness lead to more bacteria- related cases of acute diarrhea. A history and physical examination evaluating for risk factors and signs of inflammatory diarrhea and/or severe dehydration can direct any needed testing and treatment. Most patients do not require labora- tory workup, and routine stool cultures are not recommended. Treatment focuses on preventing and treating dehydra- tion. Diagnostic investigation should be reserved for patients with severe dehydration or illness, persistent fever, bloody stool, or immunosuppression, and for cases of suspected nosocomial infection or outbreak. Oral rehydration therapy with early refeeding is the preferred treatment for dehydration. Antimotility agents should be avoided in patients with bloody diarrhea, but loperamide/simethicone may improve symptoms in patients with watery diarrhea. Probiotic use may shorten the duration of illness. When used appropriately, antibiotics are effective in the treatment of shigellosis, campylobacteriosis, Clostridium difficile,traveler’s diarrhea, and protozoal infections. Prevention of acute diarrhea is promoted through adequate hand washing, safe food preparation, access to clean water, and vaccinations. (Am Fam Physician. 2014;89(3):180-189. Copyright © 2014 American Academy of Family Physicians.) CME This clinical content cute diarrhea is defined as stool with compares noninflammatory and inflamma- conforms to AAFP criteria increased water content, volume, or tory acute infectious diarrhea.7,8 for continuing medical education (CME).