A Guide to Anatomy & Physiology
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Research Proposal
THE EFFECTS OF MINOCYCLINE ON SPINAL ROOT AVULSION INJURY IN RODENT MODEL: A HISTOLOGICAL STUDY By DR. TAN YEW CHIN MSurg Neurosurgery (Universiti Sains Malaysia) Dissertation Submitted in Partial Fulfillment of the Requirement for the Degree of Master of Surgery (Neurosurgery) UNIVERSITI SAINS MALAYSIA 2015 i Abstrak Pengenalan: Kecederaan saraf brakial adalah sesuatu kecederaan yang memudaratkan. Kecederaan tersebut melibatkan 5% kes-kes politrauma yang diakibatkan oleh kemalangan trafik. Matlamat utama rawatan kecederaan saraf brakial adalah pemulihan tenaga motor. Perawatan kecederaan saraf brakial secara pemindahan graf saraf boleh memberikan perlindungan kepada saraf motor. Namun begitu kesan rawatan pembedahan adalah sangat terhad. Rawatan secara perubatan perlu diberikan untuk mengekalkan fungsi yang wujud pada saraf motor. Minocycline sudah terbukti untuk membekalkan perlindungan kepada sel-sel saraf dalam penyakit angin ahmar dan penyakit pengelupasan selaput saraf. Minocycline adalah antibiotik yang mudah didapati, ekonomik, dan berupaya untuk merawat radangan dan kerosakan sel sel saraf. Literasi saintifik telah menunjukkan bahawa Minocycline berupaya untuk menghasilkan kesan perlindungan kepada sel-sel saraf motor dengan prencatan sel microglia dan Nitric Oxide Synthase. Kedua-dua kesan terapiutik ini dapat mengurangkan radangan dan degenerasi saraf setelah mendapat kecederaan ‘avulsion’ saraf brakial. Objektif: Kajian ini adalah untuk mengkaji kesan Minocycline yang selama ini digunakan sebagai antibiotik kepada hayat sel saraf motor dan juga penghasilan sel Microglia. Metodologi: Kajian eksperimental ini menggunakan tikus dewasa Sprague Dawley di mana urat saraf segmen C7 tikus ditarik sehingga putus daripada saraf tunjang. Transeksi fizikal ini akan dipastikan untuk berlaku sebelum ganglion saraf. Untuk mendapatkan validasi saintifik, saraf yang terputus telah diperhatikan di bawah ii Mikroskop untuk memastikan akar-akar saraf dicabut bersama-sama dengan tangkainya. -
Anatomy & Physiology Manual Anatomy
Anatomy & Physiology Manual For Gateway Students ©Gateway Workshops Ltd™ Student Name______________________ GW It is of primary importance for the therapist to have a good knowledge of Anatomy & Physiology (A&P) so that treatments can be targeted effectively and so that undue harm cannot be caused to the client. It is also helpful to have this knowledge so that the therapist does not make any current medical conditions worse. This section provides students with essential A&P to ensure that they are able to practice with an awareness of how the body’s systems and physiology function to obtain the best possible outcome for the treatment and to recognise important contra-indications as and when they present from clients. The areas covered by this section are: 1. The structure and function of the hair and skin Page 3-8 2. The skeletal System Page 9–19 3. The Muscular System Page 20–30 4. The Respiratory System Page 31-34 5. The Cardio-Vascular/Circulatory System Page 35-37 6. The Lymphatic System Page 38-46 7. The Digestive System Page 47-50 8. The Brain & Nervous System Page 51-57 9. System Benefits of Massage Page 58 All text/script/images are copyright of © Gateway Workshops Ltd ™ April 2008 No unauthorised copying or reproduction is allowed without our written permission. 2 The Structure and function of the skin and hair Skin The skin is an ever-changing organ that contains many specialized cells and structures. The skin functions as a protective barrier that interfaces with a sometimes-hostile environment. It is also very involved in maintaining the proper temperature for the body to function well. -
Brachial Plexus Injuries in Sport Medicine: Clinical Evaluation, Diagnostic Approaches, Treatment Options, and Rehabilitative Interventions
Journal of Functional Morphology and Kinesiology Review Brachial Plexus Injuries in Sport Medicine: Clinical Evaluation, Diagnostic Approaches, Treatment Options, and Rehabilitative Interventions Immacolata Belviso 1, Stefano Palermi 1, Anna Maria Sacco 1, Veronica Romano 1, Bruno Corrado 1 , Marcello Zappia 2,3 and Felice Sirico 1,* 1 Department of Public Health, University of Naples “Federico II”, 80131 Naples, Italy; [email protected] (I.B.); [email protected] (S.P.); [email protected] (A.M.S.); [email protected] (V.R.); [email protected] (B.C.) 2 Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy; [email protected] 3 Musculoskeletal Radiology Unit, Varelli Institute, 80126 Naples, Italy * Correspondence: [email protected]; Tel.: +39-081-746-3508 Received: 1 March 2020; Accepted: 26 March 2020; Published: 30 March 2020 Abstract: The brachial plexus represents a complex anatomical structure in the upper limb. This “network” of peripheral nerves permits the rearrangement of motor efferent fibers, coming from different spinal nerves, in several terminal branches directed to upper limb muscles. Moreover, afferent information coming from different cutaneous regions in upper limb are sorted in different spinal nerves through the brachial plexus. Severe brachial plexus injuries are a rare clinical condition in the general population and in sport medicine, but with dramatic consequences on the motor and sensory functions of the upper limb. In some sports, like martial arts, milder injuries of the brachial plexus can occur, with transient symptoms and with a full recovery. Clinical evaluation represents the cornerstone in the assessment of the athletes with brachial plexus injuries. -
Alimentary System 1. Oral Cavity Lips Muscles
Alimentary system 1. Oral cavity Lips muscles: orbicularis oris, sup.&inf. Labial muscles, buccinator muscle Masticatory muscles: masseter, medial & lateral pterygoids, temporal Superior and inferior labii muscles are covered externally by skin and internally by mucous membrane. The mucous membrane covers the intraoral vestibular part of lips – pars mucosae. Cheeks have the same structure as the lips – they are the visible walls of the oral cavity. Oral cavity: (a) oral vestibule b/w teeth and buccal gingival – controlled by sphincters, orbicularis oris, buccinator, levator & depressor of lips. isthmus of hallucis opens into middle part of pharynx Borders: roof: palate floor: tongue and the mucosa (supported by geniohyoid and mylohyoid muscles) lateral&ant.: lips & cheeks. Post: oropharynx, inner body wall (teeth and gums) (b) Oral cavity proper: area inside teeth and ginigiva b/w upper & lower dental arch. Submandibular and sublingual ducts open. Oral vestibule: between lips and cheeks (teeth and buccal gingival) – opening of parotid duct in upper 2nd molar tooth. Oral opening controlled by the sphincters, osbicularis oris, biccinator, levator and depressor of lips. 2. Teeth The teeth have different surfaces: (A) inner – palatine (only for upper teeth), lingual (for both upper and lower). (B) opposite surface: facing toward the lips or toward the cheeks (buccal surface – molar or premolar teeth). (C) masticatory – for molar and premolar only. Structure of teeth: enamel: covers the crown, the hardest substance. Bentin: hard substance lining central pulp space Pulp: fills the central cavity which continues the root canal. Contains blood vessels, nerves, lymphatics (enter the pulp through apical foramen at the apex of the root). -
Illustrated Clinical Anatomy, Second Edition
Illustrated Clinical Anatomy This page intentionally left blank Illustrated Clinical Anatomy 2nd Edition Peter H. Abrahams MB BS FRCS(ED) FRCR DO (HON) Professor of Clinical Anatomy, Warwick Medical School, UK Director of Anatomy, West Midlands Surgical Training Centre, UHCW NHS Trust Extraordinary Professor, Department of Anatomy, University of Pretoria, South Africa Fellow, Girton College, Cambridge Professor of Clinical Anatomy, St George’s University, Grenada, West Indies Examiner to the Royal College of Surgeons, UK Family Practitioner, Brent, London, UK John L. Craven MD FRCS Formerly Consultant Surgeon, York District Hospital and past Chairman of the Primary Examiners of the Royal College of Surgeons of England, UK John S.P. Lumley MS FRCS FMAA (HON) FGA Emeritus Professor of Vascular Surgery, University of London Past Council Member and Chairman of Primary Fellowship Examiners, Royal College of Surgeons of England, UK Consultant Radiological Advisor: Jonathan D. Spratt BM BCHIR MA (CANTAB) FRCS (ENG) FRCS(GLAS) FRCR Clinical Director of Radiology, University Hospital of North Durham; Honorary Lecturer in Anatomy, University of Durham; Examiner in Anatomy, Royal College of Surgeons of England, UK First published in Great Britain in 2005 by Hodder Arnold This second edition published in 2011 by Hodder Arnold, an imprint of Hodder Education, a division of Hachette UK, 338 Euston Road, London NW1 3BH http://www.hodderarnold.com © 2011 Peter Abrahams, John Craven, John Lumley The illustrations listed in the acknowledgement page are © St Bartholomew’s Hospital and the Royal London School of Medicine and Dentistry of Queen Mary and Westfield College, London, 2005 All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronically or mechanically, including photocopying, recording or any information storage or retrieval system, without either prior permission in writing from the publisher or a licence permitting restricted copying.