Dr. Raj Kumar Designation: Associate Professor

Name: Dr. Raj Kumar Designation: Associate Professor (Coordinator of Centre) Centre: Pharmaceutical Sciences and Natural Products (Formerly known as Chemical and Pharmaceutical Sciences) School: Basic and Applied Sciences Central University of Punjab Bathinda-151001 Email Id: [email protected]; [email protected] Mobile:+91-9914567224/0164-2864215

Education Course Institution Year Details Ph.D. National Institute of Pharmaceutical Education and 2007 Medicinal Chemistry (With Course Research (NIPER), Mohali, India work) National Institute of Pharmaceutical Education and M.S. (Pharm.) 2002 Medicinal Chemistry Research (NIPER), Mohali, India B. Pharmacy M. D. University, Rohtak 2001 Pharmaceutical Sciences

Experience Institution Designation Duration Role Teaching (Organic and Pharmaceutical Sciences and Natural Associate 28-12-2015 Medicinal) and Research Products Professor to present

Pharmaceutical Sciences and Natural Teaching (Organic and Products (Formerly known as Centre for Assistant April 2011- Medicinal) and Research Chemical and Pharmaceutical Sciences), Professor 27-12-2015

Central University of Punjab, Bathinda, India Teaching and Research Indo-Soviet Friendship (ISF) College of Assistant 2009-2011 (Organic and Pharmaceutical Pharmacy, Moga, Punjab, India Professor Jan-April Chemistry) Assistant Research University of Maryland Baltimore County Research 2007-2008 (Synthesis of NCEs as (UMBC), USA Scientist Anticancer agents ) Research National Institute of Pharmaceutical Senior (Synthesis of NCEs as PDE4 Education and Research (NIPER), Mohali, Research 2003-2007 Inhibitors) in collaboration India Fellow with Ranbaxy Research Laboratories 2003 Research Dr. Reddy’s Laboratories, Hyderabad Chemist February- (Synthesis of novel anti- August infective agents)

Teaching Assignments  Organic Chemistry/Spectral analysis/Logics of Organic Synthesis – I and II (undergraduate level and postgraduate level).  Introduction to Medicinal Chemistry (postgraduate level).  Medicinal Chemistry of Anticancer Agents (postgraduate level) Research Project Handled  Research(Synthesis of NCEs as PDE4 Inhibitors) in collaboration with Ranbaxy Research Laboratories  Synthesis of novel anti-infective agents  Synthesis of novel COX-1/COX-2 inhibitors  Synthesis of novel Xanthine Oxidase inhibitors  Synthesis of NCEs as Anticancer agents via EGFR/HDAC/APE-1/topoisomerase/tubulin inhibition

Ongoing 1. Design, Synthesis and Biological Screening of Novel Multi-target Inhibitors of Tyrosine Kinase(s) and Topoisomerase-I - Department of Science and Technology (DST), Delhi, under the SERB Fast Track Scheme for Young Scientist-27 Lakhs 2. Design, Synthesis and Biological Screening of Novel Heterocycles as Inhibitors of Dual Tyrosine Kinase(s) and Histone Deacetylase as Potential Anticancer Agents – UGC-Major, Delhi, sanctioned money: Rs/-12,59,000 3. Design, synthesis and in vitro screening of mono-/bis- aminoquinolines as EGFR inhibitors-Research Seed Money, Central University of Punjab, Bathinda: Rs/-3,00,000 Professional Recognition /Awards/Scholarship  Research award (2014-15) from Honourable Chancellor of Central University of Punjab, Bathinda on dated 28 February, 2016 (Foundation Day).

 Resource person at 2nd APTI at organized by Govt Polytechnic College, Patiala, Punjab, March 18-19, 2016  An Expert Member in Board of studies (Pharmacy) and Faculty of Pharmacy from 01-10-2015 – 30-09-2017 at Maharaja Ranjit Singh State Technical University, Bathinda (MRSSTU).  Member, School Board of the School of Basic and Applied Sciences from 05-01-16-present at Central University of Punjab, Bathinda  Member, Board of Studies (Centre for Chemical and Pharmaceutical Sciences) from November 2014- 2015-present at Central University of Punjab, Bathinda.  Chairperson, Board of Studies (Centre for Chemical and Pharmaceutical Sciences) from November 2014- 2015 at Central University of Punjab, Bathinda.  An Expert Member in Board of studies (Pharmacy) from December 2011- present at PTU, Jalandhar  Chairperson at UGC sponsored seminar on “Green Chemistry” organized at GHG Khalsa College, Gursar Sadhar, Punjab, and February 24-25, 2012.  Life Member-Chemical Research Society of India  Life Member-IPGA  ACS member  Chairperson at APTI-16th Annual National Convention 2011 organized at I.S.F. College of Pharmacy, Moga, Punjab, India, October 7-9, 2011  Most Cited Paper 2004-2007 Award for Tetrahedron Lett.,2005,46, 1721-1724.  Most Cited Paper 2005-2008 Award for Tetrahedron Lett.,2005,46, 1721-1724.  Qualified National Eligibility Test for Lectureship in Chemical Sciences (CSIR-NET June 2002, conducted by Council for Scientific and Industrial Research, New Delhi, India)  Qualified Graduate Aptitude Test for Engineering (GATE 2001) with 99.08 percentile (All India 30th Rank); an essential requirement for getting scholarship during M. S. Pharm. course)  University Gold Medal in Bachelor of Pharmacy.

Peer Recognition 1. Lead Guest Editor of Special Issue on “Signal Transduction Inhibitors as Promising Anticancer Agents” Bio Med Research International (http://www.hindawi.com/journals/bmri/si/636318/cfp/) 2. Reviewer to Molecular Biosystems (RSC) 3. Reviewer to MedChemCom (RSC) 4. Reviewer to Bioorganic and Medicinal Chemistry (BMC, Elsevier) 5. Reviewer to Bioorganic and Medicinal Chemistry Letters (BMC, Elsevier) 6. Reviewer to Food and Chemical Toxicology (FCT, Elsevier) 7. Reviewer to European Journal of Medicinal Chemistry (EJMC, Elsevier) 8. Reviewer to International Journal of Biological Macromolecules (Elsevier) 9. Reviewer to Medicinal Chemistry Research (Springer) 10. Reviewer to Mini Reviews in Medicinal Chemistry (Benthem) 11. Reviewer to Journal of Enzyme Inhibition and Medicinal Chemistry (Informa healthcare) 12. Reviewer to Letters in Drug Design & Discovery (Bentham science) 13. Reviewer to Biomarkers in Cancer (Libertas Academica) 14. Reviewer to Drug Target Insights (Libertas Academica) 15. Reviewer to Organic Chemistry Insights (Libertas Academica) 16. Associate Editor to Pharamaceutica Analytica Acta (www.omicsonline.org) 17. Reviewer to the Grant agency: Czech Republic Foundation. 18. Reviewer to the Grant agency: Department of Science and Technology, SERB

Area specializations/Research Interest  Design and Synthesis of novel small heterocycles as anticancer, antimalarial and xanthine oxidase inhibitors.  Synthesis and methodology development of small bioactive molecules.

Publications (h index = 21; Google scholar), total impact factor:120 Research Papers

Year 2016 1. Synthesis and biological evaluation of new 2, 5-dimethylthiophene/furan based N-acetyl pyrazolines as selective topoisomerase II inhibitors. Darpan, G Joshi, SM Amrutkar, AT Baviskar, H Kler, S Singh, UC Banerjee, R Kumar*. RSC Adv, 2016, DOI: 10.1039/C5RA25705K. (I.F.:3.84). http://pubs.rsc.org/en/content/articlelanding/2016/ra/c5ra25705k#!divAbstract Year 2015 2. Imine/amide–imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-α inhibition. ANegi, JM Alex, SM Amrutkar, AT Baviskar, G Joshi, S Singh, UC Banerjee, R Kumar*. Bioorganic & medicinal chemistry, 2015, 23, 5654–5661. (I.F.:2.951). http://www.sciencedirect.com/science/article/pii/S0968089615006033.

3. Editorial Signal Transduction Inhibitors as Promising Anticancer Agent. R Kumar*, CS Dos, TS Ahluwalia, S Singh. BioMed Research International, 2015, 58, 1-10. (I.F.:2.706). http://www.hindawi.com/journals/bmri/2015/584170/ 4. Design, Microwave-mediated Synthesis and Biological Evaluation of Novel 4- Aryl(alkyl)amino-3-nitroquinoline and 2,4-Diaryl(dialkyl)amino-3-nitroquinolines as Anticancer Agents. M Chauhan, A Rana, JM Alex, A Negi, S Singh, R Kumar*. Bioorganic Chemistry, 2015, 58, 1-10. (I.F.:2.141).http://www.sciencedirect.com/science/article/pii/S0045206814001102

Year 2014 5. Synthesis and Xanthine Oxidase Inhibitory Activity of 5, 6-Dihydropyrazolo/pyrazolo [1, 5-c] quinazoline Derivatives. D Kumar, G Kaur, A Negi, S Kumar, S Singh, R Kumar*. Bioorganic Chemistry, 2014. 57, 57-64 (I.F.:2.141)http://www.sciencedirect.com/science/article/pii/S0045206814000741 6. 1‐Acetyl‐3, 5‐diaryl‐4, 5‐dihydro (1H) pyrazoles: Exhibiting Anticancer Activity through Intracellular ROS Scavenging and the Mitochondria‐Dependent Death Pathway. JM Alex, S Singh, R Kumar*. Archiv der Pharmazie, 2014, 347, 1–11 (I.F.:1.396)http://onlinelibrary.wiley.com/doi/10.1002/ardp.201400199/full 7. 2-(2-Arylphenyl) benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation. K Seth, SK Garg, R Kumar, P Purohit, VS Meena, R Goyal, UC Banerjee. ACS Medicinal Chemistry Letters, 2014, 5, 512–516 (I.F.:3.073; Citations: 2)http://pubs.acs.org/doi/abs/10.1021/ml400500e 8. Microwave-assisted synthesis of pyrazolo [1, 5-c] quinazolines and their derivatives. D Kumar, R Kumar*. Tetrahedron Letters, 2014, 55, 2679-2683. (I.F: 2.391; Citations: 1)http://www.sciencedirect.com/science/article/pii/S0040403914004353

Year 2013

9. Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity. AT Baviskar, UC Banerjee, M Gupta, R Singh, S Kumar, MK Gupta, R Kumar*. Bioorganic & medicinal chemistry, 2013, 21, 5782-5793. (I.F.:2.951; Citations: 3)http://www.sciencedirect.com/science/article/pii/S0968089613006275 10. Selectivity control during the solid supported protic acids catalysed synthesis of 1, 2- disubstituted benzimidazoles and mechanistic insight to rationalize selectivity. D Kumar, DN Kommi, R Chebolu, SK Garg, R Kumar, AK Chakraborti. RSC Advances, 2013, 3, 91- 98 (I.F.:3.708; Citations: 3)http://pubs.rsc.org/en/content/articlehtml/2013/ra/c2ra21994h 11. Cystathionine β-Lyase-Like Protein with Pyridoxal Binding Domain Characterized in Leishmania major by Comparative Sequence Analysis and Homology Modelling. A Negi, S Bhushan, P Gupta, P Garg, R Kumar*. ISRN Computational Biology, 2013, http://www.hindawi.com/journals/isrn/2013/520435/abs/

Year 2012 12. Intracellular delivery of redox cycler-doxorubicin to the mitochondria of cancer cell by folate receptor targeted mitocancerotropic liposomes. SS Malhi, A Budhiraja, S Arora, KR Chaudhari, K Nepali, R Kumar, H Sohi. International Journal of Pharmaceutics, 2012, 432, 63-74. (I.F: 3.785; Citations: 20). http://www.sciencedirect.com/science/article/pii/S0378517312003766 13. Synthesis of combretastatin analogs: evaluation of in vitro anticancer activity and molecular docking studies. S Kumar, S Sapra, R Kumar, MK Gupta, S Koul, T Kour, AK Saxena. Medicinal Chemistry Research, 2012, 21, 3720-3729. (I.F.:1.6; Citations: 4)http://link.springer.com/article/10.1007/s00044-011-9887-7#page-1 14. Effect of nitrogen insertion on the antitussive properties of menthol and camphor. N Kumar, K Nepali, S Sapra, KRV Bijjem, R Kumar*.OP Suri, KL Dhar. Medicinal Chemistry Research, 2012, 21, 531-537. (I.F.:1.6; Citations: 3)http://link.springer.com/article/10.1007/s00044-011-9560-1#page-1

Year 2011 15. N-(1, 3-Diaryl-3-oxopropyl) amides as a new template for xanthine oxidase inhibitors. K Nepali, A Agarwal, S Sapra, V Mittal, R Kumar*.UC Banerjee, MK Gupta. Bioorganic &medicinal chemistry, 2011, 19, 5569-5576. (I.F.:2.951; Citations: 19) 16. A rational approach for the design and synthesis of 1-acetyl-3, 5-diaryl-4, 5-dihydro (1H) pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors. K Nepali, G Singh, A Turan, A Agarwal, S Sapra, R Kumar*.UC Banerjee. Bioorganic & medicinal chemistry, 2011, 19, 1950-1958. (I.F.:2.951; Citations: 35http://www.sciencedirect.com/science/article/pii/S0968089611000873

Year 2010 17. Synthesis and biological evaluation of arylidene analogues of Meldrum’s acid as a new class of antimalarial and antioxidant agents. HS Sandhu, S Sapra, M Gupta, K Nepali, R Gautam, S Yadav, R Kumar*.Bioorganic & medicinal chemistry, 2010, 18 (15), 5626- 5633. (I.F.:2.951; Citations: 6)http://www.sciencedirect.com/science/article/pii/S0968089610005614 18. Analysis of Mentha waste products using GC-MS. S Sapra, K Nepali, R Kumar, R Goyal, OP Suri, VK Koul, KL Dhar. Int. J. Pharm. Sci. Res 2010, 1 (4), 53-55. (I.F: 1.351; Citations: 1)http://ijpsr.com/V1I4/4%20Vol%201%20Issue%204%20Paper%201.pdf 19. Novel, Broad Spectrum Anticancer Agents Containing the Tricyclic 5: 7: 5-Fused Diimidazodiazepine Ring System. A Kondaskar, S Kondaskar, R Kumar, JC Fishbein, N Muvarak. ACS medicinal chemistry letters,2010,2 (3), 252-256. (I.F.:3.073;Citations: 7)http://pubs.acs.org/doi/abs/10.1021/ml100281b

Year 2008 20. Fluoroboric acid adsorbed on silica-gel (HBF4–SiO2) as a new, highly efficient and reusable heterogeneous catalyst for thia-Michael addition to α, β-unsaturated carbonyl compounds. G Sharma, R Kumar, AK Chakraborti. Tetrahedron Letters, 2008, 49 (27), 4272-4275. (I.F: 2.391; Citations: 59)http://www.sciencedirect.com/science/article/pii/S0040403908008265 21. ‘On water’synthesis of 2, 4-diaryl-2, 3-dihydro-1, 5-benzothiazepines catalysed by sodium dodecyl sulfate (SDS). G Sharma, R Kumar, AK Chakraborti. Tetrahedron Letters 2008, 49 (27), 4269-4271. (I.F: 2.391; Citations: 58)http://www.sciencedirect.com/science/article/pii/S0040403908008277 22. Tetrafluoroboric acid adsorbed on silica gel as a reusable heterogeneous dual-purpose catalyst for conversion of aldehydes/ketones into acetals/ketals and back again. D Kumar, R Kumar, AK Chakraborti. Synthesis 2008 (08), 1249-1256. (I.F: 2.443; Citations: 11)https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2008-1042940 23. The first synthesis of a novel 5: 7: 5-fused diimidazodiazepine ring system and some of its chemical properties. R Kumar, RK Ujjinamatada, RS Hosmane. Organic letters, 2008, 10 (20), 4681-4684. (I.F.: 6.324; Citations: 4)http://www.hindawi.com/journals/isrn/2013/520435/abs/

Year 2007 24. A novel environmentally friendly process for carbon–sulfur bond formation catalyzed by montmorillonite clays. G Sharma, R Kumar, AK Chakraborti. Journal of Molecular Catalysis A: Chemical 2007, 263 (1), 143-148. (I.F: 3.679; Citations: 42)http://www.sciencedirect.com/science/article/pii/S1381116906011174 25. LC and LC-MS study of stress decomposition behaviour of isoniazid and establishment of validated stability-indicating assay method. H Bhutani, S Singh, S Vir, KK Bhutani, R Kumar, AK Chakraborti. Journal of pharmaceutical and biomedical analysis, 2007, 43 (4), 1213-1220. (I.F.: 2.829; Citations: 29)http://www.sciencedirect.com/science/article/pii/S0731708506007060 26. Perchloric Acid Adsorbed on Silica Gel (HClO4-SiO2) as an Inexpensive, Extremely Efficient, and Reusable Dual Catalyst System for Acetal/Ketal Formation and Their Deprotection to Aldehydes/Ketones. R Kumar, D Kumar, AK Chakraborti. Synthesis 2007 (02), 299-303. (I.F: 2.443; Citations: 29) https://www.thieme- connect.de/DOI/DOI?10.1055/s-2006-958948 27. Microwave-accelerated solvent-and catalyst-free synthesis of 4-aminoaryl/alkyl-7- chloroquinolines and 2-aminoaryl/alkylbenzothiazoles. F Motiwala, R Kumar, AK Chakraborti. Australian journal of chemistry, 2007, 60 (5), 369-374. (I.F: 1.644; Citations: 24)http://www.publish.csiro.au/?paper=CH06391 28. Magnesium perchlorate as a new and highly efficient catalyst for the synthesis of 2, 3- dihydro-1, 5-benzothiazepines. GL Khatik, R Kumar, AK Chakraborti. Synthesis, 2007, 541-546. (I.F: 2.443; Citations: 19)http://pubs.acs.org/doi/abs/10.1021/jo0605142 29. Scope and limitations of HClO4–SiO2 as an extremely efficient, inexpensive, and reusable catalyst for chemoselective carbon–sulfur bond formation. GL Khatik, G Sharma, R Kumar, AK Chakraborti. Tetrahedron, 2007, 63 (5), 1200-1210. (I.F: 2.81; Citations: 58)http://www.sciencedirect.com/science/article/pii/S0040402006018515

Year 2006 30. Catalyst-free conjugated addition of thiols to α, β-unsaturated carbonyl compounds in water. GL Khatik, R Kumar, AK Chakraborti. Organic letters, 2006, 8 (11), 2433-2436. (I.F.: 6.324; Citations: 164)http://pubs.acs.org/doi/abs/10.1021/ol060846t 31. Zinc (II) perchlorate as a new and highly efficient catalyst for formation of aldehyde 1, 1- diacetate at room temperature and under solvent-free conditions. R Kumar, R Thilagavathi, R Gulhane, AK Chakraborti. Journal of Molecular Catalysis A: Chemical, 2006, 250 (1), 226-231. (I.F: 3.679; Citations: 27)http://www.sciencedirect.com/science/article/pii/S1381116906005164 32. Cu (BF4) 2xH2O: A versatile catalyst. RK Khunger*. Synlett, 2006, 327-328. (I.F: 2.463; Citations: 1)http://www.electronicsandbooks.com/eab1/manual/Magazine/S/SynLett/2006/0327.pdf

Year 2005 33. Copper (II) tetrafluoroborate as a novel and highly efficient catalyst for Michael addition of mercaptans to α, β-unsaturated carbonyl compounds. SK Garg, R Kumar, AK Chakraborti, Tetrahedron letters, 2005, 46 (10), 1721-1724. (I.F: 2.391; Citations: 95)http://www.sciencedirect.com/science/article/pii/S0040403905000924 34. Zinc perchlorate hexahydrate catalysed conjugate addition of thiols to α, β-unsaturated ketones. SK Garg, R Kumar, AK Chakraborti. Synlett, 2005 (09), 1370-1374. (I.F: 2.463; Citations: 48)http://www.readcube.com/articles/10.1002%2Fchin.200541031 35. Copper (II) tetrafluoroborate as a novel and highly efficient catalyst for acetal formation. R Kumar, AK Chakraborti. Tetrahedron letters, 2005, 46 (48), 8319-8323. (I.F: 2.391; Citations: 38 36. Microwave-assisted direct synthesis of 2-substituted benzoxazoles from carboxylic acids under catalyst and solvent-free conditions. R Kumar, C Selvam, G Kaur, AK Chakraborti. Synlett 2005 (09), 1401-1404. (I.F: 2.463; Citations: 35)http://cat.inist.fr/?aModele=afficheN&cpsidt=16828475 37. Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA). R Thilagavathi, R Kumar, V Aparna, ME Sobhia, B Gopalakrishnan. Bioorganic & medicinal chemistry letters 2005, 15 (4), 1027-1032. (I.F.:2.951; Citations: 11)http://www.sciencedirect.com/science/article/pii/S0960894X04015021

Year 2004 38. Copper (II) Tetrafluoroborate-Catalyzed Formation of Aldehyde-1, 1-diacetates. AK Chakraborti, R Thilagavathi, R Kumar. Synthesis, 2004, (06), 831-833. (I.F: 2.443; Citations31 http://www.organic-chemistry.org/abstracts/literature/317.shtm

Book Chapters Pharmaceutical Organic Chemistry for B. Pharmacy students by S.C. Sharma and Raj Kumar, Vishal Publishing Co., Jalandhar, India, ISBN 978-81-921432-9-3

Review Articles 1. Epidermal Growth Factor Receptor (EGFR) and its Cross-talks with Topoisomerases: Challenges and Opportunities for Multi-Target Anticancer Drugs. M Chahuan, G Sharma, G Joshi and R Kumar. Current Pharmaceutical Design 2016, Accepted for Publication. (I.F.: 3.45). 2. Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases. RP Cholia, H Nayyar, R Kumar and AK Mantha. Current Molecular Medicine 2015, 15, 1-12. (I.F.: 3.621). http://europepmc.org/abstract/med/26391552 3. Misconstrued Versatility of Ganoderma lucidum: A key Player in Multi-targeted cellular signaling. B Gill, P Sharma, R Kumar and S Thakur. Tumour Biology, 2015, accepted for publication. (I.F.: 3.611). 4. Toxicophore exploration as a screening technology for drug design and discovery: Techniques, scope and limitations. PK Singh, A Negi, PK Gupta, M. Chauhan,R Kumar*. Archives of Toxicology, 2015, Accepted for Publication. (I.F.: 5.98). http://link.springer.com/article/10.1007/s00204-015-1587-5

5. Growth factors mediated cell signalling in prostate cancer progression: Implications in discovery of anti-prostate cancer agents. GJoshi, A Negi, PK Singh, S Singh, R Kumar*. Chemico-Biological Interaction, 2015, 240, 120-133. (I.F.: 2.90)http://www.sciencedirect.com/science/article/pii/S0009279715300399.

6. DNA Repair and Redox Activities and Inhibitors of APE1/Ref-1: A Comparative Analysis and their Scope and Limitations toward Anticancer Drug Development. G Kaur, R Cholia, AK Mantha, R Kumar*. Journal of Medicinal Chemistry, 2014. DOI: 10.1021/jm500865u; Accepted for publication (I.F.: 5.480)http://pubs.acs.org/doi/abs/10.1021/jm500865u 7. Pyrazoloquinazolines: Synthetic strategies and bioactivities. M Garg, M Chauhan, PK Singh, JM Alex, R Kumar*. European Journal of Medicinal Chemistry, 2014. DOI: doi:10.1016/j.ejmech.2014.11.051; Accepted for publication (I.F.: 3.40)http://www.sciencedirect.com/science/article/pii/S0223523414010927 8. A Comprehensive Review on Bioactive Fused Heterocycles as Purine Utilizing Enzymes Inhibitors. M Chauhan, R Kumar*. Medicinal Chemistry Research, 2014, Accepted for Publication (I.F.:1.6).http://link.springer.com/article/10.1007/s00044-014-1295-3#page-1

9. A review on pharmacophoric designs of antiproliferative agents. A Rana, JM Alex, M Chauhan, G Joshi, R Kumar*. Medicinal Chemistry Research, 1-18, 2014. (I.F.:1.6)http://link.springer.com/article/10.1007/s00044-014-1196-5#page-1 10. 4, 5-Dihydro-1 H-pyrazole: an indispensable scaffold. JM Alex, R Kumar*. Journal of enzyme inhibition and medicinal chemistry, 2014, 29, 427-442. (I.F.:2.383; Citations: 1)http://informahealthcare.com/doi/abs/10.3109/14756366.2013.795956 11. Medicinal attributes of pyrazolo[3, 4-d] pyrimidines: A review. M Chauhan, R Kumar*. Bioorganic & medicinal chemistry, 2013, 21, 5657-5668. (I.F.:2.951; Citations: 8)http://www.sciencedirect.com/science/article/pii/S0968089613006470 12. Recent Advancements in Small Molecule Inhibitors of Insulin–like Growth Factor-1 Receptor (IGF-1R) Tyrosine Kinase as Anticancer agents. A Negi, P Ramarao, R Kumar*. Mini reviews in medicinal chemistry, 2013, 13, 653-681. (I.F.:3.186; Citations: 5)http://www.ingentaconnect.com/content/ben/mrmc/2013/00000013/00000005/art00004 13. Xanthine oxidase inhibitors: a patent survey. R Kumar*, S Sharma, R Singh. Expert opinion on therapeutic patents, 2011, 21, 1071-1108 (I.F: 3.441; Citations: 15)http://informahealthcare.com/doi/abs/10.1517/13543776.2011.577417 14. Progress in COX-2 inhibitors: a journey so far. AK Chakraborti, SK Garg, R Kumar, HF Motiwala, PS Jadhavar. Current medicinal chemistry, 2010, 17, 1563-1593. (I.F: 3.715; Citations:61)http://www.ingentaconnect.com/content/ben/cmc/2010/00000017/00000015/a rt00006 Popular Articles 1. DNA Repair and Redox Activities and Inhibitors of APE1/Ref-1: A Comparative Analysis and their Scope and Limitations toward Anticancer Drug Development. G Kaur, R Cholia, AK Mantha, R Kumar*. Journal of Medicinal Chemistry, 2014. DOI: 10.1021/jm500865u; Accepted for publication (I.F.: 5.480) 2. Medicinal attributes of pyrazolo[3, 4-d] pyrimidines: A review. M Chauhan, R Kumar*. Bioorganic & medicinal chemistry, 2013, 21, 5657-5668. (I.F.:2.951; Citations: 8) 3. Scope and limitations of HClO4–SiO2 as an extremely efficient, inexpensive, and reusable catalyst for chemoselective carbon–sulfur bond formation. GL Khatik, G Sharma, R Kumar, AK Chakraborti. Tetrahedron, 2007, 63 (5), 1200-1210. (I.F: 2.81; Citations: 58) 4. Copper (II) tetrafluoroborate as a novel and highly efficient catalyst for Michael addition of mercaptans to α, β-unsaturated carbonyl compounds. SK Garg, R Kumar, AK Chakraborti, Tetrahedron letters, 2005, 46 (10), 1721-1724. (I.F: 2.391; Citations: 95) 5. Catalyst-free conjugated addition of thiols to α, β-unsaturated carbonyl compounds in water. GL Khatik, R Kumar, AK Chakraborti. Organic letters, 2006, 8 (11), 2433-2436. (I.F.: 6.324; Citations: 174) Workshop/Conferences Organised Three day workshop on “Drug Design, Molecular Docking, Virtual Screening and Pharmacoinformatics” 26th-28th November, 2015 at Central University of Punjab, Bathinda

Worked as Head of Registration Committee in Challenges and Opportunities for Pharmacy Graduates in 21stCentuary, Indian Pharmacy Graduates’ Association (IPGA), 2009, November 7-8 at I.S.F. College of Pharmacy, Moga, Punjab, India.

Attended 1. Dr. Raj Kumar attended orientation programme at Panjab University Chandigarh, Feb 10- March 09, 2015 2. Dr. Raj Kumar attended refresher course at Punjabi University Patiala, May 04- May 23, 2015 3. Kumar, R, M Chahuan, G Joshi and Sandeep Kumar- presented a poster at 18 CRSI, National symposium on Chemistry, 2016, held at Panjab University, Chandigarh.

4. Joshi, G, Singh, S, and Kumar, R,* presented a poster entitled “Design, Synthesis and in vitro Screening of Novel Heterocycles as Potential Anticancer Agents”, International Conference on Nascent Development in Chemical Sciences (NDCS-2015), organised by BITS Pilani, Rajasthan from 16th – 18th October, 2015. 5. Joshi, G, Singh, S, and Kumar, R,* presented a poster at 1st International Electronic Conference on Medicinal Chemistry entitled “Design, Synthesis and in vitro Screening of Pyrazolines based compounds as Phytohaemagglutinin (PHA) mimetic” 2-27 November 2015, organized by Pharmaceuticals. 6. Joshi, G, Kumar, R, attended a three-day workshop on “Drug Design, Molecular Docking, Virtual Screening and Pharmacoinformatics” 26th-28th November, 2015 organized by Central University of Punjab

7. Chauhan, M., Alex, J.M., Singh, S., Kumar, R,*Quinoline Based Inhibitors of Epidermal Growth Factor Receptor: Synthesis and In vitro Biological Evaluation, Presented on 10th International Symposium on Bio-Organic Chemistry, in association with International Union of Pure and Applied Chemistry (IUPAC) held at Indian Institute of Sciences Education and Research (IISER), Pune on 11-15 January, 2015. 8. Invited Lecture: Kumar, R,*Pyrazolo[3,4-d]pyrimidines: Synthetic strategies and biological activities, International Symposium on Recent Advances on Medicinal Chemistry (ISRAM), IL-12, NIPER, Mohali on September 8 – 10, 2014. 9. Purohit, P., Seth, K., Kumar, R, Garg, S.K., Chakraborti, A.K.NOVEL HETEROCYCLIC SCAFFOLD AS COX-2 SELECTIVE, Presented on International Symposium on Recent Advances on Medicinal Chemistry (ISRAM), NIPER, Mohali on September 8 – 10, 2014. 10. Invited Lecture; Kumar, R. Delivered lecture entitled “Design and Synthesis of Novel Ring Expanded Heterocycles and their Corresponding Nucleosides as Potential Chemotherapeutic Agents for Cancer and Viral Diseases” at Indian Institute of Science Education and Research (IISER), 2009, Jan 23. Mohali, India 11. Compounds inducing hpbmc proliferative capacity in vitro Alex, J. M., Singh, S., Kumar, R, presented at one day symposium on Recent Trend in Molecular Medicine held at CUPB on December 5, 2014 (1ST Prize). 12. Design Synthesis and in-vitro screening of novel heterocycles as potential anticancer agents, Joshi.G., Singh, S., Kumar, R, presented at one day symposium on Recent Trend in Molecular Medicine held at CUPB on December 5, 2014 (2nd Prize). 13. Kaur, G, Kumar, R,* Rationale design of APE1 DNA repair inhibitors through in silico approaches, Presented on 8th Chandigarh Science Congress, CHASCON-2014 held at Panjab University, Chandigarh on 26th-28th February 2014. 14. Kumar, R,* Rana, A., Chauhan, M., Singh, S., Microwave assisted synthesis of derivatives of 4-aminoquinolines as potential anticancer agents, Presented in 50th Annual Convention of Chemist 2013 held at Punjab University, Chandigarh on December 04-07, 2013. 15. Chauhan, M., Alex, J. M., Singh, S., Kumar, R,* An easy and greener approach for the synthesis of novel heterocyclics and their anticancer evaluation, Presented in 50th Annual Convention of Chemist 2013 held at Punjab University, Chandigarh on December 04-07, 2013. 16. Chairperson at UGC sponsored seminar on “Green Chemistry” organized at GHG Khalsa College, GursarSadhar, Punjab, February 24-25, 2012 17. Attended a National Seminar on Environment and Health, September 27, 2011 held at Central University of Punjab, Bathinda. 18. Attended 3rd NIPER-(RBL)-CDRI symposium on Medicinal Chemistry and Pharmaceutical Sciences, March 03-05, 2011 held at CDRI Lucknow. 19. A short term certificate course (from August 23, 2010 to August, 27, 2010) on Faculty Induction Training Programme conducted by Education and Educational Management, at National Institute of Technical Teachers’ Training and Research, Chandigarh. 20. Nepali, K., Agarwal A., Kumar, R.*, Banerjee, U. C., Dhar, K. L., Suri, O. P. Design, synthesis and biological evaluation of N-(3-oxo-1,3-diaryl/dihetroarylpropyl)acetamides as potential non-purine xanthine oxidase inhibitors, Abstract published in Med. Chem. Res. 2010, 19, S77. Current Trends in Drug Discovery Research 2010, February 17-21 at Central Drug Research Institute (CDRI),Lucknow. Poster No. 55. 21. Sapra, S., Sandhu, H. S., Chugh, M., Kumar, R.*,Padh, H., Shishoo, C. J., Dhar, K. L. Synthesis and antimalarial activity of arylidene derivatives of Meldrum’s acid, Abstract published in Med. Chem. Res. 2010, 19, S113. Current Trends in Drug Discovery Research 2010, February 17-21 at Central Drug Research Institute (CDRI),Lucknow. Poster No. 117. 22. Kumar, S., Gupta, M., Agarwal A., Kumar, R.*, Banerjee, U. C., Dhar, K. L. Design, syntheisis and xanthine oxidase inhibitory activities of novel 5:6-fused heterocycles, Abstract published in Med. Chem. Res. 2010, 19, S126, Current Trends in Drug Discovery Research 2010, February 17-21 at Central Drug Research Institute (CDRI),Lucknow. Poster No. 139. 23. Kalra, S., Sandhu, H. S., Sapra, S. and Kumar, R.*An account on biological potential of synthetics derivedfrom Meldrum’s acid, Challenges and Opportunities for Pharmacy Graduates in 21stCentuary, Indian Pharmacy Graduates’ Association (IPGA), 2009, November 7-8 at I.S.F. College of Pharmacy, Moga, Punjab, India. Poster No. B24. 24. Singh, P., Gupta, M., Yadav, S. K. and Kumar, R.*Synthetic purines and pyrimidines: recent entries as potential anticancer and antiviral agents, Challenges and Opportunities for Pharmacy Graduates in 21stCentuary, Indian Pharmacy Graduates’ Association (IPGA),2009, November 7-8 at I.S.F. College of Pharmacy, Moga, Punjab, India. Poster No. B25. 25. Kumar, R.Ujjinamatada, R. K. and Hosmane, R. S. The First Synthesis of a Novel 5:7:5- Fused Diimidazodiazepine Ring System and Some of its Chemical Properties, Zing Med. Chem Conference, 2009, Feb 2-4. Playa del Carmen, Mexico. 26. Khathik, G. L. Kumar, R. and Chakraborti, A. K. Co-operative Dual Activation Role of Water in Catalyst-free C-S Bond Formation, National Symposium on New Challenges in Chemistry, 2006, Mar 20 – 21. Guru Nanak Dev University, Amritsar, India Poster No. PP 23. 27. Motiwala, H. F., Kumar, R. and Chakraborti, A. K. Microwave-Assisted Catalyst and Solvent-Free Synthesis of 4-Aminoaryl Derivatives of 4,7-Dichloroquinolines, National Symposium on New Challenges in Chemistry, 2006, Mar 20 – 21. Guru Nanak Dev University, Amritsar, India Poster No. PP 24. 28. KamleshMeena, Kumar, R. Pankaj Soni, Asit K. Chakaraborti and U.C. Banerjee. Chemoenzymatic synthesis of key precursor of (S)-sotalol, Department of Biotechnology, Punjabi University, Patiala, 21 -22, March, 2006. 29. Kumar, R. and Chakraborti, A. K. An Efficient Protocol for acetal formation under the catalytic influence of Copper (II) Tetrafluoroborate hydrate, National Symposium on Chemistry, 8th CRSI 2006, Mumbai (India). 30. Kumar, R., Thilagavathi, R., Aparna V., Sobhia, M. E., Gopalakrishnan, B. and Chakraborti, A. K. 3-D QSAR Studies on Imidazolyl and N-PyrrolylHeptenoates as HMG-CoA Reductase Inhibitors, National Symposium on Chemistry, 7th CRSI 2005, Kolkata (India). 31. Garg, K. S., Kumar, R. and Chakraborti, A. K. Novel Transition Metal Derived Catalyst for Thia-Micheal Reaction.National Symposium on Chemistry, 7th CRSI 2005, Kolkata (India). 32. Chakraborti, A. K., Kondaskar, A., Kumar, R. and Rudrawar, S. Complementarity of Zeolites and Clays in Catalyzing Nucleophilic Opening of Epoxides: Applications for Synthesis of Drug and Drug Intermediates, ICOB-4 & ISCNP-24 (IUPAC International Conference on Biodiversity and Natural Products: Chemistry and Medical Applications),January 2004, Delhi (India) P-165. 33. Chakraborti, A. K., Kaur, G., Sharma, L., Magesh, S. and Kumar, R. Solution and Solid Phase Combinatorial Synthesis of Stilbene Libraries, Biotechnology-A Challenge to Pharmacy th Profession, 54 Indian Pharmaceutical Congress, December 2002, Pune (India) B1-27. Research Grants 1. Design, Synthesis and Biological Screening of Novel Multi-target Inhibitors of Tyrosine Kinase(s) and Topoisomerase-I - Department of Science and Technology (DST), Delhi, under the SERC Fast Track Scheme for Young Scientist-27 Lakhs 2. Design, Synthesis and Biological Screening of Novel Heterocycles as Inhibitors of Dual Tyrosine Kinase(s) and Histone Deacetylase as Potential Anticancer Agents – UGC-Major, Delhi, sanctioned money: Rs/-12,59,000 3. Design, synthesis and in vitro screening of mono-/bis- aminoquinolines as EGFR inhibitors- Research Seed Money, Central University of Punjab, Bathinda: Rs/-3,00,000

Other Achievements (a) M. Pharm. thesis Supervised

1. Title: “Design and Synthesis of 1-Acetyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazoles as a New Class of Non-purine Xanthine Oxidase Inhibitors”- M. Pharm. degree awarded to Mr. Anil Turan (MDU Regn No: 99-RUR-246) in August 2010. 2. Title: “Design and Synthesis of Some New Purine based Allopurinol Analogues as Xanthine Oxidase Inhibitors”- M. Pharm. degree awarded to Mr. Mukesh Gupta (PTU Regn No: 80404446008) in August 2010. 3. Title: “Synthesis and Biological Evaluation of Arylidene Analogues of Meldrum’s acid as a New Class of Antimalarial and Antioxidant Agents”- M. Pharm. degree awarded to Mr. Harmeet Singh Sandhu (PTU Regn No: 80404446002) in August 2010. 4. Title: “Synthesis and Biological Evaluation of Novel 5:6/5:7:6-Fused Heterocycles as Anticancer Agents”- M. Pharm. degree awarded to Mr. Rajveer Singh (PTU Regn No: 96065181126) in August 2011. 5. Title: “Synthesis and Evaluation of New N-Heterocycles as Potential Anticancer Agents and Xanthine Oxidase Inhibitors”- M. Pharm. degree awarded to Mr. Darpan (PTU Regn No: 96065181116) in August 2011. 6. Title: “Synthesis and Biological Evaluation of Novel Heterocycles as Potential Anticancer Agents”- M. Pharm. degree awarded to Mr. Sahil Sharma (PTU Regn No: 96065181128) in August 2011. 7. Title: “Imidazole based compounds: Synthesis and in vitro anticancer screening”- M. Pharm. , Thesis submitted in August 2013 by Mr. Arvind Negi (Central University of Punjab Regn No: CUP/Mphm-PhD/SBAS/CPS/2011/01). 8. Title: “Synthesis and Evaluation of Novel Heterocyclics as Anticancer Agents”- M. Pharm. , Thesis submitted in August 2013 by Miss Monika Chauhan (Central University of Punjab Regn No: CUP/Mphm-PhD/SBAS/CPS/2011/04)). 9. Title: “Synthesis and Biochemical Screening of Novel Non-Purine Based Xanthine Oxidase Inhibitors”- M. Pharm. Thesis submitted in August 2013 by Mr. Deependra Kumar (Central University of Punjab Regn No: CUP/Mphm-PhD/SBAS/CPS/2011/06). 10. Title: “Anticancer potential of new N-acetyl pyrazoline derivatives of 1, 3-diaryl/heteroaryl propenones: Synthesis and evaluation”- M. Pharm., Thesis submitted in August 2013 by Miss Jimi Marin Alex (Central University of Punjab Regn No: CUP/M.Pham-Ph.D/SBAS/CPS/2011- 12/02). 11. Title: “Synthesis of mono- and bis-aminoquinoline compounds as potential anticancer agents”- Mr. Anil Rana (Central University of Punjab Regn No: CUPB/M.PHARM-MC/SBAS/CPS/2012- 13/08). Thesis submitted in August 2014 12. Title: “Design and synthesis of pyrazolo [1,5-c] quinazoline based anticancer agents”- Mr. Gaurav Joshi (Central University of Punjab Regn No: CUPB/M-PHARM-MC/SBAS/CPS/2012-13/02). Thesis submitted in August 2014 13. Title: “Design and synthesis of ape1 inhibitors as putative anticancer agents”- Miss Gagandeep Kaur (Central University of Punjab Regn No: CUPB/M-PHARM-MC/SBAS/CPS/2012-13/04). Thesis submitted in August 2014 14. Title: “Synthesis and biological evaluation of pyrazoloquinazolinescaffolds as putative anti-cancer agents”- Candidate: Mr. Pankaj Kumar Singh (CUPB/MPharm-MC/SBAS/CPS/2013-14/06). 15. Title: “Synthesis and biological evaluation of pyrimidine based analogues as anticancer agents”- Candidate: Mr. Himanshu Nayyar (CUPB/MPharm-MC/SBAS/CPS/2013-14/08). 16. Title: “Synthesis and evaluation of quinolone based compounds as putative anticancer agents”- Candidate: Ms. Archna Kashyap (CUPB/MPharm-MC/SBAS/CPS/2013-14/01).

(b) M. Sc. dissertation Supervised

1. Title: “Identification of new xanthine oxidase inhibitors based on virtual screening”- Candidate: Ms. HarveenKler(CUPB/MSc/SBAS/CPS/2013-14/05). 2. Title: “Identification of new small molecules as Insulin growth factor receptor-1 inhibitor through virtual screening”- Candidate: Ms. Mansi Garg (CUPB/MSc/SBAS/CPS/2013-14/06).

1. Title: “Synthesis and biological evaluation of pyrazoloquinazolinescaffolds as putative anti-cancer agents”- Candidate: Mr. Pankaj Kumar Singh (CUPB/MPharm-MC/SBAS/CPS/2013-14/06). 2. Title: “Synthesis and biological evaluation of pyrimidine based analogues as anticancer agents”- Candidate: Mr. HimanshuNayyar (CUPB/MPharm-MC/SBAS/CPS/2013-14/08). 3. Title: “Synthesis and evaluation of quinolone based compounds as putative anticancer agents”- Candidate: Ms. ArchnaKashyap (CUPB/MPharm-MC/SBAS/CPS/2013-14/01).

(d) Ph.D. students enrolled (under Supervision) -2, under co-supervision-1 Collaboration 1. Professor U.C. Banerjee, Department of Pharmaceutical Technology (Biotechnology), NIPER, Mohali 2. Dr. Sandeep Singh, Centre for Genetic Diseases and Molecular Medicine, Central University of Punjab, Bathinda 3. Dr. Anil K. Mantha, Centre for Biosciences, Central University of Punjab, Bathinda

Patents Filed

1. Title: Novel 5:7:5 Fused Tricyclic Heterocycles and Nucleosides with Potential Anticancer and Antiviral Properties. Inventors: Hosmane, R. S., Kumar, R., Ujjinamatada, R., Provisional US patent, International application no. PCT/US2009/005273. Published and available online. 2. Title: Novel Cyclooxygenase-2 Inhibitors. Inventors: Chakraborti, A. K. Banerjee, U. C., Kumar, R., Garg, S. K., Meena, V. S., Indian patent, application no. 638/DEL/2008 filed on 14th March 2008. 3. Title: Inhibitors of Phosphodiesterase Type-IV: Benzimidazolone series. Inventors: Chakraborti, A. K. Sarin, S., Rudrawar, S., Kumar, R., Chankeshwara, S. V., Dastidar, S., Ray, A. European patent, application no. 08151539.7-2117, filed on 15th February 2008. US patent, application no. 12/031842, filed on 15th February 2008, United States Patent 20080207659 4. Title: Phosphodiesterase-4 Inhibitors: Urea, Carbamate and Amide series. Inventors: Chakraborti, A. K. Sarin, S., Rudrawar, S., Kumar, R., Chankeshwara, S. V., Dastidar, S., Ray, A. Indian patent, application no. 565/DEL/2006, filed on 3rd March 2006. Research Highlights

ANTICANCER RESARCH

IMINES AND AMIDES AS TOPOISOMERASE II INHIBITORS

Kumar et al. Bioorganic & Medicinal Chemistry 23 (2015) 5654–5661

Kumar et al. Bioorganic & Medicinal Chemistry 21 (2013), 5782-5793

Epidermal Growth Factor Receptor (EGFR) Inhibitors

Kumar et al. Bioorganic Chemistry 58 (2015), 1-10 N-acetylpyrazolines as Anticancer Agents Acting through Intracellular ROS Scavenging and the Mitochondria‐Dependent Death Pathway

Kumar et al. Archiv der Pharmazie, 2014, 347, 1–11

APE-1/Ref Inhibitors

Kumar et al. Journal of Medicinal Chemistry, 57 (24), 10241-10256

Toxicophore exploration as a screening technology for drug design and discovery

Kumar et al. Archives of toxicology, 2015, 1-18

Growth factors mediated cell signalling in prostate cancer

Kumar et al. Chemico-Biological Interactions 240 (2015) 120-133

Xanthine oxidase Inhibitors

5,6-Dihydropyrazolo/pyrazolo[1,5-c]quinazolineDerivatives Phe1009

R1 R1 R1 A Phe914 Leu1014 O Lys771 Glu802 N N N N R HN R B R O R2 O R2 N R2 H Asn768 Thr803 5; R2 = H N-(1,3-Diaryl-3-oxopropyl)amides (3) N-Acetyl pyrazolines (4) 6; R2 = any alkyl or aryl group

Kumar et al. Bioorganic Chemistry 57 (2014) 57–64

N-(1,3-diaryl-3-oxopropyl)amides as xanthine oxidase inhibitors

Kumar et al. Bioorganic & Medicinal Chemistry 19 (2011) 5569–5576

1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as potential non-purine xanthine oxidase inhibitors

Kumar et al. Bioorganic & Medicinal Chemistry 19 (2011) 1950–1958