DOCSLIB.ORG

ABSTRACTS Platform 1

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
ABSTRACTS Platform 1 ABSTRACTS Platform 1 RNA Expression Identifying Ischemic Stroke In Acute Hospital Setting: Interim Analysis From BASE Clinical Trial Daniel J Miller, MD1 1Department of Neurology, Henry Ford Hospital, Detroit, Michigan, United States of America Introduction: Blood testing panels in the acute setting to determine (i) if a stroke occurred, (ii) differentiation cause between cardioembolic stroke (CES) or large artery atherosclerosis stroke (LAA), and (iii) separately detect the presence of atrial fibrillation (AF) would be of significant clinical utility. Using the Biomarkers of Acute Stroke Etiology (BASE) trial (NCT02014896) dataset, our purpose was to utilize blood gene expression signatures as a panel approach for accurately identifying if a stroke occurred compared to a control subject, differentiating LAS from CES acute stroke etiologies, and separately identify AF. Methods: The BASE trial enrolled suspected stroke patients presenting to 20 hospitals within 24 hrs of symptom onset and age, race, gender, smoking, comorbidity match controls. Final gold standard diagnosis and stroke etiology were determined by an adjudication committee using all hospital data but blinded to RNA test results. Whole blood, obtained in PAX tubes, was frozen at -20C within 72 hrs and analyzed at a core lab (Ischemia Care, Dayton, OH) using Affymetrix HTA microarrays. Genes on the HTA microarray were filtered to eliminate genes with low expression or high CV (> 10%) when run on replicate samples leaving 9,513 potential signature genes. A two-way random forest classifier was built through cross validation of the training data resulting in three distinct diagnostic signatures based upon 23 genes for a panel of three separate tests. Results: This is a planned interim cohort study of the 1700 patients enrolled in the BASE trial that does not include lacunar strokes, cryptogenic strokes, TIA, or stroke mimics. Overall, 224 patients were enrolled with NIHSS>=5, 59 (26%) with LAS, 165 (74%) with CES, and 66 control subjects; 56% were male, and median (IQR) age was 72.9 yrs (63.7, 82.9). Median (IQR) time from symptom onset to blood collection was 487 (321, 1129) minutes. Coexistent pathology at presentation included atrial fibrillation 120 (54%), hypertension 186 (83%), hyperlipidemia 186 (48%), diabetes 74 (33%), and coronary artery disease 78 (35%). Patients were randomly divided into training (132) and validation (92). The diagnostic 12 gene signature results distinguished stroke from control; C-statistic 0.86, sensitivity of 0.91, specificity of .61. The diagnostic 3 gene signature results distinguished CES from LAA C-statistic 0.70, sensitivity of 0.85, specificity of 0.49. The diagnostic 8 gene signature results distinguished AF from (a) cardioembolic stroke not due to atrial fibrillation and (b) LAA, C-statistic 0.69, sensitivity of 0.70, specificity of 0.59. Conclusions: Targeted panels of RNA expression markers may be used together or separately to determine if a stroke occurred, stratification into CE and LAA causes, and presence of AF, and may have triage, interventional, therapeutic, and secondary prevention implications. Keywords: Acute Stroke, Ischemic Stroke, Acute Ischemic Stroke Intervention, New Innovation, Inflammation Financial Disclosures: The authors had no disclosures. Grant Support: None. Platform 2 Closely Sizing the Catheter to Vessel Enables Flow-Arrest and Flow-Reversal During Aspiration in the MCA Raul G Nogueira, Professor1, David Ryan, Mr2, Liam Mullins, PhD3, John Thornton, FFR RCSI4, Sean G Fitzgerald, PhD2 1Grady Memorial Hospital and Emory University, Atlanta, Georgia, United States of America; 2National University of Ireland Galway, Galway, Ireland; 3Perfuze Ltd, Galway, Ireland; 4Beaumont Hospital, Dublin, Ireland Introduction: Delgado Almandoz et al. established catheter size as an independent predictor of successful revascularization (mTICI 2b/3) when using A Direct Aspiration First-Pass Thrombectomy (ADAPT) technique1. Several studies have also demonstrated a trend towards higher rates of successful reperfusion with larger bore catheters and with larger catheter-to-vessel diameter ratio,2, 3. While Balloon Guide Catheters (BGCs) are used to achieve flow control and larger bore catheters are known to increase aspiration force, little is known about distal flow a patterns during aspiration. Our objective was to establish flow patterns in terms of distal flow control using various aspiration catheter sizes, with and without the use of BGCs, in a representative in-vitro Circle of Willis model. Methods: The in-vitro model comprised a peristaltic pump, aortic arch and Circle of Willis (Vascular Simulations Inc). Pulse rate (72BPM), flow rate (720mL/min), and temperature (37°C) were controlled to replicate in- vivo conditions. Flow was measured continuously in the distal middle cerebral artery (MCA), 15cm distal to the catheter tip placed in the MCA-M1, using ultrasonic flow sensors (SONOFLOW CO.55/060, SONOTEC GmbH). Four aspiration catheters with increasing lumen size were evaluated; ACE 060 & ACE 064 (Penumbra), Sofia Plus (Microvention) and Millipede 088 (Perfuze). Results: Flow Control: The Millipede 088 device results in a significantly larger reduction in MCA flow than all other aspiration catheters, even when they used with a BGC (Fig 1A). The use of a BGC leads to moderate reduction in the amount of flow in the MCA using the ACE 060, ACE 064 and Sofia Plus devices (Fig 1A). Aspiration: Smaller catheters (ACE 060, ACE 064 and Sofia Plus) were unable to cause flow reversal in the distal MCA during aspiration (Fig 1 B&C). This means that there is still forward flow in the distal MCA during aspiration. Millipede 088 achieved complete flow reversal (-150ml/min) in the distal MCA during aspiration (Fig 1 D). Conclusions: Two key behaviours were observed. First, closely matching the catheter size to the vessel size allows the physician to control the degree of local flow arrest upon catheter insertion potentially negating the need for a BGC. Second, an 088 ID catheter enables significant flow reversal in the distal MCA during aspiration meaning that fluid is drawn from distal regions (distal aspiration) of the vasculature potentially enabling removal of distal clot emboli. Keywords: Endovascular, New Technique, Balloon Guide Catheter, Neurointerventional Education, Financial Disclosures: Perfuze Ltd - Stock Holder Grant Support: This work was supported by the European Regional Development Enterprise Ireland grant number IP-2019-0865. Platform 3 Long-term sided branch and perforator patency following Surpass flow diverter treatment in the SCENT Trial Miklos Marosfoi, MD1, Joost de Vries, MD2, Peter T Kan, MD3, Ricardo A Hanel, MD4, Alexander L Coon, MD5, Philip M Meyers, MD6, Ajay K Wakhloo, MD1 1Department of Neurointerventional Radiology, Beth Israel Lahey Health, LHMC, Burlington, Massachusetts, United States of America; 2Department of Neurosurgery, Radboud University Medical Center, Nijmegen, Netherlands; 3Department of Neurosurgery Baylor College of Medicine, Houston, Texas, United States of America; 4Department of Neurosurgery, Jacksonville Baptist, Jacksonville, Florida, United States of America; 5Carondelet Neurological Institute, St. Joseph's Hospital, Tucson, Arizona, United States of America; 6Department of Neurosurgery Columbia University Medical Center, New York, New York, United States of America Introduction: Flow diverters (FD) have demonstrated to be highly effective in the treatment of intracranial aneurysms (IA). Multiple international studies have reported long-term occlusion rates between 85% and 95%. When treating IA, FD frequently does cover side branches or perforators. The fate of these covered vessels has not systematically been evaluated. We did a post-hoc data analysis of the SCENT trial and studied the long-term patency of these vessels and correlated it with clinical outcome. Methods: Subjects enrolled in the SCENT Trial with at least a 1-year angiographic follow-up were included. Patency of covered ophthalmic (OphA), anterior choroidal (AChA) and lenticulostriate arteries (LSA) were retrospectively analyzed on angiograms by two independent experienced neurointerventionalists. Images were available at the time of the procedure, at 6 months and at 1, 3, and 5 years. Flow within the side branches and perforators were scored as brisk, slow or absent. The artery was considered occluded if not discerned on follow-up imaging. Occlusions were classified as symptomatic or asymptomatic and changes in vessel patency over multiple follow-up angiographic studies were recorded. Results: A total of 171 subjects out of 180 enrolled in the Surpass SCENT trial with ICA aneurysms treated were available for assessment. Six-hundred fifteen angiograms were reviewed and scored. Follow-up angiography was available for: 153/171 (89.4%) of the patients at 1 year; 109/171 (63.7%) patients at 3 years; 29/171 (17.0%) patients at 5 years. In total 225 side branches or perforators were covered. OphA, AChA, and LSA were covered in 143 (84%), 63 (37%), and 19 (11%) of the subjects respectively. Ophthalmic arteries were patent at one year in 119/127 (93%) patients and the number of the compromised vessels remained the same at 3 years. One 1/51 (2%) AchA progressed to an occlusion at 3 years; one AchA with a slow flow - did not change over time. There were no LSA (0/19) occlusions at 1 and 3 years. From a total of 225 covered vessels, 7 (3.1%) were symptomatic, and were associated with the OphA [7/127 (5.5%)]; there
Load more

Recommended publications
  • Mygland, Aali, Matre, Gilhus Spine, and One of Us (Lhermitte) Published
    846 Mygland, Aali, Matre, Gilhus 14 Gautel M, Lakey A, Barlow DP, et al. Titin antibodies in 18 Mantegazza R, Beghi E, Pareyson D, et al. A multicentre myasthenia gravis: Identification of a major autogenic follow up study of 1152 patients with myasthenia gravis J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.57.7.846 on 1 July 1994. Downloaded from region of titin. Neurology 1994 (in press). in Italy. J Neurol 1990;237:339-44. 15 Grob D, Arsura EL, Brunner NG, Namba T. The course 19 Pagala MKD, Nandakumar NV, Venkatachari SAT, of myasthenia gravis and therapies affecting outcome. Ravindran K, Namba T, Grob D. Responses of inter- Ann NYAcad Sci 1987;505:472-99. costal muscle biopsies from normal subjects and 16 Oosterhuis HJGH. The natural course of mysthenia patients with myasthenia gravis. Muscle Nerve 1990;13: gravis: a long term follow up study. .J Neurol Neurosurg 1012-22. Psychiariy 1989;52:1 121-7. 20 Nielson VK, Paulson OB, Rosenkvist J, Holsoe E, Lefvert 17 Durelli L, Maggi G, Casadio C, Ferri R, Rendine S, AK. Rapid improvement of myasthenia gravis after Bergamini L. Actuarial analysis of the occurrence of plasma exchange. Ann Neurol 1982;11: 160-9. remissions following thymectomy for myasthenia gravis 21 Namba T, Brunner NG, Grob D. Idiopathic giant cell in 400 patients. Jf Neurol Neurosurg Psychiatry 1994;54: polymyositis: report of a case and review of the syn- 406-11. drome. Arch Neurol 1974;31:27-30. Jean Lhermitte 1877-1959 He showed the importance of the inferior olivary nucleus in myoclonus.
    [Show full text]
  • How to Improve the Management of Acute Ischemic Stroke by Modern Technologies, Artificial Intelligence, and New Treatment Methods
    life Review How to Improve the Management of Acute Ischemic Stroke by Modern Technologies, Artificial Intelligence, and New Treatment Methods Kamil Zele ˇnák 1,2,* , Antonín Krajina 3, Lukas Meyer 4, Jens Fiehler 4, ESMINT Artificial Intelligence and Robotics Ad hoc Committee 2, Daniel Behme 2,5, Deniz Bulja 2,6, Jildaz Caroff 2,7 , Amar Ajay Chotai 2,8 , Valerio Da Ros 2,9 , Jean-Christophe Gentric 2,10, Jeremy Hofmeister 2,11, Omar Kass-Hout 2,12 , Özcan Kocatürk 2,13, Jeremy Lynch 2,14, Ernesto Pearson 2,15 and Ivan Vukasinovic 2,16 1 Clinic of Radiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03659 Martin, Slovakia 2 ESMINT Artificial Intelligence and Robotics Ad hoc Committee, ESMINT, 8008 Zurich, Switzerland; offi[email protected] (E.A.I.R.A.h.C.); [email protected] (D.B.); [email protected] (D.B.); [email protected] (J.C.); [email protected] (A.A.C.); [email protected] (V.D.R.); [email protected] (J.-C.G.); [email protected] (J.H.); [email protected] (O.K.-H.); [email protected] (Ö.K.); [email protected] (J.L.); [email protected] (E.P.); [email protected] (I.V.) 3 Citation: Zeleˇnák,K.; Krajina, A.; Department of Radiology, Charles University Faculty of Medicine and University Hospital, CZ-500 05 Hradec Králové, Czech Republic; [email protected] Meyer, L.; Fiehler, J.; ESMINT 4 Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Artificial Intelligence and Robotics 20251 Hamburg, Germany; [email protected] (L.M.); fi[email protected] (J.F.) Ad hoc Committee; Behme, D.; Bulja, 5 University Clinic for Neuroradiology, Medical Faculty, Otto-von-Guericke University Magdeburg, D.; Caroff, J.; Chotai, A.A.; Da Ros, V.; 39120 Magdeburg, Germany et al.
    [Show full text]
  • Kentucky Derby, Flamingo Stakes, Florida Derby, Blue Grass Stakes, Preakness, Queen’S Plate 3RD Belmont Stakes
    Northern Dancer 90th May 2, 1964 THE WINNER’S PEDIGREE AND CAREER HIGHLIGHTS Pharos Nearco Nogara Nearctic *Lady Angela Hyperion NORTHERN DANCER Sister Sarah Polynesian Bay Colt Native Dancer Geisha Natalma Almahmoud *Mahmoud Arbitrator YEAR AGE STS. 1ST 2ND 3RD EARNINGS 1963 2 9 7 2 0 $ 90,635 1964 3 9 7 0 2 $490,012 TOTALS 18 14 2 2 $580,647 At 2 Years WON Summer Stakes, Coronation Futurity, Carleton Stakes, Remsen Stakes 2ND Vandal Stakes, Cup and Saucer Stakes At 3 Years WON Kentucky Derby, Flamingo Stakes, Florida Derby, Blue Grass Stakes, Preakness, Queen’s Plate 3RD Belmont Stakes Horse Eq. Wt. PP 1/4 1/2 3/4 MILE STR. FIN. Jockey Owner Odds To $1 Northern Dancer b 126 7 7 2-1/2 6 hd 6 2 1 hd 1 2 1 nk W. Hartack Windfields Farm 3.40 Hill Rise 126 11 6 1-1/2 7 2-1/2 8 hd 4 hd 2 1-1/2 2 3-1/4 W. Shoemaker El Peco Ranch 1.40 The Scoundrel b 126 6 3 1/2 4 hd 3 1 2 1 3 2 3 no M. Ycaza R. C. Ellsworth 6.00 Roman Brother 126 12 9 2 9 1/2 9 2 6 2 4 1/2 4 nk W. Chambers Harbor View Farm 30.60 Quadrangle b 126 2 5 1 5 1-1/2 4 hd 5 1-1/2 5 1 5 3 R. Ussery Rokeby Stables 5.30 Mr. Brick 126 1 2 3 1 1/2 1 1/2 3 1 6 3 6 3/4 I.
    [Show full text]
  • Demonic Possession by Jean Lhermitte
    G Model ENCEP-991; No. of Pages 5 ARTICLE IN PRESS L’Encéphale xxx (2017) xxx–xxx Disponible en ligne sur ScienceDirect www.sciencedirect.com Commentary Demonic possession by Jean Lhermitte Possession diabolique par Jean Lhermitte a b c,∗ E. Drouin , T. Péréon , Y. Péréon a Centre des hautes études de la Renaissance, université de Tours, 37000 Tours, France b Pôle hospitalo-universitaire de psychiatrie adulte, centre hospitalier Guillaume-Régnier, 35703 Rennes, France c Centre de référence maladies neuromusculaires Nantes–Angers, laboratoire d’explorations fonctionnelles, Hôtel-Dieu, CHU de Nantes, 44093 Nantes cedex, France a r t i c l e i n f o a b s t r a c t Article history: The name of the French neurologist and psychiatrist Jean Lhermitte (1877–1959) is most often associ- Received 13 September 2016 ated with the sign he described back in 1927 in three patients with multiple sclerosis. We are reporting Accepted 13 March 2017 unpublished handwritten notes by Jean Lhermitte about ‘demonic possession’, which date from the 1950s. Available online xxx Drawing from his experiences in neuropsychiatry, Lhermitte gathered notable case reviews as well as individual case histories. For him, cases of demonic possession are of a psychiatric nature with social back- Keywords: ground exerting a strong influence. Like Freud did earlier, Lhermitte believes that the majority of those Demonopathy possessed people have been subjected to sexual trauma with scruples, often linked to religion. Demonic Handwritten notes possession cases were not so rare in the 1950s but their number has nowadays declined substantially with the development of modern psychiatry.
    [Show full text]
  • Joseph Jumentié 1879-1928
    Joseph Jumentié 1879-1928 Olivier Walusinski Médecin de famille 28160 Brou [email protected] Fig. 1. Joseph Jumentié à La Salpêtrière en 1910 (BIUsanté Paris, domaine public). Résumé Joseph Jumentié (1879-1928), par ses qualités de clinicien et sa sagacité d’anatomo- pathologiste, sut faire honneur à ses maîtres en neurologie, Jules Dejerine, Augusta Dejerine- Klumpke et Joseph Babiński. Leur notoriété a laissé dans l’ombre la collaboration précieuse que Jumentié leur a assurée. A côté d’une remarquable thèse de doctorat fixant la sémiologie des tumeurs de l’angle ponto-cérébelleux en 1911, ses nombreuses publications ont abordé tous les domaines de la neurologie. Nous présentons, à titre d’exemple, ses recherches concernant le cervelet, les tumeurs cérébrales et mettons en valeur l’aide fournie à Mme Dejerine dans l’identification des « faisceaux » des grandes voies cortico-spinales au niveau bulbo- protubérantiel par la technique des coupes sériées multiples. Cette évocation est précédée d’une brève biographie illustrée de photos, pour la plupart, inédites. 1 Jules Dejerine (1849-1917) et Joseph Babiński (1857-1932) sont des neurologues célèbres et reconnus mondialement. Leurs travaux n’auraient sans doute pas toute la valeur que nous leur accordons, s’ils n’avaient pas eu l’aide déterminante de collaborateurs compétents et zélés. Joseph Jumentié est l’un de ceux-ci, formé par ces deux maîtres de la neurologie auxquels il resta fidèlement très attaché. Leur célébrité, comme une ombre portée, a plongé dans l’oubli l’œuvre de Jumentié. C’est celle-ci que nous souhaitons remettre en lumière. Joseph Julien Jumentié est né le 28 octobre 1879 à Clermont-Ferrand d’un père Alfred Jumentié (1848-1909) professeur au lycée et d’une mère au foyer Mathilde Poisson (1852-1902).
    [Show full text]
  • Shereif Hassan Mahmoud
    Hydroclimate Changes to Arid regions subjected to Impact of climate change, human activities, and Large-scale climate patterns by Shereif Hassan Mahmoud A thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Water Resources Engineering Department of Civil and Environmental Engineering University of Alberta © Shereif Hassan Mahmoud, 2020 Abstract In recent years, many regions worldwide have suffered from natural hazards related to the impact of human activities and climate change, such as floods and droughts, sea level rise, extreme weather events and an accelerated hydrological cycle. In Africa, the driest continent on Earth, climate change has led to more frequent occurrences of droughts of greater severity. Beside climate change, human activities have also incurred negative environmental impact which in turn has likely affected the climate at a wide range of temporal-spatial scales worldwide. For example, in the Middle East, floods of greater magnitude have been occurring more frequently in recent decades, which could be attributed partly to rapid urbanization or the effect of climate change, or both. In the Nile River basin (NRB), recurring droughts and increasing population have led to rising tension between competing users for water. Therefore, to develop more effective mitigation strategies against the potential impact of climate change, there is an urgent need to better understand changes to the hydrologic cycle of arid regions and linkage to regional climate change. The objectives of this dissertation are: 1) To investigate the potential implications of urbanization and climate change to the flood risk of Egypt and Saudi Arabia of arid climate in the Middle East.
    [Show full text]
  • Mahmoud Saïd by Valérie Hess 74 Essay
    Essay 73 Mahmoud Saïd By Valérie Hess 74 Essay Introduction referenced in art history courses in Western universities. For most art historians, the Bénézit dictionary, Nada Shabout’s lectures and seminars at the University initiated by Emmanuel Bénézit (1854-1920) in 1911, of North Texas are probably the most relevant to Saïd in is recognised as being probably the most important terms of subject and historical context. In other words, it and comprehensive reference dictionary for painters, seems that Mahmoud Saïd’s name, as most of his fellow sculptors, draughtsmen and engravers from all across Modern Egyptian artists, has simply been omitted from the world. Its full title in French is translated as ‘Critical the Western concept of the History of Art. and documentary dictionary of painters, sculptors, Paradoxically, several books and thesis written by locally draughtsmen and engravers from all times and from and internationally acclaimed academics, from Aimé all countries by a group of French and foreign expert Azar in 1961 to Esmat Dawastashy in 1997, from writers’ in the 1999 fourth edition published in fourteen Liliane Karnouk in 2005 to Nesma Atallah in 2010, volumes. This encyclopaedia of artists consists of 13,440 have rightfully identified Mahmoud Saïd as one of the pages for 175,000 names, yet nowhere does the name main pioneers of Modern Egyptian Art and arguably the ‘Mahmoud Saïd’ feature. The entries under the ‘SAI’ father of Modern Egyptian Painting. It therefore comes section are alphabetically listed as such: SAIA, Pietro with no surprise that one of the jewels of Alexandria, (1779-1833); SAÏD (See also LÉVY Alphonse Jacques); the artist’s native city, is a museum entirely dedicated to SAÏD, Anne (1914-1995); SAIDI, Aboul Ghasem (b.
    [Show full text]
  • Lady Eli Retired, to Be Bred to War Front
    WEDNESDAY, JANUARY 17, 2018 LADY ELI RETIRED, TO BE BREEDERS= CUP EYES FUTURE HOST SITES, POSSIBLE NEW RACE by Perry Lefko BRED TO WAR FRONT The Board of the Breeders' Cup World Championships will meet later this month to talk about tracks that could potentially host the event from 2019-22 and also discuss the possibility of adding another race. Fred Hertrich III, voted in as the Breeders' Cup Chairman last September, told the TDN that six tracks have expressed tentative interest in hosting the event after this year's Breeders' Cup World Championships at Churchill Downs, November 2-3. All six have been sent letters of tentative interest. Hertrich said when the Breeders' Cup Ltd. hears back from the tracks, it will send out contracts outlining all the details, dates and demands to be considered and see how many respond. Cont. p5 Lady Eli & Irad Ortiz, Jr. | Sarah K Andrew IN TDN EUROPE TODAY by Bill Finley After considering the possibility of racing their star mare this AN ENDURING DREAM FOR CHEVELEY PARK STUD year, co-owners Jay Hanley and Sol Kumin, partners in the Sheep Emma Berry speaks with Chris Richardson regarding Pond Partners stable, have decided to retire Lady Eli (Divine Cheveley Park Stud’s new stallion acquisition Ulysses (Ire) Park--Sacre Coeur, by Saint Ballado). She will be bred to War (Galileo {Ire}). Click or tap here to go straight to TDN Europe. Front and then sold at the 2018 Keeneland November Breeding Stock sale as part John Sikura=s Hill >n= Dale consignment. Following a seventh-place finish in the GI Breeders= Cup Filly & Mare Turf, Lady Eli was entered in the 2017 Keeneland sale, but had to be withdrawn when coming out of the race with lacerations and a puncture wound, which required rest and treatment.
    [Show full text]
  • Sunday, March 1, 2020 Today in the Tdn Ete Indien All The
    SUNDAY, MARCH 1, 2020 TODAY IN THE TDN ETE INDIEN ALL THE WAY IN FOUNTAIN OF YOUTH MR FREEZE DOMINATES GULFSTREAM PARK MILE TONALIST=S SHAPE STILL PERFECT AFTER DAVONA DALE PEGASUS TURF WINNER ADDS TO BANKROLL BODEMEISTER FILLY STEALS ANOTHER ONE AT GP IN TDN EUROPE SPEIGHTSTOWN=S FULL FLAT TAKES THE SAUDI DERBY FRANKEL EXACTA IN THE LONGINES TURF CUP ATTENDANCE RESTRICTED AT THREE FRENCH MEETINGS Click or tap here to go straight to TDN Europe/International PUBLISHER & CEO Sue Morris Finley @suefinley [email protected] SENIOR VICE PRESIDENT Gary King @garykingTDN [email protected] EDITORIAL [email protected] Editor-in-Chief Jessica Martini @JessMartiniTDN Managing Editor Sunday, March 1, 2020 Alan Carasso @EquinealTDN Senior Editor Steve Sherack @SteveSherackTDN Racing Editor Brian DiDonato @BDiDonatoTDN Deputy Editor Christie DeBernardis @CDeBernardisTDN Associate Editors Christina Bossinakis @CBossTDN Joe Bianca @JBiancaTDN News and Features Editor In Memoriam: Ben Massam (1988-2019) ADVERTISING [email protected] Director of Advertising Alycia Borer Advertising Manager Lia Best Advertising Designer Amanda Crelin Advertising Assistant/Dir. Of Distribution Rachel McCaffrey Advertising Assistants Amie Newcomb Saudi Cup coverage continues on page 3. | Jockey Club of Saudi Arabia/Mahmoud Khaled Kristen Lomasson Photographer/Photo Editor 70 HOURS IN RIYADH Sarah K. Andrew @SarahKAndrew 5 [email protected] Editor-in-Chief Jessica Martini shares her impressions of Saudi Arabia and King Abdulaziz racetrack. Social Media Strategist Justina Severni Director of Customer Service Vicki Forbes ETE INDIEN GOES GATE TO WIRE IN FOY 9 [email protected] Patrick Biancone trainee Ete Indien (Summer Front) rushed to the front from his wide draw and never Marketing Manager looked back to take Saturday’s GII Fasig-Tipton Fountain Alayna Cullen @AlaynaCullen of Youth S.
    [Show full text]
  • BUTTERS FAMILY There Were 4 Brothers Who Attended
    BUTTERS FAMILY There were 4 brothers who attended Framlingham between 1888 and 1905 and a couple of them were very prominent racehorse trainers. JOSEPH ARTHUR “FRANK” BUTTERS (1888-95) Frank Butters was Champion Trainer 8 times between 1927 and 1949. In addition to training the winners of 15 Classics in England he also trained Irish Derby winners Turkhan, Nathoo and Hindostan and Prix de L'Arc de Triomphe winner Migoli for the Aga Khan III. Frank Butters was born in Austria, where his father Joseph rode and trained, and became a successful trainer there himself. During the 1914-18 war he was nominally interned, then trained in Italy before being given a 4 year contract as private trainer to the 17th Earl of Derby at Stanley House, Newmarket, becoming leading trainer in his first year there, 1927. When Lord Derby withdrew from racing for economic reasons, Butters leased the Fitzroy Stables in Newmarket as a public trainer. Here he trained for Mr A W Gordon and, later, the Aga Khan III and the 5th Earl of Durham. He considered Bahram to be the best horse he ever trained. Important successes: 2000 Guineas 1000 Guineas Derby Bahram 1935 (T) Fair Isle 1930 (T) Bahram 1935 (T) Mahmoud 1936 (T) Oaks St Leger Other major race(s) Beam 1927 (T) Fairway 1928 (T) (featuring horses in this database) Toboggan 1928 (T) Firdaussi 1932 (T) Princess of Wales's Stakes Colorado 1927 (T) Udaipur 1932 (T) Bahram 1935 (T) Eclipse Stakes Colorado 1927 (T) Light Brocade 1934 (T) Turkhan 1940 (T) Eclipse Stakes Fairway 1928 (T) Steady Aim 1946 (T) Tehran 1944 (T) Champion Stakes Fairway 1928 (T) Masaka 1948 (T) Champion Stakes Fairway 1929 (T) Champion Stakes Umidwar 1934 (T) Jockey Club Stakes Umidwar 1934 (T) Dewhurst Stakes, Newmarket Bala Hissar 1935 (T) LTCOLONEL JAMES WAUGH BUTTERS OBE (1889-1904) Unlike Frank, he doesn’t appear to have been involved at all in horse racing.
    [Show full text]
  • MISTIC Collaborative Stroke Update
    MISTIC Collaborative Stroke Update Friday, April 30, 2021 12 p.m. – 4 p.m. and Saturday, May 1, 2021 8 a.m. – 12 p.m. Virtual Presentation via Zoom According to the Centers of Disease Control and Prevention, stroke afflicts nearly 800,000 people and causes approximately 130,000 deaths in the US each year. Stroke is also the leading cause of long-term disability and costs our nation billions in treatment dollars on an annual basis, which causes significant challenges for physicians and allied healthcare professionals. Through the use of lectures and case discussion, national and regional experts will address the latest advances in pre-hospital stroke care, treatment of intracranial aneurysms, extracranial and intracranial atherosclerotic disease and techniques of mechanical thrombectomy. The purpose of this conference is to provide neurosurgeons, neurologists, family medicine, internal medicine, trauma and emergency room physicians, residents, advanced practice providers, nurses, pharmacists, radiology techs, and other healthcare professionals with advances in stroke care. The MISTIC Mission: The MIchigan Stroke Treatment Improvement Collaborative (MISTIC) is a multi-institutional effort led by cerebrovascular specialists across greater Michigan and northwest Ohio areas to improve stroke care, advance clinical research, and train the next generation of clinicians. Participating Institutions: Michigan Medicine, ProMedica, University of Toledo, Ascension St. John/Providence Park, Ascension St. Mary’s Saginaw, Beaumont Royal Oak, DMC, Henry Ford Hospital, McLaren Flint/Macomb, Metro Health, Munson Medical Center, Sparrow, Spectrum, St. Vincent Mercy Presented by ProMedica’s Continuing Medical Education Department Faculty Joseph Adel, MD, FAANS Cerebrovascular, Endovascular & Skull Base Neurosurgery Clinical Associate Professor, Central Michigan University Ascension St.
    [Show full text]
  • The Interface of Religious and Political Conflict in Egyptian Theatre
    The Interface of Religious and Political Conflict in Egyptian Theatre Dissertation Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Amany Youssef Seleem, Stage Directing Diploma Graduate Program in Theatre The Ohio State University 2013 Dissertation Committee: Lesley Ferris, Advisor Nena Couch Beth Kattelman Copyright by Amany Seleem 2013 Abstract Using religion to achieve political power is a thematic subject used by a number of Egyptian playwrights. This dissertation documents and analyzes eleven plays by five prominent Egyptian playwrights: Tawfiq Al-Hakim (1898- 1987), Ali Ahmed Bakathir (1910- 1969), Samir Sarhan (1938- 2006), Mohamed Abul Ela Al-Salamouni (1941- ), and Mohamed Salmawi (1945- ). Through their plays they call attention to the dangers of blind obedience. The primary methodological approach will be a close literary analysis grounded in historical considerations underscored by a chronology of Egyptian leadership. Thus the interface of religious conflict and politics is linked to the four heads of government under which the playwrights wrote their works: the eras of King Farouk I (1920-1965), President Gamal Abdel Nasser (1918-1970), President Anwar Sadat (1918-1981), and President Hosni Mubarak (1928- ). While this study ends with Mubarak’s regime, it briefly considers the way in which such conflict ended in the recent reunion between religion and politics with the election of Mohamed Morsi, a member of the Muslim Brotherhood, as president following the Egyptian Revolution of 2011. This research also investigates how these scripts were written— particularly in terms of their adaptation from existing canonical work or historical events and the use of metaphor—and how they were staged.
    [Show full text]