Supplementary Table S2. Annotations of differentially expressed probe sets to the KEGG pathways using the EASE software. Signaling pathways containing the highest numbers of are included. Multiple fold changes indicate that multiple probe sets correspond to one on the microarray.

Pathway Fold change Gene 2.6 Csf1; colony stimulating factor 1 (macrophage) -2.6 Ghr; growth 4.9, 4.8, 3.1 Cytokine- Hgf; hepatocyte growth factor (hepapoietin A; scatter factor) -2.6 cytokine Ifnar2; (alpha, beta and omega) receptor 2 -2.1 receptor Il18; interleukin 18 (interferon-gamma-inducing factor) 2.2 interaction Ltbr; lymphotoxin beta receptor (TNFR superfamily, member 3) 5.3, 4.6 Tnfrsf12a; tumor necrosis factor receptor superfamily, member 12A -10.6, -10.8 Cxcl12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) -6.4 Tgfb2; transforming growth factor, beta 2

3.3 Ctnnb1; catenin (cadherin-associated ), beta 1, 88kDa 2.7 Akt1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) -3.4, -3.4 Figf; c-fos induced growth factor 4.9, 4.8, 3.1 Hgf; hepatocyte growth factor Focal adhesion -10.5, -16.5 Igf1; insulin-like growth factor 1 -14.7 Lama4; laminin, alpha 4 5.1, 3.5, 2.4 Actb; actin, beta 8.1 Rock1; Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.1.37) 18.7, 11.4, 3.0 Thbs1; thrombospondin 1

1.9 Cfl2; cofilin 2 2.9 Efnb2; ephrin-B2 1.9 Epha4; EPH receptor A4 (EC:2.7.10.1) Axon guidance -9.9 Ablim1; actin binding LIM protein 1 8.1 Rock1; Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.1.37) -10.6, -10.8 Cxcl12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 3.5, 2.7 Sema5a; semaphorin 5A

2.7 Akt1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) 3.9 Fgf7; fibroblast growth factor 7 MAPK signaling 8.9, 2.2, 2.0 Mef2c; myocyte enhancer factor 2C pathway 2.8 Gadd45b; growth arrest and DNA-damage-inducible, beta 2 Ppm1b; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform (EC:3.1.3.16) -6.4 Tgfb2; transforming growth factor, beta 2

2.9 Csnk2a1; casein kinase 2, alpha 1 polypeptide (EC:2.7.11.1) 3.3 Ctnnb1; catenin (cadherin-associated protein), beta 1, 88kDa 2.7 Tight junction Akt1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) 5.1, 3.5, 2.4 Actb; actin, beta 2.8 Csda; cold shock domain protein A 3.7 Tjp2; tight junction protein 2

3.3 Ctnnb1; catenin (cadherin-associated protein), beta 1, 88kDa 2.9, 2.8, 2.6 Leukocyte Cd99; CD99 molecule -2.8, -6.8 transendothelial Mmp9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) 5.1, 3.5, 2.4 migration Actb; actin, beta 8.1 Rock1; Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.1.37) -10.6, -10.8 Cxcl12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

4.3 Gna13; guanine nucleotide binding protein (G protein), alpha 13 1.9 Regulation of Cfl2; cofilin 2 3.9 actin Fgf7; fibroblast growth factor 7 5.2 cytoskeleton Pfn1; profilin 1 5.1, 3.5, 2.4 Actb; actin, beta 8.1 Rock1; Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.1.37)

2.2 Mdm2; Mdm2 p53 binding protein homolog (mouse) [EC:6.3.2.19] 2.8 Gadd45b; growth arrest and DNA-damage-inducible, beta Cell cycle 2.1 Anapc5; anaphase promoting complex subunit 5 -6.4 Tgfb2; transforming growth factor, beta 2 2.9, 2.6 Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

-10.5, -16.5 Igf1; insulin-like growth factor 1 2.2 p53 signaling Mdm2; Mdm2 p53 binding protein homolog (mouse) [EC:6.3.2.19] 2.8 pathway Gadd45b; growth arrest and DNA-damage-inducible, beta 4.2 Serpine1; serpin peptidase inhibitor, clade E, member 1 18.7, 11.4, 3.0 Thbs1; thrombospondin 1 -3.4 Spry2; sprouty homolog 2 (Drosophila) Jak-STAT 2.7 Akt1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) signaling -2.6 Ghr; pathway -2.6 Ifnar2; interferon (alpha, beta and omega) receptor 2 2.6 Stat2; signal transducer and activator of transcription 2

3.3 Ctnnb1; catenin (cadherin-associated protein), beta 1, 88kDa Pathogenic -2.3 Ly96; lymphocyte antigen 96 Escherichia 5.1, 3.5, 2.4 Actb; actin, beta coli infection 8.1 Rock1; Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.1.37) 2.9, 2.6 Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

2.7 Akt1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) -3.4, -3.4 Renal cell Figf; c-fos induced growth factor 4.9, 4.8, 3.1 carcinoma Hgf; hepatocyte growth factor 2.3 Slc2a1; solute carrier family 2 (facilitated glucose transporter), member 1 -6.4 Tgfb2; transforming growth factor, beta 2

3.3 Ctnnb11; catenin (cadherin-associated protein), beta 1, 88kDa 2.7 Prostate Akt1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) -10.5, -16.5 cancer Igf1; insulin-like growth factor 1 2.2 Mdm2; Mdm2 p53 binding protein homolog (mouse) [EC:6.3.2.19] 2 Srd5a1; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (

2.7 Akt1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) 3.9 Fgf7; fibroblast growth factor 7 Melanoma 4.9, 4.8, 3.1 Hgf; hepatocyte growth factor -10.5, -16.5 Igf1; insulin-like growth factor 1 2.2 Mdm2; Mdm2 p53 binding protein homolog (mouse) [EC:6.3.2.19]