History of vector control in • Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 113(5): e1703981, 2018 1|6 Yanouk Epelboin et al. - Status tibility Resistant Resistant Resistant Resistant Resistant Resistant susceptible susceptible susceptible susceptible susceptible susceptible susceptible susceptible susceptible susceptible susceptible susceptible susceptible susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible loss suscep loss Cayenne Cayenne Cayenne Cayenne Collection site Collection French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana French Guiana Rémire-Montjoly Rémire-Montjoly Rémire-Montjoly Saint Laurent du maroni Saint Laurent du maroni Saint Laurent du maroni Saint Laurent du maroni Saint Laurent du maroni

20 20 20 20 20 20 20 20 20 20 20 NA NA NA NA NA 241 235 197 345 292 240 240 240 240 240 240 Number of mosquitoes tested mosquitoes NA delta DDT DDT DDT DDT DDT HCH HCH HCH tested dieldrin fenthion fenthion fenthion fenthion fenthion Dieldrin Dieldrin Dieldrin Dieldrin malathion malathion malathion malathion malathion malathion Insecticide deltamethrin from 1958 to 2009in from 1958 several localities in French Guiana NA NA NA NA NA Brown Brown Brown Brown Brown Brown Brown Brown Brown Brown Brown Protocol Busvine-Fay Busvine-Fay Busvine-Fay Busvine-Fay Busvine-Fay Busvine-Fay Busvine-Fay Busvine-Fay Busvine-Fay Busvine-Fay Busvine-Fay

TABLE Aedes aegyptiAedes 1959 1959 1959 1959 1959 1958 1958 1958 1958 1958 1958 1963 1963 1965 1965 1965 1965 1965 1965 1965 1965 1965 1965 1965 1972 1995 1996 or date range Collection date Collection NA dult f1 adults adults adults adults adults adults adults adults adults adults adults a adult f0 adult adult f1(gorgee) adult f1(gorgee) adult Mosquitoes tested Mosquitoes Wild caught larvae Wild caught larvae Wild caught larvae Wild caught larvae Wild caught larvae Wild caught larvae Wild caught larvae Wild caught larvae Wild caught larvae Wild caught larvae Wild caught larvae - - -

ciatus ciatus Species darlingi fasciatus aquasalis Anopheles Anopheles Anopheles Ae. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. An. darlingi An. aquasalis An. aquasalis Aedes aegyptiAedes C. quinquefas C. quinquefas Culex quinque Insecticide resistance status based on insecticide testing of

1959)

) 1965a Source the of data Floch and Fauran (1958) Floch and Fauran (1958) Floch and Fauran (1958) Floch and Fauran (1958) Floch and Fauran (1958) Floch and Fauran (1958) Fontan and Fauran (1959) Fontan and Fauran ( Fontan and Fauran (1959) Fontan and Fauran (1959) Fontan and Fauran (1959) Floch (1965a) Floch ( Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Floch et al. (1966) Cebret and Désiré (1996) Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane

SUPPLEMENTARY DATA 2|6 History of vector control in French Guiana • Yanouk Epelboin et al. Status Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Susceptible Susceptible Susceptible Susceptible - -

enne enne Cayenne Collection site Collection zéphir, Cayenne zéphir, Cayenne zéphir, Cayenne Rémire-Montjoly Rémire-Montjoly Rémire-Montjoly Rémire-Montjoly degrad des cannes, Lamirande, Lamirande, Matoury Matoury & Matoury & Sinnamary Matoury & Sinnamary Matoury & Sinnamary Matoury & Sinnamary Matoury & Sinnamary degrad des cannes, Cay degrad des cannes, Cay Saint Laurent du Maroni Cayenne, Rémire-Montjoly, Cayenne, Rémire-Montjoly, Cayenne, Rémire-Montjoly, Cayenne, Rémire-Montjoly, Cayenne, Rémire-Montjoly, Cayenne, Rémire-Montjoly,

97 92 NA NA NA NA NA 196 395 123 100 100 100 800 400 400 1200 1200 1200 Number of mosquitoes tested mosquitoes tested (Baytex) Fenthion Fenthion Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Malathion Malathion Malathion Malathion Insecticide Fenitrothion Fenitrothion Deltamethrin dose dose dose dose dose Protocol diagnostic diagnostic diagnostic diagnostic diagnostic dose unique dose unique dose-response dose-response dose-response dose-response dose-response dose-response dose-response dose-response dose-response dose-response dose-response dose-response

1998 1998 1998 1995 1995 1995 2001 2001 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 or date range Collection date Collection F1 larvae F1 larvae Mosquitoes tested Mosquitoes adults reared from adults reared from adults reared from wild caught larvae wild caught larvae wild caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught Species Ae. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe.

Source the of data Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane

SUPPLEMENTARY DATA Mem Inst Oswaldo Cruz, Rio de Janeiro, 2018 3|6 Status Resistant Resistant Resistant Resistant Resistant Resistant Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible Cacao Régina Matoury Matoury Matoury Matoury Matoury Matoury Cayenne Macouria Collection site Collection Zéphir, Cayenne Rémire-Montjoly Rémire-Montjoly Rémire-Montjoly Rémire-Montjoly Saint Jean du Maroni Saint Laurent du Maroni

75 70 73 50 54 80 NA NA 194 100 100 100 100 100 100 100 100 100 100 Number of mosquitoes tested mosquitoes bti bti tested malathion malathion malathion Temephos Temephos Temephos Insecticide fenitrothion fenitrothion fenitrothion fenitrothion fenitrothion fenitrothion fenitrothion fenitrothion deltamethrin deltamethrin deltamethrin dose dose dose dose dose dose dose dose dose dose dose dose dose dose dose Protocol diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic dose unique dose unique dose-response dose-response

2001 2001 2003 2003 2003 2003 2002 2002 2002 2002 2002 2004 2004 2004 2004 2004 2004 2004 2004 or date range Collection date Collection F1 larvae F1 larvae F1 larvae F2 larvae F1 Adults F1 Adults F1 Adults F1 Adults F1 Adults F1 Adults F1 Adults F1 Adults caught larvae caught larvae caught Adults from wild Adults from wild Mosquitoes tested Mosquitoes wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught Species Ae. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. Source the of data Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane

SUPPLEMENTARY DATA 4|6 History of vector control in French Guiana • Yanouk Epelboin et al. Status Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Susceptible Susceptible Susceptible Susceptible Susceptible Susceptible - Cacao Cacao Régina Régina Kourou Matoury Matoury Matoury Matoury Cayenne Collection site Collection mire-Montjoly Tarzan, Cayenne Tarzan, Rémire-Montjoly Rémire-Montjoly Rémire-Montjoly Cabassou, Cayenne Cabassou, Saint Jean du Maroni Saint Jean du Maroni Saint Jean du Maroni degrad des cannes, Ré

100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 200 200 Number of mosquitoes tested mosquitoes bti bti bti bti bti tested Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Insecticide deltamethrin dose dose dose dose dose dose dose dose dose dose dose dose dose dose Protocol diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic dose unique dose unique dose unique dose unique dose unique

2006 2006 2006 2006 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 or date range Collection date Collection F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 larvae F1 Adults Mosquitoes tested Mosquitoes wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught Species Ae. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. Source the of data Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane

SUPPLEMENTARY DATA Mem Inst Oswaldo Cruz, Rio de Janeiro, 2018 5|6 Status Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Resistant Susceptible Susceptible Susceptible Susceptible - Mana Mana Régina Régina Régina Apatou Apatou Iracoubo Javouhey Collection site Collection mire-Montjoly Tarzan, Cayenne Tarzan, Rémire-Montjoly Rémire-Montjoly Cabassou, Cayenne Cabassou, degrad des cannes, Ré Saint Laurent du Maroni Saint Laurent du Maroni Saint Laurent du Maroni

83 98 95 97 97 NA NA 100 100 100 100 100 100 100 100 100 100 100 100 Number of mosquitoes tested mosquitoes tested Temephos Temephos Temephos Temephos Temephos Temephos Temephos Temephos Insecticide fenitrothion fenitrothion fenitrothion fenitrothion deltamethrin deltamethrin deltamethrin deltamethrin deltamethrin deltamethrin deltamethrin dose dose dose dose dose dose dose dose dose dose dose dose dose dose dose dose dose Protocol diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic dose-response dose-response

2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 or date range Collection date Collection caught larvae caught larvae caught larvae caught larvae caught larvae caught larvae caught larvae caught larvae caught larvae caught larvae caught larvae caught Adults from wild- Adults from wild- Adults from wild- Adults from wild- Adults from wild- Adults from wild- Adults from wild- Adults from wild- Adults from wild- Adults from wild- Adults from wild- Mosquitoes tested Mosquitoes wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught larvae wild-caught Species Ae. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. Source the of data Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane Annual report, ‘Institut Pasteur de la Guyane 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008)

SUPPLEMENTARY DATA 6|6 History of vector control in French Guiana • Yanouk Epelboin et al. Status Resistant Resistant Resistant Resistant Resistant Susceptible Susceptible Kourou Cayenne Iracoubo l’Oyapock l’Oyapock l’Oyapock l’Oyapock Collection site Collection Saint Georges de Saint Georges de Saint Georges de Saint Georges de

45 80 197 100 100 302 208 Number of mosquitoes tested mosquitoes tested Temephos Insecticide fenitrothion fenitrothion deltamethrin deltamethrin deltamethrin deltamethrin dose dose dose dose dose dose dose Protocol diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic diagnostic

2007 2007 2007 2008 2009 2009 2006 or date range Collection date Collection F1 adults F1 adults F1 adults F1 caught larvae caught larvae caught larvae caught Adults from wild- Adults from wild- Adults from wild- Mosquitoes tested Mosquitoes wild-caught larvae wild-caught Species Ae. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. aegyptiAe. Source the of data 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) 2008 N°5, BASAG Girod et al. (2008) Dusfour et al. (2011) Dusfour et al. (2011) Dusfour et al. (2011)

SUPPLEMENTARY DATA