The Journal of PHARMACOLOGY

And Experimental Therapeutics

A Publication of the American Society for Pharmacology and Experimental Therapeutics

September 2006 Vol. 318, No. 3 Contents

PERSPECTIVES IN PHARMACOLOGY Role of Matrix Metalloproteinases in Intestinal Inflammation Carlos Medina and Marek W. Radomski 933

BEHAVIORAL PHARMACOLOGY Downloaded from Dose Effects of Propranolol on Cancellous and Cortical Bone N. Bonnet, N. Laroche, L. Vico, E. Dolleans, 1118 in Ovariectomized Adult Rats C. L. Benhamou, and D. Courteix Enhancement of -Like Effects but Not Brain- Tomasz Kos, Beata Legutko, 1128 Derived Neurotrophic Factor mRNA Expression by the Novel Wojciech Danysz, Gary Samoriski, and N-Methyl-D-aspartate Neramexane in Piotr Popik Mice jpet.aspetjournals.org Effects of Intrathecally Administered Nociceptin/Orphanin FQ M. C. Holden Ko, Hui Wei, 1257 in Monkeys: Behavioral and Mass Spectrometric Studies James H. Woods, and Robert T. Kennedy Interactions between an N-Methyl-D-aspartate Antagonist and Bradford D. Fischer and Linda A. Dykstra 1300 Low-Efficacy Receptor in Assays of Schedule- Controlled Responding and Thermal Nociception Neonatal Intrahippocampal Glycoprotein 120 Injection: The Sylvia Fitting, Rosemarie M. Booze, and 1352 Role of Dopaminergic Alterations in Prepulse Inhibition in Charles F. Mactutus at ASPET Journals on September 23, 2021 Adult Rats

CARDIOVASCULAR Chronic Matrix Metalloproteinase Inhibition Following Francis G. Spinale, G. Patricia Escobar, 966 Myocardial Infarction in Mice: Differential Effects on Short Jennifer W. Hendrick, Leslie L. Clark, and Long-Term Survival Sarah S. Camens, Joseph P. Mingoia, Christina G. Squires, Robert E. Stroud, and John S. Ikonomidis Beneficial Effects of Metolazone in a Rat Model of Gabriella Pridjian, Candice Pridjian, 1027 Preeclampsia Svitlana Danchuk, Monica Ianosi-Irimie, Hop V. Vu, and Jules B. Puschett L-Arginine Chlorination Results in the Formation of a Jian Yang, Ruirui Ji, Yunhui Cheng, 1044 Nonselective Nitric-Oxide Synthase Inhibitor Ju-Zhong Sun, Lisa K. Jennings, and Chunxiang Zhang Biotransformation of Glyceryl Trinitrate by Rat Hepatic Yanbin Ji and Brian M. Bennett 1050 Microsomal S-Transferase 1 Reduced Inotropic Effect of Nifekalant in Failing Hearts in Hideaki Endo, Masahito Miura, 1102 Rats Masanori Hirose, Jun Takahashi, Makoto Nakano, Yuji Wakayama, Yoshinao Sugai, Yutaka Kagaya, Jun Watanabe, Kunio Shirato, and Hiroaki Shimokawa

The Journal of Pharmacology and Experimental Therapeutics (ISSN Single copy: $82.00. GST Tax Number for Canadian subscribers: 0022-3565) is published monthly by the American Society for Phar- BN:13489 2330 RT. Indexed or abstracted by Biochemistry & Bio- macology and Experimental Therapeutics, 9650 Rockville Pike, physics Citation Index®, Biological Abstracts, BIOSIS Previews Data- Bethesda, MD 20814-3995; email: [email protected]; web site: base, BioSciences Information Services, Current Awareness in Bio- www.aspet.org. Periodicals postage paid at Bethesda, MD, and at ad- logical Sciences, Current Contents®/Life Sciences, EMBASE/ ditional mailing offices. POSTMASTER: Send address changes to The Excerpta Medica, Index Medicus, Medical Documentation Service®, Journal of Pharmacology and Experimental Therapeutics, 9650 Rock- PsycINFO, Reference Update®, Research Alert®, Science Citation ville Pike, Bethesda, MD 20814-3995. Subscription rates: U.S.: $817.00 Index®, SciSearch®, and SIIC Data Bases. Copyright © 2006 by the for institutions and $356.00 for non-ASPET members. Outside the American Society for Pharmacology and Experimental Therapeutics. U.S.: $964.00 for institutions and $502.00 for non-ASPET members. All rights reserved. Printed in the U.S.A. Intravenous Insulin-like Growth Factor-I Receptor Antisense Tien Thuy Nguyen, Nga Cao, 1171 Treatment Reduces Angiotensin Receptor Expression and Jennifer Lynn Short, and Paul James White Function in Spontaneously Hypertensive Rats Bradykinin and Its Metabolite Bradykinin 1–5 Inhibit Laine J. Murphey, Hector A. Malave, 1287 Thrombin-Induced Platelet Aggregation in Humans Jeff Petro, Italo Biaggioni, Daniel W. Byrne, Douglas E. Vaughan, James M. Luther, Mias Pretorius, and Nancy J. Brown Substituted Adamantyl-Urea Inhibitors of the Soluble Epoxide Jeffrey J. Olearczyk, Mary B. Field, 1307 Hydrolase Dilate Mesenteric Resistance Vessels In-Hae Kim, Christophe Morisseau, Bruce D. Hammock, and John D. Imig Effects of Adrenomedullin on Cardiac Oxidative Stress and Matlubur Rahman, Akira Nishiyama, 1323 Collagen Accumulation in Aldosterone-Dependent Malignant Peng Guo, Yukiko Nagai, Guo-Xing Zhang, Hypertensive Rats Yoshihide Fujisawa, Yu-Yan Fan, Shoji Kimura, Naohisa Hosomi, Koji Omori, Youichi Abe, and Masakazu Kohno Mitochondrial Arginase II Modulates Nitric-Oxide Synthesis Go¨kce Topal, Annie Brunet, 1368 through Nonfreely Exchangeable L-Arginine Pools in Human Laurence Walch, Jean-Luc Boucher, and Endothelial Cells Monique David-Dufilho

CELLULAR AND MOLECULAR ␣ Downloaded from -Adrenergic Receptors Exhibit Enhanced Surface Steven C. Prinster, Tomas G. Holmqvist, and 974 ␤ Expression and Signaling upon Association with 2- Randy A. Hall Adrenergic Receptors Collagenase-2 and -3 Mediate Epidermal Growth Factor Yurii V. Mukhin, Monika Gooz, 1033

Receptor Transactivation by Bradykinin B2 Receptor in John R. Raymond, and Kidney Cells Maria N. Garnovskaya Ethanol Destabilizes Liver Gal␤l, 4GlcNAc ␣2,6- Mamatha Garige, Maokai Gong, and 1076 jpet.aspetjournals.org Sialyltransferase, mRNA by Depleting a 3-Untranslated M. Raj Lakshman Region-Specific Binding Protein In Vitro and in Vivo Antitumor Effects of Cytotoxic Terry W. Moody, Li-Chun Sun, 1265 Camptothecin-Bombesin Conjugates Are Mediated by Specific Samuel A. Mantey, Tapas Pradhan, Interaction with Cellular Bombesin Receptors L. Vienna Mackey, Nieves Gonzales, Joseph A. Fuselier, David H. Coy, and

Robert T. Jensen at ASPET Journals on September 23, 2021 Alters Proliferation, Migration, and Differentiation of Shuxian Hu, Maxim C.-J. Cheeran, 1280 Human Fetal Brain-Derived Neural Precursor Cells Wen S. Sheng, Hsiao T. Ni, James R. Lokensgard, and Phillip K. Peterson

Greater Susceptibility of the Sarcoplasmic Reticulum to H2O2 Aude Lafoux, Alexandra Divet, 1359 Injuries in Diaphragm Muscle from mdx Mice Pascal Gervier, and Corinne Huchet-Cadiou

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY Effect of a Novel Vacuolar-H؉-ATPase Inhibitor on Cell and Giovanna Petrangolini, Rosanna Supino, 939 Tumor Response to Camptothecins Graziella Pratesi, Laura Dal Bo, Monica Tortoreto, Anna Cleta Croce, Paola Misiano, Pietro Belfiore, Carlo Farina, and Franco Zunino

Evaluation of Original Dual Thromboxane A2 Modulators as Xavier de Leval, Thibaut Dassesse, 1057 Antiangiogenic Agents Jean-Michel Dogne´, David Waltregny, Akeila Bellahce`ne, Vale´rie Benoit, Bernard Pirotte, and Vincent Castronovo Antitumor Activity of Plant with Emphasis on Alessia Ligresti, Aniello Schiano Moriello, 1375 the Effect of Cannabidiol on Human Breast Carcinoma Katarzyna Starowicz, Isabel Matias, Simona Pisanti, Luciano De Petrocellis, Chiara Laezza, Giuseppe Portella, Maurizio Bifulco, and Vincenzo Di Marzo

ENDOCRINE AND DIABETES Novel Mechanism of Chronic Exposure of Oleic Acid-Induced Takanori Kudo, Jie Wu, Yoshiji Ogawa, 1203 Insulin Release Impairment in Rat Pancreatic ␤-Cells Sechiko Suga, Noriyuki Hasegawa, Toshihiro Suda, Hiroki Mizukami, Soroku Yagihashi, and Makoto Wakui

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL Policosanol Inhibits Cholesterol Synthesis in Hepatoma Cells Dev K. Singh, Li Li, and Todd D. Porter 1020 by Activation of AMP-Kinase Induction of Rat Intestinal P-glycoprotein by Spironolactone Carolina I. Ghanem, Paula C. Go´mez, 1146 and Its Effect on Absorption of Orally Administered Digoxin Marı´a C. Arana, Marı´a Perassolo, Griselda Delli Carpini, Marcelo G. Luquita, Luis M. Veggi, Viviana A. Catania, Laura A. Bengochea, and Aldo D. Mottino Effect of Barley Endoprotease EP-B2 on Gluten Digestion in Jonathan Gass, Harmit Vora, 1178 the Intact Rat Michael T. Bethune, Gary M. Gray, and Chaitan Khosla Increased Apical Insertion of the Multidrug Resistance Sylvia Notenboom, Alfons C. Wouterse, 1194 Protein 2 (MRP2/ABCC2) in Renal Proximal Tubules Bram Peters, Leon H. Kuik, following Gentamicin Exposure Suzanne Heemskerk, Frans G. M. Russel, and Rosalinde Masereeuw Differential Roles for Cytosolic and Microsomal Ca2؉- Geraldine Saavedra, Wenliang Zhang, 1211

Independent Phospholipase A2 in Cell Growth and Brianna Peterson, and B. S. Cummings Maintenance of Phospholipids

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA Apolipoprotein E-Derived Peptides Ameliorate Clinical Feng-Qiao Li, Gregory D. Sempowski, 956 Disability and Inflammatory Infiltrates into the Spinal Cord Suzanne E. McKenna, Daniel T. Laskowitz, in a Murine Model of Multiple Sclerosis Carol A. Colton, and Michael P. Vitek Downloaded from □S Periplocoside E Inhibits Experimental Allergic Yi-Na Zhu, Xiang-Gen Zhong, 1153 Encephalomyelitis by Suppressing Interleukin 12-Dependent Jia-Quan Feng, Yi-Fu Yang, Yun-Feng Fu, CCR5 Expression and Interferon-␥-Dependent CXCR3 Jia Ni, Qun-Fang Liu, Wei Tang, Expression in T Lymphocytes Wei-Min Zhao, and Jian-Ping Zuo Effect of Natriuretic Peptide Receptor Antagonist on Michio Miyoshi, Yoshinori Kitagawa, 1163 Lipopolysaccharide-Induced Fever in Rats: Is Natriuretic Toshiaki Imoto, and Tatsuo Watanabe Peptide an Endogenous Antipyretic? jpet.aspetjournals.org Modulation of Thrombin-Induced Neuroinflammation in BV-2 Mohamed G. Bani-Hani, David Greenstein, 1315 Microglia by Carbon Monoxide-Releasing Molecule 3 Brian E. Mann, Colin J. Green, and Roberto Motterlini

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

□S Metabolism of Bergamottin by Cytochromes P450 2B6 and Ute M. Kent, Hsia-lien Lin, 992 3A5 Kathleen R. Noon, Danni L. Harris, and at ASPET Journals on September 23, 2021 Paul F. Hollenberg Ritonavir, Saquinavir, and , but Not Nevirapine, Mary Peace McRae, Carolina M. Lowe, 1068 Inhibit Bile Acid Transport in Human and Rat Hepatocytes Xianbin Tian, David L. Bourdet, Richard H. Ho, Brenda F. Leake, Richard B. Kim, Kim L. R. Brouwer, and Angela D. M. Kashuba Acetoxymethoxycarbonyl Nitroxides as Electron Paramagnetic Minoru Miyake, Jiangang Shen, Shimin Liu, 1187

Resonance Proimaging Agents to Measure O2 Levels in Mouse Honglian Shi, Wenlan Liu, Zhongrui Yuan, Brain: A Pharmacokinetic and Pharmacodynamic Study Aaron Pritchard, Joseph P. Y. Kao, Ke Jian Liu, and Gerald M. Rosen Intestinal and Hepatic Metabolic Activity of Five Cytochrome Aleksandra Galetin and J. Brian Houston 1220 P450 Enzymes: Impact on Prediction of First-Pass Metabolism Disposition and Sterol-Lowering Effect of Ezetimibe in Stefan Oswald, Sabine Westrup, 1293 Multidrug Resistance-Associated Protein 2-Deficient Rats Markus Grube, Heyo K. Kroemer, Werner Weitschies, and Werner Siegmund Urinary Metabolite Profiling Reveals CYP1A2-Mediated Chi Chen, Linghua Meng, Xiaochao Ma, 1330 Metabolism of NSC686288 (Aminoflavone) Kristopher W. Krausz, Yves Pommier, Jeffrey R. Idle, and Frank J. Gonzalez An Initial Assessment of the Systemic Pharmacokinetics of Easwaran Ravichandran, Yujing Gong, 1343 Botulinum Toxin Fetweh H. Al Saleem, Denise M. Ancharski, Suresh G. Joshi, and Lance L. Simpson

NEUROPHARMACOLOGY

□S Evaluation of Gabapentin and Ethosuximide for Treatment of Anthony J. Williams, Charisma C. Bautista, 947 Acute Nonconvulsive Seizures following Ischemic Brain Injury Ren-Wu Chen, Jitendra R. Dave, in Rats Xi-Chun M. Lu, Frank C. Tortella, and Jed A. Hartings

□S Sodium Orthovanadate Enhances Proliferation of Progenitor Jun Matsumoto, Motohiro Morioka, 982 Cells in the Adult Rat Subventricular Zone after Focal Yu Hasegawa, Takayuki Kawano, Cerebral Ischemia Yutaka Yoshinaga, Tatsumi Maeda, Shigetoshi Yano, Yutaka Kai, Kohji Fukunaga, and Jun-ichi Kuratsu The KCNQ Channel Opener Retigabine Inhibits the Activity Henrik H. Hansen, Christina Ebbesen, 1006 of Mesencephalic Dopaminergic Systems of the Rat Claus Mathiesen, Pia Weikop, Lars Christian Rønn, Olivier Waroux, Jacqueline Scuve´e-Moreau, Vincent Seutin, and Jens D. Mikkelsen Pharmacology of 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]- Victor I. Ilyin, James D. Pomonis, 1083 pyrimidine-4-carboxamide: A Potent, Broad-Spectrum State- Garth T. Whiteside, James E. Harrison, Dependent Sodium Channel Blocker for Treating Pain States Michelle S. Pearson, Lilly Mark, Paul I. Turchin, Susan Gottshall, Richard B. Carter, Phong Nguyen, Derk J. Hogenkamp, Shakira Olanrewaju, Elfrida Benjamin, and Richard M. Woodward ␣ Identification of Structures within GABAA Receptor Brandon C. Drafts and Janet L. Fisher 1094 Subunits That Regulate the Action of Identification and Pharmacological Profile of a New Class of Lisa M. Broad, Ruud Zwart, 1108 Selective Nicotinic Receptor Potentiators Kathy H. Pearson, Martin Lee, Louise Wallace, Gordon I. McPhie, Renee Emkey, Sean P. Hollinshead, Colin P. Dell, S. Richard Baker, and

Emanuele Sher Downloaded from The Effects of Long Chain-Length n-Alcohols on the Firing Sarah B. Appel, Leon Wise, John McDaid, 1137 Frequency of Dopaminergic Neurons of the Ventral Susumu Koyama, Maureen A. McElvain, Tegmental Area and Mark S. Brodie Pharmacological Characterization of Novel Water-Soluble Billy R. Martin, Jenny L. Wiley, 1230 Cannabinoids Irina Beletskaya, Laura J. Sim-Selley,

Forrest L. Smith, William L. Dewey, jpet.aspetjournals.org Jean Cottney, Julia Adams, James Baker, David Hill, Bijali Saha, John Zerkowski, Anu Mahadevan, and Raj K. Razdan A Novel Phospholipid Derivative of Indomethacin, DP-155 E. Dvir, J. E. Friedman, J. Y. Lee, 1248 [Mixture of 1-Steroyl and 1-Palmitoyl-2-{6-[1-(p- J. Y. Koh, F. Younis, S. Raz, I. Shapiro, chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl A. Hoffman, A. Dahan, G. Rosenberg, acetamido]hexanoyl}-sn-glycero-3-phosophatidyl ], I. Angel, A. Kozak, and R. Duvdevani Shows Superior Safety and Similar Efficacy in Reducing at ASPET Journals on September 23, 2021 Brain Amyloid ␤ in an Alzheimer’s Disease Model The Novel, Orally Active, Delta Opioid RWJ-394674 Is E. E. Codd, J. R. Carson, R. W. Colburn, 1273 Biotransformed to the Potent Mu Opioid, RWJ-413216 S. L. Dax, D. Desai-Krieger, R. P. Martinez, L. A. McKown, L. A. Neilson, P. M. Pitis, P. L. Stahle, D. J. Stone, A. J. Streeter, W. N. Wu, S. P. Zhang

TOXICOLOGY Adenovirus-Mediated Gene Therapy to Restore Expression Kristini K. Miles, Fay K. Kessler, 1240 and Functionality of Multiple UDP-Glucuronosyltransferase Laura J. Webb, Philip C. Smith, and 1A Enzymes in Gunn Rat Liver Joseph K. Ritter

ERRATUM Correction to “Interactions of Functionalized Feride Cengelli, Dusica Maysinger, 1388 Superparamagnetic Iron Oxide Nanoparticles with Brain Florianne Tschudi-Monnet, Xavier Montet, Structures” Claire Corot, Alke Petri-Fink, Heinrich Hofmann, and Lucienne Juillerat-Jeanneret

□S Supplemental material is available online at http://jpet.aspetjournals.org.

About the cover: Energy-based docking of BG into models of P450 2B6 and 3A5: differential exposure of geranyl side chain atoms. See the article by Kent et al. on page 992 of this issue.