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Koch Hemangiomas and Other Vascular Tumors Syllabus ASHNR 2018

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Koch Hemangiomas and Other Vascular Tumors Syllabus ASHNR 2018 Hemangiomas and Other Disclosures Vascular Tumors • No relevant financial disclosures Bernadette L. Koch, M.D. Departments of Radiology and Pediatrics Cincinnati Children’s Hospital Medical Center University Hospital Cincinnati, Ohio @CincyKidsRad facebook.com/CincyKidsRad Objectives History • Review clinical and imaging characteristics of infantile • 1982 – Mulliken & Glowacki – histology & hemangiomas and other vascular tumors with particular behavioral characteristics described attention to the revised ISSVA classification. • 1992 ISSVA formed, 1996 classification created – Increasing # of vascular lesions recognized as histologically distinct entities – Interval advances in understanding genetics and behavior of some lesions – Updated classification 2014 to guide appropriate therapies Misuse of nomenclature remains New ISSVA Classification widespread in the literature • Fundamental classification remains • Risk of inappropriate therapy – Vascular tumors vs malformations • True neoplasms with cellular (endothelial) proliferation vs • Best approach is multidisciplinary vascular congenital errors of vessel formation anomalies clinic • Lesions grow independent of patient size vs lesions grow – Hematologist-oncologist commensurate with the child • Malformations grow rapidly if hemorrhage, infection, or – Surgeon during periods of hormonal stimulation (puberty, – Dermatologist pregnancy) – Pathologist • Addition of evolving category of provisionally unclassified vascular anomalies – Radiologist/interventional radiologist ISSVA Classification Vascular Tumors, Benign • Subdivisions and lesion assignment/nomenclature modified to be more histologically precise • Infantile hemangioma • Vascular tumors • Congenital hemangioma – Benign – RICH, NICH, PICH – Locally aggressive or borderline • Tufted angioma – Malignant • Vascular malformations • Spindle-cell hemangioma – Simple • Epithelioid hemangioma – Combined • Pyogenic granuloma – Anomalies of major named vessel – Malformations associated with other anomalies • Others Infantile Hemangioma Infantile Hemangioma (IH) • Intense enhancement • Benign neoplasm • Proliferating endothelial cells • High flow vessels – GLUT-1 positive in all phases during proliferative • Presents shortly after birth phase – Proliferative phase - enlarge up to 2 yrs • Fatty infiltration during – Involuting phase - spontaneous regression several yrs. • 60% in H & N involuting phase – Parotid, orbit, nasal, suglottic, anterior/posterior neck • Tx - expectant • Majority single in subQ tissue waiting, oral • No imaging required propranalol, steroids, • Occasionally multiple, trans-spatial, deep • Further workup if segmental facial distribution, > 5 subQ lesions, laser tx, Rapamycin, midline lumbosacral excision Infantile Hemangioma • Additional work up recommended – Segmental facial distribution IH (PHACE syndrome) – 5 or more cutaneous IHs • Associated with hepatic IH – If large &/or multiple, may result in liver failure, heart failure, abdominal compartment syndrome, hypothyroidism – Midline lumbosacral/perineal IH • Associate with tethered cord/spinal abnormalities 9 years later PHACE Syndrome PHACE Syndrome • Posterior fossa malformations • Hemangiomas H&N • Arterial – Stenosis, occlusion, aneurysm • Cardiovascular 2 different patients – Coarctaion aorta, cardiac anomalies • Eye • Supra-umbilical & sternal clefts Congenital Hemangioma Imaging Congenital Hemangioma • Proliferation complete at/before birth • More heterogeneous than IH • GLUT-1 negative – Calcifications, hemorrhage, necrosis • Rapidly involuting (RICH) – Less T2 hyperintense vs. IH – Largely involuted by 12-15 months – Vessels more frequently visible on grayscale • Noninvoluting (NICH) US than IH – No change over time – High flow periphery +/- large feeding • Partially involuting (PICH) arteries/draining veins, especially in liver – No fibrofatty residua Rapidly Involuting Congenital Rapidly Involuting Congenital Hemangioma Hemangioma Rapidly Involuting Congenital Hemangioma Pyogenic granuloma • “Lobular capillary hemangioma” - Misnomer • Vascular tumor - ? at sites of prior trauma • H&N > trunk & extremities – Most common in children & pregnant women • Small erythematous papules – friable with tendency to bleed • Most removed without imaging • Hypintense T1/hyperintense T2 • Contrast enhancing • +/- iso/hypoattenuating cap on CECT • +/- bone displacement or erosion • Inferior turbinate >> nasal septum Lee et al. AJNR Am J Neuroradiol. 2010 Apr;31(4):749-54 Locally aggressive or Kaposiform hemangioendothelioma (KHE) borderline vascular tumors • Locally aggressive vascular tumor primarily found in infants • Kaposiform hemangioendothelioma • Kasabach-Merritt phenomenon • Retiform hemangioendothelioma – Sustained, profound consumptive coagulopathy • Papillary intralymphatic (thrombocytopenia, hypofibrinogenemia) due to intralesional trapping angioendothelioma (PILA), Dabska tumor • KHE, tufted angioma • Composite hemangioendothelioma – Occurs in 70% of patients with KHE • Kaposi sarcoma – Up to 30% mortality from hemorrhage • Retroperitoneum > skin > H&N, mediastinum • Other extremities Imaging KHE Kaposiform hemangioendothelioma (KHE) • Poorly defined, infiltrative • Heterogeneous enhancement • Cutaneous/subcutaneous vs. deep visceral/muscular • +/- edema, esp. if KMP • +/- prominent vessels Kaposiform hemangioendothelioma (KHE) Kaposi sarcoma • Associated with human herpesvirus 8 (HHV-8) • In H&N: skin, mucosa, lymph nodes • Nodular enhancing mass +/- skin thickening and subcutaneous edema • Hyper-attenuating adenopathy with heterogeneous enhancement • Adenoid enlargement Kaposi Sarcoma Vascular tumors, malignant • Angiosarcoma • Epithelioid hemangioendothelioma • Others Courtesy Dr. Shatzkes Angiosarcoma Imaging Angiosarcoma • 60% occur in H&N • Skin of scalp, face, neck > sinonasal, oral • Contrast enhancing scalp or soft tissue cavity, thyroid mass • Overall 5-year survival in adults < 30% • +/- underlying bone erosion • Nodal recurrence and hypervascular distal • Intermediate T1, hyperintense T2 +/- flow mets common voids – Lung, liver, bone • FDG PET: high FDG uptake Vascular Tumors Locally aggressive Benign Malignant or borderline Infantile hemangioma Kaposiform Angiosarcoma hemangioendothelioma Congenital hemangioma Epitheliod hemangioendothelioma Retiform hemangioendothelioma Tufted hemangioma Others Papillary intralymphatic angioendothelioma Spindle-cell hemangioma (PILA) Epithelioid hemangioma Composite hemangioendothelioma Pyogenic granuloma Kaposi Sarcoma Others Others .
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