Training for the Professional Operation of Indoor Tanning Salons 2016
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Mutagenesis by 8-Methoxypsoralen and 5-Methylangelicin Photoadducts in Mouse Fibroblasts: Mutations at Cross-Linkable Sites Indu
[CANCER RESEARCH 55, 1283-1288, March 15, 1995] Mutagenesis by 8-Methoxypsoralen and 5-Methylangelicin Photoadducts in Mouse Fibroblasts: Mutations at Cross-Linkable Sites Induced by Monoadducts as well as Cross-Links1 Edward J. Günther,Toni M. Yeasky, Francis P. Gasparro, and Peter M. Glazer2 Departments of Therapeutic Radiology ¡E.J. G., T. M. Y.. P. M. G.] and Dermatology ¡F.P. G.I, Yale University School of Medicine, New Haven, Connecticut 06520-8040 ABSTRACT center PUVA trial, Stem et al. (4) showed a statistically significant increase in the incidence of squamous cell carcinoma in PUVA Psoralens are used clinically in the treatment of several skin diseases, patients. A comparative analysis of the incidence of squamous cell including psoriasis, vitÃligo,and cutaneous T cell lymphoma. However, psoralen treatment has been associated with an increased risk of squa- carcinoma in the U.S. and European trials was recently reported (5). nious cell carcinoma of the skin. To elucidate molecular events that may While in earlier comparisons there appeared to be differences between play a role in the psoralen-related carcinogenesis, we examined psoralen- the European and American experience with PUVA-induced inci induced mutagenesis in a mouse fibroblast cell line carrying a recoverable, dence of squamous cell carcinoma, the ongoing periodic reanalysis of chromosomally integrated A phage shuttle vector. Using the stipi- gene as each set of data with a longer follow-up period now indicates com a mutation reporter gene, we determined the spectrum of mutations parable findings. induced by photoactivation of 8-methoxypsoralen and of 5-methylangeli- It is likely that these cancers arise from the mutagenic psoralen cin. -
Investigational Gel Rapidly Clears Actinic Keratosis
October 2008 • w w w. s k i n a n d a l l e rg y n ew s. c o m Cutaneous Oncology 25 Investigational Gel Rapidly Clears Actinic Keratosis B Y P AT R I C E W E N D L I N G tology practice in Tyler, Texas, and his as- extremities histori- Chicago Bureau sociates randomized 222 patients with 4- cally are more dif- Partial Clearance Rates for AK Lesions 8 visible AK lesions on the arm, shoulder, ficult to treat than C H I C A G O — Topical therapy for 2 or 3 chest, back, or scalp, to one of four treat- scalp lesions, the PEP005 0.05% days with the investigational agent in- ment groups. The primary end point was investigators per- for 3 days 75% genol mebutate, also known as PEP005, partial clearance, defined as the propor- formed an ad hoc provides substantial clearance of actinic tion of patients at day 57 with 75% re- analysis to com- PEP005 0.05% 62% keratosis lesions, according to findings duction in the number of AK lesions iden- pare outcomes in for 2 days from two phase II randomized studies. tified at baseline. patients with scalp “A comparison of efficacy outcomes with Treatment with PEP005 gel once daily and nonscalp le- PEP005 0.025% 56% those of studies of diclofenac, 5-FU [fluo- for 2 or 3 days produced significantly sions, Dr. Michael for 3 days S W E rouracil], and imiquimod shows at least greater lesion clearance in a dose-depen- Freeman of the N L Control vehicle A equivalent clearance of lesions over a much dent manner by all measures and at all dos- Skin Centre, Gold C 22% I for 3 days D shorter period,” Dr. -
Senate Committee on Ways and Means Senator David Ige, Chair Senator Michelle Kidani, Vice Chair Decision Making
American Cancer Society Cancer Action Network 2370 Nu`uanu Avenue Honolulu, Hawai`i 96817 808.432.9149 www.acscan.org Senate Committee on Ways and Means Senator David Ige, Chair Senator Michelle Kidani, Vice Chair Decision Making: February 20, 2014; 9:00 a.m. SB 2221 SD1 – RELATING TO TANNING Cory Chun, Government Relations Director – Hawaii Pacific American Cancer Society Cancer Action Network Thank you for the opportunity to provide written commnets in support of SB 2221 SD1, which prohibits the use of tanning beds for minors and requires warning notifications to customers. The American Cancer Society Cancer Action Network (ACS CAN) is the nation's leading cancer advocacy organization. ACS CAN works with federal, state, and local government bodies to support evidence-based policy and legislative solutions designed to eliminate cancer as a major health problem. Skin cancer is the most prevalent type of cancer in the United States, and melanoma is the third most common form of cancer for individuals aged 25-29 years. Ultraviolet (UV) radiation exposure from the sun is a known cause of skin cancer and excessive UV exposure, particularly during childhood and adolescence, is an important predictor of future health consequences. The link between UV exposure from indoor tanning devices and melanoma is consistent with what we already know about the association between UV exposure from the sun and skin cancer. This is why the International Agency for Research on Cancer (IARC) in 2009 elevated tanning devices to its highest cancer risk category – “carcinogenic to humans.”1 While sun exposure and tanning beds both produce potentially harmful UV radiation, powerful tanning devices may emit UV radiation 10 to 15 times higher than that of the 1 Ghissassi, et al. -
Comparative Study of Therapeutic Efficacy of Puva, Nbuvb and Puvasol in the Treatment of Chronic Plaque Type Psoriasis
COMPARATIVE STUDY OF THERAPEUTIC EFFICACY OF PUVA, NBUVB AND PUVASOL IN THE TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS Dissertation Submitted in Partial fulfillment of the University regulations for MD DEGREE IN DERMATOLOGY, VENEREOLOGY AND LEPROSY (BRANCH XX) MADRAS MEDICAL COLLEGE THE TAMILNADU DR.M.G.R. MEDICAL UNIVERSITY CHENNAI, INDIA. APRIL 2013 CERTIFICATE Certified that this dissertation titled “COMPARATIVE STUDY OF THERAPEUTIC EFFICACY OF PUVA, NBUVB AND PUVASOL IN THE TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS” is a bonafide work done by Dr.R.AKILA, Post graduate student of the Department of Dermatology, Venereology and Leprosy, Madras Medical College, Chennai – 3, during the academic year 2010 – 2013. This work has not previously formed the basis for the award of any degree. Prof.Dr.K.MANOHARAN MD.,D.D., Professor and Head of the Department, Department of Dermatology, Madras Medical College& Rajiv Gandhi Govt.General Hospital,Chennai-3. Prof. Dr.V. KANAGASABAI, M.D., Dean, Madras Medical College& Rajiv Gandhi Govt. General Hospital,Chennai-3. DECLARATION I, Dr.R.AKILA solemnly declare that this dissertation titled “COMPARATIVE STUDY OF THERAPEUTIC EFFICACY OF PUVA, NBUVB AND PUVASOL IN THE TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS” is a bonafide work done by me at Madras Medical College during 2010-2013 under the guidance and supervision of Prof. K.MANOHARAN, M.D.,D.D., Professor and head of the department of Dermatology, Madras Medical College,Chennai-600003. This dissertation is submitted to The Tamil Nadu Dr.M.G.R.Medical University, Chennai towards partial fulfillment of the rules and regulations for the award of M.D Degree in Dermatology, Venereology and Leprosy (BRANCH – XX) PLACE : DATE : (Dr. -
Phototherapy in Pediatric Patients: Choosing the Appropriate Treatment Option Rupa Pugashetti, BA* and John Koo, MD†
Phototherapy in Pediatric Patients: Choosing the Appropriate Treatment Option Rupa Pugashetti, BA* and John Koo, MD† Phototherapeutic modalities, including narrowband-UVB, broadband-UVB, PUVA photo- chemotherapy, and excimer laser therapy are valuable tools that can be used for photore- sponsive dermatoses in children. As a systematically safer alternative compared with internal agents, including the prebiologic and biological therapies, phototherapy should be considered a possible treatment option for children with diseases including psoriasis, atopic dermatitis, pityriasis lichenoides chronica, and vitiligo. Semin Cutan Med Surg 29:115-120 © 2010 Published by Elsevier Inc. hen choosing appropriate therapies for dermatologic adults. NBUVB represents a notable advance in phototherapy Wconditions in the pediatric population, clinicians and is considered more efficacious than BBUVB in the treat- must not only consider disease severity and morphology but ment of psoriasis, mycosis fungoides (MF), and vitiligo. also the general systemic safety profile of the treatment. For- NBUVB also has been increasingly tested in the pediatric tunately, many diseases, including psoriasis, atopic dermati- population as a therapy for diseases, including psoriasis, viti- tis, vitiligo, and pityriasis lichenoides, are photoresponsive ligo, pityriasis lichenoides, MF, and atopic dermatitis. dermatoses for which phototherapy represents an especially valuable treatment option. The pediatric population is a spe- Psoriasis cial population for whom it is important to avoid systemic agents and their associated potential risks whenever possible. Psoriasis is a chronic inflammatory skin disease that can be- Phototherapy represents a safe alternative for appropriately gin at any age and accounts for approximately 2% of visits to selected cases. There are 4 phototherapeutic options: nar- pediatric dermatologists. -
Indoor Tanning
INDOOR TANNING What is INDOOR TANNING? Using a tanning bed, booth, or sunlamp to get tan is called "indoor tanning." Indoor tanning is linked to skin cancers including melanoma (the deadliest type of skin cancer), squamous cell carcinoma, and cancers of the eye (ocular melanoma). What are the dangers of indoor tanning? Indoor tanning exposes users to both UV-A and UV-B rays, which damage the skin and can lead to cancer. Using a tanning bed is particularly dangerous for younger users; people who begin tanning younger than age 35 have a 75% higher risk of melanoma. Using tanning beds also increases the risk of wrinkles and eye damage, and changes skin texture. Is tanning indoors safer than tanning in the sun? Indoor tanning and tanning outside are both dangerous. Although tanning beds operate on a timer, the exposure to ultraviolet (UV) rays can vary based on the age and type of light bulbs. You can still get a burn from tanning indoors. A tan indicates damage to your skin. Can using a tanning bed to get a base tan, protect me from getting a sunburn? A tan is a response to injury: skin cells respond to damage from UV rays by producing more pigment. Prevent skin cancer by following these CDC tips: • Seek shade, especially during midday hours. • Wear clothing to protect exposed skin. • Wear a hat with a wide brim to shade the face, head, ears, and neck. • Wear sunglasses that wrap around and block as close to 100% of both UVA and UVB rays as possible. -
ACNE: 3 Tips That Matter COMMON DISORDERS THAT TRANSCEND AGE
NOVEMBER 2018 WITH SUNFLOWER DERMATOLOGY & MEDICAL DAY SPA IN THIS ISSUE: 2 Stump the Doctor 7 Ladies’ Night 3 Kind Words Update & Referral Program 5 Eclipse Rx News 8 Product of Staff Spotlight & 6 the Month Announcement ACNE: 3 Tips that Matter COMMON DISORDERS THAT TRANSCEND AGE Tip #1: Acne should NOT be treated by tanning. “Acne changes with A common misconception is that time age because hormones spent in a tanning bed will help alleviate acne. That’s simply not true. Phototherapy, change with age.” when used under the supervision of a – DR. MATTHYS doctor, can be beneficial to some skin issues, notably psoriasis. Going to an indoor tanning bed, however, is not the same thing as medically administered phototherapy. Not only is the light used during indoor tanning poorly defined, but the extent to which tanning salons comply with state and federal regulations is poor. “According to a study performed in North Carolina, the extent to which commercial tanning facilities comply is poor, with only 1 out of 32 commercial tanning establishments within complete compliance of state and federal guidelines.”[1] “The National Center for Biotechnology… Continued on Page 4 HAVE A QUESTION FOR OUR DOCTORS? EMAIL US AT [email protected] WITH SUBJECT LINE “Stump the Doctor” ? stump the doctor Q. Should I use only nature. For example, Digoxin, a “natural” products? treatment used for patients with heart disease, was extracted A. The internet, email and of from the Foxglove plant. And, course, TV, has made the while doxycycline, a treatment phenomenon of “all natural” used for acne, is not plant or quite pervasive in our culture. -
Light Therapy for Vitiligo
MEDICAL COVERAGE GUIDELINES ORIGINAL EFFECTIVE DATE: 06/11/14 SECTION: MEDICINE LAST REVIEW DATE: LAST CRITERIA REVISION DATE: ARCHIVE DATE: LIGHT THERAPY FOR VITILIGO Coverage for services, procedures, medical devices and drugs are dependent upon benefit eligibility as outlined in the member's specific benefit plan. This Medical Coverage Guideline must be read in its entirety to determine coverage eligibility, if any. The section identified as “Description” defines or describes a service, procedure, medical device or drug and is in no way intended as a statement of medical necessity and/or coverage. The section identified as “Criteria” defines criteria to determine whether a service, procedure, medical device or drug is considered medically necessary or experimental or investigational. State or federal mandates, e.g., FEP program, may dictate that any drug, device or biological product approved by the U.S. Food and Drug Administration (FDA) may not be considered experimental or investigational and thus the drug, device or biological product may be assessed only on the basis of medical necessity. Medical Coverage Guidelines are subject to change as new information becomes available. For purposes of this Medical Coverage Guideline, the terms "experimental" and "investigational" are considered to be interchangeable. BLUE CROSS®, BLUE SHIELD® and the Cross and Shield Symbols are registered service marks of the Blue Cross and Blue Shield Association, an association of independent Blue Cross and Blue Shield Plans. All other trademarks and service marks contained in this guideline are the property of their respective owners, which are not affiliated with BCBSAZ. Description: Vitiligo is an idiopathic skin disorder that causes depigmentation of sections of skin, most commonly on the extremities. -
Replacement of Tanning Lamps with Red Light Therapy Lamps in Tanning Salons
.~" ..,.", .... ,. .. "". I.~ ( ~~ DEPARTMENT OF HEALTH & HUMAN SERVICES " " Memorandum 4 ..... "" Date December 21, 2011 I' t From Director, CDRH Office of comPliance;{ /1 .' Subject Replacement of Tanning Lamps with Red Light Therapy Lamps in Tanning Salons To Conference of Radiation Control Program Directors (CRCPD) The Food and Drug Administration is aware that some tanning salon owners are removing the original ultraviolet (UV)-emitting tanning lamps from their tanning beds/booths and replacing them with lamps that emit red light. These salon owners are then selling sessions in the red light units with a range of indications and promotional claims, including ones pertaining to: • Reversal of sun or UV damage to skin, • wound healing, • increased blood flOW/Circulation, • reduced pain and/or inflammation, • treatment of acne, • reduction of appearance of wrinkles, pigmentation spots, stretch marks, and/or scarring, • skin rejuvenation, restoration, oxygenation, and/or hydration, • collagen/elastin production/reorganization, and • skin structure, elasticity, and/or metabolism. Ultraviolet tanning beds/booths/lamps meet FDA's definition of "device" and "electronic product" at sections 201(h) and 531 of the Federal Food, Drug, and Cosmetic Act (FD&C Act). Tanning lamps are subject to an electronic product performance standard, and are generally 510{k)-exempt. See 21 CFR 878.4635, part 1010, and 1040.20, Replacing the original ultraviolet lamps with lamps that emit red light and are intended for uses such as those listed above creates a new type of product that is also a "device" and an "electronic product" under the FD&C Act. Exposure to red light has been scientifically shown and is understood by consumers to affect skin structure, for example by reducing wrinkles for months after treatment, which may be the result of new collagen formation or reorganization, or repair of elastin damage. -
To Tan Or Not to Tan? Here Are the Facts!
TO TAN OR NOT TO TAN? HERE ARE THE FACTS! WHO GETS SKIN CANCER? WHAT ARE THE FACTS ABOUT Skin cancer is the most common cancer in the United States. TANNING AND TANNING BEDS? It affects men and women, oungy and old. Over 90 percent of • Persons who first use tanning beds before the age of 35 skin cancers are caused by exposure to ultraviolet (UV) light, increase their risk of melanoma by 75 percent. the same type of light that makes people tan. Skin cancer can be prevented by taking a few safety measures, such • Tanning beds are in the same cancer risk category as as wearing sunscreen, staying in the shade AND avoiding arsenic, tobacco smoke, the hepatitis B virus and artificial sources of UV light, such as tanning beds. radioactive plutonium. • There is no such thing as a “safe tan.” A base tan does WHAT IS SKIN CANCER? not protect from sunburn. In fact, a tan is the body’s natural response to UV rays and indicates that the skin Melanomas and nonmelanomas are the two categories of has been damaged. skin cancer. • Tanning beds use the same UV light as sunlight. Nonmelanomas (usually called basal cell and squamous cell Just 20 minutes in a tanning booth is the same as cancers) are the most common cancers of the skin. They are spending an entire day at the beach. also the easiest to treat if found early. These cancers are more common in older people. • UV rays break down the elasticity of the skin, causing premature aging, fine lines and wrinkles. -
United States Patent (19) 11 Patent Number: 4,967,090 Schlitt V 45 Date of Patent: Oct
United States Patent (19) 11 Patent Number: 4,967,090 Schlitt V 45 Date of Patent: Oct. 30, 1990 (54 COSMETCTANNING LAMP AND SYSTEM Primary Examiner-Jack I. Berman HAVING ADJUSTABLE UVB PROPORTON Attorney, Agent, or Firm-Carlo S. Bessone (75) Inventor: Steven C. Schlitt, Merrimac, Mass. (57) ABSTRACT (73) Assignee: GTE Products Corporation, Danvers, A fluorescent lamp and system for providing cosmetic Mass. tanning. The lamp includes a first ultraviolet-emitting phosphor disposed on a portion of the circumference of (21) Appl. No.: 520,320 the interior of an ultraviolet-transmitting glass enve 22 Filed: May 7, 1990 lope. A second ultraviolet-emitting phosphor is dis posed on the remaining portion the lamp envelope. The Related U.S. Application Data lamp further includes bases having electrical contacts (63. Continuation of Ser. No. 35,647, Feb. 27, 1989. extending therefrom and lying in a plane which passes through the demarcation lines formed between the first (51) Int. Cli.............................................. H01J 61/48 and second ultraviolet-emitting phosphors. In one em (52) U.S. C. ................................ 250/504 R; 313/487; bodiment, the proportions of UVB to UVA from the 128/396 same light source are about 1.6 percent and 4.2 percent. (58) Field of Search ........................ 250/504 R, 493.1; In another aspect of the invention, a suntanning system 313/487; 128/396 includes an external reflector positioned adjacent the 56 References Cited fluorescent lamp. The external reflector is effective in U.S. PATENT DOCUMENTS maintaining approximately the same irradiance level in the UVA region independent of the rotational align 3,466,443 9/1969 Roesler .......................... -
LSI Germicidal Catalog 2013 10-14-2013
Germicidal Lamps Creating True Value and True Partnership World Wide Suppliers of Quality Germicidal Lamps Company Profile: Founded in 1983, LightSources Inc. has been offering superior products and processes for over 25 years to our OEM customers and is the leading manufacturer of quartz germicidal lamps in the world. In 1993, LightTech Lamp Technology Ltd. was started in Hungary in order to serve the growing demand for germicidal lamps and sleeves for both the European and Asian markets. The combination of our state of the art manufacturing facilities, technology and capability allow us to bring quality products to the market with reduced lead times and high performance. Both companies design and manufacture lamps for a wide variety of special lighting applications spanning multiple market segments within many industries and applications. While both companies core focus remains on germicidal, photochemical and skin tanning applications, we also manufacture specialty lamps for LCD backlighting and compact fluorescent applications. Both companies are recognized within their respective markets for excellence in product design and manufacture and in meeting our customers' unique requirements for performance, quality and reliability. As true global organizations, our sales staff is available to serve you in several languages. UV-Action: g LightSources & LightTech low-pressure, mercury-arc germicidal lamps are specially designed to produce the highest amounts of uv radiation - where 90% of energy is typically generated at 254nm. This radiation is very close LAMP OUPUT vs. EFFECTIVENESS 100 to the peak of the germicidal effectiveness curve of 90 Peak Output Line of 265nm, the most lethal wavelength to microorganisms. 80 Germicidal Lamp at 253.7nm (see graph).