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BEHIND THE SCENES BEHIND THE SCENES “OUR WORK IS DRIVEN BY OUR COMPASSION FOR OTHERS AND A SENSE OF DEDICATION TO THE PATIENTS AND FAMILIES WHO TURN TO US FOR CANCER CARE. IT SHOWS IN ALL THAT WE DO, OFTEN TAKING PLACE QUIETLY BEHIND THE SCENES.”

— RICHARD I. FISHER, MD

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LITTLE THINGS, LARGE IMPACT

The people of Fox Chase Cancer ships with donors, colleagues, and Center have long embodied a spirit friends, we have so often shaped our of curiosity and innovation, achieve- future by focusing on little things that ment and progress. Our work is have large impact. driven by our compassion for others In any endeavor, and particularly in and a sense of dedication to the medicine, to delve deeper is to explore patients and families who turn to us the details. To experience the nuances for cancer care. It shows in all that we of our connections and collaborations. do, often taking place quietly behind To accomplish all that our potential the scenes. holds because we take care to recog- As we embark on a new era—one in nize things that may not be obvious which we integrate more fully as an to everyone, to address things that entity of Temple University Health only some bother to pursue, and to System—we reflect on the idea of learn from these observations and little things and the relationship they interactions for the betterment of our have with our broader world. patients and each other. This is a pivotal time in many Taken in total, our experiences regards. There are many issues and inform who we are as individuals and problems that surround us: the as an institution. These lessons are COVID-19 pandemic, racial injus- evident in how we approach our work tice, political division, and economic and the people we serve. All of the concerns. Amidst this backdrop, we little things we do and study and re- continue our pursuit of advancing member have a purpose. They illumi- cancer research and treatment. nate our opportunities, advance our We are welcoming new and deeper mission, and propel us to a greater collaborations as we renew our part- time to come. nership with Temple. Still, we hold As you read about the progress and close our values of respect, service, accomplishments of the last year at and quality. To move forward now is a Fox Chase, of the many selfless acts challenge that presents itself as both of our staff during these challenging exciting and overwhelming. times, I invite you to think about Despite this challenge, there is a how little things in your own life can path to be forged. Whether in the have the potential to effect change in clinical realm or the research lab, our larger world. Each of us has this through our administrative offices responsibility. The question we must and our hallways, or in our relation- ask ourselves is this: do I accept?

Richard I. Fisher, MD President and CEO at Fox Chase

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INSTITUTIONAL

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“I’M VERY HUMBLED TO BE HONORED WITH THIS AWARD IN MEMORY OF JAMIE LIEBERMAN AND THE IMPORTANT STRUGGLE SHE FOUGHT FOR.”

— RICHARD J. BLEICHER, MD, FACS

G44653_FCCC AR 20 Body p1-43 FINAL.indd 7 11/13/20 3:48 PM Richard J. Bleicher, MD, FACS, was awarded the 2020 Jamie Brooke Lieberman Remembrance Award from Susan G. Komen Philadelphia.

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FACULTY TEAM UP TO DEVELOP COVID-19 TEST

As COVID-19 began to spread across the country, Fox Chase Cancer Center clinical and administrative depart- ments teamed up to begin developing in-house COVID-19 testing, which began on April 9. “What became clear to us very quick- ly was that it was going to be more than just a lab effort. It really took pieces from all over the institution,” said Donald Baldwin, PhD, associate pro- fessor in the Department of Pathology. Baldwin took on some of the technical aspects of getting COVID-19 testing off the ground, while Mariusz Wasik, MD, procured resources and institutional support as the chair of pathology. testing, so our lab was faced with the workflow for sample receiving and The main overall project was led launching COVID-19 service in addi- tracking, quality control and assurance by Judy Bachman, MSN, RN, CNAA, tion to the usual demand of genomics protocols, and training and scheduling chief operating officer. Christine and molecular biology tests for cancer of techs and data coordinators. Bloom, MHA, RDMS, RT, director of patients,” said Baldwin. “Whoever we As they continued working, the radiation oncology, and Barbara Eber- called on was willing to help however process became more efficient. Test- sole, BFA, MA, CCC-SLP, assistant they could, so it’s been a real pleasure ing volume tripled since they began, research professor in the Division of to pull up an entire team to develop a and new equipment allowed them to Head & Neck Surgery, were co-leads. brand new test in record time.” process 96 samples at once. In addi- Marie Riehl, RN, clinical manager tion, they used to manually enter test of the outpatient department, set up results, but software automated that STAFFERS PITCH IN TO the testing. Numerous staff members part of the process. PROCESS COVID TESTS contributed to the effort as well. “This was Fox Chase at its finest, it “We did all this with very little After Fox Chase researchers developed was a total group effort,” Loser said. reduction in our normal oncology a test for detecting COVID-19, dozens “No request was too small. If we met of other staffers, lab techs and nurses an obstacle, someone found a way to among them, pitched in to see the test- overcome it.” ing process through to the end. “It started with a canopy, staff in WHEN TESTING BEGAN ON EVEN MASKED, CHAPLAIN coats and using umbrellas on a rainy APRIL 9, FOX CHASE TESTED CONVEYS COMPASSION day, with eight tests done on the first 8 PEOPLE; day. It grew into two tents and more As a staff chaplain at Fox Chase Cancer AT THE HEIGHT OF than 90 tests per day,” said Anne Loser, Center, one of the main tools at the THE PANDEMIC, MORE THAN a medical technologist who was in- disposal of Barbara Klimowicz are volved in several steps of the process. her words. In this time of COVID-19, 90 PEOPLE She worked closely with Raquel Den- even though a mask covers her face, A DAY WERE BEING TESTED. nis, clinical lab supervisor, and Quynh patients, their loved ones, and staff can Lam, lab manager for the Molecular Di- still hear her voice. And they can see agnostics Laboratory. Lam developed the steadfast support, love, compas-

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 10 11/13/20 3:48 PM Henry Chi Hang Fung, MD, FACP, FRCPE, is chair of the Department of Bone Marrow Transplant and Cellular Therapies at Fox Chase.

G44653_FCCC AR 20 Body p1-43 FINAL.indd 11 11/13/20 3:48 PM Namrata “Neena” Vijayvergia, MD, was named to The Pennsylvania Medical Society’s Top Physicians Under 40 list.

G44653_FCCC AR 20 Body p1-43 FINAL.indd 12 11/13/20 3:48 PM sion, and hope in her eyes. that offered at other cancer centers, Although the pandemic prevents a characteristic that has become STAFF IN DIAGNOSTIC IMAGING family from being with patients at known as “Fox Chaseness.” Even in HAVE A MEDIAN OF WELL OVER bedside, or in infusion and radiation uncertain times, Fox Chase employ- areas, Klimowicz steps in to lend ees continued to provide a uniquely 20 YEARS support wherever and whenever loved caring environment for patients. OF SERVICE TO FOX CHASE. ones can’t. Staff are also included in One shining example of this is her rounds. She provides “Hope Hud- Lucille Williams, reception supervi- dles” throughout the center to provide sor in the Department of Radiation emotional and spiritual support as Oncology. Williams noticed a patient WORKING OVERTIME TO needed during these difficult times. was still waiting for a ride two hours KEEP EVERYONE SAFE “I travel around the world every day after his appointment had ended. as people take me with them on their She became concerned and called Fox Chase relies on the work of journeys of life,” Klimowicz said. the patient’s daughter, only to find environmental services (EVS) to keep out she had been in a car accident the center clean and sterile, and their and was running late. help was even more critical during STAFF MEMBERS TRACK Williams told the patient what had the COVID-19 pandemic. EVS staff DOWN RESPIRATORS happened. After learning that he had worked tirelessly to meet the needs of In mid-March, as it became clear not eaten all day, she took him to the patients and staff, and helped ensure that COVID-19 could reach pandemic cafeteria to buy him lunch and kept the hospital’s safety with increased levels, feared shortages of medical him company. cleaning measures. supplies had not yet become an issue at Fox Chase Cancer Center. But that didn’t stop employees from preparing for possible shortages with longer shifts and increased efforts to obtain necessary equipment. Two such staff members are Tracey Hunter, supervisor of respiratory care, and Paul Maher, a respiratory therapist. The two made numerous calls to obtain more ventilators for patients. Despite a national shortage of ventilators due to the emerging pandemic, Hunter and Maher were eventually able to obtain additional ventilators. “When we were short staffed, people were volunteering, staying longer, and doing whatever was necessary to meet the needs of the patient,” said Hunter.

EMBODYING ‘FOX CHASENESS’

Fox Chase Cancer Center prides itself on care and service that goes above

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Jonathan Wright, EVS director, said he was never more proud of his staff than when they continued to step up to the plate. “The EVS management team has been extraor- dinary,” he said. EVS staff, many of whom are individuals over 60 at higher risk of contracting COVID-19, cancelled previously scheduled time off to come to work every day to improve the hospital’s safety, Wright said. They also put patients at ease, said Kathy Rich, supervisor of house- in ambulatory care and started a find the ring on their own, they had to keeping. “The thing about Fox Chase clothing drive,” Briscella said. It was go home, a three-hour drive to the Lake is that EVS staff is close with the “very successful,” with about 30 bags Wallenpaupac area of the Poconos. patients. … It’s pretty impressive.” of clothing collected in a few months. Miller happened to be there when Although temporarily put on hold due the call came in to Fox Chase and to the COVID-19 pandemic, the drive volunteered to try to find the ring. “I SERVICE TO PATIENTS, is scheduled to start back up. thought, ‘Hey, let’s take a look. Maybe I SERVICE TO THE can find it.’” He took the couch down to COMMUNITY the maintenance area and after a half MAINTAINING SERVICE TO Caralyn Briscella, BSN, RN, OCN, hour, he was able to retrieve the ring. PATIENTS AND CAREGIVERS has been an infusion room nurse at Fox Chase for 8 years. When she’s not Dave Miller, a maintenance mechan- THE IMAGE OF DEDICATION serving her patients, she’s working to ic, has worked at Fox Chase for 20 serve the larger community. years and has gone out of his way for Long before the COVID-19 pandemic One of the infusion room’s long- patients and their families a number erupted, radiology technologists in term patients is a nurse at Friends of times. But his biggest accomplish- the Department of Diagnostic Imag- Hospital. She told Briscella about ment in that area may be helping a ing were on the front lines providing how patients are often transferred patient’s family by taking apart a sofa. X-rays, Cat Scans, or other forms to Friends in a hospital gown or with A family called maintenance at Tem- of imaging that patients required. just the clothes on their back, which ple University Health System, asking if And when the pandemic blew up, is especially a problem in the winter. they could buy a sofa from a Fox Chase they continued doing what they had “I knew I had to help. I reached waiting room because they believed a always done. “We are one of the first out to my coworkers and others family member had lost a wedding ring ones to come in contact with patients in it during an appointment. on a daily basis,” said Christine Dool- A man was with his wife, who had ey, a diagnostic radiology supervisor. come in for surgery, but she didn’t know Joan Keiper, administrative director FOX CHASE CANCER CENTER– she couldn’t have any jewelry with her. of diagnostic imaging, said the group BUCKINGHAM MARKED ITS So she gave the ring to her husband, is highly dedicated and experienced, who put it in his pants pocket. It fell out with a median of well over 20 years TH as he was waiting for her on the sofa. of service to Fox Chase. “They are 10 But in the end, his wife didn’t have professional and have jumped to the ANNIVERSARY. her surgery because she was found to call when needed in rough times. Be have an elevated heart rate during her it a snow storm or pandemic, they are preoperative screening. After trying to always there and ready to lend a hand.”

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 14 11/13/20 3:48 PM Kathy Rich (left) and Jonathan Wright (right) worked hard to keep the hospital clean during the COVID-19 pandemic.

G44653_FCCC AR 20 Body p1-43 FINAL.indd 15 11/13/20 3:48 PM Reception supervisor Lucille Williams went out of her way to help a patient and even bought him lunch.

G44653_FCCC AR 20 Body p1-43 FINAL.indd 16 11/13/20 3:48 PM A DEDICATED GROUP OF 401 VOLUNTEERS DONATED for International Blood & Marrow BLEICHER RECEIVES Transplant Research, of the 180 trans- BREAST CANCER AWARD 69,583 plant centers in the United States, HOURS OF SERVICE. Richard J. Bleicher, MD, FACS, a pro- only 12 adult and five pediatric centers fessor in the Department of Surgical were rated as performing above ex- Oncology at Fox Chase, was awarded pectations in 2019. Fox Chase was the the 2020 Jamie Brooke Lieberman only adult center in the tristate area associate professor in the Depart- Remembrance Award from Susan G. and one of only two in Pennsylvania to ment of Surgical Oncology, and Komen Philadelphia for his work in achieve this distinction. Namrata “Neena” Vijayvergia, MD, the breast cancer community. In addition to serving as depart- assistant chief of gastrointestinal The award’s namesake, Jamie ment chair, Fung, a professor of medical oncology in the Department Brooke Lieberman, lost her battle medical oncology, has also served as of Hematology/Oncology. Reddy with inflammatory breast cancer chief of the Section of Hematologic specializes in pancreatic cancer and in 2012 at the age of 35. She fought Malignancies and has been recog- neuroendocrine tumors, and Vijay- for understanding and awareness of nized as a top doctor three years in a vergia specializes in neuroendocrine her disease and was active in raising row by Philadelphia magazine. tumors and colorectal cancer. funds for research and community Honorees were nominated by col- outreach, early detection, and treat- leagues and selected by a committee TWO NAMED ‘TOP ment programs. of PAMED members. To appear on the PHYSICIANS UNDER 40’ “Although I never got to meet Ja- list, physicians must practice in Penn- IN PENNSYLVANIA mie, I’m very humbled to be honored sylvania and be under the age of 40 on with this award in memory of Jamie Two Fox Chase Cancer Center doc- December 31, 2020. The 45 physicians Lieberman and the important strug- tors were honored by The Pennsyl- on the 2020 list represent 19 differ- gle she fought for,” Bleicher said. vania Medical Society (PAMED) ent medical specialties. According to by being named to their list of this PAMED, this select group has demon- year’s Top Physicians Under 40. The strated a significant amount of success BONE MARROW two were Sanjay S. Reddy, MD, FACS, early in their medical careers. TRANSPLANT PROGRAM BECOMES A DEPARTMENT

The Fox Chase-Temple University Hospital Bone Marrow Trans- plant (BMT) Program is now the newest department at Fox Chase. The Department of Bone Marrow Transplant and Cellular Therapies is chaired by Henry Chi Hang Fung, MD, FACP, FRCPE, who was director of the BMT Program and is also vice chair of the Department of Hematol- ogy/Oncology. “With the emerging development of cellular therapy and the impor- tance of its role in oncology, we felt it warranted a separate department,” said Richard I. Fisher, MD, president and CEO of Fox Chase. In a review performed by the Center

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practice,” said Deborah Baldassarre, MSN, RN, OCN, NPD-BC, Nursing Residency Program Coordinator. “It was a great experience for all of us here, to look at our program, evaluate it, and make it better.” The ANCC Practice Transition Ac- creditation Program validates hospi- tal residency or fellowship programs that transition registered nurses and advanced practice registered nurses into new practice settings that meet rigorous, evidence-based standards for quality and excellence. Nurses in accredited transition programs such as Fox Chase’s Nurse Residency Program experience cur- ricula that promote the acquisition of knowledge, skills, and professional behaviors necessary to deliver safe, National Cancer Institute-designated high-quality care. FOX CHASE OUTPERFORMS cancer centers, to Magnet hospitals, PEERS, ACCORDING TO and to American Hospital Association SURVEYS EMPLOYEE CANCER Region 2 hospitals, which cover New SCREENING INITIATIVE Fox Chase consistently outperforms Jersey, New York, and Pennsylvania. LAUNCHES peer institutions in patient satisfaction These highly competitive groups surveys, according to Press Ganey data, include many institutions that In October 2019, Fox Chase kicked the most recent of which was released regularly score higher than peers in off its Employee Cancer Screening for the period of October through the general Press Ganey database, Initiative. The program focuses on December 2019. Overall scores and making it particularly impressive to providing education and screening percentile rankings for the center are outperform them. for a variety of cancers, including up across most surveys. breast, lung, colorectal, and head Press Ganey measures performance and neck cancer, to all eligible staff NURSING RESIDENCY against Fox Chase’s peers, comparing members. PROGRAM EARNS the center’s performance to other “While cancer education and ACCREDITATION screening are mainstays of our Fox Chase Cancer Center has an- community-based efforts, we also nounced that its Nurse Residency recognize the importance of focus- FOX CHASE REGISTERED Program achieved Practice Transi- ing our attention right here within tion Accreditation from the Amer- our institution,” said Richard I. 119,836 ican Nurses Credentialing Center Fisher, MD, president and CEO of OUTPATIENT VISITS AND (ANCC). They were awarded Accred- Fox Chase. “As we provide cancer itation with Distinction, the highest prevention, early detection, and 6,738 recognition awarded. treatment to our patients, it is NEW PATIENTS. “This accreditation validates our equally important that we maintain program for being evidence-based, good health and engage in preven- current, and relative to nursing tive care ourselves.”

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 18 11/13/20 3:48 PM Staff chaplain Barbara Klimowicz began holding “Hope Huddles” to boost morale during the COVID-19 pandemic.

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 20 11/18/20 11:21 AM “THE EXACTVU SYSTEM NOT ONLY ALLOWS THE UROLOGIST TO EVALUATE FOR NEW LESIONS OF CONCERN, BUT ALSO TRACKS PREVIOUSLY OBSERVED LESIONS OVER TIME SO WE CAN BETTER GAUGE IF THE CANCER IS CHANGING.”

— ANDRES F. CORREA, MD

G44653_FCCC AR 20 Body p1-43 FINAL.indd 21 11/13/20 3:48 PM Andres F. Correa, MD, has spearheaded the use of a new imaging technology for the diagnosis of prostate cancer.

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lesions of concern, but also tracks NEW MICRO-ULTRASOUND previously observed lesions over time IMAGING TECHNOLOGY so we can better gauge if the cancer is THE MOST COMMON TYPES Fox Chase has purchased a new changing,” Correa said. He added that OF CANCER AMONG PATIENTS micro-ultrasound system that physi- Rosalia Viterbo, MD, FACS, an asso- TREATED AT FOX CHASE WERE cians say could change the way pros- ciate professor in the Department of tate cancer is diagnosed and treated. Surgical Oncology, was “instrumen- PROSTATE The ExactVu Micro-Ultrasound tal” in securing the funds to purchase , System builds upon the standard the technology, which was raised (18%) transrectal ultrasound, typically used from patients and other donors. for prostate procedures, by featuring BREAST a 300% improvement in resolution, MINT REFRESHES CANCER allowing physicians to identify % , IMAGING AND ASSESSMENT (15 ) prostate cancer tumors with accuracy comparable to MRI. Determining how to treat patients LUNG The ExactVu system is an excit- diagnosed with cancer can be chal- ing addition to Fox Chase and the lenging, but there are other hurdles (10%), Philadelphia region, as it provides to overcome once treatment begins. one of the most cutting-edge imaging One is assessing how well patients are AND GYNECOLOGICAL technologies available for the diagno- progressing by tracking the size of sis and treatment of prostate cancer, tumors and other responses. (9%). said Andres F. Correa, MD, assistant To do this more effectively, Fox professor in the Department of Chase recently launched the Diag- Surgical Oncology. nostic Imaging Research Protocol “The ExactVu system not only al- Lab, a virtual lab designed to provide response assessments for clinical lows the urologist to evaluate for new accurate and consistent treatment trial patients. The assessments are conducted by radiologists who have expertise in cancer imaging and treatment response criteria. The lab features MINT Lesion Soft- ware from MINT Medical, said Jordan Anaokar, MD, the director of the lab and an associate professor in the Department of Diagnostic Imaging. The software helps provide immediate feedback on how patients are re- sponding to treatment, with graphical representation of tumor response. After radiologists identify tumors to be tracked on the baseline study, the software automatically finds them on the follow-up studies. The radiologists can then confirm that the tumor is the same one that was measured initially and provide a new measurement, features that stream- line the review process and minimize

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pher J. Manley, MD, an assistant pro- fessor and director of Interventional Pulmonology. Manley has started a prospective clinical trial studying the safety and feasibility of incorporating nee- dle-based confocal laser microscopy with the Monarch Platform. The study is in partnership with the Uni- versity of Amsterdam and support- ed by Mauna Kea Technology and Johnson and Johnson. The platform was purchased through funds raised from In Vino Vita, Fox Chase’s annu- al signature fundraising event.

MULTICENTER PANCREATIC CYST TRIAL LAUNCHES

An eight-year, multicenter study of pancreatic cysts funded by the Nation- errors. “That accuracy could make al Cancer Institute launched in spring FURTHER EVIDENCE AND Fox Chase more attractive for clinical 2020. Cysts are commonly identified KUDOS FOR ROBOTIC trials,” Anaokar said. lesions that can evolve into pancreatic BRONCHOSCOPY Margaret von Mehren, MD, chief cancer. Fox Chase is the headquarters of the division of sarcoma medical In the first published study since for the project, although the trial is oncology, championed the purchase the market release of robot-assisted open to participation at hundreds of of the system, which was funded by bronchoscopy, researchers at Fox sites around the country. money raised by In Vino Vita, Fox Chase found the technology to be The main focus of the new trial is Chase’s signature fundraising event. safe, feasible, and reliable for achiev- to compare the clinical effectiveness ing diagnoses for lung cancer. The of two surveillance strategies used diagnostic technology is used to view to track pancreatic cysts. Research- the inside of the lungs and obtain ers will also look at the costs of cyst PATIENTS UNDERWENT tissue samples for biopsy. surveillance, the impact on patients A VARIETY OF TREATMENTS, Fox Chase was one of the first of long-term follow-up, and attempt to INCLUDING SURGERY cancer centers in the nation to obtain identify novel molecular markers and this technology, marketed as the radiology findings that may predict (4,477), Monarch Platform. In addition, Fox the behavior of these cysts, said David RADIATION THERAPY Chase was honored with the Life S. Weinberg, MD, MSc, chair of the Sciences Pennsylvania 2019 Patient Department of Medicine at Fox Chase (28,002), Impact Award for pioneering use of and principal investigator for the trial. AND CHEMOTHERAPY the system. “Nobody’s under any illusion “Compared with traditional that either surveillance strategy as INFUSIONS bronchoscopy, this new technology currently written is good enough. . provides improved reach and dexter- They are the best we have for now, but (62,883) ity, affording us the ability to biopsy we are looking for something better,” small nodules safely,” said Christo- Weinberg said.

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 26 11/13/20 3:48 PM Jordan Anaokar, MD, directs a lab that uses diagnostic imaging to provide consistent assessments for clinical trial patients.

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 28 11/18/20 12:43 PM “WE USE MOUSE MODELS TO UNDERSTAND HOW SOME OVARIAN CANCERS INITIATE IN THE FALLOPIAN TUBE AND SPREAD TO THE OVARY AND TO LEARN HOW TO INHIBIT THE GROWTH OF THESE TUMORS.”

— DENISE CONNOLLY, PHD

G44653_FCCC AR 20 Body p1-43 FINAL.indd 29 11/13/20 3:48 PM Denise Connolly, PhD, received the Sandy Rollman Ovarian Cancer Foundation’s Teal Trailblazer Award.

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It turns out that ZBP1 “sees” INFLUENZA FINDINGS Z-RNA, a new form of RNA produced COULD HAVE KEY IMPACT RESEARCHERS HAD by influenza virus. “Folks have been ON CANCER THERAPIES looking for Z-RNA for decades. This A scientist at Fox Chase clarified a particular structure of RNA is what is 644 fundamental host defense mecha- called a pathogen-associated molec- SCIENTIFIC ARTICLES nism that detects the presence of ular pattern, and discovering a new PUBLISHED. influenza virus and rapidly destroys such pattern is a major milestone. It infected cells. also has significant implications for The new findings have exciting cancer immunotherapies, because implications for a variety of fields, drugs that activate ZBP1 have strong certain chemotherapies. including cancer immunotherapy, potential for combinatorial use with Mutations in the BRCA1 and said Siddharth Balachandran, PhD, immune checkpoint agents such as BRCA2 tumor suppressor genes lead author of the study and professor nivolumab,” Balachandran said. are the strongest known genetic in the Blood Cell Development and risk factor for breast and epithelial Function program. ovarian cancer. In addition, inherited FOX CHASE RESEARCHERS In previous research, Balachan- mutations in BRCA genes are now un- PROVIDE NEW INSIGHTS dran and other researchers had iden- derstood to contribute to other cancer INTO BRCA-MUTATED tified a protein called ZBP1 that is types, including colon and prostate. CANCERS essential for sensing the presence of Although BRCA genes increase can- influenza virus in lung cells. But they In two studies conducted at Fox cer risk, tumors with such mutations did not know how ZBP1 was being Chase, researchers have uncovered are particularly sensitive to some activated. “In other words, what was processes that may contribute to the forms of cancer therapy. ZBP1 ‘seeing’ that told it the cell was development of BRCA-mutated can- “The findings have implications for infected? Now, we know the answer,” cers and have also shed light on the cancer therapy because drugs known Balachandran said. response and resistance of cancers to as PARP inhibitors successfully treat BRCA1-mutant breast and ovarian cancers,” Neil Johnson, an associate professor in the Molecular Thera- peutics Program at Fox Chase, said of one of the studies. “Our work suggests different mutations may disable DNA repair by different mechanisms and could impact response and resistance to PARP inhibitors.” In the other study, Johnson and colleagues identified the protein RNF168 as a key component of the BRCA DNA repair pathway. In individuals without mutated BRCA1 and BRCA2 mutations, the proteins produced by these genes play a major role in repair of DNA, protecting it from mutations. This function is lost when the BRCA genes are mutated. Johnson and colleagues showed that when BRCA1 is absent, excessive

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 32 11/13/20 3:48 PM RNF168 expression increases DNA damage when cells replicate and con- tributes to the high level of mutation seen in BRCA1-mutated cancers. His laboratory is seeking to understand how cells regulate levels of RNF168 expression, what additional functions RNF168 performs, and how this path- way can be targeted for the develop- ment of new cancer drugs.

CONNOLLY WINS AWARD FOR OVARIAN CANCER RESEARCH

Denise Connolly, PhD, an associate professor in the Molecular Therapeu- tics Program at Fox Chase, received the Sandy Rollman Ovarian Cancer Foundation’s Teal Trailblazer Award. Connolly is currently researching a subtype of ovarian cancer — high- grade serous carcinoma — in mouse models to understand why not all ovarian cancer arises in the ovaries. “Some ovarian cancer arises outside of the ovary and travels to the ovary,” she said. “When the patient is diagnosed, it looks like the ovaries are the main site of involvement. We use mouse models to understand how some ovarian cancers initiate in the fallopian tube and spread to the ovary and to learn how to inhibit the growth of these tumors.”

FOX CHASE RESEARCHERS received a Research Scholar Grant His research specifically focuses on a HONORED AS AMERICAN for $792,000 to support research on protein called RNF168 that recruits CANCER SOCIETY GRANTEES the elucidation and exploitation of multiple proteins involved in the In November 2019, three Fox Chase molecular pathways that support DNA damage response. researchers were honored as new leukemia. Jaye Gardiner, PhD, a postdoctoral grantees by the American Cancer John Krais, PhD, a postdoctoral researcher in the lab of Edna Cukier- Society at its Philadelphia office. researcher in the lab of Neil Johnson, man, PhD, received a $163,500 grant Stephen M. Sykes, PhD, assistant PhD, received a grant for $107,500 to to support her research into the role of professor in the Blood Cell Devel- improve understanding of DNA re- the tumor stroma, or the tumor micro- opment and Function Program, pair pathways in BRCA1-mutant cells. environment, in pancreatic cancer.

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FIVE UP-AND-COMING FACULTY ON THE CUTTING EDGE

Fox Chase Cancer Center is known for innovation in cancer treatment, \ 2 \ quality patient care, and cutting-edge Israel Cañadas, PhD, is an as- THREE RESEARCHERS research. The following are some up- sistant professor in the Blood Cell and-coming researchers at Fox Chase Development and Function program WERE HONORED BY THE and Temple Health who are doing at Fox Chase. Cañadas studies tumor AMERICAN CANCER SOCIETY work that could lead to the latest immunity and the tumor microenvi- WITH NEW GRANTS breakthroughs in cancer prevention, ronment in lung cancer, with the goal WORTH A TOTAL OF diagnosis, and treatment. of breaking therapy resistance. He is developing novel platforms that will $1,063,000. allow him to identify and character- \ 1 \ ize new mechanisms of response and Ross Wang, PhD, is an assistant resistance to immunotherapy. professor in the Molecular Thera- to study how tumor microenviron- peutics Research Program at Fox ments control the metastasis of Chase and an assistant professor \ 3 \ tumor cells. She is currently investi- for the College of Science and Shannon Lynch, PhD, MPH, is an gating motile tumor cells in primary Technology in the Department of assistant professor in the Cancer tumors with the goal of building a Chemistry at Temple University. Prevention and Control Research predictive model of tumor cell entry His lab develops chemical probes to Program. Her work focuses on iden- into blood vessels. dissect posttranslational modifica- tifying multilevel gene and environ- tion-related proteins that are key to mental factors that can work together tumor cell metastasis. Wang and the to influence cancer risk, prognosis, \ 5 \ molecular therapeutics team work to and cancer-related health disparities. J. Nicholas Bodor, MD, PhD, MPH, improve cancer therapy by targeting Specifically, she applies machine is a physician and researcher in the tumor cells through new clinical trial learning and geospatial methods Department of Hematology/Oncology strategies. to discover patterns in multilevel in the Thoracic Oncology program. risk factor data that can be used to He is currently working with Margie identify patients and communities L. Clapper, PhD, deputy scientific disproportionally impacted by cancer director, to better understand the A TOTAL OF and who are in need of cancer inter- causative factors for non-small cell vention and outreach efforts. lung cancer in individuals who have 260 never smoked. RESEARCH PROJECTS \ 4 \ WITH Bojana Gligorijevic, PhD, is an associate professor in the Cancer Bi- $54 ology Research Program at Fox Chase MILLION as well as an associate professor of IN TOTAL COSTS RECEIVED Bioengineering and director of light FUNDING. microscopy in the College of Engi- neering at Temple University. Her lab uses real-time, intravital microscopy

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\ 4 \

\ 3 \

\ 2 \

\ 1 \

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 36 11/18/20 12:43 PM “I’M SO PROUD OF ALL WE’VE DONE TOGETHER AS TRACI’S TRIBE. I THINK WE HAVE WORKED SO HARD, AND TRACI WOULD BE SO PROUD OF EVERYTHING WE’VE ACCOMPLISHED.”

— CAROLINE “CASEY” STONE

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FUNDRAISING GOES VIRTUAL

The healthcare landscape looks quite different today than it did when 2020 began. Fox Chase has focused not only on responding to the pandemic, but also on caring for its vulnerable patients, something that has changed the face of fundraising. Although in-person events, long a vital part of philanthropic efforts, have been a casualty of the COVID-19 pandemic, Fox Chase fundraising is going strong in a virtual environ- ment. Fox Chase has seamlessly adapted and continues to raise funds, honor its supporters, and strengthen its donor community. through event postponements and pan- dog walk the past two years. The walk Some events have moved online demic conditions, they have contribut- raised $150,000 in October 2019, the or are being rescheduled, including ed $17 million this year, exceeding the highest amount in the event’s 20- Fox Chase’s largest fundraiser, In year’s fundraising goal by $1 million. year history. Vino Vita, and Paws for the Cause. As if all those good works weren’t For the first time, the Laurel Society enough, two former West CEOs are WEST PHARMACEUTICAL President’s Reception and Annual Fox Chase board members and past SERVICES MARKS TWO Donation Meeting for the Board of chairs of In Vino Vita, the center’s DECADES OF GIVING Associates were held online. In ad- signature fundraiser. Recognizing dition, more than 1,000 people sent By packaging and designing deliv- this powerful alliance between the messages of support to patients strug- ery systems for many cancer drugs, for-profit and nonprofit worlds, gling without family or friends to West Pharmaceutical Services Inc. the Philadelphia Business Journal accompany them during treatments literally ensures the safety of a vital awarded West its Faces of Philanthro- due to COVID-19 restrictions. aspect of cancer care. But their role in py award in 2018. And in 2020, West It is a true testament to the dedi- Fox Chase Cancer Center’s mission Pharmaceutical Services accepted cation of Fox Chase donors that even doesn’t end there. For the last two the inaugural Fox Chase corporate decades, the international company, service award. based in Exton, Pa., has been one of Fox Chase’s most loyal philan- FOX CHASE STAFF RECEIVE thropic partners. THE SINGLE LARGEST GIFT FOOD, OTHER DONATIONS West’s charitable arm, the Herman IN 2020 WAS DURING COVID-19 FIGHT O. West Foundation, established an endowed chair at Fox Chase in 2005. As COVID-19 began to put a strain on $2.6 Each year, its employees run a West hospitals in mid-March of 2020, nu- MILLION Without Borders campaign to benefit merous restaurants, companies, and FOR MELANOMA RESEARCH specific initiatives in research and individuals stepped up to donate food FROM A GRATEFUL PATIENT. care at a variety of institutions. West and other items to healthcare workers has also served as a title sponsor of on the frontlines of the pandemic. the Fox Chase Paws for the Cause Fox Chase received multiple do-

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G44653_FCCC AR 20 Body p1-43 FINAL.indd 40 11/13/20 3:49 PM TRACI’S TRIBE RAISED $52,000 FOR FOX CHASE, EXCEEDING nations of food, personal protective A BIG PART OF THE TRIBE THEIR INITIAL GOAL OF equipment, and personal care items from the community as staff contin- Caroline “Casey” Stone likes to play, $15,000. ued to go above and beyond in caring particularly golf and field hockey. But for patients. when it comes to raising money for “We are overwhelmed by the Fox Chase Cancer Center, the 14-year- tremendous support our faculty and old from Huntington Valley doesn’t 20 women. It was formed in memory staff have received from so many play around. As co-chair of Traci’s of Traci DiStefano, who died in 2019 in our community during this time Tribe, she helped raise over $52,000, at age 49 after facing a rare form of of crisis,” said Richard I. Fisher, MD, exceeding her initial goal of $15,000, ovarian cancer for eight years. president and CEO of Fox Chase. and shows no signs of stopping. Throughout her struggles, DiSte- “In particular, the many food do- Traci’s Tribe, a nonprofit, was fano inspired all around her with a nations and encouraging messages founded by a group of three women, positive attitude and her hope that from local businesses have provided including Casey’s mother Kim, who things would get better. She also a tangible reminder that we are all is a nurse at Fox Chase, and their boasted about her support system, coping together.” children, with the help of another her “tribe.” After DiStefano’s passing,

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Stone wanted to keep her memory alive by starting an inaugural fund- raising event. “I’m so proud of all we’ve done together as Traci’s Tribe,” Stone said. “I think we have worked so hard, and Traci would be so proud of everything we’ve accomplished.”

BOARD OF ASSOCIATES WELCOMES NEW LEADERSHIP

The Board of Associates (BOA) of Fox Chase Cancer Center ushered in fiscal year 2021 by welcoming a new executive board led by president Julia Goplerud, a former 27-year Fox Chase employee who, after retiring in 2014, has continued her association and support as a volunteer. Jill Horne, Fox Chase’s manager of internal com- to support research and patient came a global crisis, faculty, staff, and munications, serves as the new vice care at Fox Chase. The organization community made it an even stronger president. Patricia White continues comprises four member chapters year, Richard I. Fisher, MD, president as BOA treasurer. and one affiliate. Since its founding and CEO of Fox Chase, said at the The BOA is a group of dedicated in 1965, the BOA has raised approxi- Laurel Society President’s Reception volunteers who fundraise year-round mately $26.6 million, and despite the and Annual Donation Meeting for the pandemic, closed out fiscal year 2020 Board of Associates, which was held with a donation of $375,362. online June 18. The BOA is perhaps best known for “There were many occasions to cele- SINCE ITS FOUNDING its Paws for the Cause Dog Walk held brate, including the addition of 10 new IN 1965, THE BOARD each fall. This year, for the first time, clinical and research faculty and the the fundraiser took on a new format well-deserved promotions of 21 faculty OF ASSOCIATES HAS RAISED due to the COVID-19 crisis. Instead of members,” Fisher said. “In addition, APPROXIMATELY gathering for the traditional one-day Fox Chase Cancer Center–Bucking- event, participants took part for the ham marked its 10th anniversary.” $26.6 entire month of October by raising The pandemic made carrying out funds while engaging with their fami- the center’s mission more chal- MILLION lies, friends, and pets from the safety of lenging, but with hard work from AND CLOSED OUT their own homes and neighborhoods. faculty and staff and an outpouring of FISCAL YEAR 2020 community support, Fisher said, Fox Chase continued to deliver world- WITH A LAUREL SOCIETY class cancer care. DONATION OF STATE OF THE CENTER “We are working closely with Tem- . Prior to the COVID-19 pandemic, ple Health to renew our partnership $375,362 Fox Chase had been in the midst of a as we move into the future together,” strong year. When the outbreak be- Fisher added. “Despite the challeng-

42 FOX CHASE CANCER CENTER \ PREVAIL \ ANNUAL REPORT 2020

G44653_FCCC AR 20 Body p1-43 FINAL.indd 42 11/13/20 3:49 PM es, this has been an exciting time in that allowed Kerry Campbell, PhD, to Fox Chase history and the center will bring a clinical urologic oncology fellow AS OF JULY 31, 2020, emerge as strong as ever.” into his lab to explore immunotherapy THE FOLLOWING DONATIONS in relation to renal cell carcinoma. HAD BEEN MADE TO PROTECT But the Leidy’s didn’t stop there. This SURVIVORS’ VIRTUAL year they provided funding to establish AND FEED CENTER STAFF: TAILGATE CELEBRATION a visiting professorship in urologic For the past several summers, it has oncology that will be spearheaded by 50,000 been a beloved Fox Chase tradition Alexander Kutikov, MD. The profes- MASKS, to gather at Citizens Bank Park with sorship pays for one-day visits to take family and friends, enjoy tailgate food place over the next 10 years. The first and drink, take in a Phillies game, visiting professor was Scott Eggener, 400 and celebrate Fox Chase survivors MD, of the University of Chicago, and COOKIES, both on the field and in the stands. the next will be Toni Choueiri, MD, of This year, unfortunately, this group the Dana Farber Cancer Institute. 250 was not able to gather in person due HOAGIES, to the COVID-19 pandemic. But GITLIN FAMILY SURGERY thanks to an engaging online event, WORKROOM OPENS the Virtual Tailgate and Survivors’ 300 Celebration, which was held June 27 In 2019, a new workspace was opened PIZZAS, on Facebook, everyone was together to serve attending physicians, fellows, in spirit. The celebration retained all and residents of Fox Chase. The 60 of its usual joy, hope, and inspiration. Gitlin Family Surgery Workroom CASES OF SNACKS, The event honored Fox Chase was funded by philanthropist Harvey AND survivors and featured uplifting phy- Gitlin in response to a need for a sician messages, engaging exercise collaborative workspace. videos, and an inspiring video from The new space, with badge-only 287 former player and current Phillies access, boasts numerous features, POUNDS OF ambassador Mickey Morandini. Fox including 34 workstations with dual CHOCOLATE CANDY. Chase survivors and their families monitors and an operating-room were the heart of the event, sharing monitor with live patient-surgeon photos and stories as they recounted status. It is located adjacent to the their challenges and triumphs. Marian and Emma Brungard Family Chair in Urologic Oncology. The Fox Chase salutes its survivors and Surgical Waiting Suite, just one level purpose of the chair will be to recruit, their families. They are all true cham- above the operating suite. retain, and reward superior faculty pions who will hopefully be able to get “We’ve found it to be a great place members in urologic oncology who together at the ballpark next year! to coordinate patient care and opti- possess an exemplary record of mize interdepartmental communica- performance in research, surgery, tion,” said Laura McGarry, a resident. teaching, and service. Alexander Ku- VISITING PROFESSORSHIP tikov, MD, FACS, chief of the Division IN UROLOGIC ONCOLOGY of Urology and Urologic Oncology, is ESTABLISHED UROLOGIC ONCOLOGY the inaugural recipient of this newest CHAIR ESTABLISHED After being successfully treated for kid- endowed chair. Kutikov plans to use it ney cancer at Fox Chase in 2009, Tom In appreciation for care provided by to reinforce the clinical and academic Leidy decided to give back to the center Robert G. Uzzo, MD, MBA, FACS, excellence he brings to urologic on- by becoming a donor. In 2015, Leidy Roberta and Ernest Scheller Jr. have cology efforts at Fox Chase. An official and his wife Judy provided funding established the Roberta R. Scheller investiture is being planned.

ANNUAL REPORT 2020 \ PREVAIL \ FOX CHASE CANCER CENTER 43

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\ THE LAUREL SOCIETY \ ADVOCATES’ CIRCLE Bonnie A. & Allen C. Haldeman William H. Lambert $25,000 - $99,999 Jessica M. Kowalchick Cecelia D. & Stanley G. Lane The Laurel Society is the signature Jane M. & Kenneth B. Laffend Gregory G. Lawton donor society of Fox Chase Cancer Anonymous Alexandra G. & Timothy Levin Armand Liffman Center, honoring our most generous Maggie & Bob Beck The Estate of Karlyn Loeb Derek Liu supporters—individuals, corporations, Betty Ann & R. Reginald Bishop Kristin & William Loomis Lisa Kimbro & Ray Lynch foundations, community fundraisers, Kathleen P. & George Blinn Diane S. & Christian F. Martin The Estate of Joan R. C. Lynn and Fox Chase faculty and staff. The Estate of Fay Neil Cressman Beth E. Solomon & John J. Matthews Lee Maniscalco Individual members demonstrate Janet F. & Paul F. Engstrom Joanne Ghanayem Charlene & Nathaniel Mayer their commitment by providing annual Mary R. & Joseph Faulkner & Howard C. McClurd Catherine E. McDevitt support of $1,000 or more during Mickey Faulkner Doreen H. Paynton Kathleen Pitcairn* Fox Chase’s fiscal year (July 1 through Susan G. & Richard I. Fisher Doris B. Salati Eileen & Glenn F. Rall June 30). This list includes gifts in Renee & Neil F. Hall Joyce S. Sando Ellen Rinaldi & Jeffrey B. Sameroff support of In Vino Vita, which was The Estate of Helen Hendrickson Mary Ann Sells & Jonathan Chernoff Patricia F. Rissler & James A. Rogers delayed due to the pandemic. Kay & Thomas W. Hofmann Debra & Leo M. Sniger Krista & Bryan G. Rogers Corporations, foundations, and Makary Hofmann Louise A. Sonnenberg Anne & Stephen C. Rubin community fundraisers become Alice G. & Peter M. Kreindler Marjorie Stanek Jennifer L. & Frank Rupert members at the $5,000+ level. Judith & Thomas K. Leidy S. Brad Tanner Hara & Todd Salkovitz Naomi P. & Philip E. Lippincott Reino Truumees Patricia B. & Harris A. Schwartz \ FOUNDERS’ CIRCLE Sandra G. & David G. Marshall Ellen L. Sherk $500,000 + Salli & Stephen R. Mickelberg \ GUARDIANS’ CIRCLE Jennifer & Erik Streitwieser Nancy & Stephen J. Rauscher $5,000 - $9,999 Elaine W. Sykes Anonymous Robert W. Pettinato Harry Tankin The Estate of Jane P. Charlesworth Robin L. & John C. Spurlino Ellen G. & Michael Araten Robert H. Thurston Barbara R. & Alfonse Gabriele Tania & Robert Stutman Delbert E. Broughton, Jr. Jane & Robert Toll Harvey S. Gitlin & Family Margot Wallace Keith Lizbeth A. & Ed Brunswick Joseph A. Tracy John C. Godfrey & Robert E. Keith, Jr. Christine M. Cardamone Cheryl & Robert G. Uzzo Concetta Greenberg Alfred P. West & William Dauksys Margaret von Mehren & Eric Moss Ann L. & Frank E. Reed Therese M. Carter Maria Werner-Wasik Wendy Trow-Fox & Remy L. Fox \ CHAMPIONS’ CIRCLE Christina S. Chu & Hee Kwon Song & Mariusz A. Wasik The Estate of Miriam Young $10,000 - $24,999 Paula & Jason Della Penna Ruth Weber Lillian & Michael C. DiPiazza Frank C. Wilhelm, Jr. \ CHAIRMEN’S CIRCLE Anne & Grover Albright Alexandra K. Donnelly Karen & Michael A. Young $100,000 - $499,999 Anonymous John Donnelly Jennifer & Matthew Zelesko The Estate of Alice C. Bassett Lori Emrick & Todd J. Glassman Anonymous Michael Bienenfeld Carolyn Y. Fang & John S. Shaw III \ PATRONS’ CIRCLE David B. Campbell Cindy & Jack Bienenfeld Deborah D. Flint $2,500 - $4,999 Carol A. & Louis E. Della Penna, Sr. Nancy E. & Stephen J. Bigelsen Karen A. & Michael D. Flynn The Estate of Clayton H. Downes Lucy S. Binder Diane C. & Cameron H. Fowler Anonymous Julie Ann & Mark Engstrom Claire G. & Bernard A. Borghei Josh Frank The Estate of Margaret D. Barber Susan C. & William J. Federici Regina & Robert J. Brennan Jean A. & G. Wesley Frazier George M. Beschen The Estate of Anna L. Flack Reina S. & Michael A. Cohen Richard E. Greenberg Nicholas Bojda Georgia B. & Richard Koenig Martin Conlon Diane T. & Robert J. Hansberry Dale J. Boychak Lauren & Donald E. Morel, Jr. Elaine M. Daniels Nancy & Kenneth Hellendall Sandi Bryant The Estate of Stanley R. Phelps Helen R. Davis Lynn & Brian Hochberg Elinor & James M. Buck III The Estate of Edward J. Roach Joan M. & John A. Dietze Alice M. Hungerford Mary & John D. Burke Roberta R. & Ernest Scheller, Jr. Helen Dinnocenti Linda G. & Ivan Inerfeld Eileen & Thomas Button The Estate of Jean E. Schlegel Denise M. & Timothy J. Donahue Lisa James Otto & Jonathan E. Otto Devon E. & Todd A. Byers The Estate of Helga Schonholz Elaine T. Emrick Diana Keat & Edward A. Glickman Frances & James Cardea Amy & Joseph A. Frick Colette & Shawn P. Kleitz Paula & Bob Cardea Doris & Arnold Glaberson Cynthia & Warren Kruger Flo & Richard Celender

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G44653_FCCC AR 20 Donors p44-47 FINAL REV1.indd 44 11/10/20 9:28 AM Lili Chen & Charlie Ma Cynthia Reiss-Clark James Bogan Essel D. Dulaimi Al-Saleem Joan R. & Frederick M. Cohen Sheila Ritter Mary Anne Bogie & Furat Al-Saleem The Estate of Tristram C. Colket Janet B. Schell Allison & Barry Boise Sherri & Martin Edelman Veronika DeCrescenzo Kathleen Heaney Ruth C. & Hossein Borghaei Carol Elfant The Estate of Benjamin F. Delong & Kurt A. Schwinghammer Patricia & Ira Born Dawn L. Elliott & Chris Balestrini Margaret & Anthony J. Diasio Thomas Seaman Elizabeth & Hugh Bowerman Diane L. Entrikin Padma & Mohan Doss Elin R. Sigurdson & John A. Ridge Laura & Kerryn Brandt Marjorie G. Ernest Lowell H. Dubrow Donna L. Skerrett Wendy J. & Edward T. Bridgeford Angelica G. & Eugene H. Eshbach Roland L. Dunbrack Cynthia & Howard S. Solganick Terry R. & Alexander J. Brucker Jeff Evans Sally N. Eisenhauer Kristin & Kevin Sterling Ilene & Edward A. Bulanowski Daria & Jeffrey M. Farma Amy C. Fayette Peggy & Brian Strecker Caroline J. & Thomas R. Bunting Ann & James D. Faust Frances L. Finkle The Estate of Henry Stuebner Mary Burns Annette & Lee Favorite Patricia A. & Patrick Gannon Marsha & Barry Taitelman Patricia A.* & Robert C. Busby Rachel J. Finkle & Sven Helmer Tracy M. Gatto Rosalie P. Warren Kathleen A. Butzloff Carol W. & Anthony E. Fiorito Anthony D. Genuardi Christine Laine & David S. Weinberg Donna Lee & Harry E. Cann Judith H. & Stephen D. Flanagan Hilary & Michael D. Glenn Elizabeth & Johnathan Whetstine Therese Carter Rebecca W. Flemer Eileen F. & William A. Goldress Robert L. Winfree Karen A. Cerrato & Marie Lange Amber L. & David C. Flynn Erica A. Golemis & Michael Ochs Yan Wang & Michael Yu Diane & Warren B. Chaiken The Foley Family Julia Goplerud & Arland T. Hotchkiss, Jr. Bernice & Robert P. Chast Richard T. Forchion James Hodgkins \ PARTNERS’ CIRCLE Chiachi Chen Jeffrey H. Forster Marilyn Y. Hosang $1,000 - $2,499 Ida K. Chen Jean & Michael Fowler Athole G. Jacobi Lori & Michael Chewkanes Mark B. Fox Susan E. Johnson & James J. Flynn Patricia Adams Maria Cipollone Robin C. & Robert Fredericks Ruth Kaminer Karen Albright Margie L. Clapper & Donald Carney Margaretha J. & Charles A. Fritz Jessica & Alexander Kutikov Lisa & Stanley J. Altman Andrew J. Cogbill Joseph Fromm Stephen La Neve Linda & Joseph Amorosi Arthur Cohen Dolores K. Fronk Richard F. Lamb Susan J. & Jim Anderson Elizabeth R. & Richard Cohen Sally R. Frost Stephen Laraio Anonymous Jane & Robert Cohen Charles Furst Arnold Levin Althea Aquino Richard D. Colucci Mary L. & Frederick Gallagher Irwin S. Love Gerald F. Arleth Denise C. Connolly & Ronald L. Wolf Lori & Charles Gettis Wendy H. & Solomon C. Luo Suzanne B. Balbirer Doris M. & Nelson B. Cooney Eileen B. Gibbons Ginny Martin Carol & Benjamin Baldridge Fredi & Harry S. Cooper Helena Gisler-Mailey James McDermott Beth Ballentine Geoffrey B. Cox Phyllis S. Gitlin Daniel McGraw Myra & John M. Ballinger, Jr. Diana B. & Michael Daly William R. Goldman Kimberly L. McPhaul Dennis C. Barnes Robert L. D’Avanzo L. Christine Grad John P. Moran Mildred & John R. Barr Janet C. & Aron Davidson Clifton R. Graeff Gordon Morewood Eugene H. Bayard Katherine I. & Dennis N. Davis Marilou & David Greed Kathleen & Francis X. Morris Evelyn M. & Stephen Bennett Antoinette & William DeCarlo Susan J. & Robert Gretz Ruth M. & Preston L. Moyer Judith K. & Arnold M. Bernstein Rose Marie A. Deffenbach Tina Martocello-Gricoski Bridget & Michael D. Mulcahy Virginia T. & Nixon L. Beyer & John McGinley & John J. Gricoski Niven R. Narain Murray Beynon Katherine & Norman Delan Peter A. Grove Patricia S. & Robert S. Nase Suzanne H. & Frank G. Binswanger, Jr. Joy A. & John De Luca Rose Mary & William Gruccio Lillian M. O’Connor Frank Bizzari Crystal S. Denlinger Cecily J. Sawyer-Harmon Rosaleen & Rick Parsons Nellie C. Blackwell Marie DeRatto & Alan R. Offermann Lynn Martin Haskin & Donald L. Haskin Irma E. Peoples Richard J. Bleicher Brian W. Derbyshire Charles L. Heaton Tina M. Pidgeon Linda C. & James Bluebello Susanne L. & Joseph DiBianca Anne D. & David Heiser & Timothy H. Fitzpatrick Jason Blusius Martin J. Dolan Alice C. Hennessy Margo B. & Daniel Polett Theodore T. Bobroski Michael T. Donnelly Marie T. & Adam Hepp Kim L. Rainey-Nichols Theresa & Richard M. Bobroski Tobe I. Dresner Carla & Enrique Hernandez & Scott J. Nichols Kathleen & Anthony Boccella Dorothy S. Dryburgh Evelyn & Michael Hernandez Ellen & Peter L. Reiss Caroline & Joseph Bodnik Allison & Michael G. Dubrow Mary Hile Herold

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John E. Hessenthaler Arlene L. Miller Josephine C. Sha CORPORATIONS, FOUNDATIONS Ellen Hollin James W. Miller Kathryn Shively McKissock & ORGANIZATIONS Debra & Ronald Horrell Keiko & George L. Miller & J. Bruce McKissock Judith Chasin & Eric M. Horwitz Suzanne Miller & Isaak Halegoua Keiko & John R. Simon \ LEADERS’ CIRCLE Irmatraud R. Hotz Richard B. Millham Anna Marie & Rudolph Skalka $20,000 + Kenneth A. Hullings Diane & Martin Mozzo Renee Skeels Linda & James L. Hunsicker Claire & Thomas J. Mulvaney Jeff M. Snider American Brain Tumor Association Barbara T. & Kevin Ilsen John G. Nalesnik Shirley D. & D. Glenn Snyder American Cancer Society Anne E. & John Jadwin Alice & Stephen Obarski Elsie L. Spiro American Lung Association Archie J. Jenkins Barbara J. O’Donnell Rachel L. Springer The Benevity Community Impact Fund Mary M. Jones Katherine A. Odorow-Portnoy Staci & Jonathan Steinfeld Board of Associates of Fox Chase Aarti & Yuwaraj Kadariya & Alan Portnoy Kari-Leigh Steinhagen Cancer Center Carolyn G. & Michael W. Keefe Ephe A. Olliver Janice A. Stilley • Bucks County Chapter Mary E. Kelbaugh Deena J. & Brian O’Neill Shirley E. & John E. Stoddard, III • Marlyn Fein Chapter James P. Kilkenny Roseann & Robert Opdyke Craig Sullivan • Friends of Fox Chase Cancer Center Marian W. & Walter C. Kinzinger Laura M. Owens Nancy L. & Raymond J. Svitak • Jimbo’s Squad Nicole T. & Kenneth Klein Heidi & Scot D. Pannepacker Pauline & Michael J. Sweeney • Main Line Chapter Kristin & Brian Kozera Nicholas Panos Andrea Taitelman • Young Professionals Chapter Nancy L. Kulp Catherine & Salvatore S. Paone Priscilla & Joseph R. Testa Bristol-Myers Squibb Company, George A. Kummeth Mara E. Parker Jacqueline G. & Frederick P. Thomas Worldwide Medicines Nancy C. La Roche Aris Pasles James A. Tobin Christina Matthes Trust U/W Jeannine & James Lajeunesse Christine & Sameer A. Patel Elizabeth L. & Stephen J. Tolkach Christopher M. Fuga Memorial Fund Jennifer V. & Noel C. Langlois Pradeep R. Patel Sheri B. & Neal S. Topham CRDF Global Anna Maria Larenz Richard E. Patton Kathleen A. Torano David Foundation Mary Ellen & Kenneth W. Lee Patricia A. & Thomas W. Peddie Amanda Toska Eli Lilly Company Bernadette Leibensperger Jane G. Pepper Felicia R. Toska The Fund for Charitable Giving Laura & Daniel S. Levin Elaine & Stephen A. Perkins Dorothy M. & Edward Tosti, Jr. GIST Cancer Research Fund Sarah J. Levine Elizabeth R. & David J. Plimack Louise & Thomas R. Tritton The Harvey S. Gitlin Family Foundation Michael Lieberman Denise H. & Jeffrey H. Portner Winifred L. & Norman Troxel Henry and Helen Bienenfeld LaTonya & Arden L. Liverman Margaret E. & Anthony C. Pratt Catherine Tuite & Eric Rosenberg Foundation Rochelle M. & Charles Lobel Valerie & Robert A. Price Elizabeth P. Ulmer Insulators & Allied Workers' Local 14 Linda G. London Tony Reed Julie M. Van Campen Mesothelioma Fund Natalie Lotier Jessica & Marc Reider Bradley S. Van Schooneveld Insulators Local 24 James E. Mackin Henry Z. Renelli Marilyn F. & Daniel F. Veber Joseph & Mary Faulkner Family Amy B. MacLean Janice & Charles Riley Janine C. & Massimo Verduci Foundation Gregory Magee The Ritchie Family Eric Vogel Kansas University Endowment Vincent Maisano Elizabeth & Brian Rizor Joseph Vu Association Angeline & Gerald J. Manna Nancy & Brian D. Robinson Maryanne Walsh Kicking Cancer Foundation Brande Mark & Frank Falzett Richard C. Roden Elizabeth & Robert Watts Edwin M. Lavino Foundation James W. Masterson Fereshteh & Heinrich Roder Miriam & Homer Weaver Lisa’s Army Catherine F. McDevitt-Mock Lucyann M. & John J. Roley, Sr. Katherine H. & Timothy J. Weber Lung Cancer Research Foundation Christine A. & William McDonnell Eric Rolin Stephanie Weiss & Hugh Mclaughlin Lutron Foundation Elizabeth Mcgettigan Shari & Mark Rosenberg Beatrice & Richard Wernick The McGrorty Foundation Inc. Sandy & William J. McMahon Jill S. & Norman G. Rosenblum Brooke & Tracey Williams Melanoma Research Alliance David R. McShane Deborah K. & David E. Ross Shelley Wolf Harris & Steven Harris Olga Steinhulber Charitable Anna T. Meadows & Alfred G.* Knudson, Jr. Jesse Ruth Anthony J. Wong Remainder Unitrust Nancy J. Medlar William J. Ryan Hong Wu Ovarian Cancer Research Fund Alliance Dorothy & John E. Meggitt Marie J. Saxton M. Curtis Young Peggy’s Pathway for Women’s Liz & Jonathan Meister Tina Schechter Zexun Zhou Cancer Care Susan & Hal Michels Marilyn & Alan C. Schwedel Susan S. Zuccotti PHL COVID-19 FUND Barton N. Milestone Jean M. Seibel Ervin Zucker Reimann Fellowship Fund

46 FOX CHASE CANCER CENTER \ PREVAIL \ ANNUAL REPORT 2020

G44653_FCCC AR 20 Donors p44-47 FINAL REV1.indd 46 11/10/20 9:28 AM Sandy Rollman Ovarian Cancer Harmelin Media James M. Beard Nancy & M. Michael Markowich Foundation The Harry and Jeanette Weinberg Toni-Lee Beigel Richard B. Millham, Sr. Sarcoma Foundation of America Inc. Foundation Incorporated John C. Bennett Cathie M. Minehart Scholl’s Wellness Co. Haymarket Media Inc. Catherine & Walter G. Bittner Evalind Minor Susan G. Komen for the Incyte Corporation Kathleen P. & George R. Blinn Beatrice Mintz Cure Philadelphia Instahub Raphaela Blum Judith A. & James F. Mitchell III Tanner Industries Inc. Insulators Local 23 Kay & Mike Breuninger Diane & David M. Morgan Temple University Health System Insulators Local 32 Kathleen Bullano Michael J. Nauss Theresa Fresco Charitable Isabella P. Spratt Fund Patricia A.* & Robert C. Busby Elma Neeld Remainder Annuity Trust John Kennedy Dealerships Margaret A. & Thomas A. Coughlin Diane W. Nyland Thomas Jefferson University Johnson & Johnson Robert J. Cronk John E. Orban III Traci’s Tribe Kite Pharma Inc. Maureen E. & J. Russell* Cullen, Jr. Kaye & Merrill D. Paletz United Way of Greater Philadelphia LAOH Brigid McCrory Division 25 Elizabeth & John Dambrowski Sandra L. Paugh and Southern New Jersey The Lenore & Howard Klein Foundation Emily M. Dannaker* Wenona & Raymond A. Paul, Jr. Univest Foundation The Marianne DiNofrio Pancreatic Helen R. Davis Sally Peirson The W. M. Keck Foundation Research Foundation Nancy S. Day Jane G. Pepper The W. W. Smith Charitable Trust The Morris S. & Florence H. Bender Carol A. & Louis E. Della Penna, Sr. Beatrice C. Pilch Warren Alpert Foundation Foundation Linda & Robert Devlin Irma S. Platnick Wawa Foundation New York/New England States Arline L.* & Ira R. Dolich Clare K. Porac West Pharmaceutical Services Inc. Conference of Insulators Sondra Doner Joanne & Alexander Rankin Worldwide Cancer Research Novartis Pharmaceuticals Corporation Kendra B. Eager Ann L. & Frank E. Reed Wright-Cook Foundation Oscar H. & E. Ida Iucker Yvonne Eldridge Joseph P. Rees YourCause, LLC Trustee Memorial Fund Carol Elfant Richard C. Roden OUR United Corporation Barbara R. & Alfonse J. Gabriele Dominic Romagano \ FRIENDS’ CIRCLE Out of the Blue Productions Helen J. Gebhardt Jayne H. & Paul I. Rosen $5,000 - $19,999 Pfizer Inc. Catherine R. Getchell John Ruggio Phillies Charities Inc. Nancy E. Goldy Daphne B. Sawyer AHEPA Cancer Research Rita R. Holman Breast Cancer Concetta Greenberg Cecily J. Sawyer-Harmon Foundation, Fifth District Foundation Inc. Elizabeth Kapnek Grenald Carol Schramek Amgen Inc. Sanofi oundationF for North America Edith D. & Frank M. Highley, Jr. Karen Schwartz Bank of America Employee Schultz & Williams Lois Hitchman Josephine Scully Giving Campaign Society Hill Anesthesia Consultants PC Jane E. Hollenbach Lia M. Skillern & Theodore S. Dalstrom Berg LLC Ukrainian American Sports Center Alice M. Hungerford Barbara L. Sparks Broughton Foundation The V Foundation for Cancer Research David P. Ineich Zuzanna L. Stankay Byers Choice Ltd. Vertical Bridge REIT LLC Nancy & Rodney D. Johnson Bonnie Stock C. F. Martin & Co. The Walter Henry Freygang Foundation Joan E. Jones Nancy K. Switzer C.W.A. Local 13000 Wine Hard Breathe Easy Mary Ann Jones Norma Tither Caris Life Sciences WIRB-Copernicus Group Inc. Barbara R. & Charles Kahn, Jr. Wendy B. Trow-Fox Carve for Cancer Inc. Edwin S. Kalman & Remy L. Fox Daiichi Sankyo Inc. \ ELIZABETH ANDERSON SOCIETY Gwendolyn S. & Colbert I. King Adele E. Veihl The Daniels Foundation Janet C. Kistner Anna Vinerova Digital Science Press Inc. The Elizabeth Anderson Society honors Beth K. Kocher-Ferraro & Frank Ferraro Margot Wallace Keith Duane Morris LLP thoughtful friends of Fox Chase who Richard Koenig & Robert E. Keith, Jr. Eisai Inc. have established gifts in the form Janet B. Kovacs Norman F. Watts* Envigo RMS of a bequest, gift annuity, charitable Geraldine M. Kozempel Sandra W. & Timothy C. Weckesser Exelon Foundation remainder trust, charitable lead Martha J. & R. Donald Leedy Naomi Weiss Flatiron Health Inc. trust, life insurance policy, retirement Michael Levin Justin L. Young Foundation Medicine account, or select gifts of real estate. Wendy & Andrew L. Lewis IV Joyce C. Zimmerman Genentech Inc. Naomi P. & Philip E. Lippincott Genomic Health Inc. Anonymous Susan & William G. Little *Deceased GlaxoSmithKline Suzanne Balbirer Angela M. Lynch

ANNUAL REPORT 2020 \ PREVAIL \ FOX CHASE CANCER CENTER 47

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\ 2020 BY THE NUMBERS \ \ PHILANTHROPY SNAPSHOT \ \ VOLUNTEER SNAPSHOT \ 644 $17,169,272 401 SCIENTIFIC PUBLICATIONS TOTAL PHILANTHROPIC SUPPORT VOLUNTEERS 119,836 $700,000 69,583 OUTPATIENT VISITS RAISED AT IN VINO VITA TOTAL VOLUNTEER HOURS 6,738 11,038 $226,573 NEW PATIENTS TOTAL DONORS VOLUNTEER DEPARTMENT BUDGET 17 3,842 $1,769,496 NEW FACULTY MEMBERS TOTAL NEW DONORS VALUE OF HOURS* 605 $1,542,923 CURRENT DONORS WHO HAVE NET VALUE ADDED TO FOX CHASE GIVEN 30+ YEARS *Based upon the independent sector value of $25.43/hr. $375,362 BOARD OF ASSOCIATES TOTAL GIFTS

287ACTIVELY ENROLLING CLINICAL INVESTIGATOR87 INITIATED CLINICAL RESEARCH STUDIES RESEARCH STUDIES

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G44653_FCCC AR 20 Financials p48-51 FINAL.indd 48 11/10/20 9:28 AM \ CLINICAL SNAPSHOT \ (In Thousands) FY20

REVENUES — CLINICAL ACTIVITY PATIENT CARE REVENUE — HOSPITAL $400,373 PATIENT CARE REVENUE — PHYSICIANS $31,741 PHILANTHROPY, OUTREACH & OTHER $17,498 CLINICAL REVENUE $449,612

OPERATING EXPENSES — CLINICAL ACTIVITY DIRECT PATIENT CARE $341,889 SUPPORT SERVICES $19,134 ADMINISTRATIVE & GENERAL $67,111 CAPITAL RELATED COSTS $7,903 MAINTENANCE & PLANT OPERATIONS $12,379 CLINICAL EXPENSES $448,416

KEY PATIENT CARE STATISTICS NEW PATIENTS 6,738 HOSPITAL ADMISSIONS 3,384 CHEMOTHERAPY INFUSIONS & RELATED PROCEDURES 62,883 RADIATION THERAPY TREATMENTS 28,002 SURGICAL PROCEDURES 4,477

\ RESEARCH SNAPSHOT \

ACTIVE FUNDED PROJECTS FUNDING SOURCE NUMBER OF PROJECTS DIRECT COSTS TOTAL COSTS

PEER-REVIEWED NCI 69 $11,892,538 $19,826,988 OTHER NIH 56 $10,890,316 $16,956,850 OTHER 34 $4,398,492 $6,242,080 SUBTOTAL OF PEER-REVIEWED 159 $27,181,346 $43,025,918

NON PEER-REVIEWED INDUSTRY 58 $5,386,042 $7,029,815 OTHER NON PEER-REVIEWED 43 $3,213,619 $3,788,246 SUBTOTAL OF NON PEER-REVIEWED 101 $8,599,661 $10,818,061

GRAND TOTAL 260 $35,781,007 $53,843,979

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\ TYPES OF CANCER TREATED \

1% 2% 3% LYMPHOMA HEAD & NECK PANCREAS

5% 5% 7% COLORECTAL BLADDER KIDNEY

7% 9% 10% SKIN GYNECOLOGICAL LUNG

15% 18% 15% BREAST PROSTATE OTHER

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COMMERCIAL 40%

MEDICARE 36%

MEDICARE MANAGED CARE 15 %

MEDICAID 8%

SELF PAY/OTHER 1%

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G44653_FCCC AR 20 Financials p48-51 FINAL.indd 51 11/10/20 9:28 AM LEADERSHIP & FACULTY

\ SENIOR ADMINISTRATORS David G. Marshall THE GLORIA & EDMUND M. DUNN ROBERTA R. SCHELLER Christopher W. McNichol CHAIR IN THORACIC ONCOLOGY CHAIR IN UROLOGIC ONCOLOGY Richard I. Fisher, MD Donald E. Morel Jr., PhD Hossein Borghaei, DO, MS Alexander Kutikov, MD, FACS President & Chief Executive Officer Leon O. Moulder Jr. Chief, Division of Thoracic Medical Chief, Division of Urology and Cancer Center Director John A. Ridge, MD Oncology Urologic Oncology Senior Associate Dean, Donna L. Skerrett, MD Lewis Katz School of Medicine MARVIN S. GREENBERG, MD JACK SCHULTZ at Temple University \ FOX CHASE CANCER CENTER CHAIR IN PANCREATIC CANCER SURGERY CHAIR IN BASIC SCIENCE FOUNDATION BOARD OF John P. Hoffman, MD, FACS Johnathan R. Whetstine, PhD J. Robert Beck, MD DIRECTORS Chief, Pancreaticobiliary Service Leader, Cancer Epigenetics Program Deputy Director Special Assistant to the CHAIR: Donald E. Morel Jr., PhD PAUL GROTZINGER & WILBUR RAAB WILLIAM WIKOFF SMITH President for Academic and VICE CHAIR: Louis E. Della Penna Sr. CHAIR IN SURGICAL ONCOLOGY CHAIR IN CANCER RESEARCH Professional Affairs Ira R. Dolich Stephen C. Rubin, MD Erica Golemis, PhD William J. Federici Chief, Division of Gynecologic Oncology Deputy Chief Scientific Officer Jonathan Chernoff, MD, PhD Richard I. Fisher, MD Deputy Director Edward A. Glickman SAMUEL M.V. HAMILTON TIMOTHY R. TALBOT JR. Chief Scientific Officer Lewis F. Gould Jr. CHAIR IN CANCER PREVENTION CHAIR IN CANCER RESEARCH Thomas W. Hofmann Margie L. Clapper, PhD Mary B. Daly, MD, PhD, FACP Glenn F. Rall, PhD Barbara Ilsen Deputy Chief Scientific Officer Chair Emerita, Department of Chief Academic Officer Margot Wallace Keith Clinical Genetics Geoffrey Kent GERALD E. HANKS Judith L. Bachman, RN, BSN Dan Levin CHAIR IN RADIATION ONCOLOGY CAROL & KENNETH WEG Chief Operating Officer Philip E. Lippincott Eric M. Horwitz, MD, FABS, FASTRO CHAIR IN HUMAN GENETICS Solomon C. Luo, MD Chair, Department of Radiation Joseph R. Testa, PhD, FACMG Ray Lynch, CPA, MBA David G. Marshall Oncology Co-Leader, Cancer Biology Program Chief Financial Officer Lindy Snider Thomas R. Tritton, PhD THE DONALD E. & SHIRLEY C. MOREL, H.O. WEST & J.R. WIKE James Helstrom, MD, MBA STANLEY & STELLA BAYSTER CHAIR IN CANCER RESEARCH Chief Medical Officer \ FOX CHASE CANCER CENTER CHAIR IN MOLECULAR DIAGNOSTICS J. Robert Beck, MD ENDOWED CHAIRS Mariusz A. Wasik, MD Senior Vice President & Deputy Director Anne Jadwin, RN, MSN Chair, Department of Pathology Chief Nursing Officer LOUIS DELLA PENNA FAMILY ROBERT C. YOUNG, MD CHAIR IN HEAD & NECK ONCOLOGY G. WILLING “WING” PEPPER CHAIR IN CANCER RESEARCH Shawn Kleitz Drew Ridge, MD, PhD, FACS CHAIR IN CANCER RESEARCH Richard I. Fisher, MD Chief Development Officer Chief, Head and Neck Surgery Robert G. Uzzo, MD, FACS President & Chief Executive Officer Chair, Department of Surgical \ BOARD OF DIRECTORS CAROL & LOUIS DELLA PENNA Oncology \ CLINICAL FACULTY CHAIR IN UROLOGIC ONCOLOGY CHAIR: Lewis F. Gould Jr. Richard E. Greenberg, MD, FACS STANLEY P. REIMANN DEPARTMENT OF BONE MARROW John M. Daly, MD Professor, Department of CHAIR IN ONCOLOGY RESEARCH TRANSPLANT AND CELLULAR THERAPIES Ronald R. Donatucci Surgical Oncology Jonathan Chernoff, MD, PhD CHAIR: Henry Fung, MD William J. Federici Chief Scientific Officer Rashmi Khanal, MD Edward A. Glickman G. MORRIS DORRANCE JR. Michael Jay Styler, MD 2 Kimberly D. Hagerich CHAIR IN MEDICAL ONCOLOGY AUDREY WEG SCHAUS Asya Varshavsky-Yanovsky, MD, PhD Sandra Harmon-Weiss, MD Martin J. Edelman, MD & GEOFFREY ALAN WEG Thomas W. Hofmann Chair, Department of Hematology/ CHAIR IN MEDICAL SCIENCE DEPARTMENT OF CLINICAL GENETICS Larry R. Kaiser, MD Oncology David S. Weinberg, MD, MSc CHAIR: Michael J. Hall, MD, MS Margot Wallace Keith Chair, Department of Medicine Mary B. Daly, MD, PhD Robert H. LeFever Elias Obeid, MD, MPH Solomon C. Luo, MD Kristen Whitaker, MD

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G44653_FCCC AR 20 L&F p52-54 FINAL.indd 52 11/13/20 3:55 PM DEPARTMENT OF DIAGNOSTIC James Martin, MD PSYCHIATRY Richard Bleicher, MD IMAGING Anthony J. Olszanski, MD Emmie Chen, MD Marcia Boraas, MD CHAIR: Rosaleen Parsons, MD Elizabeth Plimack, MD 1 Suzanne Doubrava, MD David Chen, MD Andrea Abbott, MD Emmanuel Quinn, MD Paula Finestone, PhD Christina Chu, MD Sarah Abdulla, MD 4 Iberia Romina Sosa, MD, PhD PULMONARY MEDICINE Andres Correa, MD 2 Omar Agosto, MD 4 Joseph Treat, MD Sheela Ahmed, MD 2 Paul Curcillo, MD Jordan Anaokar, MD 1 Namrata Vijayvergia, MD Alan Haber, MD John Michael Daly, MD Meghan Boros, MD Margaret von Mehren, MD Rohit Kumar, MD Jeffrey Farma, MD 1 Mark Burshteyn, MD 4 Jennifer Winn, MD Christopher Manley, MD Stephanie Greco, MD Thomas Chayapruks, MD 4 Matthew Zibelman, MD Julio Noriega, MD Richard E. Greenberg, MD Gary Cohen, MD 4 PAIN AND PALLIATIVE CARE Stephanie King, MD Emily Cuthbertson, MD 4 Marcin Chwistek, MD DEPARTMENT OF PATHOLOGY Alexander Kutikov, MD Sarah Fenerty, MD 4 Molly Collins, MD CHAIR: Mariusz Wasik, MD Miriam Lango, MD Claudia Kasales, MD 2 Dylan Sherry, MD 2 Tahseen I. Al-Saleem, MD Jeffrey Liu, MD Mansoor Khan, MD 4 J. Robert Beck, MD Gina Mantia-Smaldone, MD 1 Shane Lee, MD 4 \ FOX CHASE CANCER CENTER Harry S. Cooper, MD Sameer Patel, MD Laura Levin, MD AT TEMPLE UNIVERSITY Hormoz Ehya, MD Sanjay Reddy, MD 1 Yi Li, MD HOSPITAL Douglas Flieder, MD Drew Ridge, MD, PhD Aaron Losey, MD 4 Yulan Gong, MD Stephen Rubin, MD Barton Milestone, MD Juhi Mittal, MD Min Huang, MD Cecelia Schmalbach, MD, MSc Dmitry Niman, MD 4 Aruna Padmanabhan, MD Nicholas Mackrides, MD M. Shuja Shafqat, MD Joseph Panaro, MD 4 Alvaro Pereira-Rico, MD Rajeswari Nagarathinam, MD Elin Sigurdson, MD, PhD Pratik Patel, DO 4 Deric Savior, MD Reza Nejati, MD Marc Smaldone, MD David Pryluck, MD 4 Arthur S. Patchefsky, MD Ahmed Soliman, MD Varun Sethi, MD 4 DEPARTMENT OF MEDICINE Y. Lynn Wang, MD, PhD Stacey Su, MD Jeremy Sykes, MD 4 CHAIR: David S. Weinberg, MD Shuanzeng Wei, MD, PhD Neal Topham, MD Catherine Tuite, MD CARDIOLOGY Hong Wu, MD, PhD Rosalia Viterbo, MD Jian Qin Yu, MD Steven Mattleman, MD ANESTHESIOLOGY DERMATOLOGY DEPARTMENT OF RADIATION James L. Helstrom, MD 1 DEPARTMENT OF HEMATOLOGY/ Abhishek Aphale, MD ONCOLOGY Kristen K.G. Krauss, MD ONCOLOGY Anthony Santoro, MD CHAIR: Eric M. Horwitz, MD Scott Levin, MD CHAIR: Martin J. Edelman, MD ENDOCRINOLOGY Penny Anderson, MD Michelle McMaster, MD Fern Anari, MD Christian Koch, MD, PhD 2 Jo Ann Chalal, MD Gupreet Mundi, MD Igor Astsaturov, MD, PhD Pankaj Sharda, MD Randi Cohen, MD, MS Vaishali Naik, MD Jessica Bauman, MD GASTROENTEROLOGY Thomas Galloway, MD Dmitry Roberman, DO Hossein Borghaei, DO Michael Bartel, MD Mark Hallman, MD Felipe Suero, MD Jonathan Cheng, MD Jennifer Higa, MD Shelly Hayes, MD Crystal Denlinger, MD Minhhuyen Nguyen, MD Krisha Howell, MD \ RESEARCH FACULTY Efrat Dotan, MD Jeffrey Tokar, MD Sameera Kumar, MD Scot Ebbinghaus, MD HOSPITALISTS Joshua Meyer, MD BLOOD CELL DEVELOPMENT Richard I. Fisher, MD Usman Ali, MD Mark Sobczak, MD & FUNCTION Vijaykumar Gandhi, MD Daniel Holleran, MD Sangeeta Tyerech, MD PROGRAM LEADERS Daniel Geynisman, MD Kyungsuk Jung, MD Stephanie Weiss, MD Siddharth Balachandran, PhD Pooja Ghatalia, MD Kristen Manley, MD 1 David L. Wiest, PhD Anshu Giri, MD, MS Kenneth Patrick, MD DEPARTMENT OF SURGICAL PRIMARY MEMBERS Lori J. Goldstein, MD Rajkumar Sarkar, MD ONCOLOGY Kerry S. Campbell, PhD Jason Incorvati, MD Krishnalatha Sreekrishnanilayam CHAIR: Robert G. Uzzo, MD Richard I. Fisher, MD 3 Angela Jain, MD Devakiamma, MD Abbas El-Sayed Abbas, MD Henry Fung, MD 3 Rishi Jain, MD, MS Hayley Walker, MD John Abraham, MD Stefania Gallucci, MD 4 Nadia Khan, MD PHYSICAL MEDICINE & REHABILITATION Allison Aggon, DO Kyoko Hayakawa, MD, PhD Gregory Lubinieki, MD Gilbert Lafontant, MD Cynthia Bergman, MD 1 Dietmar J. Kappes, PhD

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Dan A. Liebermann, PhD 4 Lori J. Goldstein, MD 3 Elias Obeid, MD 3 The Annual Report is produced by the Xuebin Qin, MD, PhD 4 Eric Horwitz, MD 3 Camille Ragin, PhD 1 Communications Department of Fox Chase Glenn Rall, PhD Eileen K. Jaffe, PhD Jennifer Reese, PhD Cancer Center. Contact us at [email protected]. Christoph Seeger, PhD Neil Johnson, PhD Eric Ross, PhD, ScM 1 4 Temple Health refers to the health, education Anna M. Skalka, PhD John Karanicolas, PhD Laura Siminoff, PhD and research activities carried out by the 4 4 3 Tomasz Skorski, MD, PhD Kamel Khalili, PhD David S. Weinberg, MD affiliates of Temple University Health Jonathan Soboloff, PhD 4 Nadia Khan, MD Kuang-Yi Wen, PhD System (TUHS) and by The Lewis Katz School Stephen M. Sykes, PhD Michael L. Klein, PhD 4 Temple University School of Medicine. TUHS Maurisz Wasik, MD Ronald Levy, PhD 4 CANCER EPIGENETICS neither provides nor controls the provision Yibin Yang, PhD Jeffrey C. Liu, MD 4 PROGRAM LEADERS of health care. All health care is provided by its member organizations or independent Raza M. Zaidi, PhD 4 Salim Merali, PhD 4 Vasily M. Studitsky, PhD health care providers affiliated with TUHS 3 Matthew Zibelman, MD Joshua Meyer, MD Johnathan R. Whetstine, PhD member organizations. Each TUHS member 3 Anthony J. Olszanski, MD PRIMARY MEMBERS organization is owned and operated pursuant CANCER BIOLOGY Alana O’Reilly, PhD Andrew J. Andrews, PhD to its governing documents. PROGRAM LEADERS John A. Ridge, MD, PhD 3 Alfonso Bellacosa, MD, PhD Jonathan Chernoff, MD, PhD Lori Rink, PhD Nora Engel, PhD 4 Jeremy Moore Joseph R. Testa, PhD Heinrich Roder, PhD Jian Huang, MD, PhD 4 Senior Director of Communications PRIMARY MEMBERS Elin R. Sigurdson, MD, PhD 3 Jaroslav Jelinek, MD, PhD 4 Patrick McGee Joan-Font Burgada, PhD Vincent A. Voelz, PhD 4 Richard A. Katz, PhD Publications Manager Edna Cukierman, PhD Margaret von Mehren, MD 3 Elizabeth R. Plimack, MD, MS 3 4 Sarah Hughes Paul Campbell, PhD Ross Wang, PhD Carmen Sapienza, PhD Editorial Assistant James S. Duncan, PhD Ho-Lun Wong, PhD 4 Bassel E. Sawaya, PhD 4 Bojana Gligorijevic, PhD 4 Jinhua Wu, PhD Italo Tempera, PhD 4 Marian Dennis Jennifer Gordon, PhD 4 Michael Yu, MD 3 Hong Wang, MD, PhD 4 Staff Writer Xavier Graña, PhD 4 Yi Zhang, MD, PhD 4 Writers & Contributors Raymond Habas, PhD 4 CANCER PREVENTION Jill Horne Andres J.P. Klein-Szanto, MD, PhD & CONTROL 1 Newly promoted faculty at Marian Dennis Vladimir Kolenko, MD, PhD PROGRAM LEADERS Fox Chase Cancer Center Sarah Hughes Warren D. Kruger, PhD Margie L. Clapper, PhD 2 Newly recruited faculty at Design Jeffrey R. Peterson, PhD Carolyn Y. Fang, PhD Fox Chase Cancer Center B&G Design Studios Richard T. Pomerantz, PhD 4 PRIMARY MEMBERS 3 Member of the Fox Chase Cancer Jose Russo, PhD Nezar Al-Hebshi, PhD 4 Center clinical faculty Photography Kelly Whelan, PhD 4 Sanjeevani Arora, PhD 4 Faculty based at Temple University Colin Lenton Hong Yan, PhD J. Robert Beck, MD Printing Zeng-jie Yang, MD, PhD Wen-Chi Chang, PhD Brilliant Graphics Timothy J. Yen, PhD Bradley N. Collins, PhD 4 Mary B. Daly, MD, PhD 3 Connect with us online! MOLECULAR THERAPEUTICS Efrat Dotan, MD 4 Visit annualreport.foxchase.org PROGRAM LEADER Paul F. Engstrom, MD 3 Erica A. Golemis, PhD Susan Gross Fisher, PhD 4 PRIMARY MEMBERS Ana M. Gamero, PhD 4 Philip Abbosh, MD, PhD Daniel Geynisman, MD 3 Rodrigo Andrade, PhD 4 Sergei Grivennikov, PhD Mark Andrake, PhD Michael J. Hall, MD 1, 4 Igor Astsaturov, MD, PhD 3 Elizabeth Handorf, PhD 1 Comprehensive Hossein Borghaei, DO 3 Enrique Hernandez, MD 3 Cancer Center A Cancer Center Designated by the Denise C. Connolly, PhD Resa James, MPH, PhD 4 National Cancer Institute Roland L. Dunbrack Jr., PhD Stephen Lapore, PhD 4

Martin J. Edelman, MD Shannon Lynch, PhD, MPH PHILADELPHIA MAGAZINE’S Brian L. Egleston, PhD Grace X. Ma, PhD 4 Margret Einarson, PhD 1 Suzanne M. Miller, PhD 2019

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