Subject Index

acanthosis 78, 218, 229, 352 – aeroallergens 59 – fumigatus 418 Acarus siro var. hominis 123 – contact allergens 58 astemizole 497 acid ceramidase 161 – food allergens 58 asthma, see also bronchial asthma 4, acidic syndet 474 alloknesis 223 108, 151, 152, 246, 391 acquired immunodeficiency syndrome alopecia areata 131 –inadults111 (AIDS) 202 alpha-hemolysin 407 – in children 111 acrodermatitis enteropathica 104 alpha-pinene 385 – risk factors 109 activation-induced T cell death Alternaria 396 asthmatic wheezing 434 (AICD) 326 amino acid 479 ataxia teleangiectatica 209 activator protein 332 – exchange 258 atopic – 1 (AP-1) 336 – sequence 340 –airwaydisease511 acupuncture 586, 592 –solution54 – dermatitis adenosintriphosphate 530 amphiphilic emulsion 464 – – descendant family history 215 adhesin 406 amyloidosis 133 ––maternaleffect 215 adrenal cortical hormone 477, 488 anaphylaxis 3 – – paternal effect 215 aeroallergen 54, 59, 296, 299, 395, angiotensin-converting enzyme 307 – eczema 443, 507, 513 anhidrotic congenital ectodermal dys- ––afterchildhood 150 agglutination test 407 plasia (ACED) 129 ––asthma 151 aggravating factors 57 animal model 261, 410 – – climate 507 aggression 548 ankylosing spondylitis 146 – – community samples 150 AIDS 123, 202 anorexia nervosa 162 – – comorbidity 545 air antecubital eczema 38 – – diagnostic criteria 21, 90 – pollen concentration 512 antibacterial – – differential diagnosis 95, 100 – pollution 27, 507, 513 – silver coated textile 496 – – discoid variant 87 airway – therapy 599 ––eczematousskin 218 – eosinophilia 110 anticyclones 511 – – extrinsic/intrinsic subtypes 24 – hyperresponsiveness (AHR) 325, antigen ––familyhistory 213 346 – antigen-presenting cell (APC) 208, – – follicular form 80, 81 alkaline 473 218, 265, 269, 282 – – follicular variant 86 allergen 332 – exposure 450 ––frequencyinadults 22 – allergen-specific immunothera- – uptake 266 – – frequency in children 22 py 438 antihistamine 110, 153, 226, 272, 598 ––hayfever 151 – exposure 435 anti-inflammatory drug 459 ––inchildhood 86 – sensitization 153 anti-ovalbumin 387 ––intrinsictype 154 allergic antipruritics 226 – – intrinsic/non-IgE-associated – asthma 230 antiseptics 495, 599 type 81 – conjunctivitis 125 anti-staphylococcal therapy 493 – – irritant exposure 171 – contact dermatitis (ACD) 168, 178, anxiety 32, 545, 548, 552 ––nummulartype 87 484 apolar emulsion 463 – – occupational guidelines 175 – inflammation, apoptosis 326 apoptosis 326, 421 – – papular lichenoid variant 86, 87 – rhinoconjunctivitis, see also hay apron sign 167 ––papuloustype 37 fever 4, 230, 434 Arabidopsis thaliana 420 – – parental predisposition 24 –shiners68 aristolochic acid 592 ––phases 228 – tissue inflammation 281 aroma therapy 587 ––pollen-sensitive 24 allergy testing 58 Aspergillus 396 ––prevalence 22 606 Subject Index

––prevention 552,601 birch pollen allergy 403, 418 chlorine 528 ––prognosticfactors 27 – birch-pollen-related food 402 chlorpheniramine 503 – – prurigo type 87 blepharoconjunctivitis 125 cholesterol 458 ––riskfactors 24 blood eosinophilia 109, 313 –sulfate362 ––sickleave 170 bone marrow 315 chromametry 392 – – topical therapy 463 – transplantation 350 chromatin 313 ––treatment 18,451 Bowenoid papulosis 122 chromosome – eyelid eczema 74 brain-derived neurotrophic factor –1q21247,297 –familyhistory 213 (BDNF) 359 –3q21247,261 –feet76 breast feeding 26, 47, 437, 449 –5q426 – hand eczema 88, 166, 167 Brocq’s theory 14 – 5q31.33 257 – manifestation 433 bronchial –5q34245 – march 108, 151, 433 –asthma5,317 – 11q13 245 –respiratorydisease – – eosinophilic inflammation 108 – 17q25 247 – – personal history 214 – hyperresponsiveness (BHR) 108, –20p248 – skin diathesis 168, 173 318 –region238 – winter feet 41, 76, 77, 88 ––riskfactors 109 – segment 5q31–32 239 atopiform dermatitis 203 Buckley’s syndrome 207 –Xp23259 atopy budesonide 111 chronic – definition 84 bufexamac 181, 231 – granulomatous disease (CGD) 207, – etiopathophysiology 3 bullous impetigo 116 209 –features61 burning sensation 573 – inflammatory skin disease 100 – patch test (APT) 97, 182, 275, 281, – obstructive pulmonary disease 392, 396, 428, 443, 444 C fiber 222, 305, 427 (COPD) 382 –stigmata70 Ctypelectinfamily 266 – vesicular dyshidrotic hand autoantigen 351 calcineurin 489 eczema 541 autogenic training 550 – inhibitor 282 chymase 307, 352 autoimmune disease 133 calcitonin gene-related peptide fibers chymotrypsin-like enzyme 159 autologous blood therapy 587 (CGRP) 219, 357 ciliary dyskinesia 382 autonomic nervous system 427 calcium chlorid 161 cilomilast 558 axon 357 calcium-binding protein 420 cipamfylline 558 – reflex experimental model 358 Candida albicans 117, 128, 300 Cladosporium 395 azole derivative 599 candidategene 237,238,244,256, Claudine family 184 260, 434 cleansing agent 526 Bcell 269,271,288,412 –study259 climate 511 B lymphocyte 269 candidiasis 101 –chamber382 bacterial carboxypeptidase 307 climatic adaptation 511 – antigen 351 carcinogenicity 600 climatotherapy 508, 513, 516 – infection 115, 436, 599 Caspase-I 185 clinical bacteriology 16 cataract 126 – assessment 21 Bacterium prodigiosum 471 cathepsin G 307 – manifestation 62 Bacteroides vulgatus 452 C-C chemokine 219, 240 cluster chemokine 341 bamboo hair 103 cedar pollen pollinosis 410 coeliac disease 127 barrier cefuroxime 494 cold cream 530 –disruption183 cephalosporin 484 cold-pressure test 547 – dysfunction 368 ceramides 363,366,376,414,458,530 common variable immunodeficiency – function 183 cetirizine 154, 504, 505 (CVID) 206 – homeostasis 332 cheilitis 37, 75, 89 complimentary alternative medicine basidiomycete 446 chemical peeling 161 (CAM) 582 basophils 279,352,392 chemokines 185, 187, 282, 318, 334, congenital ichthyosiform beclomethasone dipropionate 110, 111 340 erythroderma 103 Behcet’s disease 304 – superfamily 340 constitutional stigmata 70, 71 Besnier’s prurigo 13 childhood eczema 39 contact beta-adrenergic blockade 17 Children’s Dermatology Life Quality – allergy(CA) 58,178,429 beta-hemolytic streptococcus 118 Index (CDLQI) 33 – dermatitis 7, 101 betamethasone 572 Children’s Life Quality Index – hypersensitivity 335 Bifidobacterium 450 (CLQI) 33 –urticaria230 bioengineering 392 Chinese herbal medicine 586, 592, contamination 537 bioresonance 587 603 Coombs and Gell classification 6 Birbeck granule 288, 289, 394 chlorhexidine 492 Coprinus comatus 446 Subject Index 607 corneocyte 158, 182, 220, 524 dermatitis, see also atopic dermatitis, early colonization 453 corneodesmosome 220 atopic eczema 4 Early Treatment of the Atopic Child corneotherapy 528 – herpetiformis Duhring (DHD) 101 (ETAC) study 153 cornified cell envelope (CE) 247 – papulosa juvenilis (DPJ) 78 East-West-German differences 23 corticophobia 598 dermatofibrosarcoma 134 E-cadherin 185, 328, 333 corticosteroid 55, 272, 368, 477–479, dermatogenic enteropathy 127 eczema, see also atopic eczema, atopic 561, 571, 598 Dermatology Life Quality Index dermatitis 4 – unwanted effects 482 (DLQI) 33 – herpeticum 43, 53, 118, 119, 230, cortisol 477 dermatomyositis 102 497, 599 cortisone 18, 548 Dermatophagoides pteronyssinnus –infantum40 Corynebacterium acnes 472 278, 392, 395, 396, 507 – molluscatum 120, 121 cosmetics 531 dermatophytic infection 116 – nails 86 costimulatory molecule expression 291 dermatophytosis 101 – of the dorsum penis 76 costs 34 dermocorticophobia 18 – school academy 576 cow’s milk allergy 128, 154, 443 desensitization 17 – vaccinatum 120, 230 cradle cap 45, 228 desloratadine 504, 598 –verrucatum124 Crohn’s disease 127 desquamation 158 eczematous skin lesion 218 cross-contact 537 dexamethasone 308 educationprogramme 35,552,577 crusting 49 diabetes mellitus 144, 162 effector T cell 187 crystalline phase 220 diacylglycerol (DAG)-dependent egg allergy 154 cue-controlled relaxation 551 protein kinase C 336 elicitation phase 186 Cushing syndrome 483 diagnostic criteria 21, 48, 90 elimination diet 535, 537, 600 cutaneous – according to Hanifin and Rajka 91 elucidation 548 – barrier function 459 – according to Ring 91 EMG biofeedback 550 –biopsy51 – according to UK working party 90 emollients 525, 528 –catarrh45 diesel exhaust particulate (DEP) 386, emotional – lymphocyte-associated antigen 507 –expression568 (CLA) 323, 333, 343, 393 diet 535, 600 – problems 31 – lymphoma 129 dietary allergen 16 emulsion bath oil 528 –T-celllymphoma102 DiGeorgi anomaly 104 endometriosis 133 cyclic adenosine monophosphat digestive disturbance 46 endothelial-leukocyte adhesion (cAMP) 547 dimethylsulfoxide (DMSO) 184, 373 molecule-1 (ELAM-1) 307 cyclones 511, 512 dinitrochlorobenzene (DNCB) 178, endotoxin 27 cyclopentanoperhydrophenanthrene 203 –exposure435 484 direct costs 34 endurance training 517 cyclosporin 33, 34, 318, 368, 368, 540, dirty neck sign 77 Enterococcus faecalis 452 602 disease gene discovery 256 environmental cystic fibrosis (CF) 127 disseminated wart 123 –allergen420,433 cytokine 185, 187, 307, 315, 318, 350, domestic allergen exposure 435 – control 601 351, 377 Dorfman-Chanarin syndrome 289 – pollution 376 – gene cluster 257 double-blind placebo-controlled food – tobacco smoke (ETS) 385 –production336 challenge (DBPCFC) 400, 536 envoplakin 366 Down’s syndrome 132 enzyme Dactylis glomerata 445 doxepin 226 –chymotrypsin-like159 defensin 531 Drosophila 419, 452 –trypsin-like159 delayed-type hypersensitivity 186, drug sensitivity 130 eosinophil 112,299,300,305,313, 324, 350 dry skin, see also xerosis 63, 83, 89, 317, 351, 392, 428, 560 dendritic cell (DC) 185, 265, 267, 288, 157–163, 183, 219, 457, 524 –activation317 298, 335 – associated diseases 161 – cationic protein (ECP) 112, 210, – trafficking 344 –irritants160 313, 345, 382, 453, 539 Dennie-Morgan infraorbital fold – medication 163 – eosinophil-derived protein 340 (Morgan’s fold, Dennie’s fold) 65, 89 – seasonal changes 160 – peroxidase (EPO) 110, 112 depression 545, 548 – UV irradiation 160 –recruitment345 dermal Dubowitz syndrome 103, 132 eosinophilia 391 –fibroblast346 dust mite allergen, see also house dust eosinophilic –fibrosis352 mite 391, 435 –gastroenteritis127 derma-membrane structure (DMS) dyshidrosis 88 –inflammation110 formulation 530 dyshidrotic eczema 43 –proteinX(EPX)452 Dermatitis Family Impact eotaxin 316,325,334 Questionnaire (DFI) 33 earlobe rhagade 75 epicutaneous testing 417 608 Subject Index

epidermal fibronectin 316, 407 Gottron sign 102 – barrier 444 – fibronectin-binding protein 406 G-protein-coupled receptor 325, 341, ––dysfunction 191 fingerpad eczema 76 343 ––function 487,526,529 fingertip eczema 88 graft-versus-host disease (GvHD) 101 – – homeostasis 182 fish oil 586 grass pollen 74, 445 – dendritic cell phenotyping flare-up 56, 574 growth impairment 129 (EDCP) 290 flexural – differentiation complex (EDC) 247, – dermatitis/eczema 38, 48, 228 Haemophilus influenzae 205, 206 249 –lesion84 hairdresser 174 – growth factor receptor (EGFR) 334 fluconazole 497 hairy leukoplakia 203 ––activation 334 fluocortinbutyl 478 hand eczema 86, 88, 166–169, 456, 541 ––ligand 334 follicular eczema 229 hapten 184, 186, 187, 333, 415 – hyperplasia 218, 415 food Hartnup’s disease 128 –lipid362 – allergen 58, 296, 300, 396, 442 hay fever 4, 151, 152 epidermis 352, 362, 368 – allergy 153, 399, 400, 402, 441, 534 head, neck and shoulder dermatitis epoxy resin 180 ––testing 602 (HNS dermatitis) 117, 230 Eppendorf Itch Questionnaire 224, –challenge536 health service planning 31 225, 376 – food-specific IgE 401 hearing loss 131 Epstein-Barr virus (EBV) 203 foot eczema 541 heat shock protein (HSP) 377 –antibodies122 formaldehyde 381 Hebra’s prurigo 12, 13 erythema 41, 77 frictional contact dermatitis 78 heliotherapy 515, 516 erythromycin 493 fungal aeroallergen 497 Helsinki Early Intervention Childhood Escherichia coli 205, 206 fur hat-like hairline 69 Asthma (HEICA) 111 E-selectin 187, 282, 316, 323, 343 furry pet 26 hematopoietic stem cell 277 essential fatty acid 585 fusidic acid 494, 599 hematopoietin 317 esterification 477, 478 heparin 306 European Task Force on Atopic gamma linolenic acid 54 herbal treatment 586 Dermatitis (ETFAD) 444 gamma-globulin 119 Herpes simplex 43, 53, 101, 497, 573 evaporimeter 383 gastric hyposecretion 127 Herthoge’s sign 68, 69, 90 excoriation 40 gastrointestinal disorder 126, 127, 231 HESTIBAR test procedure 545 exfoliating cheilitis 75 GATA-3 190 high-affinity IgE receptor exfoliative erythroderma 43, 124 gene (FceRI) 188, 239, 258, 279, 290, 298, exocytosis 363 –disorder248 317, 570 expressed sequence tag (EST) 340 – manipulation technology 410 histamine 6,222,223,270,278,304, extracellular matrix (ECM) 327 – mapping 262 305, 352, 353, 384, 401, 417, 421, 519 extracorporal photopheresis 600 genetic histidine decarboxylase 353 extracutaneous viral disease 122 –atopyrisk24 histidinemia 129 extrinsic – etiology 235 histiocytosis X, see also Letterer-Siwe – allergic bronchial asthma 4 – heterogeneity 256 disease 102 –atopiceczema265 – predisposition 426 Hodgkin’s disease 129 eyelid eczema 65, 68, 74, 88 genital wart 123 Hom s 1 420 ezrin-radixin-moesin family 248 genome 238, 245, 260 homeopathy 587, 592 genomicimprinting 241,249,255 homiothermia 511 facial pallor 67, 90 Gentian violet 495 horny layer 457 F-actin polymerization 278 German Infant Nutrition and hostility 545 familial eosinophilia 248 Intervention Study (GINI) 26 house dust mite 26, 54, 296, 394, 428 family environment 549 gingivostomatitis herpetica 118 –allergen266 farnesol 493 glomerulonephritis 128 HPV type 16 122 Fas Glu420-Lys 240 human –expression333 glucocerebrosidase 161, 364 – biometeorological research 512 – ligand 327, 328 glucocorticoid 118, 126, 282, 318, 466, – immunodeficiency virus – receptor 56, 317 474, 477, 540, 589 (HIV) 101, 122, 210 fatty glucosaminoglycan (GAG) 306 ––xerosis 162 – acid 364, 366, 585 glucosyl-ceramide 364 – neutrophilic lipocalin (HNL) 112 – ointment 529, 530 glycerol 460, 466, 530, 597 Hurler’s syndrome 128 FceRI (high-affinity IgE receptor) glycocalix 453 hydrocortisone 368, 477, 484, 551 188, 258, 279, 290, 298, 570 GM-CSF (granulocyte-macrophage – butyrate 293,559,571 fexofenadine 504 colony stimulating factor) 332, 335, –actate571 fibrinogen 407 336, 351 hydrogel 465 fibroblast 334 –mRNA336 hydrophilic emulsion 465 Subject Index 609 hydrophobic cream 529 immunoglobulin-deficiency itraconazole 497 hydrotherapy 517 syndrome 203 hydroxyzine 57 immunological Janus kinase 3 (JAK3) 412 hygiene hypothesis 57, 189, 449, 452 –synapse267 Job’s syndrome 207 Hymenoptera venom allergy 131, 231 – tolerance 453 juvenile hypericum extract 587 immunophenotyping 290 – papular dermatosis 78 hyper-IgE syndrome 52, 95, 104, 207 immunoreceptor tyrosine activation – plantar dermatosis 77, 78, 88 hyper-IgM syndrome (HIGM) 132, motif (ITAM) 304 – – atopy-associated 78 208, 258 impetiginization 42, 49, 53, 230 – – nonatopic variant 78 hyperimmunoglobulinemia impetiginized eczema 42, 406 –E,see hyper-IgE syndrome imprints 64 Kaposi-Juliusberg syndrome 53 –M,see hyper-IgM syndrome incidence rate 22 Kaposi’s varicelliform eruption 117 hyperkeratosis 77, 78, 218, 411 indirect costs 34 keratinocyte 188, 189, 297, 332, 458, hyperlinearity infantile atopic eczema 39, 45, 85 472 – of the palms 63, 80 – diagnostic criteria 48 – apoptosis 328 – of the soles 63, 89 – differential diagnosis 50 keratoconjunctivitis 125 hyperpigmentation 42 infantile seborrhoeic dermatitis 18, keratoconus 125 hyperplasia 411 46 keratohyaline granules 63 hyperreflexia 133 Infant’s Dermatitis Quality of Life keratosis hypersensitivity 6 Index (IDQoL) 33 – follicularis 41, 90, 118, 219, 229 hypoallergenic diet 450 infection 230, 436 kerosene 383 hypocorticism 483 –oftheskin482 ketotifen 110 hypoproteinemia 134 inflammation 67 Kitamura-Takahashi-Sasagawa hyposensitization 152 inflammatory syndrome 80 hypothalamus-pituitary-adrenal – bowel disease 127 Klebsiella species 492 cortical axis 547 – dendritic epidermal cell hypothyroidism 69 (IDEC) 188,276,288,290,340,344, Lactobacillus 450 394, 570 – acidophilus 452 ichthyosis 162 infliximab 106 – GG 450 – linearis circumflexa Comel infraorbital fold 65, 89 – reuteri 452 (ILC) 103 inhalant 390, 396, 399 – rhamnosus 450, 452 – vulgaris 49, 63, 64, 363 insect venom allergy 131 lactose intolerance 534 ichthyotic palm 219 insulin promoter gene 144 Langerhans cell 185, 275, 277, 288, idiosyncrasy 14 insulin-dependent diabetes mellitus 298, 323, 334, 335, 340, 344, 351, 393, IFN (IDMD) 144, 231 394, 428, 559 –a 413 integrin 328 –histiocytosis50 – g 144, 187, 189, 190, 265, 272, 297, intellectualization 567 lanolin alcohol 181 298, 326, 329, 333, 342, 557 intercellular laser Doppler imaging technique 374, IgE 96, 265, 326, 570 – adhesion molecule (ICAM) 333 386 – antibodies 188,214,428 – lipids 157, 159, 472 Lassar’s paste 18 – autoreactivity 418, 419, 421 interferon, see IFN latex 169 – hyperresponsiveness 332 interferon-inducing factor (IGIF) 352 Leiner’s disease 103 – IgE-mediated allergy 38, 270, 296 interleukin, see IL LEKTI (lymphoepithelial Kazal-type –molecule17 International Study of Asthma and related inhibitor) 209, 248, 307 – regulation 6,265,269,271,413 Allergy in Childhood (ISAAC) 228 Letterer-Siwe disease 102 – sensitization 296, 326 interview 22 leukotriene 417 – testing 58 intrinsic atopic eczema 265 Levocetirizine 504 IgG autoantibody 421 involucrin 366 lichen chronicus (VIDAL) 16 IL 333, 350 irritable skin 373 lichenification 14, 48, 218 –1 377 irritancy testing 374 lich´enification g´eante 125 –– q 297 irritant 429, 458, 601 lichenoid 86, 353 – 4 187, 257, 265, 275 – contact dermatitis (ICD) 168, 472 lid eczema 74 – – receptor 240, 270, 297 –exposure172 light sensitivity 375 ––transgenicmice 415 isotype switching 270 linkage analysis 237 illness-specific mental stress 551 itch 37, 40, 222, 228, 358, 375, 414, linoleic acid 367 immunodeficiency 103 427, 550, 580 lipid 362 – syndromes 132 – diathesis 13 –body318 immunoglobulin 270 – itch-scratch cycle 225 – peroxidation 160, 531 –E,see IgE – mediators in inflamed skin 222 – solvents 375 –G,see IgG –rash23 lipocortin 479 610 Subject Index

lipophilic meteorological complex entity 512 neutral protease 306 –drug466 MHC 244, 272 NFkB 480 –emulsion463 microbial –activation188 lipopolysaccharide (LPS) 435 – colonization 191, 428 nickel 180, 181, 191 liposome 530 – infection 300, 428 – patch test 459 lipoteichoic acid (LTA) 407, 408 microemulsion 525 niosome 530 Lod score 237 milk protein hydrolysate 54 nipple eczema 76, 89 log of the odds 237 mineral 588 nitrogen dioxide 382 long-chain saturated fatty acid (LCFA) minor symptoms 37 nocturnal pruritus 53 158 mitochondria 358 nonatopic eczema 426 loratadine 505 MOAHL index 179 noninvolved skin of atopic dermatitis loricrin 366 MOAHL-FA index 179 (NIAD) 161 low hairline 69 moisture accumulation test nonionic alkylpolyglycoside 530 L-selectin 187, 316 (MAT) 457 NOx exposure 27 Luciferyellowuptake 291 moisturizer 459, 466, 528 nummular eczema 49, 86, 219 Lucky Luke diaper dermatitis 54 molecular genetics 426 lung function 108 molluscum contagiosum 120–122, 498 occupational lupus erythematosus 345 mometasone furoate (MMF) 478, 505 – contact dermatitis (OCD) 168 lymphangiectasia of the small monocyte 189, 278, 300 –exposure171 intestine 127 – chemotactic protein 316 – guidelines 175 lymphocytes 41 – monocyte-derived dendritic – skin disease 168, 172 –Tregulatory 188 cell 278, 291 – – attributable risks 173 lymphohistiocytic infiltrate 288 montelukast 113 octanol/water partition lymphotactin 341 mouse coefficient 181 – asthma model 336 octenidine 493 macrophage 277, 288, 560 – chromosome 262 ocular disease 124, 231 – macrophage-derived chemokine – model 325, 344 Oid-Oid disease 289 (MDC) 325 mucosal atopy 169, 459 oil emulsion 463 macropinocytosis 266 mupirocin 485 oil-in-water emulsion 464, 525 macular amyloidosis 133 muscle relaxation 550 ointment magnesium 161 music therapy 565 – solution-type 484 major basic protein (MBP) 314, 345 –active566 – suspension-type 484 major histocompatibility complex –receptive566 oleic acid vehicle 466 (MHC) 265 musical improvisation 566 oligoantigenic diet 535 Malassezia 496 m-xylene 384, 385 omalizumab 281 – furfur 42, 399 mycosis 117 omega-hydroxy ceramides 158, 159, – sympodialis 81 – fungoides 102, 129, 323 161 manganese superoxide dismutase 418 mycotic infection 116 oozing 11, 40, 41, 49 maritime climate 514 myeloid 278 open air rest treatment 508, 516 massage therapy 587 myeloperoxidase 112 oral mast cell 187, 238, 262, 279, 303, 308, myositis-specific autoantibodies 102 – allergy syndrome (OAS) 536 352, 381 –antihistamines57 –activation304 natural moisturizing factor – provocation test 442, 536 – chymase 238, 257 (NMF) 530 orbital darkening 68, 90 – mediator 305 NC/Nga mice 411 OSSAD 32 –protease306 necrosis 421 osteomyelitis 116, 230 –tryptase245 neomycin 181, 485, 494 ovalbumin 346,381,387,384 mastocytosis 303, 304 nephropathy 592 oxidative stress 377 maternal atopic dermatitis 216 nephrosis 123 ozone 387, 507, 587 McGill Pain Questionnaire 224 nerve growth factor (NGF) 359, 414 measles infection 25, 123 Netherton’s syndrome 52, 102, 103, palmar hyperlinearity 64 Melaleuca alternifolia 493 132, 209, 248, 260, 289 palmo-plantar keratoderma 131 melanocytic nervus 147 –gene239 papule 39, 84 melanoma 147 neurasthenia 13 papulovesicular lesion 86 memory T cell recruitment 342 “Neurodermitis trainer” 578 PAR-2 222 Mendelian disorder 259 neurokinin A 357 paraffin gel 485 Mendel’s laws 256 neuropeptide (NP) 357 parakeratosis 218, 229, 411 menthol 226 – substance P 219, 357 parasitic disorders 123 metabolic disorder 128 –Y(NPY)357 parent-of-origin effect 255, 260 metachromasia 303 neurotrophin 359 Parent’s Index of Quality of Life in Subject Index 611

Atopic Dermatitis (PIQoL-AD) 33 –allergen402 pruritic skin rash 391 passive smoking 601 –allergy536 pruritus 10, 50, 56, 89, 222, 225, 255, patch testing 58, 97, 178 –grains266,384 399, 573 patchy pityriasiform lichenoid – pollen-sensitive atopic eczema 24 P-selectin 187, 316 eczema 79, 80 pollinosis 74, 79 – glycoprotein ligand 323 paternal pollutant 429 PsoralenandultravioletA(PUVA) – atopic dermatitis 216, 241 polyethylen glycol 529 therapy 126, 496, 599 –imprinting241 –gel465 – therapy 541, 600 pathogenetic factors 426 polyhexadine 492 psoriasin 247 patient management program 549 polyunsaturated fatty acid psoriasis 10, 95, 130, 145, 162, 231, peak exspiratory flow 108 (PUFA) 585 239, 246, 297, 333–335, 345, 358 pedagogic module 578 pompholyx 43, 88 –susceptibility238 Pediatric Symptom Checklist 33 popliteal eczema 38 psychoimmunology 546 pemphigus foliaceus 101 porrigo 11 psychological penicillin 494 positional cloning 235 – disturbance 231 3-pentadecylcatechol (PDC) 178 positive predictive value (PPV) 401 – training program 553 peptidoglycan (PGN) 407 positron emission tomography psychometric test 547 perennial rhinitis 68, 152 (PET) 223 psychosomatic perioral eczema 75 poxvirus 121, 499 – factors 25 periorbital darkening 90 (see allergic – officinalis vaccination 120 –illness545 shiners) PPAR- * 185 –influence427 peripheral p-phenylenediamine 180 psychotherapeutic treatment 549, – blood 300, 315, 351 precursor 10 568, 602 – nerve 357 prednisolone 477 pulpite periplakin 366 prednisone 43 –digitalekeratosiquer´ecidivante 76 perl`eche 75, 89 pre-employment screening 175 –s`eche 76, 167 peroxisome proliferator-activated pregnancy 437 pulpitis sicca 88 (see pulpite s`eche) receptor-a ligand 367 prevalence 22 pustule 39 petrolatum 368 prevention 54, 436 pustulosis vacciniformis acuta 117 phenol 226 –primary 437 pyridoxine 588 phenylalanine hydroxylase (PAH) 104 – secondary 438 phenylketonuria 104, 128 Preventive Allergy Treatment (PAT) quality of life (QOL) 32, 544 phorbol ester 334, 335 study 110 questionnaire 22, 23 phosphodiesterase (PDE) prick testing 58, 81, 96 – on Experience with Skin Complaints – 4 inhibitors 557 primary immunodeficiency (PID) (QES) 32 – – antiinflammatory activity 559 syndrome 202, 204, 210 –enzymes557 primrose oil 585 radiation 587 phospholipase A 324 probiotics 26, 54, 450, 451, 602 radioallergosorbent test (RAST) 96, phospholipid 157 profibrotic cytokine 394 395, 418, 535 phosphorylation 412 prognostic factors 27 –reaction241 photoprovocation testing 540 prohapten 184 RANTES 240, 245, 259, 316, 325, 336 photosensitivity 130 proinflammatory cytokine 381 rash 358 phototherapy 496, 539 Propionibacterium 472, 473 rebound phenomenon 486 phytotherapy 528, 586 propylene glycol 466 reflex erythema 90 picryl chloride 415 prosaposin 365 respiratory pili torti 103 prostaglandin E2 6, 267, 342, 386 –allergy417 pimecrolimus 55, 57, 282, 292, 489, protein –syncytialvirus449 496, 571, 572 –A 407 retroauricular intertrigo 75 pityriasis – nitrogen unit (PNU) 446 rhagades 77 –alba89 – oxidation 160 rheumatoid arthritis 146, 231 – rosea 134 –synthesis366 rhinitis 4, 391 Pityrosporum 203 (see Malassezia) proteoglycan 306 Rhus toxicodendron 178 – orbiculare 117, 446 Proteus species 492 roxithromycin 493 – ovale 42,204,300 provocation test 400, 441 – species 291 prurigo 11, 87, 518 salt plantar hyperlinearity 64 – Besnier’s 13 –bath588 plasmocytoid dendritic cell 276–278 –diath´esique 5 –water517 polar emulsion 463 –ferox12 Sarcoptes scabiei 101 polidocanol 181 –Hebra’s12,13 scabies 10, 50, 95, 101 pollen 387 – nodularis 359 Schwann cell 358 612 Subject Index

SCORAD 32, 55, 91, 225, 229, 407, –lesion84 – steroid-responsive nephrotic 442, 451, 504, 576 –lipid458 syndrome (SRNS) 128 – classification –milk529 stigmata of atopic eczema 4, 62, 375, ––ofedema/papulation 93 – permeability barrier function 368 377 ––oferythema 93 – pricktest 96,215,244,296,442, stigmatization 32, 567 – – of excoriation 94 445, 534 stratum corneum 157, 161, 182, 362, – – of lichenification 95 – protocol 580 364, 524 ––ofoozing/crusting 94 – skin-selective homing ligand 324 –hydration158 –evaluationform 92 – surface conductance (SSC) 413 –lipids367 –tool224 – pH 471, 473, 526 –proteins159 scratching 414, 427, 551 –tumor203 streptococcal impetigo 116 sebaceous gland lipid 159 sleep disturbance 130 Streptomyces tsukubaensis 570 seborrhoeic dermatitis 46, 49, 95, smallpox 53, 120 streptozotocin (STZ) 181 100, 101, 204, 358 – vaccination 498 stress 544, 546, 580 sebostasis 63 soap 468, 471, 526 – coping technique 551 sedation 503 social environment 565 strophulus 11 selective IgA deficiency 95, 206, socioeconomic status (SES) 25 subacute eczematous lesion 85 208 sodium sudden infant death syndrome Self-Administered Eczema Area and – dodecyl sulfate (SDS) 373, 473 (SIDS) 132 Severity Index (SA-EASI) 32 – lauryl sulfate (SLS) 160, 373, 473, sulfur dioxide 383 self-esteem 579 527 superinfection 53 self-respect 579 sorption-desorption test 457 supplementation diet 600 semisolid emulsion 464 soybean oil 585 surface lipid 367, 376 senile xerosis 163 specific surfactant 426, 469, 527 sensitization 184 –IgE sweating 375 – experiment 178 – – antibodies 96 switch recombinase system 270 sensory ––level 401 syndet 469, 471, 474, 536, 597 –fiber357 – immunotherapy (SIT) 272 synthetic detergent/surfactant 469 – nerve system 223 –serumIgE442 systemic immunity 353 serine protease 239, 257 sphingomyelin 362, 364 Serratia marcescens 471 –deacylase161 Tcell 298,428,570 serum sphingomyelinase 366 –activation267,271 –cortisol518 sphingosine 498 – allergen-specific clones 275 –IgElevel96,104 SPINK5 248, 249, 260, 307 – chemotaxis 325 – immunoglobulin 410 spondylosis 133 – lymphoma 102, 129 severe combined immunodeficiency spongiosis 80, 229, 328, 559 – polarization 268 (SCID) 104 – of the follicular epithelium 79, 81 – receptor (TCR) 267 S´ezarysyndrome 102,124,129,323 spreading bath oil 528 –response342 SF-36 34 stage-adapted treatment 597 – skin-selective homing 323 shaking lotion 465 staphylococcal –subset186 Shwachman syndrome 209 – colonization 571 – suppression 202 Sickness Impact Profile (SIP) 34 – enterotoxin B (SEB) 324 T helper cell 265, 278, 342 silent atopy 71 –infection116 – polarization 268 single nucleotide polymorphism – peptidoglycan 408 T lymphocytes 333, 393 (SNP) 239, 297 – scalded skin syndrome (SSSS) 116 T regulatory (Tr) lymphocytes 188 skin Staphylococcus T regulatory cell (Treg) 190 –aging163 – albus 472 T2-mediated delayed-type – barrier function 220, 275, 413, 427, – aureus 40, 53, 101, 118, 190, 203, hypersensitivity reaction 281 456 230, 249, 300, 353, 399, 406, 471, 472, tachyphylaxis 487 –care597 485, 492, 560, 571 tacrolimus 33, 34, 55, 57, 282, 292, – cleansing 468, 526 – – coagulase-positive 115 293, 318, 368, 489, 496, 570–572, 602 – colonization 406 – – infection 207 tar preparation 18, 486 –disease START (Steroid Treatment As Regular tea tree oil (TTO) 493 (see Melalenca) – – chronic inflammatory 100 Therapy in early asthma) terbutaline 111 ––impact 31 study 111 terfenadine 497 – eosinophilia 346 stasis dermatitis 181 tetra-chloroethylene 385 – hydration 457, 466 STAT6 190 textiles 375 – hyperirritability 378 status eczematicus 378 TGF- q 1240 – infection 203 stem cell factor 303 Th1 –inflammation558 steroid 110,111,495 – dichotomy 25 Subject Index 613

– Th1-mediated disease 144, 147 transmission disequilibrium testing venom allergy 131 (see Hymen- Th2 (TDT) 238, 256 optera) –dichotomy25 trichophytin 117 vernal keratoconjunctivitis 125 – phenotype 144 Trichophyton rubrum 117 vesicles 41, 84 – Th2-mediated disease 144 trichorrhexis –onerythematousskin84 thalassotherapy 511, 514, 516 – invaginata 103, 260 vesicular virus infection 498 theory of Brocq 14 – nodosa 103 viral therapeutic triclosan 492 – infection 118, 202, 276 – discussion 566 trisomy 21 132 –skinaffection497 –project55 truncal –wart123 thermoregulation 520 – dermatitis 38 visual analog scale (VAS) 224 thick liquid emulsion 464 –lesion85 vitamine 588 thymic trypsin-like enzyme 159 –B2588 –hypoplasia104 tubular dressing 56 – E 530, 588 – stromal lymphopoietin tumornecrosisfactora,see TNF- [ vitiligo 89, 131 (TSLP) 189, 275, 335 twin study 255 Vohwinkel’s syndrome 247 thymidine incorporation assay 291 Tzanck smear test 119, 497 volatile organic compounds thymus and activation-regulated (VOC) 376, 384 chemokine 325 UK Working Party’s Diagnostic for von Recklingshausen’s disease 241 tinea corporis 89 Atopy Dermatitis Criteria 90 (see tissue diagnostic criteria) Waardenburg-Klein syndrome 131 – damage 421 ulcerative colitis 127 wart 123 – eosinophilia 313, 315 ultraviolet radiation 516 (see UV) water-free emulsion 463 – microenvironment 345 unconventional therapy option water-in-oil emulsion 464 tixocortol pivalate 484 (UTO) 603 weather reaction 511 TNF- [ 185, 297, 307, 315, 333, 344, urea 460, 466, 474, 530, 597 wheat allergy 402 350, 377 uremia 162 white dermatographism 66, 70, 90 tobacco smoke 27, 385 urticaria 12, 41, 58, 308 Wiskott-Aldrich tolerance 453 – pigmentosa 304 – protein (WASP) 205 toll-like receptor (TLR) 277, 352, 408, utility question 34 – syndrome (WAS) 95, 103, 202, 204, 452 UV 240, 259 toluene 385 – A/B phototherapy 588 – – eczema 205 topical – A1 phototherapy 539 work-related exogenous factor 166 –antibiotics56 –Bradiation541 World Allergy Organization (WAO) 7 – corticosteroids 8, 56, 226, 282, 482, – irradiation 130, 573, 599 wrist eczema 85 486, 487 –light368 – immunomodulator 292, 496 xenobiotics 181, 182, 184 – inhibitors of calcineurin 489 (see vaccination 25, 498 xerosis, see also dry skin 39, 41, 49, tacrolimus, pimecrolimus) vaccinia virus 498 63, 89, 160, 350, 524, 526, 528 –preparation181 vacular endothelium 344 X-linked –treatment55 varicella zoster virus infection 122 – agammaglobulinemia (Bruton) 207 –vehicles463 vasoactive – hypohidrotic ectodermal total serum IgE level 244 – intestinal peptide (VIP) 357 dysplasia 51 training program 576 –mediator427 – ichthyosis (RXI) 162 transepidermal water loss vasoconstriction (TEWL) 158, 183, 219, 374, 382, – of small blood vessels 67 Yamamoto’s sign 38, 41 384, 456, 520, 524 –test478 transforming growth factor beta vasocortin 479 Zemaphyte 586 (TGF- q )453 vasomotor rhinitis 4