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2015 Annual Report “ It’s cancer.” 2015 ANNUAL REPORT ANNUAL 2015 MEMORIAL SLOAN KETTERING CANCER CENTER IMPROVING PATIENT OUTCOMES GENERAL INFORMATION PHYSICIAN REFERRAL SERVICE 212.639.2000 800.525.2225 1275 YORK AVENUE VISIT US ONLINE FACEBOOK.COM/SLOANKETTERING NEW YORK, NY 10065 WWW.MSKCC.ORG TWITTER.COM/SLOAN_KETTERING YOUTUBE.COM/MSKCC INSTAGRAM.COM/SLOANKETTERING 2015 ANNUAL REPORT WWW.MSKCC.ORG/ANNUALREPORT 2015 AR 1 IN 2015, MORE THAN 1.6 MILLION PEOPLE IN THE UNITED STATES FACED A CANCER DIAGNOSIS. AT MSK, WE’RE LEADING THE WAY IN SETTING STANDARDS FOR THE DELIVERY AND QUALITY OF CANCER CARE NATIONWIDE. Melanoma cells (orange) and their nuclei (blue) alongside normal skin cells (green) Memorial Sloan Kettering Cancer Center Improving Patient Outcomes 2 CONTENTS Message from the Chairman and the President 04 OUTSMARTING CANCER 08 THE RIGHT TREATMENT AT THE RIGHT TIME 20 PATIENT COMFORT AND SATISFACTION 32 INCREASING AND IMPROVING ACCESS TO CARE 44 JOSIE ROBERTSON SURGERY CENTER 58 Statistical Profile The Campaign for Memorial Sloan Kettering 64 71 Financial Summary Donors to the Campaign for 66 Memorial Sloan Kettering Boards of Overseers and Managers 72 68 The Society of Memorial Sloan Kettering Leadership Cancer Center 69 87 Medical oncologist and breast cancer expert Tiffany Traina with her patient Tracy Friedman 2015 AR 3 Memorial Sloan Kettering Cancer Center Improving Patient Outcomes 4 Message from the Chairman and the President CRAIG THOMPSON DOUGLAS WARNER III PRESIDENT AND CHAIR, BOARDS OF OVERSEERS CHIEF EXECUTIVE OFFICER AND MANAGERS To enhance care delivery and extend our expertise to more patients, in 2015 Memorial Sloan Kettering embarked on a bold expansion of our facilities and implemented powerful new technologies that more efficiently and precisely attack cancer. 2015 AR 5 MSK is the nation’s first cancer hospital. a founding member of the Sean Parker That legacy continues to drive our focus Institute for Cancer Immunotherapy, which on generating meaningful discoveries will accelerate the pace at which these new that change our understanding of cancer applications are developed. as a disease and applying those insights to improve the effectiveness of cancer MSK-IMPACT® — a test created by our treatment. MSK’s 2015 Annual Report genome scientists, bioinformaticians, and takes improving outcomes as a broad theme molecular pathologists — detects gene because it touches every aspect of our work, mutations and other aberrations in both rare from the bedside to the laboratory. and common cancers. Since 2014, the test has sequenced more than 10,000 patients’ While the oncology community continues to tumors. Data generated by this effort are make gains in cancer research and treatment, enabling MSK scientists to better understand there are noteworthy gaps in achieving how specific mutations affect both cancer exceptional care for patients. The quality treatment and disease progression, thus and cost of cancer treatment are inconsistent changing how cancer is treated. A landmark across the nation and survival rates vary study published in 2015 in the New England widely. Indeed, an important recent study by Journal of Medicine by MSK authors David researchers in Memorial Sloan Kettering’s Hyman and José Baselga illustrated how Center for Health Policy and Outcomes and MSK-IMPACT data could be used to group other MSK colleagues showed that Medicare patients whose tumors shared the same patients treated at freestanding cancer mutation — regardless of where their cancer centers have significantly better outcomes originated. It represented the first “basket than those treated at community-based trial,” in which treatment was based on the hospitals. The need to develop more effective mutation in a patient’s tumor rather than on strategies to prevent, detect, and treat cancer the site where that tumor developed. (To learn remains urgent. But these findings remind us more, read “Outsmarting Cancer” beginning that we have an equally pressing imperative: on page 8.) to bring together patients, clinicians, insurers, and policy experts to develop new Researchers are also combining this wealth of approaches to providing cancer treatment. MSK-IMPACT genomic data with information We have an opportunity to dig more deeply about family history and inherited genetic into differences in care and to identify how mutations as part of the Robert and Kate to improve outcomes for people in the United Niehaus Center for Inherited Cancer States and around the world. To that end, Genomics. The goal of the Niehaus Center, MSK has joined with other dedicated cancer led by Kenneth Offit, Chief of the Clinical centers to lead a national conversation about Genetics Service, is to identify opportunities quality care and outcomes. to diagnose hereditary cancers at their earliest, most curable stages — the equivalent MSK remains at the leading edge of immuno- of a cancer genomics prevention program. oncology. From pioneering research into immune regulation, our physicians and In late 2015, we began seeing patients at our scientists introduced the concept of immune magnificent new Josie Robertson Surgery checkpoint blockade therapy. Today, Center, which has been specially designed to drugs that target immune checkpoints are allow patients to return home either the day unleashing the power of the immune system of or the day after a surgical procedure. You to detect and eradicate cancer. These same can read more about the facility, as well as the concepts have also led to the reengineering contributions our cadre of nurses made to its of patient T cells to specifically recognize development, beginning on page 58. tumors. And early in 2016, MSK became Memorial Sloan Kettering Cancer Center Improving Patient Outcomes 6 The MSK Cancer Alliance, formed in 2013 Chemical biology is bringing new analytic to forge partnerships between MSK and techniques, molecular probes, and potential community oncology providers, is creating a therapeutic leads to biomedical research and new model for the delivery of — and patient to cancer research in particular. To take full access to — the highest-quality care. It’s not advantage of this, we created the Chemical even been three years and the Alliance now Biology Program within SKI under the KATHRYN MARTIN outstanding leadership of chemist Derek Tan Chief Operating Officer includes Hartford HealthCare, a multihospital system in Connecticut, and the Lehigh Valley in 2015. Health Network in Pennsylvania. The Miami Cancer Institute, part of South Florida’s To further the development of models for Baptist Health System, is on track to become precision cancer treatment, Scott Lowe, the third member. Chair of the Cancer Biology and Genetics Program, and David Solit, Director of the On other fronts, MSK researchers have Marie-Josée and Henry R. Kravis Center for been hard at work learning more about how Molecular Oncology, were awarded a five- JOSÉ BASELGA cancer develops and grows and revealing its year, $10 million grant to support the use of Physician-in-Chief and Chief Medical Officer, Memorial Hospital vulnerabilities. genomic, computational, and animal modeling to more closely investigate specific cancers. CRISPR/Cas9, a gene-editing technique that can target and modify DNA with extraordinary These are just a few examples that prove accuracy, was hailed by Science magazine as the adage that an organization is made the most important breakthrough of 2015. stronger and more vibrant by the collective Several MSK scientists are using this tool to contributions of a diverse and talented staff. understand cancer biology. Andrea Ventura of MSK itself received a significant honor the Cancer Biology and Genetics Program at reflecting the exceptional capabilities of our JOAN MASSAGUÉ Director, Sloan Kettering Institute the Sloan Kettering Institute (SKI) published nurses. In early 2016, following a multiday a paper in Nature in early 2015 in which he site visit in December, the American Nurses used CRISPR to engineer chromosomal Credentialing Center granted us Magnet rearrangements to create a specific lung recognition®, a distinction given to hospitals cancer model that can be used preclinically to that demonstrate nursing excellence. evaluate chemotherapeutics. This achievement confirms the superb performance of the entire nursing staff, led by Cryo-electron microscopy — which uses Chief Nursing Officer Elizabeth McCormick, electron beams to study molecules in atomic and marks the culmination of a years-long JAMES D. ROBINSON III Honorary Chair, Boards of Overseers detail at cryogenic temperatures — is sending effort that involved MSK nurses at all levels. and Managers tremors through the world of structural biology. Nikola Pavletich, Christopher Lima, MSK’s staff of more than 14,000 men and and Stephen Long of SKI’s Structural Biology women gives selflessly of themselves to ensure Program applied the revolutionary technology our success. Each year we welcome new to provide new insights into molecules as members to our family; 2015 was no exception. diverse as the mTORC1 complex and cell membrane–spanning calcium channels. MSK Renowned clinician and genitourinary cancer will soon be installing a Titan Krios cryo- researcher Philip Kantoff was one of our electron microscope that will advance research most noteworthy recruits. Dr. Kantoff joined into the essential operating machinery of the MSK as Chair of the Department of Medicine cell and how molecules implicated in disease after holding several leadership positions at might be targeted
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