Harvard Medical School Curriculum Vitae

Date Prepared: April 14, 2019

Name: A. Heather Eliassen

Office Address: 181 Longwood Avenue Boston, MA 02115

Home Address: 22 Grayson Road Winchester, MA 01890

Work Phone: (617) 525-2104

Work E-Mail: [email protected]

Work Fax: (617) 525-2008

Place of Birth: Cambridge, MA

Education 1995 A.B. History Dartmouth College, Hanover NH 2001 S.M. Epidemiology Harvard T.H. Chan School of Public Health (Harvard Chan School), Boston MA 2004 Sc.D. Epidemiology HSPH (Susan E. Hankinson, ScD)

Postdoctoral Training 09/2001- Research Fellow Epidemiology Brigham and Women’s Hospital 03/2006 (began before (BWH), Boston MA doctoral degree completed) 11/2004- Research Fellow Epidemiology Harvard Medical School (HMS), 01/2006 (Susan E. Hankinson, ScD) Boston MA 11/2004- Research Fellow Epidemiology Harvard Chan School 10/2007 (Susan E. Hankinson, ScD)

Faculty Academic Appointments 03/2006- Instructor Department of Medicine HMS 02/2009 03/2009- Assistant Professor Department of Medicine HMS 03/2015 05/2011- Assistant Professor Department of Epidemiology Harvard Chan School 04/2015 04/2015- Associate Professor Department of Medicine HMS 05/2015- Associate Professor Department of Epidemiology Harvard Chan School 1

Appointments at Hospitals/Affiliated Institutions 04/2006- Associate Department of Medicine BWH Epidemiologist Channing Division of Network Medicine

Other Professional Positions 1996-1999 Clinical Research Coordinator ASTHMA, Inc., Seattle, WA 2000 Research Assistant Fred Hutchinson Cancer Research Center, Seattle, WA

Major Administrative Leadership Positions Local 2007-2014 Director of Data Management BWH BWH/Harvard Cohorts Biorepository 2009-2017 Associate Director Harvard Chan School Nurses’ Health Study II (NHSII) 2011-2015 Associate Director BWH BWH/Harvard Cohorts Biorepository 2012- Co-Leader/Co-Founder BWH Breast Cancer Working Group 2014-2017 Co-Leader BWH Channing Division of Network Medicine Strategic Planning: Disease Subtyping 2014-2017 2017- Co-Principal Investigator Harvard Chan School & BWH Nurses’ Health Study II (NHSII) 2017- Director, BWH/Harvard Cohorts Biorepository Harvard Chan School & BWH 2018- Co-Lead, Dana Farber/Harvard Cancer Center Dana Farber Cancer Institute and Cancer Epidemiology Harvard University

International 2007-2012 Chair/Founder International Collaborative Group Plasma Carotenoids and Breast Cancer Collaborative Group

Committee Service Local 2008-2012 Dissertation Committee: Sara Hendrickson Harvard Chan School 2008-2012 Member 2008-2014 Channing Division of Network Medicine Peer BWH Mentoring Committee 2008-2014 Peer Mentor 2011-2014 Co-Leader 2008- BWH/Harvard Cohorts Biorepository Advisory BWH Board 2008- Member 2011 Oral Exam Committee: Seungyoun Jung HSPH 2 2011 Member 2011-2012 Dissertation Committee: Seungyoun Jung Harvard Chan School 2011-2012 Member 2012- Admissions Review Committee: Cancer Harvard Chan School Epidemiology 2012- Committee Member 2013- Invitational Grants Internal Review Committee BWH 2013- Committee Member 2013-2014 Channing Division of Network Medicine Strategic BWH Planning Initiative 2013-2014 Member 2013-2015 Dissertation Committee: Akweley Ablorth Harvard Chan School 2013-2015 Member 2014 Oral Exam Committee: Leslie Farland Harvard Chan School 2014 Member 2014 Oral Exam Committee: Tianyi Huang Harvard Chan School 2014 Chair 2014-2015 Dissertation Committee: Tianyi Huang Harvard Chan School 2014-2015 Member 2014-2016 Dissertation Committee: Leslie Farland Harvard Chan School 2014-2016 Member 2015 Oral Exam Committee: Kevin Kensler Harvard Chan School 2015 Chair 2016 Oral Exam Committee: Mollie Barnard Harvard Chan School 2016 Chair 2015-2018 Dissertation Committee: Kevin Kensler Harvard Chan School 2015-2018 Member 2016-2018 Dissertation Committee: Mollie Barnard Harvard Chan School 2016-2018 Member 2018 Oral Exam Committee: Aviva Musicus Harvard Chan School 2018 Chair 2018- Executive Committee: Dana Farber/Harvard Dana Farber Cancer Institute and Cancer Center (DF/HCC) Population Sciences Harvard University 2018- Executive Committee Member

National 2011- Vitamin D Pooling Project of Breast and NCI Cohort Consortium Colorectal Cancers 2011- Member 2015 Your Disease Risk Scientific Advisory Panel Washington University 2015 Member 2017- Consortium of Metabolomics Studies (COMETS) NIH Consortium 2017- Member 2017- Steering Committee Member 2018- NCI Cohort Consortium Steering Committee NCI Cohort Consortium 2018- Member 2019- NCI Cohort Consortium Steering Committee NCI Cohort Consortium Working Group Subcommittee 3 2019- Chair

International 2009- Endogenous Hormones and Breast Cancer Oxford University Collaborative Group 2009- Member 2011- International Collaborations on Epidemiologic Oxford University Studies of Breast, Ovarian, and Endometrial Cancers 2011- Member 2013- Premenopausal Breast Cancer Collaborative NCI Cohort Consortium Group Member 2013- 2019- International 100K Cohort Consortium, Founded NIH/Wellcome Trust, Global by Heads of International Research Organizations Genomic Medicine Collaborative 2019- Member

Professional Societies 2003- Society for Epidemiologic Research 2003- Member 2014 Member, Abstract Review Committee, 47th Annual Meeting 2015 Member, Poster Judging Committee, 48th Annual Meeting 2017 Session Chair, 50th Annual Meeting 2017- Member, Membership and Nominations Committee 2018 Member, Abstract Review Committee, 51st Annual Meeting 2003- American Association for Cancer Research (AACR) 2003-2008 Associate Member 2008- Active Member 2011 Endocrine Society 2011 Member 2016- American Society of Nutrition 2016- Member 2018- Metabolomics Society 2018- Member

Grant Review Activities National 2005-2006 Massachusetts Chapter Grants Study Section Susan G. Komen Breast Cancer Foundation 2005-2006 Member 2013-2016 Breast Cancer Research Program Study Section Department of Defense 2013-2016 Member 4 2017- Breast Cancer Research Program Study Section Department of Defense 2017- Chair 2018 Pilot Award Program Arkansas Breast Cancer Research Program 2018 Member International 2010, International Grant Programme Peer Review World Cancer Research Fund 2013, 2015 Panel 2010 Ad hoc member 2013 Ad hoc member 2015 Ad hoc member 2018 Ad hoc member

2011- Department of Public Health and Innovation Call Italian Ministry of Health for Grants Study Section 2011- Member 2012 Prevention Translation Supplement Awards Panel Canadian Cancer Society Research Institute 2012 Member 2013 Population Research Committee Study Section Cancer Research UK 2013 Ad hoc member 2014 Prevention Research Grants Panel Canadian Cancer Society Research Institute 2014 Member 2014, 2015 Peer Review Panel Deutsche Forschungsgemeinschaft (German Research Foundation) 2014, 2015 Ad hoc member 2016 External Peer Reviewer Alberta Innovates Health Solutions 2016 Ad hoc member 2016 International Peer Reviewer Health Research Board, Ireland 2016 Ad hoc member 2017- International Peer Reviewer Italian Association for Cancer Research 2017- Ad hoc member 2018 Population Research Committee Study Section Cancer Research UK 2018 Ad hoc member 2018 Medical Research Council Peer Review UK Research and Innovation Medical Research Council 2018 Ad hoc member

Editorial Activities Ad hoc Reviewer Annals of Nutrition and Metabolism Annals of Oncology American Journal of Clinical Nutrition 5 American Journal of Epidemiology British Journal of Cancer British Journal of Nutrition Breast Cancer Research Breast Cancer Research & Treatment Cancer Epidemiology Cancer Epidemiology, Biomarkers & Prevention Cancer Prevention Research Cancer Research Clinical Nutrition Clinical Translational Medicine Endocrine & Metabolism Environmental Research European Journal of Clinical Nutrition Expert Review of Endocrinology & Metabolism Genome Medicine International Journal of Cancer Journal of Adolescent Health Journal of the American Medical Association JAMA Internal Medicine (formerly Archives of Internal Medicine) Journal of Clinical Endocrinology & Metabolism Journal of the National Cancer Institute Journal of Translational Medicine Metabolomics New England Journal of Medicine Nutrition & Metabolism Nutrition Research PLOS ONE Public Health Nutrition

Other Editorial Roles 2014- Associate Editor Cancer Causes & Control 2017- Editorial Board Member Journal of the National Cancer Institute and Journal of the National Cancer Institute Cancer Spectrum 2019 Chapter Review: Metabolic Change and IARC World Cancer Report Metabolomics

Honors and Prizes 1992-1995 College Honor List Dartmouth College Academics 1994-1995 Distinctive Scholastic Dartmouth College Academics Accomplishment 2003 Selected Participant, AACR Academics “Pathobiology of Cancer” Workshop, Keystone, CO 2004 Teaching Fellowship Award Harvard Chan School Academics

6 Department of Epidemiology 2005 Highly Rated Abstract , 4th AACR Research Annual AACR Conference on Frontiers in Cancer Prevention Research 2006 Molecular Epidemiology AACR Research Working Group (MEG)/AACR Scholar in Training Award, 97th Annual Meeting 2010 Outstanding Poster Award BWH Biomedical Research Research Institute Cancer Research Center Poster Session 2011 Highly Rated Poster AACR Research Presentation (top 2%), 102nd Annual Meeting 2014 High Overall Rating for Harvard Chan School Committee Teaching course EPI246 on Educational Policy 2015 Top fifty highest-cited Journal of the National Cancer Research article published in 2012 Institute 2016-17 BWH Faculty Mentoring BWH Mentoring Leadership Program – Cohort VII 2017 Mid-Career Women Faculty American Academy of Medical Academics Leadership Development Colleges Seminar

Report of Funded Projects Past 2001- Training Grant in Epidemiology and Prevention of Breast Cancer (PI: Colditz) 2004 Department of Defense Training grant DAMD17-00-1-0165 Predoctoral Fellow This grant provided predoctoral training in cancer epidemiology with a primary focus on breast cancer for my dissertation. 2004- Nutritional Epidemiology of Cancer (PI: Stampfer) 2007 NCI Training Grant R25 CA098566 Postdoctoral Fellow This grant provided postdoctoral training with a focus on the role of diet and nutrition in the etiology of breast cancer. With this funding, I published several papers and was subsequently funded to pursue the role of plasma carotenoids in breast cancer risk. 2007- Predictors of Plasma Carotenoids Levels 2008 NCI Career Development Award Breast Cancer Specialized Programs of Research Excellence (SPORE) P01 CA089393 Principal Investigator ($24,429) The aim of this grant was to develop a statistical model to predict plasma carotenoid levels using dietary and lifestyle information and validate the model in an independent data set. 7 2007- Plasma Carotenoids and Breast Cancer Risk – Pooled Analysis of Prospective Studies 2009 NCI R03 CA128073 Principal Investigator ($100,000) In this study, I utilized existing data from six prospective case-control studies of plasma carotenoids and the risk of breast cancer. The following studies are included in this proposal: Columbia, Missouri; Umeå, Sweden; New York University Women’s Health Study; Washington County, Maryland; Nurses’ Health Study (NHS); and Women’s Health Study. These studies represented >80% of the world’s published literature on plasma carotenoids and breast cancer risk; the combined analysis included 3,055 cases and 3,956 controls. 2007- Premenopausal Hormone Levels and Risk of Breast Cancer (PI: Hankinson) 2014 NCI R01 CA67262 Co-Investigator Served as Project Director of this grant and as such, led analyses related to the specific aims (e.g., premenopausal sex steroid hormones, urinary estrogen metabolites, plasma vitamin D, plasma insulin and c-peptide) and mentored doctoral students and post- doctoral fellows working on the grant. 2008- Urinary Estrogen Metabolites and Breast Cancer Etiology in Premenopausal Women 2009 Brigham and Women’s Hospital Fellowship, Eleanor and Miles Shore Fellowship for Scholars in Medicine Principal Investigator ($30,000) The goal of this project was to further our understanding of the role of estrogen metabolites in breast cancer etiology in premenopausal women. My aims included assessing the reproducibility of 15 estrogens and estrogen metabolites over time, examining the association between these metabolites and breast cancer risk, and investigating the correlations between the metabolites and breast cancer risk factors. 2009- Plasma marker of oxidative stress and risk of breast cancer: a prospective study 2013 Susan G. Komen Foundation KG0906845 Principal Investigator ($470,332) Utilizing a novel biomarker for global oxidative stress, we will investigate the role oxidative stress plays in the etiology of breast cancer among premenopausal women in the NHS and the NHSII. 2009- Oxidative Stress, Antioxidants and Risk of Breast Cancer: A Prospective Analysis 2014 NCI R01 CA131218 Principal Investigator ($1,338,113) The goal of this grant is to further our understanding of the role of oxidative stress in the etiology of breast cancer. Specifically, we will assess a novel plasma marker of oxidative stress, plasma carotenoid levels, and genetic variation in antioxidant-related genes with respect to breast cancer risk in the NHS. 2009- Risk Factors for Breast Cancer in Younger Nurses (PI: Willett) 2014 NCI R01 CA050385 Site Principal Investigator ($2,953,310) The goal of this grant is to continue following the 116,430 women enrolled in 1989 in the NHSII. We will assess risk of breast cancer in premenopausal and postmenopausal women through an evaluation of dietary and lifestyle factors during adolescence and early adult life, biomarkers that reflect dietary factors, mammographic density, and a new genetic risk score. As Project Director, I oversee the cohort infrastructure and the

8 scientific aims, as well as mentor doctoral students and post-doctoral fellows working on the grant. 2004- Biochemical Markers in the Nurses' Health Study (PI: Hankinson) 2014 NCI R01 CA49449 Co-investigator This project seeks to identify and validate biomarkers – particularly hormonal markers – that predict risk of invasive breast cancer in postmenopausal women. Using a prospective nested case-control design, we plan to analyze blood samples collected from the 32,826 participants in the NHS who provided a blood sample in 1989-90 and, for 18,743 of these women, a second sample in 1999-2000. As a co-investigator, I have led analyses related to specific aims including plasma sex steroid hormones, plasma vitamin D, and plasma estrogen metabolites. 2013- Breast Cancer Risk Factors Among Women Aged 75 and Older (PI: Schonberg) 2016 National Institute of Aging (NIA) R01 AG041869 Site Principal Investigator ($171,591) In this application we will identify risk factors for late-life breast cancer and use these factors to develop and validate a clinical prediction tool for women aged 75 and older to be used by older women and their doctors to make more informed decisions about breast cancer screening, thereby improving both their quality of care and quality of life. 2013- Biomarkers and Breast Cancer Risk Prediction in Younger Women (PI: Zeleniuch- 2016 Jacquotte) NCI R01 CA178949 Site Principal Investigator ($223,635) The goal of this proposal is to improve the performance of the Gail breast cancer risk prediction model 2 for women 35-49 years of age, by the addition of biomarkers (testosterone or free testosterone, and/or Müllerian Inhibiting Substance (MIS)). 2012- Circulating Fatty Acids and Breast Cancer Risk: A Prospective Study 2016 NCI R01 CA160246 Principal Investigator ($952,456) The goal of this grant is to further our understanding of the role of specific fatty acids, from both diet and endogenous production, in breast cancer. Specifically, we will measure 45 individual fatty acids in archived red blood cell samples in a nested case- control study within the NHSII. 2013- Life Course Cancer Epidemiology Cohort in Women (PI: Willett) 2018 NCI UM1 CA176726 Site Principal Investigator ($4,323,783) The goal is to continue the follow-up of the NHSII, a cohort of 116,430 women with repeated, cycle timed biomarkers and measures of diet, physical activity, and other exposures over several decades. Cohort follow-up is reaching the most informative phase and is a unique resource for scientific aims that integrate diet, other lifestyle variables, biomarkers, genetic predisposition and mediating variables in relation to cancer. As co-PI of the cohort, I oversee the infrastructure and the scientific aims, as well as mentor doctoral students and postdoctoral fellows working on the grant.

Current 2015- Risk Factors for Breast Cancer in Younger Nurses (MPI: Willett, Eliassen) 2020 NCI R01 CA050385 Multiple Principal Investigator ($2,872,511) 9 The goal of this grant is to examine plasma metabolites in relation to breast cancer risk, assess the interrelation of diet and metabolomics in breast cancer etiology, and explore the role of potentially modifiable risk factors in activation of the PI3K pathway. The aims will be conducted within the Nurses’ Health Study cohort of 116,430 women followed since 1989. 2015- Dietary and Hormonal Determinants of Cancer in Women (Stampfer, Tamimi) 2020 NCI P01CA87969 Co-Investigator Our long-term objective is to identify novel hormonal, dietary and genetic determinants of breast, colorectal, and ovarian cancer risk in women, focusing on prevention and survival. We will leverage questionnaire data, blood and urine samples, and tumor tissue, coupled with long-term (up to 36 years) follow-up. 2015- Adverse health effects of shift work (Schernhammer) 2019 NIOSH R01 OH009803 Co-Investigator Our study seeks to further our understanding of how exposure in utero to shift work may increase risk for chronic diseases later in life. We will utilize our unique data to study the effects of shift work, particularly during pregnancy, on the health of women’s children. 2016- Cancer Center Support Grant (Glimcher) 2021 NCI P30CA006516 Co-Investigator The primary goal of the Center is to promote collaborative interactions that will lead to new approaches to cancer prevention, diagnosis and treatment. 2017- Endogenous hormones and postmenopausal breast cancer: Etiologic insights and 2022 improving risk prediction (PI: Hankinson) NCI R01 CA207369 Site Principal Investigator ($998,519) We propose to continue our research group’s work to identify and validate hormonal markers that predict risk of invasive breast cancer in postmenopausal women. Specifically, we will (1) evaluate several new hormonal markers relevant to the estrogen and insulin pathways, (2) incorporate tumor heterogeneity into these analyses, (3) extend and validate the addition of these biomarkers to current breast cancer risk prediction models. 2018- Life Course Cancer Epidemiology Cohort in Women (MPI: Willett/Eliassen) 2023 NCI U01 CA176726 MPI ($6,731,569) The goal is to continue the follow-up of the NHSII, a cohort of 116,430 women with repeated, cycle timed biomarkers and measures of diet, physical activity, and other exposures over several decades. Cohort follow-up is reaching the most informative phase and is a unique resource for scientific aims that integrate diet, other lifestyle variables, biomarkers, genetic predisposition and mediating variables in relation to cancer. As co-PI of the cohort, I oversee the infrastructure and the scientific aims, as well as mentor doctoral students and postdoctoral fellows working on the grant.

Report of Local Teaching and Training 10 Teaching of Students in Courses Harvard Chan School 2000 Epidemiology of Infectious Diseases of Public Health Importance in Developing Countries Graduate Students Teaching Assistant: Three 2-hr classes per week for ten weeks 2002 Introduction to Epidemiology Graduate students Teaching Assistant: Three 2-hr classes per week for ten weeks 2002-2004 Elements of Epidemiologic Research Graduate students Teaching Assistant: Three 2-hr classes per week for nine weeks 2005 Analysis of Case-Control and Cohort Studies Graduate students Teaching Assistant: Two 2-hr classes, one 1-hr lab per week for eight weeks 2005-2006 Introduction to Epidemiology Undergraduate students One 2-hr seminar 2011, ID510: Nutritional Epidemiology of Cancer 2013, Graduate students One 2-hr lecture with discussion 2015, 2017 2011, EPI246: Applied Biomarkers in Cancer 2013, Epidemiology 2015, 2017 Graduate students Two 2-hr classes per week for eight weeks 2014-2016 EPI205: Practice of Epidemiology One 2-hr class per week for ten Graduate students weeks 2019 EPI240: Biomarkers in Epidemiology Research One 2-hr class per week for eight Graduate students weeks

Harvard Chan School and Karolinska Institute 2006 Summer School in Biostatistics and Epidemiology, Treviso, Italy: Cancer Epidemiology and Biomarkers Clinicians and postdoctoral fellows 7 hrs per day for one week

HMS 2008 RM511.0: Role of Discovery in Medicine First-year medical students Three 2-hr seminars per week for two weeks 2009 SIM501.0: Scholarship in Medicine First-year medical students Three 2-hr seminars per week for four weeks

Laboratory and Other Research Supervisory and Training Responsibilities 2008- Supervision of Harvard Chan School Weekly to monthly mentorship epidemiology doctoral students

11 2008- Guidance of seven doctoral students via Monthly to quarterly mentorship membership on orals and dissertation committees 2010- Supervision of Harvard Chan School and HMS Weekly mentorship of 1-2 fellows postdoctoral fellows

Formally Supervised Trainees Graduate Students 2011-2015 Julia Sisti, ScD / City Research Scientist, Research and Evaluation Unit, Bureau of Chronic Disease Prevention and Tobacco Control, New York City Department of Health and Mental Hygiene Published three first-author papers; three co-author manuscripts, one additional manuscript in progress 2012-2015 Hannah Oh, ScD, MPH / Assistant Professor, Department of Health Policy and Management, Korea University Published four first-author manuscripts, two co-author manuscripts 2015-2017 Sarah Irvin, MS, ScM / Doctoral Student, Department of Epidemiology and Biostatistics, University of Maryland School of Public Health 2017-2018 Yumeng Ren, MBBS, ScM / Doctoral Student, Department of Epidemiology, University of North Carolina 2017- Kristen Brantley, MPH / Doctoral Student, Department of Epidemiology, Harvard T.H. Chan School of Public Health 2018- Emma McGee, BA / Masters Student, Department of Epidemiology, Harvard T.H. Chan School of Public Health Postdoctoral Fellows 2010-2013 Renee Fortner, PhD / Scientist, German Cancer Research Center, Heidelberg Published five first-author papers, six co-author manuscripts 2013-2015 Kelly Hirko, PhD / Assistant Professor, Michigan State University Published six first-author manuscripts, one co-author manuscript 2016-2018 Claire Kim, PhD / Team member, Epidemiology/Biostatistics Division, Rare Disease Registries, Sanofi Genzyme Published one first-author paper, one additional manuscript in progress 2017- Oana Zeleznik, PhD / Postdoctoral Fellow, Department of Epidemiology, Harvard T.H. Chan School of Public Health Analyses and manuscripts ongoing 2017- Claire Cadeau / Postdoctoral Fellow, Department of Epidemiology, Harvard T.H. Chan School of Public Health Analyses and manuscripts ongoing

Local Invited Presentations No presentations below were sponsored by outside entities. 2003 Use of Lipid-Lowering Drugs in Relation to Breast Cancer Risk / Monthly Seminar Cancer Epidemiology Training Grant Presentation, Harvard Chan School 2003 Tubal Ligation in Relation to Risk of Breast Cancer / Monthly Seminar Cancer Epidemiology Training Grant Presentation, Harvard Chan School 2005 Predicted Risk, Endogenous Hormones, and Risk of Breast Cancer / Monthly Seminar Cancer Epidemiology Training Grant Presentation, Harvard Chan School 2005 Circulating Insulin, C-peptide and Breast Cancer Risk / Monthly Seminar Cancer Epidemiology Training Grant Presentation, Harvard Chan School 12 2005 Endogenous Steroid Hormones and Risk of Breast Cancer Among Premenopausal Women / Weekly Seminar Channing Laboratory, BWH 2006 Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal Women / Presentation to the External Advisory Board Nurses’ Health Studies, Channing Laboratory, BWH 2006 Associations of Reproductive Factors and Family History of Breast Cancer with Prolactin Levels / Monthly Seminar Cancer Epidemiology Training Grant Presentation, Harvard Chan School 2006 Use of Aspirin and Other NSAIDs and Risk of Breast Cancer in Premenopausal Women / Monthly Seminar Cancer Epidemiology Training Grant Presentation, Harvard Chan School 2006 Oxidative Stress, Antioxidants and Risk of Breast Cancer: Proposal / Monthly Seminar Nutritional Epidemiology of Cancer Training Grant Presentation, Harvard Chan School 2009 Urinary Estrogen Metabolites and Risk of Cancer Among Premenopausal Women / Presentation to the External Advisory Board Nurses’ Health Studies, Channing Laboratory, BWH 2010 Carotenoids and Breast Cancer: Evidence to Date and Pooled Analysis of Plasma Markers / Lunchtime Seminar Series Department of Epidemiology, Harvard Chan School 2011 Circulating Vitamin D and Breast Cancer Risk: Repeated Exposure Assessment and 18 Years of Follow-up in the Nurses' Health Study / Molecular Pathology Working Group Channing Laboratory, BWH 2013 Breast Cancer in the Nurses’ Health Studies / Annual Retreat Channing Division of Network Medicine, BWH 2013 Breast Cancer: Intricacies of Exposures and Outcomes / Brief Update Monthly Series Dana Farber/Harvard Cancer Center 2013 Obesity Across the Lifecourse and Risk of Breast Cancer / Monthly Seminar Dana Farber/Harvard Cancer Center Breast Cancer Program 2016 Demystifying Promotions / Seminar Series Center for Faculty Development and Diversity, BWH and Office for Faculty Affairs, HMS 2016 10+ Years of My Work in Breast Cancer Epidemiology (in 5 Minutes) / Faculty Meeting Department of Epidemiology, Harvard Chan School 2016 Carotenoids and Risk of Breast Cancer / Faculty Meeting Channing Division of Network Medicine, BWH

Report of Regional, National and International Invited Teaching and Presentations Regional No presentations below were sponsored by outside entities. 2006 Adult Weight Change and Postmenopausal Breast Cancer Risk / Grand Rounds Cancer Prevention and Control Center, Boston University, Boston MA 2018 BWH/Harvard Cohorts Biorepository / Invited Lecture AACR Molecular Epidemiology Workshop, Boston MA

National No presentations below were sponsored by outside entities. 13 2012 Effects of Pregnancy and Lactation on Hormones Associated with Subsequent Breast Cancer Risk / Invited Lecture Workshop on Postpartum Breast Remodeling, Lactation and Breast Cancer Risk: Towards Improved Risk Assessment and Prevention, National Cancer Institute, Rockville, MD 2012 Carotenoids and Breast Cancer: Pooled Analysis of Plasma Markers / Invited Lecture Breast Cancer Research Program Seminar Series, Alvin J. Siteman Cancer Center, Washington University Medical Center, St. Louis, MO 2013 Eat Your Colors: Carotenoids and Breast Cancer / Invited Lecture Research Seminar Series, New York University Cancer Institute, New York, NY 2014 Eat Your Colors: Carotenoids, Oxidative Stress and Risk of Breast Cancer / Invited Lecture Division of Cancer Epidemiology and Genetics Seminar Series, NCI, Rockville, MD 2014 Antioxidants, Oxidative Stress and Risk of Breast Cancer / Invited Lecture Cancer Center Seminar Series, University of Colorado School of Medicine, Denver, CO 2017 New Epidemiological Evidence on the Relationship Between Carotenoids and Breast Cancer Risk / Invited Lecture James A. Olson Memorial Lecture, CARIG Symposium, Chicago, IL 2017 Moving Towards Prevention: Modifiable Risk Factors for Breast Cancer / Invited Lecture National Breast Cancer Coalition, Advocate Leadership Summit, Washington DC 2017 Carotenoids and Breast Cancer: Evidence from Epidemiologic Studies / Invited Lecture American College of Nutrition, 58th Annual Conference, Alexandria, VA

International No presentations below were sponsored by outside entities. 2018 Breast Cancer in the Nurses’ Health Studies and Beyond: Lessons Learned and Future Directions / Invited Lecture Institute of Cancer Research, London UK 2018 Life Course Approach to Breast Cancer Epidemiology / Grand Rounds Women’s College Hospital, Toronto, Ontario Canada 2018 Using Biomarkers to Understand Breast Cancer Etiology, Prevention, and Risk Prediction / Invited Lecture German Cancer Research Center (DKFZ), Heidelberg Germany

National Abstract Oral Presentations No presentations below were sponsored by outside entities. 2005 Adult Weight Change and Risk of Postmenopausal Breast Cancer / Invited Lecture 4th AACR Frontiers in Cancer Prevention Research Conference, Baltimore, MD 2006 Endogenous Steroid Hormones and Risk of Breast Cancer Among Premenopausal Women / Invited Lecture 97th Annual Meeting of the AACR, Washington, DC 2014 Plasma Carotenoids and Risk of Breast Cancer Over 20 Years of Follow-up in the Nurses’ Health Study / Invited Lecture 105th Annual Meeting of the AACR, San Diego, CA

Report of Patient Education and Service to the Community 14 Activities No activities below were sponsored by outside entities. 2005 Young Epidemiology Scholars Competition / Judge Evaluated projects proposed by high school students 2006 Museum of Science, Boston, MA / Featured Lecturer The importance of weight change on the risk of breast cancer 2011 The Conquest of Cancer and the Next Generation of Cancer Researchers, 10th Annual AACR International Conference on Frontiers in Cancer Prevention Research / Mentor to high school students 2016 Muraco Elementary School, Winchester, MA / Featured Lecturer Introduction to Epidemiology

Report of Scholarship Peer reviewed publications Research investigations 1. Shapiro GG, Wighton TG, Chinn T, Zuckerman J, Eliassen AH, Picciano JF, Platts-Mills TA. House dust mite avoidance for children with asthma in homes of low-income families. J Allergy Clin Immunol. 1999;103(6):1069-1074. 2. Missmer SA, Eliassen AH, Barbieri RL, Hankinson SE. Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women. J Natl Cancer Inst. 2004;96(24):1856-1865. 3. Tworoger SS, Eliassen AH, Rosner B, Sluss P, Hankinson SE. Plasma prolactin concentrations and risk of postmenopausal breast cancer. Cancer Res. 2004;64(18):6814-6819. 4. Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE. Serum lipids, lipid-lowering drugs, and the risk of breast cancer. Arch Intern Med. 2005;165(19):2264-2271. 5. Eliassen AH, Colditz GA, Peterson KE, Furtado JD, Fay ME, Sorensen G, Emmons KM. Biomarker validation of dietary intervention in two multiethnic populations. Prev Chronic Dis. 2006;3(2):A44. PMC1563951 6. Eliassen AH, Colditz GA, Rosner B, Hankinson SE. Tubal sterilization in relation to breast cancer risk. Int J Cancer. 2006;118(8):2026-2030. 7. Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE. Adult weight change and risk of postmenopausal breast cancer. JAMA. 2006;296(2):193-201. 8. Eliassen AH, Missmer SA, Tworoger SS, Hankinson SE. Endogenous steroid hormone concentrations and risk of breast cancer: does the association vary by a woman's predicted breast cancer risk? J Clin Oncol. 2006;24(12):1823-1830. 9. Eliassen AH, Missmer SA, Tworoger SS, Spiegelman D, Barbieri RL, Dowsett M, Hankinson SE. Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst. 2006;98(19):1406-1415. 10. Tworoger SS, Eliassen AH, Missmer SA, Baer H, Rich-Edwards J, Michels KB, Barbieri RL, Dowsett M, Hankinson SE. Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2494-2501. 11. Tworoger SS, Missmer SA, Eliassen AH, Spiegelman D, Folkerd E, Dowsett M, Barbieri RL, Hankinson SE. The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women. Cancer Epidemiol Biomarkers Prev. 2006;15(5):967-971. 12. Eliassen AH, Tworoger SS, Hankinson SE. Reproductive factors and family history of breast cancer in relation to plasma prolactin levels in premenopausal and postmenopausal women. Int J Cancer. 2007;120(7):1536-1541. 15 13. Eliassen AH, Tworoger SS, Mantzoros CS, Pollak MN, Hankinson SE. Circulating insulin and c- peptide levels and risk of breast cancer among predominately premenopausal women. Cancer Epidemiol Biomarkers Prev. 2007;16(1):161-164. 14. Schernhammer ES, Tworoger SS, Eliassen AH, Missmer SA, Holly JM, Pollak MN, Hankinson SE. Body shape throughout life and correlations with IGFs and GH. Endocr Relat Cancer. 2007;14(3):721-732. 15. Tworoger SS, Eliassen AH, Kelesidis T, Colditz GA, Willett WC, Mantzoros CS, Hankinson SE. Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab. 2007;92(4):1510-1516. 16. Tworoger SS, Eliassen AH, Sluss P, Hankinson SE. A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer. J Clin Oncol. 2007;25(12):1482-1488. 17. Tworoger SS, Missmer SA, Eliassen AH, Barbieri RL, Dowsett M, Hankinson SE. Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Cancer Causes Control. 2007;18(7):743-752. 18. Eliassen AH, Missmer SA, Tworoger SS, Hankinson SE. Circulating 2-hydroxy- and 16alpha- hydroxy estrone levels and risk of breast cancer among postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2008;17(8):2029-2035. PMC2562592 19. Eliassen AH, Chen WY, Spiegelman D, Willett WC, Hunter DJ, Hankinson SE. Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and risk of breast cancer among premenopausal women in the Nurses' Health Study II. Arch Intern Med. 2009;169(2):115-121. PMC2632770 20. Kotsopoulos J, Eliassen AH, Missmer SA, Hankinson SE, Tworoger SS. Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women. Cancer. 2009;115(12):2765-74. PMC2764240 21. Su X, Hankinson SE, Clevenger CV, Eliassen AH, Tworoger SS. Energy balance, early life body size, and plasma prolactin levels in postmenopausal women. Cancer Causes Control. 2009;20(2):253-262. PMC2681294 22. Eliassen AH, Ziegler RG, Rosner B, Veenstra TD, Roman JM, Xu X, Hankinson SE. Reproducibility of fifteen urinary estrogens and estrogen metabolites over a 2- to 3- year period in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2009;18(11):2860-8. PMC2783292 23. Danforth KN, Eliassen AH, Tworoger SS, Missmer SA, Barbieri RL, Rosner BA, Colditz GA, Hankinson SE. The association of plasma androgen levels with breast, ovarian, and endometrial cancer risk factors among postmenopausal women. Int J Cancer; 2010;126(1):199-207. PMC2875384 24. Gates MA, Tworoger SS, Eliassen AH, Missmer SA, Hankinson SE. Analgesic use and sex steroid hormone concentrations in postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2010;19(4):1033-41. PMC2852496 25. Kotsopolous J, Tworoger SS, Campos H, Chung FL, Clevenger CV, Franke AA, Mantzoros C, Ricchiuti V, Willett WC, Hankinson SE, Eliassen AH. Reproducibility of plasma, urine and red blood cell biomarkers among premenopausal and postmenopausal women from the Nurses’ Health Studies. Cancer Epidemiol Biomarkers Prev. 2010;19(4):938-46. PMC2852492 26. Eliassen AH, Hankinson SE, Rosner B, Holmes MD, Willett WC. Physical activity and risk of breast cancer among postmenopausal women. Arch Intern Med. 2010;170(19):1758-64 PMC3142573

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Plasma carotenoid- and retinol- weighted gene scores and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2013;22(5):927-36. PMC3650115 43. Fortner RT, Eliassen AH, Spiegelman D, Willett WC, Barbieri RL, Hankinson SE. Premenopausal endogenous steroid hormones and breast cancer risk: results from the Nurses' Health Study II. Breast Cancer Res. 2013;15(2):R19. PMC3672790 44. Bauer SR*, Fortner RT*, Gates MA, Eliassen AH, Hankinson SE, Tworoger SS. Analgesic use in relation to sex hormone and prolactin concentrations in premenopausal women. Cancer Causes Control. 2013;24(6):1087-97. PMC3646978 (*These authors contributed equally) 45. Xie J, Tworoger SS, Franke AA, Terry KL, Rice MS, Rosner BA, Willett WC, Hankinson SE, Eliassen AH. Plasma enterolactone and breast cancer risk in the Nurses' Health Study II. Breast Cancer Res Treat. 2013;139(3):801-9. PMC3736336 46. 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Hirko KA, Chai B, Spiegelman D, Campos H, Farvid MS, Hankinson SE, Willett WC, Eliassen AH. Erythrocyte membrane fatty acids and breast cancer risk: a prospective analysis in the Nurses' Health Study II. Int J Cancer 2018;142(6):1116-1129. PMC5773390 148. Bertrand KA, Eliassen AH, Hankinson SE, Rosner BA, Tamimi RM. Circulating Hormones and Mammographic Density in Premenopausal Women. Horm Cancer. 2018;9(2):117–127. PMC5864534 149. Ge W, Clendenen TV, Afanasyeva Y, Koenig KL, Agnoli C, Brinton LA, Dorgan JF, Eliassen AH, Falk RT, Hallmans G, Hankinson SE, Hoffman-Bolton J, Key TJ, Krogh V, Nichols HB, Sandler DP, Schoemaker MJ, Sluss PM, Sund M, Swerdlow AJ, Visvanathan K, Liu M, Zeleniuch-Jacquotte A. Circulating anti-Mullerian hormone and breast cancer risk: A study in ten prospective cohorts. Int J Cancer. 2018;142(11):2215–2226. PMC5922424 150. Houghton LC, Sisti JS, Hankinson SE, Xie J, Xu X, Hoover RN, *Eliassen AH, *Ziegler RG. Estrogen metabolism in premenopausal women is related to early life body fatness. Cancer Epidemiol Biomarkers Prev. 2018;27(5):585–593. PMC5932230 (*These authors contributed equally) 151. Farvid MS, Eliassen AH, Cho E, Chen WY, Willett WC. Dairy Consumption in Adolescence and Early Adulthood and Risk of Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2018;27(5):575–584. PMC5943046 152. Kim CH, Tworoger SS, Stampfer MJ, Dillon ST, Gu X, Sawyer SJ, Chan AT, *Libermann TA, *Eliassen AH. Stability and reproducibility of proteomic profiles measured with an aptamer- based platform. Sci Rep. 2018;8(1):8382. PMC5976624 (*These authors contributed equally) 28 153. Bertone-Johnson ER, Manson JE, Purdue-Smithe AC, Steiner AZ, Eliassen AH, Hankinson SE, Rosner BA, Whitcomb BW. Anti-Müllerian hormone levels and incidence of early natural menopause in a prospective study. Hum Reprod. 2018;33(6):1175–1182. PMC6366539 154. McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, Cook NR, Eliassen AH, Zeleniuch-Jacquotte A, Agnoli C, Albanes D, Barnett MJ, Buring JE, Campbell PT, Clendenen TV, Freedman ND, Gapstur SM, Giovannucci EL, Goodman GG, Haiman CA, Ho GYF, Horst RL, Hou T, Huang W-Y, Jenab M, Jones ME, Joshu CE, Krogh V, Lee I-M, Lee JE, Männistö S, Le Marchand L, Mondul AM, Neuhouser ML, Platz EA, Purdue MP, Riboli E, Robsahm TE, Rohan TE, Sasazuki S, Schoemaker MJ, Sieri S, Stampfer MJ, Swerdlow AJ, Thomson CA, Tretli S, Tsugane S, Ursin G, Visvanathan K, White KK, Wu K, Yaun S-S, Zhang X, Willett WC, Gail MH, Ziegler RG, Smith-Warner SA. Circulating vitamin D and colorectal cancer risk: an international pooling project of 17 cohorts. J Natl Cancer Inst. 2019;111(2):158-169. PMC6376911 155. Wu L, Shi W, Long J, Guo X, Michailidou K, Beesley J, Bolla MK, Shu X-O, Lu Y, Cai Q, Al- Ejeh F, Rozali E, Wang Q, Dennis J, Li B, Zeng C, Feng H, Gusev A, Barfield RT, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Barrdahl M, Baynes C, Beckmann MW, Benítez J, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Brinton L, Broberg P, Brucker SY, Burwinkel B, Caldes T, Canzian F, Carter BD, Castelao JE, Chang-Claude J, Chen X, Cheng T-YD, Christiansen H, Clarke CL, NBCS Collaborators, Collée M, Cornelissen S, Couch FJ, Cox D, Cox A, Cross SS, Cunningham JM, Czene K, Daly MB, Devilee P, Doheny KF, Dork T, Santos Silva Dos I, Dumont M, Dwek M, Eccles DM, Eilber U, Eliassen AH, Engel C, Eriksson M, Fachal L, Fasching PA, Figueroa J, Flesch-Janys D, Fletcher O, Flyger H, Fritschi L, Gabrielson M, Gago-Dominguez M, Gapstur SM, García- Closas M, Gaudet MM, Ghoussaini M, Giles GG, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Guénel P, Hahnen E, Haiman CA, Hakansson N, Hall P, Hallberg E, Hamann U, Harrington P, Hein A, Hicks B, Hillemanns P, Hollestelle A, Hoover RN, Hopper JL, Huang G, Humphreys K, Hunter DJ, Jakubowska A, Janni W, John EM, Johnson N, Jones K, Jones ME, Jung A, Kaaks R, Kerin MJ, Khusnutdinova E, Kosma VM, Kristensen VN, Lambrechts D, Le Marchand L, Li J, Lindström S, Lissowska J, Lo WY, Loibl S, Lubinski J, Luccarini C, Lux MP, MacInnis RJ, Maishman T, Kostovska IM, Mannermaa A, Manson JE, Margolin S, Mavroudis D, Meijers-Heijboer H, Meindl A, Menon U, Meyer J, Mulligan AM, Neuhausen SL, Nevanlinna H, Neven P, Nielsen SF, Nordestgaard BG, Olopade OI, Olson JE, Olsson H, Peterlongo P, Peto J, Plaseska-Karanfilska D, Prentice R, Presneau N, Pylkas K, Rack B, Radice P, Rahman N, Rennert G, Rennert HS, Rhenius V, Romero A, Romm J, Rudolph A, Saloustros E, Sandler DP, Sawyer EJ, Schmidt MK, Schmutzler RK, Schneeweiss A, Scott RJ, Scott CG, Seal S, Shah M, Shrubsole MJ, Smeets A, Southey MC, Spinelli JJ, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper W, Taylor JA, Terry MB, Tessier DC, Thomas A, Thöne K, Tollenaar RAEM, Torres D, Truong T, Untch M, Vachon C, Van Den Berg D, Vincent D, Waisfisz Q, Weinberg CR, Wendt C, Whittemore AS, Wildiers H, Willett WC, Winqvist R, Wolk A, Xia L, Yang XR, Ziogas A, Ziv E, kConFab/AOCS Investigators, Dunning AM, Pharoah PDP, Simard J, Milne RL, Edwards SL, Kraft P, Easton DF, Chenevix-Trench G, and Zheng W. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. Nat Genet. 2018;50(7):968-978. PMC6314198 156. The Premenopausal Breast Cancer Collaborative Group, Schoemaker MJ, Nichols HB, Wright LB, Brook MN, Jones ME, O’Brien KM, Adami H-O, Baglietto L, Bernstein L, Bertrand KA, Boutron-Ruault M-C, Braaten T, Chen Y, Connor AE, Dorronsoro M, Dossus L, Eliassen AH, Giles GG, Hankinson SE, Kaaks R, Key TJ, Kirsh VA, Kitahara CM, Koh W-P, Larsson SC, Linet MS, Ma H, Masala G, Merritt MA, Milne RL, Overvad K, Ozasa K, Palmer JR, Peeters 29 PH, Riboli E, Rohan TE, Sadakane A, Sund M, Tamimi RM, Trichopoulou A, Ursin G, Vatten L, Visvanathan K, Weiderpass E, Willett WC, Wolk A, Yuan J-M, Zeleniuch-Jacquotte A, Sandler DP, Swerdlow AJ. Association of body mass index and age with subsequent breast cancer risk in premenopausal women. JAMA Oncol. 2018;4(11):e181771. PMC6248078 157. Farvid MS, Chen WY, Rosner BA, Tamimi RM, Willett WC, Eliassen AH. Fruit and vegetable consumption and breast cancer incidence: Repeated measures over 30 years of follow-up. Int J Cancer. 2019;144(7):1496-1510. PMC6440478 158. Yaghjyan L, Colditz G, Eliassen H, Rosner B, Gasparova A, Tamimi RM. Interactions of alcohol and postmenopausal hormone use in regards to mammographic breast density. Cancer Causes Control. 2018;29(8):751-758. PMC in progress 159. Samraj AN, Bertrand KA, Luben R, Khedri Z, Yu H, Nguyen D, Gregg CJ, Diaz SL, Sawyer S, Chen X, Eliassen AH, Padler-Karavani V, Wu K, Khaw K-T, Willett W, Varki A. Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N- glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk. PLoS ONE. 2018;13(6):e0197464. doi:10.1371/journal.pone.0197464. PMC6005533 160. Zhang X, Rice M, Tworoger SS, Rosner BA, Eliassen AH, Tamimi RM, Joshi AD, Lindström S, Qian J, Colditz GA, Willett WC, Kraft P, Hankinson SE. Addition of a polygenic risk score, mammographic density, and endogenous hormones to existing breast cancer risk prediction models: A nested case-control study. PLoS Med. 2018;15(9):e1002644. PMC6122802 161. Kensler KH, Beca F, Baker GM, Heng YJ, Beck AH, Schnitt SJ, Hazra A, Rosner BA, Eliassen AH, Hankinson SE, Brown M, Tamimi RM. Androgen receptor expression in normal breast tissue and subsequent breast cancer risk. NPJ Breast Cancer. 2018;4:33. PMC6155011 162. Gaudet MM, Gierach GL, Carter BD, Luo J, Milne RL, Weiderpass E, Giles GG, Tamimi RM, Eliassen AH, Rosner B, Wolk A, Adami H-O, Margolis KL, Gapstur SM, García-Closas M, Brinton LA. Pooled Analysis of Nine Cohorts Reveals Breast Cancer Risk Factors by Tumor Molecular Subtype. Cancer Res. 2018;78(20):6011-6021. PMC6223627 163. Houghton SC, Eliassen AH, Zhang SM, Selhub J, Rosner BA, Willett WC, Hankinson SE. Plasma B-vitamin and one-carbon metabolites and risk of breast cancer before and after folic acid fortification in the US. Int J Cancer. 2019;144(8):1929-1940. PMCID in progress 164. Heng YJ, Wang J, Ahearn TU, Brown SB, Zhang X, Ambrosone CB, de Andrade VP, Brufsky AM, Couch FJ, King TA, Modugno F, Vachon CM, DuPre NC, García-Closas M, Troester MA, Hunter DJ, Eliassen AH, Tamimi RM, Hankinson SE, Beck AH. Molecular mechanisms linking high body mass index to breast cancer etiology in post-menopausal breast tumor and tumor-adjacent tissues. Breast Cancer Res Treat. 2019:173(3):667-677. PMC6391202 165. Kensler KH, Poole EM, Heng YJ, Collins LC, Glass B, Beck AH, Hazra A, Rosner BA, Eliassen AH, Hankinson SE, Winer EP, Brown M, Tamimi RM. Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses' Health Studies. J Natl Cancer Inst. November 2018. doi:10.1093/jnci/djy173. [Epub ahead of print] 166. Barnard ME, Poole EM, Curhan GC, Eliassen AH, Rosner BA, Terry KL, Tworoger SS. Association of Analgesic Use With Risk of Ovarian Cancer in the Nurses' Health Studies. JAMA Oncol. 2018;4(12):1675-1682. PMC6400245 167. Barnard ME, Hecht JL, Rice MS, Gupta M, Harris HR, Eliassen AH, Rosner BA, Terry KL, Tworoger SS. Antiinflammatory Drug Use and Ovarian Cancer Risk by COX1/COX2 Expression and Infiltration of Tumor-Associated Macrophages. Cancer Epidemiol Biomarkers Prev. 2018;27(12):1509-1507. PMC6415678 168. Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, Tyrer JP, Chen T-H, Wang Q, Bolla MK, Yang X, Adank MA, Ahearn T, Aittomäki K, Allen J, Andrulis IL, Anton-Culver 30 H, Antonenkova NN, Arndt V, Aronson KJ, Auer PL, Auvinen P, Barrdahl M, Beane Freeman LE, Beckmann MW, Behrens S, Benítez J, Bermisheva M, Bernstein L, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Borresen-Dale A-L, Brauch H, Bremer M, Brenner H, Brentnall A, Brock IW, Brooks-Wilson A, Brucker SY, Brüning T, Burwinkel B, Campa D, Carter BD, Castelao JE, Chanock SJ, Chlebowski R, Christiansen H, Clarke CL, Collée JM, Cordina-Duverger E, Cornelissen S, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dork T, Santos Silva Dos I, Dumont M, Durcan L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Ellberg C, Engel C, Eriksson M, Evans DG, Fasching PA, Figueroa J, Fletcher O, Flyger H, Försti A, Fritschi L, Gabrielson M, Gago-Dominguez M, Gapstur SM, García-Sáenz JA, Gaudet MM, Georgoulias V, Giles GG, Gilyazova IR, Glendon G, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Grenaker Alnæs GI, Grip M, Gronwald J, Grundy A, Guénel P, Haeberle L, Hahnen E, Haiman CA, Hakansson N, et al. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. Am J Hum Genet. December 2018. doi:10.1016/j.ajhg.2018.11.002. [Epub ahead of print] 169. Nichols HB, Schoemaker MJ, Cai J, Xu J, Wright LB, Brook MN, Jones ME, Adami H-O, Baglietto L, Bertrand KA, Blot WJ, Boutron-Ruault M-C, Dorronsoro M, Dossus L, Eliassen AH, Giles GG, Gram IT, Hankinson SE, Hoffman-Bolton J, Kaaks R, Key TJ, Kitahara CM, Larsson SC, Linet M, Merritt MA, Milne RL, Pala V, Palmer JR, Peeters PH, Riboli E, Sund M, Tamimi RM, Tjønneland A, Trichopoulou A, Ursin G, Vatten L, Visvanathan K, Weiderpass E, Wolk A, Zheng W, Weinberg CR, Swerdlow AJ, Sandler DP. Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies. Ann Intern Med. December 2018. doi:10.7326/M18-1323. [Epub ahead of print] 170. Jiang X, Zeleznik OA, Lindström S, Lasky-Su J, Hagan K, Clish CB, Eliassen AH, Kraft P, Kabrhel C. Metabolites associated with the risk of incident venous thromboembolism: a metabolomic analysis. J Am Heart Assoc. 2018 Nov 20;7(22):e010317. PMC6404443 171. Kensler KH, Sankar VN, Wang J, Zhang X, Rubadue CA, Baker GM, Parker JS, Hoadley KA, Stancu AL, Pyle ME, Collins LC, Hunter DJ, Eliassen AH, Hankinson SE, Tamimi RM, Heng YJ. PAM50 Molecular Intrinsic Subtypes in the Nurses' Health Study Cohorts. Cancer Epidemiol Biomarkers Prev. 2019;28(4):798-806. PMCID in progress 172. Kensler KH, Eliassen AH, Rosner BA, Hankinson SE, Brown M, Tamimi RM. Pre-diagnostic sex hormone levels and survival among breast cancer patients. Breast Cancer Res Treat. 2019;174(3):749-758. PMC6446911 173. Austin AM, Kapadia NS, Brooks GA, Onega TL, Eliassen AH, Tamimi RM, Holmes M, Wang Q, Grodstein F, Tosteson ANA. Comparison of treatment of early-stage breast cancer among Nurses' Health Study participants and other Medicare beneficiaries. Breast Cancer Res Treat. 2019;174(3):759-767. PMC6440837 174. Ruth KS, Soares ALG, Borges MC, Eliassen AH, Hankinson SE, Jones ME, Kraft P, Nichols HB, Sandler DP, Schoemaker MJ, Taylor JA, Zeleniuch-Jacquotte A, Lawlor DA, Swerdlow AJ, Murray A. Genome-wide association study of anti-Müllerian hormone levels in pre- menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan. Hum Mol Genet. 2019 Jan 14. doi: 10.1093/hmg/ddz015. [Epub ahead of print] 175. Stock D, Knight JA, Raboud J, Cotterchio M, Strohmaier S, Willett W, Eliassen AH, Rosner B, Hankinson SE, Schernhammer E. Rotating night shift work and menopausal age. Hum Reprod. 2019;34(3):539-548. PMCID in progress 176. Escala-Garcia M, Guo Q, Dörk T, Canisius S, Keeman R, Dennis J, Beesley J, Lecarpentier J, Bolla MK, Wang Q, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Boeckx B, Bojesen SE, 31 Bonanni B, Børresen-Dale AL, Brauch H, Brenner H, Brentnall A, Brinton L, Broberg P, Brock IW, Brucker SY, Burwinkel B, Caldas C, Caldés T, Campa D, Canzian F, Carracedo A, Carter BD, Castelao JE, Chang-Claude J, Chanock SJ, Chenevix-Trench G, Cheng TD, Chin SF, Clarke CL; NBCS Collaborators, Cordina-Duverger E, Couch FJ, Cox DG, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dunn JA, Dunning AM, Durcan L, Dwek M, Earl HM, Ekici AB, Eliassen AH, Ellberg C, Engel C, Eriksson M, Evans DG, Figueroa J, Flesch-Janys D, Flyger H, Gabrielson M, Gago-Dominguez M, Galle E, Gapstur SM, García-Closas M, García- Sáenz JA, Gaudet MM, George A, Georgoulias V, Giles GG, Glendon G, Goldgar DE, González-Neira A, Alnæs GIG, Grip M, Guénel P, Haeberle L, Hahnen E, Haiman CA, Håkansson N, Hall P, Hamann U, Hankinson S, Harkness EF, Harrington PA, Hart SN, Hartikainen JM, Hein A, Hillemanns P, Hiller L, Holleczek B, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Howell A, Huang G, Humphreys K, Hunter DJ, Janni W, John EM, Jones ME, Jukkola-Vuorinen A, Jung A, Kaaks R, Kabisch M, Kaczmarek K, Kerin MJ, Khan S, Khusnutdinova E, Kiiski JI, Kitahara CM, Knight JA, Ko YD, Koppert LB, Kosma VM, Kraft P, Kristensen VN, Krüger U, Kühl T, Lambrechts D, Le Marchand L, Lee E, Lejbkowicz F, Li L, Lindblom A, Lindström S, Linet M, Lissowska J, Lo WY, Loibl S, Lubiński J, Lux MP, MacInnis RJ, Maierthaler M, Maishman T, Makalic E, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martinez ME, Mavroudis D, McLean C, Meindl A, Middha P, Miller N, Milne RL, Moreno F, Mulligan AM, Mulot C, Nassir R, Neuhausen SL, Newman WT, Nielsen SF, Nordestgaard BG, Norman A, Olsson H, Orr N, Pankratz VS, Park-Simon TW, Perez JIA, Pérez-Barrios C, Peterlongo P, Petridis C, Pinchev M, Prajzendanc K, Prentice R, Presneau N, Prokofieva D, Pylkäs K, Rack B, Radice P, Ramachandran D, Rennert G, Rennert HS, Rhenius V, Romero A, Roylance R, Saloustros E, Sawyer EJ, Schmidt DF, Schmutzler RK, Schneeweiss A, Schoemaker MJ, Schumacher F, Schwentner L, Scott RJ, Scott C, Seynaeve C, Shah M, Simard J, Smeets A, Sohn C, Southey MC, Swerdlow AJ, Talhouk A, Tamimi RM, Tapper WJ, Teixeira MR, Tengström M, Terry MB, Thöne K, Tollenaar RAEM, Tomlinson I, Torres D, Truong T, Turman C, Turnbull C, Ulmer HU, Untch M, Vachon C, van Asperen CJ, van den Ouweland AMW, van Veen EM, Wendt C, Whittemore AS, Willett W, Winqvist R, Wolk A, Yang XR, Zhang Y, Easton DF, Fasching PA, Nevanlinna H, Eccles DM, Pharoah PDP, Schmidt MK. Genome-wide association study of germline variants and breast cancer-specific mortality. Br J Cancer. 2019;120(6):647-657. PMCID in progress 177. Fortner RT, Sisti J, Chai B, Collins LC, Rosner B, Hankinson SE, Tamimi RM, Eliassen AH. Parity, breastfeeding, and breast cancer risk by hormone receptor status and molecular phenotype: results from the Nurses' Health Studies. Breast Cancer Res. 2019 Mar 12;21(1):40. PMC6416887 178. Clendenen TV, Ge W, Koenig KL, Afanasyeva Y, Agnoli C, Brinton LA, Darvishian F, Dorgan JF, Eliassen AH, Falk RT, Hallmans G, Hankinson SE, Hoffman-Bolton J, Key TJ, Krogh V, Nichols HB, Sandler DP, Schoemaker MJ, Sluss PM, Sund M, Swerdlow AJ, Visvanathan K, Zeleniuch-Jacquotte A, Liu M. Breast cancer risk prediction in women aged 35-50 years: impact of including sex hormone concentrations in the Gail model. Breast Cancer Res. 2019 Mar 19;21(1):42. PMC6425605 179. Johnson CY, Tanz LJ, Lawson CC, Howards PP, Bertone-Johnson ER, Eliassen AH, Schernhammer ES, Rich-Edwards JW. Anti-Müllerian hormone levels in nurses working night shifts. Arch Environ Occup Health. 2019 Apr 4:1-8. [Epub ahead of print]

Reviews, Chapters, Monographs and Editorials 32 1. Hankinson SE, Eliassen AH. Endogenous estrogen, testosterone and progesterone levels in relation to breast cancer risk. J Steroid Biochem Mol Biol. 2007;106(1-5):24-30. PMC2715949 2. Eliassen AH, Hankinson SE. Endogenous hormone levels and risk of breast, endometrial and ovarian cancer: prospective studies. In: Innovative Endocrinology of Cancer, Berstein LM and Santen RJ, eds. Landes Bioscience, New York;2008:148-65. 3. Hankinson SE, Eliassen AH. Circulating sex steroids and breast cancer risk in premenopausal women. Horm Cancer 2010;(1):2-10. PMC3253362 4. Faupel-Badger JM, Arcaro KF, Balkam JJ, Eliassen AH, Hassiotou F, Lebrilla CB, Michels KB, Palmer JR, Schedin P, Stuebe AM, Watson CJ, Sherman ME. Postpartum Remodeling, Lactation, and Breast Cancer Risk: Summary of a National Cancer Institute-Sponsored Workshop. J Natl Cancer Inst. 2013;105(3):166-74. PMC3611853 5. Willett WC, Tamimi RM, Hankinson SE, Hazra A, Eliassen AH, Colditz GA. Nongenetic Factors in the Causation of Breast Cancer. In: Diseases of the Breast, 5th Edition. Harris JR, Morrow M, Lippman ME, Osborne CK, eds. Wolters Kluwer 2014: Ch. 18:211 6. Keum N, Song M, Giovannucci EL, Eliassen AH. Obesity and Body Composition. In: Schottenfeld and Fraumeni, Cancer Epidemiology and Prevention, 4th Edition. Cerhan JR, Haiman C, Linet MS, Thun MJ, eds. Oxford University Press 2017. Chapter 20. 7. Lasky-Su JA, Zeleznik OA, Eliassen AH. Using metabolomics to explore the role of postmenopausal adiposity in breast cancer risk. J Natl Cancer Inst. 2018;110(6):547–548. 8. Brantley KD, Hankinson SE, Eliassen AH. Hormones and Cancer. In: Encyclopedia of Cancer, 3rd Edition. Boffetta P, Hainaut P, eds. Academic Press 2018.

Letters to the Editor 1. Kim EH, Hankinson SE, Eliassen AH, Willett WC. A prospective study of grapefruit and grapefruit juice intake and breast cancer risk [Letter]. Br J Cancer. 2008;98(1):240-1. PMC2359690

Thesis 1. Eliassen AH. Reproductive and Lifestyle Correlates of Prolactin Levels [Master’s Thesis]. Boston, MA: Harvard T.H. Chan School of Public Health; 2001. 2. Eliassen AH. Lifestyle Factors and Risk of Breast Cancer [Doctoral Thesis]. Boston, MA: Harvard T.H. Chan School of Public Health; 2004.

Narrative Report My research focuses on the associations between lifestyle factors, biomarkers of lifestyle and hormones, and breast cancer risk. I have studied ways women may alter their lifestyle to reduce breast cancer risk, using data from the NHS and NHSII cohorts. I have obtained funding from the NIH and Komen Foundation as an independent investigator, with a focus on carotenoids, oxidative stress, metabolomics, and breast cancer risk. My main administrative responsibilities include serving as co-PI of the NHSII cohort and as Director of the BWH/Harvard Cohorts Biorepository. The remainder of my time is spent teaching and mentoring.

In my study of potentially preventive lifestyle factors, I showed that weight loss and increased physical activity after menopause reduced breast cancer risk. As chair of an international collaborative group, I led a pooled analysis of 8 cohort studies and showed that higher blood levels of carotenoids, prominent in 33 fruits and vegetables, significantly reduced breast cancer risk. As a result, I obtained an NIH R01 to continue studying carotenoids and explore the role of oxidative stress in breast cancer etiology. In an analysis of a biomarker for oxidative stress, we showed oxidative stress may not be an important factor in the relation between carotenoids and breast cancer risk. However, in a more in-depth examination of carotenoids and breast cancer risk, I observed a significantly lower risk of lethal/recurrent breast cancer with higher carotenoid levels. Continuing the examination of biomarkers that reflect both diet and endogenous synthesis and breast cancer risk, I am investigating the role of circulating fatty acids and breast cancer risk by tumor expression of inflammatory and immune markers, and am co-PI of the main scientific R01 of the NHSII cohort, in which we are investigating metabolomics and breast cancer risk.

I also have expanded our understanding of the role of hormones in breast cancer etiology, and the intersection between hormones and lifestyle factors. I led the first extensive analysis of urinary estrogen metabolites with risk of breast cancer in premenopausal women, finding unexpected inverse associations. Building upon these findings, I have overseen several analyses to understand how lifestyle factors may impact patterns of estrogen metabolism.

As the co-PI of NHSII, I have multiple leadership responsibilities. Locally, I serve as a senior scientific resource to others wishing to collaborate, help determine the scientific direction of the study, and lead students in their analyses of lifestyle factors and biomarkers in relation to breast cancer risk. I also have represented the cohort nationally and internationally. My reputation in the breast cancer research community has led to invitations to serve on several grant study sections, including the DoD, and to give talks at NCI seminars and workshops. Our infrastructure grant renewal application (U01 CA176726), on which Dr. Willett and I serve as multi-PIs, was reviewed in July 2017 and received a perfect priority score of 10 and is currently funded.

I am active in teaching and mentoring at the Harvard Chan School, including as the primary instructor for Epi 246: Applied Biomarkers in Cancer Epidemiology. I mentored two masters and two doctoral students in Epidemiology (Harvard Chan School) and three post-doctoral fellows as they conducted epidemiologic research. I currently mentor one masters student and one doctoral student in Epidemiology and two postdoctoral fellows. I also serve on oral exam and thesis committees for eight (seven past, one current) doctoral students.

Through contributions to the framework of the NHS/NHSII cohorts, directing the BWH/Harvard Cohorts Biorepository, applying the data obtained to study lifestyle factors and breast cancer etiology, collaborating with others in the field, and mentoring younger researchers, I intend to continue making meaningful contributions to the field of breast cancer epidemiology.

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