Radical Hysterectomy for Carcinoma of the Cervix*
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Radical Hysterectomy for Carcinoma of the Cervix* JOHN J. MIKUTA. M.D. Department of Obstetrics and Gynecology. Division of Gynecologic Oncology, Hospital of the University of Pennsylvania School of Medicine. University of Pennsylvania. Philadelphia. Pennsylvania Radical hysterectomy refers to the removal of chemotherapy. and improvement in pre and the uterus and cervix and, in addition, to the removal postoperative care. Between 1939 and 1951, Meigs of the upper one-half to one-third of the vagina. the performed I 00 consecutive radical hysterectomy parametria and the pelvic lymph nodes. This opera operations without a single surgical mortality. This tion, which is commonly called the Wertheim opera astounding feat provided the impetus in the United tion. was actually first described by Clark in the States for a revision of thinking about this procedure United States and Ries in Germany. Wertheim's in the post-World War II era. original operation for carcinoma of the cervix con Meigs also defined the advantages of utilizing sisted only of a partial parametrial removal and radical hysterectomy in preference to radiation removal of the upper one-third of the vagina. It did therapy for cervical cancer. These are as follows: not include pelvic lymphadenectomy or the removal I. There can be no tumor recurrence in the of the lateral portions of the parametria. cervix itself. The early efforts at radical hysterectomy for cer 2. There can be no new tumor growths in the vical cancer resulted in operative and surgical mor cervix or upper vagina. tality in the range of 25-75%. In 1903. when it 3. The problem of radio-resistant tumors is became obvious that radiation therapy. available avoided. then only in the form of radium, was effective for the 4. There can be no radiation injuries to the control of cervical cancer. clinicians abandoned the bowel or the bladder. radical hysterectomy procedure in favor of this In addition to the advantages listed by Meigs. limited form of radiation. A few individuals persisted two other important factors can be considered as in performing the operation, and in I 935. the British helpful. The first of these is the ability to preserve gynecologist and surgeon, Victor Bonney, reported ovarian function in young women. The incidence of on 500 consecutive patients on whom he had done metastasis to the ovary in a patient with early car radical hysterectomy. His operative mortality was cinoma of the cervix is negligible, and it is possible. 16%. by using radical surgery to preserve at least one In 1939, Dr. Joseph Meigs of Boston decided to ovary. to avoid the onset of the climacteric. The sec take a second look at the radical hysterectomy ond aspect is that the gynecologic oncologist will procedure in view of some of the technical advances know the extent of the disease as reported to him by which had occurred in medicine, primarily in the the pathologist after thorough study of the removed areas of blood transfusion, anesthesia, antibacterial specimen. From this not only will the prognosis be known but also additional therapy can be considered. * Presented by Dr. Mikula at the 46th Annual McGuire Lec ture Series. December 6. 1974. at the Medical College or Virginia. Also. there are several clinical situations in Richmond. which. given equally available expert radiation MCV QUARTERLY 11(1):41-44, 1975 41 M!KUTA: RADICAL HYSTERECTOMY 42 therapy and radical pelvic surgery personnel and resident to develop the necessary skills. Similarly, in facilities. one might elect a radical hysterectomy the routine practice of gynecology. a physician will approach. These are as follows: not have sufficient numbers of such patients to main tain his operative expertise and capability. This I. Previous pelvic surgery (supravaginal or limitation is gradually being overcome by the total hysterectomy) development of training programs in gynecologic on 2. Presence of adnexal mass or masses. or cology which include training in the performance of previous pelvic inflammatory disease radical pelvic procedures. The identification and 3. Diabetes mellitus utilization of the gynecologic oncologist who can per 4. Pregnancy form such procedures and who limits his area of 5. Radiophobia specialization to the treatment of gynecologic cancer Appreciating what has already been stated with and its problems. is now a reality. A certifying board regard to the advantages as well as the indications for in gynecologic oncology has been developed and in the use of radical hysterectomy and pelvic dividuals are being recognized for skill in this par lymphadenectomy. there are three significant limiting ticular area. In addition. training programs are now features: available throughout the country for individuals I. The medical condi1ion of 1he pa1ie111. This is already qualified in obstetrics and gynecology. They primarily related to the patient's general condition. can receive additional training for two years to her age. obesity. and the presence of underlying car develop these skills. diovascular and other diseases which might inlluence Let us turn to some of the improvements which the development of signiticant operative and have occurred in the results with radical hysterec postoperative complications. tomy in the management of cervical carcinoma. As 2. The 1ype and e.\"lenl of 1he malignancy 11·hic/1 is mentioned earlier. the operative and surgical mortali being 1rea1ed. In cervical carcinoma. one of the ty was one of the major limiting factors in this limiting factors is the extent of the disease and the procedure. Since Meigs· original series. other writers degree of its parametrial infiltration. From a clinical in recent times have reported series or patients on standpoint. cancers of the cervix favorable for a whom radical hysterectomy was carried out with radical hysterectomy are clinical Stage 1-a. minimal minimal mortality. The inevitable catastrophe will to moderate-siLed lesions which are 1-b. or very early occur from time to time when the surgeon. at times Stage II-a or Stage 11-b tumors. More extensive local overstepping the bounds of good judgement. under disease increases the probability of inadequate sur takes radical pelvic surgery on a patient and has an gery as well as the risk of cutting through the tumor unfavorable result. In general. the operative and sur at the time of operation. Similarly. the presence or gical mortality should be in the range of 0.5%. any tumor which is spread beyond the pelvic area in Scrupulous attention must be given to the the abdomen. particularly lymphatic involvement of thorough preoperative evaluation of the patient. not the para-aortic nodes or liver. is considered a con unly from the standpoint of her disease process so traindication to radical hysterectomy approach as is that an operation of this type will not be attempted the finding of any distant metastasis during the on a patient with distant metastatic disease. but also preoperative oncologic evaluation. Finally. radical attention must be given to the general physical condi hysterectomy may be utiliLed in patients "ho have tion of the patient. primarily her cardiovascular. minimal. central. post-radiation recurrence in which pulmonary. and renal systems. Infection of the the lesion has not extended to the bladder and rec urinary system must be brought under control prior tum. This operation. under proper circumstances. is to surgery. The operation itself must be meticulously preferable to the more extensive and complicated carried out with the knowledge of the extent or the procedure of pelvic exenteration. operation, the patient's condition. and possible 3. The auailabilily of a surgeon 10 pe1fom1 radical complicating factors well known to a competent hysleree/omy. This factor in general provides the medical anesthesiologist. Careful dissection or the greatest limitation to the surgical approach. since pelvis with specific care around the large vessels during the standard gynecologic residency program. and ureters will insure a much lower incidenct: or there is neither the time nor the experience available significant vascular and urinary tract complications in the performance of radical pelvic surgery for the which are the chid" intra-operative problems. Finally. MIKUTA: RADICAL HYSTERECTOMY 43 careful attention to the details of postoperative care has been the practice at the Hospital of the University are essential to avoid the problems associated with of Pennsylvania to evaluate the bladder prior to and pulmonary, bowel, and urinary areas and to reduce after operation by the use of cystometry. A the incidence of thromboembolic phenomena in these baseline measurement of bladder function is ob patients. For more detailed descriptions of these tained prior to surgery, and, on approximately day 9 areas of importance in the pre and postoperative or 10 following surgery, a repeat cystometric evalua care, one's attention is directed to Nelson's Atlas of tion is carried out. Frequently the bladder will be Radical Pelvic Surgery.* found to be of the autonomous neurogenic type, The major problem creating morbidity with where there is absence of the sensation of filling as radical hysterectomy for cervical carcinoma is well as failure of the bladder to accommodate to fill associated with the urinary tract. While Meigs listed ing. If attention is not paid to this alteration in vesical among the advantages of radical hysterectomy the function, the result will be overdistention and avoidance of radiation complications to the bowel overflow incontinence. Generally by the 10th to 20th and bladder, it became evident that there was a day after surgery there will be a gradual return of significant morbidity associated with these structures function toward normal, first with the return of the from radical hysterectomy. In reviewing all of the sensation of filling and the desire to void, and later a complications associated with radical hysterectomy correction of the detrusor function where accom at the Hospital of the University of Pennsylvania.