Hyperactivity Disorder
Molecular Psychiatry (2011) 16, 491–503 & 2011 Macmillan Publishers Limited All rights reserved 1359-4184/11 www.nature.com/mp ORIGINAL ARTICLE Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree K-P Lesch1,6, S Selch1,6, TJ Renner2,6, C Jacob1, TT Nguyen3, T Hahn1, M Romanos2, S Walitza2, S Shoichet4, A Dempfle3, M Heine1, A Boreatti-Hu¨mmer1, J Romanos1, S Gross-Lesch1, H Zerlaut3, T Wultsch1, S Heinzel1, M Fassnacht5, A Fallgatter1, B Allolio5, H Scha¨fer4, A Warnke2, A Reif1, H-H Ropers4 and R Ullmann4 1ADHD Clinical Research Network, Unit for Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany; 2ADHD Clinical Research Network, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany; 3Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany; 4Max Planck Institute for Molecular Genetics, Berlin, Germany and 5Department of Endocrinology and Diabetes, Internal Medicine I, University of Wuerzburg, Wuerzburg, Germany Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelop- mental syndrome characterized by hyperactivity, inattention and increased impulsivity. To detect micro-deletions and micro-duplications that may have a role in the pathogenesis of ADHD, we carried out a genome-wide screen for copy number variations (CNVs) in a cohort of 99 children and adolescents with severe ADHD. Using high-resolution array comparative genomic hybridization (aCGH), a total of 17 potentially syndrome-associated CNVs were identified. The aberrations comprise 4 deletions and 13 duplications with approximate sizes ranging from 110 kb to 3 Mb.
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