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Prof. DR. SYED ABID ALI

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Prof. DR. SYED ABID ALI Prof. DR. SYED ABID ALI M.Sc. Biochemistry/Mol. Biology (QAU), Ph.D. Protein Chemistry (KU) PostDoc's. Protein Science/Proteomics (Germany, UK, Australia) PostDoc's. Protein Science/Proteomics (Germany, UK, Australia) HEC, DAAD & Alexander von Humboldt Fellow H.E.J. Research Institute of Chemistry, ICCBS, University of Karachi, Karachi-75270, Pakistan. +92-21-99261720 Associate +92 - Professor21 - 34819018 Biochemistry,-19 ICCBS, HEJ +92-333-3456872 www.iccs.edu_hej [email protected] ; [email protected] Area of Excellence Profile Summary An enthusiastic, creative and passionate educator, mentor and advisor with strong scientific skills and added industry exposure who believes that all students can Teaching & Research learn and thrive in a learning environment that is stimulating, comforting and appropriate to their unique talents and capabilities. Research Supervisor Research interest areas are Protein Biochemistry, Proteomics, Toxicogenomics, Bio/Nanotechnology, Bioinformatics, and Environmental Microbiology. Biotech/Pharma- Industry Research focus on purification and characterization of novel proteins (e.g. industrially & medicinally important proteins/enzymes) and peptides (e.g. peptidyl Reviewer of Journals modulators of ion channels and peptidyl antibiotics) from diverse origin such as; microorganism (Enterococcus, Pseudomonas & Penicillium sp), medicinally important plant (Salvadora, Sida and Quinoa sp) and venomous fauna of Pakistan Protein Chemistry/ (Snake, Scorpion, Jellyfish, Conus and Centipedes etc). Proteomics Venomics/Toxinology Additionally, my research is inherently interdisciplinary integrating ecology, protein biochemistry, functional genomics/proteomics and pharmacological approaches to understand protein/peptide function and their various applications. Biotechnology/ Bioinformatics Technical expertise in the structure-function relationship of proteins and peptides using Edman degradation in combination of 1D/2D PAGE, mass spectrometry Conference/Seminars (MALDI TOF MS and LC-MS/MS) with special emphasis on protein aggregation, folding/unfolding kinetics, protein-protein and protein-peptide interactions and Organizer protein conformational studies using spectroscopic (UV/Vis, FR, CD, FTIR, SAXS, Collaboration & DSC, DLS) and various proteomics/bioinformatics tools. Coordination Education Postdoc 4 Venom Evolution Lab., University of Queensland, Australia, 2012-13 Postdoc 3 Inst. Physiol. Chem., University of Tuebingen, Germany, 2005-06;2008 Postdoc 2 Center for Medical Research (ZMF), University of Tuebingen, Germany, 2002 Postdoc 1 Dept. Physical Biochemistry, University of Tuebingen, Germany, 97-2000 Ph.D (Biochemistry/Protein chemistry), HEJ, ICCBS, University of Karachi, 1997 M.Sc. (Biochemistry/Mol. Biology), Quaid-e-Azam University, Islamabad,1991 B. Sc. (Chemistry, Microbiology & Botany), D.J. Science college, Karachi, 1988 Career Timeline Jr./Sr. Research Postdoctoral Research Postdoctoral Research Assistant Professor Professor Fellow, ICCBS DAAD fellow AvH Fellow, Germany H.E.J. RIC, ICCBS H.E.J. RIC, ICCBS Germany Germany Germany Jan 2017 1991-1997 1997-1998 1997-2000 2001-2002 2005-2008 2012-2013 2003-2013 2013-2016 till date Postdoctoral HEC PD Fellow Associate Professor Visiting Scientist UK Research fellow Visiting Academic H.E.J. RIC, ICCBS Germany Australia Work Experience Jan 2017 - till date Professor (BPS - 21) Biochemistry: Protein Chemistry International Centre for Chemical & Biological Sciences HEJ Research Institute of Chemistry University of Karachi, Karachi-75270, Pakistan July 2013 - Dec 2016 Associate Professor (BPS - 20) Biochemistry: International Centre for Chemical & Biological Sciences HEJ Research Proteomics, Peptidomics Institute of Chemistry University of Karachi, Karachi-75270, Pakistan Protein Structure-Functions Experimental Research (70%) Relationship, Environmental Teaching: Ph.D programs in Biochemistry (20%) Microbiology, Biotechnology etc. Advance courses: Protein structure function relationship, architecture, classification and Physical Biochemistry Advance practical course: on Protein structure and function Admin Work (10%) Jan 2003 – June 2013 Assistant Professor (BPS - 19) Biochemistry: Protein Chemistry, International Centre for Chemical & Biological Sciences HEJ Research Bioinformatics etc. Institute of Chemistry University of Karachi, Karachi-75270, Pakistan Same as above June 2012 – March 2013 Visiting Academics (HEC, Postdoctoral fellow) Toxicogenomics, Venomics Venom Evolution Laboratory, School of Biological Sciences, antivenomics, Protein evolution University of Queensland, St Lucia, QLD-4072 Australia Physio-Pharmacology etc. Supervision of: Prof. Dr. Bryan G Fry April – June 2008 Postdoctoral Research (AvH Fellow) March 2006 - April 2005 Visiting Academics Molecular Parasitology: Interfakultäres Institut für Biochemie Molecular biology, Cell culture etc. University of Tuebingen, Hoppe-Seyler Str. 4, D-72076, Tuebingen, Germany Supervision of: Prof. Dr. Michael Duszenko Aug – Sep 2003 Visiting Scientist Molecular Parasitology: Molecular Parasitology laboratory, Institute of Physiological Chemistry, PCR, Gene Sequencing, University of Tuebingen, D-72076 Tuebingen, Germany Bioinformatics Supervision of: Prof. Dr. Michael Duszenko March 2001 – Dec 2002 Postdoctoral Research (Bat-IIa) Molecular mechanism of Co-culture, Center for Medical Research (ZMF), Cell culture, Wound healing etc. Department of Transfusion Med, University Kilinic Tuebingen, Waldhörnle Str. 22, D-72072 Tuebingen, Germany Supervision of: PD Dr. S. Wagner; PD Dr. B. Neumeister April 1997 – Dec 2000 Postdoctoral Research (DAAD Fellow, FRG) Physical Biochemistry: Dept. of Physical Biochemistry, Institute of Physiological Chemistry, Peptide Synthesis, Folding University of Tuebingen, Hoppe-Seyler Str. 4, Unfolding Kinetics, Stability etc. D-72076 Tuebingen, Germany Supervision of: Prof. Dr. Dr. h.c. mult Wolfgang Voelter; PD Dr. Stanka Stoeva Aug – Oct 1997 Visiting Scientist: Aug 1998 Molecular Biophysics Group, Daresbury Laboratory Daresbury, Cheshire, Biophysics (Protein in - solution) Warrington WA4 4AD, UK SAXS, Spectroscopy etc. Supervision of: Prof. Dr. S. Samar Hasnain; Dr. J.G. Grossmann Jr. to Sr. Research Fellow April 1991 – March 1997 HEJ Research Institute of Chemistry, ICCBS, University of Karachi, Karachi- Protein Chemistry (Protein 75270, Pakistan purification, Protein Sequencing, Supervision of: Prof. Dr. Atiya Abbasi; Prof. Dr. Zafar H Zaidi (Late) Mass Spectrometry etc.) Research Projects Submitted/ Ongoing/Accomplished 14. 2019 - Awarded 5.74 million Rs. Therapeutic Enzyme Collagenase: Nano-Formulations and their Higher Education Commission Stability Studies for Novel Dosage Forms. (Principle (HEC) Pakistan Investigator) 13. 2015 – 2018 Snake venom proteomics and antivenomics: A pharmacological Higher Education Commission 11.073 million Rs. biodiversity hotspot and dire national need to save lives. (Principle Investigator) (HEC) Pakistan 12. 2015 93,500 Rs. Competitive grant for the maintenance/ upgradation of scientific Higher Education Commission equipment. (Principle Investigator) (HEC) Pakistan The Use of the Rabbit Intestinal nerve muscle preparation to 11. 2014-2015 75,000 Rs. assess the protective activity of Indian Polyvalent antivenom on Dean Faculty of Science, neuromuscular system. (Co Principle Investigator) University of Karachi Marine Gastropods: Species identification, chemotaxonomy and 10. 2011-2014 1.5 million Rs biochemical characterization of medically important proteins Pakistan Science Foundation Hemocyanin. (Principle Investigator) (PSF) Islamabad Molecular assessment of virulence determinants, antibiotic 3.6 million Rs. resistance and bacterial antagonism in environmental isolates of 9. 2010-2014 Enterococcus species. (Principle Investigator) Higher Education Commission (HEC) Pakistan 70,000 Rs. Responses of snake venoms on intestinal smooth muscles of 8. 2010 -2011 Rabbit/Rats. (Co Principle Investigator) Dean Faculty of Science, University of Karachi Screening, production and structure function-relationship of 7. 2007-2010 3.4 million Rs. lipase(s) from thermophilic bacteria. (Co Principle Higher Education Commission Investigator) (HEC) of Pakistan Concentrations of proteins, Vitellogenin, Vitellin and lipids in the 6. 2006-2009 2.01 million Rs. hepatopancreas, hemolymph, adipose tissue and ovaries during Higher Education Commission ovarian development in Penaeid Shrimps (F. Penicillatus & F. (HEC) of Pakistan Merguiensis). (Co Principle Investigator) 5. 2006 - 2007 Peptidyl inhibitors of various ion channels from snake and Alexander von Humboldt 20,845 € scorpion venoms: A possible template for drug design. Foundation, Bonn-Germany (Principle Investigator) 4. 2006-2007 Screening, production and structure-function relationship of RG Pharmaceutica (Pvt) Ltd., 0.2 million Rs. enzyme Lactases. (Principle Investigator) Karachi, Pakistan Received competitive grants from HEC for purchase of spare 3. 2004 & 2007 60,000 & 98,000 Rs. parts. (Principle Investigator) Higher Education Commission (HEC) Pakistan Peptidyl antibiotics: structure-function relationship of the 2. 2004 -2007 antimicrobial peptides and bacteriocins/lantibiotics from Higher Education 1.45 million Rs Indigenous Entrococci. (Principle Investigator) Commission (HEC) Pakistan Snake venom peptides as possible candidates for drug design 1. 2004-2005 against pathogenic Trypanosoma bruci, a causative agent of The Academy of Sciences for 5,000 $ sleeping sickness. (Principle Investigator)
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