Online Congress Scientific 15–18 March 2021 Program

20th Biennial Meeting of SFRR International

SFRR-I 2021 sfrri2021.com Agenda Monday Scientific 15 March 2021 Program

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08.45 – 09.00 Opening Ceremony Giovanni E. Man, Juan Sastre & José Viña

09.00 – 11.00 Symposium 1 Relevance of Oxygen Levels for Stem Cell Redox Biology and Regenerative Medicine

Chairs: Giovanni E. Mann King’s British Heart Foundation Centre of Excellence, Faculty of Life Sciences & Medicine, King’s College London, London, UK

José Viña Freshage Research Group Department of Physiology. University of Valencia, Spain

Cellular redox signaling under physiological normoxia and ischemia- reperfusion Giovanni E. Mann King’s British Heart Foundation Centre of Excellence, Faculty of Life Sciences & Medicine, King’s College London, London, UK

Transcriptomic and proteomic characterization of human cardiac progenitor cells Maria J. Sebastião Animal Cell Technology Unit, iBET Instituto de Biologia Experimental e Tecnológica, Portugal

Relevance of oxygen concentration in stem cell culture for regenerative medicine Consuelo Borras Freshage Research Group- Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain

Do hypoxia mimetic agents’ provide fidelity in replication of engineered oxygen control measures in human mesenchymal stem cell isolation and culture? Nicholas R. Forsyth School of Pharmacy and Bioengineering, Keele University

Break 30 min Agenda Monday Scientific 15 March 2021 Program

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11.30 – 12.30 Trevor Slater Award Lecture

Chairs: Daniela Caporossi University of Rome Foro Italico. Rome. Italy

José Viña Freshage Research Group Department of Physiology. University of Valencia. Spain

A redox-centred view of skeletal muscle responses to exercise and ageing Malcolm Jackson Institute of Ageing and Chronic Disease, University of Liverpool, UK

12.30 – 13.30 Oral Comunications 1 Narrated Communications

Chairs: Nesrin Kartal-Özer Chairs: Corinne Spickett Department of Biochemistry. Biosciences Research Group. Faculty of Medicine. Marmara Aston University. UK University. Istanbul. Turkey Osamu Handa Lars Oliver-Klotz Department of Gastroenterology Institute of Nutritional Sciences. and Hepatology. Kyoto Prefectural Jena. Germany University of Medicine

OP1 – OP4 Discussion Session 1 NC1 – NC11

Break 1 hour

14.30 – 16.00 Narrated Communications Narrated Communications

Chairs: Pablo Evelson Chairs: Patricia Oteiza Universidad de Buenos Aires. University of California Davis. Davis. Facultad de Farmacia y USA Bioquímica. Departamento de Química Analítica y Fisicoquímica. Francisco Laurindo Cátedra de Química General Vascular Biology Laboratory. e Inorgánica. Buenos Aires. University of São Paulo Argentina. CONICET - Universidad de Buenos Aires. Instituto de Bioquímica y Medicina Molecular Discussion Session 3 (IBIMOL). Buenos Aires. Argentina. NC30 – NC44

Christian González Departamento de Biología. University of Chile

Discussion Session 2 NC12 – NC29 Agenda Monday Scientific 15 March 2021 Program

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16.00 – 18.00 Symposium 2 Symposium 3 Precision Redox and Mitochondrial Revising Redox Biology: New insights from Quality in Aging Selenium

Chair: Chang Chen Chairs: Xingen Lei Institute of Biophysics, Chinese Cornell University, USA Academy of Sciences, Beijing, China Yongping Bao University of East Anglia, UK

Redox-stress response capacity decline and ER reductive stress in aging New functions of selenoproteins: beyond Chang Chen redox reactivity Institute of Biophysics, Chinese Academy Xingen Lei of Sciences, Beijing, China Cornell University, USA

Relative importance of human and mouse Mitochondrial H2O2: new insights from selenoproteins imaging Vadim Gladyshev Vsevolod Belousov Brigham and Women’s Hospital, Harvard Department of Metabolism and Redox Medical School, Boston, USA Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russia The molecular underpinnings of selenium in ferroptosis Mitochondrial transport and energy Marcus Conrad homeostasis in neuronal degeneration Institute of Developmental Genetics, and regeneration Helmholtz Zentrum München, Germany Zu-Hang Sheng Synaptic Function Section, NINDS, NIH, USA The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth Age and sex determine the effectiveness factor responses of redox adaptive homeostasis Elias Arnér Kelvin J. A. Davies Department of Medical Biochemistry and Leonard Davis School of Gerontology Biophysics (MBB). Karolinska Institutet, of the Ethel Percy Andrus Gerontology Stockholm, Sweden Center, University of Southern California, Los Angeles, USA

18.00 – 18.30 SFRR-I Executive Committee Meeting Agenda Tuesday Scientific 16 March 2021 Program

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09.00 – 11.00 Symposium 4 Role of Redox-active Metals for the Prevention and Treatment of Cancer in the Era of Precision Medicine

Chairs: Shinya Toyokuni Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Japan

Des R. Richardson Pathology and Bosch Institute, University of Sydney, Australasia

Role of ferroptosis in carcinogenesis and tumor biology Shinya Toyokuni Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Japan

Targeting cellular signalling to inhibit tumour cell metastasis and growth: The iron and NDRG1 connection Des R. Richardson Pathology and Bosch Institute, University of Sydney, Australasia

Anticancer platinum and gold compounds with thiol-targeting mechanisms of action Chun-Nam Lok Department of Chemistry and Chemical Biology Center, The University of Hong Kong, Hong Kong

Nanochelator of iron for improved iron removal efficacy in various disease models Guangjun Nie National Center for Nanoscience and Technology, China

Break 30 min Agenda Tuesday Scientific 16 March 2021 Program

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11.30 – 12.30 Oral Comunications 2 Oral Comunications 3

Chairs: María Monsalve Chairs: Tilman Grune Institute of Biomedical Research Department of Physiological “Alberto Sols”. CSIC-UAM. Madrid. Chemistry and Cellular Spain Biochemistry. Faculty of Chemistry. University of Vienna Fabio Virgili Centro Ricerche Alimenti e Clare L. Hawkins Nutrizione. Consiglio Nazionale Department of Biomedical per la Ricerca e Sperimentazione Sciences. University of in Agricoltura e l’Economia Copenhagen. Copenhagen. Agraria. Roma Denmark

OP5 – OP8 OP9 – OP12

Break 1 hour

13.30 – 15.00 Narrated Communications Narrated Communications

Chairs: Giuseppe Valacchi Chairs: Henry Forman Dep.t of Neuroscience and Leonard Davis School of Rehabilitation. University of Gerontology. Los Angeles. CA Ferrara. Ferrara. Italy. Joao Laranjinha Florian Gruber Center for Neurosciences and Department of Dermatology. Cell Biology. Faculty of Pharmacy. Medical University of Vienna University of Coimbra. Portugal

Discussion Session 4 Discussion Session 5 NC45 – NC63 NC64 – NC81

15.00 – 16.00 Keynote Lecture I A mitochondrial etiology of complex diseases Douglas Wallace The Center for Mitochondrial and Epigenomic Medicine at Children’s Hospital of Philadelphia, Philadelphia, USA Agenda Tuesday Scientific 16 March 2021 Program

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16.00 – 18.00 Symposium 5 Symposium 6 Redox Regulation of the Epigenetic Nutrition and redox signaling Landscape

Chairs: Cesar Fraga Chair: Frederick Domann Fisicoquímica, Facultad University of Iowa, USA de Farmaciay Bioquímica, Universidad de Buenos Aires (UBA); and Instituto de Epigenetics, the third pillar of nitric oxide Bioquímicay Medicina Molecular signalling (IBIMOL), UBA-CONICET, Buenos Douglas Thomas Aires, Argentina. Pharmaceutical Sciences, University of Illinois at Chicago, USA José Viña Freshage Research Group Redox-dependent regulation of Department of Physiology. chromatin methylation University of Valencia, Spain Alison Brewer Department of Cardiology, King’s College London, UK Relevance and bioactivity of flavonoids as regulators of redox signalling Regulation of labile Fe(II) and further DNA/ Cesar Fraga histone demethylation by cAMP signaling Fisicoquímica, Facultad de Farmaciay Gaofeng Wang Bioquímica, Universidad de Buenos Aires Department of Human Genetics, (UBA); and Instituto de Bioquímicay University of Miami Miller School of Medicina Molecular (IBIMOL), UBA-CONICET, Medicine, USA Buenos Aires, Argentina.

Maternal exposure to a mitochondrial Exercise as an antioxidant supplement to toxicant results in life-long alterations in promote healthy ageing and delay frailty the epigenetic landscape of the offspring José Viña Janine Santos Freshage Research Group Department of National Institutes of Health, USA Physiology. University of Valencia, Spain

Ketogenic diets, nutrient signaling and mitochondria Jon Ramsey Veterinary Medicine Department of Molecular Biosciences, University of California, USA

Zinc and redox signaling: impact on brain development and function Patricia Oteiza Departments of Nutrition and of Environmental Toxicology, University of California, Davis, USA Agenda Wednesday Scientific 17 March 2021 Program

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09.00 – 11.00 Symposium 7 Symposium 8 Redox regulation: Thiols, novel roles and Regulation of Redox Signaling by Nrf2 in novel thiols Health and Disease

Chair: Ivan Gout Chair: Young-Joon Surh Department of Structural and Tumor Microenvironment Global Molecular Biology, University Core Research Center, Seoul College London, UK National University, Korea

Ergothioneine, a thiol/thione antioxidant Nrf2 interacts with STAT3 and induces IL-23 with therapeutic potential expression in breast cancer Barry Halliwell Young-Joon Surh Office of the Senior Deputy President and Tumor Microenvironment Global Core Provost, National University of Singapore, Research Center, Seoul National University, Singapore Korea

The emerging role of coenzyme A and Cytoprotective function of NRF2 and its role protein CoAlation in redox regulation in sulfur metabolism Ivan Gout Hozumi Motohashi Department of Structural and Molecular Department of Gene Expression Regulation, Biology, University College London, UK Division of Aging Science, Institute of Development, Aging and Cancer, Tohoku The role of glutathione in bacterial University, Japan virulence Yunn Hwen Gan Targeting Keap1/Nrf2 as a strategy to break Department of Biochemistry, National the vicious cycle of oxidative stress – University of Singapore, Singapore inflammation – cell death Albena T. Dinkova-Kostova Human peroxiredoxin 3: oxidizing Jacqui Wood Cancer Centre, Division of substrate specificity, glutathionylation Cellular Medicine, University of Dundee and other oxidative post-translational School of Medicine, Dundee, DD1 9SY, modifications Scotland, United Kingdom Madia Trujillo Departamento de Bioquímica and ROS signalling and Nrf2-mediated adaptive Centro de Investigaciones Biomédicas, response in type 2 diabetes Facultad de Medicina,Universidad de la Jingbo Pi República, Uruguay School of Public Health, China Medical University, China

Break 30 min

11.30 – 12.30 Keynote Lecture II

Chairs: Michael Davies Department of Biomedical Sciences. Uniersity. of Copenhagen. Denmark

Giovanni E. Mann King’s British Heart Foundation Centre of Excellence. Faculty of Life Sciences & Medicine. King’s College London. London. UK

Oxidative eustress and oxidative distress Helmut Sies Institute for Biochemistry and Molecular Biology I, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany Agenda Wednesday Scientific 17 March 2021 Program

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12.30 – 13.30 Oral Comunications 4 Oral Comunications 5

Chairs: Josiane Cillard Chairs: Carmen Gómez Laboratoire De Biologie Freshage Research Group. Cellulaire. Rennes Department of Physiology. Faculty of Medicine. University Bato Korac of Valencia and CIBERFES. Department of Physiology. Fundación Investigación Hospital Institute for Biological Research Clínico Universitario/INCLIVA. “Sinisa Stankovic”. University of Valencia. Spain Belgrade Aphrodite Vasilaki Department of Musculoskeletal OP13 – OP16 and Ageing Science. Institute of Life Course and Medical Sciences. University of Liverpool and MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA). Liverpool. United Kingdom

OP17-OP20

13.30 – 14.30 Women in Science Round Table Lin Mantell, Chang Chen, Carmen Gómez, Ting-Ting Huang, Elizabeth Ledgerwood, Maria Paola Nitti, Patricia Oteiza

14.30 – 16.00 Narrated Communications Narrated Communications

Chair: Lin Mantell Chairs: Niki Chondrogianni Department of Pharmaceutical National Hellenic Research Sciences. St. John’s University Foundation. Institute of Chemical Biology. Athens

Discussion Session 6 Consuelo Borrás NC82 – NC96 University of Valencia. Spain. Spain

Discussion Session 7 NC97 – NC115 Agenda Wednesday Scientific 17 March 2021 Program

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16.00 – 18.00 Symposium 9 Symposium 10 Redox Regulation of Neurovascular and Senescence in Ageing and Longevity Neurometabolic Coupling in Brain Aging and Disease: A Unifying View Chairs: Richard Siow King’s College London, UK Chairs: Joao Laranjinha Faculty of Pharmacy and Center Brian Kennedy for Neurosciences and Cell Departments of Biochemistry Biology, University of Coimbra, and Physiology, Beijing, National Coimbra, Portugal University of Singapore, Singapore Enrique Cadenas University of Southern California, USA Sirtuins and mTOR in aging pathways – the role of cell senescence Brian Kennedy Regulation of neurovascular coupling in Departments of Biochemistry and the brain mediated by nitric oxide: the Physiology, Beijing, National University of redox cycle of ascorbate and nitrite Singapore, Singapore Joao Laranjinha Faculty of Pharmacy and Center for Repurposing approved drugs as Neurosciences and Cell Biology, University geroprotectors: Experimental versus of Coimbra, Coimbra, Portugal epidemiological evidence Michael Ristow Calcium-dependent mechanisms of Institute of Translational Medicine, Swiss cerebral blood flow regulation Federal Institute of Technology, Zurich, Martin Lauritzen Switzerland Neuroscience, University of Copenhagen, Denmark Mitochondrial Metabolism in T Cell Activation and Aging Redox signaling in brain endothelial cells Noga Ron-Harel adapted to physiological normoxia: Faculty of Biology, Technion Israel Institute consequences for ischemia-reperfusion of Technology, Haifa, Israel injury Giovanni E. Mann Exercise and vascular ageing: endothelial King’s British Heart Foundation Centre redox regulation by Sirt1 of Excellence, Faculty of Life Sciences & Kun Ling Tsai Medicine, King’s College London, London, Department of Physical Therapy, National UK Cheng Kung University, Taiwan

Glutamate-glutamine cycling and the oxidative metabolism rate in astrocytes João Duarte Department of Experimental Medical Science, Lund University, Sweden

18.00 – 18.30 SFRR-I Annual Meeting Agenda Thursday Scientific 18 March 2021 Program

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09.00 – 11.00 Symposium 11 Oxidative stress and selective mitophagy

Chair: Quan Chen State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

Molecular regulation of mitochondrial autophagy and cellular fate Quan Chen State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

Oxidative Stress Induced Mitophagy in the Aging Heart Åsa Gustafsson Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, USA

The novel function of mitochondrial outer membrane protein Fis1 in mitochondrial dynamics and quality control Yih-Cheng Liou Department of Biological Sciences, National University of Singapore, Singapore

Autophagy of mitochondria and their association with the nucleus in mammals Michelangelo Campanella Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, UK. Consortium for Mitochondrial Research, University College London, London, UK

Break 30 min Agenda Thursday Scientific 18 March 2021 Program

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11.30 – 12.30 Keynote Lecture III

Chairs: Shinya Toyokuni Department of Pathology and Biological Responses. Nagoya University Graduate School of Medicine. Japan

Guy Jameson Faculty of Science’s School of Chemistry at the University of Melbourne

Reflections of an ageing free radical Barry Halliwell Academic Appointments and Research Excellence, Office of the Senior Deputy President and Provost, National University of Singapore, Singapore

12.30 – 13.30 Oral Comunications 6 Oral Comunications 7

Chairs: Francesco Galli Chairs: Andreas Daiber Department of Pharmaceutical Molecular Cardiology. University Sciences. Università degli Studi Medical Center Mainz di Perugia Brigitte Winklhofer-Roob Moran Benhar Institute of Molecular Biosciences. Department of Biochemistry. University of Graz Rappaport Institute for Research in the Medical Sciences. Faculty of Medicine. Technion Israel OP25 – OP28 Institute of Technology. Haifa. Israel

OP21 – OP24

Break 1 hour

14.30 – 16.00 Lester Packer Award Lecture Discovery of the KEAP1-NRF2 pathway regulating cellular response against oxidative and electrophilic stresses Masayuki Yamamoto Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Japan Agenda Thursday Scientific 18 March 2021 Program

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16.00 – 18.00 Symposium 12 Symposium 13 Cellular H2O2 gradients and Detection and quantification of the protein nanodomains in redox signaling ‘modific-ome’

Chair: Helmut Sies Chairs: Michael Davies Institute for Biochemistry and Department of Biomedical Molecular Biology I, Heinrich- Sciences, Uniersity of Heine-University Düsseldorf, Copenhagen, Denmark Düsseldorf, Germany Christian Schöneich Department of Pharmaceutical Peroxiporins in subcellular redox Chemistry, University of Kansas, homeostasis and signaling USA Roberto Sitia Division of Genetics and Cell Biology, Università Vita-Salute San Raffaele, Italy What, where and how much? Key challenges in protein oxidation Cellular hydrogen peroxide Michael Davies nanodomains Department of Biomedical Sciences, György Hajnoczky Uniersity of Copenhagen, Denmark MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Modifications of cysteine residues in the Department of Pathology, Anatomy and generation of structurally and functionally Cell Biology, Thomas Jefferson University, diverse protein species USA Dolores Perez-Sala Department of Structural and Chemical Estimating compartmental hydrogen Biology, Centro de Investigaciones peroxide steady-state concentrations Biológicas, CSIC. Spain using experiment and theory Hadley Sikes Lipid oxidation products induce specific Massachusetts Institute of Technology, protein modifications: biological effects and USA analysis by LC-MS/MS Corinne Spickett Modeling of cellular hydrogen peroxide Biosciences Research Group, landscape Aston University, UK Fernando Antunes Department of Chemistry and Oxidative protein modifications of protein Biochemistry, Faculdade de Ciências, therapeutics: targeted proteomic analysis Universidade de Lisboa, Portugal and consequences for stability, efficacy and immunogenicity Christian Schöneich Department of Pharmaceutical Chemistry, University of Kansas, USA

18.00 – 18.30 Awards and Closing ceremony Online Congress Scientific 15–18 March 2021 Program

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20th Biennial Meeting of SFRR International

SFRR-I 2021

sfrri2021.com Oral Presentations 15–16 March 2021 *OC = Oral Communications

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 12:30 12:45 1 OC 1 OP001 Adduction reactions of alphabeta- Max Sauerland Max B. Sauerland. Luke F. Department of Biomedical Sciences. University of March unsaturated carbonyls: using Gamon. Michael J. Davies Copenhagen. Denmark 2021 kinetics to determine biologically relevant reactions.

15 12:45 13:00 1 OC 1 OP002 A functional analysis to dissect Ceyhun Erdogan Yusuf Ceyhun Erdogan. Serap Faculty of Engineering and Natural Sciences. Molecular March the role of ROS signaling pathways Yusuf Sezen. Busra NurAta. Zeynep Biology. Genetics and Bioengineering Program. Sabanci 2021 using chemogenetic tools and Cokluk. Melike Secilmis. Hamza University. Istanbul. Turkey genetically encoded biosensors YusufAltun. Gulsah Sevimli. Asal for in vitro studies Ghaffari Zaki.Emrah Eroglu

15 13:00 13:15 1 OC 1 OP003 Identification of SELENBP1 as Thilo Philipp Thilo Magnus Philipp. Andreas Institute of Nutritional Sciences. Jena. Germany March a hydrogen sulfide source in Will. Karl Köhnlein. Holger 2021 intestinal epithelial cells through a Steinbrenner. Lars-Oliver Klotz novel methanethiol oxidase assay

15 13:15 13:30 1 OC 1 OP004 Identification of an Endogenous Yoshiro Saito Yoshiro Saito Tohoku University. Sendai. Japan March Long Non-coding RNA that Inhibits 2021 Selenoprotein P Translation- New regulatory mechanism of SeP translation

16 11:30 11:45 1 OC 2 OP005 Na + controls hypoxic signalling Pablo Hernansanz- Pablo Hernansanz-Agustín1. 1Centro Nacional de Investigaciones Cardiovasculares March by the mitochondrial respiratory Agustín Carmen Choya-Foces2. José (CNIC). Madrid. Spain. 2Hospital Universitario Santa 2021 chain Antonio Enríquez1. Antonio Cristina. Madrid. Spain Martínez-Ruiz2

16 11:30 11:45 2 OC 3 OP009 An inhibitor of the NRF2- Raquel Fernández- Raquel Fernández-Ginés1.2. 1Centro de Investigación Biomédica en Red sobre March βTrCP interaction suppresses Ginés Ana I. Rojo1.2. José Antonio Enfermedades Neurodegenerativas (CIBERNED). Madrid. 2021 lipopolysaccharide-mediated Encinar3.4. Geoffrey Wells5. Spain. 2Instituto de investigaciones Biomédicas “Albertos inflammation in vitro and in vivo Antonio Cuadrado1.2 Sols”. Department of Biochemistry. Faculty of Medicine. Autonomous University of Madrid (UAM). Madrid. Spain. 3Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDIBE). Alicante. Spain. 4Instituto de Biología Molecular y Celular (IBMC). Alicante. Spain. 5UCL School of Pharmacy. University College London. London. United Kingdom Oral Presentations 16 March 2021 *OC = Oral Communications

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

16 11:45 12:00 1 OC 2 OP006 Mitochondrial cristae shape Rubén Quintana- Rubén Quintana-Cabrera1.2.3. 1Institute of Functional Biology and Genomics (IBFG). March regulates ROS production under Cabrera Israel Manjarrés-Raza1.2. University of Salamanca. CSIC. Salamanca. Spain. 2Institute 2021 restrictive glycolysis Carlos Vicente-Gutiérrez1.2. of Biomedical Research of Salamanca (IBSAL). University Mauro Corrado4. Juan Pedro Hospital of Salamanca. University of Salamanca. CSIC. Salamanca. Spain. 3Department of Biochemistry and Bolaños1.2.3. Luca Scorrano5.6 Molecular Biology. University of Salamanca. Salamanca. Spain. 4Department of Immunometabolism. Max Planck Institute of Epigenetics and Immunobiology. Freiburg im Breisgau. Germany. 5Veneto Institute of Molecular Medicine. Padova. Italy. 6Department of Biology. University of Padova. Padova. Italy

16 11:45 12:00 2 OC 3 OP010 Modification of histones by Line Hallberg Line Amalie Egholm Hallberg. Department of Biomedical Sciences. University of March hypochlorous acid and its Kristine Barlous. Clare L. Copenhagen. Copenhagen. Denmark 2021 influence on vascular cell function. Hawkins

16 12:00 12:15 1 OC 2 OP007 Aberrant PFKFB3-induced Daniel Jiménez Daniel Jimenez-Blasco1.2.3. 1Institute of Functional Biology and Genomics (IBFG). March glycolysis in neurons in vivo causes Blasco Marina García-Macia1.2.3. Universidad de Salamanca. Spain. 2Institute of Biomedical 2021 mouse behavioral impairment by Carlos Vicente-Gutierrez1.2.3. Research of Salamanca (IBSAL). Hospital Universitario de mitochondrial redox stress. Ruben Quintana-Cabrera1.2.3. Salamanca. Spain. 3Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES). Emilio Fernandez1.2.3. Madrid. Spain. 4Laboratory of Angiogenesis and Vascular Peter Carmeliet4. Angeles Metabolism. Vesalius Research Center. Leuven. Belgium Almeida1.2. Juan P. Bolaños1.2.3

16 12:00 12:15 2 OC 3 OP011 Ubiquitination as a key regulatory Francesca Ferrara Francesca Ferrara1. Alessandra 1Dept. of Neuroscience and Rehabilitation.University of March mechanism for O3-induced Pecorelli2. Mascia Benedusi1. Ferrara. Ferrara. Italy. 2Plants for Human Health Institute. 2021 cutaneous redox inflammasome Erika Pambianchi2. Anna Animal Sciences Dept.. NC Research Campus. NC State activation Guiotto1. Franco Cervellati1. University. Kannapolis. NC. USA. 3Dept. of Food and Nutrition. Kyung Hee University. Seoul. Korea. Republic of Giuseppe Valacchi1.2.3

16 12:15 12:30 1 OC 2 OP008 Does the mitochondrial import Hui Lu Xiaofan Tang. Lynda K Harris. University of Manchester. Manchester. United Kingdom March and assembly (MIA) pathway Hui Lu 2021 contribute to the hydrogen peroxide production in mitochondria?

16 12:15 12:30 2 OC 3 OP012 LSD1 contributes to defining Magdalena Magdalena Strachowska. Maciej The University of Lodz. The Faculty of Biology and March pro-inflammatory phenotype of Strachowska Sobczak. Karolina Gronkowska. Environmental Protection of the University of Lodz. Lodz. 2021 human macrophages by repressing Agnieszka Robaszkiewicz Poland catalase Oral Presentations 17 March 2021 *OC = Oral Communications

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

17 12:30 12:45 1 OC 4 OP013 Adaptation of bEnd.3 brain Giovanni Mann Gabriela Warpsinski. Paul A. King’s British Heart Foundation Centre of Research March microvascular endothelial cells to Fraser. Giovanni E. Mann Excellence. King’s College London. London SE1 9NH. United 2021 physiological normoxia reduces Kingdom superoxide production associated with reperfusion injury

17 12:30 12:45 2 OC 5 OP017 Olive Oil and Exercise Training Dongwook Yeo Dongwook Yeo1.2. Tianou 1University of Minnesota Twin Cities. Minneapolis. USA. March Ameliorate Muscle Mitochondrial Zhang3. Li Li Ji1 2Mayo Clinic. Rochester. USA. 3University of Texas at San 2021 Homeostasis In Rats Fed a High-fat Antonio. San Antonio. USA Diet

17 12:45 13:00 1 OC 4 OP014 The nitrate-nitrite-nitric oxide João Gonçalves João S Gonçalves1.2. Cátia F 1Center for Neuroscience and Cell Biology of the University March pathway improves neurovascular Lourenço1.2. João Laranjinha1.2 of Coimbra. Coimbra. Portugal. 2Faculty of Pharmacy of the 2021 coupling under cerebral University of Coimbra. Coimbra. Portugal hypoperfusion conditions

17 12:45 13:00 2 OC 5 OP018 The role of Extracellular Vesicles Veronica Lisi Veronica Lisi. Chantalle University of Rome Foro Italico. Rome. Italy March in the regulation of Redox Moulton. Ambra Antonioni. 2021 Homeostasis during exercise: a Cristina Fantini. Elisa Grazioli. focus on Nrf2 and antioxidant Flavia Guidotti. Laura Capranica. enzymes Paolo Sgro. Luigi Di Luigi. Ivan Dimauro. Daniela Caporossi

17 13:00 13:15 1 OC 4 OP015 Neuron specific lack of SOD1 leads Natalie Pollock Natalie Pollock1. Kay 1Department of Musculoskeletal and Ageing Science. March to accelerated age-related loss of Hemmings1. Caroline A Institute of Life Course and Medical Sciences. University of 2021 NMJ structure Staunton1. Euan D Owen1. Liverpool and MRC-Versus Arthritis Centre for Integrated Mattia Scalabrin1. Aphrodite Research into Musculoskeletal Ageing (CIMA).Liverpool. United Kingdom. 2Molecular and Integrative Physiology. Vasilaki1. Peter C Macpherson2. University of Michigan. Ann Arbor. USA. 3Oklahoma Medical Holly Van Remmen3. Arlan Research Foundation (OMRF). Oklahoma. USA. 4University Richardson4. Susan V Brooks2. of Oklahoma Health Science Center (OUHSC). Oklahoma. Anne McArdle1. Malcolm J USA Jackson1

17 13:00 13:15 2 OC 5 OP019 Small molecule-mediated Carolin Thomas Carolin Thomas1. Reto Erni1. 1ETH Zurich. Zurich. Switzerland. 2University of Zurich. March promotion of healthspan through Jia Yee Wu1. Fabian Fischer1. Zurich. Switzerland 2021 activation of redox-sensitive Christina Boyle2. Thomas transcription factors in C. elegans A Lutz2. Erick M Carreira1. and mice Michael Ristow1 Oral Presentations 17–18 March 2021 *OC = Oral Communications

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

17 13:15 13:30 1 OC 4 OP016 Impact of SAPAP3 on Patrícia Coelho Patrícia Coelho1. Lígia Fão1.2. 1CNC - Center for Neuroscience and Cell Biology. University March mitochondrial function in Rui Nobre1.3. Luís Pereira de of Coimbra. Coimbra. Portugal. 2FMUC - Faculty of 2021 Huntington’s disease Almeida1.4. João Peça1.5. A. Medicine. University of Coimbra. Coimbra. Portugal. Cristina Rego1.2 3Institute for Interdisciplinary Research. University of Coimbra. (IIIUC). Coimbra. Portugal. 4FFUC – Faculty of Pharmacy. University of Coimbra. Coimbra. Portugal. 5FCTUC – Faculty of Science and Technology. University of Coimbra. Coimbra. Portugal

17 13:15 13:30 2 OC 5 OP020 Impact of sulforaphane on genome Aya Kurosawa Aya Kurosawa1.2.3. Seiya 1Grad. Sch. of Sci. Tech.. Gunma Univ.. Kiryu. Japan. March integrity Nishiba1. Kazuya Toriumi1. 2Gunma Univ.. Cent. Food. Sci. Wellness. Gunma Univ.. 2021 Shigeki Takeda1. Noritaka Maebashi. Japan. 3Grad. Sch. of Nanobaiosci.. Yokohama Adachi3 City Univ.. Yokohama. Japan

18 12:30 12:45 1 OC 6 OP021 Mice lacking Grx2 in mitochondria Valeria Scalcon Valeria Scalcon1. Lucia Coppo2. 1Dept. of Biomedical Sciences. University of Padova. March exhibit a metabolic phenotype Alessandra Folda1. Federica Padova. Italy. 2Dept. of Medical Biochemistry and 2021 Tonolo1. Alberto Bindoli3. Biophysics. Karolinska Institutet. Stockholm. Sweden. Nicola Ferri4. Maria Pia 3Institute of Neurosciences. CNR c/o Dept. of Biomedical Sciences. University of Padova. Padova. Italy. 4Dept. of Rigobello1 Pharmaceutical Sciences. University of Padova. Padova. Italy

18 12:30 12:45 2 OC 7 OP025 Direct antiviral agents improve Gaetano Gaetano Vidyasagar Naik Bukke*. Department of Medical and Surgical Sciences. University of March systemic redox balance in patients Francesco Bellanti. Moola Foggia. Foggia. Italy 2021 affected by chronic hepatitis C Archana. Giorgia di Bello. Francesco Cavallone. Rosanna Villani. Gaetano Serviddio

18 12:45 13:00 1 OC 6 OP022 Reductive stress complex I Yan Liang-Jun Liang-Jun Yan Department of Pharmaceutical Sciences. UNT System March hyperactivities and diabetes College of Pharmacy. University of North Texas Health 2021 Science Center. USA

18 12:45 13:00 2 OC 7 OP026 The NADPH oxidase NOX4 Irene Peñuelas- Irene Peñuelas-Haro1.2. Esther 1Bellvitge Biomedical Research Institute (IDIBELL). March regulates metabolism in Haro Bertran1.2. Eva Crosas-Molist1. Barcelona. Spain. 2CIBEREHD. Barcelona. Spain. 3Center 2021 hepatocellular carcinoma cells Fulvio Santacatterina3.4. for molecular biology Severo Ochoa (CSIC/UAM). Madrid. David Sebastian5.6.7. Sílvia Spain. 4CIBERER. Madrid. Spain. 5Biomedical Research Institute (IRB Barcelona). The Barcelona Institute of Marin2.6.8. María-Luz Science and Technology. Barcelona. Spain. 6Biochemistry Martínez-Chantar2.9. Marta and Molecular Biomedicine Department (UB). Barcelona. Cascante2.6.8. Ulla Knaus10. Spain. 7CIBERDEM. Madrid. Spain. 8Biomedicine Institute Antonio Zorzano5.6.7. Jose of Universitat de Barcelona (UB). Barcelona. Spain. 9CIC Manuel Cuezva3.4. Isabel bioGUNE. Bizkaia. Spain. 10Conway Institute (UCD). Fabregat1.2.11 Dublin. Ireland. 11Physiological Sciences Department (UB). Barcelona. Spain Oral Presentations 18 March 2021 *OC = Oral Communications

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

18 13:00 13:15 1 OC 6 OP023 Impaired lung redox metabolism Timoteo Marchini Timoteo Marchini1.2. 1Universidad de Buenos Aires. Facultad de Farmacia March and cardiac mitochondrial function Natalia Magnani1.2. Mariana y Bioquímica. Departamento de Química Analítica y 2021 aggravates myocardial infarction in Garcés1.2. Kelly Jazmín3.2. Fisicoquímica. Cátedra de Química General e Inorgánica. Buenos Aires. Argentina. 2CONICET - Universidad de Buenos a mice model of chronic exposure Mariela Paz4.5. Lourdes Aires. Instituto de Bioquímica y Medicina Molecular (IBIMOL). to urban air pollution Cáceres1.2. Romina Lasagni Buenos Aires. Argentina. 3Universidad de Buenos Aires. Vitar1.2. Valeria Calabró1.2. Facultad de Medicina. Departamento de Patología. Instituto Laura Caltana6. Mario de Fisiopatología Cardiovascular. Buenos Aires. Argentina. Contin7. Sofía Reynoso1.2. 4Universidad de Buenos Aires. Facultad de Farmacia Nestor Lago8. Tamara Vico9.2. y Bioquímica. Cátedra de Inmunología. Buenos Aires. Argentina. 5CONICET - Universidad de Buenos Aires. Instituto Virginia Vanasco9.2. Valeria de Estudios de la Inmunidad Humoral (IDEHU). Buenos Tripodi7. Silvia Alvarez9.2. Aires. Argentina. 6CONICET - Universidad de Buenos Aires. Daniel González Maglio4.5. Instituto de Biología Celular y Neurociencia (IBCN). Buenos Bruno Buchholz3.2. Alejandro Aires. Argentina. 7Universidad de Buenos Aires. Facultad Berra10. Ricardo Gelpi3.2. Pablo de Farmacia y Bioquímica. Departamento de Tecnología Evelson1.2 Farmacéutica. Buenos Aires. Argentina. 8Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Patología Experimental y Aplicada. Buenos Aires. Argentina. 9Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Fisicoquímica. Buenos Aires. Argentina. 10Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Inmunopatologías. Buenos Aires. Argentina

18 13:00 13:15 2 OC 7 OP027 Hexameric procyanidins inhibit Wei Zhu Wei Zhu1. Elena Daveri1.2. Ana 1University of California. Davis. USA. 2Fondazione IRCCS March colorectal cancer cell growth M. Adamo3. Eugenia Alfine1. Istituto Nazionale dei Tumori. Davis. USA. 3Universidad de 2021 through redox regulation of the Patricia I. Oteiza1 Buenos Aires. Buenos Aires. Argentina epidermal growth factor signaling pathway

18 13:15 13:30 1 OC 6 OP024 NETs formation in blood of Agnieszka Piotr Wójcik1. Marzena 1Medical University of Bialystok. Bialystok. Poland. March psoriatic patients modified by Gęgotek Garley1. Adam Wroński2. 2Dermatological Specialized Center “DERMAL” NZOZ in 2021 cannabidiol Ewa Jabłońska1. Elżbieta Bialystok. Bialystok. Poland Skrzydlewska1

18 13:15 13:30 2 OC 7 OP028 Investigating the stress sensitivity Rauter Thomas Thomas Rauter1. Benjamin 1Chair of Molecular Biology and Biochemistry. Gottfried March of the secretory pathway in Gottschalk1. Sandra Schatz Research Centre. Medical University of Graz. Graz. 2021 cancer cells using high-resolution Burgstaller1.2. Jeta Ramadani- Austria2Interfaculty Institute of Cell Biology. University of Tuebingen. Tuebingen. Germany3Department of fluorescence imaging Muja1. Helmut Bischof1.2. Jesse Pharmacology. Toxicology and Clinical Pharmacy. Institute C. Hay3. Wolfgang F. Graier1.4. of Pharmacy. University of Tuebingen. Tuebingen. Roland Malli1.4 Germany4Division of Biological Sciences and Center for Structural and Functional Neuroscience. The University of Montana. Missoula. MT. USA5BioTechMed Graz.Graz. Austria Narrated Communications 15 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 12:30 13:30 2 DS 1 NC001 The cellular vimentin network Patricia González Patricia González-Jiménez. Sofía Department of Structural and Chemical Biology. Centro de March undergoes distinct reorganizations Jiménez Duarte. Alma E. Fernández. Investigaciones Biológicas Margarita Salas. Consejo Superior 2021 in response to diverse Elena Navarro-Carrasco. Silvia de Investigaciones Científicas (CSIC). Madrid. Spain electrophiles or mutations of its González-Sanz. Álvaro Viedma- single cysteine residue Poyatos. María A. Pajares. Dolores Pérez-Sala

15 12:30 13:30 2 DS 1 NC002 oxSWATH applied to the study of Sandra Anjo Margarida Neves1.2. Mário 1Center for Neuroscience and Cell Biology. University of March the alteration of intracellular and Grãos1.3.4. Bruno Manadas1.3. Coimbra. Coimbra. Coimbra. Portugal. 2Department of 2021 extracellular proteome of cells in Sandra Anjo1.3 Chemistry. University of Aveiro. Aveiro. Portugal. 3Institute response to oxidative stress for Interdisciplinary Research. University of Coimbra (IIIUC). Coimbra. Portugal. 4Biocant. Technology Transfer Association. Cantanhede. Portugal. Coimbra. Portugal

15 12:30 13:30 2 DS 1 NC003 H2O2 biosensors HyPer2 HyPer3 Jesús Palomero Escarlata Fernández- 1Department of Physiology and Pharmacology. University of March and GFP2-Orp1 detect rapid pH Labajos Puente1.2.3. Eva Martín- Salamanca. Salamanca. Spain. 2Institute of Neurosciences 2021 changes due to environmental Prieto1. Jesús Palomero1.2.3 of Castilla y León (INCYL). Salamanca. Spain. 3Institute of CO2 fluctuations in addition to Biomedical Research of Salamanca (IBSAL). Salamanca. intracellular H2O2 in isolated Spain skeletal muscle fibres

15 12:30 13:30 2 DS 1 NC004 PRDX2- and PRDX3-rsGFP2 fusions: Martin Hugo Martín Hugo1. Carmen Choya- 1Instituto de Investigación Sanitaria Princesa. Madrid. March response to relevant oxidants and Foces1. Daniel Pastor-Flores2. Spain. 2KBI Biopharma. Louvain. Flemish Region. Belgium. 2021 redox sensors during hypoxia and Antonio Martínez-Ruiz1.3.4 3Departamento de Bioquímica y Biología Molecular. reoxygenation inside living cells. Universidad Complutense de Madrid (UCM). Madrid. Spain. 4Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV). Madrid. Spain

15 12:30 13:30 2 DS 1 NC005 Performance evaluation tests of Mika Tada Mika Tada. Daichi Okuyama. Tohoku Institute of Technology. Sendai. Japan March an auto-fluorescence observation Naoki Sato 2021 system for non-invasive biological measurements

15 12:30 13:30 2 DS 1 NC006 Redox control of the Fran Artime Francisco Artime-Naveda. Rafael University of Oviedo. School of Medicine. IUOPA. Oviedo. March transcriptional circadian Cernuda-Cernuda. Alejandro Spain 2021 rhythmicity by SOD2 Álvarez-Artime. Alba Morán- Álvarez. Juan C Mayo. Rosa M Sainz

15 12:30 13:30 2 DS 1 NC007 Lipid peroxidation as measured by Mar Dromant Mar Dromant. Cristina Mas- University of Valencia. Valencia. Spain March chromatographic determination of Jarque Bargues. Consuelo Escrivá. 2021 malondialdehyde. Human plasma Consuelo Borrás. José Viña reference values in health and disease. Narrated Communications 15 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 12:30 13:30 2 DS 1 NC008 Diffusion and Removal Kinetics of Ana Ledo Ana Ledo1.2. Eliana 1University of Coimbra. Faculty of Pharmacy. Coimbra. March Hydrogen Peroxide in Brain Tissue Fernandes1.2. João Portugal. 2Center for Neuroscience and Cell Biology. 2021 Laranjinh1.2. Rui M. Barbosa1.2 Coimbra. Portugal

15 12:30 13:30 2 DS 1 NC009 How far can hydrogen peroxide Tânia Sousa Tânia Sousa1. Rui Travasso2. 1Faculty of Science and Technology. University of Coimbra. March travel in blood circulation? Armindo Salvador3.4.5 Coimbra. Portugal. 2CFisUC. Department of Physics. 2021 University of Coimbra. Coimbra. Portugal. 3CNC - Centre for Neuroscience Cell Biology. University of Coimbra. Coimbra. Portugal. 4CQC. Department of Chemistry. University of Coimbra. Coimbra. Portugal. 5Institute for Interdisciplinary Research. University of Coimbra. Coimbra. Portugal

15 12:30 13:30 2 DS 1 NC010 Effect of longitudinal magnetic Ken-Ichiro Ken-ichiro Matsumoto. Ikuo National Institute of Radiological Sciences. Quantum March field to the linear particle-beam Matsumoto Nakanishi. Yasushi Abe. Shinji Medical Science Directorate. National Institutes for 2021 track on yields of hydroxyl radical Sato. Masayuki Muramatsu. Quantum and Radiological Science and Technology. Chiba. and hydrogen peroxide in water Ryosuke Kohno. Dousatsu Japan Sakata. Kota Mizushima. Hideyuki Mizumo. Taku Inaniwa

15 12:30 13:30 2 DS 1 NC011 High concentrations of caseins in Eduardo Fuentes Eduardo Fuentes-Lemus. University of Copenhagen. Copenhagen. Denmark March milk propitiate the occurrence of Lemus Shuwen Jiang. Per Hägglund. 2021 chain reactions and propagation of Michael J. Davies oxidative damage

15 14:30 16:00 1 DS 2 NC012 Modulation of mitochondrial Sara López Sara López-Bellón1. Sandra 1University of Cordoba. Córdoba. Spain. 2Translational March metabolism markers and Rodríguez-López1. Luz Marina Gerontology Branch. National Institute on Aging. National 2021 mitochondrial morphology by Sánchez-Mendoza1. Elena Institutes of Health. Baltimore. USA aging and CYB5R3 overexpression Sabariego1. Rafael de Cabo2. M. in transgenic mice Isabel Burón1. José A. González- Reyes1. José M. Villalba1

15 14:30 16:00 1 DS 2 NC013 Regulation of coenzyme Sandra Rodríguez Sandra Rodríguez-López1. 1Departamento de Biología Celular. Fisiología e March Q biosynthesis by n-3 López Lucía Fernández-del-Río1.2. Inmunología. Universidad de Córdoba. Campus de 2021 polyunsaturated fatty acids Elena Gutiérrez-Casado1. José Excelencia Internacional Agroalimentario ceiA3. Córdoba. Antonio González-Reyes1. Spain. 2Department of Chemistry & Biochemistry. and the Molecular Biology Institute. University of California. Los María Isabel Burón1. Catherine Angeles. USA F. Clarke2. José Manuel Villalba1

15 14:30 16:00 1 DS 2 NC014 Low abundance of NDUFV2 Mariona Jove Natalia Mota-Martorell. José Department of Experimental Medicine. Lleida Biomedical March subunit of the hydrophilic complex Daniel Galo-Licona. Meritxell Research Institute (IRBLleida). Lleida University (UdL). 2021 I domain predicts animal longevity Martín-Gari. Joaquim Sol. Lleida. Spain Reinald Pamplona. Mariona Jové Narrated Communications 15 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 14:30 16:00 1 DS 2 NC015 Succination of protein thiols in Reinald Pamplona Mariona Jové. Natàlia Mota- University of Lleida. Lleida. Spain March human frontal cortex during aging Martorell. José Daniel Galo- 2021 Licona. Meritxell Martín-Gari. Joaquím Sol. Marc Bernaus. Reinald Pamplona

15 14:30 16:00 1 DS 2 NC016 Extracellular Vesicle Production Kay Hemmings Kay Hemmings1. Natalie 1University of Liverpool. Liverpool. United Kingdom. March by Skeletal Muscle: Role in Pollock1. Euan Owen1. Caroline 2University of Michigan. Michigan. USA 2021 Neuromuscular Ageing Staunton1. Susan V. Brooks2. Anne McArdle1

15 14:30 16:00 1 DS 2 NC017 Development of age-related loss Kat Kumiscia Kat Kumiscia1.2. Shahjahan 1Department of Musculoskeletal Biology. Institute of Life March of muscle mass and function – role Shigdar1.2. Carole Proctor3.4. course and Medical Sciences. University of Liverpool. 2021 of oxidative DNA damage repair Daryl Shanley3.4. Euan Liverpool. United Kingdom. 2MRC-Arthritis Research UK systems Owen1.2. Caroline Staunton1.2. Centre for Integrated Research into Musculoskeletal Ageing (CIMA). Liverpool. United Kingdom. 3Institute for Ageing. Malcolm Jackson1.2. Lesley Campus for Ageing and Vitality. Newcastle University. Iwanejko1.2. Anne McArdle1.2 Newcastle. United Kingdom. 4MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA). Newcastle. United Kingdom

15 14:30 16:00 1 DS 2 NC018 Redox proteomics reveal Jamie Pugh Jamie Pugh1. Clare Stretton2. 1Liverpool John Moores University. Liverpool. United March differential effects of both ageing Brian McDonagh3. Philip Kingdom. 2University of Liverpool. Liverpool. United 2021 and exercise on human skeletal Brownridge2. Anne McArdle2. Kingdom. 3National University of Ireland Galway. Galway. muscle Malcolm Jackson2. Graeme Ireland Close1

15 14:30 16:00 1 DS 2 NC019 Endurance exercise and Daniela Caporossi Ivan Dimauro. Elisa Grazioli. University of Rome Foro Italico. Rome. Italy March immune function: role of redox Veronica Lisi. Flavia Guidotti. 2021 homeostasis and inflammatory Cristina Fantini. Cristina biomarkers in systemic adaptation Antinozzi. Paolo Sgrò. Luigi Di Luigi. Laura Capranica. Daniela Caporossi

15 14:30 16:00 1 DS 2 NC020 Personalized multicomponent Fernando Millán Fernando Millan1. Aitor 1Freshage Research Group. Department of Physiology. March physical exercise program for the Carretero1. Esther García- Faculty of Medicine. University of Valencia and CIBERFES. 2021 prevention and reversal of frailty in Domínguez1. Ángela García- Fundación Investigación Hospital Clínico Universitario/ the elderly Correas1. Cristina García- INCLIVA.. Valencia. Spain. 2INRA. UMR866 Dynamique Musculaire et Métabolisme. Université de Montpellier. Domínguez1. Adrián De la Montpellier. France Rosa1. Coralie Arc-Chagnaud2. Gloria Olaso-González1. Mª Carmen Gómez-Cabrer1. Jose Viña1 Narrated Communications 15 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 14:30 16:00 1 DS 2 NC021 Multicomponent high intensity Esther García- Esther García-Domínguez1. 1Freshage Research Group. Department of Physiology. March interval training induces positive Domínguez Coralie Arc-Chagnaud1.2. Faculty of Medicine. University of Valencia and CIBERFES. 2021 adaptations in old glucose- Adrián De la Rosa1. Ángela Fundación Investigación Hospital Clínico Universitario/ 6-phosphate dehydrogenase G Correas1. Cristina García- INCLIVA. Valencia. Spain. 2INRA. UMR866 Dynamique Musculaire et Métabolisme. Université de Montpellier. overexpressing mice Domínguez1. Aitor Carretero1. Montpellier. France Fernando Millán1. Gloria Olaso-González1. Mari Carmen Gómez-Cabrera1. José Viña1

15 14:30 16:00 1 DS 2 NC022 The NAD+ precursor nicotinamide Ángela García Ángela G. Correas. Coralie Freshage Research Group. Physiology Department March riboside improves redox Correas Arc-Chagnaud. Adrián De la (University of Valencia). Valencia. Spain 2021 homeostasis and performance in Rosa. Aitor Carretero. Esther old mice García-Domínguez. Fernando Millán. Gloria Olaso-González. Mari Carmen Gómez-Cabrera. José Viña

15 14:30 16:00 1 DS 2 NC023 Apigenin and Rutaecarpine target Dalia Ali Dalia Ali1. Sara Abuelreich2. 1OUH.SDU.KMEB. Odense. Denmark. 2KSU. SCU. Riyadh. March cellular senescence to prevent Radhakrishnan Vishnubalaji3. Saudi Arabia. 3HBKU.QBRI. Doha. Qatar 2021 aging-bone phenotype in human Nicholas Ditzel1. Meshail mesenchymal skeletal stem cells. Okla2. Paula Fernandez- Guerra1. Justyna M Kowal1. Rimi Hamam2. Musaad Alfayez2. Abdullah Aldahmash2. Moustapha Kassem1. Nehad AlAjez3

15 14:30 16:00 1 DS 2 NC024 Physical contact between Judith Félix Judith Félix1.2. Estefanía Díaz- 1Department of Genetics. Physiology and Microbiology March prematurely aging and non- Del Cerro1.2. Mónica De la (Animal Physiology unit). Faculty of Biology. Complutense 2021 prematurely aging mice while they Fuente1.2 University. Madrid. Spain. 2Institute of Investigation cohabit is crucial to improve their Hospital 12 Octubre. Madrid. Spain oxidative state

15 14:30 16:00 1 DS 2 NC025 Akkermansia muciniphila: a new Estefanía Díaz Del Estefanía Díaz-Del Cerro1.2. 1Department of Genetics. Physiology and Microbiology March ally to combat the oxidative stress Cerro Manuel Lambea Hernansanz1. (Unity of Animal Physiology). Faculty of Biology. Complutense 2021 of aging Nuria Salazar3. Miguel University of Madrid (UCM).. Madrid. Spain. 2Institute of Investigation Hospital 12 de Octubre (i+12).. Madrid. Spain. Gueimonde3. Mónica De la 3Department of Microbiology and Biochemistry of Dairy Fuente1.2 Products. IPLA-CSIC. Diet. Microbiota and Health Group. ISPA.. Asturias. Spain Narrated Communications 15 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 14:30 16:00 1 DS 2 NC026 Intermittent Cold and Hypobaric Teresa Carbonell Raquel G. Bardallo*. Garoa University of Barcelona. Barcelona. Spain March Hypoxia Treatment Modulates Santocildes*. Joan Ramon 2021 Oxidative Stress in Injured Muscles Torrella. Teresa Carbonell. Ginés of Rats Viscor

15 14:30 16:00 1 DS 2 NC027 Small extracellular vesicles from Cristina Mas Cristina Mas-Bargues. Jorge Universitat de València. Valencia. Spain March healthy cells improves cell function Bargues Sanz-Ros. Aurora Román- 2021 and stemness in premature Domínguez. Lucia Gimeno- senescent stem cells by miR-302b Mallench. Jose Viña. Consuelo and HIF-1a activation Borrás

15 14:30 16:00 1 DS 2 NC028 Age- and sex-dependent changes Kristina Lossow Kristina Lossow1.2.3.4. Maria 1Friedrich Schiller University Jena. Institute of Nutritional March of trace elements and redox Schwarz1.3. Johannes Kopp2.3. Sciences. Department of Molecular Nutritional Physiology. Jena. Germany. 2University of Potsdam. Institute of 2021 parameters in mice Tanja Schwerdtle2.3. Anna Nutritional Science. Department of Food Chemistry. Nuthetal. Kipp1.3 Germany. 3TraceAge - DFG Research Unit on Interactions of essential trace elements in healthy and diseased elderly. Potsdam-Berlin-Jena-Wuppertal. Germany. 4German Institute of Human Nutritio. Nuthetal. Germany

15 14:30 16:00 1 DS 2 NC029 Copper-mediated changes in Maria Schwarz Maria Schwarz1.2. Kristina 1Institute of Nutritional Sciences. Department of Molecular March cellular selenium metabolism Lossow1.2. Julian Hackler3.2. Nutritional Physiology. Friedrich Schiller University of Jena. Jena. Germany. 2TraceAge-DFG Research Unit #2558 on 2021 Johannes Kopp4.2. Lutz Interactions of essential trace elements in healthy and Schomburg3.2. Tanja diseased elderly. Potsdam-Berlin-Jena-Wuppertal. Germany. Schwerdtle4.2. Anna Kipp1.2 3Institute for Experimental Endocrinology. Charité–Medical University. Berlin. Germany. 4Institute of Nutritional Science. Department of Food Chemistry. University of Potsdam. Nuthetal. Germany

15 14:30 16:00 2 DS 3 NC030 Distinctive under-expression Elena Milanesi Elena Milanesi1. Gina 1“Victor Babes” National Institute of Pathology. Bucharest. March profile of inflammatory and redox Manda1. Maria Dobre1. Romania. 2“Carol Davila” University of Medicine and Pharmacy. Bucharest. Romania. 3Neurology Department. 2021 genes in the blood of elderly Elena Codrici1. Ionela Victoria Clinical Hospital Colentina. Bucharest. Romania. 4“Ana patients with cardiovascular Neagoe1. Bogdan Ovidiu Aslan” International Foundation. Excellence Center for disease. Popescu1.2.3. Luiza Spiru2.4. Memory Diseases and Longevity Medicine. Bucharest. Catalina Tudose2.5. Gabriel Romania. 5"Prof. Dr. Al. Obregia" Psychiatry Clinical Hospital Ioan Prada2.6. Eugenia & The Memory Center of the Romanian Alzheimer Society. Bucharest. Romania. 6“Ana Aslan” National Institute of Irene Davidescu2.3. Gerard Gerontology and Geriatrics. Bucharest. Romania. 7Unitat Pinol-Ripoll7. Antonio Trastons Cognitius. Hospital Universitari Santa Maria- Cuadrado1.8.9.10.11 IRBLLeida. Lleida. Spain. 8Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC. Madrid. Spain. 9Department of Biochemistry. Faculty of Medicine. Autonomous University of Madrid. Madrid. Spain. 10Instituto de Investigación Sanitaria La Paz. Madrid. Spain. 11Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNERD). ISCIII. Madrid. Spain Narrated Communications 15 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 14:30 16:00 2 DS 3 NC031 Sulforaphane supplementation Paraskevi-Maria Paraskevi-Maria Psefteli1. 1King’s British Heart Foundation Centre of Research March of murine insulin-resistant Psefteli Jessica Morris1. Paul Taylor2. Excellence. School of Cardiovascular Medicine and Sciences. 2021 pregnancy normalises adaptive Giovanni Mann1. Sarah Faculty of Life Sciences & Medicine. King`s College London. London. United Kingdom. 2Department of Women & Nrf2 responses in offspring lung Chapple1 Children’s Health. Faculty of Life Sciences & Medicine. King`s endothelial cells and protects College London. London. United Kingdom mother and offspring from cardiometabolic syndrome.

15 14:30 16:00 2 DS 3 NC032 Metallomic profiling in human Giovanni Mann Matthew J. Smith1. Alexander P. 1King's British Heart Foundation Centre of Research March coronary artery endothelial cells: Morrell2. Theodora J. Stewart3. Excellence. King's College London. London SE1 9NH. United 2021 effects of physiological oxygen Wolfgang Maret3. Ron Jacob1. Kingdom. 2Oral. Dental and Craniofacial Research. Dental Institute. King's College London. London. United Kingdom. levels and ischemia-reoxygenation Giovanni E. Mann1 3The London Metallomic Facility. King's College London. injury London SE1 9NH. United Kingdom

15 14:30 16:00 2 DS 3 NC033 Citrullination of histones decreases Rebeca Osca- Rebeca Osca-Verdegal1.2. Jesús 1Instituto de Investigación Sanitaria INCLIVA. Valencia. March extracellular histones-mediated Verdegal Beltrán-García3.1.2. Ana B. Spain. 2Departamento de Fisiología. Facultad de Medicina 2021 oxidative stress cell death and Paes1.2. Elena Nacher-Sendra2. y Odontología. Universitat de València. Valencia. Spain. 3Centro de Investigación Biomédica en Red de Enfermedades vascular dysfunction in endothelial Federico V. Pallardó1.2.3. José Raras (CIBERER). Madrid. Spain cells. Luis García-Giménez1.2.3

15 14:30 16:00 2 DS 3 NC034 Extracellular histones induce Rebeca Osca- Jesús Beltrán-García1.2.3. 1Departamento de Fisiología. Facultad de Medicina y March oxidative stress and endothelial Verdegal Rebeca Osca-Verdegal1.3. Elena Odontología. Universitat de València. Valencia. Spain. 2021 pyroptosis leading to severe Nacher-Sendra1. Federico V. 2Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER). Madrid. Spain. 3Instituto de Investigación phenotypes in sepsis. Pallardó1.4.5. José Luis García- Sanitaria INCLIVA. Valencia. Spain. 4Centro de Investigación Giménez1.4.5 Biomédica en Red de Enfermedades Raras (CIBERER). Valencia. Spain. 5Instituto de Investigación Sanitaria INCLIVA. Madrid. Spain

15 14:30 16:00 2 DS 3 NC035 Obesity causes PGC-1α deficiency Salvador Pérez Sergio Rius-Pérez1. Salvador 1Department of Physiology. University of Valencia. Valencia. March in exocrine pancreas leading to Pérez1. Pablo Martí-Andrés1. Spain. 2Institute of Biomedical Research "Alberto Sols".CSIC- 2021 IL-6 upregulation via NF-κB in Isabela Finamor1. Ignacio UAM. Madrid. Spain acute pancreatitis Prieto2. Raquel García2. María Monsalve2. Juan Sastre1

15 14:30 16:00 2 DS 3 NC036 Nitration of cystathionine Salvador Pérez Sergio Rius-Pérez1. Salvador 1Department of Physiology. University of Valencia. Valencia. March β-synthase in acute pancreatitis Pérez1. Isabel Torres-Cuevas2. Spain. 2Neonatal Research Group. Health Research Institute 2021 Pablo Martí-Andrés1. Raquel La Fe. Valencia. Spain. 3Department of Pharmacy and Pharmaceutical Technology and Parasitology. University of Taléns-Visconti3. Alberto Valencia. Valencia. Spain. 4Proteomics Unit. National Center Paradela4. Laura Guerrero4. for Biotechnology. CSIC. Madrid. Spain. 5Department of Luis Franco5.6. Gerardo Biochemistry and Molecular Biology. University of Valencia. López-Rodas5.6. Luis Torres5.6. Valencia. Spain. 6Institute of Health Research. INCLIVA. Fernando Corrales4. Juan Sastre1 Valencia. Spain Narrated Communications 15 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 14:30 16:00 2 DS 3 NC037 NAD+ boosters reduce the Carlos Pérez- Carlos Pérez-Sánchez1.2. Luz 1Department of Cell Biology. Physiology and Immunology. March oxidative apoptotic and Sánchez Marina Sánchez-Mendoza1. University of Cordoba. Campus de Excelencia Internacional 2021 inflammatory status of leukocytes María del Carmen Abalos- Agroalimentario. ceiA3. Córdoba. Spain. 2Rheumatology service. IMIBIC/Reina Sofia Hospital/University of Cordoba. from rheumatoid arthritis patients Aguilera2. Alejandro Escudero Córdoba. Spain Contreras2. Juan Antonio Moreno1. Nuria Barbarroja2. Eduardo Collantes-Estévez1. Sara López-Bellón1. Sandra Rodríguez-López1. María Isabel Burón1. José Antonio González- Reyes1. Chary López-Pedrera2. José Manuel Villalba1

15 14:30 16:00 2 DS 3 NC038 Phenotypic changes to vascular Sara Marthedal Sara M. Jørgensen. Christine Y. Dept. Biomedical Sciences. Panum Institute. University of March smooth muscle cells induced by Jørgensen Chuang. Michael J. Davies Copenhagen. Copenhagen. Denmark 2021 oxidant-modified extracellular matrix.

15 14:30 16:00 2 DS 3 NC039 Adduction reactions of Max Sauerland Max B. Sauerland. Luke F. University of Copenhagen. Copenhagen. Denmark March dimethylfumarate: a 60-year- Gamon. Michael J. Davies 2021 old drug with potent but poorly understood mechanisms of action.

15 14:30 16:00 2 DS 3 NC040 Vascular barrier protective Víctor Gutiérrez Víctor Gutiérrez González. Universidad de Burgos. Burgos. Spain March effects of antioxidant white-wine Gisela Gerardi. Mónica Cavia 2021 pomace products against Listeria Saiz. Ana M Diez Maté. Beatriz monocytogenes in endothelial Melero. M Dolores Rivero. M cells Luisa González SanJose. Isabel Jaime. Pilar Muñiz

15 14:30 16:00 2 DS 3 NC041 Acute dietary nitrate Antoni Pons Xavier Capó1.2. Antoni 13Health Research Institute of the Balearic Islands (IdISBa). March supplementation modulates the Pons3.4.5. Clara Reynes2. 07120 Palma. Spain.. Palma de Mallorca. Spain. 21Research 2021 inflammatory response induced by Miguel-David Ferrer2.4.5 Group in Community Nutrition and Oxidative Stress. University of the Balearic Islands. 07122 Palma. Spain;. endotoxin and phorbol-miristate Palma. Spain. 31Research Group in Community Nutrition and Oxidative Stress. University of the Balearic Islands. 07122 Palma. Spain;. Palma de Mallorca. Spain. 42 CIBEROBN (Fisiopatología de la Obesidad y la Nutrición CB12/03/30038). Instituto de Salud Carlos III. 28029 Madrid. Spain.. Madrid. Spain. 53Health Research Institute of the Balearic Islands (IdISBa). 07120 Palma. Spain.. Palma. Spain Narrated Communications 15–16 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

15 14:30 16:00 2 DS 3 NC042 An increase in mitochondrial DNA Mizuho Okamoto Mizuho Okamoto. Akari Tokyo univercity of technology. Tokyo. Japan March copy number was observed in Nakamura. Yusuke Suga. Akio 2021 monocyte cell line differentiated Fujisawa. Yorihiro Yamamoto. into macrophages but not in Misato Kashiba mitochondrial respiratory protein mRNA levels and TFAM.

15 14:30 16:00 2 DS 3 NC043 Quercetin protects SH-SY5Y cells Veronica Zingales Veronica Zingales. Mónica University of Valencia. Faculty of Pharmacy. Valencia. Spain March against sterigmatocystin-induced Fernández-Franzón. María-José 2021 toxicity: prevention of NF-κB Ruiz nuclear translocation and down regulation of HO-1 expression

15 14:30 16:00 2 DS 3 NC044 Antimicrobial and anti- Michal Korinek Michal Korinek1.2.3. 1Chang Gung University. Taoyuan. Taiwan. 2National Cheng March inflammatory effects of volatile Heba Handoussa4. Olha Kung University. Tainan. Taiwan. 3Kaohsiung Medical 2021 oils widely used in Mediterranean Mykhailenko5. Meng-Hua University. Kaohsiung. Taiwan. 4German University in Cairo. Cairo. Egypt. 5National University of Pharmacy. Kharkiv. diet. Chen1. Zan-Wei Chiou1. You- Ukraine. 6National Sun Yat-sen University. Kaohsiung. Taiwan Ying Chen6. Yi-Hong Tsai3. Bing-Hung Chen3. Mohamed El-Shazly4. Tsong-Long Hwang1

16 13:30 15:00 1 DS 4 NC045 Metabolic remodeling results in Sónia Pinho Sónia A. Pinho1.2. Cláudio 1CNC. Center for Neuroscience and Cell Biology. University March alterations in the redox responses Costa1. Inês Miranda-Santos1. of Coimbra. Coimbra. Portugal. 2PDBEB - PhD Programme 2021 of human dermal fibroblasts Sonia L. Pinho1. Paulo J. in Experimental Biology and Biomedicine. Center for Neuroscience and Cell Biology. University of Coimbra. Oliveira1. Teresa Cunha- Coimbra. Portugal Oliveira1

16 13:30 15:00 1 DS 4 NC046 Microgravity induces cellular Mascia Benedusi Mascia Benedusi1. Rita 1Department of Neurosciences and Rehabilitation. University March senescence in human Canella1. Anna Guiotto1. Franco of Ferrara. Ferrara. Italy. 2Plants for Human Health Institute 2021 keratinocytes Cervellati1. Francesca Ferrara1. Animal Science Dept. NC Research Campus. Kannapolis. NC. USA. 3Dept. of Food and Nutrition Kyung Hee University.. Giuseppe Valacchi1.2.3 Seoul. Korea. Republic of

16 13:30 15:00 1 DS 4 NC047 Antimicrobial peptides as possible Erika Pambianchi Erika Pambianchi1. Brittany 1Plants for Human Health Institute Animal Science Dept. March new players in pollution-mediated Woodby1. Francesca Ferrara1.2. Kannapolis. USA. 2University of Ferrara. Department of 2021 skin damage Jean-Philippe Therrien3. Life Sciences and Biotechnology. Ferrara. Italy. 3JP Therrien Consulting. LLC. Kannapolis. USA. 4Kyung Hee University. Alessandra Pecorelli1. Nicolò Department of Food and Nutrition. Seul. Korea. Republic of Messano1. Mary Ann Lila1. Giuseppe Valacchi1.2.4 Narrated Communications 16 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

16 13:30 15:00 1 DS 4 NC049 NALP1 involvement in Cigarette Roxane Prieux Roxane Prieux1.2. Mascia 1University of Ferrara. Ferrara. Italy. 2Dow Silicones March Smoke induces cutaneous Benedusi1. Francesca Belgium. Seneffe. Belgium. 3North Carolina State University. 2021 inflammation Ferrara1. Anna Guiotto1. Kannapolis. USA. 4Kyung Hee University. Seoul. Korea. Franco Cervellati1. Giuseppe Republic of Valacchi1.3.4

16 13:30 15:00 1 DS 4 NC050 Ascorbic acid and rutin Agnieszka Agnieszka Gęgotek1. Pedro 1Medical University of Bialystok. Bialystok. Poland. March cooperation in protecting of Gęgotek Domingues2. Elżbieta 2University of Aveiro. Aveiro. Portugal 2021 the proteome of UV irradiated Skrzydlewska1 fibroblasts cultured in a three- dimensional system

16 13:30 15:00 1 DS 4 NC051 Cannabidiol effect on the Agnieszka Sinemyiz Atalay1. Agnieszka 1Medical University of Bialystok. Bialystok. Poland. March proteomic profile of keratinocytes Gęgotek Gęgotek1. Pedro Domingues2. 2University of Aveiro. Aveiro. Portugal 2021 isolated from rats skin exposed to Elżbieta Skrzydlewska1 UVA and UVB radiation

16 13:30 15:00 1 DS 4 NC052 Effect of cannabidiol on Agnieszka Anna Jastrząb1. Michał 1Medical University of Bialystok. Bialystok. Poland. March phospholipid metabolism in Gęgotek Biernacki1. Iwona Jarocka- 2Dermatological Specialized Center “DERMAL” NZOZ in 2021 keratinocytes from patients with Karpowicz1. Adam Wroński2. Bialystok. Bialystok. Poland. 3LabOS. Rudjer Boskovic Institute. Laboratory for Oxidative Stress. Zagreb. Croatia psoriasis Neven Zarkovic3. Elżbieta Skrzydlewska1

16 13:30 15:00 1 DS 4 NC053 Active compounds combination Jiangang Shen Jie Chen*. Lu Zhang. Meiling The University of Hong Kong. Hong Kong March ameliorates CFA-induced Wu. Jiangang Shen 2021 inflammatory model by attenuating macrophage-mediated localized response and nitrative damage

16 13:30 15:00 1 DS 4 NC054 Anti-inflammatory and anti- Soraya L. Valles Adrian Jorda. Constanza Department of Physiology. School of Medicine. University of March oxidant effects of ranolazine in Aldasoro. María Dolores Valencia.. Valencia. Spain 2021 astrocytes in primary culture. Mauricio. Patricia Marchio. Andrea Suarez. Sol Guerra- Ojeda. Martin Aldasoro. Jose María Vila. Soraya L. Valles

16 13:30 15:00 1 DS 4 NC055 Effects of aspirin on inflammation Soraya L. Valles Constanza Aldasoro. Adrian Department of Physiology. School of Medicine. University of March and oxidative stress induced Jorda. María Dolores Mauricio. Valencia. Valencia. Spain 2021 by Aβ1-42 in astrocytes in primary Patricia Marchio. Begoña culture. Belmonte. Sol Guerra-Ojeda. Martin Aldasoro. Jose María Vila. Soraya L. Valles Narrated Communications 16 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

16 13:30 15:00 1 DS 4 NC056 White-wine pomace product Mónica Cavia Mónica Cavia-Saiz. Gisela Department of Biotechnology and Food Science. Faculty of March modulates oxidative stress and Gerardi. Mª Dolores Rivero- Sciences. University of Burgos. Burgos. Spain 2021 inflammation in endothelial Pérez. Mª Luisa González dysfunction through NF-κB SanJose. Pilar Muñiz

16 13:30 15:00 1 DS 4 NC057 Modulation of mitochondrial Luz Marina Luz Marina Sánchez-Mendoza1. 1Department of Cell Biology. Physiology and Immunology. March autophagic and nutrient sensing Sánchez Mendoza Sandra Rodríguez-López1. María Faculty of Sciences. University of Córdoba. Agrifood 2021 pathways markers in liver and Isabel Burón1. José Antonio Campus of International Excellence (ceiA3). Córdoba. Spain. 2Translational Gerontology Branch. National Institute on skeletal muscle by overexpression González-Reyes1. Rafael de Aging. National Institutes of Health. Baltimore. USA of the redox enzyme NADH- Cabo2. José Manuel Villalba1 cytochrome b5 reductase-3 in male and female mice

16 13:30 15:00 1 DS 4 NC058 New antioxidant soy-derived Federica Tonolo Federica Tonolo1. Laura 1Department of Biomedical Sciences. University of March bioactive peptides released Moretto1. Alessandro Padova. Padova. Italy. 2Proteomics Center. University of 2021 through simulated gastrointestinal Grinzato1. Federico Fiorese1. Padova and Azienda Ospedaliera di Padova. Padova. Italy. 3CRIBI. Biotechnology Center. Padova. Italy. 4Institute of digestion modulate Keap1/Nrf2 Alessandra Folda1. Valeria Neuroscience (CNR).. Padova. Italy pathway response Scalcon1. Stefania Ferro1. Giorgio Arrigoni1.2.3. Alberto Bindoli4. Oriano Marin1. Maria Pia Rigobello1

16 13:30 15:00 1 DS 4 NC059 Reactive Oxygen Species as Jonathan Scavuzzo Jonathan Scavuzzo1.2. 1Charles Perkin Centre. Sydney. Australia. 2School of Life and March Unifying Factor in Insulin Alexis Diaz-Vegas1.2. James Environmental Sciences. The University of Sydney. Sydney. 2021 Resistance Burchfield1.2 Australia

16 13:30 15:00 1 DS 4 NC060 Metformin reduces mitochondrial Aranzazu M. De Aranzazu M. de Marañón1. 1Department of Endocrinology and Nutrition. University March ROS levels and improves Marañón Pedro Díaz-Pozo1. Francisco Hospital Doctor Peset-FISABIO. Valencia. Spain. 2Department 2021 mitochondrial mass membrane Canet1. Teresa Vezza1. Zaida of Physiology. University of Valencia. Valencia. Spain potential and respiratory Abad-Jiménez1. Sandra López- complexes in leukocytes of type 2 Domènech1. Rosa Falcón1. diabetic subjects Celia Bañuls1. Milagros Rocha1. Víctor M. Víctor1.2 Narrated Communications 16 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

16 13:30 15:00 1 DS 4 NC061 Type 1 diabetic patients exhibit Francisco Canet Francisco Canet1. Aranzazu 1Department of Endocrinology and Nutrition. University March enhanced leukocyte-endothelium Martínez de Marañón1. Hospital Doctor Peset-FISABIO. Valencia. Spain. 2Department 2021 interaction and mitochondrial Pedro Díaz-Pozo1. Francesca of Physiology. University of Valencia. Valencia. Spain alterations. Iannantuoni1. Teresa Vezza1. Zaida Abad-Jiménez1. Sandra Lopéz-Domènech1. Rosa Falcón1. Begoña Zaragoza1. Celia Bañuls1. Eva Solá1. Carlos Morillas1. Milagros Rocha- Barajas1. Víctor Víctor1.2

16 13:30 15:00 1 DS 4 NC062 Resveratrol effects on SIRT1- Virginio Bignotti Virginio Bignotti1. Silvano Jr 1Department of Life. Health and Environmental Sciences. March SIRT3-SOD2 axis in high-glucose- Santini1. Valeria Cordone2. University of L’Aquila. L'Aquila. Italy. 2Department of 2021 challenged HUVECs Valeria Panella1. Mahmut Biomedical and Specialist Surgical Sciences. University of Ferrara. Ferrara. Italy Mijit1. Pierpaolo Aimola1. Stefano Falone1. Fernanda Amicarelli1

16 13:30 15:00 1 DS 4 NC063 Involvement of Akt-p38-MAPK/ Gisela Gerardi Gisela Gerardi. Mónica Cavia Department of Biotechnology and Food Science. Faculty of March Nrf2 pathway in prevention of Saiz. Víctor Gutiérrez. Dolores Sciences. University of Burgos. Burgos. Spain 2021 endothelial damage by white-wine Rivero Pérez. Pilar Muñiz pomace product

16 13:30 15:00 2 DS 5 NC064 The research about antioxidant Yugo Kato Yugo Kato. Koji Fukui Molecular Cell Biology Laboratory. Department of Functional March and anti-obesity effects of Control Systems. Graduate School of Engineering and 2021 tocotrienols in high-fat diet- Science. Shibaura Institute of Technology.. Saitama. Japan treated mice

16 13:30 15:00 2 DS 5 NC065 Dietary (-)-epicatechin mitigates Eleonora University of California Davis. Eleonora Cremonini. Maëlys Rouget. Solenne Arredi. March high fat-induced apoptosis Cremonini Davis. USA Charlotte Devulder-Mercier. Robin Cellier. Pauline Pinel. 2021 oxidative and endoplasmic Pierrick Girard. Patricia Oteiza reticulum stress in pancreatic β-cells both in vivo and in vitro

16 13:30 15:00 2 DS 5 NC066 Supplementation with Dario Iglesias Dario Iglesias1. Eleonora 1Departments of Nutrition and Environmental Toxicology. March anthocyanins reverts established Cremonini1. Cesar Fraga2.3. University of California. Davis. CA. USA. 2Physical Chemistry. 2021 endotoxemia in high fat-fed mice Patricia Oteiza1 School of Pharmacy and Biochemistry. University of Buenos Aires. Buenos Aires. Argentina. 3IBIMOL. University through the regulation of colonic of Buenos Aires-CONICET. School of Pharmacy and physiology by modulating redox Biochemistry. University of Buenos Aires. Buenos Aires. signaling Argentina Narrated Communications 16 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

16 13:30 15:00 2 DS 5 NC067 Phenolic compounds from Iris Olha Mykhailenko Olha Mykhailenko1. Michal 1National University of Pharmacy. Department of March hungarica as potential anti- Korinek2.3.4. Bing-Hung Chen4. Pharmaceutical Chemistry. Kharkiv. Ukraine. 2Graduate 2021 inflammatory agents Victoriya Georgiyants1 Institute of Natural Products. College of Medicine. Chang Gung University. Taoyuan 33302. Taiwan. 3Research Center for Chinese Herbal Medicine. Research Center for Food and Cosmetic Safety. and Graduate Institute of Health Industry Technology. College of Human Ecology. Chang Gung University of Science and Technology. Taoyuan 33302. Taiwan. 4Department of Biotechnology. College of Life Science. Kaohsiung Medical University. Kaohsiung City 80708. Taiwan

16 13:30 15:00 2 DS 5 NC068 NADPH oxidase 4 (Nox4) deletion Macarena Herranz Macarena Herranz-Itúrbide1.2. 1TGF-β and Cancer Group. Oncobell Program. Bellvitge March accelerates liver regeneration in Itúrbide Judit López-Luque1.2. Ester Biomedical Research Institute (IDIBELL). L’Hospitalet 2021 mice Gonzalez-Sanchez1.2.3. Daniel de Llobregat. Barcelona. Spain. 2Oncology Program. CIBEREHD. National Biomedical Research Institute on Caballero-Díaz1.2. Eva Crosas- Liver and Gastrointestinal Diseases. Instituto de Salud Molist1.2. Beatriz Martín-Mur4. Carlos III. Madrid. Spain. 3Department of Physiological Marta Gut4.5. Anna Esteve- Sciences. Faculty of Medicine and Health Sciences. Codina4. Vincent Jaquet6.7. University of Barcelona. Barcelona. Spain. 4CNAG-CRG. Joy Xiaosong Jiang8. Natalie J Centre for Genomic Regulation. Barcelona Institute of Török9. Isabel Fabregat1.2.3 Science and Technology. Barcelona. Spain. 5Universitat Pompeu Fabra. Barcelona. Spain. 6Department of Pathology and Immunology. Medical School. University of Geneva. Geneva. Switzerland. 7RE.A.D.S unit. Medical School. University of Geneva. Geneva. Switzerland. 8Gastroenterology and Hepatology. UC Davis. Sacramento. California. USA. 9Department of Internal Medicine. Division of Gastroenterology and Hepatology. Stanford University. Sacramento. California. USA

16 13:30 15:00 2 DS 5 NC069 A novel nutraceuticals mixture Moris Sangineto Moris Sangineto1. Vidyasagar 1C.U.R.E. (University Center for Liver Disease Research March improves oxidative stress by Naik Bukke1. Archana Moola1. and Treatment). Liver Unit. Department of Medical and 2021 reprogramming mitochondrial Rosanna Tamborra1. Francesco Surgical Sciences. University of Foggia. Foggia. Italy. 2Internal Medicine. Department of Medical and Surgical bioenergetics in a non-alcoholic Bellanti2. Loren Duda3. Sciences. University of Foggia. Foggia. Italy. 3Pathology fatty liver disease model Gaetano Serviddio1 Unit. Department of Clinical and Experimental Medicine. University of Foggia. Foggia. Italy

16 13:30 15:00 2 DS 5 NC070 ENNIATINS EFFECT IN RAT Alessandra Alessandra Cimbalo. Manuel University of Valencia. Valencia. Spain March LIVER THROUGH A PROTEOMIC Cimbalo Lozano. Cristina Juan. 2021 APPROACH Guillermina Font. Lara Manyes

16 13:30 15:00 2 DS 5 NC071 Oxidative phosphorylation Jakub Rohlena Silvia Magalhaes Novais1.2*. 1Institute of Biotechnology. Czech Academy of Sciences. March provides stress resistance in non- Jan Blecha1. Katerina Vestec. Prague-West. Czech Republic 2Faculty of Science. 2021 proliferating cells Rohlenova1. Jiri Neuzil1.3. Charles University. Prague. Czech Republic 3School of Medical Science. Griffith University. Southport. Qld. Australia Jakub Rohlena1 Narrated Communications 16 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

16 13:30 15:00 2 DS 5 NC072 Simvastatin prevents IL-1β Giovanni Mann Felipe Freitas. Paul A. Fraser. King's British Heart Foundation Centre of Research March potentiation of bradykinin-induced Giovanni E. Mann Excellence. King's College London. London S1 9NH. United 2021 microvascular permeability in Kingdom intact skeletal muscle: involvement of NADPH oxidase and reactive oxygen species

16 13:30 15:00 2 DS 5 NC073 S-glutathionylation of the Na+-K+ Chia-Chi Liu Chia-chi Liu Vascular Immunology Research Laboratory. The Heart March pump is a novel redox mechanism Research Institute. University of Sydney. Sydney. Australia. 2021 in preeclampsia Kolling Medical Research Institute. Sydney Medical School. University of Sydney. Sydney. Australia

16 13:30 15:00 2 DS 5 NC074 Higher levels of eryptosis Antonio Cilla Tatay Antonio Cilla1. Gabriel López- 1Nutrition and Food Science Area. Faculty of Pharmacy. March and erythrocyte adhesion García1. Víctor Collado-Díaz2. University of Valencia. Burjassot (Valencia). Spain. 2021 to vascular endothelium in María Amparo Blanch-Ruiz2. 2Department of Pharmacology and Physiology. University of Valencia. Valencia. Spain. 3CIBERehd. Valencia. Spain. hypercholesterolemic subjects Guadalupe Garcia-Llatas1. 4Endocrinology and Nutrition Department. Hospital Clínico regardless statin therapy: a pilot Reyes Barberá1. Maria Angeles Universitario. Valencia. Spain. 5Department of Medicine. study Martinez-Cuesta2.3. José T. University of Valencia. Valencia. Spain. 6INCLIVA Institute Real4.5.6.7. Ángeles Álvarez2.3. of Health Research. Valencia. Spain. 7CIBER Diabetes and Sergio Martínez-Hervás4.5.6.7 Associated Metabolic Diseases (CIBERDEM). Madrid. Spain

16 13:30 15:00 2 DS 5 NC075 Early reductive stress followed by a Aitor Carretero Aitor Carretero1. Cesar 1University of Valencia/CIBERFES/INCLIVA. Valencia. Spain. March late onset oxidative stress in acute Rios-Navarro2. Ana Diaz3. 2Hospital Clínico Universitario. Valencia. Spain. 3UCIM. 2021 myocardial infarction Andrea Salvador-Pascual1. Valencia. Spain. 4Université de Montpellier. Montpellier. France Fernando Millan1. Esther Garcia-Dominguez1. Angela Garcia-Correas1. Cristina Garcia-Dominguez1. Adrian De la Rosa1. Coralie Arc- Chagnaud1.4. Gloria Olaso- Gonzalez1. Vicent Bodi2. Mari Carmen Gomez-Cabrera1. José Viña1

16 13:30 15:00 2 DS 5 NC076 Abrogating mitochondrial ROS Carlos Vicente Carlos Vicente-Gutiérrez1.2.3. 1Institute of Functional Biology and Genomics. University of March in neurons or astrocytes reveals Gutiérrez Nicoló Bonora1. Daniel Salamanca. CSIC. Salamanca. Spain. 2Centro de Investigación 2021 cell-specific impact on mouse Jiménez-Blasco1.2.3. Irene Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES). Instituto de Salud Carlos III. Madrid. behaviour López Fabuel1.3. Georgina Spain. 3Institute of Biomedical Research of Salamanca. Bates4. Mike Murphy4. University Hospital of Salamanca. University of Salamanca. Ángeles Almeida1.3. Juan P. CSIC. Salamanca. Spain. 4MRC Mitochondrial Biology Unit. Bolaños1.2.3 University of Cambridge. Cambridge. United Kingdom Narrated Communications 16 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

16 13:30 15:00 2 DS 5 NC077 Establishment of analytical Kyousuke Kyousuke Sugawara. Yuto Tokyo university of technology. Tokyo. Japan March method to detect Coenzyme Sugawara Tanaka. Akari Nakamura. 2021 Q10 level in mitochondrial Tsukika Tanaka. Hikaru Takeuchi. supercomplex Akio Fujisawa. Yorihiro Yamamoto. Misato Kashiba

16 13:30 15:00 2 DS 5 NC078 Mitochondrial ROS contribute Marina Garcia- Marina Garcia-Macia1.2.3. 1Institute of Functional Biology and Genomics (IBFG). March to neuronal ceroid lipofuscinosis Macia Irene Lopez-Fabuel1.2. Universidad de Salamanca. CSIC. Salamanca. Spain. 2Institute 2021 pathogenesis Constantina Buondelmonte1.2. of Biomedical Research of Salamanca (IBSAL).. Salamanca. Spain. 3Centro de Investigación Biomédica en Red de Nicolo Bonora1.2. Brenda Fragilidad y Envejecimiento Saludable (CIBERFES). Madrid. Morant-Ferrando1.2. Paula Spain. 44University Children's Research@Kinder-UKE. Alonso-Batan1.2. Carlos University Medical Center Hamburg Eppendorf. Hamburg. Vicente-Gutierrez1.2.3. Daniel Germany. 55MRC Laboratory for Molecular Biology and GOS Jimenez-Blasco1.2.3. Ruben Institute for Child Health. University College London. London. Quintana-Cabrera1.2.3. Emilio United Kingdom Fernandez1.2.3. Stephan Storch4. Sara E. Mole5. Angeles Almeida1.2. Juan P. Bolaños1.2.3

16 13:30 15:00 2 DS 5 NC079 Oxidative stress-triggered nuclear Irene Sánchez Irene Sánchez-Morán1.2. 1Institute of Functional Biology and Genomics. CSIC - March WRAP53 translocation promotes Morán Cristina Rodríguez1.2. Juan P. University of Salamanca. Salamanca. Spain. 2Institute of 2021 neuronal survival and functional Bolaños1.2. Angeles Almeida1.2 Biomedical Research of Salamanca. University Hospital of Salamanca - University of Salamanca - CSIC. Salamanca. Spain recovery after stroke

16 13:30 15:00 2 DS 5 NC080 Regulation of the extracellular Ángel Juan García Ángel J. García-Yagüe1.2.3.4. 1Centro de Investigación en Red en Enfermedades March matrix glycoprotein Reelin by Yagüe Antonio Cuadrado1.2.3.4 Neurodegenerativas (CIBERNED). Madrid. Spain. 2Instituto 2021 the transcription factor NRF2. de Investigación Sanitaria La Paz (IDIPAZ). Madrid. Spain. 3Instituto de Investigaciones Biomédicas “Alberto Sols” UAM- A protective mechanism for the CSIC. Madrid. Spain. 4Department of Biochemistry. School of brain under oxidative stress Medicine. Autonomous University of Madrid (UAM). Madrid. Spain

16 13:30 15:00 2 DS 5 NC081 Hydrogen peroxide induces neurite Kouji Fukui Koji Fukui. Yugo Kato Shibaura Institute of Technology. Saitama. Japan March degeneration and its phenomenon 2021 relates to neurodegenerative disorders Narrated Communications 17 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

17 14:30 16:00 1 DS 6 NC082 Increased cellular level of Akari Nakamura Akari Nakamura1. Mizuho 1Tokyo University of Technology. Tokyo. Japan. 2Tokai March Coenzyme Q10 during the Okamoto1. Ayaka Maeda1. University. Kanagawa. Japan 2021 differentiation of neuronal cells Kanae Kitatani2. Susumu Takekoshi2. Akio Fujisawa1. Yorihiro Yamamoto1. Misato Kashiba1

17 14:30 16:00 1 DS 6 NC083 Effects of mycotoxins and Manuel Alonso Manuel Alonso-Garrido. University of Valencia. Burjassot. Spain March carotenoids on the blood brain Garrido Massimo Frangiamone. 2021 barrier oxidative stress and Guillermina Font. Lara Manyes mitochondrial gene expression in vitro

17 14:30 16:00 1 DS 6 NC084 Transcriptomic changes after Massimo Massimo Frangiamone. University of Valencia. Valencia. Spain March exposure to pumpkin extract in Frangiamone Lara Alessandra Cimbalo. Manuel 2021 human epithelial cells of a blood Manyes Alonso-Garrido. Guillermina brain barrier model. Font. Lara Manyes

17 14:30 16:00 1 DS 6 NC085 Alteration of cellular defensive Anna Guiotto Anna Guiotto1. Valeria 1Dep.t of Neuroscience and Rehabilitation. University of March response and a possible Cordone1. Mascia Benedusi1. Ferrara. Ferrara. Italy. 2Child Neuropsychiatry Unit. University 2021 involvement of ferroptosis cell Franco Cervellati1. Joussef General Hospital. Azienda Ospedaliera Universitaria Senese. Siena. Italy. 3Department of Translational Medicine and death in Rett syndrome disorder Hayek2. Carlo Cervellati3. for Romagna. University of Ferrara. Ferrara. Italy. 4Plants Giuseppe Valacchi1.4.5. for Human Health Institute. Animal Sciences Dept.. NC Alessandra Pecorelli4 Research Campus. NC State University. Kannapolis. NC. USA. 5Department of Food and Nutrition Kyung Hee University Seoul. Seul. Korea. Republic of

17 14:30 16:00 1 DS 6 NC086 Aberrant NF-κB / Nrf2 cross-talk in Valeria Cordone Valeria Cordone1. Alessandra 1Dept. of Biomedical and Specialist Surgical Sciences. March Rett syndrome Pecorelli2. Anna Guiotto1. University of Ferrara. Ferrara. Italy. 2Dept. of Animal 2021 Mascia Benedusi3. Carlo Sciences. Plant for Human Health Institute. North Carolina Research Campus. Kannapolis. USA. 3Dept. of Biomedical Cervellati1. Fernanda and Specialist Surgical Sciences. University of Ferrara. Ferrara. Amicarelli4. Joussef Hayek5. Jersey. 4Dept. of Life. Health and Environmental Sciences. Giuseppe Valacchi1.2.6 University of L’Aquila. L'Aquila. Italy. 5Child Neuropsychiatry Unit. Azienda Ospedaliera Universitaria Senese. Siena. Italy. 6Dept. of Food and Nutrition. Kyung Hee University. Seoul. Korea. Republic of

17 14:30 16:00 1 DS 6 NC087 An antioxidant-enriched diet Noemi Ceprian Noemí Ceprián1.2. Blanca 1Dept. Genetics. Physiology. Microbiology (Animal Physiology March improves the behavior immunity Costoso García-Solís1. Lucía Vacas1. Unit). Fac. Biology. Complutense University of Madrid. 2021 and oxidative stress in a mouse Lydia Gimenez-Llort3. Mónica Madrid. Spain. 2Institute of Investigation 12 de Octubre (i+12). Madrid. Spain. 3Department of Psychiatry and model of Alzheimer’s Disease. De la Fuente1.2 Forensic Medicine. Institute of Neurosciences. Universitat Autonoma of Barcelona. Bellaterra. Spain Narrated Communications 17 March 2021 *DS = Discussion Session

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17 14:30 16:00 1 DS 6 NC088 Pilot study: contributing to AD Aurora Román- Aurora Román-Domínguez. Universidad de Valencia. Valencia. Spain March diagnosis with a novel set of non- Domínguez Cristina Mas-Bargues. Mar 2021 invasive biomarkers Dromant. Paloma Monllor. Consuelo Borrás. José Viña

17 14:30 16:00 1 DS 6 NC089 Altered inflammation and redox Antonio Cuadrado Antonio Cuadrado1.2.3.4. Elena 1“Victor Babes” National Institute of Pathology. Bucharest. March networks in the blood of patients Milanesi1. Maria Dobre1. Anca Romania. 2Instituto de Investigaciones Biomédicas "Alberto 2021 with mild dementia Cucos1. Gerard Piñol-Ripoll5. Sols" UAM-CSIC. Department of Biochemistry. Faculty of Medicine. Autonomous University of Madrid (UAM). Catalina Tudose6. Gabriela Madrid. Spain. 3Centro de Investigación Biomédica en Red Niculescu7. Gina Manda1 Sobre Enfermedades Neurodegenerativas (CIBERNED). Madrid. Spain. 4Instituto de Investigación Sanitaria La Paz (IdiPaz). Madrid. Spain. 5Unitat Trastons Cognitius. Hospital Universitari Santa Maria-IRBLleida. Lleida. Spain. 6Alexandru Obregia Clinical Hospital of Psychiatry & The Memory Centre of the Romanian Alzheimer Society.. Bucharest. Romania. 7Medinst Diagnostic & Polytechnic University of Bucharest. Bucharest. Romania

17 14:30 16:00 1 DS 6 NC090 Disruption of neurovascular Cátia Lourenço Cátia F. Lourenço1.2. João 1Center for Neuroscience and Cell Biology. University March coupling in a rodent model of Marques Gonçalves3.2. José Sereno4. of Coimbra.. Coimbra. Portugal. 2Faculty of Pharmacy. 2021 vascular dementia – can we rescue João Sargento-Freitas5. University of Coimbra. Coimbra. Portugal. 3Center for Neuroscience and Cell Biology. University of Coimbra. it by nitrate supplementation? Miguel Castelo-Branco4. João Coimbra. Portugal. 4CIBIT/ICNAS Institute for Nuclear Laranjinha1.2 Sciences Applied to Health. Coimbra. Portugal. 5Dept. Neurology. Coimbra University Hospital. Coimbra. Portugal

17 14:30 16:00 1 DS 6 NC091 A blueberry anthocyanin extract Diana Serra Diana Serra1.2. Joana 1CNC-Center for Neuroscience and Cell Biology. Coimbra. March still reduces microglial activation Henriques1.2. Teresa Serra3.4. Portugal. 2Faculdade de Farmácia. Universidade de Coimbra. 2021 after simulated digestion Andreia Bento Silva5. Maria Coimbra. Portugal. 3IBET—Instituto de Biologia Experimental e Tecnológica. Oeiras. Portugal. 4ITQB—Instituto de Rosário Bronze4.5. Teresa Tecnologia Quimica e Biologica Antonio Xavier. Universidade Dinis1.2. Leonor Almeida1.2 Nova de Lisboa. Oeiras. Portugal. 5Faculdade de Farmácia. Lisboa. Portugal

17 14:30 16:00 1 DS 6 NC092 Mitochondrial dysfunction fuels Alessandra Alessandra Pecorelli1. Valeria 1North Carolina State University. Plants for Human Health March inflammasome machinery in Pecorelli Cordone2. Anna Guiotto2. Institute. Kannapolis. NC. USA. 2University of Ferrara. 2021 Autism Spectrum Disorder Franco Cervellati2. Mascia Department of Life Sciences and Biotechnology. Ferrara. Italy. 3University of Ferrara. Department of Morphology. Benedusi2. Carlo Cervellati3. Surgery and Experimental Medicine. Ferrara. Italy. 4Child Joussef Hayek4. Giuseppe Neuropsychiatry Unit. University General Hospital. Azienda Valacchi1.2.5 Ospedaliera Universitaria Senese. Siena. Italy. 5Kyung Hee University. Department of Food and Nutrition. Seoul. Korea. Republic of Narrated Communications 17 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

17 14:30 16:00 1 DS 6 NC093 The beneficial effect of an Joana Henriques Joana Henriques1.2. Diana 1CNC—Center for Neuroscience and Cell Biology. University March anthocyanin-rich extract from Serra1.2. Mariana Laranjo1.3. of Coimbra. Coimbra. Portugal. 2Faculty of Pharmacy. 2021 Portuguese blueberries on João Peça1.4.5. Teresa Dinis1.2. University of Coimbra. Coimbra. Portugal. 3PhD Program in Experimental Biology and Biomedicine (PDBEB). University behavioral molecular and cellular Leonor Almeida1.2 of Coimbra. Coimbra. Portugal. 4Institute for Interdisciplinary alterations in prenatal valproic Research. University of Coimbra. Coimbra. Portugal. acid-induced mice model of autism 5Department of Life Sciences. University of Coimbra. Coimbra. Portugal

17 14:30 16:00 1 DS 6 NC094 Regulation of the Nrf2-Notch1 axis Giovanni Mann Emily Boorman1. Patricia 1King's BHF Centre of Research Excellence. King's College March in neurons: a role in neurogenesis Zunszain2. Richard Killick2. London. London SE1 9NH. United Kingdom. 2Maurice Wohl 2021 Giovanni E. Mann1 Institute. Institute of Psychology. King's College London. London SE5 9RT. United Kingdom

17 14:30 16:00 1 DS 6 NC096 The Association of the Glutathione Guillermo Sáez María Amparo Martínez- 1Service of Clinical Analysis. University Hospital Dr. March Redox State with Colorectal Cancer Tormo Santamaría1. Delia Acevedo- Peset-FISABIO.. Valencia. Spain. 2Research Unit. Service 2021 and its Effectiveness as a Tumor León1. Celia Bañuls-Morant2. of Endocrinology and Nutrition. University Hospital Dr. Peset-FISABIO. Valencia. Spain. 3Dept. of Biochemistry and Marker. Lidia Monzó-Beltran3. Nuria Molecular Biology. Faculty of Medicine and Odontology. Estañ-Capell1. María Ruiz- University of Valencia.. Valencia. Spain. 4Service of General Luque1. Segundo Ángel Surgery. University Hospital Dr. Peset.. Valencia. Spain. Gómez-Abril4. Marisa Pérez- 5Service of Pathological Anatomy. University Hospital Dr. Ebri5. Jorge Escandón-Álvarez5. Peset.. Valencia. Spain. 6Center for Molecular Recognition Eulalia Alonso-Iglesias3. Marisa and Technological Development. Mixed Unit Polytechnic University-University of Valencia.. Valencia. Spain. 7Dept. of Santaolaria-Ayora1. Araceli Medicine. University of Valencia.. Valencia. Spain Carbonell-Moncho1. María José Vila-Planells1. Pablo Blas-Blasco6. Carmen Martínez- Bisbal6. Leticia Bagán-Debón7. Ramón Martínez-Mañez6. Guillermo Sáez Tormo1.3

17 14:30 16:00 1 DS 6 NC095 Hyperoxidation of Peroxiredoxin Jiao Meng Jiao Meng1. Chang Chen1 National Laboratory of Biomacromolecules. Institute of March 2 Leads to Redox-Response Biophysics. Chinese Academy of Sciences. Beijing 100101. 2021 Resistance (RRR) in Senescent Cells China

17 14:30 16:00 2 DS 7 NC097 Androgen-dependent prostate Isabel Quiros Isabel Quiros-Gonzalez1. 1Morfología y Biología Celular. IUOPA. ISPA. Universidad de March cancer cells reprogram their Gonzalez Pedro Gonzalez-Menendez2. Oviedo. Oviedo. Spain. 2Institute de la Genetique Moleculier. 2021 metabolic signature upon Glut-1 Sergio Alcon-Rodriguez1. David Université de Montpellier. Montpellier. France upregulation by Manganese Hevia1. Rosa M. Sainz1. Juan C. Superoxide Dismutase (Mnsod/ Mayo1 SOD2). Narrated Communications 17 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

17 14:30 16:00 2 DS 7 NC098 Sensitization of Melanoma Cells Yingjie Chen Ying-Jie Chen. Anfernee Kai- School of Chinese Medicine. Hong Kong Baptist University. March to Nitrosourea Treatment by Wing Tse. Xiu-Qiong Fu. Tao Su. Hong Kong. Hong Kong 2021 Orchestrating Oxidative Stress and Zhi-Ling Yu IKKβ Inhibition

17 14:30 16:00 2 DS 7 NC099 δ-tocotrienol triggers ROS/MAPK Fabrizio Fontana Fabrizio Fontana. Monica University of Milan. Milan. Italy March axis-mediated apoptosis in ovarian Marzagalli. Michela Raimondi. 2021 cancer cells Patrizia Limonta

17 14:30 16:00 2 DS 7 NC100 Relevance of mitochondrial Patricia De La Cruz Patricia de la Cruz-Ojeda1. 1Institute of Biomedicine of Seville (IBIS). IBiS/Hospital March dysfunction during Sorafenib- Ojeda M. Ángeles Rodríguez- University “Virgen del Rocío”/CSIC/University of Seville. 2021 induced cell death in liver cancer Hernández1.2. Elena Seville. Spain. 2Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd). Madrid. Spain. cells. Role of oxidative and Navarro-Villarán1.2. Paloma 3Department of Physiology. Faculty of Medicine in Hradec nitrogen reactive species Gallego1. Pavla Staňková3.4. Kralove. Charles University. Hradec Kralove. Czech Republic. José A. Del Campo1.2. Otto 4COST-European Cooperation in Science & Technology. Kučera3.4. Moustafa Elkalaf3. Mitoeagle Action number: CA15203. Hradec Kralove. Tumisang E. Maseko3. Czech Republic. 5Department of General Surgery. Hospital Zuzana Červinková3.4. Jordi University “Virgen del Rocío”/IBiS/CSIC/University of Seville. Seville. Spain Muntané1.2.4.5

17 14:30 16:00 2 DS 7 NC101 WIP induces oxidant tolerance in Diego Lastra Diego Lastra1.2.3.4. Natalia 1Department of Biochemistry. Faculty of Medicine. March glioblastoma cells through NRF2/ Robledinos-Antón1.2.3.4. Autonomous University of Madrid.. Madrid. Spain. 2Instituto 2021 KEAP1 axis regulation Antonio Cuadrado1.2.3.4. de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC.. Madrid. Spain. 3Instituto de Investigación Sanitaria La Paz Maribel Escoll1.2.3.4 (IdiPaz). Madrid. Spain. 4Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED). Madrid. Spain

17 14:30 16:00 2 DS 7 NC102 Oxygen independent generation Ken-Ichiro Ken-ichiro Matsumoto. Ikuo National Institute of Radiological Sciences. Quantum Medical March of hydrogen peroxide in water Matsumoto Nakanishi. Yasushi Abe. Shinji Science Directorate. National Institutes for Quantum and 2021 irradiated by carbon-ion beam Sato. Masayuki Muramatsu. Radiological Science and Technology. Chiba. Japan Ryosuke Kohno. Dousatsu Sakata. Kota Mizushima. Hideyuki Mizuno. Taku Inaniwa

17 14:30 16:00 2 DS 7 NC103 Highly fluorescent chiral N-S- Guangjun Nie Yiye LI1*. Feng Li2. Huaping 1CAS Key Laboratory for Biomedical Effects of Nanomaterials March doped carbon dots from Xu3. Guangjun Nie1 and Nanosafety. National Center for Nanoscience and 2021 cysteine: Affecting cellular energy Technology. Beijing. P. R. China 2Frontier Science Center for Synthetic Biology. Key Laboratory of Systems Bioengineering. metabolism School of Chemical Engineering and Technology. Tianjin University. Tianjin. P.R. China 3Key Lab of Organic Optoelectronics & Molecular Engineering. Department of Chemistry. Tsinghua University. Beijing. P. R. China Narrated Communications 17 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

17 14:30 16:00 2 DS 7 NC104 Effect of reaction media on Ikuo Nakanishi Ikuo Nakanishi1*. Yoshimi 1National Institute of Radiological Sciences (NIRS). Quantum March the scavenging reaction of Shoji1. Kei Ohkubo1.2.3. Medical Science Directorate. National Institutes for Quantum 2021 water-solubilized 22-diphenyl-1- Toshihiko Ozawa4. Ken- and Radiological Science and Technology (QST). Chiba. Japan 2Institute for Advanced Co-Creation Studies. Osaka picrylhydrazy radical by ascorbic ichiro Matsumoto1. Shunichi University. Osaka. Japan 3Open and Transdisciplinary acid Fukuzumi5 Research Initiatives. Osaka University. Osaka. Japan 4Nihon Pharmaceutical University. Saitama. Japan 5Graduate School of Science and Technology. Maijo University. Aichi. Japan

17 14:30 16:00 2 DS 7 NC105 Therapeutic potential of nitric Rosana Pinto Rosana Pinto1.2. Sujing Wang3. 1CERENA. Departamento de Engenharia Química. Instituto March oxide released by a robust NO Sergio Tavares4. João Pires2. Superior Técnico. Universidade de Lisboa. Lisboa. Portugal. 2021 carrier based on a porous Ti-MOF Fernando Antunes2. Alexandre 2Centro de Química Estrutural. Faculdade de Ciências. Universidade de Lisboa. Lisboa. Portugal. 3Institut des Vimont5. Guillaume Clet5. Matériaux Poreux de Paris. UMR 8004 CNRS. Ecole Marco Daturi5. Guillaume Normale Supérieure. Ecole Supérieure de Physique et de Maurin4. Christian Serre3. Chimie Industrielles de Paris. PSL University. Paris. France. Moisés Pinto1 4Institut Charles Gerhardt Montpellier UMR 5253 CNRS. Université de Montpellier. Montpellier. France. 5Normandie Univ. ENSICAEN. UNICAEN. CNRS. Laboratoire Catalyse et Spectrochimie. Caen. France

17 14:30 16:00 2 DS 7 NC106 Alteration of redox state following Takahiro Kataoka Takahiro Kataoka1. Norie 1Graduate School of Health Sciences. Okayama University. March radon inhalation depends on the Kanzaki2. Akihiro Sakoda2. Okayama. Japan. 2Ningyo-toge Environmental Engineering 2021 antioxidant capacity of organs Hina Shuto1. Junki Yano1. Center. Japan Atomic Energy Agency. Okayama. Japan. 3Advanced Science Research Center. Okayama University. Shota Naoe1. Hiroshi Tanaka2. Okayama. Japan. 4Graduate School of Medicine Dentistry Katsumi Hanamoto1. Hiroaki and Pharmaceutical Sciences. Okayama University. Okayama. Terato3. Fumihiro Mitsunobu4. Japan Kiyonori Yamaoka1

17 14:30 16:00 2 DS 7 NC107 Low-dose irradiation reduces Takahiro Kataoka Shota Naoe1. Takahiro 1Graduate School of Health Sciences. Okayama University. March forced swim test-induced Kataoka1. Hina Shuto1. Junki Okayama. Japan. 2National Cerebral and Cardiovascular 2021 immobility and oxidative stress in Yano1. Tetsuya Nakada1. Center. Osaka. Japan. 3Central Research Institute of Electric Power Industry. Tokyo. Japan mice Tsuyoshi Ishida1. Keiko Yamato2. Katsumi Hanamoto1. Takaharu Nomura3. Kiyonori Yamaoka1

17 14:30 16:00 2 DS 7 NC108 Redox regulation of autophagy by Francisca Sevilla Sabrina de Brasi-Velasco. Omar Dpt of Stress Biology and Plant Pathology. CEBAS-CSIC. March thioredoxin o1 and its involvement López-Vidal. María Carmen Murcia. Spain 2021 in tobacco BY-2 cell viability under Martí. Ana Jiménez. Francisca oxidative conditions Sevilla Narrated Communications 17 March 2021 *DS = Discussion Session

Date ETS ETF Ch Session ID Title Speaker Name Authors (COM) Institution

17 14:30 16:00 2 DS 7 NC109 In vitro cytoprotective effect and Mercedes Mercedes Taroncher Ruiz1. 1Faculty of Pharmacy. Valencia. Spain. 2Department of March antioxidant capacity of salmon Taroncher Ruiz Tone Aspevik2. Katerina Nutrition and Feed Technology. Bergen. Norway 2021 mackerel and herring hydrolysates Kousoulaki2. Francisco Barba1. in Caco-2 clone (TC7) cells María-José Ruiz1

17 14:30 16:00 2 DS 7 NC110 Detection of active cell death Yoana Exposito Joana R. Expósito Piñero. Irene Universidad Rey Juan Carlos. Móstoles. Spain March markers in rehydrated lichen thalli Mejuto. Myriam Catalá 2021 and the involvement of nitrogen monoxide (NO).

17 14:30 16:00 2 DS 7 NC111 Immunomodulation of melanoma Sander Bekeschus Sander Bekeschus ZIK plasmatis. Leibniz Institute for Plasma Science and March in vitro and in vivo using reactive Technology. Greifswald. Germany 2021 oxygen species

17 14:30 16:00 2 DS 7 NC112 Inhibiting Bach1 enhanced the Henry Jay Forman Hongqiao Zhang1. Natalie "1Leonard Davis School of Gerontology. University of March activation of Nrf2 signaling and the Lyn2. Mafalda Cacciottolo1. Southern California. Los Angeles. USA 2021 degradation of HNE in response to Amirhosein H Mousavi3. 2 Dornsife College. University of Southern California. Los Angeles. USA oxidative stress Constantinos Sioutas3. Todd E 3 Viterbi School of Engineering. University of Southern Morgan1. Caleb E Finch1. Henry California. Los Angeles. USA" Jay Forman1

17 14:30 16:00 2 DS 7 NC113 Apolipoprotein E4 and Oxidative José Viña Mariana Nepomuceno. Paloma Department of Biochemistry. Rappaport Institute for March Stress: A Prospective Study Monllor. Daniel Esteve. José Research in the Medical Sciences. Faculty of Medicine. 2021 Viña and Ana Lloret. Technion Israel Institute of Technology. Haifa. Israel

17 14:30 16:00 2 DS 7 NC114 The SGAs Olanzapine and María Monsalve Laura Doblado1. Gaurangkumar "1 Instituto de Investigaciones Biomédicas Alberto Sols. March Aripiprazole inhibit mitocondrial Patel1. Ramazan Yildiz1. Madrid. Spain 2021 respiration and induce oxidative Letizia Sellinger2. Dora Koller3. 2 Department of Biochemistry. Federal University of Santa Catarina. Florianopolis. SC. Brazil. stress Francisco Abad Santos3. Belén 3 Instituto de Investigación Sanitaria La Princesa. Madrid. Peral1. Andreza Fabro de Ben2. Spain" María Monsalve1.

17 14:30 16:00 2 DS 7 NC115 Antagonistic regulation of Moran Benhar Moran Benhar Department of Biochemistry. Rappaport Institute for March apoptosis by polysulfides and Research in the Medical Sciences. Faculty of Medicine. 2021 thioredoxin via persulfidation of Technion Israel Institute of Technology. Haifa. Israel caspases