www.iscort.org.il

Scientific Program

08.01.2019 - 12.01.2019, ,

The Annual Meeting of The Israeli Society for Clinical Oncology and Radiation Therapy ISCORT wishes to express its gratitude to the following companies הוועדה המארגנת for their support of the 19th ISCORT Annual Meeting: Organizing Committee ISCORT 19 נשיא הכנס: :President פרופ׳ סלומון שטמר Platinum Sponsor Salomon M. Stemmer, MD Roche מזכירת הכנס: :Secretory ד״ר ולריה סמניסטי Gold Sponsor Valeria Semenysty, MD יו"ר הרדיותרפיה: :BMS Radiation Oncology Co-Chair פרופ׳ בן קורן MSD Ben W. Corn, MD Pfizer הוועדה המדעית Scientific Committee ISCORT 19 Silver Sponsor יו"ר: פרופ' מיכל לוטם Astellas Chairman: Michal Lotem, MD ד״ר אהרון אלון Astrazeneca Aaron Allen, MD ד״ר נועם אסנה Boehringer Ingelheim Noam Asna, MD ד״ר יאיר בר Eli Lilly Jair Bar, MD PhD ד״ר יהונתן כהן ISI Yonathan Cohen, MD PhD פרופ׳ בן קורן Novartis Ben W. Corn, MD ד״ר אלה עברון Rafa Ella Evron, MD ד״ר דניאלה כץ Daniela Katz, MD פרופ׳ גל מרקל Bronze Sponsor Gal Markel, MD PhD ד״ר אינה אוספובט AbbVie Inna Ospovat, MD ד״ר אביבית פאר Assuta Avivit Peer, MD ד״ר רות פרץ Bayer Ruth Perets, MD PhD Bolpharma ד״ר רפאל פפר Raphael Pfeffer, MD Dexcel Pharma ד״ר קרן רובינוב Keren Rouvinov, MD Isotopia ד״ר יקטרינה שולמן Katerina Shulman, MD Medison ד״ר אמיר זוננבליק Merck Amir Sonnenblick, MD ד״ר מרק ויגודה Nanostring Marc Wygoda, MD ד״ר אלונה זר Neopharm Alona Zer, MD ד״ר אביעד זיק Oncotest-Teva Aviad Zik, MD Perrigo החברה המארגנת Sanofi Organizing Company א.מ. כנסים בע"מ .Takeda I.M. Knasim Ltd חברים נכבדים, ,Dear friends and colleagues ברוכים הבאים לכנס השנתי של האיגוד הישראלי לאונקולוגיה קלינית Welcome to the 19th annual meeting of the Israel Society for Clinical ורדיותרפיה )ISCORT 19th( המתקיים באילת ב- 12-8 בינואר Oncology and Radiotherapy (ISCORT) to be held in Eilat on January 8-12, .2019 הכנס השנתי של ISCORT מארח את מרבית הצוותים המעורבים ועוסקים .2019 בטיפול ובמחקר במחלות הסרטן. כולנו עמלים יומם וליל במטרה לטייב את .The ISCORT annual meeting hosts the majority of Israeli teams in the field הטיפול על כל מרכיביו, שיפור בהישרדות והקטנת תופעות הלוואי, במטרה ,All of us are dedicated to the treatment of cancer patients, enhancing care להאריך את החיים ולשפר את איכות החיים של החולה, משפחתו והחברה improving outcome and reducing toxicity. We strive to improve the quality כולה. במקביל אנו עמלים על הוראה נטולת הטיות והנגשת הטיפול המיטבי of life for the patient, family members and society. We seek to promote לכל תושבי מדינת ישראל. unbiased education and improve access to optimal and affordable cancer בכנס שאירגנו לשנה זו תועלנה מספר סוגיות בנוגע למורכבות הטיפול בחולה .care במאה הThis year’s program emphasizes the complexity of cancer care in the 21st .21- בשנים האחרונות אנו חווים התפוצצות מידע עם גילוי יותר תרופות ״מוכוונות .century מטרה״, הפעלת המערכת החיסונית על יתרונותיה וחסרונותיה, ונסיון כן During the last years we have witnessed the rapid unfolding of cancer להקטנת תחלואה. חדשנות מביאה לשינוי תפיסה לגבי טיפולים מוכווני מטרה research, targeted therapy, as well as the advantages and limitations of the ולא מוכווני האיבר שבו נוצר הגידול. התובנות החדשות, בין השאר של גופים powerful immune system. Innovations in most areas of treatment have led to an agnostic approach with faster and more comprehensive drug approval רגולטורים, הביאו גם לקיצור בזמנים להבאת טכנולוגיות חדשות לחולים. by regulatory agencies. אנו חסרים עדיין תובנות רחבות יותר לגבי יחסי גומלין בין מחלה לחולה, בין גוף We are still on a quest for the ideal treatment, tailored to the specific human לנפש, מגדר ומגזר, התנהגות ואמונה. חדשנות ואינטרגרציה עשויים לשפר את being with his/her unique physiology, psychology, ethnicity, behavior and הטיפול בחולים שלנו. הרפואה והבריאות חשובים ביותר בחיי הפרט והחברה. belief. Novelty and integration will surely bring our patients to the best מכאן חובתינו להתיחס גם למרכיבים כלכליים של הטיפול. על כן יכלול הכנס possible outcome. Yet all novel approaches must be placed in a framework השנה מושבים קצרים בנושא של ״ערך הטיפול בסרטן״ מנקודת מבט כלכלית. of value to the individual patient as well as society. Therefore, we will have פתחנו מושבים של ״פגוש את המומחה״ המיועדים למתמחים ולמומחים .short sessions that will provide such context צעירים, שבהם יוכלו לדון במקרים בעייתיים עם האורחים הבינלאומיים ,For the residents and young faculty we launched a new format for ISCORT שמגיעים לכנס. Meet the Professor”, where participants are encouraged to present“ אנו מודים לכל העושים במלאכה להצלחת הכנס, ולחברי הוועדה המדעית, על challenging cases or to pose professional dilemmas to our distinguished עבודתם לבחירת מיטב התקצירים שיוצגו בכנס. .guests לסיום נזכיר, היות והכנס מסונף ל-ESMO, כנס בינלאומי, כל ההרצאות We thank all members who participated in the organization of the meeting והמושבים יתנהלו בשפה האנגלית. and scientific committee members for selecting the best abstracts to be shared by us. מאחלים לכולנו כנס פורה, מוצלח ומהנה, Looking forward to a great conference,

שלום, ,Shalom פרופ׳ סלומון שטמר פרופ׳ מיכל לוטם Salomon M Stemmer, MD Michal Lotem, MD נשיא יו״ר ועדה מדעית President Head of Scientific Committee פרופ׳ בן קורן ד״ר ולריה סמניסטי Ben W. Corn, MD Valerie Semenysty, MD יו"ר הרדיותרפיה מזכירה Radiation Oncology Co-Chair Secretory 18:10-18:50 Keynote Lecture Tuesday, January 8, 2019 Moderator: Gil Bar-Sela, MD Haemek Medical Center, , Israel 17:00–19:30 Opening Session Moving from precision to next Moderator: Valeria Semenysty, MD generation healthcare Rambam Medical Center , Israel Joel Dudley, PhD 17:00-17:20 Welcome Associate Professor of Genetics and Genomic Salomon M. Stemmer, MD Sciences Davidoff Center, , Petach Director of the Institute for Next Generation Tikva, Israel Healthcare Mount Sinai Endowed Professor of Biomedical Wilmush Mermershtain, MD Data Science ISCORT Icahn School of Medicine at Mount Sinai 17:20-17:30 Resident Recognition Award Executive Vice President for Precision Health Mrs. Miri Ziv, CEO Mount Sinai Israel Cancer Association, Givatayim, Israel New York, USA Supported by ISCORT and MSD 17:30-18:10 Best ISCORT Abstract Awards 18:50-19:30 Keynote Lecture Moderator: Michal Lotem, MD Moderator: Nir Peled, MD PhD , Israel , Beer Sheva, Israel Neoadjuvant pembrolizumab (Pembro) for early Clinical trials, personalized medicine and stage non-small cell lung cancer (NSCLC) – relationships with pharma: Time for reflection? initial report of a phase I study, MK3475-223 Ian Tannock, MD Jair Bar, MD PhD Emeritus professor of Medical Oncology and , Ramat-Gan, Israel Medical Biophysics Prophylactic irradiation to the contralateral Princess Margaret Cancer Center breast for BRCA mutation carriers with early and University of Toronto, Canada mammary cancer Supported by ISCORT Ella Evron, MD , , Israel 19:30 Dinner A functional variant of the estrogen receptor: A potential novel driver of pancreatic cancer Ido Wolf, MD Sourasky Medical Center, Tel-Aviv, Israel Discussion and perspectives Michal Lotem, MD Hadassah Medical Center, Jerusalem, Israel Understanding the pathway in prostate cancer, Wednesday, January 9, 2019 present and future Johann de-Bono, MD 07:30-08:15 Meet the Professor The Institute of Cancer Research and The Royal Lung Cancer Marsden NHS Foundation Trust, London, England Tarshish B Hall Supported by Astellas and Janssen Moderators: Mor Moshkovich, MD 09:00-09:25 Sponsored Lecture Rambam Medical Center, Haifa, Israel Moderators: Victoria Neiman, MD Abed Agbarya, MD Davidoff Center, Rabin Medical Center , Haifa, Israel Petach Tikva, Israel Francis Shepherd, MD Keren Rouvinov, MD Department of Medicine at the University of Soroka Medical Center, Beer Sheva, Israel Toronto, Canada 2019 NHB - New treatment paradigm in RCC Supported by MSD Daniel Keizman, MD Prostate Cancer Meir Medical Center, , Israel Tarshish A Hall Supported by BMS Moderators: Noa Shani Shrem, MD 09:25-09:35 Value of Cancer Care Soroka Medical Center, Beer Sheva, Israel Moderator: Raya Leibowits, MD PhD David Sarid, MD ISCORT Basket Committee Sourasky Medical Center, Tel-Aviv, Israel Daniel Goldstein, MD Johann de-Bono, MD Davidoff Center, Rabin Medical Center The Institute of Cancer Research and The Royal Petach Tikva, Israel Marsden NHS Foundation Trust, London, England 09:35-10:15 Tumor Board: Urological Malignancies Supported by ASTELLAS Moderator: Avishay Sella, MD Genito-Urinary Malignancies – General Session Shamir (Asaf Harofe) Medical Center, , Israel 08:20-09:00 Keynote Lecture Panel: Johann de-Bono, MD Moderators: Eli Rosenbaum, MD The Institute of Cancer Research and The Royal Davidoff Center, Rabin Medical Center Marsden NHS Foundation Trust, London, England Petach Tikva, Israel Wilmush Mermershtein, MD Avivit Peer, MD Soroka Medical Center, Beer Sheva, Israel Rambam Medical Center, Haifa, Israel Raanan Berger, MD PhD Sheba Medical Center, Ramat-Gan, Israel Avivit Peer, MD Preliminary results from microbiome-based phase Rambam Medical Center, Haifa, Israel I clinical trial - fecal microbiota transplantation Eli Rosenbaum, MD in metastatic melanoma patients who failed Davidoff Center, Rabin Medical Center immunotherapy (NCT03353402) Petach Tikva, Israel Gal Markel, MD PhD Sheba Medical Center, Tel Hashomer, Israel 10:15-10:30 Coffee Break 11:10-11:30 Sponsored Lecture 10:30-11:10 Original Abstracts: GU and Melanoma Moderator: Ronen Brenner, MD Moderators: Maya Kolin, MD , Bat-Yam, Israel Rambam Medical Center, Haifa, Israel MORPEHEUS: Novel clinical trial design for Yonathan Cohen, MD PhD immunotherapy combinations Hadassah Medical Center, Jerusalem, Israel Julie Maltzman, MD Genomic analysis of urothelial cancer and Group Medical Director associations with treatment choice and outcome – Genentech a Member of The Roche Group, CA, USA collaborative research from the Israeli GU Supported by Roche oncology group 11:30-12:10 Tumor Board: Precision Oncology Raya Leibowitz MD PhD Sheba Medical Center, Ramat-Gan, Israel Moderator: Tamar Peretz, MD Hadassah Medical Center, Jerusalem, Israel Short term androgen deprivation therapy with/ without pelvic lymph node treatment added to Panel: Dov Hershkovitz, MD prostate bed only salvage radiotherapy: RTOG 0534 Sourasky Medical Center, Tel-Aviv, Israel Aron Allen, MD Nir Peled, MD PhD Davidoff Center, Rabin Medical Center Soroka Medical Center, Beer Sheva, Israel Petach Tikva, Israel Raanan Berger, MD PhD Ipilimumab-Nivolumab combination therapy Sheba Medical Center, Ramat-Gan, Israel in metastatic melanoma patients who have Eitan Rubin, PhD Senior Researcher progressed on previous anti PD-1 therapy Ben Gurion University, Beer Sheva, Israel Guy Ben-Betzalel, MD Sheba Medical Center, Ramat-Gan, Israel Doron Lipson, PHD VP Research & Early Development Brain derived melanoma cells suppress expression Foundation Medicine Inc., Cambridge, USA of key transcripts in tumor infiltrating lymphocytes Supported by Roche as compared with melanoma from visceral metastases 12:10-13:00 Lunch Jonathan Cohen, MD PhD Hadassah Medical Center, Jerusalem, Israel Lung Cancer - General Session The association between proton pump inhibitors 13:00-13:40 Keynote Lecture use and lung cancer risk: A nested case-control Moderator: Alona Zer, MD study Davidoff Center, Rabin Medical Center Hadas Dresler, MD Petach Tikva, Israel Meir Medical Center, Kfar Saba, Israel Understanding the pathway in lung cancer Osimertinib for patients with EGFR-positive Frances Shepherd, MD advanced non-small cell lung cancer and Department of Medicine at the University of asymptomatic brain metastasis: preliminary Toronto, Canada analysis of an open label two arm phase II study Supported by MSD Nir Peled, MD PhD 13:40-14:05 Sponsored Lecture Soroka Medical Center, Beer Sheva, Israel Moderators: Yulia Dudnik, MD A single MAPK/Erk phosphorylation site dictates Soroka Medical Center, Beer Sheva, Israel distinct functions of highly homologous co- repressors Ofer Merimsky, MD Hovav Nechushtan, MD PhD Sourasky Medical Center, Tel-Aviv, Israel Hadassah Medical Center, Jerusalem, Israel Stage III non small cell lung cancer, new paradigm EF hand domain family member D2 is required Scott J. Antonia, MD PhD for T cell cytotoxicity Thoracic Oncology Department, H.Lee Moffitt Amir Onn, MD Cancer Center and Research Institute, Tampa Sheba Medical Center, Ramat-Gan, Israel Florida , USA 15:05-15:45 Tumor Board: Lung Malignancies Supported by Astra Zeneca Moderator: Jair Bar, MD PhD 14:05-14:25 Sponsored Lecture Sheba Medical Center, Ramat-Gan,Israel Moderator: Hovav Nechushtan, MD PhD Panel: Maya Gottfried, MD Hadassah Medical Center, Jerusalem, Israel Meir Medical Center, Kfar Saba, Israel Next generation targeted therapies: Sequencing Damian Urban, MD challenges or best drug first? Sheba Medical Center, Ramat-Gan Israel Maya Gottfried, MD Frances Shepherd, MD Meir Medical Center, Kfar Saba, Israel Department of Medicine, Toronto University Supported by Astra Zeneca and Takeda Canada 14:25-15:05 Original Abstracts: Lung and Basic Science Uzi Izhar, MD Moderators: Elizabeth Dudnik, MD Hadassah Medical Center, Jerusalem, Israel Davidoff Center, Rabin Medical Center Raphael Pfeffer, MD Petach Tikva, Israel , Tel-Aviv, Israel Mira Wollner, MD Supported by BI Rambam Medical Center, Haifa, Israel 15:45-16:00 Coffee Break 17:05-17:45 Tumor Board: Brain Metastasis 16:00-16:25 Sponsored Lecture Moderators: Shlomit Yust, MD Moderator: Noam Asna, MD Davidoff Center, Rabin Medical Center , , Israel Petach Tikva, Israel The evolving treatment landscape in SCLC Dror Limon, MD Barlessi Fabrice, MD PhD Sourasky Medical Center, Tel-Aviv, Israel Professor of Medicine, University of Aix Marseille Panel: Mor Moskovitz, MD and head of the Multidisciplinary Oncology and Rambam Medical Center, Haifa, Israel Therapeutic Innovations Department at Assistance Yosef Laviv, MD Publique Hôpitaux de Marseille, France Rabin Medical Center, Petach Tikva, Israel Supported by Roche Orit Kaidar-Person, MD 16:25-16:35 Value of Cancer Care Rambam Medical Center, Haifa, Israel Moderator: Katerina Shulman, MD 19:00 Dinner ISCORT Basket Committee Daniel Goldstein, MD Davidoff Center, Rabin Medical Center Petach Tikva, Israel 16:35-17:05 Keynote Lecture Moderator: Ben W. Corn Shaare Zedek Medical Center, Jerusalem, Israel Current thinking in the design of immuno- oncology and radiotherapy trials Adam P. Dicker, MD FASTRO Professor & Chair, Department of Radiation Oncology Director, Scholarly Inquiry Program in Digital Health & Data Science, Sidney Kimmel Medical College and Cancer Center, Philadelphia, USA Supported by ISCORT Ian Tannock, MD Thursday, January 10, 2019 Emeritus professor of Medical Oncology and Medical Biophysics, Princess Margaret Cancer 07:30-08:15 Meet the Professor Center and University of Toronto, Canada Breast Malignancies 08:20-08:40 Case Reports and Discussion Tarshish A Hall Moderator and Moderator: Bella Kaufman, MD Discusssant: Ruth Perets, MD PhD Sheba Medical Center, Ramat-Gan, Israel Rambam Medical Center, Haifa, Israel Karen A. Gelmon, MD Tumor lysis syndrome (TLS) in patient with Professor of Medicine at the University of British metastatic non-small cell lung carcinoma Columbia (mNSCLC) after a single dose of atezolizumab Medical Oncologist at the British Columbia Center Shira Sherman, MD Agency (BCCA), Canada Davidoff Center, Rabin Medical Center Supported by Astra Zeneca and MSD Petach Tikva, Israel Radiotherapy Photofrin II as a radiosensitizer in cervix cancer Fiesta Hall Noam Asna, MD Moderators: Aron Popovtzer, MD Barzilai Medical Center, Ashkelon, Israel Davidoff Center, Rabin Medical Center Gastro Intestinal Malignancies - General Session Petach Tikva, Israel 08:40-09:10 Keynote Lecture Raphael Yechieli, MD University of Miami and Sylvester Comprehensive Moderator: Nirit Yarom, MD Shamir (Asaf Harofe) Medical Cancer Center, USA Center, Tzrifin, Israel Adam Dicker, MD Understanding the pathway GI tumors Professor & Chair, Department of Radiation Dan Aderka, MD Sheba Medical Center Oncology Ramat-Gan, Israel Director, Scholarly Inquiry Program in Digital 09:10-09:45 Keynote Lecture Health & Data Science Moderator: Ephraim Idelevich, MD Kaplan Medical Center Sidney Kimmel Medical College and Cancer Rehovot, Israel Center, Philadelphia, PA, USA Present and future of systemic treatment of How to Read (and Write) a Paper, and Make a hepatocellular carcinoma Presentation Peter R. Galle, Univ-Prof Dr Tarshish B Hall Chairman - First Department of Internal Moderators: Alberto Gabizon, MD Medicine, University Medical Center Shaare Zedek Medical Center, Jerusalem, Israel Mainz, Germany Einav Gal Yam, MD PhD Supported by ISCORT Sheba Medical Center, Ramat-Gan, Israel 09:45-10:10 Tumor board - Advanced Hepatocellular 11:35-12:25 Original Abstracts: GI Malignancies Carcinoma Moderators: Sofia Man, MD Moderator: Ravit Geva, MD Soroka Medical Center, Beer Sheva, Israel Sourasky Medical Center, Tel-Aviv, Israel Ofer Purim, MD Panel: Peter R. Galle, Univ-Prof Dr Assuta Medical Center, , Israel Chairman - First Department of Internal Benefit of oxaliplatin in stage III colon cancer Medicine, University Medical Center according to IDEA risk groups – analysis of Mainz, Germany MOSAIC and C-07 trials Oren Shibolet, MD Ofer Margalit, MD Sourasky Medical Center, Tel-Aviv, Israel Sheba Medical Center, Ramat-Gan, Israel Allan-Isaac Bloom, MD Postoperative chemoradiotherapy in patients Hadassah Medical Center, Jerusalem, Israel with locally advanced gastric cancer with Supported by Roche and ISCORT poor pathologic response to neoadjuvant 10:10-10:40 Is There a Role for Surgery in Advanced GI chemotherapy Malignancies? Ron Lewin, MD Davidoff Center, Rabin Medical Center Moderator: Ayala Hubert, MD Hadassah Medical Center Petach Tikva, Israel Jerusalem, Israel Regorafenib treatment for patients with Pro: Izhak Avital, MD Soroka Medical Center hepatocellular carcinoma who progressed on Beer Sheva, Israel sorafenib - A cost-effectiveness analysis Con: Baruch Brenner, MD Davidoff Center Daniel Goldstein, MD Rabin Medical Center, Petach Tikva, Israel Davidoff Center, Rabin Medical Center 10:40-10:55 Coffee Break Petach Tikva, Israel 10:55-11:35 Tumor board – Gastro Intestinal Malignancies The role of genomic alterations as drivers of liver-specific metastasis formation in pancreatic Moderator: Irit Ben Aharon, MD PhD ductal adenocarcinoma (PDAC) cancer Rambam Medical Center, Haifa, Israel Ido Wolf, MD Panel: Talia Golan, MD Sourasky Medical Center, Tel-Aviv, Israel Sheba Medical Center, Ramat-Gan, Israel ATM as a biomarker for homologous Sharon Peles, MD recombination repair deficiency in pancreatic Sourasky Medical Center, Tel-Aviv, Israel ductal adenocarcinoma Eli Sapir, MD Tamar Beller, MD Assuta Medical Center, Ashdod, Israel Sheba Medical Center, Ramat-Gan, Israel Riad Haddad, MD Bnai Zion Medical Center 12:25-13:15 Lunch Haifa, Israel Supported by Eli Lilly Conference will reconvene at Tarshish Hall 1st Floor 14:35-15:15 Tumor Board: Breast Cancer Breast Cancer – General Session Moderator: Noa Efrat Ben-Baruch, MD 13:15-13:55 Keynote Lecture Kaplan Medical Center, Rehovot, Israel Moderator: Tamar Safra, MD Panel: Rinat Yerushalmi, MD Sourasky Medical Center, Tel-Aviv, Israel Davidoff Center, Rabin Medical Center Petach Tikva, Israel Finding our way through the pathways of breast cancer Tamar Peretz, MD Karen A. Gelmon, MD Hadassah Medical Center, Jerusalem, Israel Professor of Medicine at the University of British Bella Kaufman, MD Columbia Sheba Medical Center, Ramat-Gan, Israel Medical Oncologist at the British Columbia Center Amir Sonnenblick, MD Agency (BCCA), Canada Sourasky Medical Center, Tel-Aviv, Israel Supported by Astra Zeneca and MSD Dov Zippel, MD 13:55-14:25 Sponsored Lecture Sheba Medical Center, Ramat-Gan, Israel Moderator: Ekarerina Senatsky, MD Supported by Roche Lin Medical Center, Haifa, Israel 15:15-15:30 Coffee Break Update in treatment of advanced HR-positive 15:30-15:55 Sponsored Lecture HER2-negative breast cancer including position of CDK 4-6 Moderator: Ella Evron, MD Miguel Martin, MD PhD Kaplan Medical Center, Rehovot, Israel Professor of Medicine, Head Medical Oncology Small steps, big impact – Rethinking outcome Service, General Universitario Gregorio measures in high risk breast cancer Marañón, Universidad Complutense, Madrid Shani Paluch-Shimon, MD Spain Shaare Zedek Medical Center, Jerusalem, Israel Supported by Eli Lilly Supported by Roche 14:25-14:35 Value of Cancer Care 15:55- 16:20 Keynote Lecture Moderator: Rinat Yerushalmi, MD Moderator: Jamal Zidan, MD ISCORT Basket Committee Ziv Medical Center, , Israel Nathan Cherny, MD New horizons in clinical trials Shaare Zedek Medical Center, Jerusalem, Israel Ian Tannock, MD Emeritus professor of Medical Oncology and Medical Biophysics Princess Margaret Cancer Center and University of Toronto, Canada 16:20-17:10 Original Abstracts: Breast Malignancies Friday, January 11, 2019 Moderators: Beatrice Uziely, MD Hadassah Medical Center, Jerusalem, Israel Immune Oncology Larissa Rivo, MD Assuta Medical Center, Ashdod, Israel 08:30-10:05 Keynote lecture Partial compared to whole breast irradiation for Moderators: Michal Lotem, MD early stage breast cancer: A systematic review Hadassah Medical Center, Jerusalem, Israel and meta-analysis Gal Markel, MD PhD Yasmin Korzets Ceder, MD Sheba Medical Center, Ramat-Gan, Israel Davidoff Center, Rabin Medical Center 08:30-08:35 Introduction Petach Tikva, Israel Michal Lotem, MD Pregnancy after breast cancer diagnosis in Hadassah Medical Center, Jerusalem, Israel BRCA1\2 mutation carriers 08:35-09:05 Immune checkpoint inhibitors in melanoma and Albert Grinshpun, MD other cancers - a review Hadassah Medical Center, Jerusalem, Israel John Haanen The rate of the recurrent MSH6 mutations in Professor of Translational Immunotherapy of Ashkenazi Jewish breast cancer patients Cancer, Leiden University Medical Center Rinat Bernstein Molho, MD The Netherlands Sheba Medical Center, Ramat-Gan, Israel Supported by MSD Toxicity of extended adjuvant aromatase 09:05-09:35 Tumor neo-antigens and T cell recognition inhibitors therapy in postmenopausal breast Yardena Samuels cancer patients: A systematic review and meta- Director, the EKARD Institute for Cancer Diagnosis analysis Research, Department of Molecular Cell Biology, Hadar Goldvaser, MD The Weizmann Institute of Science Davidoff Center, Rabin Medical Center Rehovot, Israel Petach Tikva, Israel 09:35-10:05 Immunotherapy beyond melanoma Is prophylactic breast surgery indicated in BRCA Dmitriy Zamarin, MD mutation carriers following diagnosis of ovarian Gynecologic Medical Oncology, cancer? Immunotherapeutics, Memorial Sloan-Kettering Barliz Waissengrin, MD Cancer Center, New York, USA Sourasky Medical Center, Tel-Aviv, Israel Supported by ISCORT 19:00 Dinner 10:05-10:45 Sponsored Lecture 11:50-12:30 Proposals and Follow-Up From Previous Years Moderator: Alexander Yaacobson, MD Grants Reports Soroka Medical Center, Beer Sheva, Israel Moderators: Valeria Semenisty, MD New approaches in the treatment of local and Rambam Medical Center, Haifa, Israel advanced melanoma Michal Lotem, MD Jacob Schachter, MD Hadassah Medical Center, Jerusalem, Israel Sheba Medical Center, Ramat-Gan, Israel Proposals: Michal Lotem, MD Liquid biopsy of tumor microbiome Hadassah Medical Center, Jerusalem, Israel Albert Grinshpun, MD Supported by BMS Hadassah Medical Center, Jerusalem, Israel 10:45-11:00 Coffee Break Interleukin-13 Receptor α1: A novel molecular 11:00-11:30 Tumor Board: Melanoma target to prevent radiation induced heart disease Uri Amit, MD Moderator: Ronni Shapira, MD Sheba Medical Center, Ramat-Gan, Israel Sheba Medical Center, Ramat-Gan, Israel Follow-Up: Panel: Gil Bar-Sela, MD Attitudes of oncologic patients towards Haemek Medical Center, Afula, Israel participation in clinical trials Ronnen Brenner, MD Nethanel Asher, MD Wolfson Medical Center, , Israel Sheba Medical Center, Ramat-Gan, Israel Olga Vornicova, MD Minimally invasive screening approach for early Rambam Medical Center, Haifa, Israel detection of ovarian cancer Dov Zipel, MD Keren Levanon, MD PhD Sheba Medical Center, Ramat-Gan, Israel Sheba Medical Center, Ramat-Gan, Israel Supported by NOVARTIS 12:30 Closing Remarks 11:30-11:50 Sponsored Lecture 12:45 Lunch Moderator: David Sarid, MD 13:30-14:30 ISCORT Forum Meeting Sourasky Medical Center, Tel-Aviv, Israel Are we ready to offer a truly pan-tumor approach to therapy? Ido Wolf, MD Sourasky Medical Center, Tel-Aviv, Israel Supported by Roche Radiation Oncology Program 08:30-09:50 Clinical Abstracts Moderators: Eliahu Gez, MD Wednesday, January 9, 2019 Ziv Medical Center, Safed, Israel Eli Sapir, MD 16:35-17:05 Keynote Lecture Assuta Medical Center, Ashdod, Israel Lecture would be held in the main conference hall Adaptive IMRT planning improves pharyngeal Moderator: Ben W. Corn, MD constrictor sparing for oropharyngeal cancer Shaare Zedek, Medical Center, Jerusalem, Israel Dror Limon, MD Current thinking in the design of immuno- Sourasky Medical Center, Tel-Aviv, Israel oncology and radiotherapy trials CPAP improves the anatomy and dosimetry Adam P. Dicker, MD FASTRO of patients undergoing breath-hold motion Professor & Chair, Department of Radiation management for thoracic SBRT Oncology Igor Sadetskii, MD Director, Scholarly Inquiry Program in Digital Sheba Medical Center, Ramat-Gan, Israel Health & Data Science, Sidney Kimmel Medical Modern radiotherapy with or without androgen College and Cancer Center, Philadelphia, PA, USA deprivation therapy in intermediate-risk prostate Supported by ISCORT cancer Uri Amit, MD Sheba Medical Center, Ramat-Gan, Israel Thursday, January 10, 2019 Gastric fundus irradiation does not increase risk of postoperative anastomotic leakage in 07:30-08:15 Meet the Professor esophageal cancer Fiesta Hall Noga Kurman, MD Radiotherapy Davidoff Center, Rabin Medical Center Moderators: Aron Popovtzer, MD Petach Tikva, Israel Davidoff Center, Rabin Medical Center Adjuvant irradiation sandwiched between 6 Petach Tikva, Israel cycles of carboplatin and paclitaxel for FIGO Raphael Yechieli, MD stage III endometrial adenocarcinoma University of Miami and Sylvester Comprehensive Nicola Nasser, MD PhD Cancer Center Florida, USA Montefiore Medical Center, Albert Einstein College of Medicine, New York, USA Adam Dicker, MD Professor & Chair, Department of Radiation The outcome of concomitant chemoradiotherapy Oncology for the treatment of nasopharyngeal carcinoma Director, Scholarly Inquiry Program in Digital in the elderly population Health & Data Science Orly Yariv, MD Sidney Kimmel Medical College and Cancer Davidoff Center, Rabin Medical Center Center Petach Tikva, Israel Philadelphia, PA, USA The effect of surgery to radiation interval on 12:05-12:30 Sponsored Lecture loco-regional recurrence and survival in patients The Elekta unity MR Linac – An overview and receiving post-mastectomy radiation treatments update of clinical experience Adaya Rosenthal, MD Joel W. Goldwein, MD Sheba Medical Center, Ramat-Gan, Israel Senior Vice President and Director, Medical Affairs 09:55-10:30 Physics Abstracts Elekta, Philadelphia, PA, USA Moderator: Rachel Bar Deroma, PhD Supported by Medtechnika Rambam Medical Center, Haifa, Israel 12:30-13:15 Lunch Development of X-ray lens for low energy 13:30-14:15 Clinical Debate: Oligometastatic Disease Turns 25 radiotherapy & radiosurgery Moderator: Adam P. Dicker, MD FASTRO Dror Alezra, PhD Professor & Chair, Department of Radiation Sheba Medical Center, Ramat-Gan, Israel Oncology Do it, fuse it or lose it: On the benefits of PET CT Director, Scholarly Inquiry Program in Digital simulation Health & Data Science, Sidney Kimmel Medical Alona Rosenbaum, PhD College and Cancer Center, Philadelphia, PA, USA Ziv Medical Center, Safed, Israel Amichay Meirowitz, MD SRS spine plans: Comparing elements & eclipse Hadassah Medical Center, Jerusalem, Israel simulations to real measures Tomer Charas, MD Noam Weizman, MSc Rambam Medical Center, Haifa, Israel Hadassah Medical Center, Jerusalem, Israel 14:30-15:15 Revisiting the Conventional Wisdom in Non-Small 10:40-10:55 Coffee Break Cell Lung Cancer 10:55-11:20 Sponsored Lecture Moderator: Orit Kaidar-Person, MD Moderator: Raphael Pfeffer, MD Rambam Medical Center, Haifa, Israel Assuta Medical Center, Tel-Aviv, Israel Differential radiosensitivity between the lung Daphne Levin, PhD primary and the mediastinum Assuta Medical Center, Tel-Aviv, Israel Slava Soyfer, MD Real time image-guided RT: From 2D to 4D. Will Sourasky Medical Center, Tel-Aviv, Israel the MR Linac change practice? Technological advances in the treatment of lung Supported by Assuta Medical Center cancer 11:20-12:05 Sponsored Lecture Sarit Appel, MD Sheba Medical Center, Ramat-Gan, Israel Proton therapy: Benefits of IMPT Zelig Tochner, MD Integrating radiotherapy with novel biologic & Professor of Radiation Oncology, University of immunotherapeutic agents Pennsylvania, PA, USA Aaron Allen, MD Supported by VARIAN Davidoff Center, Rabin Medical Center Petach Tikva, Israel 15:15-15:30 Coffee Break 17:30-18:15 Roundtable Discussion 15:45-16:15 Keynote Lecture NRG & ISROG: Re-Kindling the Flames of Introduction: Zvi Symon, MD Research? Sheba Medical Center, Ramat-Gan, Israel Moderator: Aaron Allen, MD Teen horror: The radiation oncologist meets the Rabin Medical Center, Petach Tikva, Israel AYA population Panel: Rachamim Ben-Yosef MD Raphael Yechieli, MD Rambam Medical Center, Haifa, Israel Associate Professor of Radiation Oncology, Yaacov Lawrence, MD University of Miami and Sylvester Comprehensive Sheba Medical Center, Ramat-Gan, Israel Cancer Center, Miami, FL, USA Adam Dicker, MD 16:30-17:00 Sponsored Lecture Professor & Chair, Department of Radiation Moderator: Maoz Ben Ayun, PhD Oncology Chaim Sheba Medical Center, Ramat-Gan, Israel Director, Scholarly Inquiry Program in Digital ExacTrac Dynamic – A new dimension in surface Health & Data Science, Sidney Kimmel Medical tracking College and Cancer Center, Philadelphia, PA, USA Luisa Schuetzenmeister, MSc Shalom Kalinicki, MD Product Manager ExacTrac Professor of Radiation Oncology, Albert Einstein BRAINLAB, Munich, Germany College of Medicine Supported by BRAINLAB Chairman, Department of Radiation Oncology 17:00-17:25 Sponsored Lecture Montefiore Medical Center New York, USA Proton therapy: A perspective on the future Nicolas Denef, MSc Product Manager, IBA Louvain-La-Neuve, Belgium

This programm was printed with the support of Roche Pharmaceuticals (Israel) Ltd.