Anomalous Origin of One Pulmonary Artery Branch from the Ascending Aorta: Experience of Our Center

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Türk Kardiyol Dern Arş - Arch Turk Soc Cardiol 2010;38(6):411-415 411 Anomalous origin of one pulmonary artery branch from the ascending aorta: experience of our center Çıkan aorttan köken alan anormal pulmoner arter dalı: Merkezimizin deneyimi Abdullah Erdem, M.D., Numan Ali Aydemir, M.D.,# Halil Demir, M.D., Cenap Zeybek, M.D., Türkay Sarıtaş, M.D., Celal Akdeniz, M.D., Ali Rıza Karacı, M.D.,# Ahmet Çelebi, M.D. Departments of Pediatric Cardiology and #Cardiovascular Surgery, Siyami Ersek Cardiovascular Surgery Center, İstanbul Objectives: Anomalous origin of one pulmonary artery Amaç: Aortik ve pulmoner kapakların ayrı ayrı varlığında, branch from the aorta in the presence of separate aortic bir pulmoner arter dalının çıkan aorttan köken alması nadir and pulmonary valves is a rare but important entity ne- rastlanan bir anomalidir ve geri dönüşsüz pulmoner vas- cessitating early diagnosis and surgery to prevent irre- küler hastalık gelişiminin engellenmesi için erken tanı ve versible vascular pulmonary disease. We evaluated our cerrahi tamir gerektirir. Bu çalışmada bu nadir patolojinin experience with seven infants having this anomaly. görüldüğü yedi bebekle ilgili deneyimimiz değerlendirildi. Study design: Between December 2003 and 2009, a Çalışma planı: Aralık 2003 ile 2009 tarihleri arasındaki total of seven infants (2 girls, 5 boys, age range 4 days dönemde yedi hastada (2 kız, 5 erkek; yaş aralığı 4-84 to 84 days) were diagnosed as having anomalous origin gün) pulmoner arter dalının çıkan aorttan köken aldığı of one pulmonary artery branch from the aorta. Clini- anomali tanısı kondu. Hastane kayıtlarından olguların cal records were reviewed for clinical features, operative klinik özellikleri, cerrahi işlemleri ve takip sonuçları in- procedures, and postoperative follow-up. celendi. Results: Common symptoms were dyspnea, tachypnea, Bulgular: Hastaların ortak başvuru semptomları nefes and poor feeding. All the cases were diagnosed by echo- darlığı, hızlı soluma ve beslenme zorluğuydu. Tüm ol- cardiography. The right pulmonary artery in six cases and gularda tanı ekokardiyografi ile kondu. Altı hastada sağ the left pulmonary artery in one case originated from the pulmoner arter, bir hastada sol pulmoner arter çıkan aort- ascending aorta. In addition, three patients had patent tan köken almaktaydı. Eşlik eden anomaliler üç hastada ductus arteriosus (PDA), five patients had patent foramen duktus arteriyozus açıklığı, beş hastada foramen ovale ovale, and one patient had interruption of the aortic arch açıklığı, bir hastada aortik ark kesintisi ve aortopulmoner and aortopulmonary window. All patients underwent sur- pencere idi. Tüm hastalarda cerrahi olarak anormal pul- gical re-implantation of the anomalous pulmonary artery moner arter pulmoner gövdeye taşındı. Ayrıca, üç has- branch to the pulmonary trunk. Associated surgical pro- tada duktus arteriyozus açıklığı bağlandı ve bir hastada cedures included PDA ligation in three patients, and total aortik ark kesintisi ve aortopulmoner pencere onarımı ya- repair of interrupted aortic arch and aortopulmonary win- pıldı. Hiçbir olguda hastaneiçi ölüm görülmedi. İki hasta- dow in one patient. There were no in-hospital deaths. Two da entübasyon süresi uzadı (10 ve 16 gün). Tüm hastalar patients had prolonged intubation (10 and 16 days). All pa- iyi durumda hastaneden taburcu edildi. Olguların iki ay tients were discharged in good clinical condition. During a ile altı yıl arasında değişen izlem süreleri içinde, sadece follow-up period ranging from two months to six years, only bir hastada anastomoz bölgesinde hafif derecede darlık one patient developed stenosis at the site of anastomosis. gelişti. Conclusion: Prompt diagnosis at infancy, improved sur- Sonuç: Bebeklik döneminde erken tanı, zamanında cer- gical technique, and good patient care decrease mortal- rahi girişim ve ameliyat sürecinde iyi bakım, pulmoner ity and morbidity associated with anomalous origin of arter dalının çıkan aorttan köken almasına bağlı morbi- the pulmonary artery from the aorta. dite ve mortaliteyi azaltmaktadır. Key words: Echocardiography; heart defects, congenital/sur- Anah tar söz cük ler: Ekokardiyografi; kalp defekti, doğuştan/ gery; infant, newborn; pulmonary artery/abnormalities/surgery. cerrahi; bebek, yenidoğan; pulmoner arter/anormallik/cerrahi. Received: January 23, 2010 Accepted: March 24, 2010 Correspondence: Dr. Abdullah Erdem. Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, 34668 İstanbul, Turkey. Tel: +90 216 - 349 91 20 / 4604 e-mail: [email protected] 412 Türk Kardiyol Dern Arş Anomalous origin of one pulmonary artery branch pulmonary artery in one patient. In all cases, the other from the ascending aorta (hemitruncus) is a rare con- pulmonary artery was in continuity with the main pul- genital heart disease, in which one of the pulmonary monary artery originating from the right ventricle. All artery branches arises from the ascending aorta in the the patients had evidence for pulmonary hypertension presence of separate aortic and pulmonary valves.[1,2] detected by echocardiography. Associated anomalies The pathology is frequently associated with other included patent ductus arteriosus (PDA) in three pa- cardiac malformations and rarely presents as an iso- tients, patent foramen ovale in five patients, and inter- lated anomaly.[2-4] The condition is included in the ruption of the aortic arch and aortopulmonary win- group of aortic arch abnormalities and is caused by dow in one patient. partial or complete developmental failure of the left [5] Operative technique was direct implantation of the sixth arch. abnormal pulmonary artery branch to the main pul- Hemitruncus results in a large left-to-right shunt monary artery in all the patients. The anomalous pul- with the entire cardiac output from the right ventricle monary artery was cut from its origin at the ascend- going to one lung while the other lung receives blood ing aorta and anastomosed to the lateral aspect of the at systemic pressure from the aorta. Thus, the pulmo- main pulmonary artery in end-to-side fashion (Fig. 2). nary vascular bed of both lungs may be vulnerable to The defect in the aorta was directly sutured. A median the development of pulmonary vascular obstructive sternotomy was preferred in all the cases. Associated disease. Without surgery, one-year survival has been surgical procedures included PDA ligation in three pa- reported to be very low.[6] Early operation with good tients, and total repair of interrupted aortic arch and preoperative and postoperative care results in excel- aortopulmonary window in one patient. There was no lent survival.[7-9] intraoperative mortality. Two cases were extubated We evaluated surgical results of hemitruncus with within 48 hours. Two patients developed early post- separate aortic and pulmonary valves in seven infants operative pulmonary hypertensive crisis that required with an emphasis on diagnostic evaluation. prolonged ventilation (10 and 16 days) with the use of inhaled prostacyclin. PATIENTS AND METHODS During a follow-up period ranging from two Between December 2003 and December 2009, a total months to six years, none of the patients developed of seven patients were diagnosed as having hemitrun- significant stenosis at the anastomosis line except one cus in normally connected hearts with two separate patient with mild stenosis. Periodical echocardio- semilunar valves. Patients with a common arterial graphic examination was suggested for this patient for trunk with nonconfluent pulmonary arteries were ex- a pulse wave gradient of 25 mmHg at the anastomosis cluded from the study. Clinical records were reviewed site. to document clinical features, operative procedures, In one patient, a complex surgical procedure and postoperative follow-up. Informed consent was was performed in the same session, consisting of obtained from the parents before operation, approval re-implantation of the right pulmonary artery to the was obtained from the local ethics committee and hos- main pulmonary artery, reconstruction surgery for pital administration to review the files retrospectively. type A interruption, closure of the aortopulmonary RESULTS window, and PDA ligation. After a prolonged intu- bation period with several pulmonary hypertensive Of seven patients, five patients were males, two pa- crises, the patient was discharged from hospital on the tients were females. At the time of diagnosis, the 43rd postoperative day. age of the patients ranged from 4 to 84 days, and the weight from 3 to 4.8 kg. Common symptoms at pre- DISCUSSION sentation were dyspnea, tachypnea, and poor feeding. Anomalous origin of one pulmonary artery branch One patient presented with transient cyanosis because from the ascending aorta is an extremely rare of a lung infection. conotruncal malformation accounting for only 0.12% All the cases were diagnosed by echocardiography of all congenital heart diseases.[2,4,5] The disease was and only two patients underwent catheter-angiography first described by Fraentzel in 1868.[10] Since then, for evaluation of cardiac morphology and associated there have been several case reports and case series. anomalies (Fig. 1). The anomalous branch was the Anomalous origin of the right pulmonary artery is 5 right pulmonary artery in six patients, and the left to 6 times more frequent than the left.[2,4,5] In our se- Anomalous origin of one pulmonary artery branch from the ascending aorta: experience of our center 413
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