A New Drug-Shelf Arrangement for Reducing Medication Errors Using Data Mining: a Case Study
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Side Effects of Labor Market Policies
DISCUSSION PAPER SERIES IZA DP No. 13846 Side Effects of Labor Market Policies Marco Caliendo Robert Mahlstedt Gerard J. van den Berg Johan Vikström NOVEMBER 2020 DISCUSSION PAPER SERIES IZA DP No. 13846 Side Effects of Labor Market Policies Marco Caliendo University of Potsdam, IZA, DIW and IAB Robert Mahlstedt University of Copenhagen and IZA Gerard J. van den Berg University of Bristol, University of Groningen, IFAU, IZA, ZEW, CEPR, CESifo and UCLS Johan Vikström IFAU, Uppsala University and UCLS NOVEMBER 2020 Any opinions expressed in this paper are those of the author(s) and not those of IZA. Research published in this series may include views on policy, but IZA takes no institutional policy positions. The IZA research network is committed to the IZA Guiding Principles of Research Integrity. The IZA Institute of Labor Economics is an independent economic research institute that conducts research in labor economics and offers evidence-based policy advice on labor market issues. Supported by the Deutsche Post Foundation, IZA runs the world’s largest network of economists, whose research aims to provide answers to the global labor market challenges of our time. Our key objective is to build bridges between academic research, policymakers and society. IZA Discussion Papers often represent preliminary work and are circulated to encourage discussion. Citation of such a paper should account for its provisional character. A revised version may be available directly from the author. ISSN: 2365-9793 IZA – Institute of Labor Economics Schaumburg-Lippe-Straße 5–9 Phone: +49-228-3894-0 53113 Bonn, Germany Email: [email protected] www.iza.org IZA DP No. -
Department of Economics
DEPARTMENT OF ECONOMICS JOHANNES KEPLER UNIVERSITY OF LINZ Birth Order, Parental Health Investment, and Health in Childhood by Gerald J. Pruckner Nicole Schneeweis Thomas Schober Martina Zweimüller Working Paper No. 1916 August 2019 Johannes Kepler University of Linz Department of Economics Altenberger Strasse 69 A-4040 Linz - Auhof, Austria www.econ.jku.at [email protected] Birth Order, Parental Health Investment, and Health in Childhood∗ Gerald J. Prucknera,b, Nicole Schneeweisa,c,d, Thomas Schobera,b, Martina Zweimuller¨ a aJohannes Kepler University Linz, Austria bChristian Doppler Laboratory for Aging, Health, and the Labor Market, Austria cIZA, Institute for the Study of Labor, Bonn, Germany dCEPR, Centre for Economic Policy Research, London August 9, 2019 Abstract Research has shown that cognitive and non-cognitive skills, education and earn- ings decrease with birth order. Less is known about birth order effects on health. This paper provides a comprehensive analysis of the relationship between birth or- der, health at birth and in childhood, and parental health investment. High-quality administrative data on children born in Austria between 1984 and 2015 allow us to exploit within-family variation in birth order to account for confounding family- level factors. In a sample of families with two to four children, we find statistically significant and quantitatively important birth order effects on health at birth and in primary school. These birth order effects are positive, in that later-born siblings are healthier than the first-born child, and increase with birth order. Consequently, first-born children are more likely to consume medical drugs and to utilize inpatient and outpatient medical services. -
Nature, Frequency and Determinants of Prescription Modifications in Dutch
Nature, frequency and determinants of prescription modi®cations in Dutch community pharmacies Henk Buurma,1,3 Peter A. G. M. de Smet,2,5 Olga P. van den Hoff2 & Antoine C. G. Egberts3,4 1SIR Institute for Pharmacy Practice Research, Leiden, 2WINAp (Scienti®c Institute Dutch Pharmacists), The Hague, 3Department of Pharmacoepidemiology and Pharmacotherapy, Faculty of Pharmacy, University of Utrecht, 4Hospital pharmacy `Midden-Brabant', TweeSteden Hospital and St Elisabeth Hospital, Tilburg and 5Department of Clinical Pharmacy, University Hospital Nijmegen, The Netherlands Aims To examine the nature, frequency and determinants of prescription modi®cations in Dutch community pharmacies. Methods A prospective case-control study comparing modi®ed prescriptions with nonmodi®ed prescriptions was carried out in 141 Dutch community pharmacies. 2014 modi®ed prescriptions (cases), collected in the selected pharmacies on a predetermined day in a speci®c period (25th February until 12th March 1999) and 2581 nonmodi®ed prescriptions (controls) randomly selected on the same day were studied. The nature and frequency of prescription modi®cations and patient, drug and prescriber related determinants for a modi®ed prescription were assessed. Results The overall incidence of prescription modi®cations was 4.3%, with a mean of 14.3 modi®cations per pharmacy per day. For prescription only medicines (POM) the incidence was 4.9%. The majority of POM modi®cations concerned a clari®cation (71.8%). In 22.2% a prescription could potentially have had clinical consequences when not altered; in more than half of the latter it concerned a dose error (13.7% of all cases). POM prescriptions of patients of 40±65 years had a signi®cantly lower chance of modi®cation compared with those of younger people (OR=0.74 [0.64±0.86]). -
Common SUMMARY of PRODUCT CHARACTERISTICS for Fucidin® H
Common SUMMARY OF PRODUCT CHARACTERISTICS for Fucidin® H cream MRP: DK/H/0130/001 1 1. NAME OF THE MEDICINAL PRODUCT Fucidin H, 20 mg/g + 10 mg/g Cream 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Fusidic acid 20 mg/g and hydrocortisone acetate 10 mg/g. Excipients with known effect Butyl hydroxyanisole E320 (40 microgram/g), cetyl alcohol (111 mg/g) and potassium sorbate E202 (2.7 mg/g). For the full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM Cream White water-miscible cream 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Treatment of infected atopic dermatitis. 4.2 Posology and method of administration Adults and paediatric population: Fucidin H cream should be applied to the affected area of the skin 3 times daily, for max. 2 weeks. 4.3 Contraindications Hypersensitivity to the active substances or to any of the excipients listed in section 6.1. Due to the content of corticosteroid, Fucidin H is contraindicated in the following conditions: Primary skin infections caused by fungi, virus or bacteria, either untreated or uncontrolled by appropriate treatment (see section 4.4). Skin manifestations in relation to tuberculosis, either untreated or uncontrolled by appropriate therapy. Perioral dermatitis and rosacea. 4.4 Special warnings and precautions for use Long-term continuous topical therapy with Fucidin H should be avoided. Depending on the application site, possible systemic absorption of hydrocortisone acetate should always be considered during treatment with Fucidin H. 2 Due to the content of corticosteroid, Fucidin H should be used with care near the eyes. Avoid getting Fucidin H into the eyes (see section 4.8). -
R&D Briefing 76
The Impact of Recent Regulatory Developments on the Mexican Therapeutic Landscape Access to innovative medicines is key to El acceso a medicamentos innovadores es clave para improving overall population health, reducing mejorar la salud de toda la población, para reducir los hospitalisation time and decreasing morbidity and tiempos de hospitalización, la morbilidad y la mortalidad mortality. An efficient regulatory process can be de un país. Un proceso regulatorio eficiente tiene un reflected in measurable positive health impacts; impacto positivo medible en la salud, y por el contrario, conversely, activities that slow or impede acciones que retrasan o impiden la eficiencia regulatoria y regulatory efficiency and predictability can be su predictibilidad pueden ser perjudiciales. La parálisis detrimental. Recent developments in the Mexican reciente del Sistema regulatorio mexicano respecto a la regulatory system for the assessments of evaluación de nuevos medicamentos innovadores innovative new products have had a negative conlleva un impacto negativo en la salud de la población impact on Mexican public health. mexicana. This Briefing addresses the impact of suspending Este informe analiza el impacto de la suspensión de las the activities of the New Molecules Committee actividades del Comité de Moléculas Nuevas (NMC, por (NMC) on the Mexican therapeutic landscape. sus siglas en inglés) sobre el horizonte terapéutico de First, we compared the way that “new medicines” México. En primer lugar, comparamos la definición de are defined within the context of the Mexican nuevos medicamentos según el contexto regulatorio regulatory system, with definitions used by mexicano con las definiciones adoptadas por otras comparable regulators and health organisations. agencias reguladoras u organizaciones de salud del We have also investigated the extent to which mundo. -
Summary of Product Characteristics
SUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE MEDICINAL PRODUCT *IPERTEN/ARTEDIL/MANYPER 10mg tablets IPERTEN/ARTEDIL/MANYPER 20mg tablets 2. QUALITATIVE AND QUANTITATIVE COMPOSITION IPERTEN/ARTEDIL/MANYPER 10 mg tablets Each tablet contains: Manidipine hydrochloride 10mg Excipient with known effect: 119,61 mg lactose monohydrate/tablet IPERTEN/ARTEDIL/MANYPER 20 mg tablets Each tablet contains: Manidipine hydrochloride 20mg Excipient with known effect: 131,80 mg lactose monohydrate/tablet For the full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM Tablet IPERTEN/ARTEDIL/MANYPER 10mg: pale yellow, round, scored tablet; IPERTEN/ARTEDIL/MANYPER 20mg: yellow-orange, oblong, scored tablet. 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Mild to moderate essential hypertension 4.2 Posology and method of administration The recommended starting dose is 10 mg once a day. Should the antihypertensive effect be still insufficient after 2-4 weeks of treatment, it is advisable to increase the dosage to the usual maintenance dose of 20 mg once a day. Elderly In view of the slowing down of metabolism in the elderly, the recommended dose is 10mg once daily. This dosage is sufficient in most elderly patients; the risk/benefit of any dose increase should be considered with caution on an individual basis. Renal impairment In patients with mild to moderate renal dysfunction care should be taken when increasing the dosage from 10 to 20mg once a day. Hepatic impairment Due to the extensive hepatic metabolisation of manidipine, patients with mild hepatic dysfunction should not exceed 10mg once a day (see also Section 4.3 Contraindications). Tablet must be swallowed in the morning after breakfast, without chewing it, with a few liquid. -
Renal Clinical Pharmacy Services“
DISSERTATION „Renal clinical pharmacy services“ Mag.pharm. Gunar Stemer angestrebter akademischer Grad Doktor der Naturwissenschaften (Dr.rer.nat.) Wien, 2011 Studienkennzahl lt. Studienblatt: A 091 449 Dissertationsgebiet lt. Studien- Pharmazie blatt: Betreuerin / Betreuer: Ao. Univ. Prof. Mag. Dr. Rosa Lemmens 2 e pensando di lei mi sopragiunse uno soave sonno ego dominus tuus vide cor tuum e d’esto core ardendo cor tuum lei paventosa umilmente pascea appreso gir io ne vedea piangendo la letizia si convertia in amarissimo pianto io sono in pace cor meum io sono in pace vide cor meum Dante Alighieri La Vita Nuova ~1293 Gewidmet meinen Eltern Annelies und Franz, in aufrichtiger Dankbarkeit und Liebe Dedicated to my parents Annelies and Franz, in sincere gratitude and love 3 4 ACKNOWLEDGEMENTS This thesis would not have been possible without the continuous support, help, and contributions of so many colleagues, companions, friends, and beloved family members. First, I want to express my deepest gratitude to my doctoral advisor, Mrs. Prof. Rosa Lemmens, for her commitment in supervising my thesis work, her support during the writing of this thesis, several constructive discussions with her, and her critical comments. My sincerest thanks are extended to the head of the pharmacy department of the Vienna General Hospital, Mrs. SR Mag. Elfriede Dolinar, for providing me with this unique opportunity to work on the topic of clinical pharmacy and, thus, contribute to the evolution of the complete hospital pharmacy and clinical pharmacy discipline in Austria. I would like to thank her for her trust in my capabilities to succeed in this demanding project over the last three years by implementing new services, her vision regarding the discipline of hospital pharmacy, her overall contribution to the development of the profession of hospital pharmacy, and her continuous belief in the value of clinical pharmacy services. -
A Side Effect Resource to Capture Phenotypic Effects of Drugs
Molecular Systems Biology 6; Article number 343; doi:10.1038/msb.2009.98 Citation: Molecular Systems Biology 6:343 & 2010 EMBO and Macmillan Publishers Limited All rights reserved 1744-4292/10 www.molecularsystemsbiology.com REPORT A side effect resource to capture phenotypic effects of drugs Michael Kuhn1,4, Monica Campillos1, Ivica Letunic1, Lars Juhl Jensen1,2 and Peer Bork1,3,* 1 Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 2 Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark and 3 Max-Delbru¨ck-Centre for Molecular Medicine, Berlin, Germany 4 Present address: Biotechnology Center, TU Dresden, 01062 Dresden, Germany * Corresponding author. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany. Tel.: þ 49 6221 387 8526; Fax: þ 49 6221 387 517; E-mail: [email protected] Received 9.7.09; accepted 30.11.09 The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug–side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. -
The Repurposing Drugs in Oncology Database
ReDO_DB: the repurposing drugs in oncology database Pan Pantziarka1,2, Ciska Verbaanderd1,3, Vidula Sukhatme4, Rica Capistrano I1, Sergio Crispino1, Bishal Gyawali1,5, Ilse Rooman1,6, An MT Van Nuffel1, Lydie Meheus1, Vikas P Sukhatme4,7 and Gauthier Bouche1 1The Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium 2The George Pantziarka TP53 Trust, London, UK 3Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium 4GlobalCures Inc., Newton, MA 02459 USA 5Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 USA 6Oncology Research Centre, Vrije Universiteit Brussel, Brussels, Belgium 7Emory University School of Medicine, Atlanta, GA 30322 USA Correspondence to: Pan Pantziarka. Email: [email protected] Abstract Repurposing is a drug development strategy that seeks to use existing medications for new indications. In oncology, there is an increased level of activity looking at the use of non-cancer drugs as possible cancer treatments. The Repurposing Drugs in Oncology (ReDO) project has used a literature-based approach to identify licensed non-cancer drugs with published evidence of anticancer activity. Data from 268 drugs have been included in a database (ReDO_DB) developed by the ReDO project. Summary results are outlined and an assessment Research of clinical trial activity also described. The database has been made available as an online open-access resource (http://www.redo-project. org/db/). Keywords: drug repurposing, repositioning, ReDO project, cancer drugs, online database Published: 06/12/2018 Received: 27/09/2018 ecancer 2018, 12:886 https://doi.org/10.3332/ecancer.2018.886 Copyright: © the authors; licensee ecancermedicalscience. -
Rapport 2008
rapport 2008 Reseptregisteret 2004-2007 The Norwegian Prescription Database 2004-2007 Marit Rønning Christian Lie Berg Kari Furu Irene Litleskare Solveig Sakshaug Hanne Strøm Rapport 2008 Nasjonalt folkehelseinstitutt/ The Norwegian Institute of Public Health Tittel/Title: Reseptregisteret 2004-2007 The Norwegian Prescription Database 2004-2007 Redaktør/Editor: Marit Rønning Forfattere/Authors: Christian Lie Berg Kari Furu Irene Litleskare Marit Rønning Solveig Sakshaug Hanne Strøm Publisert av/Published by: Nasjonalt folkehelseinstitutt Postboks 4404 Nydalen NO-0403 Norway Tel: + 47 21 07 70 00 E-mail: [email protected] www.fhi.no Design: Per Kristian Svendsen Layout: Grete Søimer Acknowledgement: Julie D.W. Johansen (English version) Forsideillustrasjon/Front page illustration: Colourbox.com Trykk/Print: Nordberg Trykk AS Opplag/ Number printed: 1200 Bestilling/Order: [email protected] Fax: +47-21 07 81 05 Tel: +47-21 07 82 00 ISSN: 0332-6535 ISBN: 978-82-8082-252-9 trykt utgave/printed version ISBN: 978-82-8082-253-6 elektronisk utgave/electronic version 2 Rapport 2008 • Folkehelseinstituttet Forord Bruken av legemidler i befolkningen er økende. En viktig målsetting for norsk legemiddelpolitikk er rasjonell legemiddelbruk. En forutsetning for arbeidet med å optimalisere legemiddelbruken i befolkningen er kunnskap om hvilke legemidler som brukes, hvem som bruker legemidlene og hvordan de brukes. For å få bedre kunnskap på dette området, vedtok Stortinget i desember 2002 å etablere et nasjonalt reseptbasert legemiddelregister (Reseptregisteret). Oppgaven med å etablere registeret ble gitt til Folkehelseinstituttet som fra 1. januar 2004 har mottatt månedlige opplysninger fra alle apotek om utlevering av legemidler til pasienter, leger og institusjoner. Denne rapporten er første utgave i en planlagt årlig statistikk fra Reseptregisteret. -
New Zealand Data Sheet 1 Avaxim Suspension for Injection 2 Qualitative and Quantitative Composition 3 Pharmaceutical Form 4 Clin
NEW ZEALAND DATA SHEET 1 AVAXIM SUSPENSION FOR INJECTION Hepatitis A virus (inactivated, adsorbed) 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Avaxim is a sterile suspension for injection containing formaldehyde-inactivated hepatitis A virus (GBM strain) adsorbed onto aluminium hydroxide. Each 0.5mL dose contains: Active ingredient: Hepatitis A virus* ………………………………………………160 antigen units** * GBM strain cultured on MRC-5 human diploid cells. MRC-5 is a cell line that was derived from human embryonic lung tissue in the 1960s. ** In the absence of an international standardised reference, the antigen content is expressed using an in-house reference. The manufacture of this product includes exposure to bovine derived materials. No evidence exists that any case of vCJD (considered to be the human form of bovine spongiform encephalopathy) has resulted from the administration of any vaccine product. Contains phenylalanine and residual neomycin. For the full list of excipients, see Section 6.1 List of excipients. 3 PHARMACEUTICAL FORM Suspension for injection Avaxim is a cloudy, whitish suspension. 4 CLINICAL PARTICULARS 4.1 THERAPEUTIC INDICATIONS Avaxim is indicated for active immunisation against hepatitis A infection in adults and children 2 years and over. Vaccination against viral hepatitis A is recommended for individuals who are or will be at increased risk of infection: • travellers to areas of moderate or high endemicity for hepatitis A Property of the Sanofi group - strictly confidential ava-ccdsv10-dsv5-24may21 Page 1 • visitors to rural and remote indigenous communities • child day-care and pre-school personnel • the intellectually disabled and their carers • health care providers • sewerage workers • men who have sex with men • injecting drug users • patients with chronic liver disease • haemophiliacs who may receive pooled plasma concentrates 4.2 DOSE AND METHOD OF ADMINISTRATION The dose is 0.5 mL for each injection. -
Diplomarbeit/Diploma Thesis
DIPLOMARBEIT/DIPLOMA THESIS Titel der Diplomarbeit / Title of the Diploma Thesis “An evaluation of the accuracy of drug – related InChI & InChIKey on ChemSpider, DrugBank, PharmXplorer, PubChem and Wikipedia“ verfasst von / submitted by Joachim Tscherny angestrebter akademischer Grad / in partial fulfilment of the requirements for the degree of Magister der Pharmazie (Mag.pharm.) Wien, 2018 / Vienna, 2018 Studienkennzahl lt. Studienblatt / A 449 degree programme code as it appears on the student record sheet: Studienrichtung lt. Studienblatt / Diplomstudium Pharmazie degree programme as it appears on the student record sheet: Betreut von / Supervisor: Univ.-Prof. Mag. Dr. Gerhard Ecker II Acknowledgments Foremost, I would like to thank my supervisor Gerhard Ecker for the opportunity for realizing this project. Through these thesis, I was able to expand my knowledge extensively. Furthermore, I would like to thank Daniela Digles, who especially supported me at the beginning of my work with the Knime Analytics Platform. I would also like to express my gratitude to Norbert Haider, who provided the data from PharmXplorer. I would like to express my appreciation to the developers of the KNIME Analytical Platform – I could not have carried out the type of computational work without access to this software. I would like to take this opportunity to thank my family, especially Mom, Dad and my sister Katharina, for the continuous and unconditional support they have given me throughout my duration of study. And finally, I extend my personal gratitude to Martina for all the love, patience, and guidance she has given me during the last years. “lucundi acti labores” (Marcus Tullius Cicero, Brutus 70) III IV Abstract Freely available online resources such as ChemSpider, DrugBank, PubChem, and Wikipedia are widely used for obtaining information on drugs.