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Streptococcus Anginosus Lung Infection and Empyema: a Case Report and Review of the Literature

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Streptococcus Anginosus Lung Infection and Empyema: a Case Report and Review of the Literature University of Louisville Journal of Respiratory Infections CASE REPORT Streptococcus anginosus Lung Infection and Empyema: A Case Report and Review of the Literature Nishita Tripathi1∗, MD; Kuldeep Ghosh2, MD; Anupama Raghuram1, MD 1Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, USA; 2Division of Internal Medicine, Metropolitan Hospital, New York Medical College, New York City, NY, USA ∗[email protected] Recommended Citation: Tripathi N, Ghosh K, Raghuram A. Streptococcus anginosus lung infection and empyema: A case report and review of the literature. Univ Louisville J Respir Infect 2021; 5(1): Article 14. Abstract We report a patient with empyema in the setting of an unre- with instillation of tissue plasminogen activator. Subsequently, solved Streptococcus anginosus pneumonia for over a month he required a video-assisted thoracoscopy with decortication after two courses of antimicrobial treatment. A chest com- and drainage of empyema, followed by a remarkable improve- puted tomography (CT) revealed a localized pleural fluid col- ment in his overall condition. Our case highlights the infec- lection. The pleural fluid cultures grew S. anginosus resis- tions caused by the Streptococcus milleri group (SMG) in indi- tant to clindamycin and erythromycin. The patient was treated viduals with an unresolved pneumonia. Such patients should with ampicillin-sulbactam plus surgical interventions. Initially, be diagnosed accurately and treated aggressively with rapid the patient underwent CT-guided placement of chest tube and effective interventions. Introduction Case Report Streptococci milleri group (SMG) have been known to A 37-year-old Caucasian male was evaluated in the cause purulent infections.[1] They are commensal or- emergency room (ER) for 4–6 weeks of cough, white ganisms found in the mucosa lining the oral cavity, sputum, shortness of breath, and weight loss. A month oropharynx, gastrointestinal tracts and genitourinary prior to his current presentation, he was diagnosed tracts in both adults and children.[2] These organisms with radiologically confirmed left lower lobar pneumo- have been known to cause periodontal abscess.[2, 3] nia (Figure 1) and was treated with a 4-day course of They are commonly associated with both monomicro- 250 mg of azithromycin as an outpatient. A month after bial and polymicrobial infections. Monomicrobial in- the initial presentation, he reported similar complaints fections are more common in head and neck infec- and was prescribed 100 mg twice a day of doxycycline tions while gastrointestinal infections are polymicro- for 28 days. The patient has worked as a gravedig- bial in nature involving anaerobes.[2, 4] Anaerobic or- ger for 14 years. He smoked one pack of cigarettes per ganisms found in the polymicrobial infection have been day over the last 20 years and had no history of alcohol reported to enhance SMG infections.[4–7] Streptococcus abuse. His medical history was significant for chronic anginosus is strongly associated with infections of the bronchitis and adenomatous colonic polyps diagnosed skin and soft tissue, as well as gastrointestinal and gen- in the past year. itourinary infections.[6] These organisms are unique in their ability to form abscess, which differentiates On physical examination, he had decreased breath them from S. pyogenes and S. agalactaciae.[3] Most of- sounds in the left middle and lower lung fields. Ini- ten, these organisms have been implicated in causing tial workup revealed a white blood cell count (WBC) of parapneumonic effusions and abscess.[8, 9] Identifica- 18,210 cells/mm3. A chest computed tomography (CT) tion of these organisms is essential for timely diagno- showed a left-sided pleural effusion and compressive sis, and aggressive treatment is required. We describe atelectasis of the left lung, consistent with empyema a case of empyema caused by SMG in a patient with an (Figure 2). He was admitted to the hospital for fur- unresolved left-sided pneumonia. ther management. He underwent CT-guided place- ULJRI j https://ir.library.louisville.edu/jri/vol5/iss1/14 1 ULJRI SMG Empyema and Lung Infection Figure 1. Chest X-ray done prior to hospital admission showed left lower lobe pneumonia. Figure 2. Computerized tomography of the chest at hospital admission shows left base pleural collection suggestive of empyema. ULJRI j https://ir.library.louisville.edu/jri/vol5/iss1/14 2 ULJRI SMG Empyema and Lung Infection ment of pleural catheter with tissue plasminogen acti- ple effusion may undergo fibrinopurulent deposition, vator (TPA) irrigation for the drainage of pleural fluid triggered by bacterial invasion leading to the formation during the first 3 days of his admission. A follow-up of empyema. At Stage 3, there is a widespread scar- chest X-ray at day 3 of hospitalization showed a reduc- ring and pleural peeling, causing restriction of lung re- tion in the fluid collection with persistence of left-sided expansion. Increasing prevalence of empyema caused complicated effusion. A panoramic mandibular X-ray by SMG bacteria should raise concern among clini- was performed due to his poor dentition, showing no cians. The predisposing factors for SMG empyema findings of periapical abscess. The microbiological cul- include old age (median ages 60-68), mucosal distur- tures of blood and sputum were negative; however, at bance (e.g., sinusitis, periodontal abscess), excessive al- day 4 of his admission, pleural fluid cultures grew S. cohol consumption, diabetes mellitus, previous surgi- anginosus, which was resistant to clindamycin and ery- cal procedures involving instrumentation in the tho- thromycin (Table 1). Due to the presence of signifi- rax, enteric diseases (e.g., esophageal perforation) and cant fluid on subsequent radiological studies, he un- immunosuppressive states, such as malignancy.[4, 5, derwent video-Assisted thoracoscopic surgery (VATS) 9, 14] Cases of pleural empyema have also been de- with lateral decortication and drainage of empyema scribed in young patients with none of these risk fac- with placement of a chest tube on day 7 of the hospital- tors.[10] The patient in our study was young and had ization. A subsequent CT showed improved atelectasis non-resolving pneumonia as a risk factor. A case se- and consolidation in the left middle and lower lobes ries of 25 patients found that pneumonia was a predis- (Figure 3). The pleural fluid cytology and histopatho- posing factor in around 40 percent of patients who de- logical analysis excluded malignancy. The patient was veloped SMG empyema, thereby stressing the role of started on intravenous (IV) ampicillin-sulbactam 3 mg these organisms in pulmonary infections.[8] According every 6 hours from day 2 of hospitalization until day to another study, pleural effusion was reported in 54.5 12. He was switched to 500 mg of oral amoxicillin dur- percent of patients with SMG infections. The study also ing the last two days of his hospitalization and was pre- found that pleural effusion was more commonly asso- scribed the same for an additional five days after being ciated with SMG infection than infections caused by discharged. The patient improved clinically and was other pathogens, including but not limited to S. pneu- discharged on day 14 of hospitalization. The patient moniae.[15] Our patient also initially presented with a continued to show remarkable marked improvement loculated empyema, which was consistent with previ- during subsequent outpatient follow-up appointments. ously reported cases. Although our patient had poor A radiological assessment three months after his ad- dentition on an oral examination, he did not have any mission to the hospital showed complete resolution of periodontal abscess, which was unique since dental ab- the left-sided empyema (Figure 4). scess was found to be associated with 40 percent of pa- tients with SMG empyema.[4] Therefore, thorough oral examination should be conducted in suspected cases. Discussion Since SMG are not commonly considered pathogens when evaluating patients for sputum culture, it is often We herein present a case of pleural empyema caused difficult to distinguish them from contaminants. There- by S. anginosus in a young patient with an unresolved fore, physicians must assess the patients who have a pneumonia. Since the SMG are not the most common positive sputum bacterial culture carefully. pathogens known to cause empyema in the United States, it is important to suspect them in patients who SMG empyema should be treated aggressively with an- do not improve on empiric antibiotic therapy.[10] timicrobial drugs in combination with surgical inter- ventions. The antimicrobial therapy may be guided Pleural empyema is a bacterial infection resulting in by susceptibility studies. SMG are generally suscep- the formation of pus in the pleural cavity.[10] It is tible to beta-lactam agents. Commonly used agents an uncommon complication of community-acquired include penicillin, ampicillin, and cephalosporin. For pneumonia (CAP), with approximately 32,000 cases per those allergic to penicillin, erythromycin, clindamycin year in the United States. Around 20 percent of pa- or vancomycin could be used as alternatives.[4, 5] tients with pneumonia develop a parapneumonic ef- However, cases of resistance to erythromycin and clin- fusion, which may lead to empyema.[11] The mean damycin have been reported, consistent with our case time for the development of empyema has been re- report.[16] The antibiotics
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