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(12) United States Patent (10) Patent No.: US 9.220,294 B2 Mccullough (45) Date of Patent: Dec

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(12) United States Patent (10) Patent No.: US 9.220,294 B2 Mccullough (45) Date of Patent: Dec USOO922O294B2 (12) United States Patent (10) Patent No.: US 9.220,294 B2 McCullough (45) Date of Patent: Dec. 29, 2015 (54) METHODS AND DEVICES USING CANNABIS USPC .......................................... 424/725, 448, 449 VAPORS See application file for complete search history. (71) Applicant: Timothy McCullough, Stillwater, MN (56) References Cited (US) U.S. PATENT DOCUMENTS (72) Inventor: Timothy McCullough, Stillwater, MN (US) 3,270,437 A 9, 1966 Castillo et al. 4,543.275 A 9, 1985 Akashi et al. 4,913,865 A 4, 1990 Tovotama (*) Notice: Subject to any disclaimer, the term of this 5,095,921 A 3, 1992 E. et al. patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days. (Continued) (21) Appl. No.: 14/264,999 FOREIGN PATENT DOCUMENTS y x- - - 9 WO WO-94O9842 A1 5, 1994 (22) Filed: Apr. 29, 2014 WO WO-0176768 A1 10, 2001 (65) Prior Publication Data (Continued) US 2015/0223515 A1 Aug. 13, 2015 OTHER PUBLICATIONS Hazekamp et al. Evaluation of a Vaporizing Device (Volcanol) for Related U.S. Application Data the Pulmonary Administration of Tetrahydrocannabinol. Journal of (60) Provisional application No. 61/938,577, filed on Feb. Pharmaceutical Sciences, vol. 95, Issue 6, Apr. 24, 2006.* 11, 2014. (Continued) (51) Int. Cl. A6M 16/00 (2006.01) Primary Examiner — Cachet Sellman A24B I3/00 (2006.01) (74) Attorney, Agent, or Firm — Schwegman Lundberg & A6M II/4 (2006.01) Woessner, PA. A6 IK3I/352 (2006.01) BOLD II/00 (2006.01) (57) ABSTRACT B05D L/40 (2006.01) A method of purifying at least one of THC and CBD from a A61M 15/00 (2006.01) cannabis-containing composition includes heating the can (52) U.S. Cl. nabis-containing composition to a temperature Sufficient to CPC ............... A24B 13/00 (2013.01); A61 K3I/352 volatilize at least one of THC and CBD into a vapor and (2013.01); A61M II/041 (2013.01); A61M condensing the vaporona Substrate. A drug delivery cartridge II/042 (2014.02); B0ID 1 1/00 (2013.01); includes a substrate coated with at least one of THC and CBD B05D 1/40 (2013.01); A61M 15/002 (2014.02); and configured to allow for passage of air through the car A61M 15/0028 (2013.01); A61M 15/0045 tridge to volatilize at least one of THC and CBD for inhalation (2013.01); A61M 15/0066 (2014.02); A61M by a user to induce a medicinal or therapeutic effect to the 2207/00 (2013.01) USC. (58) Field of Classification Search CPC .................................................... A61K 31 (352 21 Claims, 15 Drawing Sheets 326-Oe:z:x:::::::2::22:22:2:::222222222222*222222:32:22.22:22 afte:a::tza" Doooooooooooooootfolio3.18 Doooooooooo 34 332 US 9.220,294 B2 Page 2 (56) References Cited FOREIGN PATENT DOCUMENTS U.S. PATENT DOCUMENTS WO WO-2008, 134668 A2 11/2008 WO WO-2010, 111232 A9 3, 2011 5,224,498 7, 1993 Deevi et al. WO WO-2013O83631 A1 6, 2013 5,269,327 12, 1993 Counts et al. WO WO-2013, 164761 A1 11, 2013 5,878,752 3, 1999 Adams et al. WO WO-2015.123064 A1 8, 2015 5,935,388 8, 1999 Meszaros WO WO-2015 123317 A1 8, 2015 6,045,864 4, 2000 Lyons et al. 6,095,153 8, 2000 Kessler et al. OTHER PUBLICATIONS 6,513,524 2, 2003 Storz ........................ 128,203.26 6,589,395 T/2003 Meili “Big Pharma's Weed Winner', online). The Daily Beast, retireved 6,630,507 10, 2003 Hampson et al. on Apr. 29, 2014). Retrieved from the Internet: <URL: http://www. 6,909,839 6, 2005 Wang et al. thedailybeast.com/articles/2014/01/24/how-one-pharmaceutical 7,025,992 4, 2006 Whittle 7,088.914 8, 2006 Whittle et al. company-could-become-the-safest-and-most-trusted-of-all-can 7,279.421 10, 2007 Suzuki nabis-dealers.html#url=/articles/2014/01/24/how-one 7,344,736 3, 2008 Whittle et al. pharmaceutical-company-could-become->, Jan. 24, 2014), 2 pgs. 7,399,872 T/2008 Webster et al. 7,402,686 T/2008 Duchek “Decarboxylating Cannabis: Turning THCA into THC, online. 7,524,881 4, 2009 Goodwin et al. retrieved on Apr. 29, 2014). Retrievefd from the Internet: <URL: 7,540,286 6, 2009 Cross et al. http://www.marijuanagrowershq.com/decarboxylating-cannabis 7,622,140 11/2009 Whittle et al. turning-thca-into-thc/>, (Aug. 14, 2012), 36 pgs. 7,651,570 1, 2010 Brcka “Decarboxylation of cannabis: scientific info about temps and 7,674,922 3, 2010 Burdick et al. times', online. archived on Jul. 5, 2013. Retrieved from the 7,741,365 6, 2010 Makriyannis et al. Internet: <URL: http://cannabischris.com/2012/10/decarboxylation 8,034,843 10, 2011 Whittle et al. 8, 147,898 4, 2012 Coates et al. of-cannabis/>, (Oct. 31, 2012), 5 pgs. 8.481,091 T/2013 Ross “Evaluation of Volcano(r) Vaporizer for the Efficient Emission of 8,512,767 8, 2013 Ross THC, CBD, CBN and the Significant Reduction And/Or Elimination 2002.0117175 8, 2002 Kottayil et al. of Polynuclear-Aromatic (PNA) Analytes Resultant of Pyrolysis”. 2003/0221625 12, 2003 Toda et al. prepared by Chemic Laboratories, Canton, MA online. retrieved 2004/0096402 5, 2004 Hodges et al. on Apr. 29, 2014. Retrieved from the Internet: <URL: http://www. 2004/O126326 T/2004 Rabinowitz et al. 2004/O138293 T/2004 Werner et al. maps.org/mmj/vaporizerstudy4.15.03.pdf>. (2003), 57 pgs. 2004/O147767 T/2004 Whittle et al. ................ 549,390 “Hash Oil”, online). retrieved on Apr. 29, 2014). Retrieved from the 2005/0042172 2/2005 Whittle ....... ... 424/46 Internet: <URL: http://en.wikipedia.org/wiki/Hash oil, (last 2005, OO63686 3, 2005 Whittle et al. ................ 392,390 modified on Apr. 27, 2014), 4pgs. 2006/0039959 2, 2006 Wessling "SativeX(R', online), (C) 2014 GW Phamaceuticals. retrieved on Apr. 2006.0160888 T/2006 Kottayil et al. 29, 2014). Retrieved from the Internet: <URL: http://gwpharm.com/ 2006.0167084 T/2006 Dudley Sative.aspx>. (2014), 2 pgs. 2007/002O193 1/2007 de Vries et al. “Total Sublimation—Sublimator in Action', online. retrieved on 2007/004.1994 2, 2007 McDowell 2007/0049645 3, 2007 Mechoulam et al. Apr. 29, 2014). Retrieved from the Internet: <URL: http:// 2007/0099987 5/2007 Weiss et al. thehighcanadian.wordpress.com/tag/total-Sublimation/>, (2014), 3 2008/00571 17 3, 2008 Werner et al. pg.S. 2008. O181942 T/2008 Zajicek "Vacuum and fractional distillation', online). retrieved on Apr. 29. 2008/0216828 9, 2008 Wensley et al. 2014. Retrieved from the Internet: <URL: http://boards.cannabis. 2008.O255224 10, 2008 Blum com/concentrates. 182951-vacuum-fractional-distillation.html>, 2008.O262099 10, 2008 Whittle et al. (2014), 5 pgs. 2008/0275237 11, 2008 Arslantas et al. "Vaporizer (inhalation device)”, online). WikipediaR), the free ency 2008/0306285 12, 2008 Hale et al. clopedia, retrieved on Apr. 29, 2014). Retrieved from the Internet: 2009,0005461 1/2009 Nagarkatti et al. <URL: http://en.wikipedia.org/wiki/Vaporizer (inhalation de 2009/O197941 8, 2009 Guy et al. vice)>, (modified on Mar. 21, 2014), 4pgs. 2009/0324797 12, 2009 Bobzin et al. “Volcano Vaporizer”, online. (C) 2013 Storz & Bickel GMBH & Co. 2010, 0012118 1, 2010 Storz ........................ 128,203.15 KG. retrieved on Dec. 10, 2013. Retrieved from the Internet: <URL: 2010/01 19606 5, 2010 Whittle http://volcanovaporizer.com/about , (2013), 4pgs. 2010. O158973 6, 2010 Weiss et al. 2010/0204312 8, 2010 McAllister et al. “Volcano R. Vaporization System”. online. retrieved on May 15, 2010/0204443 8, 2010 Gazit et al. 2014. Retrieved from the Internet: <URL: http://www.storZ-bickel. 2010/0239635 9, 2010 McClain et al. com/vaporizer? volcano-technology.html>, (2014). 4pgs. 2010/0239693 9, 2010 Guy et al. “Why Vaporize?”. online. (C) 2013 Storz & Bickel GMBH & Co, 2010/0249223 9, 2010 DiMarzo et al. KG. retrieved on Dec. 10, 2013, Retrieved from the Internet: <URL: 2011/OO52694 3, 2011 Stinchcomb et al. http://volcanovaporizer.com/why-vapef>, (2013), 4pgs. 2011/OO711.78 3, 2011 Makriyannis et al. Welch, William M., "Vaporizers, e-cigs of the pot world, are boom 2011/OO73120 3, 2011 Adamic ing', online. USA Today, retrieved on Apr. 29, 2014). Retrieved 2011/OO82195 4, 2011 Guy et al. from the Internet: <URL: http://www.usatoday.com/story/money/ 2011/0097.283 4, 2011 Van Damme et al. business/2014/03/15/marijuana-vapporizing-gains/6042675/>. 2012fO3O4990 12, 2012 Todd (Mar. 17, 2014), 6 pgs. 2012,0311744 12, 2012 Sirkowski "Amazon.com: EZ. Breathe Atomizer Asthmalnhalers, Model it 2013,0087144 4, 2013 Todd EZ100: Health & Personal Care”. Online. Retrieved from the 2013/0178453 T/2013 Rohde et al. Internet: <URL: http://www.amazon.com/EZ-Breathe-Atomizer 2013,0196960 8, 2013 Rohde et al. Asthma-Inhalers-EZ-100/dp/B00DQSTVRQ/ref=pd SXp f pt, 2013/0255702 10, 2013 Griffith, Jr. et al. (Accessed: Mar. 3, 2015), 25 pgs. 2013/0276799 10, 2013 Davidson et al. “Tutorial: Atomizer vs. Cartomizer vs. Clearomizer Overview of 2014f0060554 A1 3, 2014 Collett et al. Atomizer vs. Cartomizer vs. Clearomizer'. Online. Retrieved from 2015. O136158 A1 5/2015 Stevens et al. the Internet: <URL: https://www.misthub.com/blog/ 2015,0223523 A1 8, 2015 Mccullough tutorialatomizervsclearomizer/>. (Accessed: Mar. 3, 2015), 15 pgs. US 9.220,294 B2 Page 3 (56) References Cited “Open vape: Home page'. Online. Retrieved from the Internet: <URL: http://www.openvape.com/>. (Accessed on: Jun. 30, 2015), 2 OTHER PUBLICATIONS pg.S. Chanbers, Rachel, "Leafly: What is Dabbing and How Do Dabs “Alexza Pharamaceuticals: Staccato Platform Details'.
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