DOCSLIB.ORG

Issue on Biocatalysis

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Issue on Biocatalysis Bioorganic Chemistry 93 (2019) ii-xviii Contents lists available at ScienceDirect Bioorganic Chemistry journal homepage: www.elsevier.com/locate/bioorg Graphical Abstracts/Bioorganic Chemistry 93 (2019) ii-xviii REGULAR ARTICLES Aminonaphthalimide hybrids of mitoxantrone and amonafide as anticancer and fluorescent Bioorganic Chemistry 93 (2019) 103287 cellular imaging agents Alex D. Johnsona, Rodrianne Zammitb, Jasmine Vellac, Mario Valentinoc, Joseph A. Buhagiarb, David C. Magria aDepartment of Chemistry, Faculty of Science, University of Malta, Msida, MSD 2080, Malta bDepartment of Biology, Faculty of Science, University of Malta, Msida, MSD 2080, Malta cDepartment of Physiology and Biochemistry, Faculty of Medicine & Surgery, University of Malta, Msida, MSD 2080, Malta Adapalene inhibits ovarian cancer ES-2 cells growth by Bioorganic Chemistry 93 (2019) 103315 targeting glutamic-oxaloacetic transaminase 1 Qiqi Wangb, Qingzhe Zhanga, Shanshan Luana, Kaiyin Yanga, Mengzhu Zhenga, Kezhen Lic, Lixia Chenb, Hua Lia aHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China bWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China cCancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Synthesis of novel nitroreductase enzyme-activated nitric oxide Bioorganic Chemistry 93 (2019) 103318 prodrugs to site-specifically kill bacteria Hailey A.J. Hibbarda, Melissa M. Reynoldsa,b aDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA bSchool of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA Graphical Abstracts Design and synthesis of substituted Bioorganic Chemistry 93 (2019) 103317 dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors Sravani Sanaa, Ramya Tokalaa, Deepti Madanlal Bajajb, Narayana Nageshd, Kiran Kumar Bokarad, Gaddam Kiranmaid, Uppu Jaya Lakshmia, Swapna Vadlamanic, Venu Tallab, Nagula Shankaraiaha aDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India bDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India cDepartment of Pharmaceutical Technology in Process Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India dCSIR-Centre for Cellular and Molecular Biology, Medical Biotechnology Complex, ANNEXE II, Uppal Road, Uppal, Hyderabad 500007, India Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues Bioorganic Chemistry 93 (2019) 103316 Zefeng Zhaoa, Guangxin Liub, Yufeng Menga, Jiale Tiana, Xufei Chena, Meilun Shenb, Yuexuan Lia, Bingyao Lia, Cong Gaoa, Shaoping Wua, Cuiqin Lib, Xirui Hec, Ru Jiangd, Mingcheng Qiane,f, Xiaohui Zhenga aSchool of Pharmacy, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi’an, China bKey Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, China cDepartment of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China dSchool of Pharmacy, The Fourth Military Medical University, Xi’an, Shaanxi, China eDepartment of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, Jiangsu, China fLaboratory for Medicinal Chemistry, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium Design, synthesis and preliminary in-vitro studies of novel boronated monocarbonyl Bioorganic Chemistry 93 (2019) 103324 analogues of Curcumin (BMAC) for antitumor and ß-amiloyd disaggregation activity Emanuele Azzia, Diego Albertib, Stefano Parisottoa, Alberto Oppedisanoa, Nicoletta Prottic,d, Saverio Altieric,d, Simonetta Geninatti-Crichb, Annamaria Deagostinoa aDepartment of Chemistry, University of Turin, via P. Giuria 7, 10125 Turin, Italy bDepartment of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, 10126 Turin, Italy cDepartment of Physics, University of Pavia, via Agostino Bassi 6, Pavia 27100, Italy dNuclear Physics National Institute (INFN), Unit of Pavia, via Agostino Bassi 6, Pavia 27100, Italy Design, synthesis and biological evaluation of novel copper- Bioorganic Chemistry 93 (2019) 103322 chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments Yeheng Zhoua,d, Wei Suna, Jiale Pengd, Hui Yana, Li Zhangd, Xingyong Liud, Zhili Zuoa,b,c,d aState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China bYunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, PR China cUniversity of Chinese Academy of Sciences, Beijing 100049, PR China dSchool of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, PR China iii Graphical Abstracts Design, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea Bioorganic Chemistry 93 (2019) 103323 derivatives as potential antitumor agents against non-small cell lung cancer cells Synthesis of some thiadiazine-thiourea derivative 5a-p Fatma A.F. Ragaba, Salah A. Abdel-Azizb, Marwa Kamelc, Abdelsalam Mohamed A. Oufb, Cytotoxicity assay against NSCLC Heba Abdelrasheed Allama 5d, 5i, 5j most potent compounds aDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo P.O. Box, 11562, Egypt 5i bDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt 5d 5j cDepartment of Cancer Biology, Unit of Pharmacology, National Cancer Institute, Cairo University, Egypt Biological assessment VEGFR2 B-RAF MMP9 Selectivity index against WI-38 Further evaluation for 5j (most promising) Cell cycle analysis Apoptosis Invasion and migration assays Docking 5d,5i, 5j are potenƟaů targeƟng agents against NSCLC Identification of a potent and selective gametocytocidal Bioorganic Chemistry 93 (2019) 103321 antimalarial agent from the stem barks of Lophira lanceolata Annalisa Lopatrielloa, Harouna Soréb, Annette Habluetzelc, Silvia Parapinid, Sarah D'Alessandrod, Donatella Taramellie, Orazio Taglialatela-Scafatia aDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy bCentre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou, Burkina Faso cSchool of Pharmacy, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino, Italy dDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy eDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates Bioorganic Chemistry 93 (2019) 103319 as tubulin polymerization inhibitors targeting the colchicine binding site Yong Yin, Bao-Ping Lian, Yuan-Zheng Xia, Yu-Ying Shao, Ling-Yi Kong Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People’s Republic of China Exploration of Pd-catalysed four-component tandem reaction for one-pot Bioorganic Chemistry 93 (2019) 103314 assembly of pyrazolo[1,5-c]quinazolines as potential EGFR inhibitors Arshad J. Ansaria, Gaurav Joshib, Umesh Prasad Yadavc, Antim K. Mauryad, Vijai K. Agnihotrid, Sourav Kalrac, Raj Kumarb, Sandeep Singhc, Devesh M. Sawanta aSchool of Chemical Sciences and Pharmacy, Central University of Rajasthan NH-8, Bandarsindri, Ajmer 305817, Raj, India bLaboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151001, Punjab, India cLaboratory of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda 151001, Punjab, India dNatural Product Chemistry and Process Development Division, CSIR-IHBT, Palampur, Himachal Pradesh 176061, India iv Graphical Abstracts Novel tribenzylaminobenzolsulphonylimine based Bioorganic Chemistry 93 (2019) 103313 on their pyrazine and pyridazines: Synthesis, characterization, antidiabetic, anticancer, anticholinergic, and molecular docking studies Gulnar Mamedovaa, Adila Mahmudovaa, Sabir Mamedova, Yavuz Erdenb, Parham Taslimic, Burak Tüzünd, Recep Tasc, Vagif Farzaliyeva, Afsun Sujayeva, Saleh H. Alwasele, Ilhami Gulçinf aLaboratory of Faine Organic Synthesis, Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences, 1029 Baku, Azerbaijan bDepartment of Molecular Biology and Genetics, Faculty of Science, Bartin University, 74100 Bartin, Turkey cDepartment of Biotechnology, Faculty of Science, Bartin University, 74100 Bartin, Turkey dDepartment of Chemistry, Faculty of Science, Cumhuriyet University, 58140 Sivas, Turkey eDepartment of Zoology,
Load more

Recommended publications
  • Chemistry Courses 2005-2006
    Chemistry Courses 2005-2006 Autumn 2005 Chem 11101 General Chemistry I, Variant A Lee Chem 11102 General Chemistry I, Variant B Norris Chem 12200 Honors General Chemistry I Levy Chem 22000 Organic Chemistry I Yu Chem 22300 Intermediate Organic Chemistry Mrksich Chem 26100 Quantum Mechanics Mazziotti Chem 30100 Advanced Inorganic Chemistry Hopkins Chem 30900 Bioinorganic Chemistry He Chem 32100 Physical Organic Chemistry I Ismagilov Chem 32200 Organic Synthesis and Structure Rawal Chem 32600 Protein Fundamentals Piccirilli Chem 36100 Wave Mechanics & Spectroscopy Butler Chem 36400 Chemical Thermodynamics Dinner Winter 2006 Chem 11201 General Chemistry II, Variant A Scherer Chem 11202 General Chemistry II, Variant B Butler Chem 12300 Honors General Chemistry II Dinner Chem 20100 Inorganic Chemistry I Hillhouse Chem 22100 Organic Chemistry II Rawal Chem 23100 Honors Organic Chemistry II Kozmin Chem 26200 Thermodynamics Norris Chem 26700 Experimental Physical Chemistry Levy Chem 30200 Synthesis & Physical Methods in Inorganic Chemistry Jordan Chem 30400 Organometallic Chemistry Bosnich Chem 32300 Tactics of Organic Synthesis Yamamoto Chem 32400 Physical Organic Chemistry II Mrksich Chem 36200 Quantum Mechanics Freed Chem 36300 Statistical Mechanics Mazziotti Chem 38700 Biophysical Chemistry Lee Spring 2006 Chem 11301 General Chemistry III, Variant A Kozmin Chem 11302 General Chemistry III, Variant B Guyot-Sionnest Chem 20200 Inorganic Chemistry II Jordan Chem 22200 Organic Chemistry III Kent Chem 23200 Honors Organic Chemistry III Yamamoto Chem 22700 Advanced Organic / Inorganic Laboratory (8 students) He Chem 26300 Chemical Kinetics and Dynamics Sibner Chem 26800 Computational Chemistry & Biology Freed Chem 30600 Chemistry of the Elements Hillhouse Chem 31100 Supramolecular Chemistry Bosnich Chem 32500 Bioorganic Chemistry Piccirilli Chem 32900 Polymer Chemistry Yu Chem 33000 Complex Systems Ismagilov Chem 36500 Chemical Dynamics Scherer Chem 36800 Advanced Computational Chemistry & Biology Freed .
    [Show full text]
  • Curriculum of Department of Pharmacy (6-Year Program)
    Curriculum of Department of Pharmacy (6-year program) 1st year 2nd year 3rd year 4th year 5th year 6th year Basic Subjects for Pharmacy Student; Lectures and Practices of Basic Specialized Lectures and Practices Drug Therapy and its Related Practical Training and Beginning of Research for Graduation and SGL and more Sciences Research for Graduation Advanced Lectures Fundamental Education Professional Education Ⅰ Professional Education Ⅱ ■Humanism ■Humanism ■Preparatory Pharmacy Education ■Professional Pharmacy Education ■Practical Training ■Advanced Education Introduction to Humanism I Introduction to Humanism Ⅱ English for Pharmacy Oriental Medicine Preparation for Practical Training Research for Graduation Pharmacotherapeutics Practical Training in Hospital Advanced Clinical Training ■Preparatory Pharmacy Education ■Professional Pharmacy Education Drug Information Science Practical Training in Community Phrarmacy General Pharmacy Practice II ■Introduction of Pharmacy Basic English and English for Pharmacy Clinical Chemistry Drug Development and Production Japanese Traditional Medicine Invitation to Pharmacy Basic Statistics Synthesis of Target Molecules Pharmacy and Society ■Advanced Education Clinical Pharmacokinetics Early Exposure to Pharmacy Practical Trainings for Pharmacy Bioorganic Chemistry General Pharmacy Practice Research for Graduation Clinical Drug Evaluation Students Pharmaceutical Health Care Training Medical Economy Natural Products Chemistry ■Practical Training Education Drug Safty Evaluation and Pharmacoepidemiology
    [Show full text]
  • Recreating Ancient Metabolic Pathways Before Enzymes Kamila B
    Recreating ancient metabolic pathways before enzymes Kamila B. Muchowska, Elodie Chevallot-Beroux, Joseph Moran To cite this version: Kamila B. Muchowska, Elodie Chevallot-Beroux, Joseph Moran. Recreating ancient metabolic path- ways before enzymes. Bioorganic and Medicinal Chemistry, Elsevier, 2019, 27 (12), pp.2292-2297. 10.1016/j.bmc.2019.03.012. hal-02516541 HAL Id: hal-02516541 https://hal.archives-ouvertes.fr/hal-02516541 Submitted on 23 Mar 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Graphical Abstract To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Recreating ancient metabolic pathways Leave this area blank for abstract info. before enzymes Kamila B. Muchowskaa* , Elodie Chevallot-Berouxa, and Joseph Morana* University of Strasbourg, CNRS, ISIS UMR 7006, 67000 Strasbourg, France Bioorganic & Medicinal Chemistry journal homepage: www.elsevier.com Recreating ancient metabolic pathways before enzymes Kamila B. Muchowska,a* Elodie Chevallot-Beroux,a and Joseph Morana* a University of Strasbourg, CNRS, ISIS UMR 7006, 67000 Strasbourg, France. ARTICLE INFO ABSTRACT Article history: The biochemistry of all living organisms uses complex, enzyme-catalyzed metabolic reaction Received networks.
    [Show full text]
  • Century Journals Project (CJP)
    China National Knowledge Infrastructure: Century Journals Project (CJP) Complete Title List - Series E (at July, 2008) Please note: Titles are sorted by Series, then Language (with English titles appearing first) , then by Pinyin title in English phonetic order. Earliest Control Journal Title Language Title in Pinyin Glossing of Title Former Title Freq. ISSN # CN # Publisher Issue in Status URL Notes Code Series CNKI E 南京医科大学学报 (英文版) English Nanjing Yike Daxue Xuebao (Yingwenban) Journal of Nanjing Medical University Journal of Nan bimonthly 1007-4376 32-1443/R 南京医科大学 1994/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L NJYY E 上海第二医科大学学报 (外文版) English Shanghai Dier Yike Daxue Xuebao Journal of Shanghai Second Medical University Journal of Sha semiannual 1001-6686 31-1589/R 上海第二医科大学 1987/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L SHEI (Yingwenban) (Foreign Language Edition) E 生物医学与环境科学 (英文版) English Shengwu Yi Xue Yu Huan Jing Ke Xue Biomedical and Environmental Sciences Biomedical an bimonthly 0895-3988 11-2816/Q 中国预防医学科学 1989/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L SWYX (Yingwenban) E 生殖与避孕 (英文版) English Shengzhi Yu Biyun (Yingwenban) Journal of Reproduction and Contraception Reproduction quarterly 1001-7844 31-1555/R 上海市计划生育科 1994/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L SZBW E 世界针灸杂志 (英文版) English Shijie Zhenjiu Zazhi (Yingwenban) World Journal of Acupuncture-Moxibustion World Journa quarterly 1003-5257 11-2892/R 世界针灸学会联合会 1992/01 Active http://china.eastview.com/kns50/Navi/Bridge.aspx?L
    [Show full text]
  • A Survey of Carbon Fixation Pathways Through a Quantitative Lens
    Journal of Experimental Botany, Vol. 63, No. 6, pp. 2325–2342, 2012 doi:10.1093/jxb/err417 Advance Access publication 26 December, 2011 REVIEW PAPER A survey of carbon fixation pathways through a quantitative lens Arren Bar-Even, Elad Noor and Ron Milo* Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel * To whom correspondence should be addressed. E-mail: [email protected] Received 15 August 2011; Revised 4 November 2011; Accepted 8 November 2011 Downloaded from Abstract While the reductive pentose phosphate cycle is responsible for the fixation of most of the carbon in the biosphere, it http://jxb.oxfordjournals.org/ has several natural substitutes. In fact, due to the characterization of three new carbon fixation pathways in the last decade, the diversity of known metabolic solutions for autotrophic growth has doubled. In this review, the different pathways are analysed and compared according to various criteria, trying to connect each of the different metabolic alternatives to suitable environments or metabolic goals. The different roles of carbon fixation are discussed; in addition to sustaining autotrophic growth it can also be used for energy conservation and as an electron sink for the recycling of reduced electron carriers. Our main focus in this review is on thermodynamic and kinetic aspects, including thermodynamically challenging reactions, the ATP requirement of each pathway, energetic constraints on carbon fixation, and factors that are expected to limit the rate of the pathways. Finally, possible metabolic structures at Weizmann Institute of Science on July 3, 2016 of yet unknown carbon fixation pathways are suggested and discussed.
    [Show full text]
  • Editorial Highlights for Organi Chemistry: Current Research
    n ISSN: 2161-0401 Organic Chemistry: Current Research Editorial Editorial Note on Bioorganic Chemistry Sandhya Kille Department of Microbiology, Acharya Nagarjuna University, India EDITORIAL structure-function studies of therapeutics, and bio conjugates. Students focused on this area at Oregon Bioorganic chemistry could also be a rapidly growing develop a solid foundation in synthetic chemistry and even content that mixes science and biochemistry. It’s that have the good thing about the outstanding branch of bioscience that deals with the study of biochemistry/molecular biology research environment at biological processes using chemical methods. UO. Bioorganic chemistry applies the principles and Protein and enzyme function are samples of those techniques of chemistry to unravel problems of biological processes. Sometimes biochemistry is utilized relevance, taking inspiration from biology to develop new interchangeably for bioorganic chemistry; the excellence chemical processes. being that bioorganic chemistry is chemistry that's Cornell bioorganic chemists emphasize chemical and focused on the biological aspects. While biochemistry molecular approaches to solving important biological aims at understanding biological processes using problems. Research areas include the applying of chemistry, bioorganic chemistry attempts to expand synthetic and scientific discipline to the study of enzymes, organic-chemical researches (that is, structures, metabolic pathways and nucleic acids. This includes the synthesis, and kinetics) toward biology. event of mechanism-based enzyme inhibitors; elucidation When investigating metalloenzymes and cofactors, of enzyme mechanism and structure and studies of bioorganic chemistry overlaps bioinorganic chemistry. coenzyme reactivity. Chemical investigations are extended Bioorganic Chemistry and Chemical Biology, broadly to studies of receptor recognition, hormone and drug defined, are fields during which organic synthetic activity, and also the mechanism of chemical chemistry plays an unlimited role within the life sciences.
    [Show full text]
  • Laboratory Classes in Bioorganic Chemistry
    MINISTRY OF HEALTH OF REPUBLIC OF BELARUS VITEBSK STATE MEDICAL UNIVERSITY LABORATORY CLASSES IN BIOORGANIC CHEMISTRY L.G. Hidranovich, O.A. Khodos ( 2 - e « З Д / ) For Foreign students of the 1-st year Vitebsk 20t£ УДК 54 (042.3/4) ББК 24.239 L.G. Hidranovich, О.Л. Khodos LABORATORY CLASSES IN BIOORGANIC CHEMISTRY for foreign students of the 1-sl year: Manual./ L.G. Hidranovich, O.A. Khodos. - Vitebsk: v s m u , 20i b - 128 p. ( 2 - е м а д д ISBN 978-985-466-5$S‘-3 This issue contains program questions, problems, laboratory' works for the classes in bioorgamc chemistry, examination questions, tests, reference tables.The issue was wrote according to the typical educational program for the students o f higher medical educa­ tional establishments. Утверждено и рекомендовано к изданию Центральным учебно-научно­ методическим Советом непрерывного медицинского и фармацевтического образо­ вания Витебского государственного медицинского университета, 21.04________ 2007 г , протокол №4. ISBN 978-985-466-581-3 У Д К 54 (042.3/4) ББК 24.239 © Гидранович Л.Г., Ходос О А., 20/3 ©УО «Витебский государственный медицинский университет», 20'Й CONTENTS Thematic p!a:: of the lectures. 4 Thematic plan of the laboratory classes. 5 Accident prevention. 6 Theme 1. Classification and FJPAC nomenclature of organic com­ 7 pounds. Theme 2. Electronic structure of chemical bonds. Inductive and reso­ 9 nance effects. Theme 3. Stereochemistry of organic compounds. 11 Configuration and conformation of the organic compounds. Theme 4 Acid-base properties of organic compounds. 14 Theme 5. Classification and mechanisms of the reactions in organic 16 chemistry Saturated, unsaturated and aromatic hydrocarbons.
    [Show full text]
  • Bioorganic Chemistry
    Lecture 1. Biomedical and Bioorganic Chemistry Lecturer Yanovska Anna Olexandrivna Calculate grade: • Total (200) • General module (80 total) • Tests (Nomenclature - 10 points, Heterofunctional compounds – 14 points, Lipids – 14 points, Aminoacids, Peptides – 14 points). • Individual homework (30 possible) • 20 points (laboratory works) • 18 points work in class • Grades: • 170-200 - excellent • 169 – 140 - good • 139 – 120 – satisfied • Less than 120 - unsatisfied Organic chemistry is the chemistry of compounds of carbon. Bioorganic chemistry is the part of organic chemistry that studies the carbon compounds, which are present in the living organism – the so-called biomolecules. The major biomolecules are carbohydrates, proteins, lipids, and nucleic acids. It also studies drugs and their derivatives. By carbon chain organic compounds are classified in following way: Organic Chemistry • The chemistry of carbon compounds. • What’s special about carbon? – tetravalent (sp3 hybridization) – wide choice in oxidation states – CO2 C, +4 – CH4 C, -4 – bonds well to O, N, halides,itself,etc. – Covalent bonds are very strong Bond formation in molecules of organic compounds Functional Groups Term used to refer to parts of organic molecules where reactions tend to occur. By amount of functional groups and their type organic compounds are classified onto - Monofunctional (one functional group): alcohol C2H5-OH, carboxylic acid CH3COOH - Polyfunctional – has two or more same functional groups: HO-CH2-CH2-OH - Heterofunctional – has two or more different functional groups: HO-CH2-CH2-NH2 Functional Group is a part of an organic compound, by which it belongs to class of organic compounds and has specific properties. Structure of Carbon Compounds • There are three hybridization states and geometries found in organic compounds: – sp3 Tetrahedral – sp2 Trigonal planar – sp Linear Hydrocarbons (contain only H and C) • Four types: – Alkanes – Alkenes – Alkynes – Aromatic hydrocarbon s Alkanes • Only single bonds.
    [Show full text]
  • Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric
    molecules Review Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction Mufarreh Asmari 1, Xiaoyu Wang 2 , Natalia Casado 3 , Marjan Piponski 4 , Sergiy Kovalenko 5, Liliya Logoyda 6, Rasha Sayed Hanafi 7 and Sami El Deeb 8,* 1 College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia; [email protected] 2 Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA; [email protected] 3 Departamento de Tecnología Química y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/Tulipán s/n, Móstoles, 28933 Madrid, Spain; [email protected] 4 Replek Farm Ltd., st. Kozle 188, 1000 Skopje, North Macedonia; [email protected] 5 Department of Organic and Bioorganic Chemistry, Zaporizhzhia State Medical University, Maiakovskyi avenue 26, 69035 Zaporizhzhia, Ukraine; [email protected] 6 Department of Pharmaceutical Chemistry, I. Horbachevsky Ternopil National Medical University, Maidan Voli 1, 46001 Ternopil, Ukraine; [email protected] 7 Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Citation: Asmari, M.; Wang, X.; Cairo, Cairo 11835, Egypt; rasha.hanafi@guc.edu.eg 8 Casado, N.; Piponski, M.; Kovalenko, Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, S.; Logoyda, L.; Hanafi, R.S.; El Deeb, 38106 Braunschweig, Germany * Correspondence: [email protected]; Tel.: +49-531-391-7301 S. Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Abstract: This review draws attention to the use of chiral monolithic silica HPLC columns for the Separation and Determination: enantiomeric separation and determination of chiral compounds.
    [Show full text]
  • Bioorganic Chemistry
    Hermann Dugas Christopher Penney Bioorganic Chemistry A Chemical Approach to Enzyme Action With 82 Figures Spri nger-Verlag New York Heidelberg Berlin Dr. Hermann Dugas Dr. Christopher Penney Departement de Chimie Connaught Research Institute Universite de Montreal Willowdale, Ontario Montreal, Quebec Canada M2N 5T8 Canada H3C 3Vl Series Editor: Prof. Charles R. Cantor Columbia University Box 608 Havemeyer Hall New York, New York 10027 USA Cover: The green illustration represents the hypothetical mode of binding of a rigid structural analogue of N-benzoyl-L-phenylalanine methyl ester at the active site of a-chymotrypsin. The illustration emphasizes the equilibration toward the favored configuration (see text page 224). The background design is taken from a diagrammatic representation of the primary structure of a-chymotrypsin. After Nature with permission [B.W. Matthews, P.B. Sigler, R. Henderson, and D.M. Blow (1967), Nature 214, 652-656]. Library of Congress Cataloging in Publication Data Dugas, Hermann, 1942- Bioorganic chemistry. (Springer advanced texts in chemistry.) Bibliography: p. Includes index. 1. Enzymes. 2. Biological chemistry. 3. Chemistry,. Organic. I. Penney, Christopher, 1950- joint author. II. Title. m. Series. [DNLM: 1. Biochemistry. 2. Enzymes-Metabolism. QUl35 D866b] QP60 1. D78 574.19'25 80-16222 All rights reserved. No part of this book may be translated or reproduced in any form without written permission from Springer-Verlag. The use of general descriptive names, trade names, trademarks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone.
    [Show full text]
  • 14 Chemistry in the 21St Century
    Ch 14 Chemistry in the 21st century 14 CHEMISTRY IN THE 21ST CENTURY Since the beginning of its modernization at the end of the 18th century, chemistry has been continuously and rapidly developing. Since the basis of this development is through the atomic/molecular theory, we can call these 200 years the era of molecular chemistry. As the beginning of the 21st century approached, chemistry had much success in greatly enlarging its scope. The role of weak interactions was recognized, and the new prospect of supramolecular chemistry opened up. On the other hand, chemistry has a major responsibility to sustain the environment of the earth, and we must find ways for humans and nature to coexist indefinitely, that is, in modern terminology, to achieve sustainable societies. There is much that chemistry and all chemists should do. 14.1 A novel view of matter (a) Detection of weak interaction From the birth of modern chemistry at the end of the 18th century to the end of the 20th century, chemistry has been based on molecules which are composed of atoms and covalent and ionic bonds to connect these. The structure, properties and functions have been explained in terms of molecules. It has been taken for granted that if one can understand each molecule, one can understand the properties and functions of all substances. Chemistry based on such an assumption may be called the molecular chemistry. There were, however, some chemists who suspected such a view might be too shortsighted. Indeed as early as the 1920s, it was already recognized that there were some materials whose structure or properties and functions could not be explicable in terms of molecules.
    [Show full text]
  • A Complete Collection of Chinese Institutes and Universities For
    Study in China——All China Universities All China Universities 2019.12 Please download WeChat app and follow our official account (scan QR code below or add WeChat ID: A15810086985), to start your application journey. Study in China——All China Universities Anhui 安徽 【www.studyinanhui.com】 1. Anhui University 安徽大学 http://ahu.admissions.cn 2. University of Science and Technology of China 中国科学技术大学 http://ustc.admissions.cn 3. Hefei University of Technology 合肥工业大学 http://hfut.admissions.cn 4. Anhui University of Technology 安徽工业大学 http://ahut.admissions.cn 5. Anhui University of Science and Technology 安徽理工大学 http://aust.admissions.cn 6. Anhui Engineering University 安徽工程大学 http://ahpu.admissions.cn 7. Anhui Agricultural University 安徽农业大学 http://ahau.admissions.cn 8. Anhui Medical University 安徽医科大学 http://ahmu.admissions.cn 9. Bengbu Medical College 蚌埠医学院 http://bbmc.admissions.cn 10. Wannan Medical College 皖南医学院 http://wnmc.admissions.cn 11. Anhui University of Chinese Medicine 安徽中医药大学 http://ahtcm.admissions.cn 12. Anhui Normal University 安徽师范大学 http://ahnu.admissions.cn 13. Fuyang Normal University 阜阳师范大学 http://fynu.admissions.cn 14. Anqing Teachers College 安庆师范大学 http://aqtc.admissions.cn 15. Huaibei Normal University 淮北师范大学 http://chnu.admissions.cn Please download WeChat app and follow our official account (scan QR code below or add WeChat ID: A15810086985), to start your application journey. Study in China——All China Universities 16. Huangshan University 黄山学院 http://hsu.admissions.cn 17. Western Anhui University 皖西学院 http://wxc.admissions.cn 18. Chuzhou University 滁州学院 http://chzu.admissions.cn 19. Anhui University of Finance & Economics 安徽财经大学 http://aufe.admissions.cn 20. Suzhou University 宿州学院 http://ahszu.admissions.cn 21.
    [Show full text]