Cancer Biology Seminar Series
LAP and LANDO: Noncanonical functions of autophagy proteins in anti-cancer immunity and neurodegeneration
Tuesday, March 5, 2019 12:00 noon
Dr. Douglas Green https://www.stjude.org/directory/g/douglas-green.html Chair, Immunology Department Co-Leader, Cancer Biology Program Peter C. Doherty Endowed Chair of Immunology
St. Jude Children’s Research Hospital
University of Hawai‘i Cancer Center 701 Ilalo Street Sullivan Conference Center Light refreshments to follow
CURRICULUM VITAE
Name: Douglas R. Green
Address: St. Jude Children’s Research Hospital Dept. Immunology 262 Danny Thomas Place Memphis, TN 38105
Telephone: 901-595-3378 Fax: 901-595-3107
Education: Institution Degree Date
Yale Univ. B.S. (Biology) 1977 M.I.T. none 1977-1978 Yale Univ. Ph.D. (Biology) 1981
Honors:
Magna cum laude Yale Univ. 1977 Distinction in Biology Yale Univ. 1977 E.J. Boell Award (Biology) Yale Univ. 1977 J.S. Nicholas Award (Zoology) Yale Univ. 1981 Alberta Heritage Scholar AHFMR 1985-1990 Outstanding Teacher Award Univ. Alberta 1990 “Hottest” Science (Science, 275, 1573, 1997) 1995-1996 Ashland Public School System Hall of Fame Ashland, MA 1998 ISI apoptosis (ranked in top 6 laboratories for total 1991-2001 citations, total publications, and citations per publication) MERIT Award, NIGMS 2002 ISI “highly cited” (Immunology) 2003 International Cell Death Society Prize 2009 Honorary Fellow Trinity College, Dublin 2010 Einstein Professorship China 2011 ISI “highly cited” (Molecular Biology/Genetics) 2014 Honorary Ph.D., Univ. Tor Vergata, Rome 2016 Jurg Tschopp Prize for Cell Death Research 2017 NCI Outstanding Investigator Award 2018 Most Cited Scientists of All Time (Google Scholar, currently 135)
Special Lectures:
Dalmer Lecture, Univ. Brit. Col. 1997 Hume Lecture, Am. Soc. Transpl. Surg. Chicago 1997 State of the Art Lecture, Amer. Soc. Nephrology, Boston 1999 Keynote Address, Keystone Symp. on Mol. Mechs. of Apoptosis 2001 Keynote Address, Gordon Res. Conf. on Cell Death 2001 Keynote Address, International Cytokine Society 2001 Keynote Address, Cancer Biology Retreat, MD Anderson 2002 Chair and Speaker, Major Symposium AAI 2002 Chair and Speaker, Major Symposium ASBMB 2002 BMRC Distinguished Visitor, Singapore 2003 AACR Annual Meeting, “Meet the Expert” 2004 AACR Annual Meeting, “Meet the Expert” 2005 Falk Memorial Lecture, NIEHS 2006 Ishizaka Lecture, LIAI, San Diego 2007 Hans Popper State of the Art Lecture, AASLD, Boston 2007 State of the Art Lecture, Amer. Coll. Rheumatol., Boston 2007 Giacchino Lecture, Thomas Jefferson Univ. 2008 Keynote Address, Apoptosis 2008, Luxembourg 2008 Keynote Lecture, International Worshop on p63/p73 2009 AACR Annual Meeting, “Meet the Expert” 2009 Lewis Thomas Lecture, NYU 2009 Gershon Lecture, Yale Univ. 2009 Keynote Lecture, MCRC Conference, Manchester, UK 2010 Keynote Lecture, Signaling 2000, Rio de Janeiro 2010 AACR Annual Meeting, “Meet the Expert” 2010 Keynote Lecture, FASEB Biology of Calpains 2010 Hamilton Lecture, Temple Univ. Sch. Med., Philadelphia 2012 Keynote Lecture, Int. Congress Cell Biol., Rio de Janeiro 2012 Keynote Lecture, Keystone Meeting on Immune Plasticity 2013 Keynote Lecture, Keystone Meeting on Autophagy 2013 Keynote Lecture, FASEB Meeting on Mitochondria 2013 Keynote Lecture, GRS Meeting on Clearance of Dying Cells 2013 Susan Cooper Jones Memorial Lecture, Huntsman Cancer Ctr. 2013 Keynote Speaker, Lupus Research Institute Annual Meeting 2013 Keynote Lecture, EACR Cell Death in Cancer, Amsterdam 2014 Keynote Lecture, Challenges & Sol. in Cancer, Rio de Janeiro. 2014 Johnson-Sokatch Lecture, Univ. Oklahoma 2014 NIH Immunology Retreat “guru” 2015 Keynote Speaker, EMBO Autophagy Meeting, Sardinia 2015 Eberly Lecture, Univ. Pittsburg 2016 Keynote Lecture, GRC Cell Death 2016 Keynote Lecture, Cell/Ipsen meeting on Cell Fate 2016 Keynote Lecture, EMBO cell death and inflammation, Innsbruck 2017 Keynote Lecture, Genes and Cancer, Cambridge, UK 2017 Sidney Lefkowitz Memorial Lecture, Tufts, Boston 2017 Keynote Lecture, Keystone Cell Death 2017 Keynote Lecture, European Cell Death Organization 2017 Keynote Lecture, Keystone Cell Death 2018 Ray Tubbs Memorial Keynote Lecture, Tucson Symposium 2018 Hollenberg Memorial Lecture, Univ. Manitoba Cancer Ctr. 2018
Employment:
2016-present Cancer Center Program Co-Director, Cancer Cell Biology, St. Jude Children’s Research Hospital, Memphis, TN 2005-Present Peter C. Doherty Endowed Chair of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 1994-2005 Adjunct Professor, Dept. Biology, University of California, San Diego 1990-2005 Member and Head, Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA. 1991-1993 Adjunct Professor, Dept. Immunology, Univ. Alberta, Edmonton, Alberta 1989-1991 Tenured (University Position), Dept. Immunology, Univ. Alberta, Edmonton, Alberta. 1987-1991 Associate Professor, Dept. Immunology, Univ. Alberta, Edmonton, Alberta. 1985-1987 Assistant Professor, Dept. Immunology, Univ. Alberta, Edmonton, Alberta. 1984-1985 Associate Research Biologist (nontenure faculty), Dept. of Biology, Yale University 1983-1984 Research Associate, Departments of Pathology and Surgery, Yale University. 1983-1984 Acting Co-Director, Laboratory of Dr. R.K. Gershon, Dept. Pathology, Yale University. 1982 Academic Fellow, Yale College. 1981 Academic Fellow, Yale College. 1981-1983 Post-Doctoral Fellow, Dept. Pathology, Yale University.
Societies:
American Association of Immunologists American Association for Cancer Research
Professional Activities
Study Sections: NIH Ad Hoc CMIB, SDSC, CAMP, SEP 2012, 2014, 2015, 2016 NIH (CMIB, Chair) 2007-2009 NIH (PathC, renamed CAMP) 2001-2005 NIH-NCI Site Visit 1995, 1998 NIH (IMB, Ad hoc) 1995, 1997 ACS (Cell Biology) 1994 NIH-NEI (Vis C, Ad hoc) 1994 MRC Site Visit 1992 NIH Site Visit (MBRS Program) 1991
Grants Panels (CANADA): AHFMR Fellowship Panel 1987 NCIC Grants Panel A 1988-1991 CARS Manpower Panel 1989
Canada Research Chair, College Member 2000-
Organizing Committees:
Intl. Congr. Immune Consequences of Shock, Trauma and Sepsis, Munich, W. Germany 1988, 1991, 1994, 1997 19th Intl. Leukocyte Culture Conference 1988 Workshop on Immune Tolerance and Suppression 1993, 1995, 1997 IBC Meeting on Apoptosis 1995 Vice-chair, Gordon Conf. on Cell Death 1997 AACR Apoptotis Symposium 1998 AACR Annual Meeting 1998, 1999, 2002, 2005, 2012, 2013 Chair, Gordon Conf. on Cell Death 1999 Co-chair, Keystone Conf. on Apoptosis 2001 ASBMB Annual Meeting 2002 SASS Fdn Workshop on Apoptosis and Infection 2002 TNF Superfamily Conference 2002 International Congress of Immunology 2004 Chair, Keystone Conf., Cell Death and Senescence 2005 Chair, Keystone Conf., Cell Death in the Immune System 2008 AACR Annual Meeting, Co-chair Program Comm. 2008 AACR Annual Meeting, Co-chair Program Comm. 2009 CSHL Cell Death Meeting, co-chair 2011 Co-Chair, Keystone Conf., Metabolism and inflammation 2013 Chair, CSHL Cell Death Meeting 2013 AACR Annual Meeting, Co-chair program comm. 2014 Co-Chair, Keystone Conf., Cell Death Signaling, Brazil 2014 CSHL Cell Death Meeting, co-chair 2015 CSHL Asia, Cell Death Meeting, co-chair 2015 NCI Cell Death Workshop, Chair 2015 Nature, Inflammatory Disease, Beijing, Org. comm. 2017
Journals: Editor in Chief, Oncogene 2009-2016 US Editorial Office, Cell Death Diff. 1994-2009 Senior Editor, Cancer Research 2002-2005 Senior Editor, Molecular Cancer Research 2006-2009 Associate Editor, Immunological Reviews 2002-2006 Associate Editor, Cytokine 1989-2015 Associate Editor, J. Exp. Zool. 1989-2002 Associate Editor, J. Clin. Immunol. 1996-Present Associate Editor, J. Biol. Chem. 1997-2001 Editorial Board, DNA Cell Biol. 1998-Present Editorial Board, Molecular Cell 1998-Present Editorial Board, Neoplasia 1998-Present Editorial Board, Cancer Cell 2002-Present Editorial Board, BMC Immunology 2004-Present Transmitting Editor, International Immunology 2001-2005 Editorial Board, Mol. Cell Biol. 2007-Present Editorial Board, J. Cell Sci. 2007-Present Editorial Board, Autophagy 2007-Present Editorial Board, Cell 2008-Present
Regular reviewer for the following journals: Cell, Molecular Cell, Developmental Cell, Cancer Cell, Neuron, Immunity, Nature, Nature Cell Biology, Nature Immunology, Science, J. Cell Biol., J. Exp. Med., J. Biol. Chem., PNAS, Cell Death Diff.
Chairman Search Committee, Immunology, Univ. Alberta 1988 Director Search Committee, La Jolla Inst. Allergy Immunol. 1993-1994 Faculty Search Committee, La Jolla Inst. Allergy Immunol. 1995-1998, 2002-2005 Chair Search Committee, St. Jude Children’s Research Hospital Dept. of Bone Marrow Transplantation, Cellular Therapy 2015-Present
Institutional Animal Care Committee Univ. Alberta 1989-1990 Chairman, Animal Care Committee LIAI 1990-1997
Scientific Advisory Boards: Maxim Pharmaceuticals San Diego, CA 2002-2005 Cytovia Pharmaceuticals (Chair) San Diego, CA 1999-2002 Eirx Pharmaceuticals Cork, Ireland 2001-2002 Keystone Symposia Keystone, CO 2005-2012 Lycera Ann Arbor, MI 2008-2010 Aeleron Boston, MA 2009-2010 Abramson Institute, Univ. Penn. Philadelphia, PA 2011-Present Spiral Therapeutics San Diego, CA 2017-Present
Awards and Contracts
Alberta Heritage Found. for Establishment Grant 1985 Medical Research
SciCan Diagnostic (grant) Lymphocyte Separation 1986
Central Res. Fund, Univ. Burns and Immunity 1986 Alberta
Canadian Found. Illeitis and Bacterial Sepsis and 1987-89 Colitis Immunity
Med. Res. Council of Antigen-specific T cell 1987-89 Canada factors
Arthritis Soc. Canada T Cell Response to 1987-89 Collagen II (with A. Fotedar, coPI)
Med. Res. Council of Inhibitory Lymphokines in 1989-1992 Canada Thermal Trauma
Med. Res. Council of Antigen-specific T Cell 1989-90 Canada Factors
MS Soc. Canada Regulation of EAE (with A. 1989-91 Salmi, coPI)
Arthritis Soc. Canada T Cell Response to 1989-91 Collagen II (with A. Fotedar, coPI)
Ortho Biotech (Contract) Trauma Induced 1989-90 Suppressive Cytokine
Med. Res. Council of Antigen Specific T Cell 1990-1992 Canada Factors
Natl. Cancer Inst. Canada Activation-Induced Cell 1990-1992 Death in the Immune System
US Natl. Inst. Health Stress-Induced Apoptosis in 1991-2012 (MERIT award, (R01GM52735, formerly T Cells 2002) R01AI31591)
Amer. Cancer Soc. (CB-82) Oncogene Interactions in 1993-1998 Apoptosis US Natl. Inst. Health Mechanisms of Bcl-2 1996-2010 (P01CA69381) family function in apoptosis (Comp. IV of Signal J. Reed, PI Transduction and Apoptosis)
US Natl. Inst. Health p53, Apoptosis and Chronic 1997-2000 (P60AR40770) Rheumatoid Arthritis
US Natl. Inst. Health LC3-associated 1997-2018 (R01AI40646) phagocytosis
Originally: Central Mechanisms of Apoptosis in the Immune System
US Natl. Inst. Health Survival function of the 1999-2022 (R01AI44828) FADD-caspase-8-FLIP complex
Originally: Activation- induced cell death in T lymphocytes
Pfizer Pharmaceuticals Fas-FasL interactions in 1999-2001 (contract) neurodegeneration
US Natl. Inst. Health Activation and function of 2000-2015 (R01AI47891) caspase-2
Leukemia Lymphoma Soc. A Novel Mechanism of p53 2004-2009 (SCOR-T. Mak, PI) Mediated Tumor Suppression
US Natl. Inst. Health Immune Tolerance 2004-2006 (R21AI059850) Induction by Apoptotic Bodies
US Natl. Inst. Health BCL-2 family interactions 2010-2019 R01-GM096208 in apoptosis.
US Natl. Inst. Health To the edge of necroptosis 2012-2022 R01-CA169291 and back. Originally: RIPK- dependent necrosis in development and cancer
Lupus Research Institute Non-canonical autophagy, 2015-2019 Distinuished Innovator phagocytosis, and SLE
Lupus Research Institute Supplement to above 2016-2018 Supplement Douglas R. Green PUBLICATIONS
1. Gershon, R. K., Eardley, D. D., Green, D. R., Shen, F. W., Yamauchi, K., Cantor, H., and Murphy, D. B. Contrasuppression: A novel immunoregulatory activity. J. Exp. Med. 153:1533-1546, 1981.
2. Green, D.R., Gershon, R.K. and Eardley, D.D. Ly-2 suppressor T lymphocytes directly inactivate different functional subsets of Ly-1 T cells. Proc. Natl. Acad. Sci. (USA) 78:3819-3823, 1981.
3. Green, D.R. and Eardley, D.D. Modeling a continuum of immune responsiveness. In: Immunoglobulin Idiotypes and Their Expression, edited by Janeway, C.A., Sercarz, E.E., Wigzell, H. and Fox, C.F. New York: Academic Press, 1981, p. 673-686.
4. Green, D.R., Eardley, D.D., Kimura, A., Murphy, D.B., Yamauchi, K. and Gershon, R.K. Immunoregulatory circuits that modulate responsiveness to suppressor cell signals: Identification of the effector cell of the contrasuppressor circuit. Eur. J. Immunol. 11:973-980, 1981.
5. Green, D.R. and Gershon, R.K. The immunologic orchestra. In: Immunoglobulin Idiotypes and Their Expression, edited by Janeway, C.A., Sercarz, E.E., Wigzell, H. and Fox, C.F. New York: Academic Press, 1981, p. 893-896.
6. Janeway, C. A., Broughton, B., Dzierzak, E., Jones, B., Eardley, D. D., Durum, S. K., Yamauchi, K., Green, D. R., and Gershon, R. K. Studies of T lymphocyte function in B cell deprived mice. In: Immunoglobulin Idiotypes and Their Expression, edited by Janeway, C.A., Sercarz, E.E., Wigzell, H. and Fox, C.F. New York: Academic Press, 1981, p. 661-671.
7. Kupper, T.S., Green, D.R., Chaudry, I.H., Clemens, M.G. and Baue, A.E. Restoration of the depressed immune response after burn injury with low dose cyclophosphamide. Surgical Forum 32:60-61, 1981.
8. Ptak, W., Green, D.R., Durum, S.K., Kimura, A., Murphy, D.B. and Gershon, R.K. Immunoregulatory circuits that modulate responsiveness to suppressor cell signals: Contrasuppressor cells can convert an in vivo tolerogenic signal into an immunogenic one. Eur. J. Immunol. 11:980-983, 1981.
9. Yamauchi, K., Eardley, D.D., Green, D.R., Murphy, D.B. and Gershon, R.K. Immunoregulatory circuits which modulate responsiveness to suppressor cell signals: The failure of B10 mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit. J. Exp. Med. 153:1547-1561, 1981.
10. Fox, A.D., Chaudry, I.H., Kupper, T.S., Green, D.R., Clemens, M.G. and Baue, A.E. Restoration of the depressed immune response following burn injury by administration of ATP-MgCl2 or tuftsin. Surgical Forum 33:69-71, 1982.
11. Green, D.R. and Gershon, R.K. Hyperimmunity and the decision to be intolerant. Ann.N.Y.Acad.Sci. 392:318-329, 1982.
12. Green, D.R. and St. Martin, S. Suppression and contrasuppression in the regulation of gut associated immune responses. Ann.N.Y.Acad.Sci. 409:284-291, 1982.
13. Green, D.R., Gold, J.A., St. Martin, S., Gershon, R. and Gershon, R.K. Microenvironmental immunoregulation: The possible role of contrasuppressor cells in maintaining immune responses in gut associated lymphoid tissue (GALT). Proc. Natl. Acad. Sci. (USA) 79:889-892, 1982.
14. Green, D.R. Contrasuppression: Its role in immunoregulation. In: The Potential Role of T Cell Subpopulations in Cancer Therapy, edited by Fefer, A. and Goldstein, A.L. New York: Raven Press, 1982, p. 279-290.
15. Smith, H.R., Green, D.R., Raveche, E.S., Smathers, P.A.,, Gershon, R.K. and Steinberg, A.D. Studies of the induction of anti-DNA in normal mice. J. Immunol. 129:2332-2334, 1982.
16. Yamauchi, K., Tanaguchi, M., Green, D.R. and Gershon, R.K. The use of a monoclonal anti-I-J antibody to distinguish cells in the feedback suppression circuit from those in the contrasuppressor circuit. Immunogenetics 16:551-558, 1982.
17. Green, D.R. and Gershon, R.K. Contrasuppression, Class I antigens, and cancer immunity. In: Haematology and Blood Transfusion V. 28, Trends in Human Leukemia, V, edited by Neth,, Gallo, R.,, Greaves, M.,, Moore, and Winkler. New York: Springer-Verlag, 1983, p. 479-485.
18. Green, D.R. and Gershon, R.K. A view from the bridge: Antigenic determinants in immunoregulation. In: Protein Conformation as an Immunological Signal, edited by Celada, F.,, Schumacher, V., and Sercarz, E. New York: Plenum Press, 1983, p. 387-394.
19. Green, D.R., Flood, P.M. and Gershon, R.K. Immunoregulatory T cell circuits. Ann. Rev. Immunol. 1:439-463, 1983.
20. Green, D.R. Immunoregulation by contrasuppressor T cells. EOS Riv. Immunol. Immunofarm. 3:155-161, 1983.
21. Green, D.R., Chue, B. and Gershon, R.K. Two types of T cell suppression discriminated by cell surface phenotype and by function: The ability to regulate the generation of contrasuppression. J. Mol. Cell. Immunol. 1:19-28, 1983.
22. Iverson, G.M., Ptak, W., Green, D.R. and Gershon, R.K. The role of contrasuppression in the adoptive transfer of immunity. J. Exp. Med. 158:982-987, 1983.
23. Smith, H.R., Green, D.R., Raveche, E.S., Smathers, P.A., Gershon, R.K. and Steinberg, A.D. Induction of autoimmunity in normal mice by thymectomy and administration of polyclonal B cell precursors: Association with contrasuppressor function. Clin. Exp. Immunol. 51:579-586, 1983.
24. Flood, P.M., Gershon, R.K. and Green, D.R. Information transfer between T cell sets. I-J+ molecules which act as carriers for regulatory signals. Prog. Immunol. 5:567-580, 1984.
25. Fusi, S., Kupper, T.S., Green, D.R. and Aryan, S. Reversal of post-burn immunosuppression by the administration of Vitamin A. Surgery 96:330-335, 1984.
26. Green, D.R. and Sercarz, E.E. Workshop summary: Immune networks and circuits. In: Regulation of the Immune System, edited by Cantor, H., Chess, L. and Sercarz, E.E. New York: Alan R. Liss, Inc., 1984, p. 801-805.
27. Green, D.R. The stratified structure of immune regulation. In: Regulation of the Immune System, edited by Cantor, H., Chess, L. and Sercarz, E.E. New York: Alan R. Liss, Inc., 1984, p. 735-745.
28. Green, D.R., Horowitz, M., Ferguson, T.A., Chue, B. and Flood, P.M. Immunoregulatory T cell pathways: The helper T cell clone as target. Asian Pac. J. Alergy Immunol. 2:318-324, 1984.
29. Green, D.R. and Gershon, R.K. Contrasuppression: The second law of thymodynamics, revisited. Adv. Cancer Res. 42:277-335, 1984.
30. Green, D.R. T8+ augmenting cells: Contrasuppression in man?. J. Mol. Cell. Immunol. 1:111-113, 1984.
31. Kupper, T.S. and Green, D.R. Immunoregulation after thermal injury: Sequential appearance of I- J+,Ly-1+,2- T suppressor-inducer cells and Ly-1-,2+ T suppressor-effector cells following thermal trauma in mice. J. Immunol. 133:3047-3053, 1984.
32. Kupper, T.S., Green, D.R., Chaudry, I.H., Fox, A.D. and Baue, A.E. A cyclophosphamide sensitive suppressor T cell circuit following thermal trauma. Surgery 95:699-706, 1984.
33. Ptak, W., Bereta, M., Ptak, M., Gershon, R.K. and Green, D.R. Regulatory T cell interactions with an antigen-specific T contrasuppressor factor in contact sensitivity: Eradication of the tolerant state. J. Immunol. 133:1124-1130, 1984.
34. Ptak, W., Bereta, M., Ptak, M., Gershon, R.K. and Green, D.R. Production of antigen-specific contrasuppressor cells and factor and their use in augmentation of cell mediated immunity. J. Immunol. 133:623-628, 1984.
35. Van Lovern, H., Kato, K., Meade, R., Green, D. R., Horowitz, M., Ptak, W., and Askenase, P. W. Characterization of two different Ly-1+ T cell populations that mediate delayed-type hypersensitivity. J. Immunol. 133:2402-2411, 1984.
36. Buss, L.W. and Green, D.R. Histocompatibility in vertebrates: The relict hypothesis. Dev. Comp. Immunol. 9:191-202, 1985.
37. Buss, L.W., Moore, J.L. and Green, D.R. Autoreactivity and self tolerance in an invertebrate. Nature 313:400-402, 1985.
38. Flood, P.M., Chue, B. and Green, D.R. Control of immune responsiveness by regulatory T lymphocytes. In: Concepts in Immunopathology, Vol. 3, edited by Cruise, J.M. and Lewis, R.E. Basel: Karger Press, 1985, p. 17-37.
39. Green, D.R., Chue, B., Ferguson, T.A., Beaman, K.D. and Flood, P.M. Production of an antigen- specific component of suppressor inducer factor by a helper T cell clone: Possible role of IL-1 at the interface of immunity and tolerance. Br. J. Rheumatol. 24 (Suppl. 1), 105-111, 1985.
40. Kupper, T.S. and Green, D.R. In vivo exposure to IL-1 or ETAF causes a loss in antigen-presenting cell function. Br. J. Rheumatol. 24 (Suppl. 1), 98-101, 1985.
41. Kupper, T.S., Green, D.R., Durum, S.K. and Baker, C.C. Defective antigen presention to a cloned T helper cell by macrophages from burned mice can be restored with interleukin-1. Surgery 98, 199-206, 1985.
42. Kupper, T.S., Baker, C.C., Ferguson, T.A. and Green, D.R. A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection. J. Surg. Res. 38, 606-612, 1985.
43. Ptak, W., Bereta, M., Iverson, G.M., Ptak, M. and Green, D.R. Suppression and contrasuppression in the induction of contact sensitivity by the administration of cell-bound antigen-antibody complexes. J. Immunol. 135, 2312-2318, 1985.
44. Flood, P.M., Ptak, W. and Green, D.R. Mechanism of action of a T suppressor factor in contact sensitivity: Characterization of the T cell target for TsF activity in adoptive transfer of immunity. J. Immunol. 137, 1829-1835, 1986.
45. Green, D.R. and Ptak, W. Suppressor and contrasuppressor T cell circuits and their relevance to diabetes. In: The Immunology of Diabetes Mellitus, edited by Jawarski, M.A., Molnar, G.D., Rajotte, R.F. and Singh, B. Amsterdam: Excerpta Medica, 1986, p. 411-416.
46. Green, D.R. Contrasuppressor T cells: A practical guide to the identification of contrasuppressive effects in immunoregulatory systems. In: Handbook of Experimental Immunology, edited by Herzenberg, L.A. and Weir, D.M. Oxford: Blackwell Scientific, 1986, p. 1-9.
47. Green, D.R. and Ptak, W. Contrasuppression, an immunoregulatory T cell activity. I. In the mouse. Immunol. Today 7, 81-86, 1986.
48. Ptak, W., Green, D.R. and Flood, P.M. Cellular interactions in the adoptive transfer of contact sensitivity: Characterization of an antigen nonspecific, Vicia villosa adherent T cell needed for adoptive transfer into naive recipients. J. Immunol. 137, 1822-1828, 1986.
49. Suzuki, I., Kitamura, K., Kiyono, H., Kurita, T., Green, D.R. and McGhee, J.R. Isotype-specific immunoregulation. Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine Peyer's patches. J. Exp. Med. 164, 501-516, 1986.
50. Suzuki, I., Kiyono, H., Kitamura, K., Green, D.R. and McGhee, J.R. Abrogation of oral tolerance by contrasuppressor T cells suggests the presence of regulatory T cell networks in the mucosal immune system. Nature 320, 451-454, 1986.
51. Chaouat, G., Kolb, J-P., Chaffaux, S., Riviere, M., Athanassakis, I., Green, D. R., and Wegmann, T. G. The placenta and the survival of the fetal allograft. In: Immunoregulation and Fetal Survival, edited by Gill, T.J. and Wegmann, T.G. New York: Oxford University Press, 1987, p. 239-251.
52. Eldridge, J. H., Kiyono, H., Suzuki, I., Kitamura, K., Kurita, T., Beagley, K. W., Michalek, S. M., Green, D. R. and McGhee, J. R. Regulatory T cell networks in the secretory immune system. In: Mucosal Immunology, edited by Mestecky, J., McGhee, J.R., Bienenstock, J. and Ogra, P. New York: Plenum Press, 1987, p. 45-55.
53. Green, D.R., Chue, B., Zheng, H., Ferguson, T.A., Beaman, K.D. and Flood, P.M. A helper T cell clone produces an antigen-specific molecule (TABM) which functions in the induction of suppression. J. Mol. Cell. Immunol. 3, 95-108, 1987.
54. Green, D.R., Zheng, H. and Wang, N. A T suppressor inducer factor from burn associated T cells. J. Burn Care Rehab. 8, 521-526, 1987.
55. Green, D.R., Marcotte, R., Wang, N. and Zheng, H. Immunoregulatory T cells and immunodeficiency. In: Immunology and Oncology of Down's Syndrome, edited by McCoy, E.E. and Epstein, C. New York: Raven Press, 1987, p. 183-190.
56. Green, D.R. and Wegmann, T.G. Beyond the immune system: The immunotrophic role of T cells in organ generation and regeneration. Prog. Immunol. 6, 1100-1112, 1987.
57. Kitamura, K., Kiyono, H., Eldridge, J.H., Green, D.R. and McGhee, J.R. Effector contrasuppressor T cells which abrogate oral tolerance are distinct from both helper (L3T4+) and suppressor (Ly-2+) T cells. J. Immunol. 139, 3251-3259, 1987.
58. Kitamura, K., Suzuki, I., Kiyono, H., Kurita, T., Berry, A. K., Green, D. R., and McGhee, J. R. Isotype specific immunoregulation: T contrasuppressor cells protect IgA responses in oral tolerance. In: Mucosal Immunology, edited by Mestecky, J., McGhee, J.R., Bienenstock, J. and Ogra, P. New York: Plenum Press, 1987, p. 143-148.
59. Mogil, R.J., Green, D.R. and Wegmann, T.G. Immunotrophism at the maternal-fetal interface. In: Immunologie de la Reproduction: Relation Materno-Foetale, edited by Chaouat, G. Paris: INSERM, 1987, p. 113-120.
60. Mogil, R.J., Patton, C.L. and Green, D.R. Cellular subsets involved in cell-mediated immunity to murine Plasmodium yoelii 17X malaria. J. Immunol. 138, 1933-1939, 1987.
61. Cone, R.E., Zheng, H., Chue, B., Beaman, K., Ferguson, T. and Green, D.R. T cell-derived antigen binding molecules (TABM): Molecular and functional properties. Intern. Rev. Immunol. 3, 205- 228, 1988.
62. Green, D.R., McGhee, J.R. and Ptak, W. Contrasuppression and the control of microenvironmental immune responses. In: Mucosal Immunobiology, edited by Hanson, L. Basel: Karger Press, 1988, pp. 236-243.
63. Green, D.R., Chue, B. and Flood, P.M. The induction of contrasuppression is restricted by genes mapping to the Igh locus. Immunol. Res. 7, 82-92, 1988.
64. Green, D.R. Regulatory T cell function, antigen recognition, and an immunological decision point. In: The Semiotics of Cellular Communication in the Immune System, edited by Sercarz, E.E., Celada, F., Mitchison, N.A. and Tada, T. Berlin: Springer-Verlag, 1988, p. 245-256.
65. Kiyono, H., Green, D.R. and McGhee, J.R. Contrasuppression in the mucosal immune system. Immunol. Res. 7, 67-81, 1988.
66. Mogil, R.J., Patton, C.L. and Green, D.R. An immunogenic antigen of murine Plasmodium yoelii 17X associates with Class I MHC glycoproteins. J. Immunol. 141, 258-264, 1988.
67. Ptak, W., Friedman, A., Bereta, M., Marcinkiewicz, J., Horvat, B, Reuter P, Green, D.R., and Flood, P.M. The role of contrasuppressor T cells in the adoptive transfer of contact sensitivity responses to picryl chloride. Immunol. Res. 7, 1-11, 1988.
68. Ptak, W., Janeway, C.A., Flood, P.M., Marcinkiewicz, J. and Green, D.R. Immunoregulatory effects of cell-bound antigen-antibody complexes: Requirements for the induction of hapten- specific T contrasuppressor cells. J. Immunol. 141, 756-764, 1988.
69. Wegmann, T.G., Fotedar, A. and Green, D.R. Immunotrophism and fetal survival. In: Perspectives in Immunoreproduction, edited by Mathur, S. and Fredericks, C.M. Washington: Hemisphere Pub. Co., 1988, p. 359-387.
70. Zheng, H., Boyer, M., Fotedar, A., Singh, B. and Green, D.R. An antigen-specific helper T cell hybridoma produces an antigen-specific suppressor-inducer molecule: Implications for the antigen recognition and function of helper and suppressor-inducer T cells. J. Immunol. 140, 1351-1358, 1988.
71. Green, D.R., and Faist, E. Trauma and the immune response. Immunol. Today, 9, 253-256, 1988.
72. Chue, B., Beaman, K.D., Rosenman, S.J., Cone, R.E., Flood, P.M. and Green, D.R. An approach to the unification of suppressor T cell circuits. A simplified assay for the induction of suppression by T-cell derived, antigen binding molecules (TABM). Cell. Immunol. 118, 30-40, 1989.
73. Friedman, A.M., Ptak, W., Freedman, J., Green, D.R. and Flood, P.M. Prevention of tumor growth and enhancement of cell-mediated immunity by an antigen-specific contrasuppressor factor from a T cell hybridoma. In: Immunity to Cancer. II, edited by Mitchell, M.S. New York: Alan R. Liss, 1989, p. 281-288.
74. Green, D.R., Marcotte, R. and Wang, N. The role of inhibitory T cells in burn trauma-associated immunodeficiency. In: The Immune Consequences of Shock, Trauma, and Sepsis, edited by Faist, E., Ninnemann, J.N. and Green, D.R., Springer-Verlag, Berlin, 1989, pp. 55-62.
75. Green, D.R., Friedman, A., Ptak, W., McGhee, J.R. and Flood, P.M. Contrasuppression, tolerance, and tumor immunity. In: Immunity to Cancer. II, edited by Mitchell, M.S. New York: Alan R. Liss, 1989, p. 245-258.
76. Sadelain, M.W.J., Voralia, M., Green, D.R. and Wegmann, T.G. The role of natural suppressor and natural killer activities in resistance to hemopoietic transplantation in unirradiated hosts. J. Immunol. 1989, 142, 2270-2278.
77. Sadelain, M.W.J., Voralia, M., Green, D.R. and Wegmann, T.G. Mechanisms that determine host resistance to bone marrow stem cell engraftment in unirradiated hosts. In: Cellular Basis of Immune Modulation, edited by Kaplan, J.G., Green, D.R. and Bleakley, R.C. New York: Alan R. Liss, Inc., 1989, p. 229-235.
78. Sahai, B.M., Serra, H.M., Green, D.R. and Kaplan, J.G. Interleukin 2-induced Tac gene expression and proliferation in resting human T lymphocytes are monocyte dependent. In: Cellular Basis of Immune Modulation, edited by Kaplan, J.G., Green, D.R. and Bleakley, R.C. New York: Alan R. Liss, 1989, p. 283-288.
79. Zheng, H., Fotedar, A., Singh, B. and Green, D.R. An antigen-specific immunoregulatory activity from a helper T cell hybridoma: Possible relationship to the T cell receptor. In: Cellular Basis of Immune Modulation, edited by Kaplan, J.G., Green, D.R. and Bleakley, R.C. New York: Alan R. Liss, Inc., 1989, p. 379-382.
80. Zheng, H., Sahai, B.M., Kilgannon, P., Fotedar, A. and Green, D.R. Specific inhibition of cell- surface T cell receptor expression by antisense oligonucleotides and its effect on the production of an antigen-specific regulatory T cell factor. Proc. Natl. Acad. Sci. (USA) , 86, 3758-3762, 1989.
81. Shi, Y., Sahai, B.M., and Green, D.R. Cyclosporin A inhibits activation-induced cell death in T cell hybridomas and in thymocytes. Nature, 339, 625-626, 1989.
82. Green, D.R. and Zheng, H. Antigen-specific regulatory T cell factors and the T cell receptor. Ann. Inst. Pasteur, 140, 294-298, 1989.
83. Kiyono, H., Kohtaro, F., Green, D.R., and McGhee, J.R. The mucosal immune system: possible roles for contrasuppression in normal and abberant IgA responses. In: Molecular Aspects of Human Disease, edited by Gorrd, Albano, and Papa, Ellis Horwood LTD, W. Sussex, 1989, pp. 229-239.
84. Beagley, K.W., Fujihashi, K., Aicher, W., Xu, J., Kiyono, H., Eldridge, J.H., Bruce, M.G., Taguchi, T., Green, D.R., Singh, B., and McGhee, J.R. Mucosal homeostasis: Role of interleukins, isotype-specific factors, and contrasuppression in the IgA response. Immunol. Invest., 18, 77-89, 1989.
85. Friedman, A.M., Ptak, W., Freedman, J., Green, D.R., and Flood, P.M. Prevention of tumor growth and enhancement of cell-mediated immunity by an antigen-specific contrasuppressor factor from a T cell hybridoma. Prog. Clin. Biol. Res., 288, 282-288, 1989.
86. Fujihashi, K., Kiyono, H., Aicher, W.K., Green, D.R., Singh, B., Eldridge, J.H., and McGhee, J.R. Immunoregulatory function of CD3+, CD4-, and CD8- T cells: TCR-positive T cells from nude mice abrogate oral tolerance. J. Immunol., 143, 3415-3422, 1989.
87. Green, D.R., and Kaufman, J. The evolution of the MHC. In: Defense Molecules, edited by J.J. Marchalonis and C. Reinish, Alan Liss, New York, 1990, pp. 119-124.
88. Shi, Y., Szalay, M.G., Paskar, L., Sahai, B.M., Boyer, M., Singh, B., and Green, D.R. Activation- induced cell death in T cell hybridomas is due to apoptosis: Morphological aspects and DNA fragmentation. J. Immunol., 144, 3326-3333, 1990.
89. Sadelain, M.J., Green, D.R., and Wegmann, T.G. Host natural suppressor activity regulates hemopoietic engraftment in antibody conditioned recipient mice. J. Immunol., 144, 1729-1736, 1990.
90. Fujihashi, K, Taguchi, T., McGhee, J.R., Eldridge, J.H., Bruce, M.G., Green, D.R., Singh, B., and Kiyono, H. Regulatory function for murine intraepithelial lymphocytes: Two subsets of CD3+, T cell receptor - 1+ intraepithelial lymphocyte T cells abrogate oral tolerance. J. Immunol., 145, 2010- 1019, 1990.
91. Friedman, A.M., Ptak, W., Brewer, E., Green, D.R., Reuter, P.A., and Flood, P.M. Generation of a T cell hybridoma producing a contrasuppressor factor for contact sensitivity. Immunology, 71, 282-289, 1990.
92. Leddy, S.V., and Green, D.R. Historecognition in the Cnidaria. In: Phylogenesis of Immune Function, edited by G. Warr and N. Cohen, CRC Press, Boca Ratan, 1991, pp 103-116.
93. Green, D.R. and Shi, Y. Activation-induced cell death in developing T cells and T cell hybridomas. Adv. Struct. Biol. 1, 287-300, 1991.
94. Bissonnette, R., Zheng, H., Kubo, R., and Green, D.R. A helper T cell hybridoma produces an antigen-specific regulatory activity. Relationship to the T cell receptor by serology and antigenic fine-specificity. J. Immunol., 146, 2898-2907, 1991.
95. Shi, Y., Bissonnette, R.P., Parfrey, N., Szalay, M., Kubo, R.T., and Green, D.R. In vivo administration of antibodies to the CD3-T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J. Immunol. 146, 3340-3346, 1991.
96. Green, D.R., Bissonnette, R., Zheng, H., Onda, T., Echeverri, F., Mogil, R.J., Steele, J.K., Voralia, M., and Fotedar, A. Immunoregulatory activity of the T cell receptor chain demonstrated by retroviral gene transfer. Proc. Natl. Acad. Sci. (USA), 88, 8475-8479, 1991.
97. Cotter, T.G., Lennon, S., Glynn, J.M., and Green, D.R. Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer Res., 52, 997-1005, 1992.
98. Green, D.R., and Flood, P.M. Contrasuppression. In: Roitt, I.M. and Delves, P.J. (eds) The Encyclopedia of Immunology, Saunders Scientific Pub, London. pp. 300-303, 1992.
99. Green, D.R., Zheng, H., and Shi, Y. Antisense oligodeoxynucleotides as probes of T lymphocyte gene function. Ann. N.Y. Acad. Sci., 660, 193-203, 1992.
100. Cotter, T.G., Glynn, J.M., Echeverri, F. and Green, D.R. The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle. Anticancer Res., 12, 773-780, 1992.
101. Green, D.R. T lymphocytes. In: Lederberg, J. (ed). The Encyclopedia of Microbiology. Academic Press. 1992. pp. 243-253.
102. Shi, Y., Bissonnette, R.P., Glynn, J.M., Guilbert, L.J., Cotter, T.G., and Green, D.R. Inhibition of activation-induced apoptosis in T cells by antisense oligodeoxynucleotides corresponding to c-myc. Science 257, 212-214, 1992.
103. Bissonnette, R.P., Echeverri, F., Mahboubi, A., and Green, D.R. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature, 359, 552-554, 1992.
104. Green, D.R., and Cotter, T.G. Apoptosis in the immune system. Sem. Immunol., 4, 355-362, 1992.
105. Green, D.R., Bissonnette, R.P., Glynn, J.M., and Shi, Y. Activation-induced apoptosis in lymphoid systems. Sem. Immunol., 4, 379-388, 1992.
106. Richards, R., and Green, D.R. Local administration of interleukin-2 protects mice from lethal intra- abdominal bacterial sepsis. In: Faist, E. (ed) The Immune Consequences of Shock, Trauma, and Sepsis, 2nd Ed., Springer-Verlag, 1993, pp 1251-1256.
107. Green, D.R., and Webb, D.R. Saying the "S" word in public. Immunol. Today, 14, 523-525, 1993.
108. Helgason, C.D., Shi, L., Greenberg, A.H., Shi, Y., Bromley, P., Cotter, T.G., Green, D.R., and Bleackley, R.C. DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death. Exp. Cell Res. 206, 302-310, 1993.
109. Green, D.R., and Cotter, T.G. Macromolecular synthesis, c-myc, and apoptosis. In Lavin, M., and Watters, D. (eds.) Cell Death: The Cellular and Molecular Biology of Apoptosis, Gordon Breach, New York, pp 153-166, 1993.
110. Green, D.R. The Major Histocompatibility Complex. In: Sigal, L.H., Taffet, S.M., Gavalchin, J., and Humphrey, D.M. (eds). Immunology and Inflammation: Basic Mechanisms and Clinical Consequences McGraw-Hill, 1994, pp. 63-74.
111. Bissonnette, R.P., Shi, Y., Mahboubi, A., Glynn, J.M., and Green, D.R. C-myc and apoptosis. In Tomei, L.D., and Cope, F.O. (eds.) Apoptosis II: The Molecular Basis of Cell Death. Cold Spring Harbor Lab. Press, Cold Spring Harbor. pp. 327-356, 1994.
112. Green, D.R., Shi, Y., Glynn, J., Mahboubi, A., and Mogil, R.J. Myc, Fas, apoptosis, and immune tolerance. In Mihich, E., and Schimke, R.T. (eds.) Apoptosis, Plenum Press, New York. pp. 213- 222, 1994.
113. Martin, S.J., Green, D.R., and Cotter, T.G. Dicing with death: Dissecting the components of the apoptosis pathway. TIBS 19, 26-30, 1994.
114. Green, D.R., Bissonnette, R.P., and Cotter, T.G. Apoptosis and Cancer. In DeVita, M.D., Hellman, S., and Rosenberg, S.A. (eds.) Important Advances in Oncology, 1994. pp. 37-52. Also published as: Principles and Practice of Oncology Updates, Vol. 8, 1994.
115. Fischer, G., Kent, S.C., Joseph, L., Green, D.R., and Scott, D.W. Lymphoma models for B cell activation and tolerance. X. Anti--mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J. Exp. Med. 179, 221-228, 1994.
116. Mogil, R.J., Shi, Y., Bissonnette, R.P., Bromley, P., Yamaguchi, I., and Green, D.R. The role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo. J. Immunol. 152, 1674-1683, 1994.
117. McGahon, A., Bissonnette, R., Schmitt, M., Cotter, K.M., Martin, S.J., Green, D.R., and Cotter, T.G. (Shared Senior Authorship) BCR-ABL maintains resistance of chronic myelogenous leukaemia cells to apoptotic cell death. Blood, 83, 1179-1187, 1994.
118. Green, D.R., and Scott, D.W. Activation-induced apoptosis in lymphocytes. Curr. Opinion Immunol., 6, 476-487, 1994.
119. McGahon, A.J., Cotter, T.G., Green, D.R. The abl oncogene family and apoptosis. Cell Death Diff., 1: 77-83, 1994.
120. Bissonnette, R.P., McGahon, A., and Green, D.R. Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas. J. Exp. Med. 180, 2413-2418, 1994.
121. Martin, S.J., and Green, D.R. Apoptosis as a goal of cancer therapy. Curr. Opinion Oncol., 6, 616- 621, 1994.
122. Yousefi, S., Green, D.R., Blaser, K., and Simon, H.U. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc. Natl. Acad. Sci. USA 91, 10868-10872, 1994.
123. Green, D.R., Mahboubi, A., Nishioka, W., Oja, S., Echeverri, F., Shi, Y., Glynn, J., Ashwell, J., and Bissonnette, R. Promotion and inhibition of activation-induced apoptosis in T cell hybridomas by oncogenes and related signals. Immunol. Rev. 142, 321-342, 1994.
124. Martin, S.J., and Green, D.R. Apoptosis and cancer: The failure of controls on cell death and cell survival. Crit. Rev. Oncol. Hematol., 18, 137-153, 1995.
125. Onda, T., Messier H., Bissonnette, R., Echeverri, F., Baier, G., Fotedar, A., and Green, D.R. Immunoregulatory activity of a T cell receptor chain demonstrated by in vitro transcription and translation. Proc. Natl. Acad. Sci., 92, 3004-3008, 1995.
126. Martin, S.J., and Green, D.R. Apoptosis during HIV infection: a cytopathic effect of HIV or an important host-defense mechanism against viruses in general? In: Andrieu, J.M. and Lu, W. (eds.) Cell Activation and Apoptosis in HIV Infection, Plenum Press, 1995, pp. 129-138.
127. McGahon, A.J., Martin, S.J., Bissonnette, R.P., Mahboubi, A., Shi, Y., Mogil, R.J., and Green, D.R. The end of the (cell) line: Methods for the study of apoptosis in vitro. In Schwartz, L.M., and Osborne, B.A. (eds.) Cell Death.. Methods in Cell Biology, V. 46 Academic Press, Inc. 1995. pp153-185.
128. Wills, C. and Green, D.R. A herd-immunity model for the maintenance of MHC polymorphism. Immunol. Rev., 143, 263-292, 1995.
129. Brunner, T., Mogil, R.J., Mahboubi, A., LaFace, D., Yoo, N.J., Echeverri, F., Martin, S.J., Ware, C.F., and Green, D.R. Apoptosis induced by ligation of the T cell receptor on T cell hybridomas proceeds via a cell autonomous Fas (CD95)/Fas-ligand interaction. Nature 373, 441-444, 1995.
130. Martin, S.J., O'Brien, G.A., Nishioka, W.K., McGahon, A.J., Mahboubi, A., Saido, T.C., and Green, D.R. Proteolysis of fodrin (nonerythroid spectrin) during apoptosis. J. Biol. Chem. 270, 6425- 6428, 1995.
131. Gulbins, E., Bissonnette, R., Mahboubi, A., Martin, S., Nishioka, W., Brunner, T., Baier, G., Bitterlich-Baier, G., Byrd, C., Lang, F., Kolesnick, R., Altman, A., and Green, D.R. (Shared Senior Authorship) Fas-induced apoptosis is mediated by a ceramide-initiated Ras signaling pathway. Immunity, 2, 341-351, 1995.
132. Martin, S.J., McGahon, A.J., Nishioka, W.K., LaFace, D., Th'ng, J., Bradbury, E.M., and Green, D.R. P34cdc-2 and apoptosis. Science, 269, 106-107,1995.
133. Onda, T., Messier, H., Bissonnette, R., Echeverri, F., Baier, G., Fotedar, A., and Green, D.R. Antigen-specific immunoregulatory activity of a T cell receptor chain generated by expression PCR. Int. Arch. Allergy Immunol., 107, 356-358, 1995.
134. Shi, Y., Radvanyi, L.G., Sharma, A.J., Shaw, P., Green, D.R., Miller, R.G., and Mills, G.B. CD28- mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J. Immunol., 155, 1829-1837, 1995.
135. Mogil, R.J., Radvanyi, L., Gonzalez-Quintial, R., Miller, R., Mills, G., Theofilopoulos, A.N., and Green, D.R. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. International Immunology, 7, 1451-1458, 1995.
136. Martin, S.J., Takayama, S., McGahon, A.J., Miyashita, T., Corbeil, J., Kolesnick, R.N., Reed, J.C., and Green, D.R. Inhibition of ceramide-induced apoptosis by Bcl-2. Cell Death Diff., 2, 253-258, 1995.
137. Martin, S.J., and Green, D.R. Protease activation in apoptosis: Death by a thousand cuts? Cell, 82,349-352, 1995
138. Martin, S.J., Reutelingsperger, C.P.M., McGahon, A.J., Rader, J., van Schie, R.C.A.A., LaFace, D.M., and Green, D.R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med, 182, 1545-1556, 1995.
139. Martin, S.J., Newmeyer, D.D., Mathias, S., Farschon, D., Wang, H.G., Reed, J., Kolesnick, R.N., Green, D.R. Cell-free reconstitution of Fas-, UV radiation-, and ceramide-induced apoptosis. EMBO J., 14, 5191-5200, 1995.
140. Green, D.R., and Martin, S.J. The killer and the executioner: How apoptosis controls malignancy. Curr. Opin. Immunol., 7, 694-703, 1995.
141. Bissonnette, R.P., Brunner, T., Lazarchik, S.B., Yoo, N.J., Boehm, M.F., Green, D.R., and Heyman, R.A. (Shared Senior Authorship) 9-cis Retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of Fas-ligand and requires RAR and RXR activation. Mol. Cell Biol., 15, 5576-5585, 1995.
142. McGahon, A., Nishioka, W.K., Martin, S.J., Mahboubi, A., Cotter, T.G., and Green, D.R. Regulation of the Fas apoptotic cell death pathway by Abl. J. Biol. Chem., 270, 22625-22631, 1995.
143. Griffith, T.S., Brunner, T., Fletcher, S., Green, D.R., and Ferguson, T.A. Fas/Fas-ligand-induced apoptosis as a mechanism of immune privilege. Science, 270, 1189-1192, 1995.
144. Green, D.R., McGahon, A., and Martin, S.J. Regulation of apoptosis by oncogenes. J. Cellular Biochem., 60, 33-38, 1996.
145. Martin, S.J., Reutelingsperger, C.P.M., and Green, D.R. Annexin V-a specific probe for the detection of phosphatidylserine exposure on the outer plasma membrane leaflet during apoptosis. In Cotter, T.G. and Martin, S.J. (eds.) Techniques in Apoptosis: A Users Guide, Portland Press, London, 1996, pp. 107-121.
146. Martin, S.J., and Green, D.R. Cell free apoptosis. In Cotter, T.G. and Martin, S.J. (eds.) Techniques in Apoptosis: A Users Guide, Portland Press, London, 1996, pp. 121-132.
147. Green, D.R. Overview: Apoptosis. In Herzenzerg, L.A., and Weir, D.M. (eds.) Handbook of Experimental Immunology, 5th Edition. Blackwell Science, Cambridge, 1996. pp. 123.1-123.4.
148. Martin, S.J., and Green, D.R. Morphological features of apoptosis. In Herzenzerg, L.A., and Weir, D.M. (eds.) Handbook of Experimental Immunology, 5th Edition. Blackwell Science, Cambridge, 1996. pp. 124.1-124.5.
149. Onda, T., La Face, D. Baier, G., Brunner, T., Honma, N., Mikayama, T., Altman, A., and Green, D.R. A phage display system for binding and selection of direct antigen-binding T cell receptor molecules. Molecular Immunology, 32, 1387-1397, 1995.
150. Martin, S.J., Amarante-Mendes, G.P., Shi, L., Chuang, T.H., Casiano, C.A., Fitzgerald, P., Tan, E.M., Bokoch, G.M., Greenberg, A.H., and Green, D.R. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/ced-3- family protease, CPP32, via a novel two-step mechanism. EMBO J., 15, 2407-2416, 1996.
151. Skowronski, E.W., Kolesnick, R.N., and Green, D.R. Fas-mediated apoptosis and sphingomyelinase signal transduction: The role of ceramide as a second messenger for apoptosis. Cell Death Diff., 3, 171-176, 1996.
152. Brunner, T., Yoo, N.J., LaFace, D., Ware, C.F., and Green, D.R. Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. Int. Immunol., 8, 1017-1026, 1996.
153. Brunner, T., Yoo, N.J., Griffith, T.S., Ferguson, T.A., and Green, D.R. Regulation of CD95 expression: a key element in immune regulation? Behr. Inst. Mitt. 97, 161-174, 1996.
154. Santana, P., Pena, L.A., Haimovitz-Friedman, A., Martin, S., Green, D., McLaughlin, M., Cordon- Cardo, C., Schuchman, E.H., Fuks, Z., and Kolesnick, R. Acid sphingomyelinase deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell, 86, 189-200, 1996.
155. Casiano, C.A., Martin, S.J., Green, D.R., and Tan, E.M. Cleavage of a subset of nuclear autoantigens associated with different functions during CD95 (Fas/APO-1)-mediated T cell apoptosis. J. Exp. Med., 182, 765-770, 1996.
156. Martin, S.J., Amarante-Mendes, G.P., Green, D.R. Cytotoxic cell killing enters the ICE age. In, Gupta, S., (ed) Mechanisms of Lymphocyte Activation and Immune Regulation VI: Cell Cycle and Programmed Cell Death in the Immune System. Adv. Exp. Med. Biol ., 406, 29-37, 1996.
157. Griffith, T.S., Yu, X., Herndon, J.M., Green, D.R., and Ferguson, T.A. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity, 5, 7-17, 1996.
158. Meisenholder, G.W., Martin, S.J., Green, D.R., Nordberg, J., Babior, B.M., and Gottlieb, R.A. Events in apoptosis, Acidification is downstream of protease activation and Bcl-2 protection. J. Biol. Chem. 271, 16260-16267, 1996.
159. Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R., and Verma, I.M. NF-B activation by TNF suppresses signals for apoptosis. Science 274, 787-789, 1996.
160. Martin, S.J., Finucane, D.M., Amarante-Mendes, G.P., O'Brien, G.A., and Green, D.R. Phosphatidylserine externalization during CD95-induced apoptosis of both cells and cytoplasts requires ICE/CED-3 protease activity. J. Biol. Chem., 271, 28753-28756, 1996.
161. Green, D.R., and Martin, S.J. The ICE/Ced-3-family proteases as the apoptotic executioner. Cell Death Diff. 3, 339-340, 1996.
162. McGahon, A.J., Brown, D.G., Martin, S.J., Amarante-Mendes, G., Cotter, T.G., Cohen, G.M., Green, D.R. Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis. Characterization of the apoptotic death. Cell Death Diff., 4, 95-104, 1997.
163. Woodle, E.S., Smith, D.M., Bluestone, J.A., Kirkman, W.M., Green, D.R., and Skowronski, E.W. Anti-human class I MHC antibodies induce apoptosis by a pathway which is distinct from the Fas antigen-mediated pathway. J. Immunol., 158, 2156-2164, 1997.
164. Tan, X., Martin, S.J., Green, D.R., and Wang, J.Y.J. Degradation of RB at a consensus Ice/Ced-3 cleavage site during CD95-, TNF- and cisplatin-induced cell death. J. Biol. Chem., 272, 9613- 9616, 1997.
165. Kluck, R.M., Bossy-Wetzel, E., Green, D.R., and Newmeyer, D.D. (Shared Senior Authorship) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science, 275, 1132-1136, 1997.
166. Niehans, G.A., Brunner, T., Frizzelle, S.P., Liston, J.C., Salerno, C.T., Knapp, D.J., Green, D.R., and Kratzke, R.A. Human lung carcinomas express Fas ligand. Cancer Research, 57, 1007-1012, 1997.
167. Zhang, X., Brunner, T., Carter, L., Dutton, R.W., Sato, T., Reed, J., Green, D.R., and Swain, S.L. Unequal death in Th1 and Th2 effectors: Th1 but not Th2 effectors undergo rapid Fas/FasL- mediated apoptosis. J. Exp. Med., 185, 1837-1849, 1997.
168. Scott, D.W., Brunner, T., Donjerkovic´, D., Ezhevsky, S., Grdina, T., Green, D., Shi Y., and Yao, X.R. Murder and suicide: A tale of T and B cell apoptosis. In: Shi, Y-B., Shi, Y., Scott, D., and Xu, Y. (eds.), Current Advances in Programmed Cell Death, Plenum Publishing Corp., New York, 1997, pp.91-104.
169. Green, D.R., Tietz, B., Ferguson, T.A., and Brunner, T. Taking out the immune response: The roles of Fas-ligand (CD95L) in immune regulation. In: Shi, Y-B., Shi, Y., Scott, D., and Xu, Y. (eds.), Current Advances in Programmed Cell Death, Plenum Publishing Corp., New York, 1997, pp. 147-158.
170. Green, D.R., and Ware, C.F. Fas-ligand: Privilege and peril. Proc. Natl. Acad. Sci. USA, 94, 5986- 5990, 1997.
171. Amarante-Mendes, G.P., Jascur, T., Nishioka, W.K., Mustelin, T., and Green, D.R. Bcr-Abl- mediated resistance to apoptosis is independent of PI3-kinase activity. Cell Death Diff., 4, 548- 555, 1997.
172. Kluck, R.M., Martin, S.J., Hoffman, B.M., Zhou, J.S., Green, D.R., and Newmeyer, D.D. Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. EMBO J.,16, 4639-4649, 1997.
173. Ellerby, H.M., Martin, S.J., Ellerby, L.M., Naiem, S.S., Rabizadeh, S., Salveson, G.S., Casiano, C.A., Cashman, N.R., Green, D.R., and Bredesen, D.E. Establishment of a cell-free system of neuronal apoptosis: Comparison of pre-mitochondrial, mitochondrial, and post-mitochondrial phases. J. Neurosci., 17, 6165-6178, 1997.
174. Ayyavoo, V., Mahboubi, A., Williams, W.V., Mahalingam, S., Sagar, K., Green, D.R., and Weiner, W.B. HIV-1 Vpr suppresses immune activation and apoptosis through regulation with NF-kB. Nature Med., 3, 1117-1123, 1997.
175. Firestein, G.S., Echeverri, F., Yeo, M., Zvaifler, N.J., and Green, D.R. Somatic mutations in the p53 gene in rheumatoid arthritis synovium. Proc. Natl. Acad. Sci. USA, 94, 10895-10900, 1997.
176. Green, D.R. (Commentary) A myc-induced apoptosis pathway surfaces. Science 278, 1246-1247, 1997.
177. Broome, H.E., Dargan, C.M., Brunner, T., and Green, D.R. Sensitivity of S49.1 cells to anti-CD95 (Fas/Apo-1)-induced apoptosis. Effects of CD95, bcl-2 or bcl-x transduction. Cell Death Diff., 5, 200-205, 1998.
178. Amarante-Mendes, G.P., Brunner, T., Kasibhatla, S., Bossy-Wetzel, E., and Green, D.R. Apoptosis assays. In: D.L. Spector, R.D. Goldman, and L.A. Leinwand (eds)., Cells, A Laboratory Manual, CSH Press, Cold Spring Harbor. 1998. pp. 15.1-15.24.
179. Faris, M., Kokot, N., Latinis, K., Kasibhatla, S., Green, D.R., Koretzky, G.A., and Nel, A. MEKK1 induced apoptosis of Jurkat cells is mediated by Fas/FasL interaction. J. Immunol. 160, 134-144, 1998.
180. Bossy-Wetzel, E., Newmeyer, D.D., and Green, D.R. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 17, 37-49, 1998.
181. Amarante-Mendes, G.P., McGahon, A.J., Nishioka, W.K., Afar, D.E.H., Witte, O.N., and Green, D.R. Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with up regulation of Bcl-xL. Oncogene 16, 1383-1390, 1998.
182. Amarante-Mendes, G.P., Kim, C.N., Liu, L., Huang, Y., Perkins, C.L., Green, D.R., and Bhalla, K. BCR-ABL exerts its anti-apoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome c and activation of caspase-3. Blood 91, 1700-1705, 1998.
183. Amarante-Mendes, G.P., and Green, D.R. Abl tyrosine kinase and the control of apoptosis. In: S.J. Martin, ed. Apoptosis and Cancer, Karger Landes, Basel, 1997, pp. 98-115.
184. Amarante-Mendes, G.P., Finucane, D.M., Martin, S.J., Cotter, T.G., Salvesen, G.S., and Green, D.R. Anti-apoptotic oncogenes prevent caspase-dependent and independent cell death. Cell Death Diff.,5, 298-306, 1998.
185. Lin, T., Brunner, T., Tietz, B., Madsen, J., Bonfoco, E., Reaves, M., Huflejet, M., and Green, D.R. Fas ligand-mediated killing by intestinal intraepithelial lymphocytes: Participation in intestinal graft-versus-host disease. J. Clin. Invest., 101, 570-577, 1998.
186. von Willebrand, M., Williams, S., Gilman, J., Tailor, P., Jascur, T., Amarante-Mendes, G.P., Green, D.R., and Mustelin, T. Modification of phosphatidylinositol 3-kinase SH2 binding properties by Abl- or Lck-mediated tyrosine phosphorylation. J. Biol. Chem., 273, 3994-4000, 1998.
187. Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., and Green, D.R. DNA damaging agents induce expression of Fas-ligand and subsequent apoptosis in T lymphocytes via the stress-activated protein kinase pathway. Mol. Cell, 1, 543-551, 1998.
188. Van Antwerp, D.J., Martin, S.J., Verma, I.M., and Green, D.R. Inhibition of TNF-induced apoptosis by NF-B. Trends Cell Biol., 8, 107-111, 1998.
189. Green, D.R., and Amarante-Mendes, G. The Point of no return: Mitochondria, caspases, and the commitment to cell death. In S. Kumar (ed.), Apoptosis: Biology, Mechanisms and Role in Disease, Springer-Verlag, Heidelberg. 1998. pp 45-62.
190. Green, D.R., and Kroemer, G. The central executioner of apoptosis: Mitochondria or caspases? Trends Cell Biol., 8, 267-271, 1998.
191. Waterhouse, N.J., Finucane, D.M., Green, D.R., Elce, J.S., Kumar, S., Alnemri, E.S., Litwack, G., Khanna, K.K., Lavin, M.F., and Watters, D.J., Calpain Activation is upstream of the caspases in radiation-induced apoptosis. Cell Death. Diff. 5, 1051-1061, 1998.
192. Green, D.R., and Reed, J.C. Mitochondria and apoptosis. Science, 281, 1309-1312, 1998.
193. Stennicke, H.R., Jurgensmeier, J.M., Shin, H., Wolf, B.B., Yang, X., Zhou, Q., Ellerby, H.M., Ellerby, L.M., Bredesen, D., Green, D.R., Reed, J.C., Froelich, C.J., and Salvesen, G.S. Pro- caspase-3 is the major physiologic target of caspase-8. J. Biol. Chem. 273, 27084-27090, 1998.
194. Green, D.R. Apoptotic pathways: The roads to ruin. Cell, 94, 695-698, 1998.
195. Bonfoco, E., Brunner, T., Lin, T., Griffith, T.S., Stuart, P.M., Gao, Y., Ferguson, T.A., and Green, D.R. Inducible nonlymphoid expression of Fas-ligand is responsible for superantigen-triggered peripheral deletion of T cells. Immunity, 9, 711-720, 1998.
196. Green, D.R., and Beere, H. Killers or clean-up crew--How central are the central mechanisms of apoptosis? in Hickman, J.A., and Dive, C. Apoptosis and Cancer Therapy Humana Press, Totowa, NJ, 1999. pp 157-174.
197. Newmeyer, D.D., and Green, D.R. Surviving the cytochrome seas. Neuron , 21, 653-655, 1998.
198. Yang, X., Stennicke, H.R., Wang, B., Green, D.R., Jänicke, R.U., Srinivasan, A., Seth, P. Salvesen, G.S., and Froelich, C.J. Granzyme B Mimics Apical Caspases: description of a unified pathway for trans-activation of executioner caspases-3 and -7. J. Biol. Chem., 278, 34278-34283, 1998.
199. Green, D.R. Apoptosis. Death Deceiver (News and Views). Nature, 396, 629-630, 1998.
200. Finucane, D.M., Bossy-Wetzel, E., Waterhouse, N., Cotter, T.G., and Green, D.R. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl- xL. J. Biol. Chem., 274, 2225-2233, 1999.
201. Kasibhatla, S., Genestier, L., and Green, D.R. Regulation of Fas-ligand expression during activation-induced cell death in T lymphocytes via the activation of NF-B. J. Biol. Chem., 274, 987-992, 1999.
202. Blackstone, N.W., and Green, D.R. The evolution of a mechanism of cell suicide. Bioessays, 21, 84-88, 1999.
203. Genestier, L., Brunner, T., Kasibhatla, S., and Green, D.R. Transforming growth factor-1 inhibits Fas-ligand expression and subsequent activation-induced cell death in T cells via down- regulation of c-Myc. J. Exp. Med., 189, 231-239, 1999.
204. Le-Niculescu, H., Bonfoco, E., Kasuya, Y., Claret, F.X., Green, D.R., and Karin, M. Stress-induced activation of the JNK pathway in neuronal cells results in Fas ligand induction leading to cell death. Mol. Cell Biology, 19, 751-763, 1999.
205. Wolf, B.B., and Green, D.R. Suicidal tendencies: Caspase activation in apoptosis. J. Biol. Chem 274, 20049-20052, 1999.
206. Sun, X.M., MacFarlane, M., Zhuang, J., Wolf, B.B., Green, D.R., Cohen, G.M. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J. Biol. Chem. 274, 5053-5060, 1999.
207. Han, Z., Boyle, D.L., Shi, Y., Green, D.R., and Firestein, G.S. p53 mutations in rheumatoid arthritis are dominant negative. Arth. Rheum. 42, 1088-1092, 1999.
208. Slee, E.A., Harte, M.T., Kluck, R.M., Wolf, B.B., Casiano, C.A., Newmeyer, D.D., Wang, H.G., Reed, J.C., Nicholson, D.W., Alnemri, E.S., Green, D.R., and Martin, S.J. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, -10 in a caspase-9- dependent manner. J. Cell Biol. 144, 281-292, 1999.
209. Green. D.R. Harms way: Polyglutamine repeats and the activation of an apoptotic pathway. Neuron, 22, 416-417, 1999.
210. Bossy-Wetzel, E., and Green, D.R. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J. Biol. Chem., 274, 17484-17490, 1999.
211. Finucane, D.M., Cotter, T.G., and Green, D.R. Caspases and the commitment to death. In: D. Watters and M. Lavin (eds) Signalling Pathways in Apoptosis, in the series "Modern Genetics", Series Editor, Rick Lathe, Harwood Academic Publishers, Chur, Switzerland. 1999. pp 227-245.
212. Bossy-Wetzel, E., and Green, D.R. Apoptosis: Checkpoint at the mitochondrial frontier. Mutation Res., 434, 243-251, 1999.
213. Kullman, F., Judex, M., Neudecker, I., Lechner, S., Justen, H.P., Green, D.R., Wessinghage, D., Firestein, G.S., Scholmerich, B., Muller-Ladner, U. Analysis of the p53 tumor suppressor gene in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum, 42,1594-1600, 1999.
214. Finucane, D., Waterhouse, N., Amarante-Mendes, G.P., Cotter, T.G., and Green, D.R. Collapse of the inner mitochondrial transmembrane potential is not a universal requirement for apoptosis. Exp. Cell Res., 251, 166-174, 1999.
215. Villunger, A., Ghaffari-Tabrizi, N., Tinhofer, I., Krumbock, N., Bauer, B., Schneider, T, Kasibhatla, S., Greil, R, Baier-Bitterlich, G., Uberall, F., Green, D.R., and Baier, G. Synergistic action of protein kinase c and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells. Eur. J. Immunol., 29: 3549-3561, 1999.
216. Wolf, B.B., Goldstein, J.C., Stennicke, H.R., Beere, H., Amarante-Mendes, G.P., Salvesen, G.S., and Green, D.R. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation Blood, 94: 1683-1692, 1999.
217. Askew, D.J., Kuscuoglu, U., Brunner, T., Green, D.R., and Miesfeld, R.L.. Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis. Cell Death Differ 6, 796-804, 1999.
218. Amarante-Mendes, G.P., and Green, D.R.. The regulation of apoptotic cell death. Braz J Med Biol Res 32, 1053-1061, 1999.
219. Green, D.R. The paths to perdition: Routes to apoptotic cell death. Rheumatology Grand Rounds, 2, 1-8, 1999.
220. Wolf, B.B., Schuler, M., Echeverri, F., and Green, D.R. Caspase-3 is the primary activator of apoptotic DNA fragmentation via DFF45/ICAD inactivation. J. Biol. Chem., 274, 30651-30656, 1999.
221. Villalba, M., Kasibhatla, S., Genestier, L., Mahboubi, A., Green, D.R., and Altman, A. PKC cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death. J. Immunol., 163, 5813-5819, 1999.
222. Kluck, R.M., Degli Esposti, M., Perkins, G., Renken, C., Kuwana, T., Bossy-Wetzel, E., Goldberg, M., Allen, T., Barber, M.J., Green, D.R., and Newmeyer, D.D. The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosolic PEF (permeability enhancing factor). J. Cell Biol., 147, 809-822, 1999.
223. Pinkoski, M.J., and Green, D.R. Fas ligand, death gene. Cell Death Diff., 6, 1174-1181, 1999.
224. Ferguson, T.A., and Green, D.R. T cells are just dying to accept grafts. Nat. Med., 5, 1231-1232, 1999.
225. Lin, T., Yoshida, H., Matsuzaki, G., Reaves, M., Guehler, S.R., Nomoto, K., Barrett, T.A., Green, D.R. Autospecific thymocytes that escape negative selection find sanctuary in the intestine. J. Clin. Invest., 104, 1297-1305, 1999.
226. Tak, P.P., Zvaifler, N.J., Green, D.R., and Firestein, G.S. Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases. Immunol Today, 21, 78-82, 2000.
227. Schuler, M., Bossy-Wetzel, E., Goldstein, J.C., Fitzgerald, P., and Green, D.R. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J. Biol. Chem., 275, 7337-7342, 2000.
228. Brunner, T., Kasibhatla, S., Pinkoski, M.J., Frutschi, C., Yoo, N.J., Echeverri, F., and Green, D.R. Expression of Fas-ligand in activated T cells is regulated by c-Myc. J. Biol. Chem., 275, 9767- 9772, 2000.
229. Lin, T., Genestier, L., Castro, A., Nicholas, S., Pinkoski, M.J., Mogil, R., Schuchman, E.H., Kolesnick, R.N. and Green, D.R., Role of acidic sphingomyelinase in Fas/CD95-mediated cell death. J. Biol. Chem., 275, 8657-8663, 2000.
230. Harwood, F.G., Kasibhatla, S., Petak, I., Green, D.R., and Houghton, J.A. (Shared Senior Authorship) Regulation of FasL by NF-kB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells. J. Biol. Chem., 275, 10023-10029, 2000.
231. Pinkoski M.J., Green D.R. Cloak and dagger in the avoidance of immune surveillance. Curr Opin Genet Dev 10, 114-119, 2000.
232. Newmeyer, D.D., Bossy-Wetzel, E., Kluck, R.M., Wolf, B.B., Beere, H.M., and Green, D.R. Bcl-xL blocks cytochrome c release from mitochondria but does not inhibit the function of Apaf- 1. Cell Death Diff., 7, 402-407, 2000.
233. Goldstein, J.C., Waterhouse, N.J., Juin, P., Evan, G.I., and Green, D.R. The co-ordinate release of cytochrome c during apoptosis is rapid, complete, and kinetically invariant. Nature Cell Biol, 2, 156-162, 2000.
234. Bossy-Wetzel, E. and Green, D.R. Detection of apoptosis by Annexin-V labeling. Meth Enzymol, 322, 15-18, 2000.
235. Bossy-Wetzel, E. and Green, D.R. Assays for cytochrome c release from mitochondria during apoptosis. Meth Enzymol, 322, 235-242, 2000.
236. Pinkoski, M.J., T. Brunner, T., Green, D.R., and Lin, T., Fas and Fas ligand in gut and liver. AJP - GI 278, G354-G366, 2000.
237. Barry, M., Heibein, J.A., Pinkoski, M.J., Lee, S.F., Moyer, R.W., Green, D.R., and Bleackley, R.C. Granzyme B short circuits the need for caspase 8 activity during granule-mediated CTL killing by directly cleaving Bid. Mol. Cell Biol., 20, 3781-3794, 2000.
238. Melino, G., Bernassola, F., Catani, M.V., Rossi, A., and Green, D.R. Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation. Cancer Res., 60, 2377-2383, 2000.
239. Green, D.R. and Beere, H.M. Apoptosis—gone but not forgotten. Nature, 405, 28-29, 2000.
240. Beere, H.M., Wolf, B.B., Mosser, D.D., Cain, K., Kuwana, T., Morimoto, R.I., Cohen, G.M., and Green, D.R. Heat shock protein 70 (Hsp70) inhibits apoptosis by preventing recruitment of procaspase-9 to the apaf-1 apoptosome. Nature Cell Biol., 2, 469-475, 2000.
241. Green, D.R. and Schuler, M. T cell development: Some cells get all the breaks. Nature Immunology, 1, 15-17, 2000.
242. Green, D.R. Apoptotic Pathways: Paper wraps stone blunts scissors. Cell, 102, 1-4, 2000.
243. Green, D.R. Apoptosis and sphingomyelin hydrolysis: The Flip Side. J. Cell Biol., 150, F5-F7, 2000..
244. Nakamura, K., Bossy-Wetzel, E., Burns, K., Fadel, M., Lozyk, M., Goping, I.S., Opas, M., Bleackley, R.C., Green, D.R., and Michalak, M. Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J. Cell Biol., 150, 731-740, 2000.
245. Goldstein, J.C., Kluck, R.M., and Green, D.R. A single cell analysis of apoptosis: Ordering the apoptotic phenotype. Ann NY Acad Sci, 926, 132-141, 2000.
246. Kasibhatla, S., Beere, H.M., Brunner, T., Echeverri, F., and Green, D.R., A “non-canonical” DNA binding element mediates the response of the Fas-ligand promoter to c-Myc. Curr. Biol., 10, 1205-1208, 2000.
247. Pinkoski, M.J., and Green, D.R. Murder by proxy. Nature Immunol., 1, 461-462, 2000.
248. Heibein, J.A., Goping, I.S., Barry, M., Pinkoski, M.J., Shore, G.C., Green, D.R., and Bleackley, R.C. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members Bid and Bax. J. Exp. Med., 192, 1391-1401, 2000.
249. Zimmermann, K.C., Waterhouse, N.J., Schuler, M., Goldstein, J.C., and Green, D.R. Aspirin induces apoptosis via release of cytochrome c from mitochondria. Neoplasia, 2, 505-513, 2000.
250. von Ahsen O., Waterhouse, N..J.., Kuwana, T., Newmeyer, D.D., Green, D.R.., The 'harmless' release of cytochrome c. Cell Death Differ. 7, 1192-1199, 2000.
251. Beere, H., and Green, D.R. Stress management—heat hock protein (hsp) 70 and the regulation of apoptosis. Trends Cell Biol., 11, 6-10, 2001.
252. Martinou, J.C. and Green, D.R. Breaking the mitochondrial barrier. Nature Rev. Mol. Cell Biol., 2, 63-67, 2001.
253. Inagaki-Ohara, K., Yada, S., Takamura, N., Reaves, M., Yu, X., Liu, E., Rooney, I., Nicholas, S., Castro, A., Ware, C.F., Green, D.R. and Lin, T. p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system. Oncogene, 20, 812- 818, 2001.
254. Green, D.R. Apoptosis and the Immune Response. In: Samter’s Immunologic Disease. Sixth edition. K.F. Austin, M.M. Frank, J.P. Atkinson, and H. Cantor, eds. Lippincott, Williams & Wilkins, Baltimore, MD., 2001. pp.127-135.
255. Pinkoski, M.J., Heibein, J.A., Waterhouse, N.J., Kuwana, T., Wolf, B.B., Goldstein, J.C., Newmeyer, D.D., Bleackley, R.C., and Green, D.R. The mitochondrial pathway is the favored mechanism in granzyme B-mediated apoptosis. J. Biol. Chem., 276, 12060-12067, 2001.
256. Waterhouse, N.J., Goldstein, J.C., von Ahsen, O., Schuler, M., Newmeyer, D.D., and Green, D.R. Cytochrome c maintains mitochondrial-transmembrane potential and ATP generation following outer mitochondrial membrane permeabilization during the apoptotic process. J. Cell Biol., 153, 319-328, 2001.
257. Waterhouse, N.J., Goldstein, J.C., Kluck, R.M., Newmeyer, D.D., and Green, D.R. The (holey) study of mitochondria in apoptosis. Methods Cell Biol., 66, 365-391, 2001.
258. Green, D.R., and Beere, H.M. Mostly dead. Nature, 412, 133-135, 2001.
259. Wolf, B.B., Sculer, M., Li, W., Eggers-Sedlet, B., Lee, W., Tailor, P., Fitzgerald, P., Mills, G.B., and Green, D.R. Ovarian cancer cell-line cytosols resist cytochrome c-dependent caspase activation due to diminished or absent Apaf-1 activity. J. Biol. Chem., 276, 34244-34251, 2001.
260. Wasem, C., Frutschi, C., Arnold, D., Vallan, C., Lin, T., Green, D.R., Mueller, C., Brunner, T. Accumulation and Activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease. J Immunol. 167, 2936-2941, 2001.
261. Schuler, M., and Green, D.R. Mechanisms of p53-dependent apoptosis. Biochem. Soc. Trans. 29, 684-688, 2001.
262. Ethell, D.,W. and Green, D.R. Mitochondria and apoptosis, the stepping stones on the path to death. In: C.E. Henderson, D. Green, J. Mariani, Y. Christen (Eds) Neuronal Death by Accident or by Design. Springer-Verlag, Berlin. 2001. p. 1-14.
263. Petit, F., Corbeil, J, Lelièvre, J.D., Moutouh-de Parseval, L., Pinon, G., Green, D., Ameisen, J.C., and Estaquier, J. Role of CD95-activated Caspase-1 processing of IL-1ß in TCR-mediated proliferation of HIV-infected CD4+ T-cells. Eur. J. Immunol., 31, 3513-3524, 2001.
264. Zimmermann, K.C., and Green, D.R. How cells die: Apoptosis pathways. J Allergy Clin Immunol 108, 99S-103S, 2001.
265. Green D.R., Ferguson, T.A., The role of Fas-ligand in immune privilege. Nat Rev Mol Cell Biol. 2, 917-924, 2001.
266. Zimmermann, K.C., Bonzon, C., and Green, D.R. The machinery of programmed cell death. Pharmacol Ther., 92, 57-70, 2001.
267. Kuwabara, I., Kuwabara, Y., Yang, R.Y., Schuler, M., Green, D.R., Zuraw, B.L., Hsu, DK, and Liu F.T. Galectin-7 (PIG1:p53-induced gene 1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem., 277, 3487-3497, 2002.
268. Yamanishi, Y., Boyle, D.L., Han, Z., Pinkoski, M.J., Mahboubi, A., Lin, T., Zvaifler, N.J., Green, D.R., and Firestein, G.S. (Shared Senior Authorship) P53 regulates apoptosis, synovitis, and joint destruction in collagen-induced arthritis. Am. J. Pathol., 160, 123-130, 2002.
269. Daigle, I., Yousefi, S., Colonna, M., Green, D.R., and Simon, H.U. Death receptors block cytokine-induced anti-apoptotic signaling mediated by SHP-1 in neutrophils. Nat. Med., 8, 61-67, 2002.
270. James, E.R., and Green, D.R. Infection and the origins of apoptosis. Cell Death Diff., 9, 355- 357, 2002..
271. Pinkoski, M.J., and Green, D.R. Lymphocyte apoptosis: Refining the paths to perdition. Curr. Op. Hematol., 9, 43-49, 2002.
272. Reed, J.C., and Green, D.R. Remodeling for demolition: Changing mitochondrial ultra-structure during apoptosis. Mol. Cell, 9, 1-3, 2002.
273. Zimmermann, K.C., Ricci, J.E., Droin, N.M., and Green, D.R. The role of ARK in stress-induced apoptosis in Drosophila cells. J. Cell Biol. 156, 1077-1087, 2002.
274. Ethell, D.W. and Green, D.R. Assessing cytochrome c release from mitochondria. In: LeBlanc, A.C. (ed) Neuromethods 37: Apoptosis Techniques and Protocols, 2nd ed., Humana Press, Totowa, N.J., 2002, pp. 21-34.
275. Wolf, B.B., Green, D.R. Apoptosis: letting slip the dogs of war. Curr Biol. 12, R177-179, 2002.
276. Pinkoski, M.J., and Green, D.R. Dying for acceptance: apoptosis in tolerance. Curr. Opin, Organ Transpl. 7. 2-6, 2002.
277. Green, D.R. and Evan, G.I. A matter of life and death. Cancer Cell 1, 19-30, 2002.
278. Ferguson, T.A., Herndon, J., Elzey, B., Griffith, T.S., Schoenberger, S., and Green, D.R. Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J Immunol. 168, 5589-5595, 2002 .
279. Ferguson, T.A., Green, D.R., and Griffith, T.S. Cell death and immune privilege. Int. Rev. Immunol., 21, 153-172, 2002.
280. Waterhouse, N.J., Ricci, J.E., and Green, D.R. And all of a sudden it's over: mitochondrial outer- membrane permeabilization in apoptosis. Biochimie 84, 113-121, 2002.
281. Yamanishi, Y., Boyle, D.L., Rosengren, S., Green, D.R., Zvaifler, N.J., and Firestein, G.S. Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc. Natl. Acad. Sci. USA, 99, 10025-10030, 2002.
282. Muthumani, K., Hwang, D.S., Desai, B.M., Zhang, D., Dayes, N.S., Green, D.R., Weiner, D.B. HIV-1 Induces apoptosis through caspase 9 in T cells and PBMC's. J Biol Chem., 277, 37820- 37831, 2002.
283. Ethell, D.W., Kinloch, R., and Green, D.R. Metalloproteinase inhibitors increase -amyloid neurotoxicity through enhancement of Fas-Fas ligand interactions. Curr. Biol., 12, 1595-1600, 2002.
284. Pinkoski, M.J., Droin, N.M., Green, D.R. TNF upregulates non-lymphoid Fas-ligand following superantigen-induced peripheral lymphocyte activation. J. Biol. Chem., 277, 42380-42385, 2002.
285. Kuwana, T., Mackey, M.R., Perkins, G., Ellisman, M., Latterich, M., Green, D.R., and Newmeyer, D.D. Bid, Bax and lipids cooperate to form supramolecular pores in the outer mitochondrial membrane. Cell, 111, 331-342, 2002.
286. Dejardin, E., Droin, NM, Delhase, M, Haas, E, Cao, Y, Makris, C, Li, ZW, Karin, M, Ware, CF, and Green, DR. The lymphotoxin- receptor induces different patterns of gene expression via two NF-B pathways. Immunity, 17, 525-535, 2002.
287. Pinkoski, M.J., Droin, N.M., Lin, T., Genestier, L., Ferguson, T.A., and Green, D.R. Non- lymphoid Fas-ligand in peptide induced peripheral lymphocyte deletion. Proc. Natl. Acad. Sci. USA, 99, 16174-16179, 2002.
288. Schuler, M., Maurer, U., Goldstein, J.C., Breitenbucher, F., Hoffarth, S., Waterhouse, N.J., and Green, D.R. P53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation. Cell Death Diff., 10, 451-460, 2003.
289. Bueno-da-Silva, A.E.B., Brumatti, G., Russo, F.O., Green, D.R., and Amarante-Mendes, G.P. Bcr-Abl-mediated resistance to apoptosis is independent of constant tyrosine-kinase activity. Cell Death Diff., 10, 592-598, 2003.
290. Ricci, J.E., Gottlieb, R.A., and Green, D.R. Caspase-induced loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J. Cell Biol., 160, 65-75, 2003.
291. Pinkoski, M.J., and Green, D.R. Granzyme A: The road less travelled. Nat. Immunol., 106-108, 2003.
292. Green, D.R. The suicide in the thymus. A twisted trail. Nat. Immunol., 4, 207-208, 2003.
293. Boatright, K.M., Renatus, M., Scott, F.L., Sperandio, S., Shin, H., Ricci, J.E., Idris, W.A., Sutherlin, D.P., Green, D.R., and Salvesen, G.S. A unified model for apical caspase activation. Mol. Cell, 11, 529-541, 2003.
294. Green, D.R. Death and NF-B in T cell activation: Life at the edge. Mol. Cell, 11, 551-552, 2003.
295. Ricci, J.E., Waterhouse, N., and Green, D.R. Mitochondrial functions during cell death, a complex (I-V) dilemma. Cell Death Diff., 10, 488-492, 2003.
296. Moreau, C., Cartron, P.F., Hunt, A., Meflah, K., Green, D.R., Evan, G., Vallette, F.M., and Juin, P. Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins. J. Biol. Chem. 278, 19426-19435, 2003.
297. Green, D.R. Overview—Apoptotic pathways in the immune system. Immunol. Rev. 193, 4-9, 2003.
298. Green, D.R., Droin, N.M., and Pinkoski, M.J. Activation-induced apoptosis in T lymphocytes. Immunol. Rev. 193, 70-81, 2003.
299. Van Stipdonk, M.J., Hardenberg, G., Bijker, M.S., Lemmens, E.E., Droin, N.M., Green, D.R., and Schoenberger, S.P. Dynamic programming of CD8(+) T lymphocyte responses. Nat Immunol., 4, 361-365, 2003.
300. Lahm A, Paradisi A, Green DR, Melino G. Death fold domain interaction in apoptosis. Cell Death Differ. 10, 10-12, 2003.
301. Derudder, E., Dejardin, E., Pritchard, L.L., Green, D.R., Körner, M., and Baud, V. RelB/p50 dimers are differentially regulated by TNF- and lymphotoxin- receptor activation: critical roles for p100. J. Biol. Chem. 278, 23278-23284, 2003.
302. Droin, N.M., Pinkoski, M.J., Dejardin, E., and Green, D.R. Egr family members regulate non- lymphoid expression of Fas-ligand, TRAIL, and TNF during immune responses. Mol. Cell. Biol., 23, 7638-7647, 2003.
303. Green, D.R. Introduction: apoptosis in the development and function of the immune system. Semin. Immunol., 15, 121-123, 2003.
304. Pagliari, L.J., Pinkoski, M.J., and Green, D.R.. Chapter 31. Apoptosis signaling: A means to an end. In Bradshaw, R. and Edward Dennis, E. (Eds.) Handbook of Cell Signaling, 331, 431-439, 2003.
305. Chipuk, J.E., Maurer, U., Green, D.R., and Schuler, M. (Shared Senior Authorship) Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription, Cancer Cell, 4, 371-381, 2003.
306. James, E.R., Robertson, L., Ehlert, E., Fitzgerald, P., Droin, N., and Green, D.R. Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells. Invest Ophthalmol Vis Sci., 44, 5269-5276, 2003.
307. Chipuk, J.E., and Green, D.R. p53's believe it or not: lessons on transcription-independent death. J Clin Immunol. 23, 355-361, 2003.
308. Scott, C.L., Schuler, M., Marsden, V.S., Egle, A., Pellegrini, M., Nesic, D., Gerondakis, S., Nutt, S.L., Green, D.R., and Strasser, A. Apaf-1 and Caspase-9 do not act as tumor suppressors in myc- induced lymphomagenesis. J. Cell Biol. 164, 89-96, 2004.
309. Melino, G., Bernassola, F., Ranalli, M., Yee, K., Zong, W.Z., Corazzari, M., Knight, R.A., Green, D.R., Thompson, C., and Vousden, K.H.. p73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J. Biol. Chem., 279, 8076-8083, 2004.
310. Chipuk, J.E., Kuwana, T., Bouchier-Hayes, L., Newmeyer, D., Schuler, M., and Green, D.R. Direct activation of Bax-mediated mitochondrial permeabilization and apoptosis by p53. Science, 303, 1010-1014, 2004.
311. Droin, N.M., and Green, D.R. Role of Bcl-2 family members in immunity and disease. Biochim. Biophys. Acta., 1644, 179-188, 2004.
312. Chipuk, J.E., and Green, D.R. Cytoplasmic p53: Bax and Forward. Cell Cycle. 3, 429-431, 2004.
313. James, E.R., and Green, D.R. Manipulation of apoptosis in the host-parasite interaction. Trends Parasitol., 20, 280-287, 2004.
314. Ricci, J.E., Munoz-Pinedo, C., Fitzgerald, P., Bailly-Maitre, B., Perkins, G.A., Yadava, N., Scheffler, I.E., Ellisman, M.H., and Green, D.R. 2004. Disruption of mitochondrial function during apoptosis mediated by caspase cleavage of the p75 subunit (NDUSF1) of complex I of the electron transport chain. Cell, 117, 773–786, 2004.
315. Green, D.R., and Kroemer, G. The pathophysiology of mitochondrial cell death. Science, 305, 626-629, 2004.
316. Torgler, R., Jakob, S., Ontsouka, E., Nachbur, U., Mueller, C., Green, D.R., and Brunner, T. Regulation of activation-induced Fas (CD95/Apo-1) ligand expression in T cells by the Cyclin B1/Cdk1 complex, J. Biol. Chem., 279, 37334-37342, 2004.
317. Viatour, P., Dejardin, E., Warnier, M., Lair, F., Claudio, E., Bureau, F., Marine, J.C., Merville, M.P., Maurer, U., Green, D., Piette, J., Siebenlist ,U., Bours, V., Chariot, A. GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Mol Cell, 16, 35-45, 2004.
318. Yamanishi, Y., Boyle, D.L., Green, D.R., Keystone, E.C., Connor, A., Zollman, S., and Firestein, G.S, p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis. Arthritis Res Ther., 7, R12-R18, 2004.
319. Yada, S., Takamura, N., Inagaki-Ohara, K., O'leary, M.K., Wasem, C., Brunner, T., Green, D.R., Lin, T., and Pinkoski, M.J. The Role of p53 and Fas in a Model of Acute Murine Graft-versus- Host Disease. J. Immunol., 174, 1291-1297, 2005.
320. Schuler, M., and Green, D.R. Transcription, Apoptosis, and p53: Catch-22. Trends Genet., 21, 182-187, 2005.
321. Pinkoski, M.J., and Green, D.R. Apoptosis in the regulation of immune responses. J. Rheumatol. Suppl. 74, 19-25, 2005.
322. Janssen, E.M., Droin, N.M., Lemmens, E.E., Pinkoski, M.J., Bensinger, S.J., Ehst, B.D., Griffith, T.S., Green, D.R., and Schoenberger, S.P. (shared senior authorship) T help controls CD8+ T cell memory through regulation of TRAIL-mediated AICD. Nature, 434, 88-93, 2005.
323. Rossi, M., De Laurenzi, V., Munarriz, E., Green, D.R., Liu, Y.C., Vousden, K.H., Cesareni, G., and Melino, G. The ubiquitin-protein ligase Itch regulates p73 stability, EMBO J., 24, 836-848, 2005.
324. Goldstein, J.C., Muñoz-Pinedo, C., Ricci,, J.E., Adams, S., Kelekar, A., Schuler, M., Tsien, R., and Green, D.R. Cytochrome c is released during apoptosis in a single step. Cell Death Differ., 12, 453-462, 2005.
325. Chipuk, J.E., and Green, D.R. Do apoptotic pathways trigger caspase-independent cell death? Nature Rev. Mol. Cell Biol., 6, 268-275, 2005.
326. Kuwana, T., Bouuchier-Hayes, L., Chipuk, J.E., Sullivan, B., Green, D.R., and Newmeyer, D.D. BH3 domains of BH3-only proteins differentially regulate Bax-mediated membrane permeabilization both directly and indirectly. Mol. Cell, 17, 525-535, 2005.
327. Munoz-Pinedo, C., Green, D.R., and van den Berg, A. Confocal restricted-height imaging of suspension cells (CRISC) in a PDMS microdevice during apoptosis. Lab Chip. 5, 628-633, 2005.
328. Muthumani, K., Choo, A.Y., Hwang, D.S., Premkumar, A,. Dayes, N.S., Harris, C., Green, D.R., Wadsworth SA, Siekierka, J.J., and Weiner, D.B. HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Blood, 106, 2059-2068, 2005.
329. Kasibhatla, S., Jessen, K.A., Maliartchouk, S., Wang, J.Y., English, N.M., Drewe, J., Qiu, L., Archer, S.P., Ponce, A.E., Sirisoma, N., Jiang, S., Zhang, H.Z., Gehlsen, K.R., Cai, S.X., Green, D.R., Tseng, B. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci U S A., 102,12095-12100, 2005.
330. Simelyte E, Rosengren S, Boyle DL, Corr M, Green DR, Firestein GS. Regulation of arthritis by p53: Critical role of adaptive immunity. Arthritis Rheum. 52, 1876-1884, 2005.
331. Green, D.R. Apoptotic pathways: ten minutes to dead. Cell. 121, 671-674, 2005.
332. Saleh, M., Pagliari, L.J., and Green, D.R. Life support: the alpha4 phosphatase subunit in cell survival and apoptosis. Trends Cell Biol. 15, 285-287, 2005.
333. Chipuk, J.E., Bouchier-Hayes, L., Kuwana, T., Newmeyer, D.D., and Green, D.R. Puma couples the nuclear and cytoplasmic pro-apoptotic function of p53. Science, 309, 1732-1735, 2005. 334. Green, D.R., and Kroemer, G. Pharmacologic manipulation of cell death: clinical applications in sight? J. Clin. Invest., 115, 2610-2617, 2005.
335. Spierings, D., McStay, G., Saleh, M., Bender, C., Chipuk, J., Maurer, U., and Green, D.R. Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science, 310, 66- 67, 2005.
336. Pagliari, L.J., Kuwana, T., Bonzon, C., Tu, S., Beere, H.M., and Green, D.R. The multidomain pro-apoptotic molecules Bax and Bak are directly activated by heat. Proc. Natl. Acad. Sci. USA, 102, 17975-17980, 2005.
337. Kasprowicz, D.J., Droin, N., Soper, D.M., Ramsdell, F., Green, D.R., and Ziegler, S.F. Dynamic regulation of FoxP3 expression controls the balance between CD4(+) T cell activation and cell death. Eur J Immunol., 35, 3424-3432, 2005.
338. Waterhouse, N.J., Sedelies, K. A., Sutton, V.R., Pinkoski, M.J., Thia, K.Y., Johnstone, R., Bird, P.I., Green, D.R., and Trapani, J.A. Functional dissociation of m and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B- induced apoptosis. Cell Death Diff., 13, 607-618, 2006.
339. Kiessling, S., and Green, D.R. Cell survival and proliferation in Drosophila S2 cells following apoptotic stress in the absence of the APAF-1 homology, ARK, or downstream caspases. Apoptosis, 11, 497-507, 2006.
340. Tu, S., McStay, G.P., Boucher, L.M., Mak, T., Beere, H.M., and Green, D.R. In situ “trapping” of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nature Cell Biol., 8, 72-77, 2006.
341. Saleh, M., Mathison, J.C., Wolinski, M.K., Bensinger,S.J., Fitzgerald, P., Ulevitch, R.J., Green, D.R., and Nicholson, D.W. (shared senior authorship) Enhanced bacterial clearance and sepsis resistance in caspase-12 deficient mice. Nature, 440, 1064-1068, 2006.
342. Bonzon, C., Bouchier-Hayes, L., Pagliari, L.J., Green, D.R., Newmeyer, D.D. Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol. Biol. Cell 17, 2150-2157. 2006.
343. Pinkoski, M,J., Waterhouse, N,J, Green D.R. Mitochondria, apoptosis and autoimmunity. In Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun. Basel, Karger, 2006, vol 9, pp 55-73, 2006.
344. Maurer, U., Charvet, C., Wagman, A.S., Dejardin, E., and Green, D.R. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of Mcl-1. Mol. Cell, 21, 749-760, 2006.
345. Chipuk, J.E., and Green, D.R. Dissecting p53-dependent apoptosis. Cell Death Differ., 13, 994- 1002, 2006.
346. Green, D.R. At the gates of death. Cancer Cell, 9, 328-330, 2006.
347. Chipuk, J.E., Bouchier-Hayes, L., and Green, D.R. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ., 13, 1396- 1402, 2006.
348. Muñoz-Pinedo, C., Guío-Carrión, A., Goldstein, J.C., Fitzgerald, P., Newmeyer, D.D., and Green, D.R. Different mitochondrial inter-membrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc. Natl. Acad. Sci. USA, 103, 11573-11578, 2006.
349. Dunn, S.R., Phillips, W.S., Spatafora, J.W., Green, D.R., and Weis, V.M. Highly conserved Caspase and Bcl-2 homologues from the sea anemone Aiptasia pallida: Lower metazoans as models for the study of apoptosis evolution. J Mol Evol., 63, 95-107, 2006.
350. Spierings, D.C., Lemmens, E.E., Grewal, K., Schoenberger, S.P., and Green, D.R. Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion. Eur J Immunol., 36, 1707-1717, 2006.
351. Green, D.R., and Chipuk, J.E. p53 and metabolish: Inside the TIGAR. Cell, 126, 30-32, 2006.
352. Green, D.R. Apoptosis. In: Cells, edited by Lewin, B., Cassimeris, L., Lingappa, V.R., and Plopper, G., Jones and Barlett Pub., Sudbury, 2006, pp. 533-559.
353. Griffith, T.S., Kazama, H., Van Oosten, R.L., Earle, J.K., Hendon, J.M., Green, D.R., and Ferguson, T.A. Apoptotic cells induce tolerance by generating helpless CD8 T cells that produce TNF-related apoptosis-inducing ligand (TRAIL). J. Immunol., 178, 2679-2687, 2007.
354. Pop, C., Fitzgerald, P., Green, D.R., and Salvesen, G. The role of proteolysis in caspase-8 activation and stabilization. Biochemistry, 46, 4398-4407, 2007.
355. Colell, A., Ricci, J.E., Tait, S., Milasta, S., Maurer, U., Bouchier-Hayes, L., Fitzgerald, P., Guio- Carrion, A., Waterhouse, N.J., Li, C.W., Barbry, P., Newmeyer, D.D., Beere, H.M., and Green, D.R. GAPDH and autophagy protect cells from caspase-independent cell death. Cell, 129, 983- 997, 2007.
356. Dunn, S.R., Phillips, W.S., Green, D.R., and Weis, V.M. Knockdown of actin and caspase gene expression by RNA interference in the symbiotic anemone Aiptasia pallida. Biol. Bull. 212, 250- 258, 2007.
357. Sun, M. G., Williams, J., Munoz-Pinedo, C., Perkins, G. A., Brown, J. M., Ellisman, M. H., Green, D. R., and Frey, T. G. Correlated three-dimensional light and electron microscopy reveals extensive transformation of the mitochondrial inner membrane during apoptosis. Nature Cell Biol., 9, 1057-1065, 2007.
358. Saleh, M., and Green, D.R. Caspase-1 inflammasomes: Choosing between death and taxis. Cell Death Differ., 14, 1559-1560, 2007.
359. Green, D.R. Life, death, BH3 profiles, and the salmon mousse. Cancer Cell, 12, 97-99, 2007.
360. McStay, G.P., Salvesen, G.S., and Green, D.R. Overlapping cleavage motif selectivity of caspases—implications for analysis of apoptotic pathways. Cell Death Differ., 15, 322-331, 2008.
361. Sanjuan, M.A., Dillon, C., Tait, S.W.G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J.L, Withoff, S., and Green, D.R. Toll-like receptor signaling in macrophages links the autophagy pathway to phagocytosis. Nature, 450, 1253-1257, 2007.
362. Bouchier-Hayes, L., Munoz-Pinedo, C., Connell, S., and Green, D.R. Measuring apoptosis at the single cell level. Methods, 44, 222-228, 2008. PMCID: PMC2423010
363. Cassidy-Stone, A., Chipuk, J.E., Ingerman, E., Song, C., Yoo, C., Kurth, M.J., Shaw, J., Hinshaw, J., Green, D.R., and Nunnari, J. Inhibitors of the mitochondrial division dynamin reveal its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev. Cell, 14, 193-204, 2008. PMCID: PMC2267902
364. LeBlanc, P.M., Yeretssian, G., Rutherford, N., Doiron, K., Nadiri, A., Zhu, L., Green, D.R., Gruenheid, S., and Saleh, M. Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host Microbe, 3, 146-157, 2008.
365. Sedelies, K.A, Ciccone, A., Clarke, C.J,, Oliaro, J., Sutton, V.R., Scott, F.L., Silke, J., Susanto, O., Green, D.R., Johnstone, R.W., Bird, P.I., Trapani, J.A., Waterhouse, N.J. Blocking granule- mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity. Cell Death Differ. 15, 708-717, 2008.
366. Green, D.R. Fas Bim Boom! Immunity, 28, 141-143, 2008.
367. Chipuk, J.E., and Green, D.R. How does the Bcl-2 family engage mitochondrial outer membrane permeabilization? Trends Cell Biol., 18, 157-164, 2008.
368. Green, D.R., and McKinnon, P.J. A survivor hits the breaks. Mol. Cell, 29, 411-412, 2008.
369. Oberst, A., Bender, C., and Green, D.R. Living with death: The evolution of the mitochondrial pathway of apoptosis in animals. Cell Death Differ., 15, 1139-1146, 2008. PMCID: PMC2612587
370. Sidi, S., Sanda, T., Kennedy, R.D., Hagen, A.T., Jette, C.A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J.F., Kanki, J.P., Green, D.R., D’Andrea, A.A., and Look, A.T. Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2 and Caspase-3. Cell, 133, 864-877, 2008. PMCID: PMC2719897
371. Kazama, H., Ricci, J.E., Herndon, J.M., Hoppe, G., Green, D.R. and Ferguson, T.A. (Shared senior authorship). Immune tolerance induction by apoptotic cells requires caspase-dependent oxidation of HMGB1. Immunity, 29, 21-32, 2008. PMCID: PMC2704496
372. Sanjuan, M.A., and Green, D.R. Eating for good health. Linking autophagy and phagocytosis in host defense. Autophagy, 4-5, 607-611, 2008. PMCID: PMC2612584
373. Ow, Y.L.P., Green, D.R., Hao, Z., and Mak, T.W. Cytochrome c: functions beyond respiration. Nature Rev. Mol. Cell Biol., 9, 532-542, 2008.
374. Moldoveanu, T., Gehring, K., and Green, D.R. Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature, 456, 404-408, 2008. PMCID: PMC2847431
375. Tait, S.W.G., and Green, D.R. Caspase-independent cell death: leaving the set without the final cut. Oncogene, 27, 6452-6461, 2008. PMCID: PMC2635930
376. Chipuk, J.E., Fisher, J.C., Dillon, C.P., Kriwacki, R.W., Kuwana, T., and Green, D.R. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A 105, 20327-20332, 2008.
377. Green, D.R., and Chipuk, J.E. Apoptosis: Stabbed in the BAX. Nature 455, 1047-1049, 2008.
378. Sanjuan, M.A., Milasta, S., and Green, D.R. Toll-like receptor signaling in the lysosomal pathways. Immunol Rev 227, 203-220, 2009.
379. Godoy, L.C., Munoz-Pinedo, C., Castro, L., Cardaci, S., Schonhoff, C.M., King, M., Tortora, V., Marin, M., Miao, Q., Jiang, J.F., Kapralov, A., Jemmerson, R., Silkstone, G.G., Patel, J.N., Evans, J.E., Wilson, M.T., Green, D.R., Kagan, V.E., Radi, R., and Mannick, J.B. Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Proc Natl Acad Sci U S A, 106, 2653-2658, 2009. PMCID: PMC2650321
380. Lamkanfi, M., Moreira, L.O., Makena, P., Spierings, D.C., Boyd, K., Murray, P.J., Green, D.R., and Kanneganti, T.D. Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood, 113, 2742-2745, 2009. PMCID: PMC2661861
381. Green, D.R. and Kroemer, G. Cytosolic functions of p53. Nature, 458, 1127-1130, 2009. PMCID: PMC2814168
382. Parsons, M.J. and Green, D.R. Mitochondria and apoptosis: a quick take on a long view . F1000 Biology Reports 1,17, 2009.
383. Green, D.R., Ferguson, T.A., Zivogel, L., and Kroemer, G. Immunogenic and tolerogenic cell death. Nature Rev. Immunol., 9, 353-363, 2009. PMCID: PMC2818721
384. Tait, S.W., Bouchier-Hayes, L., Oberst, A., Connell, S., and Green, D.R. Live to dead cell imaging. Methods Mol. Biol., 559, 33-48, 2009.
385. Chipuk J.E., and Green D.R. PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis. Cell Cycle, 8, 2692-2696, 2009.
386. Colell, A., Green, D.R., Ricci, J.E. Novel roles for GAPDH in cell death and carcinogenesis. Cell Death Differ., 16, 1573-1581, 2009.
387. Bouchier-Hayes, L., Oberst, A., McStay, G.P., Connell, S., Tait, S.W.G., Dillon, C.P., Flanagan, J.M., Beere, H.M., and Green, D.R. Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol. Cell, 35, 830-840, 2009. PMCID: PMC2755603
388. Bouchier-Hayes, L., and Green, D.R. Real time with caspase-2. Cell Cycle, 9, 12-13, 2010.
389. Opferman, J.T., and Green, D.R. DUB-le trouble for cell survival. Cancer Cell, 17, 117-119, 2010.
390. Chipuk, J.E., Moldoveanu, T., Llambi, F., Parsons, M.J., and Green, D.R. The Bcl-2 family reunion. Mol. Cell, 37, 299-310, 2010.
391. Pellettieri, J., Fitzgerald, Pl, Watanabe, S., Mancuso, J., Green, D.R., and Sanchez Alvarado, A. Cell death and tissue remodeling in planarian regeneration. Dev. Biol., 338, 76-85, 2010. PMCID: PMC2835816
392. Tait, S.W.J., Parsons, M.J., Llambi, F., Bouchier-Hayes, L, Connell, S., Munoz-Pinedo, C., Green, D.R. Incomplete mitochondrial outer membrane permeabilisation during apoptosis facilitates resistance to caspase independent cell death. Dev. Cell, 18, 802-813, 2010.
393. Green, D.R. Cell competition: Pirates on the Tangled Bank. Cell Stem Cell, 6, 287-288, 2010.
394. Caro-Maldonado, A., Tait, S.W., Ramírez-Peinado, S., Ricci, J.E., Fabregat, I., Green, D.R., Muñoz-Pinedo, C. Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death Differ., 17, 1335-1344, 2010.
395. Rodriguez-Manzanet, R., Sanjuan, M.A., Wu, H.Y., Quintana, F.J., Xiao, S., Anderson, A.C.Weiner, H.L., Green, D.R., Kuchroo, V.K. T- and B-cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc. Natl. Acad. Sci. USA, 107, 8706-8711, 2010.
396. Parsons, M.J., and Green, D.R. Mitochondrial outer membrane permeabilization. In G. Melino and D. Vaux (eds) Cell Death, Wiley-Blackwell, pp. 90-97, 2010.
397. Janssen, E.M., Lemmens, E.E., Gour, N., Reboulet, R.A., Green, D.R., Schoenberger, S.P., and Pinkoski, M.J. Distinct roles of cytolytic effector molecules for antigen-restricted killing by CTL in vivo. Immunol Cell Biol 88, 761-765, 2010.
398. Oberst, A, Pop, C., Tremblay, A.G., Blais, V., Denault, J.B., Salvesen, G.S., and Green, D.R. Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase- 8 activation. J. Biol. Chem. 285, 16632-16642, 2010. PMCID: PMC2878047
399. Green, D.R. Cancer: A wolf in wolf’s clothing. Nature, 465, 433-434, 2010.
400. Tait, S.W.G., and Green, D.R. Mitochondria and cell death: outer mitochondrial membrane permeabilization and beyond. Nat. Rev. Mol. Cell Biol., 11, 621-632, 2010.
401. McAuley, J.L., Chipuk, J.E., Boyd, K.L., Van De Velde, N., Green, D.R., and McCullers, J.A. PB1-F2 proteins from H5N1 and 20th Century pandemic influenza viruses cause immunopathology. PLoS Pathogens, 6, e1001014, 2010.
402. Parsons, M.J., and Green, D.R. Mitochondria in cell death. Essays Biochem., 47, 99-114, 2010.
403. Green, D.R., and Wang, R. Calcium and energy: Making the cake and eating it too? Cell, 142, 200-202, 2010.
404. Busuttil, V., Droin, N., McCormick, L., Bernassola, F., Candi, E., Gerry Melino, G, and Green, D.R. NF-B inhibits T-cell activation-induced p73-dependent cell death by induction of MDM2. Proc. Natl. Acad. Sci. USA, 107, 18061-18066, 2010.
405. Tait, S.W. and Green, D.R. Cell survival in tough times: The mitochondrial recovery plan. Cell Cycle, 9, 4254-4255, 2010.
406. Llambi, F., and Green, D.R. Apoptosis and oncogenesis: Give and take in the BCL-2 family. Curr. Op. Genet. Dev., 21, 12-20, 2011.
407. Pop, C., Oberst, A., Drag, M., Van Raam, B.J., Riedl, S.J., Green, D.R., and Salvesen, G.S. FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J. 433, 447-457, 2011.
408. Niemi, N.M., Lanning, N.J., Klomp, J.A., Tait, S.W., Xu, Y., Dykema, K.J., Murphy, L.O., Gaither, L.A., Xu, H.E., Furge, K.A., Green, D.R., Mackeigan, J.P. MK-STYX, a catalytically inactive phosphatase regulating mitochondrial dependent apoptosis. Mol Cell Biol. 31, 1357- 1368, 2011.
409. Oberst, A., Dillon, C.P., Weinlich, R., McCormick, L.L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G.S., and Green, D.R. Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis. Nature, 471, 363-367, 2011.
410. Ferguson, T.A., Choi, J., and Green, D.R. Armed response: how dying cells influence T-cell functions. Immunol Rev 241, 77-88, 2011. PMID: 21488891
411. Spierings, D.C., McGoldrick, D., Hamilton-Easton, A.M., Neale, G., Murchison, E.P., Hannon, G.J., Green, D.R., and Withoff, S. Ordered progression of stage specific miRNA profiles in the mouse B2 B cell lineage. Blood, 117, 5340-5349, 2011. PMID: 21403133
412. Yeretssian, G., Correa, R.G., Doiron, K., Fitzgerald, P., Dillon, C.P., Green, D.R., Reed, J.C., and Saleh, M. Non-apoptotic role of BID in inflammation and innate immunity. Nature, 474, 96-99, 2011.
413. Gawriluk, T.R., Hale, A.N., Flaws, J.A., Dillon, C.P., Green, D.R., Rucker, E.B. Autophagy is a cell survival program for female germ cells in the murine ovary. Reproduction. 141, 759-765, 2011.
414. Wolkers, M.C., Bensinger, S.J., Green, D.R., Schoenberger, S.P., Janssen, E.M. Interleukin-2 rescues helpless effector CD8(+) T cells by diminishing the susceptibility to TRAIL mediated death. Immunol Lett. 139, 25-32, 2011.
415. Parsons, M.J., Green, D.R.. Death receptors and mitochondria: Life depends on the liver. Hepatology. 54, 13-15, 2011.
416. Shi, L.Z., Wang, R., Green, D.R., and Chi, H. (shaired senior authorship) HIF1-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med., 208, 1367-1376, 2011.
417. Bedford,, D.C., Kasper, L.H., Wang, R., Chang, Y., Green, D.R., and Brindle, P.K. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metabol., 14, 219-230, 2011.
418. Green, D.R., Galluzzi, L., and Kroemer, G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science, 333, 1109-1112, 2011.
419. Charvet, C., Wissler, M., Brauns-Schubert, P., Wang, S.J., Tang, Y., Sigloch, F.C., Mellert, H., Brandenburg, M., Lindner, S.E., Breit, B., Green, D.R., McMahon, S.B., Borner, C., Gu, W., Maurer, U. Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53. Mol Cell. 42, 584-596, 2011.
420. Yang, K., Neale, G., Green, D.R., He, W., and Chi, H. The tumor suppressor Tsc1 enforces quiescence of native T cells to promote immune homeostasis and function. Nature Immunol., 12, 888-897, 2011.
421. Ippagunta, S.K., Malireddi, R.K., Shaw, P.J., Neale, G.A., Walle, L.V., Green, D.R., Fukui, Y., Lamkanfi, M., and Kanneganti, T.D. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nature Immunol., 12, 1010-1016, 2011.
422. Martinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C., Fitzgerald, P., Hengartner, M.O., and Green, D.R. Microtubule-associated protein light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc. Natl. Acad. Sci. USA, 108, 17396-17401, 2011.
423. Llambi, F., Moldoveanu, T., Tait, S.W.G., Bouchier-Hayes, L., Temirov, J., McCormick, L.L., Dillon, C.P., and Green, D.R. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol. Cell, 44, 517-531, 2011.
424. O’Donnell, M.A., Perez-Jimenez, E., Oberst, A., Ng, A., Massoumi, R., Xavier, R., Green, D.R., and Ting, A.T. Caspase-8 inhibits programmed necrosis by processing CYLD. Nature Cell Biol., 13, 1437-1442, 2011.
425. Szymczak-Workman, A.L., Delgoffe, G.M., Green, D.R., and Vignali, D.A.A. Cutting edge: Regulatory T cells do not mediate suppression via programmed cell death pathways. J. Immunol., 187, 4416-4420, 2011.
426. Weinlich, R., Dillon, C.P., and Green, D.R. Ripped to death. Trends Cell Biol., 21, 630-637, 2011.
427. Oberst, A., and Green, D.R. It cuts both ways: Reconciling the dual roles of caspase-8 in cell death and survival. Nature Rev. Mol. Cell Biol., 12, 757-763, 2011.
428. Green, D.R., Oberst, A., Dillon, C.P., Weinlich, R., and Salveson, G.S. RIPK-dependent necrosis and its regulation by caspases: A mystery in five acts. Mol Cell, 44, 9-16, 2011.
429. Anand, P.K., Tait, S.W., Lamkanfi, M., Amer, A.O., Nunez, G., Green, D.R., and Kanneganti, T.D. 2011. TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via ERK activation. J Biol Chem, 286, 42981-42991, 2011.
430. Garrison, S.P., Phillips, D.C., Jeffers, J.R., Chipuk, J.E., Parsons, M.J., Rehg, J.E., Opferman, J.T., Green, D.R., and Zambetti, G.P. 2011. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell Death Differ, 19, 642-649, 2012.
431. Wang, R., Dillon, C.P., Shi, L.Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L.L., Fitzgerald, P., Chi, H., Munger, J., and Green, D.R. Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity, 35, 871-881, 2011.
432. Green, D.R. The end and after: How dying cells impact the living organism. Immunity, 35, 441- 444, 2011.
433. Green, D.R. Immunology: A heavyweight knocked out. Nature 479, 48-50, 2011.
434. Green, D.R. and Van Houten, B. Cell snapshot: Mitochondrial quality control. Cell, 147, 950, 2011.
435. Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., and Schulman, B.A. Atg8 transfer from Atg7 to Atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway. Mol Cell. 44, 451-461, 2011.
436. Zaki, M.H., Vogel, P., Malireddi, R.K., Body-Malapel, M., Anand, P.K., Bertin, J., Green, D.R., Lamkanfi, M., and Kanneganti, T.D. The NOD-Like-2 receptor, TLR12, attenuates colon inflammation and tumorigenesis. Cancer Cell, 20, 649-660, 2011.
437. Wolkers, M.C., Gerlach, C., Arens, R., Janssen, E,M., Fitzgerald, P., Schumacher, T.N., Medema, J.P., Green, D.R., and Schoenberger, S.P. (Shared senior authorship) Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood, 119, 798-804, 2011.
438. Bouchier-Hayes, L., and Green, D.R. Caspase-2: The orphan caspase. Cell Death Diff., 19, 51- 57, 2012.
439. Chipuk, J.E., McStay, G.P., Bharti, A., Kuwana, T., Schafer, B., Siskind, L.J., Obeid, L.M., and Green, D.R. Sphingolipid metabolism cooperates with pro-apoptotic BAK and BAX to promote mitochondrial outer membrane permeabilization and apoptosis. Cell, 148, 988-1000, 2012.
440. Valentin-Vega, Y.A., MacLean, K.H., Tait-Mulder-J., Milasta, S., Steeves, M., Dorsey, F.C., Cleveland, J.L., Green, D.R., and Kastan, M.B. Mitochondrial dysfunction in Ataxia Telangiectasia. Blood, 119, 1490-1500, 2012.
441. Linkermann, A., Bräsen, J.H., De Zen, F., Weinlich, R., Schwendener, R.A., Green, D.R., Kunzendorf, U., and Krautwald, S. Dichotomy between RIP1- and RIP3-mediated necroptosis in Tumor Necrosis Factor α-induced shock. Mol Med. 18, 577-586, 2012.
442. Wang, X., Szymczak-Workman, A.L., Gravano, D.M., Workman, C.J., Green, D.R., and Vignali, D.A. Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis. Cell Death Dis., 3, e270, 2012.
443. Bender, C.E., Fitzgerald, P., Tait, S.W., Llambi, F., McStay, G.P., Tupper, D.O., Pellettieri, J., Alvarado, A.S., Salvesen, G.S., and Green, D.R. Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A., 109, 4904-4909, 2012.
444. Tait, S.W., and Green, D.R. Mitochondria and cell signaling. J Cell Sci. 125, 807-815, 2012.
445. Perciavalle, R.M., Stewart, D.P., Koss, B., Lynch, J., Milasta, S., Bathina, M., Temirov, J., Cleland, M.M., Pelletier, S., Schuetz, J.D., Youle, R.J., Green, D.R., Opferman, J.T. Anti- apoptotic MCL-1 localizes to the mitochondrial matrix and couples fusion to respiration. Nat Cell Biol. 14, 575-583, 2012.
446. Imre, G., Heering, J., Takeda, A.N., Husmann, M., Thiede, B., Zu Heringdorf, D.M., Green, D.R., van der Goot, F.G., Sinha, B., Dötsch, V., and Rajalingam, K. Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J., 31, 2615-2628, 2012.
447. Wang, R., and Green, D.R. The immune diet: Meeting the energetic demands of lymphocyte activation. F1000 Biol Reports, 4,9, 2012.
448. Dillon, C.P., Oberst, A., Weinlich, R., Janke, L.J., Kang, T.B., Ben Moshe, T., Mak, T.W., Wallach, D., and Green, D.R. Survival function of the FADD-caspase-8-cFLIPL complex. Cell Reports, 1, 401-407, 2012.
449. Sano, R., Hou, Y.C., Hedvat, M., Correa, R.G., Shu, C.W., Krajewska, M., Diaz, P.W., Tamble, C.M., Quarato, G., Gottlieb, R.A., Yamaguchi, M., Nizet, V., Dahl, R., Thomas, D.D., Tait, S.W., Green, D.R., Fisher, P.B., Matsuzawa, S., and Reed, J.C. Endoplasmic reticulum protein BI-1 regulates Ca2+-mediated bioenergetics to promote autophagy. Genes Dev., 26, 1041-1054, 2012.
450. Wang, R., and Green, D.R. Metabolic reprogramming and metabolic dependency in T cells. Immunol. Rev. 249, 14-26, 2012.
451. Wang, R. and Green, D.R. Metabolic checkpoints in activated T cells. Nature Immunol., 13, 907-915, 2012.
452. Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D.R., Tessarollo, L., Casellas, R., Zhao, K., and Levens, D. Myc is a universal amplifier of gene expression. Cell, 151, 68-79, 2012.
453. Green, D.R. and Victor, B. The pantheon of the fallen: Why are there so many forms of cell death? Trends Cell Biol., 22, 555-556, 2012.
454. Malatesta, M., Peschiaroli, A., Memmi, E.M., Zhang, J., Antonov, A., Green, D.R., Barlev, N.A., Garabadgiu, A.V., Zhou, P., Melino, G., Bernassola,, F. The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity. Oncogene, advanced online publication.
455. Henault, J., Martinez, J., Riggs, J.M., Tian, J., Mehta, P., Clarke, L., Latz, E., Brinkmann, M.M., Iwasaki, A., Coyle, A.J., Kolbeck, R., Green, D.R., and Sanjuan, M.A. (shared senior authorship). LC3-associated phagocytosis mediates IFN- secretion in response to DNA- immune complexes. Immunity, 37, 986-997, 2012. PMCID: PMC3786711
456. Bossaller, L., Chiang, P.I., Schmidt-Lauber, C., Ganesan, S., Kaiser, W.J., Rathinam, V.A., Mocarski, E.S., Subramanian, D., Green, D.R., Silverman, N., Fitzgerald, K.A., Marshak- Rothstein, A., and Latz, E. Cutting Edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in a RIP3-independent manner. J Immunol., 189, 5508-5512, 2012.
457. Follis, A.V., Chipuk, J. E., Fisher, J. C., Yun, M. K., Grace, C. R., Nourse, A., Baran, K., Ou, L., Min, L., White, S. W., Green, D. R., and Kriwacki, R. W. (shared senior authorship). PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat. Chem. Biol., 9, 163-168, 2013.
458. Green, D.R., and Walczak, H. Apoptosis therapy: Driving cancer cells down the road to ruin? Nat. Med., 19, 131-133, 2013
459. Lindner, A.U., Concannon, C.G., Boukes, G.J., Cannon, M.D., Llambi, F., Ryan, D., Boland, K., Kehoe, J., McNamara, D.A., Murray, F., Kay, E.W., Hector, S., Green, D.R., Huber, H.J., and Prehn J.H. Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy. Cancer Res. 73, 519-528, 2013.
460. Verbist, K.C,, Wang. R,,and Green, D.R. T cell metabolism and the immune response. Semin Immunol. 24, 399-404, 2012.
461. Moldoveanu, T., Grace, C.R., Llambi, F., Nourse, A., Fitzgerald, P., Gehring, K., Kriwacki, R.W., and Green, D.R. BID-induced structural changes in BAK promote apoptosis, Nature Struct. Mol. Biol., 20, 589-597, 2013.
462. Lupfer, C., Thomas, P.G., Anand, P.K., Vogel, P., Milasta, S., Martinez, J., Huang, G., Green, M., Kundu, M., Chi, H., Xavier, R.J., Green, D.R., Lamkanfi, M., Dinarello, C.A., Doherty, P.C., Kanneganti, T.D. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol. 14, 480-488, 2013.
463. Parsons, M.J., McCormick, L., Janke, L., Howard, A., Bouchier-Hayes, L., Green, D.R. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ. 20, 1174-1182, 2013.
464. Kim, J.Y., Zhao, H., Martinez, J., Doggett, T.A., Kolesnikov, A.V., Tang, P.H., Ablonczy, Z., Chan, C.C., Zhou, Z., Green, D.R., and Ferguson, T.A. (Shared senior authorship). Non- canonical autophagy promotes the visual cycle. Cell, 154, 365-376, 2013.
465. Martinez, J., Verbist, K., Wang, R., Green, D.R. The relationship between metabolism and the autophagy machinery during the innate immune response. Cell Metab., 17, 895-900, 2013.
466. Green, D.R., and Rathmell, J. Sweet nothings: sensing of sugar metabolites controls T cell function. Cell Metab. 18, 7-8, 2013
467. Linkermann, A., Bräsen, J.H,, Darding, M., Jin, M.K., Sanz, A.B., Heller, J.O., De Zen, F., Weinlich, R., Ortiz, A., Walczak, H., Weinberg, J.M., Green, D.R., Kunzendorf, U., and Krautwald. S. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A, 110, 12024-12029, 2013.
468. Green, D.R. Pseudokiller, Qu’est que c’est? Immunity, 39, 421-422, 2013.
469. Weinlich, R., Oberst, A., Dillon, C.P., Janke, L.J., Milasta, S., Lukens, J.R., Diego A. Rodriguez, D.A., Prajwal Gurung, P., Savage, C., Kanneganti, T.D., Green, D.R. Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Reports, 5, 340-348, 2013.
470. McCoy, F., Darbandi, R., Lee, H.C., Bharatham, K., Moldoveanu, T., Royappa, G., Dodd, K., Lin, W., Chen, S.I,. Tangallapally, R.P., Kurokawa, M., Lee, R.E., Shelat, A., Chen. T., Green, D.R., Harris, R.A., Lin, S.H., Fissore, R.A., Colbran, R.J., and Nutt, L.K. Metabolic Activation of CaMKII by Coenzyme A. Mol Cell. 52, 325-339, 2013
471. Tait, S.W.T., Oberst, A., Quarato, G., Milasta, S., Haller, M., Wang, R., Karvela, M., Ichim, G., Yatim, N., Albert, M.L., Kidd, G., Wakefield, R., Frase, S. Krautwald, S., Linkermann, A., and Green, D.R. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Reports, 5, 878-885, 2013.
472. Tait, S.W.G., and Green, D.R. Mitochondrial regulation of cell death. In: Baehrecke, E.H., Green, D.R., Kornbluth, S., and Salvesen, G.S. (editors) Cell Survival and Cell Death. Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 2013, pp. 119-133.
473. Figueiredo, N., Chora, A., Raquel, H., Pejanovic, N., Pereira, P., Hartleben, B., Neves-Costa, A., Moita, C., Pedroso, D., Pinto, A., Marques, S., Faridi, H., Costa, P., Gozzelino, R., Zhao, J.L., Soares, M.P., Gama-Carvalho, M., Martinez, J., Zhang, Q., Döring, G., Grompe, M., Simas, J.P., Huber, T.B., Baltimore, D., Gupta, V., Green, D.R., Ferreira, J.A., and Moita, L.F. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity, 39, 874-884. 2013
474. Liu, Y., Shoji-Kawata, S., Sumpter, R.M., Wei, Y., Ginet, V., Zhang, L., Posner, B., Tran, K.A., Green, D.R., Xavier, R.J., Shaw, S.Y., Clarke, P.G., Puyal, J., Levine, B. Autosis is a Na+,K+- ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci U S A. 110, 20364-20371, 2013.
475. Ferguson, T.A., and Green, D.R. Autophagy and phagocytosis converge for better vision. Autophagy, 10, 165-167. 2014.
476. Gilbertson, R., Parker, M., Mohankumar, K., Punchihewa, C., Weinlich, R., Dalton, J., Lee, R., Tatevossian, R., Phoenix, T., Thiruvenkatam, R., Lee, Y., White, E., Tang, B., Orisme, W., Gupta, K., Rusch, M., Chen, X., Nagahawhatte, P. Hedlund, E., Finkelstein, D.m Wu, G., Shurtleff, S., Easton, J., Boggs, K., Yergeau, D., Vadodaria, B., Mulder, H., Becksfort, J., Gupta, P., Huether, R., Ma, J., Song, G., Ding, L., Lu, C., Ochoa, K., Zhao, D., Fulton, R., Fulton, L., Mardis, E., Wilson, R., Downing, J., Green, D.R. Zhang, J., Ellison, D., Li, Y., Gajjar, A., Merchant, T., Boop, F. and Smith, A. C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma. Nature, 506, 451-455, 2014.
477. Linkerman, A., and Green, D.R. Necroptosis. N. Eng. J. Med. 370, 455-465, 2014.
478. Moldoveanu, T., Follis, A.V., Kriwacki, R., and Green, D.R. Many players in Bcl-2 family affairs. Trends Biochem. Sci., Trends Biochem Sci. 39, 101-111, 2014.
479. Shenderov, K., Riteau, N., Yip, R., Mayer-Barber, K.D., Oland, S., Hieny, S., Fitzgerald, P., Oberst, A., Dillon, C.P., Green, D.R., Cerundolo, V., Sher, A. Cutting Edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a Caspase-8- and TRIF-dependent pathway. J Immunol., 192, 2029-2033, 2014.
480. Gurung, P., Anand, P.K., Malireddi, R.K., Vande Walle, L., Van Opdenbosch, N., Dillon, C.P., Weinlich, R., Green, D.R., Lamkanfi, M., Kanneganti, T.D. FADD and Caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol. 192, 1836-1846, 2014.
481. Green, D.R., and Levine, B. To be or not to be? Selective autophagy and cell death govern cell fate. Cell, 157, 65-75, 2014.
482. Newton, K., Hildebrand, J.M., Shen, Z., Rodriguez, D., Alvarez-Diaz, S., Petersen, S., Shah, S., Dugger, D.L., Huang, C., Auwerx, J., Vandenabeele, P., Green, D.R., Ashkenazi, A., Dixit, V.M., Kaiser, W.J., Strasser A,. Degterev, A., and Silke, J. Is SIRT2 required for necroptosis? Nature. 506:E4-6, 2014.
483. Thorburn, J., Andrysik, Z., Staskiewicz, L., Gump, J., Maycotte, P., Oberst, A., Green, D.R., Espinosa, J.M., and Thorburn, A. Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels. Cell Rep. 7, 45-52, 2014.
484. Caro-Maldonado, A., Wang, R., Nichols, A.G., Kuraoka, M., Milasta, S., Sun, L.D., Gavin, A.L., Abel, E.D., Kelsoe, G., Green, D.R., and Rathmell, J.C. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 192, 3626-3636, 2014.
485. Philip, N.H., Dillon, C.P., Snyder, A.G., Fitzgerald, P., Wynosky-Dolfi, M.A., Zwack, E.E., Hu, B., Fitzgerald, L., Mauldin, E.A., Copenhaver, A.M., Shin, S., Wei, L., Parker, M., Zhang, J., Oberst, A., Green, D,R., and Brodsky, I.E.. Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling. Proc Natl Acad Sci U S A. 111, 7385-7390, 2014.
486. Follis, A.V., Llambi, F., Ou, L., Baran, K., Green, D.R., and Kriwacki, R.W. (Shared senior authorship) The DNA binding domain is a promiscuous interaction hub that mediates the nuclear and cytoplasmic functions of p53. Nature Struct. Mol. Biol., 21, 735-743, 2014.
487. Dillon, C.P., Weinlich, R., Rodriguez, D.A., Cripps, J.G., Quarato, G., Gurung, P., Verbist, K.C., Brewer, T.L., Gong, Y., Janke, L.J., Kelliher, M.A., Kanneganti, T.D., and Green, D.R. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell, 157, 1189-1202, 2014.
488. Tait, S.W., Ichim, G., and Green, D.R. Die another way—non-apoptotic mechanisms of cell death. J. Cell Sci., 127, 2135-2144, 2014.
489. Qian, W., Wang, J., Roginskaya, V., McDermott, L.A., Edwards, R.P., Stolz, D.B., Llambi, F., Green, D.R., Houten, B.V. Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells. Oncotarget. 5, 4180-4194, 2014.
490. Orozco, S., Yatim, N., Werner, M.R., Tran, H., Gunja, S.Y., Tait, S.W., Albert, M.L., Green, D.R., Oberst ,A. RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ. 21, 1511-1521, 2014.
491. Ganesan, S., Rathinam, V.A., Bossaller, L., Army, K., Kaiser, W.J., Mocarski, E.S., Dillon, C.P., Green, D.R., Mayadas, T.N., Levitz, S.M., Hise, A.G., Silverman, N., Fitzgerald, K.A. Caspase-8 modulates Dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans. J Immunol., 193, 2519-2530, 2014.
492. Green, D.R., Galluzzi, L., and Kroemer, G. Metabolic control of cell death. Science, 345, 1250256, 2014.
493. Xu, X., Araki, K., Li, S., Han, J.H., Ye, L., Tan, W.G., Konieczny, B.T., Bruinsma, M.W., Martinez, J., Pearce, E.L., Green, D.R., Jones, D.P., Virgin, H.W., and Ahmed, R. Autophagy is essential for effector CD8+ T cell survival and memory formation. Nat Immunol. 15, 1152-1161, 2014.
494. Weinlich, R., and Green, D.R. The two faces of Receptor Interacting Protein Kinase-1. Mol. Cell, 56, 469-480, 2014.
495. Liedmann, S., Hrincius, E.R., Guy, C., Anhlan, D., Dierkes, R., Carter, R., Wu, G., Staeheli, P., Green, D.R., Wolff, T., McCullers,J.A., Ludwig, S., and Ehrhardt, C. Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nat Commun. 5:5645, 2014.
496. Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S.R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.S., Weinlich, R., Vanden Berghe, T., Vandenabeele, P., Pasparakis, M., Bleich, M., Weinberg, J.M., Reichel, C.A., Bräsen, J.H., Kunzendorf, U., Anders, H.J., Stockwell, B.R., Green, D.R., and Krautwald, S. Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A. 111, 6836-6841, 2014.
497. Haverkamp, J.M., Smith, A.M., Weinlich ,R., Dillon, C.P., Qualls, J.E., Neale, G., Koss, B., Kim, Y., Bronte, V., Herold, M.J., Green, D.R., Opferman, J.T., and Murray, P.J. Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways. Immunity. 41, 947-959, 2014.
498. Haller, M., Hock, A.K., Giampazolias, E., Oberst, A., Green, D.R., Debnath ,J,. Ryan, K.M., Vousden, K.H., Tait, S.,W. Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy. 10, 2269-2278, 2014.
499. Li-Harms, X., Milasta, S., Lynch, J., Wright, C., Joshi, A., Iyengar, R., Neale, G., Wang, X., Wang, Y.D., Prolla, T.A., Thompson, J.E., Opferman, J.T., Green, D.R., Schuetz, J., and Kundu, M. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice. Blood. 125, 162-174, 2015.
500. Pelletier, S., Gingras, S., and Green, D.R. Mouse genome engineering via CRISPR-Cas9 for study of immune function. Immunity. 42, 18-27, 2015
501. Green DR. Another face of RIPK1. EMBO Rep. 2015 May 4. pii: e201540470.
502. Rodriguez, D.A., Weinlich, R., Brown, S., Guy, C., Fitzgerald, P., Dillon, C.P., Oberst, A., Quarato, G., Low, J., Cripps, J.G., Chen, T., and Green, D.R. Characterization of RIPK3- mediated phosphorylation of the activation loop of MLKL during necroptosis. Cell Death Differ. 23, 76-88, 2015.
503. Kanneganti, T.D., Kundu, M., and Green, D.R. Innate Immune Recognition of mtDNA—An Undercover Signal? Cell Metab., 21, 793-794, 2015.
504. Martinez, J., Subbarao Malireddi, S., Lu, Q., Dias Cunha, L. Pelletier, S., Gingras, S., Orchard, R., Guan, J.L., Tan, H., Peng, J., Kannegant, T.D., Virgin, H.W., and Green, D.R. Molecular characterization of LC3-associated phagocytosis (LAP) reveals distinct roles for Rubicon, NOX2, and autophagy proteins. Nat. Cell. Biol., 17, 893-906, 2015.
505. Kang, S,, Fernandes-Alnemri, T., Rogers, C., Mayes, L., Wang, Y., Dillon, C,. Roback, L., Kaiser, W., Oberst, A., Sagara, J., Fitzgerald, K.A., Green, D.R., Zhang, J., Mocarski, E,S,, and Alnemri, E.S. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 2015 Jun 24;6:7515. doi: 10.1038/ncomms8515.
506. Follis, A.V., Llambi, F., Merritt, P., Chipuk, J.E., Green, D.R., Kriwacki, R.W. (shared senior authorship) Pin1-induced proline isomerization in cytosolic p53 mediates BAX activation and apoptosis. Mol Cell. 59, 677-684, 2015
507. Yatim, N., Jusforgues-Saklani, H., Orozco, S., Schulz, O., Barreira da Silva, R., Reis E Sousa, C., Green, D.R., Oberst, A., and Albert, M.L. RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8+ T cells. Science. 350, 328-334, 2015.
508. Wan, C.K., Li, P., Spolski, R., Oh, J., Andraski, A.B., Du, N., Yu, Z.X., Dillon, C.P., Green, D.R., Leonard, W.J. IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells. Nat Commun. 6,7988, 2015.
509. Green, D.R., and Llambi, F. Cell Death Signaling. Cold Spring Harb Perspect Biol., 7(12), 2015.
510. Milasta, S., Dillon, C.P., Sturm, O.E., Verbist, K.C., Brewer, T.L., Quarato, G., Brown, S.A., Frase, S., Janke, L.J., Perry, S.S., Thomas, P.G., and Green, D.R. AIF-dependent electron transport complex I assembly is required for T but not B lymphocyte development and function. Immunity, 44, 88-102, 2016.
511. Quarato, G., Guy, C.S., Grace, C.R., Llambi, F., Nourse, A., Rodriguez, D.A., Wakefield, R., Frase, S., Moldoveanu, T., Green, D.R. Sequential engagement of distinct MLKL phosphatidylinositol–binding sites executes necroptosis. Mol. Cell, 61, 589-601, 2016.
512. Llambi, F., Victor, B., Wang, Y., Yang, M., Schneider, D.M., Gingras, S., Zheng, J., Parsons, M.J., Brown, S.A., Pelletier, S., Moldoveanu, T., Chen, T., and Green, D.R. BOK is a non- canonical BCL-2 family effector of apoptosis regulated by ER-associated degradation. Cell, 165, 421-433, 2016.
513. Verbist, K.C., Guy, C.S., Milasta, S., Liedmann, S., M. Kamiński, M.M., Wang, R., and Green, D.R. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature, 582, 389-393, 2016.
514. Green, D.R. The Cell's Dilemma, or the Story of Cell Death. An Entertainment in Three Acts. FEBS J. 2016, in press.
515. Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen, C.B., Bagaitkar, J., Loginicheva, E., Sergushichev, A., Kreamalmeyer, D., Keller, B.C., Zhao, Y., Kambal, A., Green, D.R., Martinez, J., Dinauer, M.C., Holtzman, M.J., Crouch, E.C., Beatty, W., Boon, A.C., Zhang, H., Randolph, G.J., Artyomov, M.N., and Virgin, H.W. Homeostatic control of innate lung inflammation by Vici Syndrome Gene Epg5 and additional autophagy genes promotes influenza pathogenesis. Cell Host Microbe, 19, 102-113, 2016.
516. Park, S., Buck, M.D., Desai, C., Zhang, X., Loginicheva, E., Martinez, J., Freeman, M.L., Saitoh, T., Akira, S., Guan, J.L., He, Y.W., Blackman, M.A., Handley, S.A., Levine, B., Green, D.R., Reese, T.A., Artyomov, M.N., and Virgin, H.W. Autophagy genes enhance murine gammaherpesvirus 68 reactivation from latency by preventing virus-induced systemic inflammation. Cell Host Microbe, 19, 91-101, 2016.
517. Correia-Melo, C., Marques, F.D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B.M., Miwa, S., Birch, J., Merz ,A., Rushton, M.D., Charles, M., Jurk, D., Tait, S.W., Czapiewski, R., Greaves, L., Nelson, G., Bohlooly-Y., M., Rodriguez-Cuenca, S., Vidal-Puig, A., Mann, D., Saretzki, G., Quarato, G., Green, D.R., Adams, P.D., von Zglinicki, T., Korolchuk, V.I., and Passos, J.F. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J. 35, 724-742, 2016.
518. Lopez, J., Bessou, M., Riley, J.S., Giampazolias, E., Todt, F., Rochegüe, T., Oberst, A., Green, D.R., Edlich, F., Ichim, G., and Tait, S.W. Mito-priming as a method to engineer Bcl-2 addiction. Nat Commun. 7, 10538, 2016.
519. Liu, L., Lu, Y., Martinez, J., Bi, Y., Lian, G., Wang, T., Milasta, S., Wang, J., Yang, M., Liu, G., Green, D.R., and Wang, R. Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent. Proc Natl Acad Sci U S A. 113, 1564-1569, 2016.
520. Wei, J., Long, L., Yang, K., Guy, C., Shrestha, S., Chen, Z., Wu, C., Vogel, P., Neale, G., Green, D.R., and Chi, H. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat Immunol. 17, 277-285, 2016.
521. Martinez, J., Cunha, L.D., Park, S., Yang, M., Lu, Q., Orchard, R., Li, Q.Z., Yan, M., Janke, L., Guy, C., Linkermann, A., Virgin, H.W., and Green, D.R. Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. Nature. 533, 115-119, 2016.
522. Dillon, C.P., Tummers, B., Baran, K., and Green, D.R. Developmental checkpoints guarded by regulated necrosis. Cell Mol Life Sci. 2016 Apr 7. [Epub ahead of print]
523. Wallach, D., Kang, T.B., Dillon, C.P., and Green, D.R. Programmed necrosis in inflammation: Toward identification of the effector molecules. Science. 2016 352(6281):aaf2154. doi: 10.1126/science.aaf2154.
524. Green, D.R., Oguin, T.H., and Martinez, J. The clearance of dying cells: table for two. Cell Death Differ. 23, 915-926, 2016.
525. Goodall, M.L., Fitzwalter, B.E., Zahedi, S., Wu, M., Rodriguez, D., Mulcahy-Levy, J.M., Green, D.R., Morgan, M., Cramer, S.D., and Thorburn, A. The autophagy machinery controls cell death switching between apoptosis and necroptosis. Dev Cell. 7, 337-349, 2016.
526. Lin, X., Pelletier, S., Gingras, S., Rigaud, S., Maine, C.J., Marquardt, K., Dai, Y.D., Sauer, K., Rodriguez, A.R., Martin, G., Kupriyanov, S., Jiang, L., Yu, L., Green, D.R., and Sherman, L.A. CRISPR-Cas9 mediated modification of the NOD mouse genome with Ptpn22R619W mutation increases autoimmune diabetes. Diabetes. 65, 2134-2138, 2016.
527. Joo, J.H., Wang, B., Frankel, E., Ge, L., Xu, L., Iyengar, R., Li-Harms, X., Wright, C., Shaw, T.I., Lindsten, T., Green, D.R., Peng, J., Hendershot, L.M., Kilic, F., Sze, J.Y., Audhya, A., and Kundu, M. The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. Mol Cell. 62, 491-506, 2016.
528. Devaraju, P., Yu ,J,. Eddins, D., Mellado-Lagarde, M.M., Earls, L.R., Westmoreland, J.J., Quarato, G., Green, D.R., and Zakharenko, S.S. Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium. Mol Psychiatry. 2016 May 17. doi: 10.1038/mp.2016.75. [Epub ahead of print]
529. Chu, H., Khosravi, A., Kusumawardhani, I., Kwon, H.K., Shen, Y., Vasconcelos, A., Dias da Cunha, L., Xavier, R.J., Ernst, P.B., Green, D.R., McGovern, D.P., Virgin, H.W., and Mazmanian, S.K. Microbiota promote mucosal tolerance via genetic pathways linked to inflammatory bowel disease. Science, 352, 1116-1120, 2016.
530. Nogusa, S., Thapa, R.J., Dillon, C.P., Liedmann, S., Oguin T.H., Ingram, J.P., Rodriguez, D.A., Kosoff, R., Sharma, S., Sturm, O., Verbist, K., Gough, P.J., Bertin, J., Hartmann, B.M., Sealfon, S. C., Kaiser, W. J., Mocarski, E.S., Lopez, C.B., Thomas, P.G., Oberst, A., Green, D. R., and Balachandran, S. (shared senior authorship) RIPK3 activates parallel pathways of MLKL- driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus. Cell Host Microbe, 20, 13-24, 2016.
531. Alvarez-Diaz, S., Dillon, C.P., Lalaoui, N., Tanzer, M.C., Rodriguez, D.A., Lin, A., Lebois, M.,
Hakem, R., Josefsson, E.C., O’Reilly, L.A., Silke, J., Alexander, W.S., Green, D.R., and Strasser, A. (shared senior authorship). MLKL promotes embryonic lethality caused by loss of Caspase-8 or FADD and their combined absence causes fatal lymphadenopathy and autoimmune disease. Immunity, 45, 513-526, 2016.
532. Green, D.R., and Fitzgerald, P. Just so stories about the evolution of apoptosis. Curr. Biol., 26, R620-R627, 2016.
533. Gautheron, J., Vucur, M., Schneider, A.T., Severi, I., Roderburg, C., Roy, S., Bartneck, M., Schrammen, P., Diaz, M.B., Ehling, J., Gremse, F., Heymann, F., Koppe, C., Lammers, T., Kiessling, F., Van Best, N., Pabst, O., Courtois, G., Linkermann, A., Krautwald, S., Neumann, U.P., Tacke, F., Trautwein, C., Green, D.R., Longerich, T., Frey, N., Luedde, M., Bluher, M., Herzig, S,. Heikenwalder, M., and Luedde, T. The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance. Nat Commun. 7, 11869, 2016.
534. Dillon, C.P., and Green, D.R. Molecular cell biology of apoptosis and necroptosis in cancer. Adv Exp Med Biol. 930, 1-23, 2016.
535. Gilchuk, P., Hill, T.M., Guy, C., McMaster, S.R., Boyd, K.L., Rabacal, W.A., Lu, P., Shyr, Y., Kohlmeier, J.E., Sebzda, E., Green, D.R., and Joyce, S. A distinct lung-interstitium-resident memory CD8+ T cell subset confers enhanced protection to lower respiratory tract infection. Cell Rep. 16,1800-1809, 2016.
536. Kamiński, M.M., Liedmann, S., Milasta, S., and Green, D.R. Polarization and asymmetry in T cell metabolism. Semin Immunol., 28, 525-534, 2016.
537. Peterson, L.W., Philip, N.H., Dillon, C.P., Bertin, J., Gough, P.J., Green, D.R., and Brodsky, I.E. Cell-extrinsic TNF collaborates with TRIF signaling To promote Yersinia-induced apoptosis. J Immunol., 197, 4110-4117, 2016.
538. Weinlich, R., Oberst, A., Beere, H.M., and Green, D.R. Necroptosis in development, inflammation and disease. Nat Rev Mol Cell Biol. 18, 127-136, 2017.
539. Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., Green, D.R., Dorstyn, L., Kumar, S. Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene 36, 2704-2714, 2017.
540. Green, D.R. Cancer and apoptosis: Who is built to last? Cancer Cell, 31, 2-4, 2017.
541. Gong, Y., Guy, C. Olauson, H., Becker, J.U., Yang, M., Fitzgerald, P., Linkermann, A., and Green, D.R. ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences. Cell, 169, 286-300, 2017.
542. Tummers, B., and Green, D.R. Caspase-8: regulating life and death. Immunol Rev. 277, 76-89. 2017.
543. Green, D.R. Cell death and the immune system: getting to how and why. Immunol Rev. 77, 4-8, 2017.
544. Qi, X., Gurung, P,, Malireddi, R.K,, Karmaus, P.W., Sharma ,D., Vogel, P., Chi, H., Green, D.R., and Kanneganti, T.D. Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunol. 10, 128-138, 2017.
545. Peterson, L.W., Philip, N.H., Dillon, C.P., Bertin, J., Gough, P.J., Green, D.R., and Brodsky, I.E. Cell-extrinsic TNF collaborates with TRIF signaling to promote Yersinia-induced apoptosis. J Immunol. 197, 4110-4117, 2017.
546. Matte-Martone, C., Liu, J., Zhou, M., Chikina, M., Green, D.R., Harty, J.T., and Shlomchik, W.D.. Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus- leukemia resistance and sensitivity. J Clin Invest. 127, 2765-2776, 2017.
547. Smallwood, H.S., Duan, S., Morfouace. M., Rezinciuc, S., Shulkin, B.L., Shelat, A., Zink, E.E., Milasta, S., Bajracharya, R., Oluwaseum, A.J., Roussel, M.F., Green, D.R., Pasa-Tolic, L., and Thomas, P.G.. Targeting metabolic reprogramming by influenza infection for therapeutic intervention.. Cell Rep. 2017 May 23;19(8):1640-1653, 2017.
548. Galluzzi, L., Bravo-SanPedro, J.M., Levine, B., Green D.R., and Kroemer, G. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat Rev Drug Discov. 2017 May 19. doi: 10.1038/nrd.2017.22. [Epub ahead of print]
549. Tummers B., and Green, D.R. RIPped for neuroinflammation. Cell Res. 27, 1074, 2017.
550. Baran, K., Yang, M., Dillon, C.P., Samson, L.L., and Green, D.R. The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage. Cell Death Differ. 2017. doi: 10.1038/cdd.2017.116. [Epub ahead of print]
551. Yang, J., Milasta, S., Hu, D., AlTahan, A.M., Interiano, R.B., Zhou, J., Davidson, J., Low, J., Lin, W., Bao, J., Goh, P., Nathwani, A.C., Wang, R., Wang, Y., Ong, S.S., Boyd, V.A., Young, B., Das, S., Shelat, A., Wu, Y., Li, Z., Zheng, J.J., Mishra, A., Cheng, Y., Qu, C., Peng, J., Green, D.R., White, S., Guy, R.K., Chen, T., and Davidoff, A.M. Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Res. 2017 Jul 6. doi: 10.1158/0008- 5472.CAN-16-0826. [Epub ahead of print]
552. Boege, Y., Malehmir, M., Healy, M.E., Bettermann, K., Lorentzen, A., Vucur, M., Ahuja, A.K., Böhm, F., Mertens, J.C., Shimizu, Y., Frick, L., Remouchamps, C., Mutreja, K., Kähne, T., Sundaravinayagam, D., Wolf, M.J., Rehrauer, H., Koppe, C., Speicher, T., Padrissa-Altés, S., Maire, R., Schattenberg, J.M., Jeong, J.S., Liu L, Zwirner, S., Boger, R., Hüser, N., Davis, R.J., Müllhaupt, B., Moch, H., Schulze-Bergkamen, H., Clavien, P.A., Werner, S., Borsig, L., Luther, S.A., Jost, P.J., Weinlich, R., Unger, K., Behrens, A., Hillert, L., Dillon, C., Di Virgilio, M., Wallach, D., Dejardin, E., Zender, L., Naumann, M., Walczak, H., Green, D.R., Lopes, M., Lavrik, I., Luedde, T., Heikenwalder, M., and Weber, A. A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development. Cancer Cell 32,342-359, 2017.
553. Chang, T.C., Carter, R.A., Li, Y., Li, Y., Wang, H., Edmonson, M.N., Chen, X., Arnold, P., Geiger, T.L., Wu, G., Peng, J., Dyer, M., Downing, J.R., Green, D.R., Thomas, P.G., and Zhang, J. The neoepitope landscape in pediatric cancers. Genome Med. 9,78, 2017.
554. Gong, Y.N., Guy, C., Crawford, J.C., and Green. D.R. Biological events and molecular signaling following MLKL activation during necroptosis. Cell Cycle. 30, 1-13, 2017.
555. Heckmann, B.L., Boada-Romero, E., Cunha, L.D., Magne, J., and Green, D.R. LC3-Associated Phagocytosis and Inflammation. J Mol Biol. 429, 3561-3576, 2017.
556. Peterson, L.W., Philip, N.H., DeLaney, A., Wynosky-Dolfi, M.A., Asklof, K., Gray, F., Choa, R., Bjanes, E, Buza, E.L., Hu, B., Dillon, C.P., Green, D.R., Berger, S.B., Gough, P.J., Bertin, J., and Brodsky. I.E. RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense. J Exp Med. 214, 3171-3182, 2017.
557. Wu, X., Zhang, L.S., Toombs, J., Kuo, Y.C., Piazza, J.T., Tuladhar. R., Barrett, Q., Fan, C.W., Zhang, X., Walensky, L.D., Kool, M., Cheng, S.Y., Brekken, R., Opferman, J.T., Green, D.R., Moldoveanu, T., Lum, L. Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nat Cell Biol. 19, 1226-1236, 2017.
558. Kalkavan, H., and Green, D.R. MOMP, cell suicide as a BCL-2 family business. Cell Death Differ. 25, 46-51, 2017.
559. Moretti, J., Roy, S., Bozec, D., Martinez, J., Chapman, J.R., Ueberheide, B., Lamming, D.W., Chen, Z.J., Horng, T., Yeretssian, G., Green, D.R., and Blander, J.M. STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell, 171, 809-823, 2017.
560. Wang, B., Iyengar, R., Li-Harms, X., Joo, J.H., Wright, C., Lavado, A., Horner, L., Yang, M., Guan, J.L., Frase, S., Green, D.R., Cao, X., and Kundu, M. The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy, 2017 Nov 3:0. doi: 10.1080/15548627.2017.1386820. [Epub ahead of print].
561. Gabriel Mitchell, G., Cheng, M.I., Chen, C., Nguyen, B.N., Whiteley, A.T., Kianian, S., Cox, J.S., Green, D.R., McDonald, K.L., and Portnoy, D.A. Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy. Proc. Natl. Acad. Sci., 115, E210-217, 2017.
562. He, H., Wang, J., Wang, H., Zhou, N., Yang, D., Green, D.R., and Xu, B. Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria. J Am Chem Soc. 140, 1215-1218, 2018.
563. von Mässenhausen, A., Tonnus, W., Himmerkus, N., Parmentier, S., Saleh, D., Rodriguez, D., Ousingsawat, J., Ang, R.L., Weinberg, J.M., Sanz, A.B., Ortiz, A., Zierleyn, A., Becker, J.U., Baratte, B., Desban, N., Bach, S., Schiessl, I.M., Nogusa, S., Balachandran, S., Anders, H.J., Ting, A.T., Bleich, M., Degterev, A., Kunzelmann, K., Bornstein, S.R., Green, D.R., Hugo, C., and Linkermann, A. Phenytoin inhibits necroptosis. Cell Death Dis. 9, 359, 2018.
564. Follis, A.V., Llambi, F., Kalkavan, H., Yao, Y., Phillips, A.H., Park, C.G., Marassi, F.M., Green, D.R., and Kriwacki, R.W. Regulation of apoptosis by an intrinsically disordered region of Bcl- xL. Nat. Chem. Biol. 14, 458-465, 2018.
565. Green, D.R. Eating the beast: Dietary protein and anti-cancer immunity. Cell Metab. 27, 703- 705, 2018.
566. Cunha, L.D, Yang, M., Carter, R., Guy, C., Harris, L., Crawford, J., Quarato, G., Boada-Romero, E., Kalkavan, H., Johnson, M.D., Natarajan, S., Turnis, M.E., Finkelstein, D., Opferman, J.T.,, Gawad, C., and Green, D. R.. Regulation of myeloid function by LC3-associated phagocytosis promotes tumor immune tolerance. Cell, 175, 429-441, 2018.
567. Lian, G., Gnanaprakasam, J.R., Wang, T., Wu, R., Chen, X., Liu, L., Shen, Y., Yang, M., Yang, J., Chen, Y., Vasiliou, V., Cassel, T.A., Green, D.R., Liu, Y., Fan, T., Wang, R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10;7. pii: e36158. doi: 10.7554/eLife.36158. [Epub ahead of print]
568. Sung, B., Su, Y., Jiang, J., Mcleod, P., Liu, W., Haig, A., Green, D.R., Zhang, Z.X., Jevnikar, A.M. Loss of RIPK3 and Caspase-8 Augments Intrinsic Apoptosis in Tubular Epithelial Cell and promote Kidney Ischemia Reperfusion Injury. Nephrology (Carlton). 2018 Sep 3. doi: 10.1111/nep.13487. [Epub ahead of print]
569. McNamara, D.E., Quarato, G., Guy, C.S., Green, D.R., and Moldoveanu, T. Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis. J Vis Exp. 2018 Aug 7;(138). doi: 10.3791/58088.
570. Rodriguez, D.A., and Green, D.R. Generation and Use of Chimeric RIP Kinase Molecules to Study Necroptosis. Methods Mol Biol. 1857, 71-83, 2018.
Books and Volumes
1. Kaplan, J.G., Green, D.R. and Bleakley, R.C. (editors). Cellular Basis of Immune Modulation, Progress in Leukocyte Biology Vol. 9, New York:Alan R. Liss, 1989.
2. Faist, E., Ninnemann, J., and Green, D. (editors). The Immune Consequences of Shock, Trauma, and Sepsis, Springer-Verlag, Berlin, 1989.
3. Golub, E.S., and Green, D.R. Immunology: A Synthesis, 2nd edition. Sinauer Press, Sunderland, 1991.
4. Green, D.R. (editor) Apoptosis in the Immune System. Sem. Immunol. V. 4. Saunders Scientific Pub., 1992.
5. Green, D.R. (section editor) Section 21, Apoptosis. In L.A. Herzenberg, D.M. Weir, L.A. Herzenberg, and C. Blackwell (eds). Handbook of Experimental Immunology, 5th Edition, Vol. 3. Blackwell Science, Cambridge, 1996.
6. Henderson, C.E., Green, D., Mariani, J., and Christen, Y. (editors). Neuronal Death by Accident or by Design. Springer-Verlag, Berlin. 2001.
7. Green, D.R. (guest editor) Apoptotic Pathways in the Immune System. Immunol. Rev. Vol. 193. Blackwell Munskgard. 2003.
8. Green, D.R. (guest editor) Apoptosis in the Development and Function of the Immune System. Semin. Immunol. V. 15, pp. 121-199. 2003.
9. Green, D.R., and Kroemer, G. (guest editors) Pharmacologic Manipulation of Cell Death. J. Clin. Invest. 115, 2610-2688, 2005.
10. Green, D.R., and Reed, J.C. (editors) Apoptosis: Physiology and Pathology of Cell Death, Cambridge University Press, Cambridge, 2011.
11. Green, D.R. Means to an End. Apoptosis and Other Cell Death Mechanisms. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2011.
12. Green, D.R. (guest editor) Immunometabolism. Sem. Immunol., V. 24, 2012.
13. Baehrecke, E.H., Green, D.R., Kornbluth, S., and Salvesen, G.S. (editors) Cell Survival and Cell Death. Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 2013.
14. Green, D.R. (editor) Cell death in the immune system. Immunol. Rev. Vol. 77, 2017.
15. Green, D.R. Means to an End: Apoptosis and Other Cell Death Mechanisms. Second Edition. Cold Spring Harbor Press. 2018. In press.
Other (Book Reviews, letters, editorials)
1. Green, D.R. Review of Developmental Biology: A Comprehensive Synthesis. Quart. Rev. Biol., 65, 356-357, 1990.
2. Green, D.R. Cell death and immunity. (Review of C.A. Gregory, ed. Apoptosis and the Immune Response). Science, 269, 861-862, 1995.
3. Green, D.R., and Beere, H.M. Apoptosis (poster). Immunol. Today, December, 1998.
4. Firestein, G.S., Zvaifler, N.J., and Green, D.R. p53 mutations in rheumatoid arthritis; Response to Kawai, et al., Arthritis Rheum, 43:469-70, 2000.
5. Melino G, Knight RA and Green DR. Publications in Cell Death: the golden age. Cell Death Differ, 8, 1-5, 2001.
6. Green, D.R. and Melino, G. ICE heats up. Cell Death Diff., 8, 549-550, 2001.
7. Ferguson, T.A., and Green, D.R. Fas-ligand and immune privilege: The eyes have it. Cell Death Differ. 8, 771-772, 2001.
8. Green, D.R. Apoptosis and elephants (Review of M.D. Jacobson and N. McCarthy, ed. Apoptosis, the molecular biology of programmed cell death). Trends Cell Biol., 12, 539-540, 2002. Also published in TIBS, 27, 590-592, 2002.
9. Beere, H. and Green, D.R. Apoptosis and Disease (Poster). TIBS, Trends Cell Biol., March 2003; Trends Immunol., Drug Disc. Today, April 2003.
10. Green DR, Knight RA, Melino G, Finazzi-Agro' A, and Orrenius S. Ten years of publication in cell death. Cell Death Differ., 11,2-3, 2004.
11. Green, D.R. Early work on the role of mitochondria, an interview with Doug Green. Cell Death Differ., 11, Suppl 2:S119-S121, 2004.
12. Green, D.R., Melino, G. Apoptotic gene therapy in the interdigital web. Cell Death Differ. 12, 410, 2005
13. Bender CE, Spierings DCJ, McStay GP, Chipuk JE, Saleh M, Maurer U, Green DR. Mitochondrial pathway of apoptosis: anti-apoptotic Bcl-2 family. Science STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/stkecm;CMP_17525.
14. Bender CE, Spierings DCJ, McStay GP, Chipuk JE, Saleh M, Maurer U, Green DR. Mitochondrial pathway of apoptosis: multidomain Bcl-2 family. Science STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18015.
15. Bender CE, Spierings DCJ, McStay GP, Chipuk JE, Saleh M, Maurer U, Green DR. Mitochondrial pathway of apoptosis: BH3 only Bcl-2 Family. Science STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18017.
16. Bender CE, Spierings DCJ, McStay, GP, Chipuk JE, Saleh M, Maurer U and Green DR. Mitochondrial Pathway of Apoptosis: Caspases. Science STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18019.
17. Green, D.R. Apoptosis in mammals. In: Apoptosis. Henry Stewart Talks. 2007
18. Green, D.R. The mitochondrial pathway of apoptosis, In: Mitochondria. Henry Stewart Talks. 2007.
19. Chipuk, J.E., Green, D.R. Response to Callus et al on 'Cytoplasmic p53 is not required for PUMA-induced apoptosis'. Cell Death Differ., 15, 215-216, 2008
20. Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E.S., Baehrecke, E.H., Blagosklonny, M.V., El-Deiry, W.S., Golstein, P., Green, D.R., et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 16, 3-11, 2009. PMCID: PMC2744427
21. Green, D.R. April fish. Oncogene, 28, 1569, 2009.
22. Gulluzzi, L., et al., Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ., 16, 1093-1107, 2009.
23. Green, D.R. Stress in biomedical research: Six impossible things. Mol. Cell, 40, 176-178, 2010.
24. Green, D.R. Opinion: Success! The Scientist, Dec 21, 2010
25. Green, D.R. Opinion: Six impossible things. The Scientist, Jan. 4, 2011
26. Green, D.R. “Tit for tat” in cell biology. Nat. Rev. Mol. Cell Biol. 12, 73, 2011.
27. Kroemer, G., Martinon, F., Lippens, S., Green, D.R., Knight, R., Vandenabeele, P., Piacentini, M., Nagata, S., Borner, C., Simon, H.U., Krammer, P., and Melino, G. Jurg Tschopp-1951-2011-an immortal contribution. Cell Death Differ 18, 1087-1088, 2011. PMID: 21527939
28. Galluzzi, L., et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ., 19, 107-120, 2012.
29. Green, D.R. Metabolism and immunity: The old and the new. Sem. Immunol., 24, 383, 2012.
30. Bendall, L.J., and Green, DR. Autopsy of a cell. Leukemia. In press.
31. McStay, G.P., and Green, D.R. Detection of caspase activity using antibody-based techniques. Cold Spring Harb Protoc. 2014, 783-788, 2014.
32. McStay, G.P., and Green, D.R. Assaying caspase activity in vitro. Cold Spring Harb Protoc. 2014, 774-777, 2014.
33. McStay, G.P., and Green, D.R.Preparation of cytosolic extracts and activation of caspases by cytochrome c. Cold Spring Harb Protoc. 2014, 778-782, 2014.
34. McStay GP, Green DR. Measuring apoptosis: caspase inhibitors and activity assays. Cold Spring Harb Protoc. 2014 ,799-806, 2014.
35. McStay GP, Green DR. Verification of a putative caspase substrate. Cold Spring Harb Protoc. 2014, 861-864, 2014.
36. McStay GP, Green DR. Identification of active caspases using affinity-based probes. Cold Spring Harb Protoc. 2014, 856-860, 2014.
37. Galluzzi, L., et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Diff., 22, 58-73, 2015.
38. Klionsky, D.L., et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12, 1-222, 2016.
39. Green, D.R. A BH3-mimetic for killing cancer cells. Cell, 165, 1560, 2016.
40. Galluzzi L, et al., Molecular definitions of autophagy and related processes. EMBO J. 2017 Jun 8. pii: e201796697. doi: 10.15252/embj.201796697. [Epub ahead of print]
41. Tummers, B., and Green, D.R.. RIPped for neuroinflammation.. Cell Res. 2017 May 19. doi: 10.1038/cr.2017.71. [Epub ahead of print]
42. Green, D.R. Carmine Melino. Ann Ig. 29, 382-383, 2017.
43. Galluzzi, L., et al. Molecular definitions of autophagy and related processes. EMBO J. 36, 1811- 1836, 2017.
44. Galluzzi L, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Jan 23. doi: 10.1038/s41418-017-0012-4. [Epub ahead of print]
D.R. Green has also published over 100 essays in the “Mole and Friends” column in the Journal of Cell Science, under the pseudonym, “The Mole.”
Patents
1. D.R. Green and T.G. Cotter. Enhancement of apoptosis using antisense oligonucleotides. US Patent No. 5,583,034. Application Serial No. 08/200,723. Filed, Feb. 22, 1994. Issue Date, Dec. 10, 1996. (Ref. PD-2172)
2. Firestein, G., Zvaifler, N., and Green, D.R. Methods for treating arthritis by administering an apoptosis regulator. U.S. Patent no. 6,004,942. Filed, Aug. 30, 1996; Issued, Dec. 21, 1999.
3. Kasibhatla, S., Green, D.R., Tseng, B. Method of identifying immunsuppressive agents. Filed: Aug. 2, 2001.
4. Wang, Y., Cai, X., Weber, E., Mills, G.B., Green, D.R., and Guan, L. Substituted alpha-hydroxyl acid caspase inhibitors and the use thereof. US Patent no., 6, 495, 522. Issue Date, Dec. 17, 2002.