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The Rapid Synthesis of Oxazolines and Their Heterogeneous Oxidation to Oxazoles Under flow Cite This: Org
Organic & Biomolecular Chemistry View Article Online PAPER View Journal | View Issue The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow Cite this: Org. Biomol. Chem., 2015, 13, 207 conditions† Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio and Steven V. Ley* Received 2nd October 2014, A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The Accepted 27th October 2014 oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereo- DOI: 10.1039/c4ob02105c chemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be www.rsc.org/obc obtained via a packed reactor containing commercial manganese dioxide. 12 13 peroxide or O2 gas have also been successfully employed, Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Introduction although largely for the oxidation of C5-unsubstituted oxazo- Oxazolines and oxazoles are important biological scaffolds line rings. While manganese(IV) dioxide (MnO2) has been present within many natural products (Fig. 1).1,2 Amongst the applied with some success to the preparation of thiazoles many synthetic approaches towards these structural motifs, from thiazolidines,14 to date it has not been widely used for one very useful strategy involves the cyclodehydration of the synthesis of oxazoles and only a few examples exist in the β-hydroxy amides using reagents such as Burgess’ reagent,3 literature.15,16 4 5 6 the Mitsunobu reagent, Martin sulfurane, Ph2-SO-Tf2O, We have previously described the preparation of oxazolines 7 9 PPh3-CCl4 or by treatment with fluorinating reagents such as in flow during the synthesis of o-methyl siphonazole, hennox- 8 17 18 This article is licensed under a diethylaminosulfur trifluoride (DAST) and Deoxo-Fluor®. -
MS 315 A1076 Papers of Clemens Nathan Scrapbooks Containing
1 MS 315 A1076 Papers of Clemens Nathan Scrapbooks containing newspaper cuttings, correspondence and photographs from Clemens Nathan’s work with the Anglo-Jewish Association (AJA) 1/1 Includes an obituary for Anatole Goldberg and information on 1961-2, 1971-82 the Jewish youth and Soviet Jews 1/2 Includes advertisements for public meetings, information on 1972-85 the Middle East, Soviet Jews, Nathan’s election as president of the Anglo-Jewish Association and a visit from Yehuda Avner, ambassador of the state of Israel 1/3 Including papers regarding public lectures on human rights 1983-5 issues and the Nazi war criminal Adolf Eichmann, the Middle East, human rights and an obituary for Leslie Prince 1/4 Including papers regarding the Anglo-Jewish Association 1985-7 (AJA) president’s visit to Israel, AJA dinner with speaker Timothy Renton MP, Minister of State for the Foreign and Commonwealth Office; Kurt Waldheim, president of Austria; accounts for 1983-4 and an obituary for Viscount Bearsted Papers regarding Nathan’s work with the Consultative Council of Jewish Organisations (CCJO) particularly human rights issues and printed email correspondence with George R.Wilkes of Gonville and Cauis Colleges, Cambridge during a period when Nathan was too ill to attend events and regarding the United Nations sub- commission on human right at Geneva. [The CCJO is a NGO (Non-Governmental Organisation) with consultative status II at UNESCO (the United National Education, Scientific and Cultural Organisation)] 2/1 Papers, including: Jan -Aug 1998 arrangements -
Professor Binne Zwanenburg a Tribute
Issue in Honor of Prof. Binne Zwanenburg ARKIVOC 2004 (ii) 1-3 Professor Binne Zwanenburg A Tribute I cannot think of an instance, at least one of which I was aware, in the unique world of Dutch chemistry (every country has its own idiosyncrasies) when an important decision was in the air that someone did not ask "what does Binne think about this?". And I cannot remember an instance in which the position of Binne, if not yet known, was not soon made so. Binne Zwanenburg has given greatly to chemistry in general by outstanding scientific contributions and to Dutch chemistry in particular in the form of enormous and creative personal insight. Binne Zwanenburg was born in 1934 in Lippenhuizen in the province of Friesland. He grew up as a native speaker of Frisian and still has an admirable facility with this dialect (Frisians are of the opinion, not without reason, that this is a true language both spoken and written). He received his Ph.D degree in 1962 at the University of Groningen under the supervision of Wiendelt Drenth, who was later to become professor in Utrecht. He had postdoctoral positions with Ralph Raphael at Glasgow in 1963 and with Nelson Leonard at the University of Illinois in 1964/1965. He was appointed associate professor at the University of Groningen in 1965. During the period in Groningen, Binne Zwanenburg began work on organosulfur compounds in particular sulfines as well as on functionalized small-ring heterocycles. In addition to this chemistry, which quickly drew international attention, Binne became deeply involved with the plans for a new chemistry building in Groningen. -
Financial Statements and Trustees' Report 2017
Royal Society of Chemistry Financial Statements and Trustees’ Report 2017 About us Contents We are the professional body for chemists in the Welcome from our president 1 UK with a global community of more than 50,000 Our strategy: shaping the future of the chemical sciences 2 members in 125 countries, and an internationally Chemistry changes the world 2 renowned publisher of high quality chemical Chemistry is changing 2 science knowledge. We can enable that change 3 As a not-for-profit organisation, we invest our We have a plan to enable that change 3 surplus income to achieve our charitable objectives Champion the chemistry profession 3 in support of the chemical science community Disseminate chemical knowledge 3 and advancing chemistry. We are the largest non- Use our voice for chemistry 3 governmental investor in chemistry education in We will change how we work 3 the UK. Delivering our core roles: successes in 2017 4 We connect our community by holding scientific Champion for the chemistry profession 4 conferences, symposia, workshops and webinars. Set and maintain professional standards 5 We partner globally for the benefit of the chemical Support and bring together practising chemists 6 sciences. We support people teaching and practising Improve and enrich the teaching and learning of chemistry 6 chemistry in schools, colleges, universities and industry. And we are an influential voice for the Provider of high quality chemical science knowledge 8 chemical sciences. Maintain high publishing standards 8 Promote and enable the exchange of ideas 9 Our global community spans hundreds of thousands Facilitate collaboration across disciplines, sectors and borders 9 of scientists, librarians, teachers, students, pupils and Influential voice for the chemical sciences 10 people who love chemistry. -
The Case for Chemistry What Comes Next for Science Funding?
RSCNEWS JULY 2015 www.rsc.org The case for chemistry What comes next for science funding? A better future for Kibera p10 Chemophobia, a chemists’ construct p13 Students from 15 schools across the northwest attended the Basil McCrea MLA joins students at the Salters’ Festival event at Salters’ Festival event at Liverpool JMU. (© Matt Thomas) Queen’s University Belfast. (© Queen’s University Belfast) Students enjoy solving puzzles with chemistry at Aberystwyth Patiently waiting for results at Aberystwyth University. University. (© Centre for Widening Participation and Social (© Centre for Widening Participation and Social Inclusion, Inclusion, Aberystwyth University) Aberystwyth University) Aoife Nash and Maeve Stillman from St Mary’s College Derry at the Salters’ Festival of Chemistry at North West Regional College. (© North West Regional College) Flash and bang demo at Queen’s University Belfast. (© Queen’s University Belfast) Level 3 forensic science student Dillon Donaghey offers some advice to some Thornhill College pupils during the Salters’ Festival of Chemistry at North West Regional College. (© North West Regional College) See more about the Salters’ Festival on p19. WEBSITE Find all the latest news at www.rsc.org/news/ Contents JULY 2015 Editor: Edwin Silvester Design and production: REGULARS Vivienne Brar 4 Contact us: Snapshot 7 RSC News editorial office News and updates from around Thomas Graham House Science Park, Milton Road the organisation Cambridge, CB4 0WF, UK 6 Tel: +44 (0)1223 432294 One to one Email: [email protected] -
Chemistry Update Newsletter 287, 28Th July 2017
Chemistry Update Newsletter 287, 28th July 2017 Inside this Issue Calendar of Events York Chemistry Student YouTube Stars 2 Green Chemistry Seminar Understanding the Role of Nitrogen Oxides 3 Speaker: Professor Martin Atkins, Green Lizard in the Nocturnal Atmosphere Technologies Ltd / Queen's University Belfast York Chemistry PhD Student Awarded SCI 4 Date: Thursday 10 August Scholarship Time: 12pm-1pm Location: C/F/106 York Chemistry PhD Student Brings New Ideas to 5 Aviation Fluid Research ViCEPHEC17 Conference Javier Remon Nunez Awarded Thesis & Teaching 6 Date: 23-25 August Prizes Location: Department of Chemistry Medicinal Chemistry Resident School 11-16 June 7 Research Seminar 2017 Speaker: Masaaki Fujii , Helen Burrell Awarded Degree in Natural Tokyo Institute of Technology Sciences Date: Monday 28 August Time: 2pm-3pm Graduation 8 Location: C/A/128 KMS Prize Winners 9 Dr Glenn Hurst Presents at STEM Conference Postgraduate Research Careers Event 2017 10 University of York Annual Learning and Teaching 11 Conference 2017 Polar Solvents Promote Halogen Over Hydrogen Bonds Annual Staff Family Picnic and Rounders Match 12-13 Stonewall Allies Training Programme 14 We Escaped 15 New Starters 16 3rd EuGSC Conference Date of Next Issue: ViCEPHEC17 Conference 17 25th August 2017 York Chemistry Student YouTube Stars With over 175 videos on YouTube, first year York Chemistry Students have, over the past 7 years, created one of the most diverse sources of online educational material in the field of polymer chemistry. For the last 7 years, York Chemistry students have had the opportunity to make a YouTube video as part of their Year 1 assessments. -
NEWSLETTER Winter 2016-2017
NEWSLETTER winter 2016-2017 See ‘Meeting Report: Cheminformatics for Drug Design: Data, Models and Tools’, page 13 CICAG aims to keep its members abreast of the latest activities, services, and developments in all aspects of chemical information, from generation through to archiving, and in the computer applications used in this rapidly changing area through meetings, newsletters and professional networking. Chemical Information & Computer Applications Group: http://www.rsc.org/CICAG QR Code http://www.linkedin.com/groups?gid=1989945 MyRSC http://my.rsc.org/groups/cicag https://twitter.com/RSC_CICAG Table of Contents Chemical Information & Computer Applications Group Chair's Report 3 Undergraduate Research Bursaries - 2016 Report 3 Undergraduate Research Bursaries – CICAG Sponsorship in 2017 4 RSC CICAG Social Media 4 Open Source Malaria Project Data 6 Tony Kent Strix Award 7 Dalton anniversary celebration events, Manchester 9 RSC General Assembly Report 10 CICAG Planned and Proposed Future Meetings 13 Chemical Structure Representation: What Would Dalton Do Now? 14 1st Cambridge Information & Intellectual Property Training Events 15 11th International Conference on the History of Chemistry 15 Next Noordwijkerhout Meeting 16 RSC Chemistry Library - Reaxys and ScienceDirect 16 InfoChem News 17 CAS / SciFinder / STN News 17 CICAG Meeting Reports 19-28 • Chemistry on Mobile Devices 19 • Cheminformatics for Drug Design 25 Contributions to the CICAG Newsletter are welcome from all sources - please send to the Newsletter Editor: Stuart Newbold, email: [email protected] Chemical Information & Computer Applications Group Chair's Report Contributed by RSC CICAG Chair Dr Helen Cooke, email: [email protected] 2016 has seen the CICAG Committee working on a diversity of activities to support our members, including scientific meetings, sponsoring a student bursary and the Tony Kent Strix Award, building our social media presence. -
Azide Monoliths As Convenient Flow Reactors for Efficient Curtius
PAPER www.rsc.org/obc | Organic & Biomolecular Chemistry Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions† Marcus Baumann, Ian R. Baxendale, Steven V. Ley,* Nikzad Nikbin and Christopher D. Smith Received 29th January 2008, Accepted 15th February 2008 First published as an Advance Article on the web 12th March 2008 DOI: 10.1039/b801634h The preparation and use of an azide-containing monolithic reactor is described for use in a flow chemistry device and in particular for conducting Curtius rearrangement reactions via acid chloride inputs. Introduction due to their nature and format. By far the most common support systems for organic synthesis have been the gel-type polystyrene- In the preceding article we described a simple flow reactor for based resins7 or co-polymers thereof prepared as small beads performing Curtius rearrangements starting from carboxylic acids (defined by low crosslinking). The physical compressibility of with concomitant trapping of the intermediate isocyanate with these materials tends to obstruct the flow stream leading to large 1 various nucleophiles. In this paper we wish to further exemplify pressure drops, especially when used with thermodynamically this Curtius chemistry by using alternative monolithic reactor compatible ‘good’ solvents—solvents that effectively solvate and devices as immobilised azide sources for the conversion of acid swell the resins. Conversely, in the presence of a ‘poor’ solvent the chlorides. beads shrink, causing the active sites to become less accessible to Both traditional solution-phase and solid-phase synthetic ap- the reactants and enabling the reaction mixture to by-pass and proaches have associated problems and limitations. -
Chem@Cam Summer 2012 Reluctant Reactions Letters
Summer 2012 Investigating tandem repeat proteins Dynamic hydrogels and drug delivery Commercialising chemistry via spin-outs Enthusing kids at the chemistry open day As I see it... of the chips via an external manufacturer. Spin-out company Sphere Fluidics was set up to exploit Companies are able to do things that academic science carried out here in the department. Sarah Houlton groups don’t do in terms of making products, manufacturing and getting involved in a lot of talks to chief executive Frank Craig about how it’s going commercial activity. We now have all the expe - rience and skill sets, and a lot of innovations emulsion chemistry. To make an emulsion, have been turned into products and are being water and oil are mixed, and the water can be sold. We’ve learnt a lot in our time here, but it’s stabilised with surfactants to stop it separating. now time to go outside, where we will have There’s a lot of know-how in surfactant chem - more scope for industrial-scale activities and istry within the department, and thanks to significant growth. novel surfactants and leading-edge microflu - idics we can now carry out about a million sep - Is this the main reason why the best arate tests on a single chip, about the size of a route to commercialise a novel tech - postage stamp. nology within a university may be to The chip typically has three inlets. In one, spin out a company? there is a biological library of cells, another I think it’s a natural thing. -
A Digital Treasure Trove Opening up Our Historical Collection
RSCNEWS AUGUST 2015 www.rsc.org A digital treasure trove Opening up our historical collection A year in the life of our president p8 Far eastern frontiers p12 Bill Bryson Prize 2015 Winners and runners-up gathered at the Royal Society of Chemistry’s Burlington House to celebrate the brilliant creativity of this year’s entries. (See p5 for the full story). Emerging Tech winners David Fairen-Jimenez (pictured, centre) collects the Emerging Technologies final first prize in Materials for his University of Cambridge team’s idea of metal-organic frameworks manufacturing technology for gas storage. (See p4). Salters Festival fun rolls on 12 schools took part in the Salters Festival at Truro College – more than 120 primary students from local schools were fascinated by science, watching Peter Wright’s fantastic demonstrations, including lying on a bed of nails and a bin full of exploding teddy bears! WEBSITE Find all the latest news at www.rsc.org/news/ Contents AUGUST 2015 Editor: Edwin Silvester Design and production: REGULARS Vivienne Brar 4 Contact us: Snapshot 7 RSC News editorial office News and updates from around Thomas Graham House Science Park, Milton Road the organisation Cambridge, CB4 0WF, UK 6 Tel: +44 (0)1223 432294 One to one Email: [email protected] Book in for bespoke careers advice Burlington House, Piccadilly London W1J 0BA, UK 7 Tel: +44 (0)20 7437 8656 Profile Taff Morgan has worked on projects from the ice of Antarctica to the ice of @RSC_Newsroom comet 67P facebook.com/RoyalSocietyofChemistry 14 8 Opinion Photography: Your letters on qualifications and © Royal Society of Chemistry (cover public attitudes to chemistry and left) FEATURES 8 A year in the life.. -
Aerosol Particles and Lung Disease the Dynamics of Protein Systems
Spring 2009 Aerosol particles and lung disease The changing face of physical science The dynamics of protein systems Half a century in Lensfield Road As I see it... Former head of department Jeremy Sanders has a new role within the university – he’s now head of the school of physical sciences. He tells Sarah Houlton what the job entails What does the new job involve? research councils, channels a growing year since 2003! It’s hard to have the I am responsible for eight departments, amount of its research funding to areas really big strategic creative chemical which makes up about a fifth of the uni - that it deems to be important, be it cli - ideas now as I don’t spend enough time versity’s activities – chemistry, physics, mate change, energy, health related, or in serious thinking, but when someone earth sciences, material sciences, pure whatever. gives me results I can see the implica - maths, applied maths, astronomy and And the university needs to learn how tions and what the next step should be, geography – plus the Isaac Newton to manage these large research initia - because I can draw on more years of Institute for Mathematical Sciences. The tives in such a way that we retain the experience than I care to admit. And school is the layer between the central classic Cambridge freedom of the indi - there’s still no greater pleasure than sit - university administration and the indi - vidual to discover the unexpected, ting with a few of my group and being vidual departments. In the past, it was quirky, astonishing things that are trans - able to interpret an nmr spectrum better mainly a conduit for communication formational. -
Front Matter
Cambridge University Press 0521828732 - The 1702 Chair of Chemistry at Cambridge: Transformation and Change Edited by Mary D. Archer and Christopher D. Haley Frontmatter More information The 1702 Chair of Chemistry at Cambridge Transformation and Change The University of Cambridge’s 1702 Chair of Chemistry is the oldest continuously occupied chair of chemistry in Britain. The lives and work of the 1702 chairholders over the past three hundred years, described here, paint a vivid picture of chemistry as it slowly transformed from the handmaiden of alchemists and adjunct of medical men into a major academic discipline in its own right. The book has twelve chapters, covering all fifteen chairholders, from Giovanni Francesco Vigani, a contemporary and friend of Isaac Newton, through Smithson Tennant, discoverer of osmium and iridium, and Alexander Robertus Todd, Nobel Laureate and elucidator of the structure of key components of the double helix, to the current chairholder, master molecule maker Steven Victor Ley. Containing personal memoirs and historical essays by acknowledged experts, this book will engage all who are interested in the pivotal role chemistry has played in the making of the modern world. Mary Archer is a former fellow and lecturer in chemistry at Newnham College, Cambridge. She currently sits on the Chemistry Advisory Board and chaired the Tercentenary Steering Group in the Department of Chemistry at the University of Cambridge. Christopher Haley was formerly Archivist and Historian of the Department of Chemistry at the University of Cambridge. © Cambridge University Press www.cambridge.org Cambridge University Press 0521828732 - The 1702 Chair of Chemistry at Cambridge: Transformation and Change Edited by Mary D.