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Note Rapide #33 March 2020 NOTEL’INSTITUT PARISRAPIDE REGION #33 Sergey Nivens/Shutterstock.com Sergey ECONOMY March 2020 • www.institutparisregion.fr/en PARIS REGION: AT THE CUTTING EDGE OF BIOTECHNOLOGIES AND GENE & CELL THERAPIES PARIS REGION IS A HUB OF SCIENTIFIC EXCELLENCE AND FURTHERMORE HOME 1st in Europe TO NUMEROUS COMPETENCIES IN THE STRATEGIC SECTOR OF NEXT-GENERATION FOR THE NUMBER OF COMPANIES IN THE PHARMACEUTICALS SECTOR. BIOLOGICAL MEDICINES. PUBLIC-PRIVATE PARTNERSHIPS FOR BIOTHERAPY R&D BENEFIT GREATLY FROM THE PRESENCE OF LARGE BIOPHARMACEUTICAL GROUPS 250 IN THE REGION. HEALTH BIOTECH ENTITIES IN PARIS REGION. aris Region is Europe’s leader for the sciences and particularly notable for its multitude of actors in the health biotech sector, an aspect that illustrates the region’s attractiveness and More than 60 P competitiveness assets. The entire value chain is present: research, innovation, evaluation, ACADEMIC RESEARCH CENTERS production and commercialization, not to mention the formidable contributions to come as FOR THE DEVELOPMENT breakthroughs are made in the fields of informatics and artificial intelligence. OF BIOTECHNOLOGIES. INNOVATIVE THERAPIES: UNPRECEDENTED TREATMENTS AND EXPANDING MARKETS Biological medicines, or “biologics” for short, are a class of innovative therapies born of world-leading and highly promising fields of research, including novel antibodies (bispecifics), gene & cell therapies (advanced therapy medicinal products; ATMPs) and extracellular vesicles. With its investments in the field and the quality of its ecosystem, Paris Region plays a key role in biologics. The domain of innovative therapies is growing rapidly and achieving considerable breakthroughs in diagnostics, prognostics and treatments for rare brain (adrenoleukodystrophy, Parkinson’s disease, etc.) and blood (immunodeficiencies, beta thalassemia, hemophilia, etc.) pathologies, and for numerous cancers (lymphomas, etc.). Within and beyond the focus on rare diseases, there are currently more than 700 clinical trials underway in a broad range of specialties including dermatology, neurology, ophthalmology, oncology, metabolic medicine and infectious diseases (HIV). The stakes are large, both in terms of public health and for industry and the economy. Pharmaceutical groups, with their current R&D models running out of steam, their blockbuster revenue falling and their bottom lines being challenged by generics, are massively investing in these novel research directions and previously unexplored markets. Note rapide #33 March 2020 BIOTECHNOLOGY BIOTECHNOLOGIES AND INNOVATIVE THERAPIES: organism whose purpose is to strengthen innovation Biotechnology is defined by CORNERSTONE ASSETS FOR PARIS REGION capacities in a range of domains, including health. the Organisation for Economic Paris Region has numerous advantages: In September of 2019, the European Investment Co-operation and Development - Field-leading, public and private experts, teams Fund (EIF) and EIT Health signed a Memorandum (OECD) as “the application of science and technology to and infrastructures–particularly in the fields of of Understanding for the deployment of a co- living organisms as well as parts, biomarkers, genetic predisposition, biologics and investments program, called Venture Centre products and models thereof, nanobiotechnology1–notably federated in “major of Excellence EIF-EIT Health, to attract private to alter living or non-living interest domains” (DIM; domaines d’intérêt majeur) investments, particularly for biotech companies. materials for the production for gene therapies (DIM thérapie génique) and for At the EIT Health Summit held 3 December 2019, it of knowledge, goods and services.” new technological processes such as microfluidics was announced that Paris would host the piloting and extracellular vesicles (DIM ELICIT); team for the Venture Centre of Excellence program. - Several already-active centers of excellence (in Paris, Évry-Courcouronnes, Villejuif and Meary: an ATMP production center Paris-Saclay), which unite academic research, The Centre Meary de thérapie cellulaire et génique clinical research, business incubators and larger (Meary center for cell and gene therapies) is BIOINFORMATICS office+lab buildings (“hôtels d’entreprises”); integrated within the Paris network of public The OECD defines bioinformatics - A dense network of innovative start-ups and young hospitals (AP-HP), Europe’s largest university as “the construction businesses that are working synergistically with hospital center, and provides that institution with of databases on genomes, the numerous international pharmaceutical ATMP production capacities. With support from the protein sequences; modelling complex biological processes, groups also present in the territory. Paris Region region, the Centre Meary provides a full gamut of including systems biology.” leads Europe for the number of businesses in the state of the art services and competencies for the pharmaceuticals sector2; production, validation and distribution of gene & cell - Numerous research hospital centers for the and tissue engineering-derived therapies. preclinical and clinical evaluation of medical and therapeutic innovations; Within its healthcare and research ecosystem, - Numerous accompaniment, networking and the center’s kinetics for innovation have produced GENE THERAPY, valorization structures (Medicen Paris Region, EIT several world’s firsts. It furthermore has established CELL THERAPY Health, Satt, OTT, incubators) to facilitate access privileged relations with actors in the medical and Gene therapies treat genetic to the French and European markets; pharmaceutical industry. Centre Meary has the diseases by repairing - Bioproduction capacities (developed notably by expertise and means to accelerate the maturation of or replacing defective genes: such establishments as Centre Meary, Yposkesi, preclinical and clinical ATMP projects on all crucial functional genes are delivered to and inserted in (e.g., via CellforCure (Novartis) or LFB Biomedicaments) fronts: regulatory issues, automation, process retroviral vectors) the genomes able to ensure particularly complex medicines optimization, definition of ATMP specifications of affected cells to compensate manufacturing and industrialization processes, and quality control. The center has also developed for the dysfunctioning defective which represent a critical crossroad for the partnerships with Paris Region industrials working gene. The gene itself is the active development of innovative therapies. in the ATMP sector. These include Astraveus, a pharmaceutical ingredient of the medication. pioneer in microfluidics for the production of Cell therapy, also called Venture Centre of Excellence EIF-EIT ATMPs, Honing Biosciences a company developing regenerative medicine, uses to be piloted from Paris CAR-T cells3, MadeCell, which provides computer stem-cell-derived cell grafts Paris was chosen for the headquarters of EIT Health. programs specifically developed for ATMP to restore the function of tissues and organs damaged by disease, This latter is the health Knowledge and Innovation bioproduction activities, and Flash Therapeutics, a age or trauma. Community (KIC) of the European Institute of specialist in the production of viral vectors for gene Innovation and Technology (EIT), a European Union therapies. The health biotechnologies sector and associated businesses Businesses developing health products Human health products Preclinical & Research Industrialization clinical Bioproduction Regulatory Market access development submittals Mixed businesses Service businesses Services CROS; CMOs / CDMOs; bioinformatics; etc. © L’INSTITUT PARIS REGION 2020 Source: LEEM Note rapide #33 March 2020 Pontoise Cergy U. Cergy-Paris HEALTH BIOTECHNOLOGIES IN PARIS REGION Principal academic research centers (CRA) BUSINESSES AND PRINCIPAL RESEARCH CENTERS CRA Mantes-la-JolieIncubator Sarcelles CRA + Incubator VAL-D’OISE Screencell H CRA + Hospital I. R. Microbiologique H CRA + Incubator + Hospital Centre Meary: academic bioproduction center Argenteuil Single platform SEINE-SAINT-DENIS Saint-Denis Several platforms at a same site 1 Agoranov; 2 C.U. des Saints-Pères; 3 ENS Biologie; Bobigny SEINE-ET-MARNE 4 Sorbonne U. et CRC; 5 IPGG/ESPCI; 6 U. de Paris Biomillenia Stago Galapagos U. Paris-Nord Madecell Mitologics IRD Saint-Germain-en-Laye Pherecydes Biotech companies C.R. Inflammation Primadiag Takeda Celgene Parexel H Lilly H. Bichat Le Raincy Biotech or biotech services companies Nanterre PARIS Biocitech Lysogene H. St-Louis Servier C. Meary Vivet H Aenitis Gene & cell therapy companies Ab Science Novartis Biomunex (pure player or generalist) YVELINES Imagine CRI H. Necker 2 Torcy 10 6 I. Pasteur 15 13 14 8 Bioproduction site 17 1 7 HAUTS- H 4 H I. de la Vision Ip Research Onxeo 16 3 I. Curie I. de l’Audition 1 5 Gene & cell therapy companies DE- Janssen 2 5 Inria Nogent-sur-Marne 3 Nanobiotix ICM + bioproduction site I. Roche Amgen H Tech Care H 11 H 6 HEGP Paris H 9 I. de Myologie 12 Ineon 1 Theravectys; 2 Brainvectis; 3 Horama; 4 Hybrigenics; 5 Astraveus; SEINE Gilead PARCC I. Cochin 4 Cellectis iPEPS-ICM 6 Honing Biosciences; 7 Sparingvision; 8 Gensight; 9 Eyevensys; 10 Smart Immune; Pharnext Paris Biotech Santé ICAN Boulogne-Billancourt Pfizer H. Charles-Foix Theradiag 11 Everzom; 12 Pathoquest; 13 Alderaan; 14 Ermium Therapeutics; 15 Step Pharma; U. Versailles-SQY DNA Script H. Pitié-Salpêtrière HRA H H 16 Invectys; 17 Scarcell Pharma I. de Psychiatrie- Telomium Versailles
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