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Iron-Catalyzed Carboazidation of Alkenes and Alkynes

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Iron-Catalyzed Carboazidation of Alkenes and Alkynes ARTICLE https://doi.org/10.1038/s41467-018-07985-2 OPEN Iron-catalyzed carboazidation of alkenes and alkynes Haigen Xiong1,2, Nagarajan Ramkumar1, Mong-Feng Chiou1, Wujun Jian1, Yajun Li 1, Ji-Hu Su3, Xinhao Zhang 4 & Hongli Bao 1,2 Carboazidation of alkenes and alkynes holds the promise to construct valuable molecules directly from chemical feedstock therefore is significantly important. Although a few exam- 1234567890():,; ples have been developed, there are still some unsolved problems and lack of universal methods for carboazidation of both alkenes and alkynes. Here we describe an iron-catalyzed rapid carboazidation of alkenes and alkynes, enabled by the oxidative radical relay precursor t-butyl perbenzoate. This strategy enjoys success with a broad scope of alkenes under mild conditions, and it can also work with aryl alkynes which are challenging substrates for carboazidation. A large number of diverse structures, including many kinds of amino acid precursors, fluoroalkylated vinyl azides, other specific organoazides, and 2H-azirines can be easily produced. 1 Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, 350002 Fujian, China. 2 University of Chinese Academy of Sciences, 100049 Beijing, China. 3 Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics, CAS Key Laboratory of Microscale Magnetic Resonance, University of Science and Technology of China, 96 Jinzhai Road, 230026 Hefei, China. 4 Lab of Computational Chemistry and Drug Design, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, 518055 Shenzhen, China. Correspondence and requests for materials should be addressed to H.B. (email: [email protected]) NATURE COMMUNICATIONS | (2019) 10:122 | https://doi.org/10.1038/s41467-018-07985-2 | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-018-07985-2 mino acids, the basic building blocks of proteins are being radicals is limited, we found previously that in the presence of fi Aused increasingly in bio-relevant modi cation of proteins Fe(OTf)2 or Fe(OTf)3, the methyl radical is formed exclusively. and pharmaceutical applications. Development of more We envisioned that TBPB could serve as a polyfunctional reagent versatile methods to provide useful but synthetically challenging for the carboazidation of alkenes and alkynes. Herein, we report amino acid frameworks from chemical feedstocks is always our development of a versatile iron-catalyzed rapid carboazida- highly desired1–4. Carboazidation of alkenes and alkynes holds tion of both alkenes and alkynes, enabled by TBPB (Fig. 1c). the promise to construct valuable molecules including amino acid precursors and has therefore attracted much attention recently. Although several carboazidations of alkenes have been developed Results by Huang5, Renaud6,7, Liu8, Masson9, Zhu10, Jiao11 and Xu12, Carboazidation of alkenes. We investigated the reaction para- there are some unsolved problems in this field. How to realize the meters for carboazidation in the presence of TBPB and found fl fl carboazidation reaction using nontoxic, inexpensive and readily that ferrous tri uoromethanesulfonate (Fe(OTf)2, ferrous tri ate) available reagents with a broad scope of olefins remains a ques- is optimal (Fig. 2, see details in Supplementary Table 1 and tion. In addition, the carboazidation of alkynes is even more Supplementary Figures 2–4), delivering the corresponding pro- challenging than carboazidation of alkenes (Fig. 1a). There is duct 3 in 89% yield at rt with DME (dimethoxyethane) as 13 only one successful carboazidation of alkynes reported by Liu the solvent and azidotrimethylsilane (TMSN3) as the azidation which works for single carbon functionality, i.e., a trifluoromethyl reagent. Possible by-products 4, 4′, and 4″ were not observed. group using Togni’s reagent (Fig. 1b). The reason for the lack With the optimized conditions in hand, we studied the scope of methods for carboazidation of alkynes might be attributed to of the reaction with alkyl iodides (Fig. 3 and Supplementary the relative lower efficiency of incorporation of azido species Figures 5–34). Fluoroalkyl iodides were examined first and compared to other competing reactions. The development of the corresponding fluoroalkyl-azidation products (5–10) were carboazidation of alkenes and alkynes is significantly important obtained in high yields26. The reaction of styrene with from the synthetic point of view. iodoacetonitrile proceeds smoothly, affording the corresponding t-Butyl perbenzoate (TBPB) is a commercially available and product (11) in 86% yield. Reactions with ethyl iodoacetates inexpensive oxidant frequently used as a precursor of the affords products (12–14) with the yield ranging from 71–85%. – t-butoxyl radical14 22. Lately, TBPB has been proved to be a With 1-iodo-3,3-dimethylbutan-2-one the reaction delivers the good source of methyl radical by Yu23 and our group4,24,25. azide (15) in 61% yield. Three electron rich alkyl iodides, i.e., Although our understanding of the selective formation of methyl 1-chloro-4-iodobutane, 1-iododecane and 2-iodobutane are not a For alkenes b For alkynes 5 6,7 8 Huang, Renaud, Liu, Liu13 Masson, 9 Zhu, 10 Jiao,11 and Xu12 N3 N3 [Cu], Togni's reagent R [C] R R R CF3 Lack of general and comprehensive catalytic system c This work R1 2 Ar N R N 3 Fe(OTf) 3 R2 2 RI/TBPB Fe(OTf) 3 N 1 R TMSN Ar DME, rt 3 DME, rt Ar R R R 76 examples 25 examples Broad scope R = Rf, CH2CF3, mild conditions CH2CN, CH2CO2R, R = Rf, CF2CO2Et CH2COR multi-functionalization Alkenes Alkynes Fig. 1 Carboazidation of alkenes and alkynes. a Previous arts on carboazidation of alkenes. b Previous arts on carboazidation of alkynes. c This work: carboazidation of alkenes and alkynes 2 Fe(OTf) (5 mol%) R 2 R1 CF3 TBPB (2 equiv) + F C I +TMSN3 tBu 3 DME (2 mL) tBu F rt, 3 min 1a 2a 1 2 3, R = i-C3F7, R = N3,89% 1 2 0.5 mmol 2 equiv 2 equiv 4, R = Me, R = N3 4', R1 = Me, R2 = I 1 2 4'', R = i-C3F7, R = I Fig. 2 Optimized conditions for carboazidation of alkenes. Fe(OTf)2 (5 mol%), 1a (0.5 mmol), 2a (1.0 mmol), TMSN3 (1.0 mmol), TBPB (1.0 mmol) in DME (2 mL) at rt for 3 min under an N2 atmosphere 2 NATURE COMMUNICATIONS | (2019) 10:122 | https://doi.org/10.1038/s41467-018-07985-2 | www.nature.com/naturecommunications NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-018-07985-2 ARTICLE Fe(OTf)2 (5 mol%) N3 Ar TMSN3 (1.4–2.0 equiv) + I R R 1a, Ar = 4-tBu-Ph TBPB (2 equiv) Ar 1b, Ar = Ph 2 DME, rt N N3 3 ′ Rf R tBu 11b, R′ = CH CN, 86%, 10 min a 2 5 , Rf = CF , 87%, 20 min ′ 3 12, R = CH2CO2Et, 84%, 10 min 6, Rf = CF2CF3, 84%, 3 min ′ 13, R = CF2CO2Et, 85%, 3 min N3 ′ 14, R = CHFCO2Et, 71%, dr = 1:1, 3 min Rf′ N3 ′ 7, Rf = CF2CF2Cl, 87%, 3 min ′ O 8, Rf = n-C 4F9, 84%, 3 min ′ 9, Rf = cyc-C6F11, 93%, 3 min 15, 61%, 10 min ′ 10, Rf = CH2CF3, 70%, 30 min Cl RI= I I C7H15 I Trace Trace Trace Fig. 3 Scope of alkyl iodides. General reaction conditions: Fe(OTf)2 (3–5 mol%), 1a or 1b (0.5 mmol), 2 (0.65–1.0 mmol), TMSN3 (0.7–1.0 mmol), a b TBPB (0.75–1.0 mmol) in DME (2 mL) at rt under an N2 atmosphere. Instead of TBPB, lauroyl peroxides (LPO, 0.75 mmol) was applied. 50 °C effective in this reaction as the direct azidation of alkyl iodides to found that compound 81 could be converted into a 2H-azirine form alkyl azides occurs. It should be noted that the reactions (82) in toluene at 120 °C (Fig. 6b). with perfluoroalkyl iodides are very fast, completing in 10 min in With these conditions identified, we studied the substrate many cases. scope regarding alkyl iodides and alkynes. The results are shown Subsequently, we studied the substrate scope of olefins (Fig. 4 in Fig. 7 and Supplementary Figs. 209–283. Fluoroalkyl iodides and Supplementary Figs. 35–189). As examples, α-azido esters and aryl alkynes react well in these transformations. Reaction of (16–27 in Fig. 4a), β-azido esters (28–37 in Fig. 4b), γ-azido esters 1-iododecane with ethynylbenzene does not deliver the desired (38–63 in Fig. 4c), other azido acid derivatives (64–69 in product. As an example, reaction of 1-octyne delivers only the Fig. 4d–g) and organoazides (70–75 in Fig. 4h) were obtained. ATRA product (107)37 in 42% yield. The functional group compatibility of this reaction is good: a To highlight the synthetic applications of this method further, series of functional groups, such as halogen, ester, carboxylic vinyl azides and 2H-azirine were converted to 10838 10939 and acid (69), and free hydroxyl group (74) are tolerated under the 11040 in high yields (Fig. 8 and Supplementary Figs. 284–295). reaction conditions. Both terminal and internal alkenes (28–37, The geometry of vinyl azides was confirmed by X-ray crystal- 58, and 65) are compatible with the reaction. The carboazidation lographic analysis of product 109 (see details in Supplementary reactions of 1-octene with iodomethane and iodobutane are not Figure 1 and Supplementary Table 3). successful under the reaction conditions. To highlight the synthetic applications, 8, 19 and 78 were reduced to amine 7611, amino acid 7726 and pyrrolidinone 79, Discussion respectively (Fig.
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