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Inflammation and Cancer: the Macrophage Connection
32 MEDICINA - Volumen 67 - NºISSN (Supl. 0025-7680 II), 2007 International Symposium MEDICINA (Buenos Aires) 2007; 67 (Supl. II): 32-34 NEW DIRECTIONS IN CANCER MANAGEMENT Academia Nacional de Medicina Buenos Aires, 6-8 June 2007 INFLAMMATION AND CANCER: THE MACROPHAGE CONNECTION ALBERTO MANTOVANI Istituto Clinico Humanitas, Milán, Italia Abstract Macrophages are key orchestrators of chronic inflammation. They respond to microenvironmental signals with polarized genetic and functional programmes. M1 macrophages which are classically activated by microbial products and interferon-γ, are potent effector cells which kill microorganisms and tumors. In contrast, M2 cells, tune inflammation and adaptive immunity; promote cell proliferation by producing growth factors and products of the arginase pathway (ornithine and polyamines); scavenge debris by expressing scav- enger receptors; promote angiogenesis, tissue remodeling and repair. M1 and M2 cells represent simplified ex- tremes of a continuum of functional states. Available information suggests that TAM are a prototypic M2 popula- tion. M2 polarization of phagocytes sets these cells in a tissue remodelling, and repair mode. And orchestrate the smouldering and polarized chronic inflammation associated to established neoplasia. Recent studies have begun to address the central issue of the relationship between genetic events causing cancer and activation of pro-tumor inflammatory reactions. Rearrangement of the RET oncogene (RET/PTC) is a frequent, causative and sufficient event in papillary carcinoma of the thyroid. It was recently observed that RET/PTC activates a pro- inflammatory genetic programme in primary human thyrocytes, including in particular chemokines and chemokine receptors. These molecules are also expressed in vivo and more so in metastatic tumors. These results high- light a direct connection between an early, causative and sufficient oncogene rearrangement and activation of a pro-inflammatory programme in a human tumor. -
Wandering Pathways in the Regulation of Innate Immunity and Inflammation
WANDERING PATHWAYS IN THE REGULATION OF INNATE IMMUNITY AND INFLAMMATION Alberto Mantovani Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano (Milan), Italy; Humanitas University, via Rita Levi Montalcini, 20090 Pieve Emanuele (Milan), Italy; The William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ. 1 Abstract Tumor-associated macrophages (TAM) have served as a paradigm of cancer-related inflammation. Moreover, investigations on TAM have led to the dissection of macrophage plasticity and polarization and to the discovery and analysis of molecular pathways of innate immunity, in particular cytokines, chemokines and PTX3 as a prototypic fluid phase pattern recognition molecule. Mechanisms of negative regulation are complex and include decoy receptors, receptor antagonists, anti-inflammatory cytokines and the signalling regulator IL-1R8. In this review, topics and open issues in relation to regulation of innate immunity and inflammation and specific issues are discussed: 1) how macrophage and neutrophil plasticity and polarization underlie diverse pathological conditions ranging from autoimmunity to cancer and may pave the way to innovative diagnostic and therapeutic approaches; 2) the key role of decoy receptors and negative regulators (e.g. IL-1R2, ACKR2, IL-1R8) in striking a balance between amplification of immunity and resolution versus uncontrolled inflammation and tissue damage; 3) role of humoral innate immunity, illustrated by PTX3, in resistance against selected microbes, regulation of inflammation and immunity and tissue repair, with implications for diagnostic and therapeutic translation. 2 1. Encounter with the big eaters: the good, the bad and the never ugly macrophage I trained as a physician scientist, spending a substantial part of my time in the lab, first at the Institute of General Pathology (Molecular Biology, in pioneering early days), then at the Mario Negri Institute (immunology, Dr. -
Final Program Auspices
Final program Auspices Under the auspices of: Supported by: 1 Committees SCIENTIFIC COORDINATOR Gabriella Sozzi (IRCCS National Cancer Institute, Milan, Italy) LOCAL SCIENTIFIC AND ORGANIZING COMMITTEE Giovanni Apolone (Scientific Director, IRCCS National Cancer Institute, Milan, Italy) Andrea Anichini (IRCCS National Cancer Institute, Milan, Italy) Mario Colombo (IRCCS National Cancer Institute, Milan, Italy) Filippo De Braud (IRCCS National Cancer Institute, Milan, Italy) Massimo Di Nicola (IRCCS National Cancer Institute, Milan, Italy) Andrea Ferrari (IRCCS National Cancer Institute, Milan, Italy) Marina Garassino (IRCCS National Cancer Institute, Milan, Italy) Marilena Iorio (IRCCS National Cancer Institute, Milan, Italy) Delia Mezzanzanica (IRCCS National Cancer Institute, Milan, Italy) Ugo Pastorino (IRCCS National Cancer Institute, Milan, Italy) Filippo Pietrantonio (IRCCS National Cancer Institute, Milan, Italy) Luca Roz (IRCCS National Cancer Institute, Milan, Italy) Elda Tagliabue (IRCCS National Cancer Institute, Milan, Italy) SIC SCIENTIFIC BOARD President Gabriella Sozzi (IRCCS National Cancer Institute, Milan, Italy) President Elect Nicola Normanno (National Cancer Institute “G. Pascale”, Naples, Italy) Board Paola Chiarugi (University of Florence, Italy) Amedeo Columbano (University of Cagliari, Italy) Rita Falcioni (Regina Elena National Cancer Institute, Rome, Italy) Davide Melisi (University of Verona, Italy) Katia Scotlandi (IRCCS Orthopaedic Rizzoli Institute, Bologna, Italy) Elda Tagliabue (IRCCS National Cancer Institute, -
Neutrophil 2016”
Inflammation, Immunity and Cancer: Neutrophils and Other Leukocytes The Society For Leukocyte Biology’s 49th Annual Meeting and “Neutrophil 2016” September 15-17, 2016 • University of Verona Congress Center • Verona, Italy Program Book www.leukocytebiology.org Inflammation, Immunity and Cancer: Neutrophils and Other Leukocytes The Society For Leukocyte Biology’s 49th Annual Meeting and “Neutrophil 2016” Thank You to Our 2016 Sponsors SILVER SPONSOR SPECIAL THANKS Funding for this conference was made possible [in part] by 1 R13 AI124612-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. BRONZE SPONSORS CONTRIBUTING SPONSOR Welcome letter Dear Colleagues, It is our great pleasure to welcome you to this Joint Meeting of the Society for Leukocyte Biology (SLB) and Neutrophil 2016. In addition to an outstanding scientific program, the meeting is held in beautiful Verona, a city teeming with history from the Roman empire to the Middle Ages and Italian Renaissance (it is after all the home of Romeo and Juliet), to the Napoleonic and Austrian empires. The city and its region has numerous architectural gems of its rich past, and is located near the majestic Garda Lake and the world-renowned Valpolicella wine-producing area, dating back to Roman times. The theme for this year’s meeting is “Inflammation, Immunity and Cancer: Neutrophils and Other Leukocytes.” Our Keynote Speaker, and recipient of the Bonazinga award, is William Nauseef (University of Iowa). -
Printable List of Laureates
Laureates of the Canadian Medical Hall of Fame A E Maude Abbott MD* (1994) Connie J. Eaves PhD (2019) Albert Aguayo MD(2011) John Evans MD* (2000) Oswald Avery MD (2004) F B Ray Farquharson MD* (1998) Elizabeth Bagshaw MD* (2007) Hon. Sylvia Fedoruk MA* (2009) Sir Frederick Banting MD* (1994) William Feindel MD PhD* (2003) Henry Barnett MD* (1995) B. Brett Finlay PhD (2018) Murray Barr MD* (1998) C. Miller Fisher MD* (1998) Charles Beer PhD* (1997) James FitzGerald MD PhD* (2004) Bernard Belleau PhD* (2000) Claude Fortier MD* (1998) Philip B. Berger MD (2018) Terry Fox* (2012) Michel G. Bergeron MD (2017) Armand Frappier MD* (2012) Alan Bernstein PhD (2015) Clarke Fraser MD PhD* (2012) Charles H. Best MD PhD* (1994) Henry Friesen MD (2001) Norman Bethune MD* (1998) John Bienenstock MD (2011) G Wilfred G. Bigelow MD* (1997) William Gallie MD* (2001) Michael Bliss PhD* (2016) Jacques Genest MD* (1994) Roberta Bondar MD PhD (1998) Gustave Gingras MD* (1998) John Bradley MD* (2001) Phil Gold MD PhD (2010) Henri Breault MD* (1997) Richard G. Goldbloom MD (2017) G. Malcolm Brown PhD* (2000) Jean Gray MD (2020) John Symonds Lyon Browne MD PhD* (1994) Wilfred Grenfell MD* (1997) Alan Burton PhD* (2010) Gordon Guyatt MD (2016) C H G. Brock Chisholm MD (2019) Vladimir Hachinski MD (2018) Harvey Max Chochnov, MD PhD (2020) Antoine Hakim MD PhD (2013) Bruce Chown MD* (1995) Justice Emmett Hall* (2017) Michel Chrétien MD (2017) Judith G. Hall MD (2015) William A. Cochrane MD* (2010) Michael R. Hayden MD PhD (2017) May Cohen MD (2016) Donald O. -
Lauréats 2003
LES LAURÉATS 2003 LES LAURÉATS 2003 MICHEL 8 VAN SCHENDEL LOUIS 12 TAILLEFER ANDRÉE 16 LAJOIE RAYMONDE 20 APRIL ROBERT 24 LEPAGE ANDRÉ 28 FORCIER MARCEL 32 JUNIUS CHARLES E. 36 BEAULIEU FREDERICK 40 ANDERMANN ANDRÉ 44 GAULIN LORNE 48 TROTTIER LES LAURÉATS 2003 Cette brochure a été réalisée conjointement par le ministère de la Culture et des Communications et le ministère du Développement économique et régional Recherche et rédaction Janette Biondi pour les prix Denise-Pelletier, Paul-Émile-Borduas et Albert-Tessier Gaëtan Lemay pour les prix Georges-Émile-Lapalme et Athanase-David Valérie Borde pour les prix Léon-Gérin, Marie-Victorin, Wilder-Penfield, Armand-Frappier et Lionel-Boulet Révision linguistique France Galarneau Hélène Dumais Photographie Marc-André Grenier Conception et réalisation Barrette Communication Graphique Pré-impression et impression Litho Chic ISBN 2-550-41676-7 Dépôt légal : 2003 Bibliothèque nationale du Québec Bibliothèque nationale du Canada © Gouvernement du Québec, 2003 Site Internet des Prix du Québec http://www.prixduquebec.gouv.qc.ca MOT DES MINISTRES 2003 Le Québec, société moderne et ouverte, se bâtit grâce à des visionnaires, à des hommes et des femmes dont les réalisations remarquables con- tribuent à son essor économique, social et culturel. Les lauréates et les lauréats des Prix du Québec 2003 font partie de ces êtres d’exception qui ont su façonner le monde de la science et celui de la culture et repousser plus loin encore les limites de la connaissance et de la performance. Avec les Prix du Québec, le gouvernement honore des gens de passion, des gens animés par le désir de créer et d’innover, qui laisseront un héritage important dans leur domaine d’excellence. -
Les Prix Du Québec En Consultant Le Site Internet Suivant : • La Présente Brochure Est Disponible En Format PDF Sur Ce Site
MISE EN CANDIDATURE 2005 DOMAINE SCIENTIFIQUE TABLE DES MATIÈRES 3 Mot du ministre 4 Historique des Prix du Québec 5 Description des prix scientifiques 6 Conditions d’admissibilité 6 Dossier de candidature 7 Composition des jurys Calendrier 8 Critères d’évaluation Présentation des demandes Scientifiques qui ont donné leur nom aux prix 9 Léon Gérin (1863-1951) 10 Frère Marie-Victorin (1886-1944) 11 Wilder Penfield (1891-1976) 12 Armand Frappier (1904-1991) 13 Lionel Boulet (1919-1996) 14 Lauréats des années antérieures • Vous pouvez obtenir des renseignements additionnels sur les Prix du Québec en consultant le site Internet suivant : www.prixduquebec.gouv.qc.ca • La présente brochure est disponible en format PDF sur ce site. • Vous pouvez également commander d’autres exemplaires en composant le numéro suivant : (418) 646-0980. DOMAINE SCIENTIFIQUE 2 MOT DU MINISTRE C’est avec grand plaisir que je sollicite votre collaboration pour la campagne de mise en candidature des Prix du Québec, édition 2005. Je vous invite à proposer le nom de candidates et de candidats qui contribuent, à votre avis, au développement scientifique de la société québécoise de même qu’à son rayonnement sur la scène internationale. Synonymes d’excellence, de persévérance et de dépassement, ces personnes émérites incitent des jeunes de plus en plus nombreux à entreprendre des carrières passionnantes et importantes dans le monde des sciences. C'est depuis 1977 que le Québec salue des femmes et des hommes d’exception en leur décernant les Prix du Québec, la plus importante récompense honorifique attribuée par le gouvernement québécois. Ces prix sont non seulement un témoignage de reconnaissance, mais ils expriment aussi la fierté et l’admiration de la population d’ici pour ces êtres remarquables. -
IL-1 Signaling Member Serving As A
Discovery of the DIGIRR Gene from Teleost Fish: A Novel Toll−IL-1 Receptor Family Member Serving as a Negative Regulator of IL-1 Signaling This information is current as of October 1, 2021. Yi-feng Gu, Yu Fang, Yang Jin, Wei-ren Dong, Li-xin Xiang and Jian-zhong Shao J Immunol 2011; 187:2514-2530; Prepublished online 29 July 2011; doi: 10.4049/jimmunol.1003457 Downloaded from http://www.jimmunol.org/content/187/5/2514 Supplementary http://www.jimmunol.org/content/suppl/2011/07/29/jimmunol.100345 Material 7.DC1 http://www.jimmunol.org/ References This article cites 87 articles, 26 of which you can access for free at: http://www.jimmunol.org/content/187/5/2514.full#ref-list-1 Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision by guest on October 1, 2021 • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2011 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology Discovery of the DIGIRR Gene from Teleost Fish: A Novel Toll–IL-1 Receptor Family Member Serving as a Negative Regulator of IL-1 Signaling Yi-feng Gu, Yu Fang, Yang Jin, Wei-ren Dong, Li-xin Xiang, and Jian-zhong Shao Toll–IL-1R (TIR) family members play crucial roles in a variety of defense, inflammatory, injury, and stress responses. -
CORRESPONDENCE Colour*Biind Drivers of Motor Vehicles, J.D.H
CORRESPONDENCE Colour*biind drivers of motor vehicles, J.D.H. lies 1566 Screening for ovarian cancer, B. Dixon-Warren; D.R. Popkin 1566 A foundling hospital anthem for the International Year of the Child, A.J. Macnab, 1567 H.i. Macnab Use of choline In the treatment of ataxia associated with multiple sclerosis, R.A. Blattel 1568 Planning for psychiatric emergencies, A.J.R. Finlayson; M.R. Eastwood, S. Stiasny, 1568 F. Cashman, S.K. Littmann, G. Voineskos Skateboard injuries, V. Marchessault 1570 Nephrolithiasis in rural practice, R.J. Woistenholme 1570 Clinical pharmacology and therapeutics of benzodiazepines, D.P. Zarowny 1571 The Canada Health Survey - who will pay for it? W.A. McLeish 1571 Tuberculous cervical lymphadenitis, RN. Rivington 1572 Vietnamese refugees, M.L. Schwartz; A. Chan 1572 Psychiatric illness in physicians, G.A. Bailey 1572 Books 1579 Book Reviews 1597 Therapeutic Section and index 1600 Personal File 1624 Classified AdvertisIng 1626 Advertisers' Index 1634 CMA JOURNAL/DECEMBER 22, 1979/VOL. 121 1559 ing the role of neuraminidase in the 5. DowNn JC, LAyER WG: Isolation of the 2nd international Congress control of influenza. We think that of a type A influenza virus from an for Virology, MELNICK JL (ed), Australian pelagic bird. Virology 51: Karger, Basel, 1972, p 121 a vaccine containing only pure 259, 1973 23. COUCH RB, KASEL JA, GERIN JL, neuraminidase may prove to be 6. SCHULMAN JL: Immunology of in- et al: Induction of partial immunity ideal. On the basis of Kilbourne fluenza, in influenza Viruses and to influenza by a neuraminidase- and colleagues' hypothesis, natural influenza, KILBOURNE ED (ed), specific vaccine. -
Il-1 and Il-1 Regulatory Pathways in Cancer Progression And
1 Immunol Rev. – IL-1 AND IL-1 REGULATORY PATHWAYS IN CANCER PROGRESSION AND THERAPY Alberto Mantovani1,2,3,*, Isabella Barajon2 and Cecilia Garlanda1,2 1Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano (Milan), Italy; 2Humanitas University, via Rita Levi Montalcini 4, 20090 Pieve Emanuele (Milan), Italy; 3The William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ. *Correspondence: Alberto Mantovani Tel 0039 02 82242445 FAX 0039 02 82245101 [email protected] 2 Running title: IL-1 in cancer Abstract Inflammation is an important component of the tumor microenvironment. IL-1 is an inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL-1 is subject to regulation by components of the IL-1 and IL-1 receptor (ILR) families. Negative regulators include a decoy receptor (IL-1R2), receptor antagonists (IL-1Ra), IL-1R8, and anti-inflammatory IL-37. IL- 1 acts at different levels in tumor initiation and progression, including driving chronic non-resolving inflammation, tumor angiogenesis, activation of the IL-17 pathway, induction of myeloid-derived suppressor cells (MDSC) and macrophage recruitment, invasion and metastasis. Based on initial clinical results, the translation potential of IL-1 targeting deserves extensive analysis. Key words: interleukin-1, inflammation, inflammation-associated cancer, therapy 3 Introduction Selected chronic inflammatory conditions increase the risk of developing cancer (the extrinsic pathway) (1). These include infection, autoimmunity and autoinflammation. Colitis- associated cancer has served as a typical example of this connection. In the intrinsic pathway, genetic events, which drive carcinogenesis, orchestrate the construction of an inflammatory microenvironment by direct induction of inflammatory genes or through activation of downstream transcription factors (nuclear factor-κB (NF-κB), signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1α (HIF-1α)). -
A Model for Their Trafficking Chemokine Receptors During Dendritic
c Cutting Edge: Differential Regulation of Chemokine Receptors During Dendritic Cell Maturation: A Model for Their Trafficking Properties1 Silvano Sozzani,2,3* Paola Allavena,2* Giovanna D’Amico,* Walter Luini,* Giancarlo Bianchi,* Motoji Kataura,† Toshio Imai,† Osamu Yoshie,† Raffaella Bonecchi,* and Alberto Mantovani*‡ known that DC trafficking is regulated. Bone marrow and blood Upon exposure to immune or inflammatory stimuli, dendritic DC progenitors seed nonlymphoid tissues, where they develop into cells (DC) migrate from peripheral tissues to lymphoid organs, immature DC with high ability to capture Ags. Immune and in- where they present Ag. CC chemokines induce chemotactic and flammatory signals induce mobilization of DC from the periphery transendothelial migration of immature DC, in vitro. Maturation to lymph nodes or spleen T cell areas and a shift from a “process- of DC by CD40L, or by LPS, IL-1, and TNF, induces down-reg- ing” to a “presenting” stage, characterized by an increased capacity ulation of the two main CC chemokine receptors expressed by to stimulate T lymphocytes (5–11). these cells, CCR1 and CCR5, and abrogates chemotaxis to their The current concept of the multistep process of leukocyte recruit- ligands. Inhibition was rapid (<1 h) and included the unrelated ment into tissues envisions chemotactic agonists as one of the key agent FMLP. Concomitantly, the expression of CCR7 and the effector molecules (12–14). Chemokines are a superfamily of chemo- migration to its ligand EBI1 ligand chemokine (ELC)/macro- tactic proteins that can be divided in four groups on the basis of a phage inflammatory protein (MIP)-3b, a chemokine expressed in cysteine structural motif. -
Ovarian Carcinoma Macrophages Associated with Human
Defective Expression of the Monocyte Chemotactic Protein-1 Receptor CCR2 in Macrophages Associated with Human Ovarian Carcinoma This information is current as of September 24, 2021. Antonio Sica, Alessandra Saccani, Barbara Bottazzi, Sergio Bernasconi, Paola Allavena, Brancatelli Gaetano, Francesca Fei, Graig LaRosa, Chris Scotton, Frances Balkwill and Alberto Mantovani J Immunol 2000; 164:733-738; ; Downloaded from doi: 10.4049/jimmunol.164.2.733 http://www.jimmunol.org/content/164/2/733 http://www.jimmunol.org/ References This article cites 53 articles, 20 of which you can access for free at: http://www.jimmunol.org/content/164/2/733.full#ref-list-1 Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists by guest on September 24, 2021 • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2000 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Defective Expression of the Monocyte Chemotactic Protein-1 Receptor CCR2 in Macrophages Associated with Human Ovarian Carcinoma1 Antonio Sica,2* Alessandra Saccani,* Barbara Bottazzi,* Sergio Bernasconi,* Paola Allavena,* Brancatelli Gaetano,† Francesca Fei,† Graig LaRosa,‡ Chris Scotton,§ Frances Balkwill,§ and Alberto Mantovani*¶ Monocyte chemotactic protein-1 (MCP-1, CCL2) is an important determinant of macrophage infiltration in tumors, ovarian carcinoma in particular.