Rest in Peace, Angalifu

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Rest in Peace, Angalifu 14 ZOONOOZ n FEBRUARY 2015 Angalifu was one of a handful of northern white rhinos left in the world. He passed away at the Safari Park of natural causes. By Karyl Carmignani STAFF WRITER Photos by Ken Bohn SDZG PHOTOGRAPHER hen the elderly northern white rhinoceros Angalifu Zoo Global remains committed to fnding a solution to this gloomy Wpassed away on December 14, 2014, he lef a gigantic hole in many conservation story. Biological samples have been preserved in our hearts. “Angalifu’s death is a tremendous loss to all of us,” said Ran- Frozen Zoo®, with the hope that new reproductive technologies will dy Rieches, curator of mammals for the San Diego Zoo Safari Park, allow recovery of the northern white rhino. “not only because he was so well loved here at the Safari Park but In honor of Angalifu and all our rhinos at the Zoo and Safari also because his death brings this wonderful subspecies one step Park, as well as their wild counterparts, the May issue of ZOO- closer to extinction.” Estimated to be about 44 years old, Angalifu NOOZ will be a special issue focusing on rhinoceroses. Look for ar- was being treated for a variety of age-related conditions and died ticles about the diferent types of rhinos, the relentless threats they of natural causes. Like the remaining fve northern white rhinos face in their native countries, the conservation work that is taking lef in the world (one female at the Safari Park, one at a zoo in the place to try to save them, and San Diego Zoo Global’s role, past and Czech Republic, and three at a sanctuary in Kenya), all are in their present, in caring for and supporting these noble animals. n post-reproductive “golden years.” Despite the dire odds, San Diego SAN DIEGO ZOO GLOBAL n SANDIEGOZOO.ORG 15.

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Zoo Launches Genetic Project to Save Northern White Rhino POSTED by DEBBIE L
ABOUT STAFF CONTACT ADVERTISE FAQ PRIVACY POLICY TERMS OF SERVICE ALL POLITICS CRIME BUSINESS SPORTS EDUCATION ARTS MILITARY TECH LIFE OSPeIaNrcIOh…N LATEST NEWS Homeland Security Funded, But Hunter, Issa Vote 'No' Home » Tech » This Article Zoo Launches Genetic Project to Save Northern White Rhino POSTED BY DEBBIE L. SKLAR ON FEBRUARY 26, 2015 IN TECH | 346 VIEWS | LEAVE A RESPONSE Recommend Share 199 GET TIMES OF SAN DIEGO BY EMAIL Our free newsletter is delivered at 8 a.m. daily. Email Address Nola, a Northern White rhino at the Safari Park at the San Diego Zoo. Photo via The San Diego Zoo SUBSCRIBE With support from the Seaver Institute, geneticists at San Diego Zoo Institute for Conservation Research are taking the initial steps in an effort to use cryopreserved cells to bring back the northern white rhino from the brink of extinction. Living cells banked in the San Diego Zoo’s Frozen Zoo have preserved the genetic lineage of 12 northern white rhinos, including a male that recently passed away at the Safari Park. Scientists hope that new technologies can be used to gather the genetic knowledge needed to create a viable population for this disappearing subspecies, of which only five are left. “Multiple steps must be accomplished to reach the goal of establishing a viable population that can be reintroduced into the species range in Africa, where it is now extinct,” said Oliver Ryder Ph.D., director of genetics for the San Diego Zoo Institute for Conservation Research. “A first step involves sequencing the genomes of northern white rhinos to clarify the extent of genetic divergence from their closest relative, the southern white rhino.” The next step would require conversion of the cells preserved in the Frozen Zoo to stem cells that could develop into sperm and eggs.
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Downloaded from genome.cshlp.org on September 26, 2021 - Published by Cold Spring Harbor Laboratory Press Research Evaluating recovery potential of the northern white rhinoceros from cryopreserved somatic cells Tate Tunstall,1 Richard Kock,2 Jiri Vahala,3 Mark Diekhans,4 Ian Fiddes,4 Joel Armstrong,4 Benedict Paten,4 Oliver A. Ryder,1,5 and Cynthia C. Steiner1,5 1San Diego Zoo Institute for Conservation Research, Escondido, California 92027, USA; 2Royal Veterinary College, University of London, London NW1 0TU, United Kingdom; 3Dvur Krlov Zoo, Dvr Krlov nad Labem 544 01, Czech Republic; 4Jack Baskin School of Engineering, University California Santa Cruz, Santa Cruz, California 95064, USA The critically endangered northern white rhinoceros is believed to be extinct in the wild, with the recent death of the last male leaving only two remaining individuals in captivity. Its extinction would appear inevitable, but the development of advanced cell and reproductive technologies such as cloning by nuclear transfer and the artificial production of gametes via stem cells differentiation offer a second chance for its survival. In this work, we analyzed genome-wide levels of genetic diversity, inbreeding, population history, and demography of the white rhinoceros sequenced from cryopreserved somatic cells, with the goal of informing how genetically valuable individuals could be used in future efforts toward the genetic res- cue of the northern white rhinoceros. We present the first sequenced genomes of the northern white rhinoceros, which show relatively high levels of heterozygosity and an average genetic divergence of 0.1% compared with the southern sub- species. The two white rhinoceros subspecies appear to be closely related, with low genetic admixture and a divergent time <80,000 yr ago.
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Contents 1 Northern White Rhinoceros Pedigree
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