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Safety Assessment of Alkyl Betaines As Used in Cosmetics
Safety Assessment of Alkyl Betaines as Used in Cosmetics Status: Draft Tentative Report for Panel Review Release Date: November 15, 2013 Panel Meeting Date: December 9-10, 2013 The 2013 Cosmetic Ingredient Review Expert Panel members are: Chairman, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; Ronald A. Hill, Ph.D. James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Director is Lillian J. Gill, DPA. This safety assessment was prepared by Christina L. Burnett, Scientific Analyst/Writer, and Bart Heldreth, Ph.D., Chemist CIR. © Cosmetic Ingredient Review 1101 17th Street, NW, Suite 412 Washington, DC 20036-4702 ph 202.331.0651 fax 202.331.0088 [email protected] Distributed for Comment Only -- Do Not Cite or Quote Commitment & Credibility since 1976 Memorandum To: CIR Expert Panel Members and Liaisons From: Christina L. Burnett Scientific Writer/Analyst Date: November 15, 2013 Subject: Draft Tentative Report on Alkyl Betaines At the September 2013 CIR Expert Panel Meeting, the Panel issued an insufficient data announcement on the safety assessment of alkyl betaine ingredients. The data needs included: (1) method of manufacturing; and (2) impurities. Since the announcement, we have received method of manufacturing and impurities data from a supplier of coco- betaine. This data along with basic composition data on a betaine analog from the European Chemicals Agency (ECHA) database and basic method of manufacturing data on food-grade betaine have been incorporated in the report. -
Cocamidopropyl Betaine
COCAMIDOPROPYL BETAINE Your patch test result indicates that you have a contact allergy to cocamidopropyl betaine. This contact allergy may cause your skin to react when it is exposed to this substance although it may take several days for the symptoms to appear. Typical symptoms include redness, swelling, itching and fluid-filled blisters. Where is cocamidopropyl betaine found? Cocamidopropyl betaine is used in personal care products like shampoos, hand soaps, and toothpastes, and in cosmetics as an emulsifying agent and thickener. It is also used in conditioners to reduce static cling. How can you avoid contact with cocamidopropyl betaine? Avoid products that list any of the following names in the ingredients: • 1-Propanaminium, N-(carboxymethyl)- N,N-dimethyl-3-((1-oxococonut)amino)-, hydroxide, inner salt • N-(2-Aminoethyl)-N-(2-(2- carboxyethoxy)ethyl) beta-alanine, norcoco acyl derivs., disodium salts • N-(Carboxymethyl)-N,N-dimethyl-3-((1- oxococonut)amino)-1-propanam- inium • Cocamidopropyl betaine • Cocamidopropyl dimethyl glycine • CAS RN: 61789-40-0 What are some products that may contain cocamidopropyl betaine? Anti-fungal: Shampoo/Conditioner: • Mycocide NS • Alberto VO5 Extra Body Shampoo • Alberto VO5 Herbal Escapes Moisturizing Shampoo Cosmetics: • Alberto VO5 Moisture Milks Nourishing Shampoo • Gillette Multi-Glide Shave Gel B,CPB • Alberto VO5 Normal Shampoo Hair Coloring Kits: • Aveeno Baby Wash & Shampoo • Clairol Natural Instincts Haircolor, Level 2, Hazelnut-20 • Charles Worthington Big Hair Full Volume Shampoo • -
Enhancing the Efficacy of Antimicrobial Peptide BM2, Against Mono-Species Biofilms, with Detergents
Enhancing the efficacy of Antimicrobial peptide BM2, against mono-species biofilms, by combining with detergents A thesis submitted for the degree of Doctor of Clinical Dentistry (Endodontics) Arpana Arthi Devi Department of Oral Rehabilitation, School of Dentistry, University of Otago, Dunedin, New Zealand 2016 Abstract Title Enhancing the efficacy of antimicrobial peptide BM2, against mono-species biofilms, by combining with detergents. Aim To investigate if a detergent regime could enhance the antimicrobial ability of BM2. Method Strains of Enterococcus faecalis, Streptococcus gordonii, Streptococcus mutans, and Candida albicans were grown from glycerol stocks after confirmation of the strains. After subculturing single colonies were cultured in TSB and CSM liquid media for 24hr to obtain a microbial suspension which was adjusted to OD600nm = 0.5. Dilution series of the peptidomimetic BM2 and detergents were prepared in aqueous solution and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined using a broth micro-dilution method. Further on planktonic cells and monospecies biofilms were exposed to the detergent and BM2 combinations. The efficacy of BM2 and detergents at causing biofilm detachment was measured using a crystal violet based assay. Results Planktonic cells were easier to kill with some of the detergents in isolation or in combination with BM2. SDS and CTAB in combination with BM2 increased the efficacy of BM2 against the test organisms. Tween 20 did not kill any of the test organisms alone or in combination. Biofilms were harder to eradicate and detergent, BM2 combinations gave varied results for the different species tested. Detergents in combination with BM2 did not increase the efficacy of the antimicrobial peptide in disrupting S. -
Ethoxylation Reactor Modelling and Design
Ethoxylation Reactor Modelling and Design by Yen-ni Chiu Bachelor of Engineering (Chemical) UNSW A thesis submitted in fulfillment of the requirements for the degree of Doctor of Philosophy Facaulty of Engineering and Industrial Sciences Swinburne University of Technology Melbourne, Australia To Mum, Dad, Jess and Ted Abstract The manufacture of nonionic surfactants generally involves ethoxylation via ethylene oxide condensation onto a hydrophobe substrate, mostly in the presence of an alkaline catalyst. Nonionic surfactants are used widely in industrial applications, such as detergents, health and personal care, coatings, and polymers. In Australia, approximately one-third of the annual consumption of nonionic surfactants is imported from offshore manufacturers; the market is highly competitive with the local manufacturer facing increasing competition from imports. Optimisation is a pressing need for the current manufacturing plant of the industrial partner for this research project, Huntsman Corporation Australia Pty Limited, the sole domestic manufacturer of nonionic surfactants in Australia. Therefore, the objectives of this research project were • to gain a better understanding of the various chemical and physical processes occurring simultaneously in an ethoxylation process; • to identify the process limitation in an existing production plant operated by Huntsman Corporation Australia, and • to explore measures for enhancing the asset productivity of the production plant. An ethoxylation process working model, describing the chemical kinetics and the physical transport processes involved, was developed to aid the exploration of optimisation opportunities, which would otherwise be empirical. Accordingly, this research project was structured into a two-stage program. The first stage determined the ethoxylation kinetics experimentally. The second stage investigated the interactions of physical transport processes numerically using a computational fluid dynamics (CFD) technique. -
United States Patent (19) 11 Patent Number: 6,013,801 Köll, Deceased Et Al
US00601 3801A United States Patent (19) 11 Patent Number: 6,013,801 Köll, deceased et al. (45) Date of Patent: Jan. 11, 2000 54 METHOD FOR PRODUCING 4,590,223 5/1986 Arai et al. ........................... 544/401 X AMINOETHYLETHANOLAMINE AND/OR 5,455,352 10/1995 Huellmann et al. .................... 544/401 HYDROXYETHYL PPERAZINE FOREIGN PATENT DOCUMENTS 75 Inventors: Juhan Köll, deceased, late of Stenungsund, by Mall Koll, legal 0 354993 2/1990 European Pat. Off. ...... CO7C 213/06 representative; Magnus Frank, 2013 676 1/1972 Germany ....................... CO7D 51/64 Göteborg, both of Sweden 27 16946 10/1978 Germany ....................... CO7C 89/02 206670 2/1984 Germany. 73 Assignee: Akzo Nobel N.V., Arnhem, Netherlands 1512967 10/1989 Russian Federation ........ CO7C 91/12 21 Appl. No.: 08/875,871 OTHER PUBLICATIONS 22 PCT Filed: Jan. 11, 1996 86 PCT No.: PCT/EP96/00207 Ludwig Knorr und Henry W. Brownadon: Ueber Alkohol basen aus Aethylendiamin und uber das Aethylenbismor S371 Date: Oct. 30, 1998 pholin, Dec. 11, 1902 pp. 4470–4473. S 102(e) Date: Oct. 30, 1998 87 PCT Pub. No.: WO96/24576 Primary Examiner Michael G. Ambrose PCT Pub. Date: Aug. 15, 1996 Attorney, Agent, or Firm-Ralph J. Mancini 30 Foreign Application Priority Data 57 ABSTRACT Feb. 8, 1995 (SE) Sweden .................................. 9500444 A method for preparing aminoethylethanolamine, and/or hydroxyethylpiperazine is described. Reaction of ethylene 51) Int. Cl." ........................ C07D 295/88; CO7C 213/04 oxide with ethylendiamine, piperazine, or a mixture of both 52 U.S. Cl. ............................................. 544/401; 564/503 produces these compounds. The process is integrated into a 58 Field of Search ............................. -
(Dimethylamino)Propylamine
3-Dimethylaminopropylamine 109-55-7 OVERVIEW This material was prepared for the National Cancer Institute (NCI) for consideration by the Chemical Selection Working Group (CSWG) by Technical Resources International, Inc. under Contract no. N02-07007. 3-Dimethylaminopropylamine (DMAPA) came to the attention of the National Cancer Institute (NCI) Division of Cancer Biology as the result of a review of chemical industry information suggesting an increased production or use of this chemical. DMAPA appears to have a significant and increasing demand for its use in personal care products. This chemical also has applications in the leather processing, paper, and rubber industries and is an intermediate in the production of fabric softeners, polymers, agrochemicals, flocculating agents, liquid soaps, and dye intermediates. There is a lack of information on the chronic toxicity of DMAPA and other chemicals structurally related to DMAPA. In a SIDS screen, DMAPA produced deaths in high dose animals exposed for 28 days, but this chemical lacked reproductive or developmental effects and produced a negative mutagenicity profile. Workers occupationally exposed to DMAPA at concentrations of 0.55-1.38 mg/m3 experienced impaired respiration that may not have been completely reversible even when concentrations of DMAPA were reduced. Given the lack of chronic toxicity data for DMAPA, its high production volume, and its widespread use, additional toxicity testing appears warranted. NOMINATION OF 3-DIMETHYLAMINOPROPYLAMINE TO THE NTP Based on a review of available -
Fatty Acids: Fatty Acid Is a Carboxylic Acid Often with a Long Aliphatic Chain, Which Is Either Saturated Or Unsaturated
Introduction 1 Fatty Acids: Fatty acid is a carboxylic acid often with a long aliphatic chain, which is either saturated or unsaturated. Fatty acids and their derivatives are consumed in a wide variety because they are used as raw materials for a wide variety of industrial products like, paints, surfactant, textiles, plastics, rubber, cosmetics, foods and pharmaceuticals. Industrially, fatty acids are produced by the hydrolysis of triglycerides, with the removal of glycerol moiety. As mentioned before, fatty acids can be classified into two classes, the first is unsaturated fatty acid with one or more double bonds in the alkyl chain and the other is saturated fatty acid. Long chain 3-alkenoic acids are a family of polyunsaturated fatty acids which have in common a carbon–carbon double bond in the position 3. They are used as key precursors for synthesis of many organic compounds. There are many methods for the synthesis of such acids; here we will mention two of these methods. Nucleophilic substitution of allylic substrates with organometallic reagents, treatment of β-vinyl-β-propiolactone with butylmagnesium bromide in the presence of copper(I) iodide in THF at –30 o C, gave 3-nonenoic acid as a major product and 3-butyl-4-pentenoic acid with the ratio 98:2 respectively(1). Knoevenagel condensation of an aldehyde with malonic acid in the presence of organic bases was considerable value for the synthesis of unsaturated fatty acids. This reaction is mainly related to its application for the synthesis of α-β-unsaturated fatty acids. For the synthesis of β-γ-unsaturated fatty acids the Linstead modification (2) of the Knoevenagel condensation, in which triethanolamine or other tertiary amines are used. -
Predicting Distribution of Ethoxylation Homologues With
1 PREDICTING THE DISTRIBUTION OF ETHOXYLATION HOMOLOGUES WITH A PROCESS SIMULATOR Nathan Massey, Chemstations, Inc. Introduction Ethoxylates are generally obtained by additions of ethylene oxide (EO) to compounds containing dissociated protons. Substrates used for ethoxylation are primarily linear and branched C12-C18 alcohols, alkyl phenols, nonyl (propylene trimer) or decyl (propylene tetramer) groups, fatty acids and fatty acid derivatives. The addition of EO to a substrate containing acidic hydrogen is catalyzed by bases or Lewis acids. Amphoteric catalysts, as well as heterogeneous catalysts are also used. The degree of ethoxylation ( the moles of EO added per mole of substrate ) varies over wide ranges, in general between 3 and 40, and is chosen according to the intended use. As an illustration of how this distribution might be predicted using a process simulator, Chemcad was used to simulate the ethoxylation of Nonylphenols. Description of the Ethoxylation Chemistry The reaction mechanisms of base catalyzed and acid catalyzed ethoxylation differ, which affects the composition of the reaction products. In base catalyzed ethoxylation an alcoholate anion, formed initially by reaction with the catalyst ( alkali metal, alkali metal oxide, carbonate, hydroxide, or alkoxide ) nucleophilically attacks EO. The resulting union of the EO addition product can undergo an equilibrium reaction with the alcohol starting material or ethoxylated product, or can react further with EO: Figure 1 O RO- + H2CCH2 - - RO CH2CH2O O ROH H2CCH2 - - RO RO CH2CH2OH RO RO CH2CH2O 2 As Figure 1 illustrates, in alkaline catalyzed ethoxylations several reactions proceed in parallel. The addition of EO to an anion with the formation of an ether bond is irreversible. -
How Safe Are Children's Shampoos?
Available online at www.medicinescience.org Medicine Science ORIGINAL ARTICLE International Medical Journal Medicine Science 2021;10(2):334-7 How safe are children's shampoos? Habip Almis1, Ibrahim Hakan Bucak2, Huseyin Tanriverdi2 1Adiyaman University, School of Medicine, Department of Pediatrics, Division of Social Pediatrics, Adiyaman, Turkey 2Adiyaman University, School of Medicine, Department of Pediatrics, Adiyaman, Turkey Received 30 October 2020; Accepted 19 January 2020 Available online 19.03.2021 with doi: 10.5455/medscience.2020.10.231 Copyright@Author(s) - Available online at www.medicinescience.org Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Abstract Shampoos are daily care products designed to clean the hair and scalp. The aim of this study was to compare the contents of baby and newborn shampoos sold in supermar- kets and pharmacies, determine the levels of substances reported to be dangerous to babies and newborns’ health in these shampoos. This cross-sectional study included 18 newborn and baby shampoos that families could buy at supermarkets and pharmacies in Turkey. For newborn and baby shampoos, the number of preservative substances have been determined. A total of 68 chemicals was found in these 18 shampoos, with an average of 14.83 ± 2.43 chemicals in each shampoo. Most of these chemicals were not recommended for use in children. Shampoos that contain numerous chemicals and substances confirmed to be harmful or have suspicious effects should not be recommended. It is clear that more studies are needed in this under-researched area. Keywords: Child, chemical, newborn, pediatrician, shampoo Introduction Even low levels of chemicals can have negative effects on growth, and these effects are more pronounced during the early stages Hair and body cleaning and care are important routine parts of of life, especially the fetal and infancy periods [3,4]. -
Combined UV-Vis-Absorbance and Reflectance Spectroscopy Study of Dye Transfer Kinetics in Aqueous Mixtures of Surfactants
Noname manuscript No. (will be inserted by the editor) Combined UV-Vis-absorbance and Reflectance Spectroscopy Study of Dye Transfer Kinetics in Aqueous Mixtures of Surfactants Carlos G. Lopez · Anna Manova · Corinna Hoppe · Michael Dreja · Peter Schmiedel · Mareile Job · Walter Richtering · Alexander B¨oker · Larisa Tsarkova Received: date / Accepted: date Abstract We report an analytical approach to study the kinetics of desorp- tion and exhaustion of a hydrophobic dye in a multicomponent washing-model environment. The process of dye transfer between an acceptor textile (white polyamide), detergent micelles and a donor textile (red polyester) was quan- tified by a combination of colorimetric analyses. UV-Vis absorbance and UV- reflectance spectroscopy were used to follow the concentration of the solubilised dye in the micelles and the amount of dyer transferred to the acceptor textile, respectively, as a function of time. Up to ' 10 min of the washing process, the released dye is predominantly solubilised in surfactant micelles. At later times, the adsorption of the dye on the hydrophobic surface of the acceptor textile is energetically favoured. The shift of the desorption equilibrium in the presence of the acceptor textile results in ' 30% increase in the release of the dye. The reported methodology provides insight into the competition between solubili- sation of hydrophobic molecules by amphiphiles and dye adsorption on solid substrates, important for designing novel concepts of dye transfer inhibition. Carlos G. Lopez · Anna Manova · Corinna Hoppe · Walter Richtering Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52056 Aachen, Germany Anna Manova DWI-Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52056 Aachen. -
Locating and Estimating Sources of Ethylene Oxide
United States Office of Air Quality EPA-450/4-84-007L Environmental Protection Planning And Standards Agency Research Triangle Park, NC 27711 September 1986 AIR EPA LOCATING AND ESTIMATING AIR EMISSIONS FROM SOURCES OF ETHYLENE OXIDE L &E EPA- 450/4-84-007L September 1986 LOCATING AND ESTIMATING AIR EMISSIONS FROM SOURCES OF ETHYLENE OXIDE U.S. Environmental Protection Agency Office of Air and Radiation Office of Air Quality Planning and Standards Research Triangle Park, North Carolina 27711 This report has been reviewed by the Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, and approved for publication as received from the contractor. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, neither does mention of trade names or commercial products constitute endorsement or recommendation for use. EPA - 450/4-84-007L TABLE OF CONTENTS Section Page 1 Purpose of Document .......................................... 1 2 Overview of Document Contents ................................ 3 3 Background ................................................... 5 Nature of Pollutant .................................... 5 Overview of Production and Use ......................... 7 References for Section 3 .............................. 14 4 Emissions from Ethylene Oxide Production .................... 16 Ethylene Oxide Production ................................... 16 References for Section 4 .................................... 33 5 Emissions from Industries Which Use Ethylene -
Cocamidopropyl Betaine (CAPB)
Final Report to DWI September 2020 Personal Care Products and Domestic Cleaning Products – Toxicological Assessment of Prioritised List of Chemicals (Ref: DWI 70/2/331) FINAL REPORT Report to Defra/DWI IEH Consulting Ltd.|September 2020 Final Report to DWI September 2020 PCPs and DCPs – toxicological assessment of prioritised list of chemicals A Report to DWI by IEH Consulting Ltd. Disclaimer The views expressed in this report are those of the authors alone, representing their expert opinion based on the review of the available information and their understanding drawn from publications identified from targeted literature searches. Prepared by: Ruth Bevan, Sarah Bull Reviewed by: Camilla Alexander-White, Paul Rumsby Edited by: Paul Harrison September 2020 Final Report to DWI September 2020 Contents Contents Abbreviations ............................................................................................................................. 8 Executive Summary .................................................................................................................... 9 1.0 Introduction ....................................................................................................................... 11 1.1 Project Background ............................................................................................................ 11 1.2 Personal Care Products ...................................................................................................... 11 1.3 Domestic Cleaning Products .............................................................................................