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Home , Amebucort, Betamethasone valerate, Cortisone acetate, Deflazacort, Fluorometholone, Fosdagrocorat

Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which and other bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. is an agonist, and RU486 and are antagonists of the GR. Also, and DHEA have antagonist effects on the GR.

www.MedChemExpress.com 1 Glucocorticoid Receptor Inhibitors, Agonists, Antagonists, Activators & Modulators

(20S)-Protopanaxatriol (S)- (20(S)-APPT; g-PPT) Cat. No.: HY-N0835 ((S)-ZK-245186; (S)-BOL-303242X) Cat. No.: HY-14864A

(20S)-Protopanaxatriol is a metabolite of (S)-Mapracorat is a selective and less active ginsenoside, works through the glucocorticoid glucocorticoid receptor agonist. receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.

Purity: ≥98.0% Purity: 99.40% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 5 mg, 10 mg

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione AL 082D06 Cat. No.: HY-136340 (D06; D-06) Cat. No.: HY-15709

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione AL 082D06 is a selective,

is an intermediate of delta 9,11 glucocorticoid receptor (GR) antagonist with Ki synthesis, for example, of 210 nM. (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. Purity: 99.84% Purity: 99.10% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 25 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Alclometasone (7a-​Chloro-​16a-​methyl ) Cat. No.: HY-A0150 (CL-34699) Cat. No.: HY-B1197

Alclometasone (7a-Chloro-16a-methyl prednisolone) Amcinonide inhibit NO release from activated is a glucocorticoid and inhibits the release of microglia with IC50 3.38 nM. Amcinonide has pro-inflammatory mediators from leukocytes. affinity for the glucocorticoid receptor.

Purity: >98% Purity: 99.61% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg

Amebucort AZD2906 Cat. No.: HY-U00298 Cat. No.: HY-113854

Amebucort is a synthetic glucocorticoid AZD2906 is a selective glucocorticoid receptor , may used for the research of (GR) agonist, increases micronucleated immature inflammatory disorders. erythrocytes in the bone marrow of rats. AZD2906

shows IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively. Purity: 98.04% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

AZD5423 AZD7594 Cat. No.: HY-108243 (AZ13189620) Cat. No.: HY-111453

AZD5423 is an inhaled, potent, selective, and AZD7594 is a potent selective nonsteroidal

non-steroidal glucocorticoid receptor (GR) glucocorticoid receptor modulator, with an IC50 of modulator (SGRM). AZD5423 effectively reduces 0.9 nM. allergen-induced responses in subjects with mild allergic .

Purity: 99.85% Purity: 99.60% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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AZD9567 Cat. No.: HY-120012 (Beclomethasone) Cat. No.: HY-B1540

AZD9567 (compound 15) is a potent, oral active, Beclometasone (Beclomethasone) is a prototype non-steroidal and selective glucocorticoid receptor glucocorticoid receptor agonist. modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation. Purity: ≥99.0% Purity: 95.44% Clinical Data: Phase 2 Clinical Data: Launched Size: 5 mg, 10 mg Size: 10 mM × 1 mL, 25 mg, 50 mg, 100 mg

Beclometasone dipropionate Beclomethasone 17-propionate Cat. No.: HY-13571A (Beclomethasone-17-monopropionate; 17-BMP) Cat. No.: HY-136239

Betamethasone dipropionate, the prodrug of Beclomethasone 17-propionate , is an orally active and potent (Beclomethasone-17-monopropionate), an active glucocorticoid with anti-inflammatory and metabolite of Beclomethasone dipropionate immunosuppressive activity. Betamethasone appears (HY-13571), is a glucocorticoid receptor (GR) to be an effective inhibitor of LPS-induced agonist. inflammation and MMP release. Purity: 99.92% Purity: 95.24% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 250 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg

Betamethasone Betamethasone acibutate Cat. No.: HY-13570 Cat. No.: HY-121062

Betamethasone is a synthetic glucocorticoid with Betamethasone acibutate, derives from anti-inflammatory and immunosuppressive Betamethasone, is an acetate ester. Betamethasone activities. Betamethasone accelerates fetal lung acibutate is a glucocorticoid. maturation and induces gene expression and apoptosis.

Purity: 99.97% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 1 mg, 5 mg

Betamethasone dipropionate Betamethasone hydrochloride (Betamethasone 17,21-dipropionate) Cat. No.: HY-13571 Cat. No.: HY-13570A

Betamethasone dipropionate is a glucocorticoid Betamethasone hydrochloride is a synthetic with anti-inflammatory and glucocorticoid with anti-inflammatory and immunosuppressive abilities. immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis.

Purity: 98.31% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 250 mg, 1 g Size: 1 mg, 5 mg

Betamethasone valerate BI 653048 (Betamethasone 17-valerate) Cat. No.: HY-B0727 Cat. No.: HY-12946

Betamethasone valerate (Betamethasone BI 653048 is a selective and orally active 17-valerate), the 17-valerate ester of nonsteroidal glucocorticoid (GC) agonist

Betamethasone, is a topical corticosteroid with with an IC50 value of 55 nM. BI 653048 inhibits anti-inflammatory activity. Betamethasone valerate CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 is used in the treatment of recurrent aphthous isoforms’ activity and reduces affinity for the stomatitis. hERG ion channel (IC50>30 μM). Purity: 99.14% Purity: >98% Clinical Data: Launched Clinical Data: Phase 1 Size: 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

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BI 653048 Cat. No.: HY-12946A Cat. No.: HY-13580

BI 653048 phosphate is a selective and orally Budesonide, an inhaled glucocortical steroid, is active nonsteroidal glucocorticoid an orally active glucocorticoid receptor agonist.

(GC) agonist with an IC50 value of 55 nM. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma. Purity: >98% Purity: 99.66% Clinical Data: Phase 1 Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg

Budesonide impurity C Cat. No.: HY-100087 (RPR251526) Cat. No.: HY-B0625

Budesonide impurity C is an impurity of Ciclesonide (RPR251526) is a glucocorticoid with Budesonide. Budesonide, an inhaled glucocortical an potent anti-inflammatory activity. Ciclesonide steroid, is an orally active glucocorticoid can be used for asthma research. receptor agonist.

Purity: >98% Purity: 99.45% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

Clobetasone butyrate (17-Deoxycortisol; Cat. No.: HY-B1616 11β,21-Dihydroxyprogesterone; Kendall's compound B) Cat. No.: HY-B1618

Clobetasone butyrate is a synthetic glucocorticoid Corticosterone is an adrenocortical steroid that and has topical anti-inflammatory activity has modest but significant activities as a especially in skin. Clobetasone butyrate can be and a glucocorticoid. used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis. Purity: 99.77% Purity: 99.70% Clinical Data: Launched Clinical Data: Phase 3 Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 50 mg

Cortisone (17-Hydroxy-11-dehydrocorticosterone; Kendall's acetate compound E) Cat. No.: HY-17461 (Cortisone 21-acetate) Cat. No.: HY-17461A

Cortisone (17-Hydroxy-11-dehydrocorticosterone), (Cortisone 21-acetate), an an oxidized metabolite of Cortisol (a oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. immunosuppressant and anti-inflammatory agent.

Purity: 99.90% Purity: 99.68% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

Cortodoxone Dagrocorat (11-Deoxycortisol; cortexolone; Reichstein's substance S) Cat. No.: HY-77839 (PF-00251802) Cat. No.: HY-16718

Cortodoxone is a glucocorticoid steroid hormone Dagrocorat (PF-00251802) is a novel and that can be oxygenated to cortisol dissociated glucocorticoid receptor agonist. ().

Purity: 98.74% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 100 mg Size: 1 mg, 5 mg

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Deflazacort Desisobutyryl-ciclesonide Cat. No.: HY-13609 (CIC-AP; Ciclesonide active principle) Cat. No.: HY-111490

Deflazacort, a glucocorticoid, is an inactive Desisobutyryl-ciclesonide is the active metabolite prodrug and is converted rapidly to the active of Ciclesonide. Desisobutyryl-ciclesonide has metabolite 21-desacetyldeflazacort. Deflazacort is affinity for the glucocorticoid receptor. used as an anti-inflammatory and immunosuppressant.

Purity: 99.73% Purity: 99.53% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg

Desonide Dexamethasone Cat. No.: HY-B0248 (Hexadecadrol; Prednisolone F) Cat. No.: HY-14648

Desonide is a nonfluorinated corticosteroid Dexamethasone (Hexadecadrol) is a glucocorticoid anti-inflammatory agent used topically for receptor agonist. Dexamethasone also dermatoses. Target: Glucocorticoid Receptor significantly decreases CD11b, CD18, and CD62L Desonide is a low-potency topical corticosteroid expression on neutrophils, and CD11b and CD18 that has been used for decades in the treatment of expression on monocytes. steroid-responsive dermatoses . Purity: 99.45% Purity: 99.86% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Dexamethasone acetate Dexamethasone palmitate (Dexamethasone 21-acetate; Hexadecadrol acetate) Cat. No.: HY-14648A (DXP) Cat. No.: HY-128922

Dexamethasone acetate (Dexamethasone 21-acetate) Dexamethasone palmitate (DXP) is a prodrug of is a glucocorticoid receptor agonist. Dexamethasone, which is a glucocorticoid receptor Dexamethasone acetate has the potential for agonist. Dexamethasone palmitate (DXP) has a ophthalmic infections treatment. 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Anti-inflammatory agent. Purity: 98.24% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Dexamethasone phosphate disodium (Dexamethasone 21-phosphate disodium salt) Cat. No.: HY-B1829A Cat. No.: HY-B1121

Dexamethasone phosphate disodium is a Flunisolide is a corticosteroid often used to glucocorticoid receptor agonist. treat allergic rhinitis.The principal mechanism of action of Flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.

Purity: 99.88% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 100 mg

Fluocinolone (Acetonide) Cat. No.: HY-B0415 Cat. No.: HY-B0485

Fluocinolone Acetonide is a glucocorticoid Fluocinonide (Vanos) is a potent glucocorticoid derivative used topically in the treatment of steroid used topically as anti-inflammatory agent various skin disorders. Target: Glucocorticoid for the treatment of skin disorders. Receptor is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. Purity: 99.11% Purity: 99.80% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 10 mM × 1 mL, 100 mg, 500 mg

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Fluorometholone (propionate) Cat. No.: HY-B1893 Cat. No.: HY-B0154

Fluorometholone, a synthetic glucocorticoid, is a , a potent topical glucocorticoid receptor agonist with anti-inflammatory corticosteroid, is a selective anti-inflammatory and anti-allergic properties. glucocorticoid receptor agonist, with an absolute

Fluorometholone can be used for the research of affinity (KD) of 0.5 nM. Fluticasone propionate dry eye. shows little or no activity at other steroid receptors. Anti-viral activity. Purity: 99.49% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Fluticasone furoate Cat. No.: HY-15234 (PF-04171327) Cat. No.: HY-16722

Fluticasone furoate is a topical, intranasal, Fosdagrocorat (PF-04171327) is a dissociated enhanced-affinity synthetic trifluorinated glucocorticoid receptor agonist.

corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Purity: 99.06% Purity: 99.14% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Glucocorticoid receptor agonist Glucocorticoid receptor agonist-1 Cat. No.: HY-14234 Cat. No.: HY-131974

Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist-1 is a potent

Glucocorticoid receptor agonist. IC50 value: glucocorticoid receptor agonist with an IC50 of Target:. 2.8 nM extracted from patent WO2017210471A1, compound 41.

Purity: 99.56% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 5 mg, 10 mg

GW-870086 Hydrocortisone Cat. No.: HY-103662 (Cortisol) Cat. No.: HY-N0583

GW-870086 is a potent anti-inflammatory agent, Hydrocortisone (Cortisol) is a steroid hormone or acting as a glucocorticoid receptor agonist, with glucocorticoid secreted by the adrenal cortex.

a pIC50 of 10.1 in A549 cells expressing NF-κB.

Purity: >98% Purity: 99.90% Clinical Data: Phase 2 Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Hydrocortisone acetate (Hydrocortisone 21-acetate; Cortisol 21-acetate) Cat. No.: HY-B1183 Cat. No.: HY-U00089

Hydrocortisone acetate is a corticosteroid, used Hydrocortisone cypionate is a synthetic to decrease swelling, itching, and pain that is glucocorticoid corticosteroid and a corticosteroid caused by minor skin irritations or by ester. .

Purity: 99.23% Purity: 99.97% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg, 20 mg

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Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate) Cat. No.: HY-B1402 (Hydrocortisone 21-phosphate; Cortisol 21-phosphate) Cat. No.: HY-B1155

Hydrocortisone hemisuccinate (Hydrocortisone Hydrocortisone phosphate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, 21-phosphate), a physiological glucocorticoid, and is an orally active steroidal anti-inflammatory is an orally active steroidal anti-inflammatory drug (SAID). drug (SAID).

Purity: 99.76% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Loteprednol Etabonate Etabonate D5 Cat. No.: HY-17358 Cat. No.: HY-17358S

Loteprednol etabonate (LE) is an orally active Loteprednol Etabonate D5 is a deuterium labeled "soft" steroid belonging to a unique class of Loteprednol etabonate. Loteprednol etabonate (LE) glucocorticoids. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a exhibits anti-inflammatory activity and has been unique class of glucocorticoids. Loteprednol used in optometry and ophthalmology. etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology. Purity: 99.90% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Mapracorat acetate (ZK-245186; BOL-303242X) Cat. No.: HY-14864 (Medroxyprogesterone 17-acetate; Farlutin) Cat. No.: HY-B0469

Mapracorat is a novel non-steroidal selective Medroxyprogesterone acetate is a widely used glucocorticoid receptor agonist. synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.

Purity: 99.40% Purity: 99.82% Clinical Data: Phase 3 Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

Medroxyprogesterone acetate D3 (Medroxyprogesterone 17-acetate D3; Farlutin D3) Cat. No.: HY-B0469S Cat. No.: HY-B0243

Medroxyprogesterone acetate D3 is deuterium Meprednisone is a glucocorticoid and a methylated labeled Medroxyprogesterone acetate. derivative of . Target: Glucocorticoid Medroxyprogesterone acetate is a widely used Receptor Meprednisone is a glucocorticoid and a synthetic steroid by its interaction with methylated derivative of prednisone. progesterone, androgen and glucocorticoid receptors. Purity: 98.06% Purity: 99.60% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Methylprednisolone succinate (U 7532) Cat. No.: HY-B0260 (Methylprednisolone hydrogen succinate) Cat. No.: HY-B1900

Methylprednisolone is a synthetic corticosteroid Methylprednisolone succinate is a synthetic with anti-inflammatory and immunomodulating glucocorticoid and widely used as an properties. Methylprednisolone improve severe or anti-inflammatory agent. critical COVID-19 by activating ACE2 and reducing IL-6 levels.

Purity: 99.75% Purity: 99.55% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg

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Mifepristone furoate (RU486; RU 38486) Cat. No.: HY-13683 (Sch32088) Cat. No.: HY-13693

Mifepristone (RU486) is a Mometasone furoate (Sch32088) is (PR) and glucocorticoid receptor (GR) antagonist a glucocorticoid receptor agonist with

with IC50s of 0.2 nM and 2.6 nM in in vitro assay. anti-inflammatory and anti-allergic activity.

Purity: 98.67% Purity: 99.99% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg

OP-3633 ORIC-101 Cat. No.: HY-125839 Cat. No.: HY-112710

OP-3633 is a potent and selective steroidal ORIC-101 is a highly potent and selective

glucocorticoid receptor (GR) antagonist with an glucocorticoid receptor antagonist, with an EC50

IC50 of 29 nM, with inhibition of GR of 5.6 nM. Anti-cancer activity. transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 1 mg, 5 mg Size: 5 mg, 10 mg, 25 mg

Prednisolone Prednisolone disodium phosphate Cat. No.: HY-17463 (Prednisolone 21-phosphate disodium) Cat. No.: HY-B0645

Prednisolone is a potent, orally active Prednisolone disodium phosphate is a synthetic corticosteroid and a glucocorticoid. Prednisolone glucocorticoid with anti-inflammatory and possesses about four times the anti-inflammatory immunomodulating properties. activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research. Purity: 99.92% Purity: 98.37% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 10 mM × 1 mL, 100 mg, 500 mg

Prednisolone Tebutate Prednisone Cat. No.: HY-U00098 (Dehydrocortisone) Cat. No.: HY-B0214

Prednisolone tebutate is a synthetic Prednisone (Adasone) is a synthetic corticosteroid glucocorticoid used as an antiinflammatory and agent that is particularly effective as an immunosuppressant. immunosuppressant compound. Target: Others Prednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. Purity: 99.82% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Prednisone acetate (Prednisone 21-acetate) Cat. No.: HY-B1832 Cat. No.: HY-B0328

Prednisone acetate (Prednisone 21-acetate), the Triamcinolone is a long-acting synthetic acetate salt form of prednisolone, is a corticosteroid. Triamcinolone is a corticosteroid glucocorticoid receptor agonist with hormone receptor agonist and an anti-inflammatory anti-inflammatory and immunomodulating properties. agent. Target: Glucocorticoid Receptor Dimethyl fumarate is an anti-inflammatory.

Purity: 99.61% Purity: 99.15% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

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Triamcinolone acetonide Triamcinolone Benetonide Cat. No.: HY-B0636 Cat. No.: HY-U00043

Triamcinolone acetonide is a more potent type of Triamcinolone benetonide is a synthetic triamcinolone, being about 8 times as effective as glucocorticoid corticosteroid with prednisone. anti-inflammatory activity.

Purity: 99.95% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 1 mg, 5 mg

Vamorolone ZK 216348 (VBP15) Cat. No.: HY-109017 ((+)-ZK 216348) Cat. No.: HY-123352

Vamorolone (VBP15) is a first-in-class, orally ZK 216348 ((+)-ZK 216348) is a nonsteroidal active dissociative steroidal anti-inflammatory selective glucocorticoid receptor agonist with an drug and membrane-stabilizer. Vamorolone improves IC50 of 20.3 nM. ZK 216348 also binds to without side effects. Progesterone and mineralocorticoid receptors with

Vamorolone shows potent NF-κB inhibition and IC50s of 20.4 nM and 79.9 nM, respectively. substantially reduces hormonal effects. Purity: 99.12% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 1 mg, 5 mg

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