The RACK1 Scaffold Protein: a Dynamic Cog in Cell Response Mechanisms

MOLECULAR

PHARMACOLOGY

December 2002 Volume 62 Number 6 ISSN 0026-895X

MINIREVIEW

The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms

Angela McCahill, Jim Warwicker, Graeme B. Bolger, Miles D. Houslay, and Stephen J. Yarwood 1261

ARTICLES

A^-(Piperidin-l-yl)-5-(4-chlorophenyl)-l-(2,4-dichlorophenyl)-4-methyl-lf/-pyrazole-3-carboxamide (SR141716A) Interaction with LYS 3.28(192) Is Crucial for Its Inverse Agonism at the Cannabinoid CBl Receptor

Dow P. Hurst, Diane L. Lynch, Judy Barnett-Norris, Stephen M. Hyatt, Herbert H. Seltzman,
Miao Zhong, Zhao-Hui Song, Jingjiang Nie, Deborah Lewis, and Patricia H. Reggio1274

Characterization of Two Pharmacophores on the Multidrug Transporter P-Glycoprotein

Alexia Garrigues, Nicolas Loiseau, Marcel Delaforge, Jacques Ferte, Manuel Garrigos,

Francois Andre, and Stephane Orlowski1288

Novel Roles of Liver X Receptors Exposed by Gene Expression Profiling in Liver and Adipose Tissue
Thomas M. Stulnig, Knut R. Steffensen, Hui Gao, Mark Reimers, Karin Dahlman-Wright,
Gertrud U. Schuster, and Jan-Ake Gustafsson1299

Ilj3-Hydroxyprogesterone Acts as a Mineralocorticoid Agonist in Stimulating Na1 Absorption in Mammalian Principal Cortical Collecting Duct Cells

Marie-Edith Rafestin-Oblin, Jerome Fagart, Anny Souque, Cendrine Seguin, Marcelle Bens, and
Alain Vandewalle1306

Expression Profile and Up-Regulation of Prax-1 mRNA by Antidepressant Treatment in the Rat Brain

Pascale Chardenot, Christine Roubert, Sylvaine Galiegue, Pierre Casellas, Gerard Le Fur,

Philippe Soubrie, and Florence Oury-Donat1314

Thiopurine Metabolism and Identification of the Thiopurine Metabolites Transported by MRP4 and MRP5 Overexpressed in Human Embryonic Kidney Cells

P. R. Wielinga, G. Reid, E. E, Challa, I. van der Heijden, L. van Deemter, M. de Haas, C. Mol,
A. J. Kuil, E. Groeneveld, J. D. Schuetz, C. Brouwer, R. A. De Abreu, J. Wijnholds, J. H. Beijnen,
and P. Borst__----.______.1321

Mss4 Gene Is Up-Regulated in Rat Brain after Chronic Treatment with Antidepressant and Down-Regulated When Rats Are Anhedonic

Christian Andriamampandry, Claude Muller, Catherine Schmidt-Mutter, Serge Gobaille,

Michael Spedding, Dominique Aunis, and Michel Maitre1332

i Phospholipase D Activation by Endogenous 5-Hydroxytryptamine 2C Receptors Is Mediated by Ga13

and Pertussis Toxin-Insensitive GjBy Subunits

L, McGrew, M. S. S. Chang, and E. Sanders-Bush1339

Transcriptional Regulation of the Rat Bradykinin B2 Receptor Gene: Identification of a Silencer

Element

Heloisa A. Baptista, Maria C. W. Avellar, Ronaldo C, Araujo, Jorge L, Pesquero,

Joost P. Schanstra, Jean L. Bascands, Jean P. Esteve, Antonio C. M. Paiva, Michael Bader, and

Jodo B. Pesquero1344

Inhibition of Protein Tyrosine/Mitogen-Activated Protein Kinase Phosphatase Activity Is Associated
with D2 Dopamine Receptor Supersensitivity in a Rat Model of Parkinson's Disease
Xuechu Zhen, Claudio Torres, Guoping Cai, and Eitan Friedman1356

Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome

Paul R. Graves, Jesse J. Kwiek, Patrick Fadden, Rupa Ray, Klaas Hardeman, Andrew M. Coley,

Michael Foley, and Timothy A. J. Haystead1364

A3 Adenosine Receptors in Human Astrocytoma Cells: Agonist-Mediated Desensitization, Internalization, and Down-Regulation

M. L. Trincavelli, D, Tuscano, M. Marroni, A. Falleni, V. Gremigni, S. Ceruti, M. P. Abbracchio,
K. A. Jacobson, F. Cattabeni, and C. Martini1373

Mechanism of Extracellular Signal-Regulated Kinase Activation by the CB-l Cannabinoid Receptor
Ismael Galve-Roperh, Daniel Rueda, Teresa Gomez del Pulgar, Guillermo Velasco, and
Manuel Guzman1385

Alteration of Intrinsic Biological Rhythms during Interferon Treatment and Its Possible Mechanism

Satoru Koyanagi and Shigehiro Ohdo1393

c-Myc Exerts a Protective Function through Ornithine Decarboxylase against Cellular Insults
Jong Kuk Park, Young Min Chung, Seongman Kang, Jae-Uk Kim, Yun-Taik Kim,
Hyung Jung Kim, Yeul Hong Kim, Jun Suk Kim, and Young Do Yoo1400

Enhancement of Metabolic Oxidative Stress-Induced Cytotoxicity by the Thioredoxin Inhibitor 1-
Methylpropyl 2-Imidazolyl Disulfide Is Mediated through the ASK1-SEK1-JNK1 Pathway
Yong J. Lee, Jin H. Kim, Jun Chen, and Jae J. Song1409

Characteristics of Block by Pb2+ of Function of Human Neuronal L-, N-, and R-Type Ca2+ Channels
Transiently Expressed in Human Embryonic Kidney 293 Cells
Shuangqing Peng, Ravindra K Hajela, and William D. Atchison1418

Mutation of Asn293 to Asp in Transmembrane Helix VI Abolishes Agonist-Induced but Not
Constitutive Activity of the /32-Adrenergic Receptor
Annette Hannawacker, Cornelius Krasel, and Martin J. Lohse1431

P2XXReceptor-Deficient Mice Establish the Native P2X Receptor and a P2Y6-Like Receptor in Arteries

Catherine Vial and Richard J. Evans1438

Overexpression of Protein Kinase C£ Confers Protection Against Antileukemic Drugs by Inhibiting the Redox-Dependent Sphingomyelinase Activation

Christine Bezombes, Aurelie de Thonel, Andriana Apostolou, Thierry Louat, Jean-Pierre Jaffrezou,

Guy Laurent, and Anne Quillet-Mary1446

Assembly with the Kv/31.3 Subunit Modulates Drug Block of hKvl.5 Channels

Teresa Gonzalez, Ricardo Navarro-Polanco, Cristina Arias, Ricardo Caballero, Ignacio Moreno,

Eva Delpon, Juan Tamargo, Michael M, Tamkun, and Carmen Valenzuela1456

Opioid Agonists Differentially Regulate /x-Opioid Receptors and Trafficking Proteins in Vivo

Minesh B. Patel, Chintan N. Patel, Vikram Rajashekara, and Byron C. Yoburn1464

Commitment of Activated T Cells to Secondary Responsiveness Is Enhanced by Signals Mediated by cAMP-Dependent Protein Kinase A-I

Monika Vig, Anna George, Ranjan Sen, Jeannine Durdik, Satyajit Rath, and Vineeta Bat1471

Identification of PKCa Isoform-Specific Effects in Cardiac Myocytes Using Antisense Phosphor othio ate Oligonucleotides

Risto Kerkeld, Mika lives, Sampsa Pikkarainen, Heikki Tokola, Jarkko Ronkainen,

Olli Vuolteenaho, Juhani Leppdluoto, and Heikki Ruskoaho1482

Analogs of WIN 62,577 Define a Second Allosteric Site on Muscarinic Receptors

S. Lazareno, A. Popham, and N. J. M, Birdsall1492

Reduction of G Protein-Coupled Receptor Kinase 2 Expression in U-937 Cells Attenuates H2 Histamine Receptor Desensitization and Induces Cell Maturation

Natalia Fernandez, Federico Monczor, Bibiana Lemos, Cintia Notcovich, Alberto Baldi,
Carlos Davio, and Carina Shayo1506

Mechanisms Underlying Nonsteroidal Anti-Inflammatory Drug-Induced p27if(pi Expression.

Yu-Chun Huang, Lea-Yea Chuang, and Wen-Chun Hung1515