Supplementary Table 3: Number of SINE/LINE elements in the human genome sequence flanking the 24 human-specific inversion breakpoints

Inversion Number of observed repeats Length of the regions # investigated (bp) Alu MIR LTR L1 L2 1 2 0 0 0 0 1051 3 0 0 0 0 1 1143 4 0 1 0 0 0 1263 6 0 0 0 2 0 1348 7 1 0 0 0 0 1611 10 4 0 0 0 0 2000 11 0 0 0 1 0 1649 13 0 0 0 2 0 2000 14 0 0 0 0 0 2000 15 0 0 2 0 0 1757 19 0 0 0 3 0 3000 23 1 2 4 0 0 2000 24 0 0 0 2 0 1319 25 0 1 0 1 0 1358 26 0 1 2 0 1 2000 27 0 0 0 0 1 1179 28 0 1 0 0 0 1125 29 0 0 0 0 0 1377 30 0 0 0 3 0 1411 31 0 0 0 1 0 1417 32 3 1 0 0 0 1485 33 0 0 1 0 0 1511 34 0 1 3 2 0 2000 35 0 0 1 0 0 2000 Total number of 39004 bp analysed Total number of 11 8 13 17 3 observed repeats Expected number 13.7 7 6.1 6.9 4.4 of repeatsa P-valueb 0.48 0.67 0.014 0.0011 0.56 a: The expected number of repeat elements was calculated by dividing the total number of repeat elements in the human and chimpanzee genomes by the length in bp of the respective genomes (as summarized in Supplementary Table 7) and multiplying by the length of the inversion-flanking regions analysed (in bp). b: As determined by the test for observed versus expected rates of occurrence of repeats based on the Poisson distribution. MIR: mammalian-wide interspersed repeats; LTR: Long Terminal Repeat retrotransposons